Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.046
A. Khajuria, Jyotsana Khattri, Lalit Singh, Veeresh Vg, Parmila Malik
Thrombocytopenia is the condition in which the platelets counts are less than few lakhs and cause the symptoms of the bleeding. The drugs which are used as therapeutic for the management of the diseases, due to adverse effects causes thrombocytopenia. The present study aims to find the prevalence of the drug induced thrombocytopenia in various cities in India: A cross sectional survey study design used to identify the prevalence rate of the drug induced thrombocytopenia in Lucknow 1050 samples, Panipat 1465 samples, Sonipat 815 samples, Gohana 845 samples, Delhi 1265 cities in India a total 5440 samples from 5 cities in north India were selected from different diagnostic centers.: The present study found that in Lucknow total 1050 samples were collected of them 39 samples, in Panipat total 1465 samples were collected 66 samples, in Sonipat total 815 samples were collected of them 63 samples, in Gohana total 845 samples were collected of them 40 samples and in Delhi total 1265 samples were collected of them 53 samples were drug induced thrombocytopenia respectively. The overall prevalence of drug induced thrombocytopenia is 4.7%. Drug induced thrombocytopenia is result of the adverse effect of various group of drugs used as therapeutic management and the prevalence of the drug induced thrombocytopenia is essential to manage and prevent the complication. The present study identified the prevalence of drug induced thrombocytopenia in selected North India.
{"title":"Prevalence of drug induced thrombocytopenia in five cities of India: A cross sectional descriptive study","authors":"A. Khajuria, Jyotsana Khattri, Lalit Singh, Veeresh Vg, Parmila Malik","doi":"10.18231/j.pjms.2024.046","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.046","url":null,"abstract":"Thrombocytopenia is the condition in which the platelets counts are less than few lakhs and cause the symptoms of the bleeding. The drugs which are used as therapeutic for the management of the diseases, due to adverse effects causes thrombocytopenia. The present study aims to find the prevalence of the drug induced thrombocytopenia in various cities in India: A cross sectional survey study design used to identify the prevalence rate of the drug induced thrombocytopenia in Lucknow 1050 samples, Panipat 1465 samples, Sonipat 815 samples, Gohana 845 samples, Delhi 1265 cities in India a total 5440 samples from 5 cities in north India were selected from different diagnostic centers.: The present study found that in Lucknow total 1050 samples were collected of them 39 samples, in Panipat total 1465 samples were collected 66 samples, in Sonipat total 815 samples were collected of them 63 samples, in Gohana total 845 samples were collected of them 40 samples and in Delhi total 1265 samples were collected of them 53 samples were drug induced thrombocytopenia respectively. The overall prevalence of drug induced thrombocytopenia is 4.7%. Drug induced thrombocytopenia is result of the adverse effect of various group of drugs used as therapeutic management and the prevalence of the drug induced thrombocytopenia is essential to manage and prevent the complication. The present study identified the prevalence of drug induced thrombocytopenia in selected North India.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"49 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.011
Kuppli Sai Sushma, Devi Madhavi Bhimarasetty, Siva Kumar Lotheti
In March 2016, RNTCP revised its technical and operational guidelines. One of the major additions was introduction of Daily Regimen in the treatment of Drug sensitive TB, started initially among TB-HIV co-infected patients in 2017. The present study was taken up to assess the treatment outcomes of Tuberculosis among TB-HIV co-infected patients and certain factors related to the poorer outcome of the treatment.An Observational Longitudinal study conducted at an ART centre, attached to King George Hospital in Visakhapatnam District, Andhra Pradesh, among all TB-HIV co-infected patients newly diagnosed with Drug Susceptible Tuberculosis, aged above 18years, at the selected ART centre, from the month of June 2018 to December 2018. The sample size calculated was 88 with an absolute precision of 10. Ethical clearance from Institutional Ethics Committee, Andhra Medical College; Written informed consent from all the study participants were taken prior to start of study. Confidentiality of the study participants was maintained Qualitative variables were presented as proportions. Analytical statistics include chi-square test and regression analysis. 74% of the patients had a favourable treatment outcome, 15% of the patients died and 11% of the patients were lost to follow up. Occupational status of the study participant, Socio- economic class, tobacco using habit and their CD4 counts had a statistically significant impact on their TB treatment outcome.CD4 count below 200cells/mm, Tobacco use, Diabetes Mellitus- factors responsible for unfavourable treatment outcome of Tuberculosis treatment Case-specific approaches among LFUs may be carried out to bring improvements in the strategies which are already existing or framing new strategies.
