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Ready-To-Use Microwave Sensor Modified by Antibody-AuNPs Nanoconjugate for Highly Sensitive and Selective Detection of the SARS-CoV-2 Virus 抗体- aunps纳米偶联修饰的即用型微波传感器,用于高灵敏度和选择性检测SARS-CoV-2病毒
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-10-09 DOI: 10.1021/acsmeasuresciau.4c0003210.1021/acsmeasuresciau.4c00032
Jin Wang, Weijia Cui, Carolyn L. Ren and Emmanuel A. Ho*, 

The COVID-19 outbreak has led to notable developments in point-of-care (POC) diagnostic devices, as they can be valuable resources in identifying and managing the spread of the pandemic. Currently, the majority of techniques demand advanced laboratory equipment and professionals to execute precise, efficient, accurate, and sensitive testing. In this work, we report a new method to significantly enhance the sensitivity of microwave sensing of the SARS-CoV-2 virus by functionalizing the sensor surface using anti-SARS-CoV-2 spike antibody-gold nanoparticle (AuNPs) conjugates. AuNPs were surface-functionalized with the antispike antibody by EDC/NHS chemistry via PEG as a linker to form the conjugate (Ab-PEG-AuNPs). The Ab-PEG-AuNPs nanoconjugate was then coated onto the sensor through APTES and used for selectively capturing the spike protein on the SARS-CoV-2 virus. The sensing performance of the modified sensor was demonstrated via both experimental measurements and numerical simulations. Our sensor exhibited high sensitivity, achieving a limit of detection of 1,000 copies/mL of the SARS-CoV-2 virus within a 60 min time frame while requiring a minimal sample volume of 100 μL. The sensor exhibits outstanding specificity in distinguishing SARS-CoV-2 from other viruses, including influenza A and B, SARS-CoV-1, and MERS-CoV. Overall, this sensor provides a sensitive and label-free alternative for COVID-19 POC diagnosis.

2019冠状病毒病的爆发导致了即时诊断设备的显著发展,因为它们可以成为识别和管理大流行传播的宝贵资源。目前,大多数技术需要先进的实验室设备和专业人员来执行精确,高效,准确和敏感的测试。在这项工作中,我们报告了一种新的方法,通过使用抗SARS-CoV-2刺突抗体-金纳米颗粒(AuNPs)偶联物对传感器表面进行功能化,显著提高了对SARS-CoV-2病毒微波传感的灵敏度。通过EDC/NHS化学,通过PEG作为连接物,将AuNPs与抗刺突抗体表面功能化,形成偶联物(Ab-PEG-AuNPs)。然后通过APTES将Ab-PEG-AuNPs纳米偶联物涂覆在传感器上,并用于选择性捕获SARS-CoV-2病毒上的刺突蛋白。通过实验测量和数值模拟验证了改进后传感器的传感性能。我们的传感器具有很高的灵敏度,在最小样本量为100 μL的情况下,在60分钟的时间内检测到1000拷贝/mL的SARS-CoV-2病毒。该传感器在区分SARS-CoV-2与其他病毒(包括甲型和乙型流感病毒、SARS-CoV-1和中东呼吸综合征- cov)方面表现出出色的特异性。总体而言,该传感器为COVID-19 POC诊断提供了一种敏感且无标签的替代方案。
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引用次数: 0
Ready-To-Use Microwave Sensor Modified by Antibody-AuNPs Nanoconjugate for Highly Sensitive and Selective Detection of the SARS-CoV-2 Virus. 抗体- aunps纳米偶联修饰的即用型微波传感器,用于高灵敏度和选择性检测SARS-CoV-2病毒。
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-10-09 eCollection Date: 2024-12-18 DOI: 10.1021/acsmeasuresciau.4c00032
Jin Wang, Weijia Cui, Carolyn L Ren, Emmanuel A Ho

