Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.035
Santa Subhra Chatterjee, Amitava Mazumdar, Soumik Mandal
Considering sepsis as a common illness the following study studied the score and extrapolated with survival benefits in medical emergency patients. The score was made to determine population level burden of disease.Various studies recommended SOFA for screening sepsis and determine prognosis. The score has been used to determine injury to organs in admitted patients with infection. The cross sectional study was conducted at Vivekananda Institute of Medical Sciences, Kolkata over a period of one year (2019 till 2020) on sepsis patients admitted in medical ICU. The study revealed that more the scores on the day of admission, the more is the risk of adverse outcomes and subsequent early mortality (within day 7 of admission). In this study, among 56 cases of total death within the first 7 days of admission, 53 patients (94.64%) had day 0 SOFA score of >9 making it a significant outcome in this study. Baseline SOFA scores ≥ 9 and rising SOFA scores as day progresses can predict mortality in sepsis. The mean SOFA score on admission to the ICU was 9.2. The 28-day mortality rate was 28%. Patients with a SOFA score of 9 or more on admission to the ICU had a significantly higher mortality rate than those with a score of less than 9 (42% vs. 14%, p < 0.01). The SOFA score on day 3 of ICU stay was also significantly associated with mortality (p < 0.01). The SOFA score is a simple and easy-to-use tool that can be used to assess the severity of organ dysfunction in patients with sepsis. It is a good predictor of mortality in patients with sepsis admitted to the ICU.
{"title":"Evaluation of SOFA score (Sequential Organ Failure Assessment score) in hospitalised patients with sepsis","authors":"Santa Subhra Chatterjee, Amitava Mazumdar, Soumik Mandal","doi":"10.18231/j.pjms.2024.035","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.035","url":null,"abstract":"Considering sepsis as a common illness the following study studied the score and extrapolated with survival benefits in medical emergency patients. The score was made to determine population level burden of disease.Various studies recommended SOFA for screening sepsis and determine prognosis. The score has been used to determine injury to organs in admitted patients with infection. The cross sectional study was conducted at Vivekananda Institute of Medical Sciences, Kolkata over a period of one year (2019 till 2020) on sepsis patients admitted in medical ICU. The study revealed that more the scores on the day of admission, the more is the risk of adverse outcomes and subsequent early mortality (within day 7 of admission). In this study, among 56 cases of total death within the first 7 days of admission, 53 patients (94.64%) had day 0 SOFA score of >9 making it a significant outcome in this study. Baseline SOFA scores ≥ 9 and rising SOFA scores as day progresses can predict mortality in sepsis. The mean SOFA score on admission to the ICU was 9.2. The 28-day mortality rate was 28%. Patients with a SOFA score of 9 or more on admission to the ICU had a significantly higher mortality rate than those with a score of less than 9 (42% vs. 14%, p < 0.01). The SOFA score on day 3 of ICU stay was also significantly associated with mortality (p < 0.01). The SOFA score is a simple and easy-to-use tool that can be used to assess the severity of organ dysfunction in patients with sepsis. It is a good predictor of mortality in patients with sepsis admitted to the ICU.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"21 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Functional endoscopic sinus surgery (FESS) is a surgical technique to treat sinonasal diseases. Intraoperative bleeding is one of the major challenges, which hinder the confined area of visibility and prolongs the procedure. Intraoperative induced hypotension can reduce intraoperative bleeding, to provide clear surgical field for dissection and hence decreasing operative time. So, we compared effect of dexmedetomidine and propofol infusion on the intraoperative haemodynamics during functional endoscopic sinus surgery (FESS). To study the effect of intravenous (IV) dexmedetomidine and propofol infusion on intraoperative haemodynamics under general anaesthesia in functional endoscopic sinus surgery(FESS). Secondary aim was to study estimated blood loss if any. To study the effect of I.V. dexmedetomidine and propofol infusion on intraoperative haemodynamics under general anaesthesia in functional endoscopic sinus surgery (FESS). Patients were divided randomly by sealed envelope method into two groups with 30 patients in each group. Group D patients received dexmedetomidine 1ug/kg as a loading dose over 20 minutes followed by 0.3 ug/kg/hr infusion for maintainence. Group P patients received propofol 2mg/kg as a loading dose followed by 100-200 ug/kg/min infusion for maintenance. The findings in our study highlights that dexmedetomidine infusion decreases haemodynamic parameters like arterial blood pressure and heart rate more as compared to propofol infusion during FESS. The effect on hemodynamics sustained and consistent without requirement of additional hypotensive agents. So altogether, this lead to better surgical field. Use of dexmedetomidine is a safe and effective method to control bleeding and improve the quality of surgical field and intraoperative haemodynamics.
