Pub Date : 2023-12-15DOI: 10.18231/j.pjms.2023.138
Ramesh Kumar Biswal, Siba Prasad Das, Kaushik Mishra, A. Pradhan
New born mortality is a public health problem in the state of Odisha. Newborn mortality is a dynamic process and variations in mortality are observed temporally and seasonally, and also across health facilities. Prior knowledge of mortality burden can enable health system’s readiness in terms of resources allocation and timely intervention, thereby improving the chances of survival of sick newborns admitted in the hospitals. Hence, this study aimed to examine temporal trends of newborn mortality in a Special Newborn Care Unit of Saheed Laxman Nayak Medical College and Hospital (SLNMCH) in Odisha and forecast a short-term monthly projection.The Box-Jenkins approach was used to fit a seasonal autoregressive integrated moving average (SARIMA) model to the monthly recorded mortality among the hospitalized new borns in the SNCU during 2016-2020. The best-fit model for forecasting was found based on the Akaike Information Criterion.The time-series analysis revealed a modest upward trend in newborn mortality rate among SNCU admitted newborns, with peaks in the late winter and late summer months. The seasonal ARIMA (0,1,1)(1,1,1)12 model offered the best fit for time-series data. This model predicted the monthly percentage of mortality in SNCU admitted newborns in the range of 9% to 35% with respective 95% confidence interval for two years period (2021-2022).SARIMA models are useful for monitoring newborn mortality and provide an estimate of temporal trends and seasonality. The models are helpful for predicting occurrence of mortality in the SNCU of SLNMCH and could be useful for developing early warning systems. It may help in early detection, timely treatment, and prevention of serious complications in admitted sick newborns.
{"title":"Forecasting of neonatal mortality trend at a special new-born care unit in Odisha, India: A time-series analysis","authors":"Ramesh Kumar Biswal, Siba Prasad Das, Kaushik Mishra, A. Pradhan","doi":"10.18231/j.pjms.2023.138","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.138","url":null,"abstract":"New born mortality is a public health problem in the state of Odisha. Newborn mortality is a dynamic process and variations in mortality are observed temporally and seasonally, and also across health facilities. Prior knowledge of mortality burden can enable health system’s readiness in terms of resources allocation and timely intervention, thereby improving the chances of survival of sick newborns admitted in the hospitals. Hence, this study aimed to examine temporal trends of newborn mortality in a Special Newborn Care Unit of Saheed Laxman Nayak Medical College and Hospital (SLNMCH) in Odisha and forecast a short-term monthly projection.The Box-Jenkins approach was used to fit a seasonal autoregressive integrated moving average (SARIMA) model to the monthly recorded mortality among the hospitalized new borns in the SNCU during 2016-2020. The best-fit model for forecasting was found based on the Akaike Information Criterion.The time-series analysis revealed a modest upward trend in newborn mortality rate among SNCU admitted newborns, with peaks in the late winter and late summer months. The seasonal ARIMA (0,1,1)(1,1,1)12 model offered the best fit for time-series data. This model predicted the monthly percentage of mortality in SNCU admitted newborns in the range of 9% to 35% with respective 95% confidence interval for two years period (2021-2022).SARIMA models are useful for monitoring newborn mortality and provide an estimate of temporal trends and seasonality. The models are helpful for predicting occurrence of mortality in the SNCU of SLNMCH and could be useful for developing early warning systems. It may help in early detection, timely treatment, and prevention of serious complications in admitted sick newborns.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"25 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Ziehl-Neelsen staining method though it plays an important role in detecting acid fast bacilli (AFB) by direct microscopy its low sensitivity makes to look for the other alternatives. : This study was undertaken to evaluate the utility of auto fluorescence method on Papanicolaou stain (Pap) in comparison tothe traditional Ziehl-Neelsen stain (ZN) method in detection of AFB from lymph node aspirates. Fine needle aspirations (FNAs) were done in 153 patients with clinical suspicion of tubercular lymphadenitis. Smears from aspirate were processed for routine cytology for Hematoxyllin & Eosin (H&E), Giemsa, Pap, Ziehl-Neelsen (ZN) and Auramine (AR) staining. Pap stained smears were examined for AFB for their autofluorescence under fluorescent microscope using the blue excitation filter. ZN stained smears are examined for AFB under oil immersion of compound microscope. The efficacy of the autofluorescence method by Pap in detection of acid fast bacilli (AFB) over the conventional Ziehl-Neelsen stain was analyzed by taking AR as a standard control for AFB.Tuberculous lymphadenitis was diagnosed in 36 cases out of 153 clinicall suspected cases by cytology, culture and microscopyThe sensitivity of ZN was 57.14% and specificity was 99.15% while the sensitivity of AF was 96.5% and the specificity was 91.8%. : It was a novel method of detection of AFB, cheaper, easily available and less time consuming than other methods. AR also had high sensitivity rates as AF.