The COVID-19 outbreak has led to notable developments in point-of-care (POC) diagnostic devices, as they can be valuable resources in identifying and managing the spread of the pandemic. Currently, the majority of techniques demand advanced laboratory equipment and professionals to execute precise, efficient, accurate, and sensitive testing. In this work, we report a new method to significantly enhance the sensitivity of microwave sensing of the SARS-CoV-2 virus by functionalizing the sensor surface using anti-SARS-CoV-2 spike antibody-gold nanoparticle (AuNPs) conjugates. AuNPs were surface-functionalized with the antispike antibody by EDC/NHS chemistry via PEG as a linker to form the conjugate (Ab-PEG-AuNPs). The Ab-PEG-AuNPs nanoconjugate was then coated onto the sensor through APTES and used for selectively capturing the spike protein on the SARS-CoV-2 virus. The sensing performance of the modified sensor was demonstrated via both experimental measurements and numerical simulations. Our sensor exhibited high sensitivity, achieving a limit of detection of 1,000 copies/mL of the SARS-CoV-2 virus within a 60 min time frame while requiring a minimal sample volume of 100 μL. The sensor exhibits outstanding specificity in distinguishing SARS-CoV-2 from other viruses, including influenza A and B, SARS-CoV-1, and MERS-CoV. Overall, this sensor provides a sensitive and label-free alternative for COVID-19 POC diagnosis.

2019冠状病毒病的爆发导致了即时诊断设备的显著发展,因为它们可以成为识别和管理大流行传播的宝贵资源。目前,大多数技术需要先进的实验室设备和专业人员来执行精确,高效,准确和敏感的测试。在这项工作中,我们报告了一种新的方法,通过使用抗SARS-CoV-2刺突抗体-金纳米颗粒(AuNPs)偶联物对传感器表面进行功能化,显著提高了对SARS-CoV-2病毒微波传感的灵敏度。通过EDC/NHS化学,通过PEG作为连接物,将AuNPs与抗刺突抗体表面功能化,形成偶联物(Ab-PEG-AuNPs)。然后通过APTES将Ab-PEG-AuNPs纳米偶联物涂覆在传感器上,并用于选择性捕获SARS-CoV-2病毒上的刺突蛋白。通过实验测量和数值模拟验证了改进后传感器的传感性能。我们的传感器具有很高的灵敏度,在最小样本量为100 μL的情况下,在60分钟的时间内检测到1000拷贝/mL的SARS-CoV-2病毒。该传感器在区分SARS-CoV-2与其他病毒(包括甲型和乙型流感病毒、SARS-CoV-1和中东呼吸综合征- cov)方面表现出出色的特异性。总体而言,该传感器为COVID-19 POC诊断提供了一种敏感且无标签的替代方案。
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引用次数: 0
Enhanced Electrochemiluminescence Detection of Dopamine Using Antifouling PEDOT-Modified SPEs for Complex Biological Samples. 利用防污pedot修饰spe增强电化学发光检测复杂生物样品中的多巴胺。
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-10-04 eCollection Date: 2024-12-18 DOI: 10.1021/acsmeasuresciau.4c00053
Tzu-Yu Kao, Chia-Hung Kuo, Yu-Wei Wu, Shyh-Chyang Luo

Detecting medically important biomarkers in complex biological samples without prior treatment or extraction poses a major challenge in biomedical analysis. Electrochemical methods, specifically electrochemiluminescence (ECL), show potential due to their high sensitivity, minimal background noise, and straightforward operation. This study investigates the ECL performance of screen-printed electrodes (SPEs) modified with the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives for dopamine (DA) detection. PEDOT modification significantly enhances ECL intensity, improves sensitivity, and expands the linear range for DA detection. Functionalizing PEDOT with ethylene glycol (EG) further enhances stability, specificity, and resistance to interferences for DA detection. These modified SPEs demonstrate the linear range of 1-200 μM and a detection limit as low as 0.887 nM (S/N = 3), surpassing many previous studies using SPEs. Moreover, the PEDOT-EG4-OMe-modified SPEs can reliably detect DA in solutions with high protein concentrations or artificial cerebrospinal fluid. These results suggest that the PEDOT derivative-modified SPE can serve as reusable and sensitive DA sensors in complex biological environments, highlighting the potential of the ECL system for a range of challenging applications.