{"title":"Comparison of dexmedetomidine and propofol infusion on intraoperative haemodynamics during functional endoscopic sinus surgery under general anaesthesia- A randomized controlled trial","authors":"Sahil Garg, Hersimranjit Kaur, Amandeep Singh, Pankaj Bansal, Manvi Garg, Seema Prasad","doi":"10.18231/j.pjms.2024.021","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.021","url":null,"abstract":"Functional endoscopic sinus surgery (FESS) is a surgical technique to treat sinonasal diseases. Intraoperative bleeding is one of the major challenges, which hinder the confined area of visibility and prolongs the procedure. Intraoperative induced hypotension can reduce intraoperative bleeding, to provide clear surgical field for dissection and hence decreasing operative time. So, we compared effect of dexmedetomidine and propofol infusion on the intraoperative haemodynamics during functional endoscopic sinus surgery (FESS). To study the effect of intravenous (IV) dexmedetomidine and propofol infusion on intraoperative haemodynamics under general anaesthesia in functional endoscopic sinus surgery(FESS). Secondary aim was to study estimated blood loss if any. To study the effect of I.V. dexmedetomidine and propofol infusion on intraoperative haemodynamics under general anaesthesia in functional endoscopic sinus surgery (FESS). Patients were divided randomly by sealed envelope method into two groups with 30 patients in each group. Group D patients received dexmedetomidine 1ug/kg as a loading dose over 20 minutes followed by 0.3 ug/kg/hr infusion for maintainence. Group P patients received propofol 2mg/kg as a loading dose followed by 100-200 ug/kg/min infusion for maintenance. The findings in our study highlights that dexmedetomidine infusion decreases haemodynamic parameters like arterial blood pressure and heart rate more as compared to propofol infusion during FESS. The effect on hemodynamics sustained and consistent without requirement of additional hypotensive agents. So altogether, this lead to better surgical field. Use of dexmedetomidine is a safe and effective method to control bleeding and improve the quality of surgical field and intraoperative haemodynamics.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Retinopathy of rashness (ROP) is a critical reason for youth visual deficiency which gives a window period to screening & treatment prior to advancing to an extreme structure having poor visual result. Universally, no less than 50,000 kids are visually impaired because of ROP & an extra obscure number will be outwardly impeded or blind in one eye. To evaluate the administration of patients with Retinopathy of rashness & its result of the treatment applied in a tertiary level neonatal unit in the territory of Odisha. It is a clinic based unmistakable (cross-sectional) study, done from September 2019 to October 2021 done at SNCU of SCBMCH, Cuttack & SNCU, NICU of Sardar Vallabh bhai Patel Postgraduate Foundation of Pediatrics (SVPPGIP), Cuttack, Odisha who qualify the incorporation standards. During the review time of almost 2 years, 310 children were evaluated for ROP in which 117 were viewed as sure for ROP. The frequency of ROP in our review was 37.7%. ROP is viewed as related with the accompanying gamble factors in our review like low gestational age, low birth weight, oxygen treatment, RDS, paleness, blood bonding & septicemia, numerous births, hyperbilirubinemia with low birth weight & low gestational age & oxygen treatment being the main ones. Out of 31 cases treated with Avastin infusion, 26 gave indications of relapse till 2 months follow up & just 5 of them didn't give indications of relapse after infusion Bevacizumab. Those 5 children were treated with retinal removal by LASER photocoagulation following 10 days of beginning treatment, who gave indications of relapse till 2 months follow up. Legitimate screening & the executives of ROP can prompt counteraction of movement of infection to a more extreme stage with poor visual guess, consequently decreasing the weight of experience growing up visual deficiency. Intra vitreal hostile to VEGF infusion can be utilized as essential treatment for treatment justified ROP cases however more examination is expected to figure out the drawn out incidental effect profile of these medications.
