Abstract Background: The treatment of proximal humerus fractures is always a challenge for the Orthopedic surgeon. Proximal humeral fractures are a regular presence in clinics. In the past, the standard treatment method was conservative. The results and functional outcomes, on the other hand, were not favorable. The functional outcomes have been known to improve after the development of locking compression plates. The purpose of this study was to see how functional proximal humerus fractures were treated with locking compression plates fared. Methods: This cross-sectional interventional prospective study was carried out in the Department of Orthopedics, Prathima Institute of Medical Sciences. The study included all adult patients with closed two-part and three-part proximal humerus fractures who were reported within a week after the incident. Based on the sample size calculations and inclusion and exclusion criteria a total of n=35 patients were included in the study. Patients were followed up for 12months after surgery using a typical surgical method with a locking compression plate. Results: n=35 patients out of which n=19(54.2%) were males and n=16 (45.7%) were females. The distribution based on age involved in patients with fractures showed equal preponderance among 31-35 years and 20-25 years with n=9(25.71%).Neer's classification of fractures of proximal humerus was followed in this study. Most of the patients in n=25 (71.42%) cases were having Neer's Two-part fractures and three-part fractures were found in n=8(22.8%) and four-part in n=2(5.7%). The overall results in the study were 65.71% of patients had excellent results,20% had good results,8.5% had satisfactory results and 5.7% had poor results. Conclusion: Locking plates are a preferable therapeutic choice for proximal humerus fractures, particularly when the bone quality is poor and the fracture is comminuted. Complication rates can be reduced by using good surgical techniques and selecting the right situations. Proximal humeral internal locking plates continue to provide strong overall functionality.
{"title":"A study of Proximal Humerus Fractures treated by Locking Compression plating","authors":"Varun Krishna Komuravalli, N. Reddy","doi":"10.47799/pimr.1002.08","DOIUrl":"https://doi.org/10.47799/pimr.1002.08","url":null,"abstract":"Abstract\u0000 \u0000 Background: The treatment of proximal humerus fractures is always a challenge for the Orthopedic surgeon. Proximal humeral fractures are a regular presence in clinics. In the past, the standard treatment method was conservative. The results and functional outcomes, on the other hand, were not favorable. The functional outcomes have been known to improve after the development of locking compression plates. The purpose of this study was to see how functional proximal humerus fractures were treated with locking compression plates fared.\u0000 \u0000 Methods: This cross-sectional interventional prospective study was carried out in the Department of Orthopedics, Prathima Institute of Medical Sciences. The study included all adult patients with closed two-part and three-part proximal humerus fractures who were reported within a week after the incident. Based on the sample size calculations and inclusion and exclusion criteria a total of n=35 patients were included in the study. Patients were followed up for 12months after surgery using a typical surgical method with a locking compression plate.\u0000 \u0000 Results: n=35 patients out of which n=19(54.2%) were males and n=16 (45.7%) were females. The distribution based on age involved in patients with fractures showed equal preponderance among 31-35 years and 20-25 years with n=9(25.71%).Neer's classification of fractures of proximal humerus was followed in this study. Most of the patients in n=25 (71.42%) cases were having Neer's Two-part fractures and three-part fractures were found in n=8(22.8%) and four-part in n=2(5.7%). The overall results in the study were 65.71% of patients had excellent results,20% had good results,8.5% had satisfactory results and 5.7% had poor results. \u0000 \u0000 Conclusion: Locking plates are a preferable therapeutic choice for proximal humerus fractures, particularly when the bone quality is poor and the fracture is comminuted. Complication rates can be reduced by using good surgical techniques and selecting the right situations. Proximal humeral internal locking plates continue to provide strong overall functionality.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47647133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Tobacco use is an epidemic known as “the brown plague” affecting one billion lives in the 21st century and 80% in developing countries. Prevalence of smoking is especially high in patients with psychiatric illness with an ongoing debate over which comes first. Studies about nicotine consumption in psychiatric patients are few from developing countries. Hence, this study is designed to identify socio-demographic and diagnostic correlates of nicotine use. Aims and Objectives:- To estimate the pattern of nicotine use and determine the association between socio-demographic profile, onset of nicotine use, it’s use as a coping mechanism, psychological association with nicotine use in psychologically ill patients. Material and methods:- A cross-sectional study including 101 patients with nicotine use and psychiatric illness were administered a semi structured questionnaire, Fagerstrom Test for Nicotine Dependence(FTND) and nicotine dependence syndrome scale. Data analyzed with mean, standard deviation, chi- square, ANOVA Results:-Nicotine use was more common in middle age group with alcohol dependence followed by depression. Nicotine use was not associated with background, socioeconomic status, gender. Majority tried to quit for health but what kept them with nicotine were drive, stereotypy, continuity, priority. Conclusions:- Nicotine is a commonly abused substance in psychiatric patients without a clear demarcation about the cause effect relationship. The existing study gives few insights into reasons for nicotine intake which was more so among the productive age group. Hence, there is a need for further research about psychotropic drug interactions with nicotine use and focus on integration of nicotine cessation into treatment of other psychiatric disorders rather than separate deaddiction clinics to alleviate the illness burden.