在没有事先处理或提取的情况下检测复杂生物样品中的医学重要生物标志物是生物医学分析的主要挑战。电化学方法,特别是电化学发光(ECL),由于其高灵敏度、最小的背景噪声和简单的操作,显示出潜力。本文研究了导电聚合物聚(3,4-乙烯二氧噻吩)(PEDOT)及其衍生物修饰的丝网印刷电极(spe)用于多巴胺(DA)检测的ECL性能。PEDOT修饰显著增强了ECL强度,提高了灵敏度,扩大了DA检测的线性范围。乙二醇(EG)功能化PEDOT进一步提高了DA检测的稳定性、特异性和抗干扰性。这些改进的spe线性范围为1 ~ 200 μM,检出限低至0.887 nM (S/N = 3),超过了以往许多使用spe的研究。此外,pedot - eg4 - ome修饰的spe可以可靠地检测高浓度蛋白溶液或人工脑脊液中的DA。这些结果表明,PEDOT衍生物修饰的SPE可以在复杂的生物环境中作为可重复使用的敏感DA传感器,突出了ECL系统在一系列具有挑战性的应用中的潜力。
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引用次数: 0
Simplifying Wheat Quality Assessment: Using Near-Infrared Spectroscopy and Analysis of Variance Simultaneous Component Analysis to Study Regional and Annual Effects 简化小麦品质评价:利用近红外光谱和方差分析同时成分分析研究区域和年度效应
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-10-04 DOI: 10.1021/acsmeasuresciau.4c0004410.1021/acsmeasuresciau.4c00044
Stephan Freitag*, Maximilian Anlanger, Maximilian Lippl, Klemens Mechtler, Elisabeth Reiter, Heinrich Grausgruber and Rudolf Krska, 

Assessing the quality of wheat, one of humanity’s most important crops, in a straightforward manner, is essential. In this study, analysis of variance (ANOVA) simultaneous component analysis (ASCA) paired with near-infrared spectroscopy (NIRS) was used as an easy-to-implement and environmentally friendly tool for this purpose. The capabilities of combining NIRS with ASCA were demonstrated by studying the effects of sampling site and year on the quality of 180 Austrian wheat samples across four sites over 3 years. It was found that the year, sample site, and their combination significantly (p < 0.001) affect the NIR spectra of wheat. NIR spectral preprocessing tools, usually employed in chemometric workflows, notably influence the results obtained by ASCA, particularly in terms of the variance attributed to annual and regional effects. The influence of the year was identified as the dominant factor, followed by region and the combined effect of year and sampling site. Interpretation of the loading plots obtained by ASCA demonstrates that wheat components such as proteins, carbohydrates, moisture, or fat contribute to annual and regional differences. Additionally, the protein, starch, moisture, fat, fiber, and ash contents of wheat samples obtained using a NIR-based calibration were found to be significantly influenced by year, sampling site, or their combination using ANOVA. This study shows that the combination of ASCA with NIRS simplifies NIR-based quality assessment of wheat without the need for time- and chemical-consuming calibration development.

