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Estudo de caso de malformação congénita, com quantificação do êmbolo em 4 sistemas de suspensão para próteses endosqueléticas transtibiais com encaixe TSB 先天性畸形的案例研究,定量的柱塞在4个悬挂系统的经胫骨内窥镜假体与TSB配件
Pub Date : 2015-12-14 DOI: 10.25758/SET.1184
J. Matos, Mário Briôa, Gilda Cunha, Margarida Eiras, Margarida Ribeiro
Introduction – The piston effect is one of the main problems regarding the effectiveness of prosthesis. A decrease of the piston effect can lead to a more natural gait by increasing proprioceptivity. Objectives – Check if there is a difference in piston effect values among various suspension systems for transtibial prosthesis with the use of Liners, and test the application of imaging tests in the analysis of the better prosthetic solution for a particular individual. Methods – Radiography of the prosthesis, in charge, in the orthostatic position, keeping the weight of the amputee equally distributed on bothfeet. Then was held another x-ray in the saggittal plane with the knee flexed at 30° with a weight of 5kg applied at the distal end of the prosthesis during 30sec. After these two exams the measurements for each type of suspension system was taken. Results – Of the four studied systems only three have piston values since one of the systems did not create enough suspension to withstand the weight placed on the distal end of the prosthesis. Through the radiology exams performed, measurements of the three systems could find piston effect variations ranging from 47.91mm to 72.55mm. Conclusion – By performing the imaging study there were differences at the level of the piston effect in the various suspension systems, proving that this is a viable tool in the evaluation of the piston effect. Also through the analysis of the results was notorious that the suspension system Vacuum Assisted Suspention System (VASS) is what presents less piston effect.
导言:活塞效应是影响假体有效性的主要问题之一。减少活塞效应可以通过增加本体感觉来导致更自然的步态。目的-检查使用Liners的各种跨胫假体悬浮系统的活塞效应值是否存在差异,并测试成像测试在分析特定个体更好的假体解决方案中的应用。方法:假体的x线摄影,负责,在直立的位置,保持截肢者的重量均匀分布在双脚上。然后在矢状面再次拍x线片,膝关节屈曲30°,假体远端施加5kg的重量,持续30秒。在这两次测试之后,对每种悬挂系统进行了测量。结果:在研究的四个系统中,只有三个系统具有活塞值,因为其中一个系统没有产生足够的悬浮来承受放置在假体远端的重量。通过对三个系统的放射学检查,可以发现活塞效应的变化范围从47.91mm到72.55mm。结论-通过进行成像研究,不同悬架系统的活塞效应水平存在差异,证明这是评估活塞效应的可行工具。同时通过分析结果表明,真空辅助悬架系统是活塞效应较小的悬架系统。
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引用次数: 0
A Ressonância Magnética em Portugal 葡萄牙的磁共振成像
Pub Date : 2015-12-14 DOI: 10.25758/SET.1004
M. M. Ribeiro, Luís Freire
A utilizacao generalizada da Imagem por Ressonância Magnetica (RM) em ambiente clinico comecou a partir da 2a metade dos anos 80 e, em relacao aos metodos de imagem, nomeadamente os que utilizam Radiacao X (Rx), ofereceu uma notavel combinacao entre seguranca, devido a ausencia de radiacoes ionizantes, resolucao espacial e de contraste e uma multifacetada sensibilidade e especificidade.