{"title":"Assessment of treatment outcome among HIV positive tuberculosis patients in Visakhapatnam","authors":"Kuppli Sai Sushma, Devi Madhavi Bhimarasetty, Siva Kumar Lotheti","doi":"10.18231/j.pjms.2024.011","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.011","url":null,"abstract":"In March 2016, RNTCP revised its technical and operational guidelines. One of the major additions was introduction of Daily Regimen in the treatment of Drug sensitive TB, started initially among TB-HIV co-infected patients in 2017. The present study was taken up to assess the treatment outcomes of Tuberculosis among TB-HIV co-infected patients and certain factors related to the poorer outcome of the treatment.An Observational Longitudinal study conducted at an ART centre, attached to King George Hospital in Visakhapatnam District, Andhra Pradesh, among all TB-HIV co-infected patients newly diagnosed with Drug Susceptible Tuberculosis, aged above 18years, at the selected ART centre, from the month of June 2018 to December 2018. The sample size calculated was 88 with an absolute precision of 10. Ethical clearance from Institutional Ethics Committee, Andhra Medical College; Written informed consent from all the study participants were taken prior to start of study. Confidentiality of the study participants was maintained Qualitative variables were presented as proportions. Analytical statistics include chi-square test and regression analysis. 74% of the patients had a favourable treatment outcome, 15% of the patients died and 11% of the patients were lost to follow up. Occupational status of the study participant, Socio- economic class, tobacco using habit and their CD4 counts had a statistically significant impact on their TB treatment outcome.CD4 count below 200cells/mm, Tobacco use, Diabetes Mellitus- factors responsible for unfavourable treatment outcome of Tuberculosis treatment Case-specific approaches among LFUs may be carried out to bring improvements in the strategies which are already existing or framing new strategies.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"18 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.028
Vipul Kumar Nagar, Nahar Singh Choudhary
Occupational injuries to eye are very common. Corneal foreign bodies (CFB) are common occupational eye injury. Studies on corneal foreign bodies due to occupational exposure are ignored in developing countries like India.Our study objective was to determine various occupations related to corneal foreign bodies and demographics, level of education and awareness of patients presenting with CFB acquired during occupational work.A hospital based cross sectional study at a tertiary hospital at Pali, Rajasthan.Patients presenting with CFB were asked about their occupation, level of education, awareness about complications of CFB and use of protective equipments at workplace.We examined total 62 patients with CFBs. All patients were male. 34% were in the age group of 18-29 yrs and 58% were in the age group of 30-45 yrs. Metal work industry was responsible for 29% of presentations and construction work industry for 26% of cases. Only 18% were using protective equipments during occupational activity. 58% patients attempted self-removal of foreign body.CFBs are common among various occupations. The sufferers are commonly young males who are poor and have low education. This occupational hazard can have blinding complications and is generally overlooked. Awareness regarding protective measures must be increased and access to eye care hospital must be increased.