{"title":"Comparision of pap stained smears by using auto fluorescence method with ziehl-neelsen method for detection of acid fast bacilli (AFB)","authors":"Yerraguntla Divya Prafulla, Sameeranandana Reddy, Yerraguntla Shashidhar","doi":"10.18231/j.pjms.2023.124","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.124","url":null,"abstract":"The Ziehl-Neelsen staining method though it plays an important role in detecting acid fast bacilli (AFB) by direct microscopy its low sensitivity makes to look for the other alternatives. : This study was undertaken to evaluate the utility of auto fluorescence method on Papanicolaou stain (Pap) in comparison tothe traditional Ziehl-Neelsen stain (ZN) method in detection of AFB from lymph node aspirates. Fine needle aspirations (FNAs) were done in 153 patients with clinical suspicion of tubercular lymphadenitis. Smears from aspirate were processed for routine cytology for Hematoxyllin & Eosin (H&E), Giemsa, Pap, Ziehl-Neelsen (ZN) and Auramine (AR) staining. Pap stained smears were examined for AFB for their autofluorescence under fluorescent microscope using the blue excitation filter. ZN stained smears are examined for AFB under oil immersion of compound microscope. The efficacy of the autofluorescence method by Pap in detection of acid fast bacilli (AFB) over the conventional Ziehl-Neelsen stain was analyzed by taking AR as a standard control for AFB.Tuberculous lymphadenitis was diagnosed in 36 cases out of 153 clinicall suspected cases by cytology, culture and microscopyThe sensitivity of ZN was 57.14% and specificity was 99.15% while the sensitivity of AF was 96.5% and the specificity was 91.8%. : It was a novel method of detection of AFB, cheaper, easily available and less time consuming than other methods. AR also had high sensitivity rates as AF.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"75 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.pjms.2023.143
M. Periyanayagi, Uma Velpandian, A. Mohankumar
Tuberculosis is an airborne infectious illness caused by Mycobacterium tuberculosis, and it is the most common cause of morbidity and mortality worldwide. Extra-pulmonary TB, often known as ocular tuberculosis, can occur alone or in conjunction with pulmonary tuberculosis. Tuberculosis of the eye can be caused by an active infection or a type 4 hypersensitivity reaction.Aim: To investigate the role of antituberculous therapy in the treatment of suspected intraocular tuberculosis. Based on a clinical diagnosis of Ocular tuberculosis, 46 patients were assessed with a chest X-ray, Mx test, and quantiferon gold assay and treated with ATT. The results showed that out of 46 patients, 29 were females and 17 were males. There were 34 patients with B/L involvement and 12 with U/L involvement. In addition, 76 percent of individuals tested positive for tuberculin on their skin, indicating latent tuberculosis. Quantiferon gold assay was positive in 19.56 percent of patients. On X-ray chest, 17.3% of patients had a healed old tuberculosis lesion. H/O contact with TB family members was reported in 13.04 percent of patients. All patients who had ATT therapy had a favourable outcome, with inflammation clearance and non-recurrence.
