Abstrak Resusitasi dengan pengendalian kerusakanmenggambarkan suatu pendekatan ke perawatan awal pada pasien dengan cedera berat. Tujuan pendekatan ini untuk menjaga pasien tetap stabil dengan menghindari intervensi dan kondisi yang berisiko kepada keadaan perburukan dengan mengendalikan trias kematian, yaitu hipotermia, koagulopati, dan asidosis. Merupakan hal yang penting bahwa konsep dan kepraktisan pendekatan ini dipahami oleh semua yang terlibat dalam manajemen awal pasien trauma. Pendekatan ini dimulai dengan pemberian produk darah sejak awal, penghentian perdarahan dan pengembalian volume darah yang bertujuan untuk mengembalikan stabilitas fisiologis dengan cepat. Resusitasi dengan pengendalian kerusakan memilikibeberapa tambahan pendekatan dari bidang farmakologis dan laboratorium untuk meningkatkan perawatan pasien yang mengalami perdarahan. Pendekatan ini termasuk trombelastografi sebagai ukuran rinci kaskade pembekuan, asam traneksamat sebagai antifibrinolitik. Kata kunci : hipotermia, koagulopati, asidosis, perdarahan masif Damage Control Resuscitation in Intensive Care Unit Abstract Damage control resuscitation (DCR) describes an approach to the early care of very seriously injured patients. The aim is to keep the patient alive whilst avoiding interventions and situations that risk worsening their situation by driving the lethal triad of hypothermia, coagulopathy and acidosis.It is critical that the concepts and practicalities of this approach are understood by all those involved in the early management of trauma patients. Damage control resuscitation forms part of an overall approach to patient care rather than a specific intervention and has evolved from damage control surgery. It is characterised by early blood product administration, haemorrhage arrest and restoration of blood volume aiming to rapidly restore physiologic stability. The infusion of large volumes of crystalloid is no longer appropriate, instead the aim is to replace lost blood and avoid dilution and coagulopathy. In specific situations, permissive hypotension may also be of benefit, particularly in patients with severe haemorrhage from an arterial source. Damage control resuscitation has been augmented by both pharmacologic and laboratory adjuncts to improve the care of the hemorrhaging patient. These include thrombelastography as a detailed measure of the clotting cascade, tranexamic acid as an antifibrinolytic. Keywords: hypothermia, coagulopathy, acidosis, massive bleeding
{"title":"Resusitasi Pengendalian Kerusakan Di Unit Perawatan Intensif","authors":"Dhanu Pitra Arianto, Nurita Dian Kestriani","doi":"10.33541/mk.v36i2.3096","DOIUrl":"https://doi.org/10.33541/mk.v36i2.3096","url":null,"abstract":"Abstrak \u0000Resusitasi dengan pengendalian kerusakanmenggambarkan suatu pendekatan ke perawatan awal pada pasien dengan cedera berat. Tujuan pendekatan ini untuk menjaga pasien tetap stabil dengan menghindari intervensi dan kondisi yang berisiko kepada keadaan perburukan dengan mengendalikan trias kematian, yaitu hipotermia, koagulopati, dan asidosis. Merupakan hal yang penting bahwa konsep dan kepraktisan pendekatan ini dipahami oleh semua yang terlibat dalam manajemen awal pasien trauma. Pendekatan ini dimulai dengan pemberian produk darah sejak awal, penghentian perdarahan dan pengembalian volume darah yang bertujuan untuk mengembalikan stabilitas fisiologis dengan cepat. Resusitasi dengan pengendalian kerusakan memilikibeberapa tambahan pendekatan dari bidang farmakologis dan laboratorium untuk meningkatkan perawatan pasien yang mengalami perdarahan. Pendekatan ini termasuk trombelastografi sebagai ukuran rinci kaskade pembekuan, asam traneksamat sebagai antifibrinolitik. \u0000 \u0000Kata kunci : hipotermia, koagulopati, asidosis, perdarahan masif \u0000 \u0000 \u0000Damage Control Resuscitation in Intensive Care Unit \u0000 \u0000Abstract \u0000Damage control resuscitation (DCR) describes an approach to the early care of very seriously injured patients. The aim is to keep the patient alive whilst avoiding interventions and situations that risk worsening their situation by driving the lethal triad of hypothermia, coagulopathy and acidosis.It is critical that the concepts and practicalities of this approach are understood by all those involved in the early management of trauma patients. Damage control resuscitation forms part of an overall approach to patient care rather than a specific intervention and has evolved from damage control surgery. It is characterised by early blood product administration, haemorrhage arrest and restoration of blood volume aiming to rapidly restore physiologic stability. The infusion of large volumes of crystalloid is no longer appropriate, instead the aim is to replace lost blood and avoid dilution and coagulopathy. In specific situations, permissive hypotension may also be of benefit, particularly in patients with severe haemorrhage from an arterial source. Damage control resuscitation has been augmented by both pharmacologic and laboratory adjuncts to improve the care of the hemorrhaging patient. These include thrombelastography as a detailed measure of the clotting cascade, tranexamic acid as an antifibrinolytic. \u0000 \u0000Keywords: hypothermia, coagulopathy, acidosis, massive bleeding","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126729896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irfan Y. Mijaya, Mendy Thensya Sahetapy, Dewiyana A. Kusmana