{"title":"Pattern Of Nicotine Use And Dependence In Psychiatric Patients","authors":"R. Pattabhi, Preeti Gudlavallety, Ruthika Radham","doi":"10.47799/pimr.1002.06","DOIUrl":"https://doi.org/10.47799/pimr.1002.06","url":null,"abstract":"Abstract\u0000 \u0000 Background: Tobacco use is an epidemic known as “the brown plague” affecting one billion lives in the 21st century and 80% in developing countries. Prevalence of smoking is especially high in patients with psychiatric illness with an ongoing debate over which comes first. Studies about nicotine consumption in psychiatric patients are few from developing countries. Hence, this study is designed to identify socio-demographic and diagnostic correlates of nicotine use.\u0000 \u0000 Aims and Objectives:- To estimate the pattern of nicotine use and determine the association between socio-demographic profile, onset of nicotine use, it’s use as a coping mechanism, psychological association with nicotine use in psychologically ill patients.\u0000 \u0000 Material and methods:- A cross-sectional study including 101 patients with nicotine use and psychiatric illness were administered a semi structured questionnaire, Fagerstrom Test for Nicotine Dependence(FTND) and nicotine dependence syndrome scale. Data analyzed with mean, standard deviation, chi- square, ANOVA\u0000 \u0000 Results:-Nicotine use was more common in middle age group with alcohol dependence followed by depression. Nicotine use was not associated with background, socioeconomic status, gender. Majority tried to quit for health but what kept them with nicotine were drive, stereotypy, continuity, priority.\u0000 \u0000 Conclusions:- Nicotine is a commonly abused substance in psychiatric patients without a clear demarcation about the cause effect relationship. The existing study gives few insights into reasons for nicotine intake which was more so among the productive age group. Hence, there is a need for further research about psychotropic drug interactions with nicotine use and focus on integration of nicotine cessation into treatment of other psychiatric disorders rather than separate deaddiction clinics to alleviate the illness burden.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49001687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: The most prevalent metabolic condition, type 2 diabetes mellitus, is characterized by persistent hyperglycemia caused by abnormalities in insulin production, insulin action, or both. Iron, a transitional metal, has been demonstrated to play a key role in the pathophysiology of Type 2 Diabetes Mellitus, with a bidirectional link in which iron influences glucose metabolism, which in turn influences the iron metabolic pathways. The current study aimed to estimate the iron profile in Type 2 diabetes mellitus cases. Methods: This cross-sectional study was done in the Department of Biochemistry, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. A total of n=100 cases of type II diabetes mellitus were included in the study and age and sex-matched healthy controls were also included in the study. Laboratory investigations included Fasting Blood glucose, Serum ferritin, Total iron-binding capacity, serum iron, and serum transferrin saturation. Results: The fasting blood glucose was found to be significantly higher in the diabetes mellitus cases. The serum ferritin mean values were 105.32 µgm/dl. In the controls, the range of ferritin levels was 145 µgm/dl. The serum ferritin levels were found to be significantly reduced in the study cases as compared to the controls. Similarly, the total iron-binding capacity (TIBC) of the cases was found to be significantly increased as compared to the controls. The serum transferrin levels were also found to be elevated in the study cases as compared to the controls. Conclusion: Iron is closely related to the development of diabetes mellitus. Elevated iron and ferritin levels are risk factors for diabetes and can lead to a variety of problems. Conversely in chronic diabetics, there is a tendency to develop iron deficiency anemia and other nutritional deficiency anemias as observed by the results of the current study. As a result, iron profile evaluation can be a valuable output of the expected investigations on diabetes and related problems.