结核病是由结核分枝杆菌引起的一种空气传播传染病，是全球最常见的发病和死亡原因。肺外结核通常被称为眼结核，可单独发生，也可与肺结核同时发生。眼结核可由活动性感染或 4 型超敏反应引起。目的：探讨抗结核治疗在治疗疑似眼结核中的作用。根据眼结核的临床诊断，对 46 名患者进行了胸部 X 光检查、Mx 试验和定量金测定，并对其进行了抗结核治疗。结果显示，46 名患者中，女性 29 人，男性 17 人。有 34 名患者受 B/L 病毒感染，12 名患者受 U/L 病毒感染。此外，76%的患者皮肤结核菌素检测呈阳性，表明存在潜伏结核病。19.56%的患者定量金检测呈阳性。在胸部 X 光检查中，17.3% 的患者有已愈合的陈旧性结核病灶。据报告，13.04%的患者曾与肺结核家庭成员接触。所有接受过 ATT 治疗的患者均取得了良好的疗效，炎症清除且不再复发。
{"title":"Role of antituberculous therapy in latent tuberculosis with ocular manifestations","authors":"M. Periyanayagi, Uma Velpandian, A. Mohankumar","doi":"10.18231/j.pjms.2023.143","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.143","url":null,"abstract":"Tuberculosis is an airborne infectious illness caused by Mycobacterium tuberculosis, and it is the most common cause of morbidity and mortality worldwide. Extra-pulmonary TB, often known as ocular tuberculosis, can occur alone or in conjunction with pulmonary tuberculosis. Tuberculosis of the eye can be caused by an active infection or a type 4 hypersensitivity reaction.Aim: To investigate the role of antituberculous therapy in the treatment of suspected intraocular tuberculosis. Based on a clinical diagnosis of Ocular tuberculosis, 46 patients were assessed with a chest X-ray, Mx test, and quantiferon gold assay and treated with ATT. The results showed that out of 46 patients, 29 were females and 17 were males. There were 34 patients with B/L involvement and 12 with U/L involvement. In addition, 76 percent of individuals tested positive for tuberculin on their skin, indicating latent tuberculosis. Quantiferon gold assay was positive in 19.56 percent of patients. On X-ray chest, 17.3% of patients had a healed old tuberculosis lesion. H/O contact with TB family members was reported in 13.04 percent of patients. All patients who had ATT therapy had a favourable outcome, with inflammation clearance and non-recurrence.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138970747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.pjms.2023.103
M. Murmu, Subas Chandra Majhi, Himansu Nayak, Sameer Kiro, Swagat Das, Shitanshu Kumar Meher, Sanjukta Panda
: Childhood asthma has a hazardous impact on the growth, social & emotional aspect of the life thereby affecting the quality of life. Hence, early diagnosis & identification of symptoms can help prevent the co-morbidities. High sensitive C-Reactive protein (hsCRP) a known marker of systemic inflammation is evaluated in the current study as a marker of asthma in the preschool children.To evaluate the efficacy of serum hsCRP as a diagnostic marker & to find out the correlation of serum hsCRP level among the different grades of severity of asthma in pre-school children.A cross-sectional analytical study was designed with 811 samples equally divided between the case & health matched control groups.GINA-2018 definition was used to recruit subjects & classify the severity. One time serum hsCRP was estimated in the subjects among both the cases & controls, & correlated with other variables in the study.A total of 811 participants were included in the final analysis with 402participants in asthmatics category & 409 participants in healthy children category. Out of the 402 asthmatics,362 (90.05%) subjects tested to be positive(higher than 3mg/L) & only 40 subjects (9.95%) were negative. Similarly out of 409 healthy subjects, only 36 (8.8%) were positive while majority i.e. 373(91.2%) were found to be negative. The test was evaluated to be having a sensitivity of 90.05%, specificity of93.32% with a diagnostic accuracy of 91.66%. The diagnostic accuracy of hsCRP in severe asthma was 63%, & the specificity was 58%, whereas in case of mild asthma it was79% & 73% respectively with statistical significance. hsCRP is a reliable diagnostic marker in preschool asthmatics to besides clinical correlates.
