Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.056
Abhijit Halder, Sabyasachi Sarkar, Mainak Nath, Manidip Pal
Congenital Mullerian anomalies are associated with higher incidence of reproductive failure and adverse obstetrical outcomes. The new ESHRE classification is a precise way to describe a genital anomaly in simple way. Many genital tract anomalies lead to devastating life-threatening conditions but under-reported and poorly explained. This study aims at finding out those anomalies which more frequently lead to specific diseases needing emergency intervention to save life of the patient. This longitudinal observational study evaluates the diagnosis and treatment of 12 patients with congenital Mullerian abnormalities which led to life threatening emergency with case discussion and pictorial documentation. Among 12 women with uterine anomalies 4 abortions, 7 delivered preterm, 1 term delivery occurred. Majority of complications associated with U3 types (58.3%). Other types with complications are U4 (25%) and U2 (16.7%). Presenting features at emergency varied like mimicking ectopic, labour complications, ruptured corpus, placenta previa and accreta as well as iatrogenic perforation. Presence of congenital uterine anomalies have adverse effect on obstetrical outcome. Majority of complications are associated with U2, U3 & U4. Probably U1 doesn’t interfere with ongoing pregnancy and U5 fails to continue pregnancy. This knowledge warrants the need for a larger case control study to extrapolate these findings to the general population and also to recommend the need for universal Prenatal Screening for uterine anomalies so as to improve the obstetrical outcome in patients with uterine anomalies.
{"title":"Congenital Mullerian anomalies may lead to acute life threatening emergency in reproductive age group- An experience in a tertiary care centre in Eastern India","authors":"Abhijit Halder, Sabyasachi Sarkar, Mainak Nath, Manidip Pal","doi":"10.18231/j.pjms.2024.056","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.056","url":null,"abstract":"Congenital Mullerian anomalies are associated with higher incidence of reproductive failure and adverse obstetrical outcomes. The new ESHRE classification is a precise way to describe a genital anomaly in simple way. Many genital tract anomalies lead to devastating life-threatening conditions but under-reported and poorly explained. This study aims at finding out those anomalies which more frequently lead to specific diseases needing emergency intervention to save life of the patient. This longitudinal observational study evaluates the diagnosis and treatment of 12 patients with congenital Mullerian abnormalities which led to life threatening emergency with case discussion and pictorial documentation. Among 12 women with uterine anomalies 4 abortions, 7 delivered preterm, 1 term delivery occurred. Majority of complications associated with U3 types (58.3%). Other types with complications are U4 (25%) and U2 (16.7%). Presenting features at emergency varied like mimicking ectopic, labour complications, ruptured corpus, placenta previa and accreta as well as iatrogenic perforation. Presence of congenital uterine anomalies have adverse effect on obstetrical outcome. Majority of complications are associated with U2, U3 & U4. Probably U1 doesn’t interfere with ongoing pregnancy and U5 fails to continue pregnancy. This knowledge warrants the need for a larger case control study to extrapolate these findings to the general population and also to recommend the need for universal Prenatal Screening for uterine anomalies so as to improve the obstetrical outcome in patients with uterine anomalies.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"18 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.018
Tinaimeiru Golmei, Kodithyala Raghavendar Babu
Thyroid nodules are a frequent occurrence. With the widespread use of sensitive imaging methods, a growing number of thyroid nodules are being discovered by chance. High resolution ultrasonography (HRUSG) has emerged as the most appropriate imaging modality for the assessment of thyroid nodules.To Evaluate thyroid nodules by of high resolution ultrasonography (HRUSG) and its correlation with Fine needle aspiration cytology (FNAC). Prospective study done in the department of radiology at Maheshwara medical college and Hospital, Chitkul, near Isnapur, Patancheru, Sangareddy, Telangana for duration of 3 years. A total of 80 cases were studied.HRUSG was done in all cases and Fine Needle Aspiration cytology was done. Radiological and pathological correlation was done and Sensitivity, specificify PPV, NPV and accuracy were calculated. Females were predominant (62.5%) when compared to males (37.5%). Among 80 thyroid nodules , colloid nodule noted in 42.5% cases, Nodular goitre in 27.5%, Hashimotos thyroiditis and follicular adenoma in 12.5%cases and Malignancy in 5% cases HRUSG is a sensitive and specific imaging technique that has a high level of accuracy in the evaluation of thyroid nodules. Solid composition, hypoechogenicity, taller-than-wider form, ill-defined edges, and the presence of calcification are the most effective sonographic markers for predicting cancer.
