Bioelectricity goes far beyond electrical signaling in the nervous system, but this was initially not obvious for me. This article describes the journey from studying the biophysics of ion channels in classical electrically excitable tissues to focusing on the pathogenic roles of the Kv10.1 potassium channel in cancers.
{"title":"Voltage-Gated Potassium Channels Beyond the Action Potential.","authors":"Luis A Pardo","doi":"10.1089/bioe.2022.0014","DOIUrl":"https://doi.org/10.1089/bioe.2022.0014","url":null,"abstract":"<p><p>Bioelectricity goes far beyond electrical signaling in the nervous system, but this was initially not obvious for me. This article describes the journey from studying the biophysics of ion channels in classical electrically excitable tissues to focusing on the pathogenic roles of the Kv10.1 potassium channel in cancers.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 2","pages":"117-125"},"PeriodicalIF":2.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9450483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15eCollection Date: 2022-03-01DOI: 10.1089/bioe.2022.0002
Ann M Rajnicek
{"title":"Recent Bioelectricity-Related Articles Selected by Ann M. Rajnicek, Media Editor of <i>Bioelectricity</i>.","authors":"Ann M Rajnicek","doi":"10.1089/bioe.2022.0002","DOIUrl":"https://doi.org/10.1089/bioe.2022.0002","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 1","pages":"59-64"},"PeriodicalIF":1.6,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Vaiciuleviciute, Ursule Kalvaityte, E. Bernotiene, A. Mobasheri
{"title":"Ion Channel Modulators for Treatment-Resistant Rheumatoid Arthritis: Focus on Inflammation","authors":"R. Vaiciuleviciute, Ursule Kalvaityte, E. Bernotiene, A. Mobasheri","doi":"10.1089/bioe.2021.0038","DOIUrl":"https://doi.org/10.1089/bioe.2021.0038","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"44 4 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79642513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophie Fischer-Holzhausen, K. Yamamoto, Maria P. Fjeldstad, M. Maleckar
{"title":"Probing the Putative Role of KATP Channels and Biological Variability in a Mathematical Model of Chondrocyte Electrophysiology","authors":"Sophie Fischer-Holzhausen, K. Yamamoto, Maria P. Fjeldstad, M. Maleckar","doi":"10.1089/bioe.2021.0034","DOIUrl":"https://doi.org/10.1089/bioe.2021.0034","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"99 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79644882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-02DOI: 10.1089/bioe.2021.29028.cfp
G. Sena
{"title":"Call for Special Issue Papers: Bioelectricity in Plant Morphogenesis","authors":"G. Sena","doi":"10.1089/bioe.2021.29028.cfp","DOIUrl":"https://doi.org/10.1089/bioe.2021.29028.cfp","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"5 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88811365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01Epub Date: 2021-12-16DOI: 10.1089/bioe.2021.0019
Amber Carter, Kristen Popowski, Ke Cheng, Alon Greenbaum, Frances S Ligler, Adele Moatti
Serious bone injuries have devastating effects on the lives of patients including limiting working ability and high cost. Orthopedic implants can aid in healing injuries to an extent that exceeds the natural regenerative capabilities of bone to repair fractures or large bone defects. Autografts and allografts are the standard implants used, but disadvantages such as donor site complications, a limited quantity of transplantable bone, and high costs have led to an increased demand for synthetic bone graft substitutes. However, replicating the complex physiological properties of biological bone, much less recapitulating its complex tissue functions, is challenging. Extensive efforts to design biocompatible implants that mimic the natural healing processes in bone have led to the investigation of piezoelectric smart materials because the bone has natural piezoelectric properties. Piezoelectric materials facilitate bone regeneration either by accumulating electric charge in response to mechanical stress, which mimics bioelectric signals through the direct piezoelectric effect or by providing mechanical stimulation in response to electrical stimulation through the converse piezoelectric effect. Although both effects are beneficial, the converse piezoelectric effect can address bone atrophy from stress shielding and immobility by improving the mechanical response of a healing defect. Mechanical stimulation has a positive impact on bone regeneration by activating cellular pathways that increase bone formation and decrease bone resorption. This review will highlight the potential of the converse piezoelectric effect to enhance bone regeneration by discussing the activation of beneficial cellular pathways, the properties of piezoelectric biomaterials, and the potential for the more effective administration of the converse piezoelectric effect using wireless control.
{"title":"Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation.","authors":"Amber Carter, Kristen Popowski, Ke Cheng, Alon Greenbaum, Frances S Ligler, Adele Moatti","doi":"10.1089/bioe.2021.0019","DOIUrl":"10.1089/bioe.2021.0019","url":null,"abstract":"<p><p>Serious bone injuries have devastating effects on the lives of patients including limiting working ability and high cost. Orthopedic implants can aid in healing injuries to an extent that exceeds the natural regenerative capabilities of bone to repair fractures or large bone defects. Autografts and allografts are the standard implants used, but disadvantages such as donor site complications, a limited quantity of transplantable bone, and high costs have led to an increased demand for synthetic bone graft substitutes. However, replicating the complex physiological properties of biological bone, much less recapitulating its complex tissue functions, is challenging. Extensive efforts to design biocompatible implants that mimic the natural healing processes in bone have led to the investigation of piezoelectric smart materials because the bone has natural piezoelectric properties. Piezoelectric materials facilitate bone regeneration either by accumulating electric charge in response to mechanical stress, which mimics bioelectric signals through the direct piezoelectric effect or by providing mechanical stimulation in response to electrical stimulation through the converse piezoelectric effect. Although both effects are beneficial, the converse piezoelectric effect can address bone atrophy from stress shielding and immobility by improving the mechanical response of a healing defect. Mechanical stimulation has a positive impact on bone regeneration by activating cellular pathways that increase bone formation and decrease bone resorption. This review will highlight the potential of the converse piezoelectric effect to enhance bone regeneration by discussing the activation of beneficial cellular pathways, the properties of piezoelectric biomaterials, and the potential for the more effective administration of the converse piezoelectric effect using wireless control.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"3 4","pages":"255-271"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/ae/bioe.2021.0019.PMC8742263.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9641959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1089/bioe.2021.29027.cfp2
P. Buchanan, C. Vandier
{"title":"Call for Special Issue Papers: Bioelectricity of the Tumor Microenvironment","authors":"P. Buchanan, C. Vandier","doi":"10.1089/bioe.2021.29027.cfp2","DOIUrl":"https://doi.org/10.1089/bioe.2021.29027.cfp2","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"45 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83655286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Bioelectricity of Connective Tissue Cells and Their Environments: Bridging the Gap","authors":"A. Mobasheri, M. Maleckar","doi":"10.1089/bioe.2021.0040","DOIUrl":"https://doi.org/10.1089/bioe.2021.0040","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"13 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81936499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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