{"title":"A study on high sensitive C-Reactive protein as a diagnostic marker in preschool asthmatics","authors":"M. Murmu, Subas Chandra Majhi, Himansu Nayak, Sameer Kiro, Swagat Das, Shitanshu Kumar Meher, Sanjukta Panda","doi":"10.18231/j.pjms.2023.103","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.103","url":null,"abstract":": Childhood asthma has a hazardous impact on the growth, social & emotional aspect of the life thereby affecting the quality of life. Hence, early diagnosis & identification of symptoms can help prevent the co-morbidities. High sensitive C-Reactive protein (hsCRP) a known marker of systemic inflammation is evaluated in the current study as a marker of asthma in the preschool children.To evaluate the efficacy of serum hsCRP as a diagnostic marker & to find out the correlation of serum hsCRP level among the different grades of severity of asthma in pre-school children.A cross-sectional analytical study was designed with 811 samples equally divided between the case & health matched control groups.GINA-2018 definition was used to recruit subjects & classify the severity. One time serum hsCRP was estimated in the subjects among both the cases & controls, & correlated with other variables in the study.A total of 811 participants were included in the final analysis with 402participants in asthmatics category & 409 participants in healthy children category. Out of the 402 asthmatics,362 (90.05%) subjects tested to be positive(higher than 3mg/L) & only 40 subjects (9.95%) were negative. Similarly out of 409 healthy subjects, only 36 (8.8%) were positive while majority i.e. 373(91.2%) were found to be negative. The test was evaluated to be having a sensitivity of 90.05%, specificity of93.32% with a diagnostic accuracy of 91.66%. The diagnostic accuracy of hsCRP in severe asthma was 63%, & the specificity was 58%, whereas in case of mild asthma it was79% & 73% respectively with statistical significance. hsCRP is a reliable diagnostic marker in preschool asthmatics to besides clinical correlates.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"21 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.pjms.2023.123
G. Elavazhagan, V. Prakash
Chronic alcohol intake can lead to functional disturbances and irreversible lesions in organs such as the liver, brain, pancreas, gastrointestinal tract, heart, and endocrine gland. Determining the serum activities of various enzymes such as aminotransferases, glutamate dehydrogenase (GDH), and gamma-glutamyltransferase (GGT) has widely been used as a method of screening for hepatic involvement in chronic alcoholism.This study was conducted to analyze multiple serum enzyme level changes in a chronic alcoholic with special reference to GGT and lipid peroxidase34 subjects were selected for the study. They are all male individuals with a positive history of chronic alcohol abuse. 10 healthy male volunteers who matched in age and socioeconomic status served as the controls.: The activity of serum enzyme levels in test and control groups has been statistically analyzed. There was a highly significant difference (p<0.001) in the mean values of the Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), GGT of these two groups, whereas Serum lipid peroxidase (SLP) was less significant (p<0.01). The concentration of GGT was significantly low (p<0.001) in controls compared to that in the alcoholics.GGT can be taken as a marker of chronic alcoholism, provided serum bilirubin, SAP is within the reasonably average level
{"title":"Multiple serum enzyme level changes in chronic alcoholic with special reference to gamma-glutamyl transpeptidase and lipid peroxidase","authors":"G. Elavazhagan, V. Prakash","doi":"10.18231/j.pjms.2023.123","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.123","url":null,"abstract":"Chronic alcohol intake can lead to functional disturbances and irreversible lesions in organs such as the liver, brain, pancreas, gastrointestinal tract, heart, and endocrine gland. Determining the serum activities of various enzymes such as aminotransferases, glutamate dehydrogenase (GDH), and gamma-glutamyltransferase (GGT) has widely been used as a method of screening for hepatic involvement in chronic alcoholism.This study was conducted to analyze multiple serum enzyme level changes in a chronic alcoholic with special reference to GGT and lipid peroxidase34 subjects were selected for the study. They are all male individuals with a positive history of chronic alcohol abuse. 