{"title":"Evaluation of thyroid nodules by high resolution ultrasonography (HRUSG) and its cytological correlation in a teaching hospital","authors":"Tinaimeiru Golmei, Kodithyala Raghavendar Babu","doi":"10.18231/j.pjms.2024.018","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.018","url":null,"abstract":"Thyroid nodules are a frequent occurrence. With the widespread use of sensitive imaging methods, a growing number of thyroid nodules are being discovered by chance. High resolution ultrasonography (HRUSG) has emerged as the most appropriate imaging modality for the assessment of thyroid nodules.To Evaluate thyroid nodules by of high resolution ultrasonography (HRUSG) and its correlation with Fine needle aspiration cytology (FNAC). Prospective study done in the department of radiology at Maheshwara medical college and Hospital, Chitkul, near Isnapur, Patancheru, Sangareddy, Telangana for duration of 3 years. A total of 80 cases were studied.HRUSG was done in all cases and Fine Needle Aspiration cytology was done. Radiological and pathological correlation was done and Sensitivity, specificify PPV, NPV and accuracy were calculated. Females were predominant (62.5%) when compared to males (37.5%). Among 80 thyroid nodules , colloid nodule noted in 42.5% cases, Nodular goitre in 27.5%, Hashimotos thyroiditis and follicular adenoma in 12.5%cases and Malignancy in 5% cases HRUSG is a sensitive and specific imaging technique that has a high level of accuracy in the evaluation of thyroid nodules. Solid composition, hypoechogenicity, taller-than-wider form, ill-defined edges, and the presence of calcification are the most effective sonographic markers for predicting cancer.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"5 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.049
Nidhi Y Mangrola, RG Mahajan, Kshama D. Gajera, Kuntalkumar H. Patel
Adolescent obesity is becoming more prevalent due to changing lifestyles, and it has negative effects like a higher incidence of non-communicable diseases. Identification of risk factors leading to the rapid rise in adolescent obesity is a crucial first step in preventing and controlling it. Therefore, this study was carried out in Rajkot. The primary objective was to find the prevalence of obesity among the school going adolescents aged 14-19 years and to identify the determinants associated with obesity. A cross-sectional study among the adolescents studying in school was carried out by using multistage sampling method. A predesigned questionnaire with personal and family history and details of dietary habits and physical activity was filled by the participants. Anthropometric measurements of the participants including height, weight, waist and hip circumference were taken. Out of total 1120 participants, 25.8% were underweight, 11.1% were overweight and 6.9% were obese. Overweight and obesity was significantly associated with the occupation of participant’s father and mother, lack of physical activity, more screen time, non-vegetarian diet and daily consumption of carbonated drinks and chocolates. (p<0.001). The determinants like physical activity and dietary habits were found to be associated with overweight and obesity. Modifying one's lifestyle can be very helpful in preventing adolescent obesity as well as developing healthy routines for later life.
{"title":"Prevalence and determinants of overweight and obesity among adolescent school children of Rajkot city, India","authors":"Nidhi Y Mangrola, RG Mahajan, Kshama D. Gajera, Kuntalkumar H. Patel","doi":"10.18231/j.pjms.2024.049","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.049","url":null,"abstract":"Adolescent obesity is becoming more prevalent due to changing lifestyles, and it has negative effects like a higher incidence of non-communicable diseases. Identification of risk factors leading to the rapid rise in adolescent obesity is a crucial first step in preventing and controlling it. Therefore, this study was carried out in Rajkot. The primary objective was to find the prevalence of obesity among the school going adolescents aged 14-19 years and to identify the determinants associated with obesity. A cross-sectional study among the adolescents studying in school was carried out by using multistage sampling method. A predesigned questionnaire with personal and family history and details of dietary habits and physical activity was filled by the participants. Anthropometric measurements of the participants including height, weight, waist and hip circumference were taken. Out of total 1120 participants, 25.8% were underweight, 11.1% were overweight and 6.9% were obese. Overweight and obesity was significantly associated with the occupation of participant’s father and mother, lack of physical activity, more screen time, non-vegetarian diet and daily consumption of carbonated drinks and chocolates. (p<0.001). The determinants like physical activity and dietary habits were found to be associated with overweight and obesity. Modifying one's lifestyle can be very helpful in preventing adolescent obesity as well as developing healthy routines for later life.