{"title":"A study on the management of patients with retinopathy of prematurity in a tertiary care setting","authors":"Abinashi Sabyasachi Sethy, Santosh Kumar Sethi, Jyotsna Sharma, Mangal Charan Murma, Subhabrata Parida","doi":"10.18231/j.pjms.2024.055","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.055","url":null,"abstract":"Retinopathy of rashness (ROP) is a critical reason for youth visual deficiency which gives a window period to screening & treatment prior to advancing to an extreme structure having poor visual result. Universally, no less than 50,000 kids are visually impaired because of ROP & an extra obscure number will be outwardly impeded or blind in one eye. To evaluate the administration of patients with Retinopathy of rashness & its result of the treatment applied in a tertiary level neonatal unit in the territory of Odisha. It is a clinic based unmistakable (cross-sectional) study, done from September 2019 to October 2021 done at SNCU of SCBMCH, Cuttack & SNCU, NICU of Sardar Vallabh bhai Patel Postgraduate Foundation of Pediatrics (SVPPGIP), Cuttack, Odisha who qualify the incorporation standards. During the review time of almost 2 years, 310 children were evaluated for ROP in which 117 were viewed as sure for ROP. The frequency of ROP in our review was 37.7%. ROP is viewed as related with the accompanying gamble factors in our review like low gestational age, low birth weight, oxygen treatment, RDS, paleness, blood bonding & septicemia, numerous births, hyperbilirubinemia with low birth weight & low gestational age & oxygen treatment being the main ones. Out of 31 cases treated with Avastin infusion, 26 gave indications of relapse till 2 months follow up & just 5 of them didn't give indications of relapse after infusion Bevacizumab. Those 5 children were treated with retinal removal by LASER photocoagulation following 10 days of beginning treatment, who gave indications of relapse till 2 months follow up. Legitimate screening & the executives of ROP can prompt counteraction of movement of infection to a more extreme stage with poor visual guess, consequently decreasing the weight of experience growing up visual deficiency. Intra vitreal hostile to VEGF infusion can be utilized as essential treatment for treatment justified ROP cases however more examination is expected to figure out the drawn out incidental effect profile of these medications.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"23 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.012
Jyotirmayee Mishra, Sobhagini Nayak, K. Mohapatra, H. Singh
Central nervous system (CNS) tumors comprise nearly 3% of all malignancies world-wide whereas in India it accounts for about 2%. In recent years there has been an increase in CNS tumors with new potential risk factors being observed. The aim of the present study is to highlight the histopathological spectrum of brain tumors in a single tertiary care centre in Western Odisha.This retrospective histopathological analysis of CNS tumors was conducted in the Department of Pathology, VIMSAR, Burla, Odisha, India from October 2016 to September 2020. In the span of 4 years, a total of 94 neurosurgical biopsies were studied. Histopathological examination of routinely processed tissue and hematoxylin and eosin (H&E) stained sections of corresponding cases were thoroughly examined. Immunohistochemistry (IHC) was done whenever required. Thereafter an approach was made to diagnose the cases, based on WHO classification system of 2016.A wide range of histopathological spectrum of CNS tumors was observed and was classified according to the WHO classification system of 2016. The primary CNS tumors were graded from Grade I to Grade IV. The most common CNS tumor in our study we found to be Astrocytic tumors (21 cases, 22.34%) followed by Schwannoma (19 cases, 20.21%) and meningiomas (18 cases, 19.14%). The incidence was more among males (59.51%) as compared to females (40.4%). This study provides an information regarding the prevalence of disease in Western Odisha. Use of modern imaging technique helps to a major extent in making a provisional.