Abstrak Spondilitis tuberkulosis (TB) atau Pott’s disease adalah infeksi tulang belakang yang disebabkan Mycobacterium tuberculosis akibat TB ekstrapulmoner. Penyakit ini tergantung berbagai faktor seperti usia, status gizi, dan penyakit penyerta. Penelitian deskriptif ini dilakuakn untuk mengetahui Profil pasien spondilitis tuberkulosis di Rumah Sakit Pusat Angkatan Darat (RSPAD) Gatot Soebroto. Data diperoleh dari rekam medis sebanyak 75 sampel. Penelitian ini menunjukkan jenis kelamin laki – laki (50,7%), kelompok usia 21 – 29 tahun (29,3%), dan status gizi normal (33,3%) merupakan kelompok yang terbanyak terkena spondilitis tuberkulosis (TB). Jenis pekerjaan terbanyak merupakan ibu rumah tangga (28,0%). Sebanyak 69 pasien (92%) tidak memiliki riwayat merokok dan semua pasien tidak memiliki riwayat mengonsumsi alkohol. Hanya 1 orang pasien spondilitis TB yang memiliki hasil basil tahan asam (BTA) positif. Sebanyak 41 orang (54,7%) pasien spondilitis TB didiagnosis melalui Magnetic Resonance Imaging/ Computerized Tomographic Scan (MRI/CT SCAN) dengan lesi spondilitis TB terbanyak terdapat pada torakal. Kemampuan MRI mendiagnosis lebih baik dibandingkan PCR dan BTA. Kata kunci: Status Gizi, Torakal, Basil Tahan Asam The Profile of Tuberculosis Spondylitis patients (Pott's Disease) at Rumah Sakit Pusat Angkatan Darat Gatot Soebroto Abstract Tuberculous spondylitis (TB) or Pott's disease is a spinal infection caused by Mycobacterium tuberculosis due to extrapulmonary TB. This disease depends on various factors such as age, nutritional status, and comorbidities. This descriptive study was conducted to determine the profile of tuberculosis spondylitis patients at the Gatot Soebroto Central Army Hospital (RSPAD). Data obtained from medical records of 75 samples. This study showed that male gender (50.7%), age group 21-29 years (29.3%), and normal nutritional status (33.3%) were the groups most affected by tuberculosis spondylitis (TB). Most types of work were housewives (28.0%). A total of 69 patients (92%) had no history of smoking and all patients had no history of consuming alcohol. Only 1 TB spondylitis patient had positive acid-resistant bacilli (AFB). A total of 41 people (54.7%) TB spondylitis patients were diagnosed through Magnetic Resonance Imaging / Computerized Tomographic Scan (MRI / CT SCAN) with the most TB spondylitis lesions found in the thoracic. The ability of MRI to diagnose is better than PCR and BTA. Key words: Nutritional Status, Thoracic, Acid Resistant Basil
{"title":"Profil Pasien Spondilitis Tuberkulosis (Pott’s Disease) di Rumah Sakit Pusat Angkatan Darat Gatot Soebroto","authors":"Irfan Y. Mijaya, Mendy Thensya Sahetapy, Dewiyana A. Kusmana","doi":"10.33541/mk.v36i2.3092","DOIUrl":"https://doi.org/10.33541/mk.v36i2.3092","url":null,"abstract":"Abstrak \u0000Spondilitis tuberkulosis (TB) atau Pott’s disease adalah infeksi tulang belakang yang disebabkan Mycobacterium tuberculosis akibat TB ekstrapulmoner. Penyakit ini tergantung berbagai faktor seperti usia, status gizi, dan penyakit penyerta. Penelitian deskriptif ini dilakuakn untuk mengetahui Profil pasien spondilitis tuberkulosis di Rumah Sakit Pusat Angkatan Darat (RSPAD) Gatot Soebroto. Data diperoleh dari rekam medis sebanyak 75 sampel. Penelitian ini menunjukkan jenis kelamin laki – laki (50,7%), kelompok usia 21 – 29 tahun (29,3%), dan status gizi normal (33,3%) merupakan kelompok yang terbanyak terkena spondilitis tuberkulosis (TB). Jenis pekerjaan terbanyak merupakan ibu rumah tangga (28,0%). Sebanyak 69 pasien (92%) tidak memiliki riwayat merokok dan semua pasien tidak memiliki riwayat mengonsumsi alkohol. Hanya 1 orang pasien spondilitis TB yang memiliki hasil basil tahan asam (BTA) positif. Sebanyak 41 orang (54,7%) pasien spondilitis TB didiagnosis melalui Magnetic Resonance Imaging/ Computerized Tomographic Scan (MRI/CT SCAN) dengan lesi spondilitis TB terbanyak terdapat pada torakal. Kemampuan MRI mendiagnosis lebih baik dibandingkan PCR dan BTA. \u0000 \u0000Kata kunci: Status Gizi, Torakal, Basil Tahan Asam \u0000 \u0000The Profile of Tuberculosis Spondylitis patients (Pott's Disease) at Rumah Sakit Pusat Angkatan Darat Gatot Soebroto \u0000 \u0000Abstract \u0000Tuberculous spondylitis (TB) or Pott's disease is a spinal infection caused by Mycobacterium tuberculosis due to extrapulmonary TB. This disease depends on various factors such as age, nutritional status, and comorbidities. This descriptive study was conducted to determine the profile of tuberculosis spondylitis patients at the Gatot Soebroto Central Army Hospital (RSPAD). Data obtained from medical records of 75 samples. This study showed that male gender (50.7%), age group 21-29 years (29.3%), and