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A fibrocystic breast disease group of benign breast diseases that consists of fibrocystic breast disease, breast cyst, breast abscess, duct ectasia, cyclic and non-cyclic mastalgia, Gynaecomastia and Mondor's disease. Abnormal hormonal balance and cellular interactions mediated growth factors leading to ductal and cellular hyperplasia is the main pathophysiological cause of the disease. This prospective observational study was conducted on 100 SGT medical college and hospital patients from January 2021 to august 2022 to assess the detailed clinicopathological study of patients with fibrocystic disease breast diagnosed clinically with relevant investigations. In our study, we found that fibroadenoma is the maximum among all Fibrocystic breast diseases, i.e. 34%, with the majority between 11-30 years. It rises in the 2 decade of life and peaks in the 4 decade. Non-cyclic mastalgia constituted 29% of the total cases, with most patients lying in the age group of 31-50 years, where mastalgia was the presenting complaint in most cases. Inflammatory breast diseases formed 4% of the total, with the main presenting symptoms being mastalgia, fever and nipple discharge. Again, it mainly included patients from the age group of 31-50 years. Gynaecomastia and breast abscess were diagnosed in 3 cases, with all lumping on the right side of the breast.Our study attempted to derivate the spectrum of breast diseases in different age groups among patients reporting to SGT medical college and hospital, SGT University, Gurugram, Haryana. Apart from the incidence of various fibrocystic diseases, various other facts were recorded. Benign breast lesions were recorded to comprise the bulk of the patients presenting with breast disorders and were maximum in the reproductive age group. Breast sclerosing adenosis should be identified by excluding the malignancy. Most Fibrocystic breast diseases have been managed conservatively.
{"title":"Clinical and pathological study of patients with fibrocystic disease of breast in tertiary care hospital of Gurugram, Haryana","authors":"Sapna Goel, Bhumika Singhal, Anil Kumar, Kanwar Singh, Tanay Arora, Aditi Narayan","doi":"10.18231/j.pjms.2024.005","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.005","url":null,"abstract":"A fibrocystic breast disease group of benign breast diseases that consists of fibrocystic breast disease, breast cyst, breast abscess, duct ectasia, cyclic and non-cyclic mastalgia, Gynaecomastia and Mondor's disease. Abnormal hormonal balance and cellular interactions mediated growth factors leading to ductal and cellular hyperplasia is the main pathophysiological cause of the disease. This prospective observational study was conducted on 100 SGT medical college and hospital patients from January 2021 to august 2022 to assess the detailed clinicopathological study of patients with fibrocystic disease breast diagnosed clinically with relevant investigations. In our study, we found that fibroadenoma is the maximum among all Fibrocystic breast diseases, i.e. 34%, with the majority between 11-30 years. It rises in the 2 decade of life and peaks in the 4 decade. Non-cyclic mastalgia constituted 29% of the total cases, with most patients lying in the age group of 31-50 years, where mastalgia was the presenting complaint in most cases. Inflammatory breast diseases formed 4% of the total, with the main presenting symptoms being mastalgia, fever and nipple discharge. Again, it mainly included patients from the age group of 31-50 years. Gynaecomastia and breast abscess were diagnosed in 3 cases, with all lumping on the right side of the breast.Our study attempted to derivate the spectrum of breast diseases in different age groups among patients reporting to SGT medical college and hospital, SGT University, Gurugram, Haryana. Apart from the incidence of various fibrocystic diseases, various other facts were recorded. Benign breast lesions were recorded to comprise the bulk of the patients presenting with breast disorders and were maximum in the reproductive age group. Breast sclerosing adenosis should be identified by excluding the malignancy. Most Fibrocystic breast diseases have been managed conservatively.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"15 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.009
Manisha B Sinha, R. K. Ukey, H. Sinha
: Meckel’s diverticulum (MD) develops from persistent omphalomesenteric duct and is an uncommon finding in females. Our aim is to report the incidence of finding of MD in cadavers and to study its gross and histological feature. : The observational study was conducted in 60 cadavers over a period of nine years. In the present study a meckel’s diverticulum was detected in sixty years old female cadaver. : The diverticulum was 63 cm proximal to ileocecal junction. It was 6 cm in length and 3.5cm in width and its tip free from any connections. Histologically, it showed four layers of ileum and patchy areas of coagulative necrosis in the mucosa.: These uneventful Meckel’s diverticulum findings of meckel’s diverticulum should be reported from time to time in particular population which may be beneficial for the surgeons and radiologists.