{"title":"Retrospective study of CNS tumors in a tertiary care centre in Western Odisha - A 4 year study","authors":"Jyotirmayee Mishra, Sobhagini Nayak, K. Mohapatra, H. Singh","doi":"10.18231/j.pjms.2024.012","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.012","url":null,"abstract":"Central nervous system (CNS) tumors comprise nearly 3% of all malignancies world-wide whereas in India it accounts for about 2%. In recent years there has been an increase in CNS tumors with new potential risk factors being observed. The aim of the present study is to highlight the histopathological spectrum of brain tumors in a single tertiary care centre in Western Odisha.This retrospective histopathological analysis of CNS tumors was conducted in the Department of Pathology, VIMSAR, Burla, Odisha, India from October 2016 to September 2020. In the span of 4 years, a total of 94 neurosurgical biopsies were studied. Histopathological examination of routinely processed tissue and hematoxylin and eosin (H&E) stained sections of corresponding cases were thoroughly examined. Immunohistochemistry (IHC) was done whenever required. Thereafter an approach was made to diagnose the cases, based on WHO classification system of 2016.A wide range of histopathological spectrum of CNS tumors was observed and was classified according to the WHO classification system of 2016. The primary CNS tumors were graded from Grade I to Grade IV. The most common CNS tumor in our study we found to be Astrocytic tumors (21 cases, 22.34%) followed by Schwannoma (19 cases, 20.21%) and meningiomas (18 cases, 19.14%). The incidence was more among males (59.51%) as compared to females (40.4%). This study provides an information regarding the prevalence of disease in Western Odisha. Use of modern imaging technique helps to a major extent in making a provisional.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"10 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.019
Lohith K, Vinaya Manohara Gowda, Pradeep Kumar C N, Sriviruthi B S
The objectives of this study were to detect the rotator cuff injury using high-resolution ultrasonography in clinically suspected patients, compute MRI findings and compare the effectiveness of ultrasound and MRI diagnostically in such patients. 30 patients who were suspected to be suffering from rotator cuff injury were referred to the Department of Radiodiagnosis, Medical Trust Hospital, Kochi, Kerala. MRI and high-resolution ultrasonography were used to evaluate them after taking their written consent. The present study was carried out from November 2018 to October 2019. In partial thickness tears, the specificity of ultrasound was 87.5% and sensitivity was 72% whereas it was 83.3 % and 95.8% respectively for full-thickness tears. MRI was more sensitive than USG in evaluating the capsular and labral pathologies. MRI was the most sensitive and specific modality in the evaluation of shoulder pain. A specificity of 94% and a sensitivity of 92.3% was seen in relation to MRI in case of partial thickness tears; whereas in full thickness tears a specificity of 95.8% and a sensitivity of 100.0% were seen. In calcific tendinitis, picking bursal fluid and impingement, MRI was better than USG and also highly sensitive for labral tears. In the evaluation of shoulder pain, MRI is the most appropriate evaluation modality and in case of labral tears it is highly sensitive. When compared to USG, MRI is better in picking bursal fluid, impingement as well as calcific tendinitis and also in evaluating labral and capsular pathologies.