{"title":"Iron Profile in Patients with Type II Diabetes Mellitus in — A study in a Tertiary Care Hospital","authors":"Lavanya Lagisetty","doi":"10.47799/pimr.1002.09","DOIUrl":"https://doi.org/10.47799/pimr.1002.09","url":null,"abstract":"Abstract\u0000 \u0000 Background: The most prevalent metabolic condition, type 2 diabetes mellitus, is characterized by persistent hyperglycemia caused by abnormalities in insulin production, insulin action, or both. Iron, a transitional metal, has been demonstrated to play a key role in the pathophysiology of Type 2 Diabetes Mellitus, with a bidirectional link in which iron influences glucose metabolism, which in turn influences the iron metabolic pathways. The current study aimed to estimate the iron profile in Type 2 diabetes mellitus cases.\u0000 \u0000 Methods: This cross-sectional study was done in the Department of Biochemistry, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. A total of n=100 cases of type II diabetes mellitus were included in the study and age and sex-matched healthy controls were also included in the study. Laboratory investigations included Fasting Blood glucose, Serum ferritin, Total iron-binding capacity, serum iron, and serum transferrin saturation. \u0000 \u0000 Results: The fasting blood glucose was found to be significantly higher in the diabetes mellitus cases. The serum ferritin mean values were 105.32 µgm/dl. In the controls, the range of ferritin levels was 145 µgm/dl. The serum ferritin levels were found to be significantly reduced in the study cases as compared to the controls. Similarly, the total iron-binding capacity (TIBC) of the cases was found to be significantly increased as compared to the controls. The serum transferrin levels were also found to be elevated in the study cases as compared to the controls.\u0000 \u0000 Conclusion: Iron is closely related to the development of diabetes mellitus. Elevated iron and ferritin levels are risk factors for diabetes and can lead to a variety of problems. Conversely in chronic diabetics, there is a tendency to develop iron deficiency anemia and other nutritional deficiency anemias as observed by the results of the current study. As a result, iron profile evaluation can be a valuable output of the expected investigations on diabetes and related problems.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49477834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Post Stroke Depression (PSD) is one of the most frequent Neuropsychiatric consequences of stroke. It affects almost 29%-70% of Stroke Survivors (SS). There is paucity of research data in determining the risk factors and especially severity and association of depression with site of lesion location in Indian community. Aim and Objectives: To determine factors associated with PSD and association between Socio-demographic profiles, Stroke symptoms, Site of lesion with depression. Materials and Methods: It’s a cross-sectional study including participants from the outpatients section of Department of Neurology at Prathima Institute of Medical Sciences. A predetermined sample size of 60 patients with CVA patients was enrolled in the study and their socio demographic details are collected along with administering Beck’s Depression Inventory for Depression. Neuro-imaging provided information on lesion location. Collected data was analysed using SPSS version 19 and using descriptive and inferential statistics. Results: In this study 18 out of 60 subjects with stroke were diagnosed with PSD. Risk factors found to be mainly associated with PSD are lack of family support, Joint family types, Stroke with Aphasia, Cranial Nerve involvement and Motor System weakness whereas, Substance use is found to be a protective factor. Significant numbers of subjects were found to have left-anterior-sub-cortical lesions associated with PSD. Conclusion: This study highlights the variables which are to be considered in the recognition of PSD for Neurologists and Mental health care workers for early intervention and a better outcome in view of stroke recovery.
{"title":"Factors Influencing Depression In Patients Of Cerebrovascular Accidents-A Study","authors":"Jagadish Gorre, Preeti Gudlavallety, Uttam Kishan Porandla, Nagender Rao Y, Kishan Porandla","doi":"10.47799/pimr.1001.17","DOIUrl":"https://doi.org/10.47799/pimr.1001.17","url":null,"abstract":"Abstract\u0000 \u0000 Background:\u0000 Post Stroke Depression (PSD) is one of the most frequent Neuropsychiatric consequences of stroke. It affects almost 29%-70% of Stroke Survivors (SS). There is paucity of research data in determining the risk factors and especially severity and association of depression with site of lesion location in Indian community.\u0000 \u0000 Aim \u0000 and\u0000 Objectives: To determine factors associated with PSD and association between Socio-demographic profiles, Stroke symptoms, Site of lesion with depression.\u0000 \u0000 Materials and Methods: It’s a cross-sectional study including participants from the outpatients section of Department of Neurology at Prathima Institute of Medical Sciences. A predetermined sample size of 60 patients with CVA patients was enrolled in the study and their socio demographic details are collected along with administering Beck’s Depression Inventory for Depression. Neuro-imaging provided information on lesion location. Collected data was analysed using SPSS version 19 and using descriptive and inferential statistics.\u0000 \u0000 Results: In this study 18 out of 60 subjects with stroke were diagnosed with PSD. Risk factors found to be mainly associated with PSD are lack of family support, Joint family types, Stroke with Aphasia, Cranial Nerve involvement and Motor System weakness whereas, Substance use is found to be a protective factor. Significant numbers of subjects were found to have left-anterior-sub-cortical lesions associated with PSD.\u0000 \u0000 Conclusion: This study highlights the variables which are to be considered in the recognition of PSD for Neurologists and Mental health care workers for early intervention and a better outcome in view of stroke recovery.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Stroke is a neurological deficit due to acute focal injury of the central nervous system due to any vascular cause. The role of serum uric acid as a risk factor for acute stroke is an area of importance to many researchers. We in the current study tried to determine the levels of serum uric acid in cases of acute ischemic stroke and compare them with those in age and sex-matched controls. Methods: This hospital-based case-control study was performed in the Department of General Medicine, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. All the subjects were interviewed, examined, and investigated as per the predesigned and pre-tested proforma. Biochemical investigations included estimation of serum uric acid, serum triglycerides, fasting blood glucose, Renal function tests, and Liver function tests. Results: Mean Serum Uric Acid level was lower in the patients with lacunar stroke as compared to the patients with larger infarcts (6.16 ± 1.68 mg/dl vs. 6.73 ± 2.07 mg/dl). Butthisdifference was not statistically significant as the p-value is >0.05.The correlation between SUA and NIHSS score was studied with the help of Spearman rank correlation. It was found that there was a significant positive correlation between SUA and NIH stroke scale score on admission as well as at the time of discharge (p<0.05 for both). Conclusion: Elevated serum uric acid level is independently associated with acute ischemic stroke. It was observed that serum uric acid levels were correlated with hypertension, diabetes mellitus, smoking, obesity, and metabolic syndrome. It was found that cases with elevated serum acid levels had poor prognosis and overall mortality rate.