小麦是人类最重要的作物之一,以一种直接的方式评估小麦的质量至关重要。在本研究中,方差分析(ANOVA)同时成分分析(ASCA)与近红外光谱(NIRS)相结合,作为一种易于实现且环保的工具来实现这一目的。通过研究采样地点和年份在3年内对四个地点180个奥地利小麦样品质量的影响,证明了近红外光谱与ASCA相结合的能力。结果发现,年际、样地及其组合显著(p <;0.001)影响小麦的近红外光谱。通常用于化学计量学工作流程的近红外光谱预处理工具,会显著影响ASCA获得的结果,特别是在归因于年度和区域效应的方差方面。确定年的影响是主导因素,其次是区域,年和样地的综合影响。对ASCA获得的负荷图的解释表明,小麦成分(如蛋白质、碳水化合物、水分或脂肪)导致了年度和地区差异。此外,使用基于nir的校准方法获得的小麦样品的蛋白质、淀粉、水分、脂肪、纤维和灰分含量通过方差分析发现受到年份、采样地点或它们的组合的显著影响。该研究表明,ASCA与近红外光谱的结合简化了基于nir的小麦质量评价,而不需要耗时和耗时的化学校准开发。
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引用次数: 0
Simplifying Wheat Quality Assessment: Using Near-Infrared Spectroscopy and Analysis of Variance Simultaneous Component Analysis to Study Regional and Annual Effects. 简化小麦品质评价:利用近红外光谱和方差分析同时成分分析研究区域和年度效应。
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-10-04 eCollection Date: 2024-12-18 DOI: 10.1021/acsmeasuresciau.4c00044
Stephan Freitag, Maximilian Anlanger, Maximilian Lippl, Klemens Mechtler, Elisabeth Reiter, Heinrich Grausgruber, Rudolf Krska

Assessing the quality of wheat, one of humanity's most important crops, in a straightforward manner, is essential. In this study, analysis of variance (ANOVA) simultaneous component analysis (ASCA) paired with near-infrared spectroscopy (NIRS) was used as an easy-to-implement and environmentally friendly tool for this purpose. The capabilities of combining NIRS with ASCA were demonstrated by studying the effects of sampling site and year on the quality of 180 Austrian wheat samples across four sites over 3 years. It was found that the year, sample site, and their combination significantly (p < 0.001) affect the NIR spectra of wheat. NIR spectral preprocessing tools, usually employed in chemometric workflows, notably influence the results obtained by ASCA, particularly in terms of the variance attributed to annual and regional effects. The influence of the year was identified as the dominant factor, followed by region and the combined effect of year and sampling site. Interpretation of the loading plots obtained by ASCA demonstrates that wheat components such as proteins, carbohydrates, moisture, or fat contribute to annual and regional differences. Additionally, the protein, starch, moisture, fat, fiber, and ash contents of wheat samples obtained using a NIR-based calibration were found to be significantly influenced by year, sampling site, or their combination using ANOVA. This study shows that the combination of ASCA with NIRS simplifies NIR-based quality assessment of wheat without the need for time- and chemical-consuming calibration development.

小麦是人类最重要的作物之一,以一种直接的方式评估小麦的质量至关重要。在本研究中,方差分析(ANOVA)同时成分分析(ASCA)与近红外光谱(NIRS)相结合,作为一种易于实现且环保的工具来实现这一目的。通过研究采样地点和年份在3年内对四个地点180个奥地利小麦样品质量的影响,证明了近红外光谱与ASCA相结合的能力。研究发现,年份、取样地点及其组合对小麦近红外光谱有显著影响(p < 0.001)。通常用于化学计量学工作流程的近红外光谱预处理工具,会显著影响ASCA获得的结果,特别是在归因于年度和区域效应的方差方面。确定年的影响是主导因素,其次是区域,年和样地的综合影响。对ASCA获得的负荷图的解释表明,小麦成分(如蛋白质、碳水化合物、水分或脂肪)导致了年度和地区差异。此外,使用基于nir的校准方法获得的小麦样品的蛋白质、淀粉、水分、脂肪、纤维和灰分含量通过方差分析发现受到年份、采样地点或它们的组合的显著影响。该研究表明,ASCA与近红外光谱的结合简化了基于nir的小麦质量评价,而不需要耗时和耗时的化学校准开发。
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引用次数: 0
Enhanced Electrochemiluminescence Detection of Dopamine Using Antifouling PEDOT-Modified SPEs for Complex Biological Samples 利用防污pedot修饰spe增强电化学发光检测复杂生物样品中的多巴胺
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-10-03 DOI: 10.1021/acsmeasuresciau.4c0005310.1021/acsmeasuresciau.4c00053
Tzu-Yu Kao, Chia-Hung Kuo, Yu-Wei Wu and Shyh-Chyang Luo*, 