normal nutritional status (33.3%) were the groups most affected by tuberculosis spondylitis (TB). Most types of work were housewives (28.0%). A total of 69 patients (92%) had no history of smoking and all patients had no history of consuming alcohol. Only 1 TB spondylitis patient had positive acid-resistant bacilli (AFB). A total of 41 people (54.7%) TB spondylitis patients were diagnosed through Magnetic Resonance Imaging / Computerized Tomographic Scan (MRI / CT SCAN) with the most TB spondylitis lesions found in the thoracic. The ability of MRI to diagnose is better than PCR and BTA. \u0000 \u0000Key words: Nutritional Status, Thoracic, Acid Resistant Basil","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116068423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-28DOI: 10.33541/mkvol34iss2pp60
Widia A. A. Cahyaningtyas, Sudung Nainggolan, T. P. Simanjuntak
Abstrak Keputihan (leukorea, flour albus, vaginal discharge) adalah sekret berlebihan dari vagina selain darah haid, dan tidak disebabkan neoplasma atau penyakit sistemik. Keputihan merupakan masalah kesehatan reproduksi dialami hampir 75% perempuan didunia, paling tidak sekali selama hidupnya. Kurangnya pengetahuan, sikap, dan praktik dalam perawatan vagina diyakini berpengaruh terhadap kejadian keputihan patologis tersebut. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap, dan praktik personal hygiene organ genital eksterna terhadap kejadian keputihan patologis pada mahasiswi Fakultas Kedokteran Universitas Kristen Indonesia. Penelitian ini menggunakan desain penelitian analitik korelasional pada 98 mahasiswi. Terdapathubungan yang bermakna (p= 0,000) dan korelasi positif antara tingkat pengetahuan, sikap dan praktik personal hygiene dengan kejadian keputihan patologis. Kata Kunci : keputihan, pengetahuan, sikap, praktik, personal hygiene. Relationship Between Knowledge, Attitudes and Personal Practices of External Genitalia Hygiene Against Pathological Leucorrhoea Abstract Vaginal discharge (leukorrhea, flour albus, vaginal discharge) is excessive discharge from the vagina other than menstrual blood, and is not caused by neoplasms or systemic disease. Leucorrhoea is a reproductive health problem that affects nearly 75% of women in the world, at least once in their lifetime. Lack of knowledge, attitude, and practice in vaginal care is believed to have an effect on the incidence of pathological vaginal discharge. This study aims to determine the relationship between knowledge, attitudes, and personal hygiene practices of external genital organs on the incidence of pathological vaginal discharge in students of the Faculty of Medicine, Christian University of Indonesia. This study used a correlational analytical research design on 98 female students of the Faculty of Medicine, Christian University of Indonesia. It was found a significant relationship (p = 0.000) and a positive correlation between the level of knowledge, attitudes and personal hygiene practices with the incidence of pathological vaginal discharge. Keywords: leucorrhoea, knowledge, attitude, practice, personal hygiene.
{"title":"Hubungan Antara Pengetahuan, Sikap dan Praktik Personal Hygiene Organ Genitalia Eksterna Terhadap Kejadian Keputihan Patologis","authors":"Widia A. A. Cahyaningtyas, Sudung Nainggolan, T. P. Simanjuntak","doi":"10.33541/mkvol34iss2pp60","DOIUrl":"https://doi.org/10.33541/mkvol34iss2pp60","url":null,"abstract":"Abstrak Keputihan (leukorea, flour albus, vaginal discharge) adalah sekret berlebihan dari vagina selain darah haid, dan tidak disebabkan neoplasma atau penyakit sistemik. Keputihan merupakan masalah kesehatan reproduksi dialami hampir 75% perempuan didunia, paling tidak sekali selama hidupnya. Kurangnya pengetahuan, sikap, dan praktik dalam perawatan vagina diyakini berpengaruh terhadap kejadian keputihan patologis tersebut. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap, dan praktik personal hygiene organ genital eksterna terhadap kejadian keputihan patologis pada mahasiswi Fakultas Kedokteran Universitas Kristen Indonesia. Penelitian ini menggunakan desain penelitian analitik korelasional pada 98 mahasiswi. Terdapathubungan yang bermakna (p= 0,000) dan korelasi positif antara tingkat pengetahuan, sikap dan praktik personal hygiene dengan kejadian keputihan patologis. Kata Kunci : keputihan, pengetahuan, sikap, praktik, personal hygiene. Relationship Between Knowledge, Attitudes and Personal Practices of External Genitalia Hygiene Against Pathological Leucorrhoea Abstract Vaginal discharge (leukorrhea, flour albus, vaginal discharge) is excessive discharge from the vagina other than menstrual blood, and is not caused by neoplasms or systemic disease. Leucorrhoea is a reproductive health problem that affects nearly 75% of women in the world, at least once in their lifetime. Lack of knowledge, attitude, and practice in vaginal care is believed to have an effect on the incidence of pathological vaginal discharge. This study aims to determine the relationship between knowledge, attitudes, and personal hygiene practices of external genital organs on the incidence of pathological vaginal discharge in students of the Faculty of Medicine, Christian University of Indonesia. This study used a correlational analytical research design on 98 female students of the Faculty of Medicine, Christian University of Indonesia. It was found a significant relationship (p = 0.000) and a positive correlation between the level of knowledge, attitudes and personal hygiene practices with the incidence of pathological vaginal discharge. Keywords: leucorrhoea, knowledge, attitude, practice, personal hygiene.","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115336344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronny -, Nadia L. Destifani, Edho Yuwono, F. E. Siagian, Retno Wahyuningsih