{"title":"Role of USG and MRI to detect the rotator cuff injury and to compare the efficacy of both","authors":"Lohith K, Vinaya Manohara Gowda, Pradeep Kumar C N, Sriviruthi B S","doi":"10.18231/j.pjms.2024.019","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.019","url":null,"abstract":"The objectives of this study were to detect the rotator cuff injury using high-resolution ultrasonography in clinically suspected patients, compute MRI findings and compare the effectiveness of ultrasound and MRI diagnostically in such patients. 30 patients who were suspected to be suffering from rotator cuff injury were referred to the Department of Radiodiagnosis, Medical Trust Hospital, Kochi, Kerala. MRI and high-resolution ultrasonography were used to evaluate them after taking their written consent. The present study was carried out from November 2018 to October 2019. In partial thickness tears, the specificity of ultrasound was 87.5% and sensitivity was 72% whereas it was 83.3 % and 95.8% respectively for full-thickness tears. MRI was more sensitive than USG in evaluating the capsular and labral pathologies. MRI was the most sensitive and specific modality in the evaluation of shoulder pain. A specificity of 94% and a sensitivity of 92.3% was seen in relation to MRI in case of partial thickness tears; whereas in full thickness tears a specificity of 95.8% and a sensitivity of 100.0% were seen. In calcific tendinitis, picking bursal fluid and impingement, MRI was better than USG and also highly sensitive for labral tears. In the evaluation of shoulder pain, MRI is the most appropriate evaluation modality and in case of labral tears it is highly sensitive. When compared to USG, MRI is better in picking bursal fluid, impingement as well as calcific tendinitis and also in evaluating labral and capsular pathologies.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"15 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute appendicitis is a very common abdominal emergency condition. The incidence varies from 5.7 to57 patient /lakh population per year in the world wide survey. It is frequent in both sexes, But highest in children & adolescences. Presentation of this condition is some time so confusing that it should be distinguished from other acute abdominal conditions in proper time and appropriate measures should be taken to treat the patients to avoid unwanted complications, this complication is probably more complicated in COVID-19 pandemic period. This study is designed to compare acute appendicitis cases in relation to clinical features, gradation of disease & post operative complications before COVID-19 (June 2019-March 2020) and during COVID-19 pandemic period (April 2020-October 2021). METHOD-Cases of the study were divided into 2-groups.Group-A (65 cases) in pre- pandemic period and Group-B (35 cases) in pandemic period. The study is based on the clinico-radiological features, laboratories investigations and gradation of disease. Gradation: Grade-I (probably appendicitis), Grade-II (definite appendicitis), Grade-III (perforation of appendices), Grade-IV (appendicular abscess), Grade-V (complicated appendicitis/ appendicular lump). Out of 100 enrolled cases 65 belongs to pre pandemic and 35 in pandemic period. It was found that increase in post-operative complications, were more in higher grade groups during pandemic periods. The COVID-19 pandemic has great impact on diagnosis, treatment and increased complications in post operative period of acute appendicitis, probably due to late presentation in emergency department. Pandemic directly or indirectly affect the outcome of a disease process and management.
{"title":"Retrospective analysis of acute appendicitis in COVID-19 pandemic – A clinical study of 100 cases","authors":"Debashisha Roy, Harekrishna Majhi, Manas Ranjan Mallick","doi":"10.18231/j.pjms.2024.026","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.026","url":null,"abstract":"Acute appendicitis is a very common abdominal emergency condition. The incidence varies from 5.7 to57 patient /lakh population per year in the world wide survey. It is frequent in both sexes, But highest in children & adolescences. Presentation of this condition is some time so confusing that it should be distinguished from other acute abdominal conditions in proper time and appropriate measures should be taken to treat the patients to avoid unwanted complications, this complication is probably more complicated in COVID-19 pandemic period. This study is designed to compare acute appendicitis cases in relation to clinical features, gradation of disease & post operative complications before COVID-19 (June 2019-March 2020) and during COVID-19 pandemic period (April 2020-October 2021). METHOD-Cases of the study were divided into 2-groups.Group-A (65 cases) in pre- pandemic period and Group-B (35 cases) in pandemic period. The study is based on the clinico-radiological features, laboratories investigations and gradation of disease. Gradation: Grade-I (probably appendicitis), Grade-II (definite appendicitis), Grade-III (perforation of appendices), Grade-IV (appendicular abscess), Grade-V (complicated appendicitis/ appendicular lump). Out of 100 enrolled cases 65 belongs to pre pandemic and 35 in pandemic period. It was found that increase in post-operative complications, were more in higher grade groups during pandemic periods. The COVID-19 pandemic has great impact on diagnosis, treatment and increased complications in post operative period of acute appendicitis, probably due to late presentation in emergency department. Pandemic directly or indirectly affect the outcome of a disease process and management.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"16 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.032
Rashmi Rekha Mahapatra, Rupa Das, Shree Kumar Chinmayananda Mishra, Gouranga Charan Prusty, Smita Rani Samal
Skin is the body’s largest and most complex organ, performing a wide range of functions. Environmental factors, genetics, cleanliness standards and social norms all influence the type of skin lesions that exist in different countries and regions. The skin lesions can vary from inflammatory to neoplastic. In clinically alike dermatoses, skin biopsy is used to provide significant information to the pathologist and dermatologist. The aim of the study is to identify and discuss the histopathology of different types of skin lesions, as well as their prevalence, age, sex distribution and location of lesions among hospital patients and compare the results with other relevant studies. The study was a retrospective observational study undertaken for the duration of three years in the Pathology Department of a tertiary health care center. Skin biopsy slides stained with hematoxylin and eosin were studied and classified after a detailed histopathological study under light microscope. 178 cases of skin lesions in total were evaluated having a 1.5:1 male to female ratio. Nonneoplastic lesions constituted 30.33% of skin lesions, while benign and malignant tumors constituted 55.05% and 14.6% of skin lesions respectively. In neoplastic lesions, keratinocytic tumors were the most common tumor type. The most common malignant tumor was squamous cell carcinoma, whereas epidermal inclusion cyst was the most prevalent benign tumor. The head and neck were the most prevalent sites for skin lesions. Most of the skin lesions can be accurately diagnosed by histopathological evaluation of biopsy of lesions in combination with clinical findings.