10 healthy male volunteers who matched in age and socioeconomic status served as the controls.: The activity of serum enzyme levels in test and control groups has been statistically analyzed. There was a highly significant difference (p<0.001) in the mean values of the Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), GGT of these two groups, whereas Serum lipid peroxidase (SLP) was less significant (p<0.01). The concentration of GGT was significantly low (p<0.001) in controls compared to that in the alcoholics.GGT can be taken as a marker of chronic alcoholism, provided serum bilirubin, SAP is within the reasonably average level","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"44 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: For audiological prosthesis surgery morphometry of stapes is of utmost importance. Previous studies were mainly based on foreign and northern Indian population. Hence the present study.: To measure the morphometric parameters of stapes and compare the same with the previous studies.: This cross sectional observational study, performed on the ear ossicle, stapes obtained from 26 cadaveric heads. A total of (26 x 2) = 52 sets of stapes were taken out for the study. Measurements of various parameters of the ossicles were done with micrometer. Comparison among them with respect to sex, laterality and race were made. Age variation was not considered as the ossicles reach their full size at birth. Statistically significant difference in the total height of stapes was observed between male and female ossicles, but no such disparity was found between ossicles of the two sides. Height of stapes in males (mean: 3.35mm) was found to be significantly higher (p value: 0.00001) as compared to females (mean:3.18mm) in this present study. In surgeries for otosclerosis, the stapes superstructure is removed and replaced by a prosthetic ‘piston’, the selection of which is determined by the distance between the lenticular process of incus and the footplate of stapes, which in turn corresponds to the height of stapes superstructure. This measurement is vital for a properly fit piston and thus to the outcome of the surgery in terms of hearing improvement and lack of complications like expulsion of the piston, intractable vertigo, etc. When the mean values found in this study were compared with those of previous foreign and Indian studies, some of the values were found to be similar. : The height of stapes was shorter in our study as compared to studies based on North Indian population. These differences might point towards geographic or ethnic variations in the stapes which might call for further research work into this topic.
:镫骨形态测量对于听力假体手术至关重要。以往的研究主要基于外国和印度北部人群。因此，本研究测量镫骨的形态参数，并与以往的研究进行比较：这项横断面观察性研究对从 26 个尸体头部获得的耳骨--镫骨进行了测量。研究共取出（26 x 2）=52组镫骨。用千分尺测量了听小骨的各种参数。比较了它们的性别、侧位和种族。由于听小骨在出生时就已长满，因此不考虑年龄差异。据统计，男性和女性听小骨之间的镫骨总高度差异很大，但两侧听小骨之间没有发现这种差异。本研究发现，男性镫骨的高度（平均值：3.35 毫米）明显高于女性（平均值：3.18 毫米）（P 值：0.00001）。在治疗耳硬化症的手术中，镫骨上部结构被移除，取而代之的是一个假体 "活塞"，活塞的选择取决于切迹的透镜突与镫骨脚板之间的距离，而切迹的透镜突与镫骨脚板之间的距离又与镫骨上部结构的高度相对应。该测量值对于活塞的正确安装至关重要，因此对于手术效果（听力改善、无活塞脱出、顽固性眩晕等并发症）也至关重要。将本研究中发现的平均值与之前的国外和印度研究中的平均值进行比较时，发现其中一些值是相似的：与基于北印度人群的研究相比，我们的研究中镫骨的高度较短。这些差异可能表明镫骨存在地理或种族差异，这可能需要对这一主题开展进一步的研究工作。
{"title":"Morphometric study of stapes and its variation in Eastern Indian population","authors":"Susmita Ghosh, Ritaban Saha, Subhajit Halder, Oyndrila Sengupta","doi":"10.18231/j.pjms.2023.105","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.105","url":null,"abstract":": For audiological prosthesis surgery morphometry of stapes is of utmost importance. Previous studies were mainly based on foreign and northern Indian population. Hence the present study.: To measure the morphometric parameters of stapes and compare the same with the previous studies.: This cross sectional observational study, performed on the ear ossicle, stapes obtained from 26 cadaveric heads. A total of (26 x 2) = 52 sets of stapes were taken out for the study. Measurements of various parameters of the ossicles were done with micrometer. Comparison among them with respect to sex, laterality and race were made. Age variation was not considered as the ossicles reach their full size at birth. Statistically significant difference in the total height of stapes was observed between male and female ossicles, but no such disparity was found between ossicles of the two sides. Height of stapes in males (mean: 3.35mm) was found to be significantly higher (p value: 0.00001) as compared to females (mean:3.18mm) in this present study. In surgeries for otosclerosis, the stapes superstructure is removed and replaced by a prosthetic ‘piston’, the selection of which is determined by the distance between the lenticular process of incus and the footplate of stapes, which in turn corresponds to the height of stapes superstructure. This measurement is vital for a properly fit piston and thus to the outcome of the surgery in terms of hearing improvement and lack of complications like expulsion of the piston, intractable vertigo, etc. When the mean values found in this study were compared with those of previous foreign and Indian studies, some of the values were found to be similar. : The height of stapes was shorter in our study as compared to studies based on North Indian population. These differences might point towards geographic or ethnic variations in the stapes which might call for further research work into this topic.