广泛使用核磁共振成像(mri)在临床环境中开创了从2到80年代中期,在成像方法的关系,特别是那些使用Radiacao X (Rx),提供了一个安全之间的组合,由于缺乏radiacoes对比和太空辐射resolucao一个多方面的敏感性和特异性。
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引用次数: 0
VI Encontro Nacional das Ciências e Tecnologias da Saúde 第六届全国卫生科学与技术会议
Pub Date : 2015-12-10 DOI: 10.25758/SET.694
E. Lisboa
Este numero especial da Saude & Tecnologia e dedicado ao VI Encontro Nacional de Ciencias e Tecnologias da Saude, realizado entre 20 e 23 de Outubro de 2011, na Escola Superior de Tecnologia da Saude de Lisboa. Trata-se de um Encontro de indiscutivel valor cientifico e muito participado, a avaliar pelas cinco edicoes anteriores, realizadas desde 1993, que tem contado sempre com a presenca de cientistas prestigiados e de um numero elevado de participantes. O contexto actual que atravessa o campo da saude desafia-nos a reelaboracao das reflexoes e a redefinicao das agendas cientificas e de intervencao profissional, acompanhando as dinâmicas emergentes que envolvem este sector. E neste quadro que se insere o programa do Encontro, estruturado em torno dos cinco eixos – Investigacao, Inovacao, Praticas, Cidadania e Internacionalizacao – presentes nas comunicacoes e nos debates previstos para as diferentes conferencias, paineis, sessoes tematicas simultâneas, cursos, workshops e simposios. A revista Saude & Tecnologia nao podia, pois, deixar de se associar a este evento de referencia impar no campo das ciencias e tecnologias da saude, atraves da publicacao do programa e dos resumos das comunicacoes livres e dos posters.
本期《健康与技术》特刊专门介绍2011年10月20日至23日在里斯本Escola Superior de Tecnologia da Saude举行的第六届全国健康科学与技术会议。这是一个无可争议的科学价值和参与的会议,从1993年以来举行的前五届会议来看,一直有著名的科学家和大量的参与者出席。当前跨越卫生领域的环境要求我们根据涉及这一部门的新兴动态,重新思考和重新定义科学议程和专业干预。在这一框架下,会议计划围绕五个轴——研究、创新、实践、公民身份和国际化——在不同会议、小组讨论、同时举行的主题会议、课程、研讨会和专题讨论会的交流和辩论中呈现。因此,《Saude & Tecnologia》杂志不能不与这一卫生科学和技术领域的独特参考活动联系在一起,通过出版方案和免费交流和海报的摘要。
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引用次数: 0
Sondas moleculares para a deteção de placas β-amilóide na doença de Alzheimer 阿尔茨海默病β-淀粉样斑块检测的分子探针
Pub Date : 2015-12-07 DOI: 10.25758/SET.634
L. Quental, Goreti Ribeiro Morais, I. Santos, Antônio Paulo
The formation of amyloid structures is a neuropathological feature that characterizes several neurodegenerative disorders, such as Alzheimer´s and Parkinson´s disease. Up to now, the definitive diagnosis of these diseases can only be accomplished by immunostaining of post mortem brain tissues with dyes such Thioflavin T and congo red. Aiming at early in vivo diagnosis of Alzheimer´s disease (AD), several amyloid-avid radioprobes have been developed for b-amyloid imaging by positron emission tomography (PET) and single-photon emission computed tomography (SPECT). The aim of this paper is to present a perspective of the available amyloid imaging agents, special those that have been selected for clinical trials and are at the different stages of the US Food and Drugs Administration (FDA) approval.
淀粉样蛋白结构的形成是几种神经退行性疾病(如阿尔茨海默病和帕金森病)的神经病理学特征。到目前为止,这些疾病的明确诊断只能通过用硫黄素T和刚果红等染料对死后脑组织进行免疫染色来完成。针对阿尔茨海默病(AD)的早期体内诊断,开发了几种淀粉样蛋白放射探针,用于正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)的b-淀粉样蛋白成像。本文的目的是介绍可用的淀粉样蛋白显像剂的观点,特别是那些已被选择用于临床试验并处于美国食品和药物管理局(FDA)批准的不同阶段的显像剂。
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引用次数: 0
Estudo comparativo de procedimentos experimentais e computacionais para cálculo da lipofilia molecular 分子亲脂计算的实验和计算程序的比较研究
Pub Date : 2015-11-19 DOI: 10.25758/SET.344