Detecting medically important biomarkers in complex biological samples without prior treatment or extraction poses a major challenge in biomedical analysis. Electrochemical methods, specifically electrochemiluminescence (ECL), show potential due to their high sensitivity, minimal background noise, and straightforward operation. This study investigates the ECL performance of screen-printed electrodes (SPEs) modified with the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives for dopamine (DA) detection. PEDOT modification significantly enhances ECL intensity, improves sensitivity, and expands the linear range for DA detection. Functionalizing PEDOT with ethylene glycol (EG) further enhances stability, specificity, and resistance to interferences for DA detection. These modified SPEs demonstrate the linear range of 1–200 μM and a detection limit as low as 0.887 nM (S/N = 3), surpassing many previous studies using SPEs. Moreover, the PEDOT-EG4-OMe-modified SPEs can reliably detect DA in solutions with high protein concentrations or artificial cerebrospinal fluid. These results suggest that the PEDOT derivative-modified SPE can serve as reusable and sensitive DA sensors in complex biological environments, highlighting the potential of the ECL system for a range of challenging applications.

在没有事先处理或提取的情况下检测复杂生物样品中的医学重要生物标志物是生物医学分析的主要挑战。电化学方法,特别是电化学发光(ECL),由于其高灵敏度、最小的背景噪声和简单的操作,显示出潜力。本文研究了导电聚合物聚(3,4-乙烯二氧噻吩)(PEDOT)及其衍生物修饰的丝网印刷电极(spe)用于多巴胺(DA)检测的ECL性能。PEDOT修饰显著增强了ECL强度,提高了灵敏度,扩大了DA检测的线性范围。乙二醇(EG)功能化PEDOT进一步提高了DA检测的稳定性、特异性和抗干扰性。这些改进的spe线性范围为1 ~ 200 μM,检出限低至0.887 nM (S/N = 3),超过了以往许多使用spe的研究。此外,pedot - eg4 - ome修饰的spe可以可靠地检测高浓度蛋白溶液或人工脑脊液中的DA。这些结果表明,PEDOT衍生物修饰的SPE可以在复杂的生物环境中作为可重复使用的敏感DA传感器,突出了ECL系统在一系列具有挑战性的应用中的潜力。
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引用次数: 0
ATLAS-MAP: An Automated Test Station for Gated Electronic Transport Measurements ATLAS-MAP:门控电子传输测量的自动测试站
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-09-27 DOI: 10.1021/acsmeasuresciau.4c0003410.1021/acsmeasuresciau.4c00034
Amber Walton, Michael Manno, Paul J. Dauenhauer, C. Daniel Frisbie* and Daniel McDonald*, 

The diversification of electronic materials in devices provides a strong incentive for methods to rapidly correlate device performance with fabrication decisions. In this work, we present a low-cost automated test station for gated electronic transport measurements of field-effect transistors. Utilizing open-source PyMeasure libraries for transparent instrument control, the “ATLAS-MAP” system serves as a customizable interface between sourcemeters and samples under test and is programmed to conduct transfer curve and van der Pauw methods with static and sweeping gate voltages. Zinc oxide transistors of variable thickness (5, 10, and 20 nm) and channel size (50 μm to 3 mm, of equal length and width) were fabricated to validate the design. Standardization of testing procedures and raw data formatting enabled automated data analysis. A detailed list of parts and code files for the system are provided.