{"title":"A hospital based study to evaluate etiology and epidemiology of occupational corneal foreign bodies","authors":"Vipul Kumar Nagar, Nahar Singh Choudhary","doi":"10.18231/j.pjms.2024.028","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.028","url":null,"abstract":"Occupational injuries to eye are very common. Corneal foreign bodies (CFB) are common occupational eye injury. Studies on corneal foreign bodies due to occupational exposure are ignored in developing countries like India.Our study objective was to determine various occupations related to corneal foreign bodies and demographics, level of education and awareness of patients presenting with CFB acquired during occupational work.A hospital based cross sectional study at a tertiary hospital at Pali, Rajasthan.Patients presenting with CFB were asked about their occupation, level of education, awareness about complications of CFB and use of protective equipments at workplace.We examined total 62 patients with CFBs. All patients were male. 34% were in the age group of 18-29 yrs and 58% were in the age group of 30-45 yrs. Metal work industry was responsible for 29% of presentations and construction work industry for 26% of cases. Only 18% were using protective equipments during occupational activity. 58% patients attempted self-removal of foreign body.CFBs are common among various occupations. The sufferers are commonly young males who are poor and have low education. This occupational hazard can have blinding complications and is generally overlooked. Awareness regarding protective measures must be increased and access to eye care hospital must be increased.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic kidney disease (CKD) remains a universal pandemic that has evolved into a serious public health problem that imposes a significant socioeconomic burden. Thyroid profile is disrupted in CKD patients due to aberrant thyroid hormone metabolism. The purpose of our study was to assess thyroid function in people who had chronic renal disease (CKD).According to the inclusion-exclusion criteria, this cross-sectional observational research enrolled 150 chronic renal disease patients.All patients who met the above criteria underwent a detailed history as well as a general and systemic examination. Thyroid function tests, USG entire abdomen, chest X-ray, ECG, and 2D Echocardiogram, were performed. There were 84 men and 66 women among the 150 CKD patients. Thyroid hormone abnormalities were found in 93.3 % of the individuals. 14.7 % of the participants had hypothyroidism, 14.7 % had low T3 and T4 readings, 10% had low T4 values alone, 38 % had low T3 only, and 17% had subclinical hypothyroidism. Low T3 levels (58 %) were the most prevalent thyroid anomaly, with or without low T4 or elevated TSH levels. Low T3 levels were more common in patients with advanced CKD.Thyroid hormone abnormalities are linked to different stages of chronic renal disease.
{"title":"To study thyroid profile in CKD patients in Eastern Uttar Pradesh","authors":"Anupam Srivastava, Mahim Mittal, Minakshi Awasthi, Priyanka Rai, Mahima Goel","doi":"10.18231/j.pjms.2024.050","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.050","url":null,"abstract":"Chronic kidney disease (CKD) remains a universal pandemic that has evolved into a serious public health problem that imposes a significant socioeconomic burden. Thyroid profile is disrupted in CKD patients due to aberrant thyroid hormone metabolism. The purpose of our study was to assess thyroid function in people who had chronic renal disease (CKD).According to the inclusion-exclusion criteria, this cross-sectional observational research enrolled 150 chronic renal disease patients.All patients who met the above criteria underwent a detailed history as well as a general and systemic examination. Thyroid function tests, USG entire abdomen, chest X-ray, ECG, and 2D Echocardiogram, were performed. There were 84 men and 66 women among the 150 CKD patients. Thyroid hormone abnormalities were found in 93.3 % of the individuals. 14.7 % of the participants had hypothyroidism, 14.7 % had low T3 and T4 readings, 10% had low T4 values alone, 38 % had low T3 only, and 17% had subclinical hypothyroidism. Low T3 levels (58 %) were the most prevalent thyroid anomaly, with or without low T4 or elevated TSH levels. Low T3 levels were more common in patients with advanced CKD.Thyroid hormone abnormalities are linked to different stages of chronic renal disease.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"24 93","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.007
Shreedhar Hs, Sowmyashree P, Durgappa H, Akshatha K A