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"47 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Complete spectrum of covid 19 infection in children as well as its sequaele is still unknown to the world even after two years of ongoing pandemic. Many manifestations of covid 19 have been missed and are yet to be identified. In this study, we aim to hypothesize hepatitis as a probable late manifestation of COVID-19 infection in children. It was a descriptive retrospective study, in which we have included twenty patients who presented with hepatitis in the pediatric department of a secondary level care centre in Sagar from May to July 2021. And we investigated them further to find out the cause of Hepatitis. Among the 20 patients with HEPATITIS, 15 were tested for covid antibody levels, out of them 14 had raised level of SARS-CoV-2 antibody titre. Pediatricians should recognize that the clinical spectrum of COVID-19 in children can be wider than previously described, often with hepatitis as late manifestation of COVID-19 in children, apart from MIS-C.
{"title":"Hepatitis –A late manifestation of COVID-19 in pediatric population?","authors":"Roopa Agrawal, Gaurav Agarwal, Rupesh Sahu, Ashish Jain, Deepesh Asati, S. Rawat","doi":"10.18231/j.pjms.2023.131","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.131","url":null,"abstract":"Complete spectrum of covid 19 infection in children as well as its sequaele is still unknown to the world even after two years of ongoing pandemic. Many manifestations of covid 19 have been missed and are yet to be identified. In this study, we aim to hypothesize hepatitis as a probable late manifestation of COVID-19 infection in children. It was a descriptive retrospective study, in which we have included twenty patients who presented with hepatitis in the pediatric department of a secondary level care centre in Sagar from May to July 2021. And we investigated them further to find out the cause of Hepatitis. Among the 20 patients with HEPATITIS, 15 were tested for covid antibody levels, out of them 14 had raised level of SARS-CoV-2 antibody titre. Pediatricians should recognize that the clinical spectrum of COVID-19 in children can be wider than previously described, often with hepatitis as late manifestation of COVID-19 in children, apart from MIS-C.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.pjms.2023.156
Anirban Chatterjee, Subham Bhattacharya, M. Sinha
The corpus callosum is the largest connective fiber between two hemispheres and a crucial structure for the integrated cerebral function of the normal brain. The study of agenesis of the corpus callosum (ACC) develops insights into neurodevelopmental delays and autism in children. This is a case series of eight children with ACC confirmed by a neuroimaging in a teaching hospital. The clinico-neuroradiological profile of ACC were studied retrospectively and reviewed clinical correlation with neuroradioimaging in the light of neuropathophysiology knowledge.The study group was appeared as nonsyndromic. Every subject had a normal chromosomal study by karyotyping. These ACC patients neither had a specific recognizable syndrome nor the constellation of malformations are indicative of a disorder. The mean age of subjects was 21.3 months, and no predilection for gender. The global developmental delay was the most common presentation found in seven ACC (87.5%) children. The second commonest, four ACC (50%) patients, was seizure. Two ACC (25%) had colpocephaly. Five ACC children (62.5%) had somatic anomalies; four ACC (50%) patients had cardiac defects.ACC children present a poor neurodevelopmental outcome. The extracallosal brain anomaly determines a worse neurological prognosis in nonsyndromic ACC. Grey matter heterotopia in neuroimaging was associated with seizure in ACC children. However, colpocephaly along with ACC may present with normal neurodevelopment. Hence, ACC in neuroimaging may have not predicted the final neurological outcome.ACC children with normal karyotyping may have somatic malformations. Moreover, echocardiography can be considered an initial routine screening in nonsyndromic ACC children.