Abstrak Blastocystis hominis merupakan emerging disease yang terdistribusi luas di dunia, dengan prevalensi 10% di negara maju hingga 60% di negara berkembang. Perannya sebagai mikroorganisme patogen masih kontroversial. Diduga angka kejadian B. hominis lebih banyak didapatkan pada curah hujan yang rendah dan daerah tropis/ sub-tropis. Penelitian dilakukan untuk mengetahui prevalensi, profil B. hominis di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia, serta hubungan antara angka kejadian infeksi B. hominis dengan curah hujan dan kelembaban pada musim penghujan dan kemarau. Penelitian potong lintang deksriptif berdasarkan data pemeriksaan feses di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia selama 20 tahun sejak Januari 2000 sampai dengan Desember 2019. Sampel feses diperiksa dari sediaan basah dengan pewarnaan eosin dan lugol, dan hasilnya dilaporkan dengan sistem skoring semi kuantitatif. Data curah hujan dan kelembaban didapatkan dari Badan Meteorologi Klimatologi dan Geofisika Stasiun Meteorologi Kemayoran Jakarta.Didapatkan 3270 sampel, dengan hasil sampel positif B. hominissebanyak 440 sampel (14%), Prevalensi pada perempuan lebih tinggi dibandingkan laki-laki dan terbanyak pada kelompok usia 21-60 tahun (67,4%). Persentase tertinggi ditemukan pada feses dengan konsistensi cair. Tidak ditemukan hubungan antara prevalensi infeksi B. hominis dengan curah hujan (P=0,285) dan kelembaban (P=0,204). Kata kunci: prevalensi, konsistensi, curah hujan, kelembaban, musim Profile and Prevalence of Blastocystis hominis at Parasitology Laboratory, Medical Faculty Universitas Kristen Indonesia Abstract Blastocystis hominis is an emerging disease that is widely distributed in the world, with a prevalence of 10% in developed countries to 60% in developing countries. Its role as a pathogen is still controversial. It is suspected that the incidence of B. hominis is mostly found in low rainfall and tropical/ sub-tropical areas. The study was conducted to determine the prevalence and profile of B. hominis in the Laboratory of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia.and the relationship between incidence of B. hominisinfection with rainfall and humidity in the rainy and dry seasons.This descriptive cross-sectional study was based on fecal examination data at the FK UKI Parasitology Laboratory for 20 years. from January 2000 to December 2019. Stool examination was carried out by making eosin and lugol wet preparations to examine intestinal protozoa, and the results were reported using a semi-quantitative scoring system.Rainfall and humidity data are obtained from the Meteorology, Climatology and Geophysics Agency of the Stasiun MeteorologiKemayoran, Jakarta. As many as3270 samples were obtained, feses with B. hominis positive results was 440 samples (14%). Based on gender, 53.1% of B. hominisinfected were women and most patients were found in the age range from 21
人类囊胚是世界上分布广泛的新疾病，发达国家10%的发病率高达发展中国家的60%。他作为病原体的作用仍有争议。被认为，在低降水和亚热带地区发现的创世纪数字B. hominis更为普遍。研究的目的是确定印尼一所大学医学院寄生虫学实验室的普及率、B.人缘学感染病例与季风和旱季降雨和湿度之间的关系。根据2000年1月至2019年12月间在印尼基督教大学医学院(university of christian college of medical school)养生学实验室对粪便分析数据进行研究，为期20年。粪便样本由具有eosin和lugol染色的湿剂型检测，结果与弹簧定量悬挂系统报告。来自雅加达Kemayoran气象站的气象学和地球物理气象中心的降雨和湿度数据。获得了3270个样本，阳性样本结果为440个(14%)，女性比男性流行程度高，21-60岁年龄段(67.4%)。在液体一致性的粪便中发现的比例最高。雷氏B. hominis感染普及率(P= 0.285)和湿度(P= 0.204)之间没有联系。关键词:人口普及率、一致性、降水量、湿度、湿度、季节性条件和温室气体的流行程度，印尼基督教大学抽象的温室气体分布在世界各地，发展中国家占人口比例的10%，发展中国家占60%。它像病原体一样静止控制。据推测，B.人类最早在rainfall和热带地区发现的证据是间接的。这项研究是负责确定寄生虫学、医学、印尼基督教大学实验室的优先权和概况的。以及在雨水和干燥季节里与rainfall和humidity之间的关系。这篇关于性别关系研究的描述是基于20年寄生虫研究。从2000年1月到2019年12月。排泄物的排泄物是由生产、分解原生动物的准备而引起的，结果报告使用了一个半定量计量系统。Rainfall和humidity数据来自雅加达气象局、气候学和地理机构。许多阿斯3270个样本被结节，以B.正体结果为440个样本(14%)。基于性别，53.1%的女性和大多数患者从21岁到60岁(67.4%)的年龄被发现。最崇高的追求是在水土中发现的。B. hominis感染rainfall (p= 0.285)和humidity (p= 0.204)之间没有明显的意义。特殊，有弹性，rainfall, humidity，赛季