Scorpion sting is an acute time limiting medical emergency commonly encountered in rural villages of the country. It is a major public health problem in many tropical and sub tropical countries. India is most affected country in Asian epidemiological data. This study was done to study the complications and outcome of scorpion sting in children. This is a prospective observational study.a total of 100 cases of scorpion sting selected from the patients admitted to Vijayanagar Institute of Medical Sciences, Ballari. The demographical features, clinical presentation, complications, outcome and the response to standard treatment protocol were observed and analysed.Scorpion sting is a common and major health problem in our area. Most commonly affected age group was 4-6 years (27%), and male children (67%) were most commonly affected. These cases were most commonly seen during March (15%) to May (14%) months. Pain at the site of sting (99%) and excessive sweating (92%) were most common presenting complaints, cold extremities (88%), tachycardia (84%), and restlessness (72%) were most common signs noted. Most common complication was myocarditis (15%), followed by pulmonary edema (7%) and encephalopathy (2%). About 98% of cases recovered without sequelae and 2% of cases died due to complications.Scorpion sting is a serious, potentially fatal emergency in our area. Cardiovascular manifestations are most common and are life threatening complication. Administration of prazosin as early as possible is the single most effective intervention to prevent complications and mortality
蝎子蜇伤是我国农村地区常见的一种急性限时医疗急症。它是许多热带和亚热带国家的主要公共卫生问题。在亚洲流行病学数据中，印度是受影响最严重的国家。本研究旨在了解儿童被蝎子蛰伤后的并发症和结果。这是一项前瞻性观察研究。研究人员从巴拉瑞（Ballari）维贾亚纳加尔医学科学研究所（Vijayanagar Institute of Medical Sciences）收治的蝎子蜇伤患者中挑选了 100 例。研究观察并分析了蝎子蛰伤的人口统计学特征、临床表现、并发症、结果以及对标准治疗方案的反应。最常受影响的年龄组为 4-6 岁（27%），男性儿童（67%）最常受影响。这些病例最常见于 3 月（15%）至 5 月（14%）。蜇伤部位疼痛（99%）和多汗（92%）是最常见的主诉，四肢冰冷（88%）、心动过速（84%）和烦躁不安（72%）是最常见的体征。最常见的并发症是心肌炎（15%），其次是肺水肿（7%）和脑病（2%）。约 98% 的病例痊愈后没有留下后遗症，2% 的病例因并发症而死亡。心血管表现是最常见的并发症，也是威胁生命的并发症。尽早使用哌唑嗪是预防并发症和死亡率的最有效干预措施。
{"title":"Scorpion sting among children with respect to its complications and outcome","authors":"Shreedhar Hs, Sowmyashree P, Durgappa H, Akshatha K A","doi":"10.18231/j.pjms.2024.007","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.007","url":null,"abstract":"Scorpion sting is an acute time limiting medical emergency commonly encountered in rural villages of the country. It is a major public health problem in many tropical and sub tropical countries. India is most affected country in Asian epidemiological data. This study was done to study the complications and outcome of scorpion sting in children. This is a prospective observational study.a total of 100 cases of scorpion sting selected from the patients admitted to Vijayanagar Institute of Medical Sciences, Ballari. The demographical features, clinical presentation, complications, outcome and the response to standard treatment protocol were observed and analysed.Scorpion sting is a common and major health problem in our area. Most commonly affected age group was 4-6 years (27%), and male children (67%) were most commonly affected. These cases were most commonly seen during March (15%) to May (14%) months. Pain at the site of sting (99%) and excessive sweating (92%) were most common presenting complaints, cold extremities (88%), tachycardia (84%), and restlessness (72%) were most common signs noted. Most common complication was myocarditis (15%), followed by pulmonary edema (7%) and encephalopathy (2%). About 98% of cases recovered without sequelae and 2% of cases died due to complications.Scorpion sting is a serious, potentially fatal emergency in our area. Cardiovascular manifestations are most common and are life threatening complication. Administration of prazosin as early as possible is the single most effective intervention to prevent complications and mortality","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"28 111","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Musculoskeletal conditions are the most common cause of long-term pain and physical disability. The burden of musculoskeletal conditions is not only in terms of global numbers but also in terms of physical and psychosocial disability. Pain arising from musculoskeletal conditions of the major joints like back, neck, shoulder, knee or multi-site involvement results in diminished quality of life. Evidence for the effectiveness and safety of the various drugs used to alleviate MSP is uncertain.The present study was an observational, cross-sectional study which included patients with complaints of musculoskeletal pain attending Regional Spine Injury Centre, S.C.B Medical College and Hospital. A total of 100 patients were included in the study. Demographic data of all the patients was collected and their level of significance in the causation of musculoskeletal pain was assessed. The prescription pattern of the drugs for musculoskeletal pain was analysed. All the patients taking the drugs were monitored for any adverse drug reaction and the same was documented.Low back ache (28%) was the most common type of musculoskeletal pain observed. Aceclofenac was the most common analgesic prescribed, followed by paracetamol and etoricoxib. Aceclofenac and paracetamol was the most common combination used. Pain abdomen was the most common ADR encountered.