{"title":"A case series of agenesis of the corpus callosum in children - Clinical and neuroimaging correlation with aspects of neuropathophysiology","authors":"Anirban Chatterjee, Subham Bhattacharya, M. Sinha","doi":"10.18231/j.pjms.2023.156","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.156","url":null,"abstract":"The corpus callosum is the largest connective fiber between two hemispheres and a crucial structure for the integrated cerebral function of the normal brain. The study of agenesis of the corpus callosum (ACC) develops insights into neurodevelopmental delays and autism in children. This is a case series of eight children with ACC confirmed by a neuroimaging in a teaching hospital. The clinico-neuroradiological profile of ACC were studied retrospectively and reviewed clinical correlation with neuroradioimaging in the light of neuropathophysiology knowledge.The study group was appeared as nonsyndromic. Every subject had a normal chromosomal study by karyotyping. These ACC patients neither had a specific recognizable syndrome nor the constellation of malformations are indicative of a disorder. The mean age of subjects was 21.3 months, and no predilection for gender. The global developmental delay was the most common presentation found in seven ACC (87.5%) children. The second commonest, four ACC (50%) patients, was seizure. Two ACC (25%) had colpocephaly. Five ACC children (62.5%) had somatic anomalies; four ACC (50%) patients had cardiac defects.ACC children present a poor neurodevelopmental outcome. The extracallosal brain anomaly determines a worse neurological prognosis in nonsyndromic ACC. Grey matter heterotopia in neuroimaging was associated with seizure in ACC children. However, colpocephaly along with ACC may present with normal neurodevelopment. Hence, ACC in neuroimaging may have not predicted the final neurological outcome.ACC children with normal karyotyping may have somatic malformations. Moreover, echocardiography can be considered an initial routine screening in nonsyndromic ACC children.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"83 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.pjms.2023.152
Plabon Hazarika, Prabal Bharali, Biswadeep Choudhury, Oreyjeet Das, S. Vignesh
The initial interaction between patients and anaesthesiologists during pre-anaesthesia check-ups (PAC) is a crucial opportunity to diagnose and pre-optimize co-morbidities that might go unnoticed. This proactive approach contributes to safe anaesthesia administration, uneventful intra-operative experiences, and smooth post-operative recovery. Our study assesses the prevalence of diverse co-morbidities within a tertiary care centre's PAC. After analysing data from 3 months involving 905 patients, 624 individuals exhibited co-morbidities, with 217 cases being newly identified within the PAC clinic. Among female patients, anaemia emerged as the most prevalent anomaly (219 cases), while hypertension dominated among male patients (171 cases). Overall, anaemia constituted the most common co-morbidity (362 cases). A comprehensive clinical assessment during the Pre-Anaesthetic Clinic empowers formulation strategies for pre-optimization and treatment of co-morbidities. Timely intervention is pivotal, not only to prevent surgery delays but also to avert potentially catastrophic outcomes arising from untreated conditions. This approach translates into expedited patient recovery, minimizing anaesthesia-related complications. The Pre-Anaesthetic Clinic plays a pivotal role in diagnosing and intervening in patient co-morbidities. Beyond diagnosis, it is a crucial early intervention and treatment platform, significantly enhancing the overall surgical recovery process.