{"title":"The incidence, gross and histological features of Meckel’s diverticulum: A cadaveric study","authors":"Manisha B Sinha, R. K. Ukey, H. Sinha","doi":"10.18231/j.pjms.2024.009","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.009","url":null,"abstract":": Meckel’s diverticulum (MD) develops from persistent omphalomesenteric duct and is an uncommon finding in females. Our aim is to report the incidence of finding of MD in cadavers and to study its gross and histological feature. : The observational study was conducted in 60 cadavers over a period of nine years. In the present study a meckel’s diverticulum was detected in sixty years old female cadaver. : The diverticulum was 63 cm proximal to ileocecal junction. It was 6 cm in length and 3.5cm in width and its tip free from any connections. Histologically, it showed four layers of ileum and patchy areas of coagulative necrosis in the mucosa.: These uneventful Meckel’s diverticulum findings of meckel’s diverticulum should be reported from time to time in particular population which may be beneficial for the surgeons and radiologists.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"8 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.014
A. Bhardwaj, Manpreet Singh, Deepti Arora, Hardik Pahuja, Shalika
There is a high psychological morbidity that is reported in undergraduate medical students. This can range from stress, anxiety, interpersonal problems, suicide to psychiatric disorders. The objective of our study was to assess the prevalence of depression, anxiety and stress amongst the first year undergraduate students in a medical college. A cross sectional study was undertaken after approval from institutional ethical committee which included the 150 undergraduate medical students of 1 year. A semi structured performa which included socio demographic profile was used along with Depression, Anxiety and Stress Scale (DASS 42) for assessment. Most of the participated students were females (57.5%). All of the students (100%) were residing in hostel and were unmarried. Stress was reported by majority (86.7%) of the students with few reporting low social support (7.3%). Single responses to causes of stress were in majority (74.6%). Prevalence of depression, anxiety and stress was 56%, 68.7% and 61.3% respectively. A considerable number of undergraduate medical students are affected and suffer from anxiety, stress and depression. There is an urgent need to address the issue and give more attention towards mental health of students.
{"title":"Prevalence of stress, anxiety and depression amongst 1st year medical students in a medical college","authors":"A. Bhardwaj, Manpreet Singh, Deepti Arora, Hardik Pahuja, Shalika","doi":"10.18231/j.pjms.2024.014","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.014","url":null,"abstract":"There is a high psychological morbidity that is reported in undergraduate medical students. This can range from stress, anxiety, interpersonal problems, suicide to psychiatric disorders. The objective of our study was to assess the prevalence of depression, anxiety and stress amongst the first year undergraduate students in a medical college. A cross sectional study was undertaken after approval from institutional ethical committee which included the 150 undergraduate medical students of 1 year. A semi structured performa which included socio demographic profile was used along with Depression, Anxiety and Stress Scale (DASS 42) for assessment. Most of the participated students were females (57.5%). All of the students (100%) were residing in hostel and were unmarried. Stress was reported by majority (86.7%) of the students with few reporting low social support (7.3%). Single responses to causes of stress were in majority (74.6%). Prevalence of depression, anxiety and stress was 56%, 68.7% and 61.3% respectively. A considerable number of undergraduate medical students are affected and suffer from anxiety, stress and depression. There is an urgent need to address the issue and give more attention towards mental health of students.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"15 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.020
Chinmayee Barthakur, Julie Sarmah, N. Saharia
The neonatal period carries the highest risk of death per day compared to any other period during childhood. Of all newborn deaths three fourths result from three preventable and treatable conditions– complications due to prematurity, intrapartum related deaths (including birth asphyxia) and neonatal infections. The study was to describe the morbidity pattern with outcome, based on clinical diagnosis and relevant biochemical parameters amongst neonates admitted in NICU in the tertiary care hospital. A retrospective case record analysis of all the NICU admissions between January 2021 to March 2021 was done based on both electronic and hard data. The neonates with complete records of clinical presentation, relevant biochemical investigations were included in the study. Out of 624 neonates admitted in NICU during the study period, 622 were included in the final analysis. The proportion of fullterm and preterm among inborns (77.6% &18.8%) and outborns (76.2% & 21.8%) were similar, but the proportion of low-birth-weight babies in outborns was higher than in the inborns. The overall discharge rate was 85.5%. It was higher for inborn neonates as compared to outborn neonates (88.7% vs 79%). The death rate was higher in outborns than in inborns. The highest no of NICU admission was due to asphyxia related conditions followed by neonatal jaundice in both genders and in all inborn and outborn neonates. Out of total admissions in NICU, 72(11.6%) was due to infections causing neonatal sepsis, meningitis and acquired pneumonia. While neonatal jaundice has a lower mortality rate, preventable conditions like birth asphyxia and infections remain major concerns for neonatal morbidity and mortality in this region. The study emphasizes the need for strengthened antenatal care, improved infection control, and increased access to trained neonatologists to ensure better outcomes for newborns.