{"title":"Study of utilisation pattern and adverse reaction monitoring of drugs used for relief of musculoskeletal pain in a tertiary care teaching hospital in Eastern Odisha","authors":"Sabita Palai, Rajlaxmi Upadhyay, Manasaranjan Upadhyay, Pooja Misra","doi":"10.18231/j.pjms.2024.039","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.039","url":null,"abstract":"Musculoskeletal conditions are the most common cause of long-term pain and physical disability. The burden of musculoskeletal conditions is not only in terms of global numbers but also in terms of physical and psychosocial disability. Pain arising from musculoskeletal conditions of the major joints like back, neck, shoulder, knee or multi-site involvement results in diminished quality of life. Evidence for the effectiveness and safety of the various drugs used to alleviate MSP is uncertain.The present study was an observational, cross-sectional study which included patients with complaints of musculoskeletal pain attending Regional Spine Injury Centre, S.C.B Medical College and Hospital. A total of 100 patients were included in the study. Demographic data of all the patients was collected and their level of significance in the causation of musculoskeletal pain was assessed. The prescription pattern of the drugs for musculoskeletal pain was analysed. All the patients taking the drugs were monitored for any adverse drug reaction and the same was documented.Low back ache (28%) was the most common type of musculoskeletal pain observed. Aceclofenac was the most common analgesic prescribed, followed by paracetamol and etoricoxib. Aceclofenac and paracetamol was the most common combination used. Pain abdomen was the most common ADR encountered.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"82 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.045
Anurekha G, Nallathambi M, Paranthakan C
Because India has long been a land of exotic snakes, snakebite is a serious occupational and rural hazard. Physicians pay very little attention to this occupational hazard despite the high morbidity and death. To study the various clinical profiles and the time interval between bite and start of treatment. Patients were categorized based on the envenomation centred by patient history and definitive bite evidence and graded (I-IV) grounded on a series of manifestations observed in association with the onset of treatment time that distinguishes a venomous from a non-venomous snake attack. Patients were obligating local inflammation owing to tourniquet use besides local innate therapies. Of the 100 patients deliberated, it was evident that there existed a minimal difference between the bites instigated by the snake type. Higher abnormal clotting was perceived on the arrival of patients (78%). While envenomation was predominantly reported to prompt primary coagulation abnormalities (84.32 %), neurotoxin manifestation was also found to occur at a lower rate (11.76 %). Both symptoms were also observed at a minimal level (3.92 %). Higher rates of renal failure were also reported and the clotting time normalization depended largely on patient admission time post-attack. In this investigation, the time gap between the bite and the commencement of therapy was not associated with the time required to normalize the coagulation abnormalities or develop a complication. The study also proposes appropriate protective and awareness measures that could save humankind and these reptiles together.