{"title":"Histopathological spectrum of skin lesions in a tertiary health care centre – A retrospective study","authors":"Rashmi Rekha Mahapatra, Rupa Das, Shree Kumar Chinmayananda Mishra, Gouranga Charan Prusty, Smita Rani Samal","doi":"10.18231/j.pjms.2024.032","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.032","url":null,"abstract":"Skin is the body’s largest and most complex organ, performing a wide range of functions. Environmental factors, genetics, cleanliness standards and social norms all influence the type of skin lesions that exist in different countries and regions. The skin lesions can vary from inflammatory to neoplastic. In clinically alike dermatoses, skin biopsy is used to provide significant information to the pathologist and dermatologist. The aim of the study is to identify and discuss the histopathology of different types of skin lesions, as well as their prevalence, age, sex distribution and location of lesions among hospital patients and compare the results with other relevant studies. The study was a retrospective observational study undertaken for the duration of three years in the Pathology Department of a tertiary health care center. Skin biopsy slides stained with hematoxylin and eosin were studied and classified after a detailed histopathological study under light microscope. 178 cases of skin lesions in total were evaluated having a 1.5:1 male to female ratio. Nonneoplastic lesions constituted 30.33% of skin lesions, while benign and malignant tumors constituted 55.05% and 14.6% of skin lesions respectively. In neoplastic lesions, keratinocytic tumors were the most common tumor type. The most common malignant tumor was squamous cell carcinoma, whereas epidermal inclusion cyst was the most prevalent benign tumor. The head and neck were the most prevalent sites for skin lesions. Most of the skin lesions can be accurately diagnosed by histopathological evaluation of biopsy of lesions in combination with clinical findings.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"19 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, we wanted to correlate the findings of TRUS and MRI with regard to the diagnosis and localization of carcinoma prostate and local staging of carcinoma prostate. Our study included 43 men, with age ranging from 49 to 76 years. They underwent TRUS, MRI and TRUS guided twelve core biopsies after being suspected with prostate cancer based on high PSA values (greater than 4.0 ng /ml) or abnormal DRE findings. This study was conducted from April 2018 -June 2019. Imaging findings were confirmed with histopathology. TRUS used for the detection of malignancy had sensitivity, specificity, PPV and NPV as 69.70%, 80 %, 92% and 44.44 % respectively. The values were 63.16%, 83.33%, 75.00%, and 74.07% for the sensitivity, specificity, PPV and NPV of TRUS respectively for the detection of ECE. rnFor the detection of malignancy, the sensitivity, specificity, PPV and NPV of MRI was 87.88%, 70%, 90.63% and 63.64% respectively and 85.71%, 89.66%, 80.00% and 92.86% for the sensitivity, specificity, PPV and NPV of MRI respectively for detection of SVI. For detection of extracapsular extension (ECE), MRI had sensitivity, specificity, PPV and NPV of 78.95%, 83.33%, 78.95% and 83.33% respectively. When compared to TRUS, MRI is more useful in the diagnosis and accurate staging of prostate cancer. MRI can improve the false-negative biopsies resulting due to the inability of TRUS in detection of abnormal areas.