{"title":"Morbidity pattern based on clinico-biochemical profile of neonates admitted in NICU of a tertiary care hospital in the mid north bank region of Assam","authors":"Chinmayee Barthakur, Julie Sarmah, N. Saharia","doi":"10.18231/j.pjms.2024.020","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.020","url":null,"abstract":"The neonatal period carries the highest risk of death per day compared to any other period during childhood. Of all newborn deaths three fourths result from three preventable and treatable conditions– complications due to prematurity, intrapartum related deaths (including birth asphyxia) and neonatal infections. The study was to describe the morbidity pattern with outcome, based on clinical diagnosis and relevant biochemical parameters amongst neonates admitted in NICU in the tertiary care hospital. A retrospective case record analysis of all the NICU admissions between January 2021 to March 2021 was done based on both electronic and hard data. The neonates with complete records of clinical presentation, relevant biochemical investigations were included in the study. Out of 624 neonates admitted in NICU during the study period, 622 were included in the final analysis. The proportion of fullterm and preterm among inborns (77.6% &18.8%) and outborns (76.2% & 21.8%) were similar, but the proportion of low-birth-weight babies in outborns was higher than in the inborns. The overall discharge rate was 85.5%. It was higher for inborn neonates as compared to outborn neonates (88.7% vs 79%). The death rate was higher in outborns than in inborns. The highest no of NICU admission was due to asphyxia related conditions followed by neonatal jaundice in both genders and in all inborn and outborn neonates. Out of total admissions in NICU, 72(11.6%) was due to infections causing neonatal sepsis, meningitis and acquired pneumonia. While neonatal jaundice has a lower mortality rate, preventable conditions like birth asphyxia and infections remain major concerns for neonatal morbidity and mortality in this region. The study emphasizes the need for strengthened antenatal care, improved infection control, and increased access to trained neonatologists to ensure better outcomes for newborns.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"76 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.pjms.2024.013
Darbha S Murty, Prasanthi Kolli, P. Jyothi, Muralidhar Metta, Anumula Kavitha, T. Lokeshu
The present study was aimed at the molecular detection of HBV infection among patients with chronic liver disease (CLD) and to study the mutation spectrum S-gene region in the occult HBV strains. An observational study conducted on 200 clinically diagnosed CLD cases enrolled from the Gastroenterology unit. Two hundred serum samples were screened with Fibroscan and for HBsAg, HBCT and estimated liver enzymes. Samples positive for either HBsAg or Anti HBc total were further evaluated for other HBV markers and presence of HBV DNA. The S region was amplified in occult CHB cases and sequenced. 70.5% (141) of the patients with CLD were suffering with Chronic Hepatitis B virus (CHB). The HBV DNA was detected in 19.14% patients. Four cases were in occult phase. Two samples of them could be amplified. The isolates belong to the genotype A, and revealed certain mutations leading to novel amino acids. Mutations in the S gene sequences of HBV virus from the Occult HBV infection (OBI) patients would lead to immune escape or cause occult infection. In the Genotype A at two positions, amino acids that are likely to cause occult infection are observed apart from mutations at certain positions leading to novel amino acids.