{"title":"A study of clinical profile of snake bite at a tertiary care centre","authors":"Anurekha G, Nallathambi M, Paranthakan C","doi":"10.18231/j.pjms.2024.045","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.045","url":null,"abstract":"Because India has long been a land of exotic snakes, snakebite is a serious occupational and rural hazard. Physicians pay very little attention to this occupational hazard despite the high morbidity and death. To study the various clinical profiles and the time interval between bite and start of treatment. Patients were categorized based on the envenomation centred by patient history and definitive bite evidence and graded (I-IV) grounded on a series of manifestations observed in association with the onset of treatment time that distinguishes a venomous from a non-venomous snake attack. Patients were obligating local inflammation owing to tourniquet use besides local innate therapies. Of the 100 patients deliberated, it was evident that there existed a minimal difference between the bites instigated by the snake type. Higher abnormal clotting was perceived on the arrival of patients (78%). While envenomation was predominantly reported to prompt primary coagulation abnormalities (84.32 %), neurotoxin manifestation was also found to occur at a lower rate (11.76 %). Both symptoms were also observed at a minimal level (3.92 %). Higher rates of renal failure were also reported and the clotting time normalization depended largely on patient admission time post-attack. In this investigation, the time gap between the bite and the commencement of therapy was not associated with the time required to normalize the coagulation abnormalities or develop a complication. The study also proposes appropriate protective and awareness measures that could save humankind and these reptiles together.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"65 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.052
M. Murmu, Subhas Chandra Majhi, Himansu Nayak, Sameer Kiro, Santosh Patil, Shitanshu Kumar Meher, Sanjukta Panda
Sickle cell disease is one of the most common hemoglobinopathies in India. A vaso-occlusive crisis is one of the most common indications for hospitalization, it accounts for 70% of hospitalization. To compare efficacy of Arginine in vaso-occlusive episode(VOE) management in terms of mean fall in pain score at discharge between intervention (Arginine) & placebo group among sickled children with skeletal vaso-occlusive crisis between 2-14 years of age. This randomized placebo control study was carried out after getting clearance from the institutional ethical & research committee, from November 2019 to October 2021 in the Indoor of Pediatrics Department, Veer Surendra Sai Institute of Medical Science (VIMSAR), Burla, Sambalpur. There is significant fall in pain score in case group as compared with control group as evidenced by p value being less than 0.001, indicating that l-arginine has significant role in reducing sickle cell vaso-occlusive episode. Mean Length of stay (LOS) in hospital in case group was 2.16, while in control group was 2.69. p value being calculated showed the value to be less than 0.001, which shows importance of l-arginine in reducing in mean length of stay in hospitalization. L-arginine plays a vital role in treating vaso-occlusive episodes. It helps to reduce the pain gradually as evidenced by noting down pain score at the time of admission & every 24 hours of therapy till discharge. It also helps to reduce the mean duration of hospitalization in vaso-occlusive episode.
{"title":"Arginine in sickle cell vaso-occlusive crisis: A randomised placebo control trial","authors":"M. Murmu, Subhas Chandra Majhi, Himansu Nayak, Sameer Kiro, Santosh Patil, Shitanshu Kumar Meher, Sanjukta Panda","doi":"10.18231/j.pjms.2024.052","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.052","url":null,"abstract":"Sickle cell disease is one of the most common hemoglobinopathies in India. A vaso-occlusive crisis is one of the most common indications for hospitalization, it accounts for 70% of hospitalization. To compare efficacy of Arginine in vaso-occlusive episode(VOE) management in terms of mean fall in pain score at discharge between intervention (Arginine) & placebo group among sickled children with skeletal vaso-occlusive crisis between 2-14 years of age. This randomized placebo control study was carried out after getting clearance from the institutional ethical & research committee, from November 2019 to October 2021 in the Indoor of Pediatrics Department, Veer Surendra Sai Institute of Medical Science (VIMSAR), Burla, Sambalpur. There is significant fall in pain score in case group as compared with control group as evidenced by p value being less than 0.001, indicating that l-arginine has significant role in reducing sickle cell vaso-occlusive episode. Mean Length of stay (LOS) in hospital in case group was 2.16, while in control group was 2.69. p value being calculated showed the value to be less than 0.001, which shows importance of l-arginine in reducing in mean length of stay in hospitalization. L-arginine plays a vital role in treating vaso-occlusive episodes. It helps to reduce the pain gradually as evidenced by noting down pain score at the time of admission & every 24 hours of therapy till discharge. It also helps to reduce the mean duration of hospitalization in vaso-occlusive episode.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"36 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.006