{"title":"Serum Uric Acid as an Independent Risk Factor for Acute Ischemic Stroke","authors":"Hari Shankar Akula, U. Cheeti","doi":"10.47799/pimr.1001.12","DOIUrl":"https://doi.org/10.47799/pimr.1001.12","url":null,"abstract":"Abstract\u0000 \u0000 Background: Stroke is a neurological deficit due to acute focal injury of the central nervous system due to any vascular cause. The role of serum uric acid as a risk factor for acute stroke is an area of importance to many researchers. We in the current study tried to determine the levels of serum uric acid in cases of acute ischemic stroke and compare them with those in age and sex-matched controls.\u0000 \u0000 Methods: This hospital-based case-control study was performed in the Department of General Medicine, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. All the subjects were interviewed, examined, and investigated as per the predesigned and pre-tested proforma. Biochemical investigations included estimation of serum uric acid, serum triglycerides, fasting blood glucose, Renal function tests, and Liver function tests. \u0000 \u0000 Results: Mean Serum Uric Acid level was lower in the patients with lacunar stroke as compared to the patients with larger infarcts (6.16 ± 1.68 mg/dl vs. 6.73 ± 2.07 mg/dl). Butthisdifference was not statistically significant as the p-value is >0.05.The correlation between SUA and NIHSS score was studied with the help of Spearman rank correlation. It was found that there was a significant positive correlation between SUA and NIH stroke scale score on admission as well as at the time of discharge (p<0.05 for both).\u0000 \u0000 Conclusion: Elevated serum uric acid level is independently associated with acute ischemic stroke. It was observed that serum uric acid levels were correlated with hypertension, diabetes mellitus, smoking, obesity, and metabolic syndrome. It was found that cases with elevated serum acid levels had poor prognosis and overall mortality rate.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45093871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Objective:To assess the prognostic value of Intra-abdominal Pressure in severe acute pancreatitis, compare it to APACHE II, to determine when to intervene based on intra abdominal pressure. Materials and Methods:We studied the role of intra-abdominal pressure measurement as a prognostic index and its applicability to determine the timing of intervention in cases of severe acute pancreatitis as a prospective cohort study from 2010- 2012, at Kamineni Hospital, L.B Nagar, Hyderabad. All patients who were admitted with severe acute pancreatitis and consented to take part in the study were enrolled. All patients were evaluated clinically, radiologically, biochemically and by the prognostic indices – APACHE II, Ranson criteria and intra-abdominal pressure measurement. A total of 55 patients were enrolled in this study. Intra-abdominal pressure was measured by intravesical technique using a Foley catheter.Intra-abdominal pressure was measured every 12 hours. Within 24 hours of admission, APACHE II score was obtained. Multivariate analysis was utilised for statistics. Results:Males comprised 73% of study population. Mean age was 41.23± 13.74 years (17- 83 years). Ten patients (18.81%) died. Among the non-survivors, the intra-abdominal pressure (20.1± 3.1073 Vs 8.97± 4.39) and the APACHE II (17.5 ±4.09 Vs3.93 ±4.345),were significantly greater, P value <0.0001. The AUC for intra-abdominal pressureat 24 hours and at 72 hours was >0.7, which is highly significant. The sensitivity for intra-abdominal pressure(>13 mm Hg) at 72 hours as a marker for mortality was 100%. Conclusion:The Intra-abdominal pressure monitoring is rapid, reproducible, inexpensive and minimally invasive, and can be used as a marker of the severity and prognosis of severe acute pancreatitis. Intra-abdominal pressure could potentially be used to guide the timing of intervention. Compared to APACHE II, which is inclusive of multiple parameters, intra-abdominal pressure can serve the same purpose as a single prognostic index. Further, we recommend a large, multicentric studies to conclusively establish the predictive power of intra-abdominal pressure in acute pancreatitis and whether interventions known to reduce intra-abdominal pressure, can alter the ultimate outcome.