本研究旨在对慢性肝病（CLD）患者中的 HBV 感染进行分子检测，并研究隐性 HBV 株系中 S 基因区的变异谱。该研究是一项观察性研究，对象是 200 名从消化内科登记的临床诊断为慢性肝病的病例。对 200 份血清样本进行了纤维扫描和 HBsAg、HBCT 及估计肝酶筛查。对 HBsAg 或抗 HBc 阳性的样本进一步评估其他 HBV 标记和 HBV DNA 的存在。对隐性 CHB 病例中的 S 区进行扩增和测序。70.5%（141 例）的 CLD 患者患有慢性乙型肝炎病毒（CHB）。19.14%的患者检测到 HBV DNA。四例处于隐匿期。其中两个样本可以扩增。分离出的病毒属于基因 A 型，并发现了某些导致新型氨基酸的突变。隐性 HBV 感染（OBI）患者 HBV 病毒 S 基因序列的突变会导致免疫逃逸或引起隐性感染。在基因型 A 的两个位置上，除了某些位置上的突变导致新的氨基酸外，还观察到可能导致隐性感染的氨基酸。
{"title":"Cross sectional study on the molecular detection of hepatitis b virus in patients with chronic liver disease in Guntur, India revealed mutations in genotype a of occult HBV","authors":"Darbha S Murty, Prasanthi Kolli, P. Jyothi, Muralidhar Metta, Anumula Kavitha, T. Lokeshu","doi":"10.18231/j.pjms.2024.013","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.013","url":null,"abstract":"The present study was aimed at the molecular detection of HBV infection among patients with chronic liver disease (CLD) and to study the mutation spectrum S-gene region in the occult HBV strains. An observational study conducted on 200 clinically diagnosed CLD cases enrolled from the Gastroenterology unit. Two hundred serum samples were screened with Fibroscan and for HBsAg, HBCT and estimated liver enzymes. Samples positive for either HBsAg or Anti HBc total were further evaluated for other HBV markers and presence of HBV DNA. The S region was amplified in occult CHB cases and sequenced. 70.5% (141) of the patients with CLD were suffering with Chronic Hepatitis B virus (CHB). The HBV DNA was detected in 19.14% patients. Four cases were in occult phase. Two samples of them could be amplified. The isolates belong to the genotype A, and revealed certain mutations leading to novel amino acids. Mutations in the S gene sequences of HBV virus from the Occult HBV infection (OBI) patients would lead to immune escape or cause occult infection. In the Genotype A at two positions, amino acids that are likely to cause occult infection are observed apart from mutations at certain positions leading to novel amino acids.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"18 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vesicular mole is defined as the premalignant form of gestational trophoblasticneoplasia. I5-20% of complete moles and <5% of partial moles will develop into Gestational Trophoblastic Neoplasia. It is of clinical and epidemiological interest because of its potential for significant consequences on women's health. The study aims to determine the incidence, outcomes and complications of pregnancy with vesicular mole at SKNMC hospital, Pune. It was a retrospective study. Approval for the study was obtained from institutional ethical committee. Data was collected from OPD, OT register and Indoor patient record file from August 2015 to August 2020. Proformas were filled. All the collected data was compiled in a master chart, analysed and outcomes of different variables under study have been expressed in the form of mean, frequencies, percentages and charts. The incidence of molar pregnancy was 0.17% or 1 in 561 deliveries. Vesicular mole occurred more in the age group 16 to 25 years, was lowest in age group 31-35yrs. Vesicular mole was most common in nulliparous women. The mean gestational age of the patients at presentation was 9.4 week. Hemorrhage after suction and evacuation was seen in 26% cases needing intra and post-operative blood transfusion. 6% of patients developed thyrotoxicosis. During follow up invasive mole was diagnosed in 2 cases (6%). The case fatality rate is 2.9% in our study. 1 patient (3%) developed choriocarcinoma and died within 6months after hysterectomy and chemotherapy. The incidence of 1 in 561 deliveries which is higher than non-Asian countries 1/752 but lower than other Asian countries 1/387. The routine first trimester ultrasonography helps in early detection of asymptomatic women. If not followed up regularly it can be life threatening.