{"title":"Profil dan Prevalensi Blastocystis hominis di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia","authors":"Ronny -, Nadia L. Destifani, Edho Yuwono, F. E. Siagian, Retno Wahyuningsih","doi":"10.33541/mk.v36i2.3093","DOIUrl":"https://doi.org/10.33541/mk.v36i2.3093","url":null,"abstract":"Abstrak \u0000Blastocystis hominis merupakan emerging disease yang terdistribusi luas di dunia, dengan prevalensi 10% di negara maju hingga 60% di negara berkembang. Perannya sebagai mikroorganisme patogen masih kontroversial. Diduga angka kejadian B. hominis lebih banyak didapatkan pada curah hujan yang rendah dan daerah tropis/ sub-tropis. Penelitian dilakukan untuk mengetahui prevalensi, profil B. hominis di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia, serta hubungan antara angka kejadian infeksi B. hominis dengan curah hujan dan kelembaban pada musim penghujan dan kemarau. Penelitian potong lintang deksriptif berdasarkan data pemeriksaan feses di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia selama 20 tahun sejak Januari 2000 sampai dengan Desember 2019. Sampel feses diperiksa dari sediaan basah dengan pewarnaan eosin dan lugol, dan hasilnya dilaporkan dengan sistem skoring semi kuantitatif. Data curah hujan dan kelembaban didapatkan dari Badan Meteorologi Klimatologi dan Geofisika Stasiun Meteorologi Kemayoran Jakarta.Didapatkan 3270 sampel, dengan hasil sampel positif B. hominissebanyak 440 sampel (14%), Prevalensi pada perempuan lebih tinggi dibandingkan laki-laki dan terbanyak pada kelompok usia 21-60 tahun (67,4%). Persentase tertinggi ditemukan pada feses dengan konsistensi cair. Tidak ditemukan hubungan antara prevalensi infeksi B. hominis dengan curah hujan (P=0,285) dan kelembaban (P=0,204). \u0000 \u0000Kata kunci: prevalensi, konsistensi, curah hujan, kelembaban, musim \u0000 \u0000Profile and Prevalence of Blastocystis hominis at Parasitology Laboratory, Medical Faculty Universitas Kristen Indonesia \u0000 \u0000Abstract \u0000Blastocystis hominis is an emerging disease that is widely distributed in the world, with a prevalence of 10% in developed countries to 60% in developing countries. Its role as a pathogen is still controversial. It is suspected that the incidence of B. hominis is mostly found in low rainfall and tropical/ sub-tropical areas. The study was conducted to determine the prevalence and profile of B. hominis in the Laboratory of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia.and the relationship between incidence of B. hominisinfection with rainfall and humidity in the rainy and dry seasons.This descriptive cross-sectional study was based on fecal examination data at the FK UKI Parasitology Laboratory for 20 years. from January 2000 to December 2019. Stool examination was carried out by making eosin and lugol wet preparations to examine intestinal protozoa, and the results were reported using a semi-quantitative scoring system.Rainfall and humidity data are obtained from the Meteorology, Climatology and Geophysics Agency of the Stasiun MeteorologiKemayoran, Jakarta. As many as3270 samples were obtained, feses with B. hominis positive results was 440 samples (14%). Based on gender, 53.1% of B. hominisinfected were women and most patients were found in the age range from 21 ","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129525582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tio Dora Parhusip, Bambang Suprayogi Resi Utomo, Lina Marlina, Fransiscus Harp Poluan, Jurita Falorin, Adli Nurfachri, Dameria Pohan
Abstrak Otitis media supuratif kronis (OMSK) merupakan inflamasi dari telinga tengah dan rongga mastoid kronis, ditandai dengan perforasi membran timpani serta cairan yang keluar dari telinga secara persisten. Gangguan pendengaran dan kecacatan umumnya disebabkan oleh OMSK. Komplikasi otitis media supuratif kronis lainnya dapat menyebabkan infeksi intrakranial yang fatal dan mastoiditis akut, terutama di Negara-negara berkembang. Penatalaksanaan yang efektif tergantung pada pengetahuan mengenai mikroorganisme penyebab dan sensitivitas mikroba. Penelitian ini bertujuan untuk mengetahui pola bakteri penyebab otitis media supuratif kronis di Rumah Sakit Umum Universitas Kristen Indonesia Tahun 2019. Metode penelitian yang digunakan adalah deskriptif dengan pendekatan secara clinical series yang dilakukan dari bulan Agustus 2019 sampai November 2019 di Poliklinik THT-KL RSU UKI dan Laboratorium Mikrobiologi FK UKI. Hasil dari 17 sampel menunjukkan bahwa Staphylococcus aureus merupakan bakteri terbanyak yang ditemukan pada penderita OMSK yaitu 6 (35,3%), diikuti Pseudomonas aerugenosa 5 (29,4%), Staphylococcus epidermidis 2 (11,8%), Klebsiella spp. 2 (11,8%), Proteus spp. 1 (5,9%), Escherichia coli 1 (5,9%). Kata kunci :otitis media supuratif kronis, pola bakteri. Abstract Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle ear and mastoid cavity, followed with recurrent ear discharges or otorrhoea through a tympanic perforation. Hearing impairment and disability are generally caused by CSOM. Other complications of chronic suppurative otitis media can lead to fatal intracranial infections and acute mastoiditis, especially in developing countries. Effectivity of the disease management depends on the knowledge of causative microorganisms and their antimicrobial sensitivity. The purpose of this study is to identify the bacterial pattern that cause chronic suppurative otitis media in Christian University of Indonesia General Hospital in 2019. This study is using the descriptive method with a clinical series approach, this study was carried out from August 2019 to November 2019 at the polyclinic of ENT-HNS RSU UKI and Microbiology Laboratory FK UKI. The results of 17 samples showed Staphylococcus aureus was the most bacteria found in CSOM patient 6 samples (35,3%), followed Pseudomonas aerugenosa 5 (29,4%), Staphylococcus epidermidis 2 (11,8%), Klebsiella spp. 2 (11,8%), Proteus spp. 1 (5,9%), Escherichia coli 1 (5,9%). Keywords: chronic suppurative otitis media, bacterial pattern