G. Clemente
Comparative study of experimental and computational procedures for the calculation of molecular lipophilicity RESUMO: Introducao – A lipofilia e uma das propriedades fisico-quimicas que mais influencia a capacidade de uma molecula se movimentar atraves de compartimentos biologicos. O coeficiente de particao octanol/agua (log P ) permite, assim, obter uma estimativa da absorcao dos farmacos no organismo. A existencia de metodos indirectos para um calculo rapido do log P pode revelar-se de grande importância na analise de listas de compostos com potencial accao farmacologica, reduzindo-as aqueles que se preveem ter um melhor comportamento biologico. Objectivos – O proposito deste estudo e dar a conhecer um metodo cromatografico de RP-HPLC desenvolvido para a determinacao indirecta da lipofilia molecular e avaliar a performance de varios programas de calculo computacional desse mesmo parâmetro. Metodologias – Seleccionaram-se 25 compostos quimicos, avaliou-se o log P de cada um deles por RP-HPLC e confrontaram-se os resultados obtidos com os de sete programas computacionais. Resultados – O metodo RP-HPLC testado demonstrou ser vantajoso em comparacao com o convencional shake flask. O programa de calculo indirecto que proporcionou resultados mais proximos dos experimentais foi o ALOGPS© 2.1. Conclusoes – A escolha ideal para a determinacao da lipofilia de compostos cujo log P estimado esteja entre 0 e 6 e, sobretudo no que diz respeito a rapidez e simplicidade do processo, o metodo experimental indirecto RP-HPLC. Quanto aos metodos computacionais concluiu-se que nenhum dos programas, incluindo o ALOGPS© 2.1, demonstrou ser eficaz na avaliacao de isomeros pelo que, para estes compostos, sera sempre necessario recorrer ao metodo shake flask ou RP-HPLC. Palavras-chave: lipofilia, log P, RP-HPLC, calculo computacional
分子亲脂性计算的实验和计算程序的比较研究简介:亲脂性是影响分子通过生物室移动能力的物理化学性质之一。因此,辛醇/水分配系数(log P)可以估计药物在体内的吸收。在分析具有潜在药理作用的化合物清单时,存在快速计算log P的间接方法可能是非常重要的,减少那些预期有更好的生物学行为的化合物。目的:本研究的目的是介绍一种用于间接测定分子亲脂性的RP-HPLC色谱方法,并评估该参数的几个计算程序的性能。方法:选择25种化学化合物,用高效液相色谱法评价每一种化合物的log P,并将结果与7个计算机程序的结果进行比较。结果:与传统摇瓶相比,RP-HPLC方法具有优势。提供最接近实验结果的间接计算程序是ALOGPS©2.1。结论:对于估计对数P在0 - 6之间的化合物的亲脂性测定,特别是在过程的速度和简单性方面,间接实验方法RP-HPLC是理想的选择。计算方法得出的结论是,没有一个程序,包括ALOGPS©2.1,被证明是有效的评价异构体,因此,对于这些化合物,总是需要使用摇瓶法或RP-HPLC。关键词:亲脂性,log P, RP-HPLC,计算
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引用次数: 0
Análise da acuidade visual no implante de LIO fáquica em miopias elevadas 高近视中人工晶状体植入的视力分析
Pub Date : 2015-11-01 DOI: 10.25758/SET.1224
V. Santos, I. Poças, Carina Silva, N. Alves, A. Cardoso
Introduction – Intraocular phakic lens implantation surgery has been progressively preferred to laser surgery in the treatment of high myopia. Visual acuity (AV) pre and post refractive implant surgery has been compared, showing that this method is more effective in the improvement of the vision in high myopia. Methods – Seventy eyes belonging to 41 patients with high myopia were analyzed retrospectively. The age of the patients ranged from 20 to 50 years and they all had refractive implant surgery between 2009 and 2012. Results – One day post surgery, 42.86% of the sample had an improvement in visual acuity, 34.29% remained unchanged and 22.85% worsened. A generalized increase in the quality of vision was observed after 30 days. 64.29% scored 10/10 in visual acuity, 24.29% scored between 7/10 and 9/10, and 11.42% between 4/10 and 6/10. Conclusion – The effectiveness of this surgical technique was proved, showing an improvement in visual acuity in 52.86% of the sample