摘要目的：评估腹腔内压对重症急性胰腺炎的预后价值，并将其与APACHE II进行比较，以确定何时根据腹腔内压进行干预。材料和方法：我们在海得拉巴纳加尔L.B Kamineni医院进行了一项前瞻性队列研究，研究了腹腔内压力测量作为预后指标的作用及其在确定重症急性胰腺炎患者干预时机方面的适用性。所有因重症急性胰腺炎入院并同意参与该研究的患者均被纳入研究。所有患者都接受了临床、放射学、生化和预后指标评估——APACHE II、Ranson标准和腹内压力测量。本研究共招募了55名患者。使用Foley导管通过膀胱内技术测量腹腔内压力。每12小时测量一次腹腔内压力。入院后24小时内，获得APACHE II评分。多变量分析用于统计。结果：男性占研究人群的73%。平均年龄41.23±13.74岁（17-83岁）。死亡10例（18.81%）。在未存活的患者中，腹内压（20.1±3.1073 Vs 8.97±4.39）和APACHE II（17.5±4.09 Vs 3.93±4.345）显著升高，P值为0.7，具有高度显著性。72小时腹腔内压（>13毫米汞柱）作为死亡率标志物的敏感性为100%。结论：腹腔压力监测具有快速、重复、廉价、微创的特点，可作为重症急性胰腺炎病情严重程度和预后的指标。腹腔内压力可能被用来指导干预的时机。与包含多个参数的APACHE II相比，腹内压可以作为单一的预后指标发挥同样的作用。此外，我们建议进行一项大型多中心研究，以最终确定腹腔内压对急性胰腺炎的预测能力，以及已知的降低腹腔内压的干预措施是否可以改变最终结果。
{"title":"Intra-abdominal Pressure as a Prognostic Factor in Severe Acute Pancreatitis","authors":"Madan Popuri, Vpl Chandrakumar Sistla","doi":"10.47799/pimr.1001.19","DOIUrl":"https://doi.org/10.47799/pimr.1001.19","url":null,"abstract":"Abstract\u0000 \u0000 Objective:To assess the prognostic value of Intra-abdominal Pressure in severe acute pancreatitis, compare it to APACHE II, to determine when to intervene based on intra abdominal pressure.\u0000 \u0000 Materials and Methods:We studied the role of intra-abdominal pressure measurement as a prognostic index and its applicability to determine the timing of intervention in cases of severe acute pancreatitis as a prospective cohort study from 2010- 2012, at Kamineni Hospital, L.B Nagar, Hyderabad. All patients who were admitted with severe acute pancreatitis and consented to take part in the study were enrolled. All patients were evaluated clinically, radiologically, biochemically and by the prognostic indices – APACHE II, Ranson criteria and intra-abdominal pressure measurement. A total of 55 patients were enrolled in this study. Intra-abdominal pressure was measured by intravesical technique using a Foley catheter.Intra-abdominal pressure was measured every 12 hours. Within 24 hours of admission, APACHE II score was obtained. Multivariate analysis was utilised for statistics.\u0000 \u0000 Results:Males comprised 73% of study population. Mean age was 41.23± 13.74 years (17- 83 years). Ten patients (18.81%) died. Among the non-survivors, the intra-abdominal pressure (20.1± 3.1073 Vs 8.97± 4.39) and the APACHE II (17.5 ±4.09 Vs3.93 ±4.345),were significantly greater, P value <0.0001. The AUC for intra-abdominal pressureat 24 hours and at 72 hours was >0.7, which is highly significant. The sensitivity for intra-abdominal pressure(>13 mm Hg) at 72 hours as a marker for mortality was 100%.\u0000 \u0000 Conclusion:The Intra-abdominal pressure monitoring is rapid, reproducible, inexpensive and minimally invasive, and can be used as a marker of the severity and prognosis of severe acute pancreatitis. Intra-abdominal pressure could potentially be used to guide the timing of intervention. Compared to APACHE II, which is inclusive of multiple parameters, intra-abdominal pressure can serve the same purpose as a single prognostic index. Further, we recommend a large, multicentric studies to conclusively establish the predictive power of intra-abdominal pressure in acute pancreatitis and whether interventions known to reduce intra-abdominal pressure, can alter the ultimate outcome.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44007275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Syed, Prenika Shangloo, B. Gupte, Sangeeta Gupta
Abstract Introduction: Aji-No-Moto (MSG), the wonder flavoring agent, has been reportedly overused in all packed food products and the cuisines being served in restaurants. This salt effect almost all the organs of the body but the evidences regarding its ill effects are very limited. Thus, no guidelines are there for the safe limits of Aji-No-Moto use. In current study we planned to analyses the histopathological effects of Aji-No-Moto on kidney. Methods: The study was conducted on 18 inbred adult albino rats of either sex. The rats of control group (C) received only standard diet with distilled water, low dose test group (T₁) rats received 0.5mg/kg of MSG dissolved in distilled water and high dose test group (T₂) rats received 1.5mg/kg of MSG dissolved in distilled water per orally for 28 days. After the experimental period, the rats were sacrificed to dissect out the renal tissue which was later subjected to histological processing and tissue sectioning. Observations: The kidney tissue sections of the control group (C) revealed normal renal architecture consisting of cortical labyrinth and medulla. The cortical labyrinth consisted of glomeruli, PCT and DCT whereas the medulla consisted of the ascending and descending limbs of loop of henle and collecting ducts. On the other hand, renal sections of low dose group (T₁) showed focal shrinkage of renal glomerulus and widening of the Bowman’s space. Furthermore, these changes were more pronounced in high dose group (T₂) along with hypercellularity of glomeruli, dilatation, hyperaemia and congestion in the intertubular cortical blood vessels and mononuclear cell infiltrate. Conclusion: Aji-No-Moto is the most widely used flavoring agent whose minimal dose for use has to be evaluated. The current study was planned to access the minimal low dose limit of MSG for use. The results of aforementioned study revealed that even small dose of 0.5mg/kg/day is capable of producing histopathological effects on kidney.