器件中电子材料的多样化为快速将器件性能与制造决策联系起来的方法提供了强有力的激励。在这项工作中,我们提出了一个低成本的自动化测试站,用于场效应晶体管的门控电子输运测量。利用开源PyMeasure库进行透明仪器控制,“ATLAS-MAP”系统可作为源计和被测样品之间的可定制接口,并被编程为在静态和扫频门电压下进行传递曲线和范德鲍夫方法。制作了不同厚度(5、10和20 nm)和通道尺寸(50 μm至3 mm,长度和宽度相等)的氧化锌晶体管来验证设计。标准化的测试程序和原始数据格式化实现了自动数据分析。给出了系统的详细部件清单和代码文件。
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引用次数: 0
ATLAS-MAP: An Automated Test Station for Gated Electronic Transport Measurements. ATLAS-MAP:门控电子传输测量的自动测试站。
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-09-27 eCollection Date: 2024-12-18 DOI: 10.1021/acsmeasuresciau.4c00034
Amber Walton, Michael Manno, Paul J Dauenhauer, C Daniel Frisbie, Daniel McDonald

The diversification of electronic materials in devices provides a strong incentive for methods to rapidly correlate device performance with fabrication decisions. In this work, we present a low-cost automated test station for gated electronic transport measurements of field-effect transistors. Utilizing open-source PyMeasure libraries for transparent instrument control, the "ATLAS-MAP" system serves as a customizable interface between sourcemeters and samples under test and is programmed to conduct transfer curve and van der Pauw methods with static and sweeping gate voltages. Zinc oxide transistors of variable thickness (5, 10, and 20 nm) and channel size (50 μm to 3 mm, of equal length and width) were fabricated to validate the design. Standardization of testing procedures and raw data formatting enabled automated data analysis. A detailed list of parts and code files for the system are provided.

器件中电子材料的多样化为快速将器件性能与制造决策联系起来的方法提供了强有力的激励。在这项工作中,我们提出了一个低成本的自动化测试站,用于场效应晶体管的门控电子输运测量。利用开源PyMeasure库进行透明仪器控制,“ATLAS-MAP”系统可作为源计和被测样品之间的可定制接口,并被编程为在静态和扫频门电压下进行传递曲线和范德鲍夫方法。制作了不同厚度(5、10和20 nm)和通道尺寸(50 μm至3 mm,长度和宽度相等)的氧化锌晶体管来验证设计。标准化的测试程序和原始数据格式化实现了自动数据分析。给出了系统的详细部件清单和代码文件。
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引用次数: 0
Mechanism of a Novel Carrier Buffer in Arc Atomic Emission Spectroscopy. 一种新型载流子缓冲在电弧原子发射光谱中的机理。
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-09-25 eCollection Date: 2024-12-18 DOI: 10.1021/acsmeasuresciau.4c00025
Zhi-Xiong Li, Bo-Yu Du, Lian-Kai Zhang, Jing-Jiang Yang, Shun-Rong Xue, Gui-Ren Chen, Hui Yang, Can-Feng Li, Cheng-Zhong He, Qian-Shu Lu, Song Zhang, Qiang Li

The research, which was a component of a broader initiative, focused on synthesizing a pioneering carrier buffer particularly intended for arc atomic emission spectroscopy. By analyzing various evaporation curves and quickly refining the formula of the novel carrier buffer, a more comprehensive, selective, and expedited condition was established for fractionating the target elements from the sample using the single-electrode carrier distillation method, thereby increasing the sensitivity of atomic emission spectrum analysis. Furthermore, the buffer mechanism was thoroughly investigated, using data from field emission scanning electron microscopy (SEM), X-ray powder diffraction (XRD), and energy-dispersive spectrometry (EDS). The result revealed that multiphase chemical reactions occurred within the cup-shaped electrode micrographite reactor, where the components of the carrier buffer synergistically promoted the fractionation of the measured elements. Moreover, CaCO3 and Fe2O3 had a different "catalytic" impact. Finally, it was reasonable to assume that graphite remained inert in the reaction, and the composite molten body (mSiO2·nAl2O3·xCaO·yBaO·zFe2O3) developed during the interaction between the carrier buffer and sample matrix.