{"title":"Bakteri Penyebab Otitis Media Supuratif Kronis di Rumah Sakit Umum Universitas Kristen Indonesia","authors":"Tio Dora Parhusip, Bambang Suprayogi Resi Utomo, Lina Marlina, Fransiscus Harp Poluan, Jurita Falorin, Adli Nurfachri, Dameria Pohan","doi":"10.33541/mk.v36i1.2988","DOIUrl":"https://doi.org/10.33541/mk.v36i1.2988","url":null,"abstract":"Abstrak \u0000Otitis media supuratif kronis (OMSK) merupakan inflamasi dari telinga tengah dan rongga mastoid kronis, ditandai dengan perforasi membran timpani serta cairan yang keluar dari telinga secara persisten. Gangguan pendengaran dan kecacatan umumnya disebabkan oleh OMSK. Komplikasi otitis media supuratif kronis lainnya dapat menyebabkan infeksi intrakranial yang fatal dan mastoiditis akut, terutama di Negara-negara berkembang. Penatalaksanaan yang efektif tergantung pada pengetahuan mengenai mikroorganisme penyebab dan sensitivitas mikroba. Penelitian ini bertujuan untuk mengetahui pola bakteri penyebab otitis media supuratif kronis di Rumah Sakit Umum Universitas Kristen Indonesia Tahun 2019. Metode penelitian yang digunakan adalah deskriptif dengan pendekatan secara clinical series yang dilakukan dari bulan Agustus 2019 sampai November 2019 di Poliklinik THT-KL RSU UKI dan Laboratorium Mikrobiologi FK UKI. Hasil dari 17 sampel menunjukkan bahwa Staphylococcus aureus merupakan bakteri terbanyak yang ditemukan pada penderita OMSK yaitu 6 (35,3%), diikuti Pseudomonas aerugenosa 5 (29,4%), Staphylococcus epidermidis 2 (11,8%), Klebsiella spp. 2 (11,8%), Proteus spp. 1 (5,9%), Escherichia coli 1 (5,9%). \u0000 Kata kunci :otitis media supuratif kronis, pola bakteri. \u0000Abstract \u0000Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle ear and mastoid cavity, followed with recurrent ear discharges or otorrhoea through a tympanic perforation. Hearing impairment and disability are generally caused by CSOM. Other complications of chronic suppurative otitis media can lead to fatal intracranial infections and acute mastoiditis, especially in developing countries. Effectivity of the disease management depends on the knowledge of causative microorganisms and their antimicrobial sensitivity. The purpose of this study is to identify the bacterial pattern that cause chronic suppurative otitis media in Christian University of Indonesia General Hospital in 2019. This study is using the descriptive method with a clinical series approach, this study was carried out from August 2019 to November 2019 at the polyclinic of ENT-HNS RSU UKI and Microbiology Laboratory FK UKI. The results of 17 samples showed Staphylococcus aureus was the most bacteria found in CSOM patient 6 samples (35,3%), followed Pseudomonas aerugenosa 5 (29,4%), Staphylococcus epidermidis 2 (11,8%), Klebsiella spp. 2 (11,8%), Proteus spp. 1 (5,9%), Escherichia coli 1 (5,9%). \u0000Keywords: chronic suppurative otitis media, bacterial pattern","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125388193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstrak Candida sp. dan Cryptococcus sp. merupakan jamur oportunistik yang dapat menyebabkan penyakit pada manusia dan dapat berakibat fatal jika tidak ditangani dengan cepat dan tepat. Saat ini terdapat permasalahan yaitu resistensi antijamur dan jenis terapi terhadap jamur yang terbatas. Terdapatnya bahan alam yang melimpah di Indonesia menjadi suatu potensi untuk mengembangkan obat anti jamur baru yang memiliki efektivitas tinggi, efek samping yang minimal, dan murah. Salah satu bahan alam yang belum tereksplorasi untuk antijamur adalah biji pepaya varietas bangkok. Biji pepaya selama ini lebih banyak menjadi limbah organik. Oleh karena hal tersebut, tujuan dari penelitian ini adalah untuk menguji aktivitas antijamur dari ekstrak biji pepaya bangkok (Carica papaya L.). Jamur yang digunakan pada penelitian ini adalah Candida albicans dan Cryptococcus neoformans. Metode yang digunakan adalah perhitungan zona hambat pada sumur di cawan petri. Hasil penelitian menunjukkan bahwa tidak terdapat zona hambat pada media yang terdapat C. albicans dan C. neoformans. Dapat disimpulkan, ekstrak biji papaya tidak memiliki aktivitas antijamur terhadap kedua jamur tersebut. Kata kunci: Pepaya bangkok, Antijamur, Bahan alam Abstract Candida sp. and Cryptococcus sp. are opportunistic fungi that can be fatal disease in humans if not treated properly. However, resistance of antifungal drugs have been emerged, therefore limit their benefit for therapy. Many natural products in Indonesia have potential to be established for new antifungal drugs that have high effectiveness, minimal side effects, and inexpensive. Papaya bangkok seed has not been explored for its antifungal activity. This seed become more organic waste. The aim of this study was to test antifungal activity of various papaya bangkok seed extract concentrations. We measured the inhibiton zone of papaya extract to Candida albicans and Cryptococcus neoformans. Result showed no inhibition zone for each seed extract concentrations. Papaya bangkok seed extract has not antifungal activity. Keywords: Papaya bangkok, antifungal, natural product