摘要简介：据报道，神奇的调味剂阿吉诺·莫托（MSG）在所有包装食品和餐馆供应的菜肴中都被过度使用。这种盐对人体几乎所有器官都有影响，但关于其不良影响的证据非常有限。因此，没有关于Aji no Moto使用的安全限制的指南。在目前的研究中，我们计划分析阿吉诺·莫托对肾脏的组织病理学影响。方法：对18只近交系成年白化病大鼠进行研究。对照组（C）只接受标准的蒸馏水饮食，低剂量试验组（T₁) 大鼠给予MSG 0.5mg/kg蒸馏水溶液和高剂量试验组（T₂) 大鼠每次口服溶于蒸馏水中的味精1.5mg/kg，持续28天。实验期结束后，处死大鼠以解剖出肾组织，随后对其进行组织学处理和组织切片。观察：对照组（C）的肾组织切片显示正常的肾脏结构，包括皮质迷路和髓质。皮质迷路由肾小球、PCT和DCT组成，而髓质由肾环的升支和降支以及集合管组成。另一方面，低剂量组（T₁) 显示肾小球局灶性缩小和鲍曼间隙变宽。此外，这些变化在高剂量组更为明显（T₂) 肾小球细胞增多，管间皮质血管扩张、充血，单核细胞浸润。结论：Aji No Moto是应用最广泛的调味剂，其最小使用剂量有待评估。目前的研究计划使用味精的最低低剂量限制。上述研究结果表明，即使是0.5mg/kg/天的小剂量也能对肾脏产生组织病理学影响。
{"title":"Effect Of AJI-NO-MOTO On Kidney Of Adult Albino Rat: A\u0000 \u0000 Histopathological Evaluation","authors":"M. Syed, Prenika Shangloo, B. Gupte, Sangeeta Gupta","doi":"10.47799/pimr.1001.04","DOIUrl":"https://doi.org/10.47799/pimr.1001.04","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Aji-No-Moto (MSG), the wonder flavoring agent, has been reportedly overused in all packed food products and the cuisines being served in restaurants. This salt effect almost all the organs of the body but the evidences regarding its ill effects are very limited. Thus, no guidelines are there for the safe limits of Aji-No-Moto use. In current study we planned to analyses the histopathological effects of Aji-No-Moto on kidney.\u0000 \u0000 Methods: The study was conducted on 18 inbred adult albino rats of either sex. The rats of control group (C) received only standard diet with distilled water, low dose test group (T₁) rats received 0.5mg/kg of MSG dissolved in distilled water and high dose test group (T₂) rats received 1.5mg/kg of MSG dissolved in distilled water per orally for 28 days. After the experimental period, the rats were sacrificed to dissect out the renal tissue which was later subjected to histological processing and tissue sectioning.\u0000 \u0000 Observations: The kidney tissue sections of the control group (C) revealed normal renal architecture consisting of cortical labyrinth and medulla. The cortical labyrinth consisted of glomeruli, PCT and DCT whereas the medulla consisted of the ascending and descending limbs of loop of henle and collecting ducts. On the other hand, renal sections of low dose group (T₁) showed focal shrinkage of renal glomerulus and widening of the Bowman’s space. Furthermore, these changes were more pronounced in high dose group (T₂) along with hypercellularity of glomeruli, dilatation, hyperaemia and congestion in the intertubular cortical blood vessels and mononuclear cell infiltrate.\u0000 \u0000 Conclusion: Aji-No-Moto is the most widely used flavoring agent whose minimal dose for use has to be evaluated. The current study was planned to access the minimal low dose limit of MSG for use. The results of aforementioned study revealed that even small dose of 0.5mg/kg/day is capable of producing histopathological effects on kidney.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44286598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction : Globally healthcare systems are jeopardized due to the COVID-19 pandemic. A fast and simple triage is very important for effective utilization of health care resources. We propose a new tool is for severity assessment of patients at the initial point of care. Objective: To propose a scoring method for fast triage of COVID 19 patients in predicting the level of care required by the patient Methods: The SCIP score is for patients who have been tested positive for COVID-19. This scoring system is useful to segregate the patients into different level of care based on values of clinical parameters like Pulse rate (PR), Respiratory rate (RR) and arterial blood oxygen saturation. The risk score ranges from 1 to 10. Lower the score more severe is the disease and hence more intense care is warranted. Result: Preliminary observation of SCIP scoring criteria is based on ten patients. On retrospective analysis it was observed that the level of care required by the patients was in correspondence with the score obtained by the SCIP formula. Conclusion: SCIP scoring system is an easy and rapid tool which may be helpful in early detection of severity and taking fast decision in the time of crisis due to COVID 19. Validation in more number of patients is required to establish the findings.