V. K. M, A. G V, Mohankumar C K
The effectiveness of Tofacitinib, a Janus kinase inhibitor, in patients who are hospitalised with coronavirus disease 2019 (COVID-19) pneumonia are unclear hence this study is conducted to evaluate the efficacy of Tofacitinib on treatment outcome in patients hospitalised with COVID-19 pneumonia.All diagnosed cases of SARS COV2 who required O2 therapy at the start of the study will be undergoing routine investigations according to COVID 19 management guidelines and will be treated with adequate immunosuppression with corticosteroids. Those patients whose inflammatory markers (CRP, S LDH, D DIMER) are not decreasing after 48 hours of corticosteroids therapy may be given Tab Tofacitinib 10mg bid for a period of 14 days or till the decrease in inflammatory markers, whichever is earlier. Oxygen requirement and inflammatory markers were assessed every 3 day. Out of 27 patients who didn’t respond for corticosteroids 20 were given the drug tab tofacitinb 10mg BD. CRP in the both the steroid non responders and steroid responders groups was high till day 9, on day 14 the CRP levels were normal in 50% of steroid non responders. S LDH levels in the steroid non responders group was in the decreasing trend i.e., on day 14 it was normal in 70% of patients.. The levels of D DIMER in tofacitinib group was high till day 6, and on day 14 the D-DIMER levels were normal in 40% patients. Oxygen requirement showed drastic changes in the steroid non responders group. Among patients hospitalized with COVID-19 pneumonia, addition of Tofacitinib to steroid non responders group showed early improvement in their clinical and biochemical levels. Hence, Tab tofacitinib can be recommended an adjunct to steroids for early clinical and biochemical improvement for treatment of moderate to severe cases of COVID-19.
{"title":"To determine the effectiveness of Tofacitinib on treatment outcome in patients hospitalised with COVID-19 pneumonia- A longitudinal observational study in a tertiary care Hospital Mandya","authors":"V. K. M, A. G V, Mohankumar C K","doi":"10.18231/j.pjms.2024.006","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.006","url":null,"abstract":"The effectiveness of Tofacitinib, a Janus kinase inhibitor, in patients who are hospitalised with coronavirus disease 2019 (COVID-19) pneumonia are unclear hence this study is conducted to evaluate the efficacy of Tofacitinib on treatment outcome in patients hospitalised with COVID-19 pneumonia.All diagnosed cases of SARS COV2 who required O2 therapy at the start of the study will be undergoing routine investigations according to COVID 19 management guidelines and will be treated with adequate immunosuppression with corticosteroids. Those patients whose inflammatory markers (CRP, S LDH, D DIMER) are not decreasing after 48 hours of corticosteroids therapy may be given Tab Tofacitinib 10mg bid for a period of 14 days or till the decrease in inflammatory markers, whichever is earlier. Oxygen requirement and inflammatory markers were assessed every 3 day. Out of 27 patients who didn’t respond for corticosteroids 20 were given the drug tab tofacitinb 10mg BD. CRP in the both the steroid non responders and steroid responders groups was high till day 9, on day 14 the CRP levels were normal in 50% of steroid non responders. S LDH levels in the steroid non responders group was in the decreasing trend i.e., on day 14 it was normal in 70% of patients.. The levels of D DIMER in tofacitinib group was high till day 6, and on day 14 the D-DIMER levels were normal in 40% patients. Oxygen requirement showed drastic changes in the steroid non responders group. Among patients hospitalized with COVID-19 pneumonia, addition of Tofacitinib to steroid non responders group showed early improvement in their clinical and biochemical levels. Hence, Tab tofacitinib can be recommended an adjunct to steroids for early clinical and biochemical improvement for treatment of moderate to severe cases of COVID-19.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"73 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