{"title":"Role of transrectal ultrasound and MRI in the diagnosis and localisation of carcinoma prostate - A comparison of diagnostic efficacy of trus versus MRI","authors":"Sanjana Satish, Lohith K, Vinaya Manohara Gowda, Sriviruthi B, Prateek Parmeshwar Ugran, Vishal S Dharpur","doi":"10.18231/j.pjms.2024.034","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.034","url":null,"abstract":"In this study, we wanted to correlate the findings of TRUS and MRI with regard to the diagnosis and localization of carcinoma prostate and local staging of carcinoma prostate. Our study included 43 men, with age ranging from 49 to 76 years. They underwent TRUS, MRI and TRUS guided twelve core biopsies after being suspected with prostate cancer based on high PSA values (greater than 4.0 ng /ml) or abnormal DRE findings. This study was conducted from April 2018 -June 2019. Imaging findings were confirmed with histopathology. TRUS used for the detection of malignancy had sensitivity, specificity, PPV and NPV as 69.70%, 80 %, 92% and 44.44 % respectively. The values were 63.16%, 83.33%, 75.00%, and 74.07% for the sensitivity, specificity, PPV and NPV of TRUS respectively for the detection of ECE. rnFor the detection of malignancy, the sensitivity, specificity, PPV and NPV of MRI was 87.88%, 70%, 90.63% and 63.64% respectively and 85.71%, 89.66%, 80.00% and 92.86% for the sensitivity, specificity, PPV and NPV of MRI respectively for detection of SVI. For detection of extracapsular extension (ECE), MRI had sensitivity, specificity, PPV and NPV of 78.95%, 83.33%, 78.95% and 83.33% respectively. When compared to TRUS, MRI is more useful in the diagnosis and accurate staging of prostate cancer. MRI can improve the false-negative biopsies resulting due to the inability of TRUS in detection of abnormal areas.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"49 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.047
Archana Rajan, Deepa Narayanan
Blood Donation from healthy screened donors is a well-tolerated procedure. However a small percentage may experience adverse donor reactions. Donor haemovigilance aims at identifying and documenting these reactions for donor safety.: This prospective cross-sectional study conducted at the Department of Transfusion Medicine & Immunohaematology, Govt. Medical College, Kozhikode, Kerala for a one year study period from January 1st 2018 to December 31st 2018 included all adverse donor reactions and donor determinants in vasovagal reactions in allogenic whole blood donors. Donors were assessed as per the Standard Operating Procedure (S.O.P) based on national guidelines. 350ml collection bags were used. Vasovagal reactions were also graded as per the Blood Donation Reactions Inventory scale (B.D.R.I).: During the 1 year study period, 1.79% of 27,800 donors experienced adverse reactions. The most common symptoms were pre-syncopal 1.33% with syncope forming only 0.3% and local reactions 0.16%. Correlation with donor characteristics using Pearsons chi square test showed significance for female gender, first timers and lack of adequate sleep (<5 hrs). In our study there was no association with age (S.O.P guidelines) or food intake <4hrs.Our study reinforces the safety of blood donation with a very low prevalence of adverse reactions. Proper donor counseling and examination noting donor characteristics like adequate sleep, food intake and alleviation of fears and doubts of first timers can play a major role in further reducing the reaction rate and ensuring repeat donors, the need of the hour.