{"title":"A proposed scoring system for fast triage of COVID 19 patients using basic clinical parameters: Simple Clinical Parameter (SCIP) Score","authors":"Satish Chandel, Geeta Rai, Vandana Tayal, Niket Rai, S. Singhal, Parag Sharma","doi":"10.47799/pimr.1001.10","DOIUrl":"https://doi.org/10.47799/pimr.1001.10","url":null,"abstract":"Abstract\u0000 \u0000 Introduction\u0000 : Globally healthcare systems are jeopardized due to the COVID-19 pandemic. A fast and simple triage is very important for effective utilization of health care resources. We propose a new tool is for severity assessment of patients at the initial point of care.\u0000 \u0000 Objective: To propose a scoring method for fast triage of COVID 19 patients in predicting the level of care required by the patient \u0000 \u0000 Methods: The SCIP score is for patients who have been tested positive for COVID-19. This scoring system is useful to segregate the patients into different level of care based on values of clinical parameters like Pulse rate (PR), Respiratory rate (RR) and arterial blood oxygen saturation. The risk score ranges from 1 to 10. Lower the score more severe is the disease and hence more intense care is warranted.\u0000 Result: Preliminary observation of SCIP scoring criteria is based on ten patients. On retrospective analysis it was observed that the level of care required by the patients was in correspondence with the score obtained by the SCIP formula.\u0000 \u0000 Conclusion: SCIP scoring system is an easy and rapid tool which may be helpful in early detection of severity and taking fast decision in the time of crisis due to COVID 19. Validation in more number of patients is required to establish the findings.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46461157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Udita Singhal, Q. Mahapatra, U. Kumar, Annu Nanda, Pooja Jain, Shalini Trivedi
Abstract Introduction: Phyllodes tumours are rare fibroepithelial lesions of breast. Clinical examination, ultrasound, cytology and histopathology are the mainstay of the diagnosis. The present research was undertaken with the aim of studying the clinicopathological features of Phyllodes tumour reported in the past seven years in a Delhi government hospital. Method: A retrospective study of phyllodes tumour was carried out in females from 225 diagnosed cases of breast lesion reported in the pathology department of a government hospital in Delhi during the period of January 2013 to December2019. All the relevant history, findings of clinical examination and investigations performed were assessed from files of the patient. Results: Out of 225 cases of breast lesions reported in the pathology department 8 tumours were reported as phyllodes in the study period. The most common affected age group was 41- 50yrs. 5 (62.5 %) of 8 tumours were benign,2 (25) %) were borderline and only 1 was malignant. The tumour size was 15mm to 200mm. All the 8 cases (100%) presented with breast lump; 3 cases (30%) complained of pain in the lump. 2 cases developed ulceration and Peau D’ orange and in 1 case typical nipple retraction was seen. FNAC was done in 5 patients. No preoperative investigations were done in 2cases. Conclusion: Phyllodes tumour is a rare neoplasm of the breast. Histopathology plays an important role in differentiating it from fibroadenoma. Strict histologic assessment is definitely required for the diagnosis of the PT and for its treatment and management
{"title":"Histomorphological spectrum of Phyllodes Tumours: A Restrospective\u0000 Study","authors":"Udita Singhal, Q. Mahapatra, U. Kumar, Annu Nanda, Pooja Jain, Shalini Trivedi","doi":"10.47799/pimr.1001.07","DOIUrl":"https://doi.org/10.47799/pimr.1001.07","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Phyllodes tumours are rare fibroepithelial lesions of breast. Clinical examination, ultrasound, cytology and histopathology are the mainstay of the diagnosis. The present research was undertaken with the aim of studying the clinicopathological features of Phyllodes tumour reported in the past seven years in a Delhi government hospital. \u0000 \u0000 Method: A retrospective study of phyllodes tumour was carried out in females from 225 diagnosed cases of breast lesion reported in the pathology department of a government hospital in Delhi during the period of January 2013 to December2019. All the relevant history, findings of clinical examination and investigations performed were assessed from files of the patient.