人工晶状体植入术已逐渐取代激光手术成为治疗高度近视的首选方法。对屈光植入手术前后的视敏度进行了比较,表明该方法对高度近视患者的视力改善更为有效。方法:对41例高度近视患者70只眼的资料进行回顾性分析。患者年龄在20 - 50岁之间,均在2009 - 2012年间做过屈光植入手术。结果:术后1天,42.86%的患者视力改善,34.29%的患者视力保持不变,22.85%的患者视力恶化。30天后观察到视力质量普遍提高。视力评分在10/10分的占64.29%,在7/10 ~ 9/10分的占24.29%,在4/10 ~ 6/10分的占11.42%。结论-该手术技术的有效性得到了证明,52.86%的患者的视力得到了改善
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引用次数: 0
A farmacogenética e a medicina personalizada 药物遗传学和个性化医疗
Pub Date : 2015-11-01 DOI: 10.25758/SET.1214
M. Brito
Pharmacogenetics aims to identify genetic differences between individuals that may influence the response to drug therapy, improving their effectiveness and safety. Associated with the pharmacogenetics emerges ‘personalized medicine’. In opposition to the existence of a drug that can treat all patients, the individualized treatment seems the most promising as it reduces the risk of side effects for toxicity (safety), reduces losses due to excess or deficit (dose), avoiding the testing methodology in the choice of the correct drug (effectiveness). Pharmacogenetics is relevant to the individual response to the drug in two ways: the pharmacokinetics and pharmacodynamics. The genetic variability can affect the way a drug can be absorbed, metabolized, excreted or activated, and can drive to a difference in the patient response. Among the endless number of possible examples, in this review we present examples related to cytochrome P450 genes, NAT2 gene and the Cholinesterase gene. Genetic differences between individuals can still affect the response to the drug by its pharmacodynamics, drug target-specific response to a particular drug. Among the multitude of existing drug targets, it will be presented examples of the G6PD gene, and the VKORC1 gene. Despite some evidence given for the benefit of the patient, we are still far from Pharmacogenetics to be part of routine clinical practice, perhaps because the cost-benefit have not yet been correctly assessed.
药物遗传学旨在确定个体之间可能影响药物治疗反应的遗传差异,从而提高药物治疗的有效性和安全性。与药物遗传学相关的是“个性化医疗”。相对于存在一种可以治疗所有患者的药物,个体化治疗似乎是最有希望的,因为它减少了毒性副作用的风险(安全性),减少了由于过量或不足(剂量)造成的损失,避免了选择正确药物的测试方法(有效性)。药物遗传学从两方面与个体对药物的反应有关:药代动力学和药效学。遗传变异可以影响药物的吸收、代谢、排泄或激活方式,并可能导致患者反应的差异。在无数可能的例子中,本文综述了与细胞色素P450基因、NAT2基因和胆碱酯酶基因相关的例子。个体之间的遗传差异仍然可以影响药物的药效学反应,药物对特定药物的靶特异性反应。在众多现有的药物靶点中,将介绍G6PD基因和VKORC1基因的例子。尽管有一些证据表明药物遗传学对患者有益,但我们离药物遗传学成为常规临床实践的一部分还有很长的路要走,可能是因为成本效益尚未得到正确的评估。
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引用次数: 2
Influência da experiência profissional e da função visual do operador no processamento semiautomático da cintigrafia de perfusão do miocárdio: variabilidade intra e interoperador na determinação dos parâmetros quantitativos 操作人员的专业经验和视觉功能对半自动心肌灌注闪烁图处理的影响:操作人员内和操作人员间定量参数测定的变异性
Pub Date : 2015-11-01 DOI: 10.25758/SET.1234
Ana Sofia Reimão, Joana Pereira, Matina Nobre, Fábio Nascimento, E. Carolino, I. Poças, L. Vieira