{"title":"Aktivitas Antijamur Ekstrak Biji Pepaya (Carica Papaya L.) Varietas Bangkok","authors":"F. E. Siagian, Dena Carolina Sabono, M. Alfarabi","doi":"10.33541/mk.v36i1.2987","DOIUrl":"https://doi.org/10.33541/mk.v36i1.2987","url":null,"abstract":"Abstrak \u0000Candida sp. dan Cryptococcus sp. merupakan jamur oportunistik yang dapat menyebabkan penyakit pada manusia dan dapat berakibat fatal jika tidak ditangani dengan cepat dan tepat. Saat ini terdapat permasalahan yaitu resistensi antijamur dan jenis terapi terhadap jamur yang terbatas. Terdapatnya bahan alam yang melimpah di Indonesia menjadi suatu potensi untuk mengembangkan obat anti jamur baru yang memiliki efektivitas tinggi, efek samping yang minimal, dan murah. Salah satu bahan alam yang belum tereksplorasi untuk antijamur adalah biji pepaya varietas bangkok. Biji pepaya selama ini lebih banyak menjadi limbah organik. Oleh karena hal tersebut, tujuan dari penelitian ini adalah untuk menguji aktivitas antijamur dari ekstrak biji pepaya bangkok (Carica papaya L.). Jamur yang digunakan pada penelitian ini adalah Candida albicans dan Cryptococcus neoformans. Metode yang digunakan adalah perhitungan zona hambat pada sumur di cawan petri. Hasil penelitian menunjukkan bahwa tidak terdapat zona hambat pada media yang terdapat C. albicans dan C. neoformans. Dapat disimpulkan, ekstrak biji papaya tidak memiliki aktivitas antijamur terhadap kedua jamur tersebut. \u0000Kata kunci: Pepaya bangkok, Antijamur, Bahan alam \u0000Abstract \u0000Candida sp. and Cryptococcus sp. are opportunistic fungi that can be fatal disease in humans if not treated properly. However, resistance of antifungal drugs have been emerged, therefore limit their benefit for therapy. Many natural products in Indonesia have potential to be established for new antifungal drugs that have high effectiveness, minimal side effects, and inexpensive. Papaya bangkok seed has not been explored for its antifungal activity. This seed become more organic waste. The aim of this study was to test antifungal activity of various papaya bangkok seed extract concentrations. We measured the inhibiton zone of papaya extract to Candida albicans and Cryptococcus neoformans. Result showed no inhibition zone for each seed extract concentrations. Papaya bangkok seed extract has not antifungal activity. \u0000Keywords: Papaya bangkok, antifungal, natural product","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121405507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lili Indrawati, Purwantyastuti, M. Abdullah, I. Surono
Annona muricata leaves contains phytochemical substances, such as alkaloids, tannins, flavonoids, saponins, anthraquinones and cardiac glycosides, ellagic acid, triterpenoids, β- sitosterol. Polyphenols are considered to be potential in providing health benefits via modulation the gut microecology. Alteration of the gut microbiota composition can be achieved by consuming of flavonol-rich foods that exerting prebiotic-like effects. Short chain fatty acids (SCFA) that are produced from highly fermentable fibers is considered to be protective against colon cancer. Subjects were assigned consecutively into two group: ethanolic extract of A. muricata, and maltose as placebo. Ssupplementation was conducted for 8 weeks in a capsule. SCFA level assessment was conducted at baseline and the end of the study period. Gas liquid chromatography was used to determine concentration of butyrate. Fiber intake was measured using food record. Concentrations of fecal butyrate levelwas not significantly different between Fraction of A. muricata water extract that is soluble in ethanol (FAMSE) and placebo (p=0.854). Level of others SCFA were also not significantly different. The low fiberintakeisconsistent with the finding on fecal butyrate concentration, as shown by no significant increase in both groups. There is no statistically significant effect of supplementation with ethanol-soluble fraction of A muricata leaves water extract on fecal SCFA level of colo rectal cancer (CRC) patients, andin line with fiber intake below recommended daily allowance throughout the study period. Keywords: phytochemical substances, fiber intake, gut microbiota Abstrak Daun sirsak (Annona muricata) mengandung senyawa fitokimia seperti alkaloid, tanin, flavonoid, saponin, antraquinon, cardiac glycosides, ellagic acid, triterpenoid, dan β-sitosterol. Polifenol memiliki potensi yang baik dalam kesehatan dengan cara memodulasi mikro-ekologi usus. Komposisi microbiota usus dapat berubah dengan cara mengkonsumsi makanan yang banyak