\u0000 \u0000 Results: Out of 225 cases of breast lesions reported in the pathology department 8 tumours were reported as phyllodes in the study period. The most common affected age group was 41- 50yrs. 5 (62.5 %) of 8 tumours were benign,2 (25) %) were borderline and only 1 was malignant. The tumour size was 15mm to 200mm. All the 8 cases (100%) presented with breast lump; 3 cases (30%) complained of pain in the lump. 2 cases developed ulceration and Peau D’ orange and in 1 case typical nipple retraction was seen. FNAC was done in 5 patients. No preoperative investigations were done in 2cases.\u0000 \u0000 Conclusion: Phyllodes tumour is a rare neoplasm of the breast. Histopathology plays an important role in differentiating it from fibroadenoma. Strict histologic assessment is definitely required for the diagnosis of the PT and for its treatment and management","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44937773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohan Amgothu, Venu Akkala, Sumanjali Bandi, J. T, Sudha Vatchala
Abstract Background: In India, malaria persist throughout the year and usually the incidence is more during rainy season. This necessitates the use of other laboratory methods to clinch the diagnosis, which is important in view of frequent relapses reported in vivax malaria and hence there is need for radical treatment. Considering all the above factors, a need is felt to evaluate the available lab diagnostic procedures for malaria, and also to know the trend of malaria epidemic at Warangal. Methods: It was a prospective study, conducted in the department of Microbiology, KMC Warangal. Paediatric age group with fever with chills and rigors followed by sweating were included in this research. Blood sample was collected thick and thin blood smears were prepared, stained by JSB or Leishmans or Giemsa. Parasight 'F' test and OptiMAL tests were used to detect the antigen. Chi square test was used to find the correlation between the parameters. Results: Total 300 blood samples were collected, malaria positivity was 24%, male female ratio was 1.05, statistically there was no significant difference. In area wise malaria positivity also statistically there was no significant difference. Age wise, maximum cases were diagnosed in 6 – 10 years group. Parasight F test was identified to be highly sensitive in the diagnosis of malaria among the paediatric age group. Conclusion: Falciparum malaria is identified to be the commonest malaria in this area which effect all the paediatric age groups and gender. Parasight F test was found to be the better technique in malaria diagnosis.
{"title":"Incidence of Malaria among the Pediatric Age Group Attending to MGM Hospital Warangal","authors":"Mohan Amgothu, Venu Akkala, Sumanjali Bandi, J. T, Sudha Vatchala","doi":"10.47799/pimr.1001.05","DOIUrl":"https://doi.org/10.47799/pimr.1001.05","url":null,"abstract":"Abstract\u0000 \u0000 Background: In India, malaria persist throughout the year and usually the incidence is more during rainy season. This necessitates the use of other laboratory methods to clinch the diagnosis, which is important in view of frequent relapses reported in vivax malaria and hence there is need for radical treatment. Considering all the above factors, a need is felt to evaluate the available lab diagnostic procedures for malaria, and also to know the trend of malaria epidemic at Warangal. \u0000 \u0000 Methods: It was a prospective study, conducted in the department of Microbiology, KMC Warangal. Paediatric age group with fever with chills and rigors followed by sweating were included in this research. Blood sample was collected thick and thin blood smears were prepared, stained by JSB or Leishmans or Giemsa. Parasight 'F' test and OptiMAL tests were used to detect the antigen. Chi square test was used to find the correlation between the parameters. \u0000 \u0000 Results: Total 300 blood samples were collected, malaria positivity was 24%, male female ratio was 1.05, statistically there was no significant difference. In area wise malaria positivity also statistically there was no significant difference. Age wise, maximum cases were diagnosed in 6 – 10 years group. Parasight F test was identified to be highly sensitive in the diagnosis of malaria among the paediatric age group. \u0000 \u0000 Conclusion: Falciparum malaria is identified to be the commonest malaria in this area which effect all the paediatric age groups and gender. Parasight F test was found to be the better technique in malaria diagnosis.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43854118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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