According to epidemiological studies, the 30% of aged 75 years and older is having impaired vision and most of the cases these patients are not in contact of the hospital care staff and community eye services. The visual assessment of older people is essential and helps to minimize the issues related to fall that led to critical problem. The proper vision is required for regain independence and improve the patient’s overall wellbeing. This kind of situation is leading the individual to unintentional injury which is higher among the visually impaired people compared to fully sighted population. Moreover, there are two major reasons for visual impairment that are more susceptible.The study aims to analyze the prevalence of visual impairment in patients sustaining proximal hip fracture after a simple fall at SCB Medical College and Hospital, Cuttack, Odisha.The current study has been conducted at SCB Medical College and Hospital, Cuttack, Odisha. All inpatients of the orthopaedic rehabilitation wards were recuperating from the surgical repair of a fractured neck of femur aged 75 years and above. and all the visual impairment assessed at Ophthalmology OPD. Moreover, the investigator has also invited the patients who sustained their fracture after a simple slip, trip and fall. Apart from this, the mental test of these participants was also done to analyze the ability. In this test the score of seven and above was considered for allowing the patients to take part in the study. There was a full ocular examination of anterior and posterior segment performed by the ophthalmologist using the slit-lamp bio microscope and indirect ophthalmoscope.Visual impairment of criteria 1 sensitivity was 93% and specificity was 91%. Moreover, the likelihood ratio of positive results was 11 and negative result was 0.05. For the criteria 2 the sensitivity was 97% and specificity was 86%. Moreover, the likelihood of positive results was 6 and negative result was 0.02. Apart from this detection of potentially remedial visual impairment sensitivity was 69% and specificity was 91%. The likelihood ratio of positive result was 8 and negative result was 0.2.The vision test and proper ocular examination were underestimated the extent of vision impairment in older adults. As per the outcome of the study, the visual impairment is common in elderly patients with a history of falls. Moreover, the study has suggested that to measure the visual acuity of all elderly patients recuperating from a proximal hip fracture after a simple fall.
{"title":"Prevalence of visual impairment in patients sustaining proximal hip fracture after a simple fall","authors":"Sambit Kumar Panda, Laxmidhar Jena, Jitendra Kumar Panda, Sandhyarani Nath, Gopabandhu Patra","doi":"10.18231/j.pjms.2024.008","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.008","url":null,"abstract":"According to epidemiological studies, the 30% of aged 75 years and older is having impaired vision and most of the cases these patients are not in contact of the hospital care staff and community eye services. The visual assessment of older people is essential and helps to minimize the issues related to fall that led to critical problem. The proper vision is required for regain independence and improve the patient’s overall wellbeing. This kind of situation is leading the individual to unintentional injury which is higher among the visually impaired people compared to fully sighted population. Moreover, there are two major reasons for visual impairment that are more susceptible.The study aims to analyze the prevalence of visual impairment in patients sustaining proximal hip fracture after a simple fall at SCB Medical College and Hospital, Cuttack, Odisha.The current study has been conducted at SCB Medical College and Hospital, Cuttack, Odisha. All inpatients of the orthopaedic rehabilitation wards were recuperating from the surgical repair of a fractured neck of femur aged 75 years and above. and all the visual impairment assessed at Ophthalmology OPD. Moreover, the investigator has also invited the patients who sustained their fracture after a simple slip, trip and fall. Apart from this, the mental test of these participants was also done to analyze the ability. In this test the score of seven and above was considered for allowing the patients to take part in the study. There was a full ocular examination of anterior and posterior segment performed by the ophthalmologist using the slit-lamp bio microscope and indirect ophthalmoscope.Visual impairment of criteria 1 sensitivity was 93% and specificity was 91%. Moreover, the likelihood ratio of positive results was 11 and negative result was 0.05. For the criteria 2 the sensitivity was 97% and specificity was 86%. Moreover, the likelihood of positive results was 6 and negative result was 0.02. Apart from this detection of potentially remedial visual impairment sensitivity was 69% and specificity was 91%. The likelihood ratio of positive result was 8 and negative result was 0.2.The vision test and proper ocular examination were underestimated the extent of vision impairment in older adults. As per the outcome of the study, the visual impairment is common in elderly patients with a history of falls. Moreover, the study has suggested that to measure the visual acuity of all elderly patients recuperating from a proximal hip fracture after a simple fall.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"4 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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