Introduction – Myocardial perfusion scan (MPS) has an important role in the diagnosis, evaluation and follow-up of patients with coronary artery disease being the semiautomatic processing widely used for routine clinical practice. Since the nuclear medicine technologists (NMT) performance might be affected by individual and environmental factors, different professionals that process the same data will provide different estimations of quantitative parameters (QP). Aim – Evaluate the influence of NMT professional experience and visual function on the MPS semiautomatic processing. Analysis of the intra and inter variability considering the function and perfusion QP measured. Methodology – Twenty subjects were selected and categorized in two groups according to their experience on the Quantitative Gated SPECTTM software: Group A (GA) – NMT ≥600h and Group B (GB) – NMT without experience. All NMT underwent an orthoptic evaluation and processed 21 MPS five times in a non-consecutive mode. It was assumed to be an altered vision when at least one visual function parameter was found abnormal. Coefficient of variation, %, was calculated to evaluate repeatability and reproducibility. Friedman’s and Wilcoxon tests were applied to compare QP between operators and to analyze GA and GB performance, respectively, considering the processing of the same MPS. To compare the NMT with normal and altered vision it was used the Mann-Whitney Test, and to evaluate the visual function influence in each QP was performed the ETA association coefficient. It was assumed statistically significant differences at a significance level of 5%. Results and Discussion – Low intra (<6.59%) and inter (<5.07%) operator variability was achieved. A greater discrepancy in GB was noted, being merely the septal wall (SW) statistical different (zw=-2.051, p=0.040), when compared with GA. Regarding the influence of visual function it was observed significant statistical differences only in left ventricle ejection fraction (LVEF) (U=11.5, p=0.012) between NMT with normal and altered vision, contributing the vision 33.99% for its variation. It was denoted more differences between NMT that have a greater incidence of ocular symptomology and a diminished Binocular Vision. LVEF was the most consistent QP (1.86%) between operators. Conclusion – MPS is presented as a repeatable and reproducible technique, operator independent. It was verified professional experience and visual function influence, on MPS semiautomatic processing, in the SW and LVEF QP, respectively
心肌灌注扫描(MPS)作为一种广泛应用于临床常规的半自动处理手段,在冠状动脉疾病的诊断、评价和随访中具有重要的作用。由于核医学技术人员(NMT)的表现可能受到个人和环境因素的影响,不同的专业人员处理相同的数据会提供不同的定量参数(QP)估计。目的:评价NMT专业经验和视觉功能对MPS半自动加工的影响。考虑功能和灌注QP的内部变异性和内部变异性分析。方法:选取20名受试者,根据其使用定量门控光谱分析软件的经验分为两组:A组(GA) - NMT≥600h, B组(GB) -无NMT经验。所有的NMT都进行了正视评估,并在非连续模式下处理了5次21 MPS。当发现至少一项视觉功能参数异常时,假定为视力改变。计算变异系数%,评价重复性和再现性。采用Friedman’s和Wilcoxon检验来比较运营商之间的QP,并分别分析GA和GB性能,考虑处理相同的MPS。为了将NMT与正常视力和改变视力进行比较,使用Mann-Whitney检验,并使用ETA关联系数来评估每个QP对视觉功能的影响。假设差异在5%的显著性水平上具有统计学意义。结果和讨论-操作者内部(<6.59%)和内部(<5.07%)可变性较低。与GA相比,GB的差异更大,仅间隔壁(SW)有统计学差异(zw=-2.051, p=0.040)。对于视觉功能的影响,只有左心室射血分数(LVEF)在视力正常和视力改变的NMT之间有显著的统计学差异(U=11.5, p=0.012),对视力的影响占33.99%。有更大的眼部症状发生率和双眼视力下降的NMT之间的差异。LVEF是操作者之间最一致的QP(1.86%)。结论:MPS是一种可重复、可重复的技术,与操作人员无关。在SW和LVEF QP中分别验证了专业经验和视觉功能对MPS半自动加工的影响
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引用次数: 1
Treino de músculos inspiratórios em indivíduos saudáveis: estudo randomizado controlado 健康受试者吸气肌肉训练:随机对照研究
Pub Date : 2015-11-01 DOI: 10.25758/SET.1331
Fábio Esteves, Inês Santos, João Valeriano, M. Tomás