这项研究是一项更广泛倡议的组成部分,重点是合成一种开创性的载流子缓冲液,特别是用于电弧原子发射光谱。通过对各种蒸发曲线的分析和对新型载流子缓冲液配方的快速细化,为单电极载流子蒸馏法从样品中分离目标元素建立了更加全面、选择性和快速的条件,从而提高了原子发射光谱分析的灵敏度。此外,利用场发射扫描电镜(SEM)、x射线粉末衍射(XRD)和能量色散光谱(EDS)等数据对缓冲机理进行了深入研究。结果表明,在杯状电极微石墨反应器内发生多相化学反应,其中载体缓冲液的组分协同促进了被测元素的分馏。此外,CaCO3和Fe2O3具有不同的“催化”作用。最后,可以合理地假设石墨在反应中保持惰性,在载体缓冲液与样品基体相互作用过程中形成复合熔融体(mSiO2·nAl2O3·xCaO·yBaO·zFe2O3)。
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引用次数: 0
Mechanism of a Novel Carrier Buffer in Arc Atomic Emission Spectroscopy 一种新型载流子缓冲在电弧原子发射光谱中的机理
IF 4.6 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2024-09-25 DOI: 10.1021/acsmeasuresciau.4c0002510.1021/acsmeasuresciau.4c00025
Zhi-xiong Li, Bo-yu Du, Lian-kai Zhang*, Jing-jiang Yang, Shun-rong Xue, Gui-ren Chen, Hui Yang, Can-feng Li, Cheng-zhong He, Qian-shu Lu, Song Zhang and Qiang Li, 

The research, which was a component of a broader initiative, focused on synthesizing a pioneering carrier buffer particularly intended for arc atomic emission spectroscopy. By analyzing various evaporation curves and quickly refining the formula of the novel carrier buffer, a more comprehensive, selective, and expedited condition was established for fractionating the target elements from the sample using the single-electrode carrier distillation method, thereby increasing the sensitivity of atomic emission spectrum analysis. Furthermore, the buffer mechanism was thoroughly investigated, using data from field emission scanning electron microscopy (SEM), X-ray powder diffraction (XRD), and energy-dispersive spectrometry (EDS). The result revealed that multiphase chemical reactions occurred within the cup-shaped electrode micrographite reactor, where the components of the carrier buffer synergistically promoted the fractionation of the measured elements. Moreover, CaCO3 and Fe2O3 had a different “catalytic” impact. Finally, it was reasonable to assume that graphite remained inert in the reaction, and the composite molten body (mSiO2·nAl2O3·xCaO·yBaO·zFe2O3) developed during the interaction between the carrier buffer and sample matrix.

这项研究是一项更广泛倡议的组成部分,重点是合成一种开创性的载流子缓冲液,特别是用于电弧原子发射光谱。通过对各种蒸发曲线的分析和对新型载流子缓冲液配方的快速细化,为单电极载流子蒸馏法从样品中分离目标元素建立了更加全面、选择性和快速的条件,从而提高了原子发射光谱分析的灵敏度。此外,利用场发射扫描电镜(SEM)、x射线粉末衍射(XRD)和能量色散光谱(EDS)等数据对缓冲机理进行了深入研究。结果表明,在杯状电极微石墨反应器内发生多相化学反应,其中载体缓冲液的组分协同促进了被测元素的分馏。此外,CaCO3和Fe2O3具有不同的“催化”作用。最后,可以合理地假设石墨在反应中保持惰性,在载体缓冲液与样品基体相互作用过程中形成复合熔融体(mSiO2·nAl2O3·xCaO·yBaO·zFe2O3)。
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ACS Measurement Science Au
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