{"title":"Donor Haemovigilance: A South Indian experience","authors":"Archana Rajan, Deepa Narayanan","doi":"10.18231/j.pjms.2024.047","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.047","url":null,"abstract":"Blood Donation from healthy screened donors is a well-tolerated procedure. However a small percentage may experience adverse donor reactions. Donor haemovigilance aims at identifying and documenting these reactions for donor safety.: This prospective cross-sectional study conducted at the Department of Transfusion Medicine & Immunohaematology, Govt. Medical College, Kozhikode, Kerala for a one year study period from January 1st 2018 to December 31st 2018 included all adverse donor reactions and donor determinants in vasovagal reactions in allogenic whole blood donors. Donors were assessed as per the Standard Operating Procedure (S.O.P) based on national guidelines. 350ml collection bags were used. Vasovagal reactions were also graded as per the Blood Donation Reactions Inventory scale (B.D.R.I).: During the 1 year study period, 1.79% of 27,800 donors experienced adverse reactions. The most common symptoms were pre-syncopal 1.33% with syncope forming only 0.3% and local reactions 0.16%. Correlation with donor characteristics using Pearsons chi square test showed significance for female gender, first timers and lack of adequate sleep (<5 hrs). In our study there was no association with age (S.O.P guidelines) or food intake <4hrs.Our study reinforces the safety of blood donation with a very low prevalence of adverse reactions. Proper donor counseling and examination noting donor characteristics like adequate sleep, food intake and alleviation of fears and doubts of first timers can play a major role in further reducing the reaction rate and ensuring repeat donors, the need of the hour.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"38 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.024
Nikhil P V, J. Minal, H. Edupuganti, Archana Shetty, S. Sandeepa, Sandhyarani Kanna Mahadev, Nidha Gaffoor, A. Muralidhar, Bhargavi K Nagabhushan, N. Murali
A good pathology museum is intended to strengthen the intellectual material for the undergraduate students and visits to a pathology museum are an indispensable part of teaching pathology to medical students. The preservation of anatomy of pathological specimen is of utmost importance as the new successful current methods of therapy are changing the picture of diseases beyond recognition. We aim to elaborate the processes, difficulties and challenges faced in developing and setting up the pathology museum in a nascent medical college in a rural area. The new museum was set up in accordance with the guidelines provided by the National Medical Commission in addition to the guidelines of the state university. Literature search and discussions with other medical colleges all over the country also played an important role in the setting up of the museum. Our effort is to present our experience as hands on experience for setting up a pathology museum from a scratch for the pathologists, students and the technicians and also to increase the awareness to utilize the museum for innovative and interactive learning sessions for students by usage of QR coded specimens, museum catalogues, interactive E-kiosks and maintaining of log books.
一个好的病理博物馆旨在加强本科生的知识素材，参观病理博物馆是医科学生病理教学不可或缺的一部分。保存病理标本的解剖结构至关重要，因为目前新的成功治疗方法正在改变疾病的面貌，使其面目全非。我们旨在阐述在农村地区一所新兴医学院开发和建立病理博物馆的过程、困难和挑战。新博物馆是根据国家医学委员会提供的指导方针和州立大学的指导方针建立的。在建立博物馆的过程中，文献搜索和与全国其他医学院的讨论也发挥了重要作用。我们的工作是向病理学家、学生和技术人员介绍我们从零开始建立病理博物馆的亲身经历，并通过使用 QR 编码标本、博物馆目录、互动式 E-kiosks 和维护日志，提高学生利用博物馆进行创新和互动学习的意识。
{"title":"Establishing pathology museum in a new medical college: Processes and challenges","authors":"Nikhil P V, J. Minal, H. Edupuganti, Archana Shetty, S. Sandeepa, Sandhyarani Kanna Mahadev, Nidha Gaffoor, A. Muralidhar, Bhargavi K Nagabhushan, N. Murali","doi":"10.18231/j.pjms.2024.024","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.024","url":null,"abstract":"A good pathology museum is intended to strengthen the intellectual material for the undergraduate students and visits to a pathology museum are an indispensable part of teaching pathology to medical students. The preservation of anatomy of pathological specimen is of utmost importance as the new successful current methods of therapy are changing the picture of diseases beyond recognition. We aim to elaborate the processes, difficulties and challenges faced in developing and setting up the pathology museum in a nascent medical college in a rural area. The new museum was set up in accordance with the guidelines provided by the National Medical Commission in addition to the guidelines of the state university. Literature search and discussions with other medical colleges all over the country also played an important role in the setting up of the museum. Our effort is to present our experience as hands on experience for setting up a pathology museum from a scratch for the pathologists, students and the technicians and also to increase the awareness to utilize the museum for innovative and interactive learning sessions for students by usage of QR coded specimens, museum catalogues, interactive E-kiosks and maintaining of log books.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"17 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：