{"title":"Study of vesicular mole and its outcomes","authors":"Shilpa Chaudhari, Aparna Sasane, Kishor Hol, Dyuti Navadia","doi":"10.18231/j.pjms.2024.029","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.029","url":null,"abstract":"Vesicular mole is defined as the premalignant form of gestational trophoblasticneoplasia. I5-20% of complete moles and <5% of partial moles will develop into Gestational Trophoblastic Neoplasia. It is of clinical and epidemiological interest because of its potential for significant consequences on women's health. The study aims to determine the incidence, outcomes and complications of pregnancy with vesicular mole at SKNMC hospital, Pune. It was a retrospective study. Approval for the study was obtained from institutional ethical committee. Data was collected from OPD, OT register and Indoor patient record file from August 2015 to August 2020. Proformas were filled. All the collected data was compiled in a master chart, analysed and outcomes of different variables under study have been expressed in the form of mean, frequencies, percentages and charts. The incidence of molar pregnancy was 0.17% or 1 in 561 deliveries. Vesicular mole occurred more in the age group 16 to 25 years, was lowest in age group 31-35yrs. Vesicular mole was most common in nulliparous women. The mean gestational age of the patients at presentation was 9.4 week. Hemorrhage after suction and evacuation was seen in 26% cases needing intra and post-operative blood transfusion. 6% of patients developed thyrotoxicosis. During follow up invasive mole was diagnosed in 2 cases (6%). The case fatality rate is 2.9% in our study. 1 patient (3%) developed choriocarcinoma and died within 6months after hysterectomy and chemotherapy. The incidence of 1 in 561 deliveries which is higher than non-Asian countries 1/752 but lower than other Asian countries 1/387. The routine first trimester ultrasonography helps in early detection of asymptomatic women. If not followed up regularly it can be life threatening.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"11 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A precancerous lesion is often defined as morphologically altered tissue during which the occurrence of carcinoma is more likely than its normal counterpart. Head and neck cancers include cancers of the mouth and therefore the larynx, also as some rarer cancers like cancer of the sinuses, salivary glands, nose, and tympanic cavity. Head and neck cancers are often described as consistent with the sort of cell they begin with. A biomarker could be defined and interpreted as biological molecule which is mostly found in body fluids, blood or even tissues that indicates abnormalities of our body. Here we've taken three biomarkers (LDH, CRP, IL-8) to gauge their level rise in pre-malignant and malignant lesions which are present in our head and neck. Patients attending ENT OPD with primary symptoms indicating premalignant and malignant lesions in the region of head and neck had been included for the analytical study. Complete ENT examination followed by biopsy of the suspicious lesion and blood sample collection was done. A complete of 30 patients were included in each group of premalignant and malignant lesions. No mean serum rise of serum LDH was noted in premalignant and malignant lesions. A mean serum rise of serum CRP was noted in premalignant lesions but was not noted in malignant lesions. However, both premalignant and malignant lesions noted a mean serum rise of IL-8. From a future perspective serum evaluation of biomarkers can become a replacement diagnostic modality for the early evaluation of premalignant lesions and malignant lesions and for monitoring the prognosis of an equivalent.
{"title":"Correlation of serum biomarker (LDH, CRP, IL-8) levels in pre-malignant and malignant lesions of head and neck","authors":"S. Faiz, Harsha Singh, Mariyam Parveen, Kriti Bhatt, Abhijeet Singh, Samiullah","doi":"10.18231/j.pjms.2024.022","DOIUrl":"https://doi.org/10.18231/j.pjms.2024.022","url":null,"abstract":"A precancerous lesion is often defined as morphologically altered tissue during which the occurrence of carcinoma is more likely than its normal counterpart. Head and neck cancers include cancers of the mouth and therefore the larynx, also as some rarer cancers like cancer of the sinuses, salivary glands, nose, and tympanic cavity. Head and neck cancers are often described as consistent with the sort of cell they begin with. A biomarker could be defined and interpreted as biological molecule which is mostly found in body fluids, blood or even tissues that indicates abnormalities of our body. Here we've taken three biomarkers (LDH, CRP, IL-8) to gauge their level rise in pre-malignant and malignant lesions which are present in our head and neck. Patients attending ENT OPD with primary symptoms indicating premalignant and malignant lesions in the region of head and neck had been included for the analytical study. Complete ENT examination followed by biopsy of the suspicious lesion and blood sample collection was done. A complete of 30 patients were included in each group of premalignant and malignant lesions. No mean serum rise of serum LDH was noted in premalignant and malignant lesions. A mean serum rise of serum CRP was noted in premalignant lesions but was not noted in malignant lesions. However, both premalignant and malignant lesions noted a mean serum rise of IL-8. From a future perspective serum evaluation of biomarkers can become a replacement diagnostic modality for the early evaluation of premalignant lesions and malignant lesions and for monitoring the prognosis of an equivalent.","PeriodicalId":30643,"journal":{"name":"PANACEA JOURNAL OF MEDICAL SCIENCES","volume":"16 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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