{"title":"Prevalence of co-morbidities and referral patterns in routine preoperative evaluation: A retrospective observational analysis in a tertiary care government hospital","authors":"Plabon Hazarika, Prabal Bharali, Biswadeep Choudhury, Oreyjeet Das, S. Vignesh","doi":"10.18231/j.pjms.2023.152","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.152","url":null,"abstract":"The initial interaction between patients and anaesthesiologists during pre-anaesthesia check-ups (PAC) is a crucial opportunity to diagnose and pre-optimize co-morbidities that might go unnoticed. This proactive approach contributes to safe anaesthesia administration, uneventful intra-operative experiences, and smooth post-operative recovery. Our study assesses the prevalence of diverse co-morbidities within a tertiary care centre's PAC. After analysing data from 3 months involving 905 patients, 624 individuals exhibited co-morbidities, with 217 cases being newly identified within the PAC clinic. Among female patients, anaemia emerged as the most prevalent anomaly (219 cases), while hypertension dominated among male patients (171 cases). Overall, anaemia constituted the most common co-morbidity (362 cases). A comprehensive clinical assessment during the Pre-Anaesthetic Clinic empowers formulation strategies for pre-optimization and treatment of co-morbidities. Timely intervention is pivotal, not only to prevent surgery delays but also to avert potentially catastrophic outcomes arising from untreated conditions. This approach translates into expedited patient recovery, minimizing anaesthesia-related complications. The Pre-Anaesthetic Clinic plays a pivotal role in diagnosing and intervening in patient co-morbidities. Beyond diagnosis, it is a crucial early intervention and treatment platform, significantly enhancing the overall surgical recovery process.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"106 S6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The novel coronavirus (COVID-19) pandemic has infected millions worldwide. Preventive interventions are beneficial to mitigate transmission, containment of the disease, and stop the resurgence of another wave of the pandemic. A cross-sectional study was done among non-teaching staff, aged 18 years or above willing to voluntarily participate to assess knowledge and practice of face masks during the COVID-19 pandemic in a tertiary health care center. we also addressed the need for the use of face masks even after the vaccination is done. Subjects demonstrated good knowledge about transmission and practice of preventive measures for COVID-19. Among those, who were always (100%) using masks, marital status, education, and occupation had a significant association with the frequency of use of masks. While those, who were mostly (>50%) using masks, marital status, and education were significant determinants of the frequency of use of masks. The study highlighted the importance of knowledge and appropriate practice of the use of masks, which can help policymakers to predict success & make necessary modifications based on it, to stop transmission and fluctuation in the declining phase of covid-19 pandemic.
{"title":"Knowledge and practice of masks during COVID-19 among non-teaching staff in a tertiary health care Centre, India","authors":"Poonam Kushwaha, Ashish Pundhir, Anju Gahlot, Lakshmi Singh","doi":"10.18231/j.pjms.2023.144","DOIUrl":"https://doi.org/10.18231/j.pjms.2023.144","url":null,"abstract":"The novel coronavirus (COVID-19) pandemic has infected millions worldwide. Preventive interventions are beneficial to mitigate transmission, containment of the disease, and stop the resurgence of another wave of the pandemic. A cross-sectional study was done among non-teaching staff, aged 18 years or above willing to voluntarily participate to assess knowledge and practice of face masks during the COVID-19 pandemic in a tertiary health care center. we also addressed the need for the use of face masks even after the vaccination is done. Subjects demonstrated good knowledge about transmission and practice of preventive measures for COVID-19. Among those, who were always (100%) using masks, marital status, education, and occupation had a significant association with the frequency of use of masks. While those, who were mostly (>50%) using masks, marital status, and education were significant determinants of the frequency of use of masks. The study highlighted the importance of knowledge and appropriate practice of the use of masks, which can help policymakers to predict success & make necessary modifications based on it, to stop transmission and fluctuation in the declining phase of covid-19 pandemic.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"69 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：