Introduction – The inspiratory muscle training (IMT) emerges as an important intervention in people with COPD, but above all with a growing interest in the healthy population. However, there are not enough studies to prove if the inspiratory muscle training is also reflected in the improvement of the aerobic capacity objectified in oxygen consumption (VO 2 ). Therefore more investigation is relevant to understand the real relationship between IMT and its results on healthy people. Thus, it was considered appropriate to carry out a research study on healthy population that would allow assessing to what extent an inspiratory muscle training program induces changes in inspiratory muscular strength and aerobic capacity. Methods and analysis – The sample was based on healthy individuals ( n =19) between 18 and 21 years old who perform regular physical exercise (≥ 3 times a week or ≥ 4 hours per week). The aerobic capacity was estimated by the Ebbeling Test and inspiratory muscle strength was measured by the maximum inspiratory pressure (MIP) obtained by a specific dynamometer (MicroRPM ® ) at two different times (pre and post-workout). The above mentioned sample was randomly divided into two groups ( n =9 in the experimental group and n =10 in the control group). The experimental group (EG) was subjected to a high intensity IMT (≥50% Pi, max) while the control group (CG) didn´t go through any intervention. The IMT was performed by PowerBreathe Classic ® Level 1 and Level 2 that provides a consistent and specific pressure for inspiratory muscle strength regardless of the individual's inspiratory flow. Conclusions – After the training, there was a 37% increase in EG PIM while the CG showed an improvement of 7%. In intergroup comparison, both groups increased significantly both as MIP and VO 2 ( p <0.05). However, comparing both groups, the differences were significant for the PIM ( p =0.000), but not to VO 2 . Further studies are required to assess in which conditions IMT produces changes in aerobic capacity.
吸气肌训练(IMT)作为COPD患者的重要干预措施出现,但最重要的是对健康人群的兴趣越来越大。然而,目前还没有足够的研究来证明吸气肌训练是否也反映在以耗氧量(vo2)为客观指标的有氧能力的提高上。因此,更多的调查是有意义的,以了解IMT及其对健康人的影响之间的真正关系。因此,在健康人群中开展一项研究被认为是合适的,该研究将允许评估吸气肌训练计划在多大程度上引起吸气肌力量和有氧能力的变化。方法和分析-样本基于18至21岁定期进行体育锻炼(每周≥3次或每周≥4小时)的健康个体(n =19)。通过Ebbeling试验估计有氧能力,通过特定测力计(MicroRPM®)在两个不同时间(运动前和运动后)获得的最大吸气压力(MIP)来测量吸气肌肉力量。将上述样本随机分为两组,实验组n =9,对照组n =10。实验组(EG)给予高强度IMT(≥50% Pi, max),对照组(CG)不进行任何干预。IMT由PowerBreathe Classic®Level 1和Level 2进行,无论个人的吸气流量如何,都可以为吸气肌力量提供一致和特定的压力。结论:训练后,EG PIM增加了37%,而CG改善了7%。组间比较,两组MIP和VO 2均显著升高(p <0.05)。然而,比较两组,PIM差异显著(p =0.000),但VO 2差异不显著。需要进一步的研究来评估在哪些条件下IMT会产生有氧能力的变化。
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引用次数: 3
Novos rumos na educação e promoção da saúde a partir de uma reflexão sobre a intervenção com crianças e adolescentes no trabalho do Aventura Social 教育和健康促进的新方向来自对儿童和青少年在社会冒险工作中的干预的反思
Pub Date : 2014-11-01 DOI: 10.25758/SET.1094
M. Matos
Na ultima decada, a investigacao na area da saude deixou de se centrar apenas na compreensao das doencas e condicoes lesivas da saude para passar a interessar‑se pelos fatores determinantes destas condicoes de modo a passar a uma acao preventiva (antes de deixar que os problemas se instalem). Passou depois a interessar‑se nao so pelos problemas e seus determinantes, mas tambem pelos fatores e processos associados a promocao da propria saude, enquanto estado dinâmico de bem‑estar global.
在过去十年中,卫生领域的研究不再仅仅集中于对疾病和有害健康状况的了解,而是集中于这些状况的决定因素,以便采取预防行动(在问题出现之前)。后来,它不仅对问题及其决定因素感兴趣,而且还对促进自身健康作为全球福祉的动态状态的相关因素和过程感兴趣。
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引用次数: 1
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Saude Tecnologia
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