mengandung flavonol yang memberikan efek seperti prebiotik. Asam lemak rantai pendek yang dihasilkan dari fermentasi tinggi serat dapat mencegah terjadinya kanker kolon. Subyek penelitian dibagi menjadi dua kelompok secara berurutan, yaitu ekstrak etanol Annonamuricata dan maltosa sebagai plasebo. Pemberian suplemen dilakukan selama 8 minggu dalam bentuk kapsul. Pengukuran kadar asam lemak rantai pendek dilakukan pada awal dan akhir masa studi ini. Pengukuran kadar asam butirat dilakukan dengan kromatografi gas. Asupan serat diukur berdasarkan catatan makanan. Konsentrasi kadar asam butirat pada feses tidak berbeda signifikan dengan fraksi ekstrak air Annona muricata yang larut di dalam etanol dan plasebo (p=0.854). Kadar dari asam lemak rantai pendek lainnya juga tidak berbeda nyata. Asupan serat yang rendah sejalan dengan pengukuran kadar asam butirat di feses yang menunjukkan tidak ada peningkatan secara signifikan pada kedua kelompok. Tidak terdapat pengar
番荔枝叶含有生物碱、单宁、黄酮类、皂苷、蒽醌类、心苷类、鞣花酸、三萜、β-谷甾醇等植物化学物质。多酚被认为可能通过调节肠道微生态提供健康益处。肠道菌群组成的改变可以通过食用富含黄酮醇的食物来实现，这些食物可以发挥类似益生元的作用。由高度可发酵的纤维产生的短链脂肪酸(SCFA)被认为对结肠癌有保护作用。受试者被连续分为两组:木槿花乙醇提取物和麦芽糖作为安慰剂。在胶囊中补充8周。在基线和研究期结束时进行SCFA水平评估。采用气相液相色谱法测定丁酸盐的浓度。采用食物记录法测定纤维摄入量。牛蒡水提物与安慰剂的粪便丁酸盐浓度差异无统计学意义(p=0.854)。其他SCFA水平也无显著差异。低纤维摄入量与粪便丁酸盐浓度的发现是一致的，两组都没有显著增加。补充田中叶水提取物的乙醇溶性部分对结直肠癌(CRC)患者粪便中短链脂肪酸水平的影响没有统计学意义，并且在整个研究期间纤维摄入量低于推荐的每日允取量。关键词:植物化学物质，纤维摄入，肠道微生物群摘要:牡丹牡丹生物碱，单宁，黄酮类化合物，皂素，蒽醌，心脏苷，鞣花酸，三萜，丹β-谷甾醇。多酚对微生态系统的调节作用。Komposisi的微生物群是:dapat berubah, dengan, mengkonsumsi, makanan yang, mengandung，黄酮醇yang, memberkan efek seperti。Asam lemak rantai pendek yang dihasilkan dari fermenti(印度)，印度，印度，印度，印度。Subyek penelitian dibagi menjadi dua kelompok secara berurutan, yitu ekstrak etol annamuricata和maltosa sebagai plasebo。Pemberian补品dilakukan selama 8 minggu dalam bentuk kapsul。企鹅kadar asam lemak rantai pendek dilakukan padar awal danakhir masa studi ini。企鹅kadar asam butirat dilakukan dengan kromatogram gas。Asupan serat diukur berdasarkan catatan makanan。康森特拉斯·卡达尔(Konsentrasi kadar)的研究结果表明，康森特拉尔(konsentraskada)的研究结果与康森特拉尔(anona muricata)的研究结果有显著性差异(p=0.854)。Kadar dari asam lemak rantai pendek lainnya juga tidak berbeda nyata。当一只企鹅在这里的时候，它就像一只企鹅，在这里的时候，它就像一只企鹅。有些terdapat pengaruh杨signifikan suplementasi dengan fraksi larut etanol ekstrak空气daun番荔枝属muricata篇konsentrasi asam laksa rantai pendek菲斯达里语pasien kanker kolon丹·哈尔itu sejalan dengan asupan serat dibawah rekomendasi harian杨dilakukan selama玛莎以某ini。卡塔昆奇:嗜氧菌，嗜氧菌，嗜氧菌群
{"title":"Effects of Annona muricate Extract on Short Chain Fatty Acid Level of Colorectal Cancer Patients","authors":"Lili Indrawati, Purwantyastuti, M. Abdullah, I. Surono","doi":"10.33541/mk.v36i1.2985","DOIUrl":"https://doi.org/10.33541/mk.v36i1.2985","url":null,"abstract":"Annona muricata leaves contains phytochemical substances, such as alkaloids, tannins, flavonoids, saponins, anthraquinones and cardiac glycosides, ellagic acid, triterpenoids, β- sitosterol. Polyphenols are considered to be potential in providing health benefits via modulation the gut microecology. Alteration of the gut microbiota composition can be achieved by consuming of flavonol-rich foods that exerting prebiotic-like effects. Short chain fatty acids (SCFA) that are produced from highly fermentable fibers is considered to be protective against colon cancer. Subjects were assigned consecutively into two group: ethanolic extract of A. muricata, and maltose as placebo. Ssupplementation was conducted for 8 weeks in a capsule. SCFA level assessment was conducted at baseline and the end of the study period. Gas liquid chromatography was used to determine concentration of butyrate. Fiber intake was measured using food record. Concentrations of fecal butyrate levelwas not significantly different between Fraction of A. muricata water extract that is soluble in ethanol (FAMSE) and placebo (p=0.854). Level of others SCFA were also not significantly different. The low fiberintakeisconsistent with the finding on fecal butyrate concentration, as shown by no significant increase in both groups. There is no statistically significant effect of supplementation with ethanol-soluble fraction of A muricata leaves water extract on fecal SCFA level of colo rectal cancer (CRC) patients, andin line with fiber intake below recommended daily allowance throughout the study period. \u0000Keywords: phytochemical substances, fiber intake, gut microbiota \u0000Abstrak \u0000Daun sirsak (Annona muricata) mengandung senyawa fitokimia seperti alkaloid, tanin, flavonoid, saponin, antraquinon, cardiac glycosides, ellagic acid, triterpenoid, dan β-sitosterol. Polifenol memiliki potensi yang baik dalam kesehatan dengan cara memodulasi mikro-ekologi usus. Komposisi microbiota usus dapat berubah dengan cara mengkonsumsi makanan yang banyak mengandung flavonol yang memberikan efek seperti prebiotik. Asam lemak rantai pendek yang dihasilkan dari fermentasi tinggi serat dapat mencegah terjadinya kanker kolon. Subyek penelitian dibagi menjadi dua kelompok secara berurutan, yaitu ekstrak etanol Annonamuricata dan maltosa sebagai plasebo. Pemberian suplemen dilakukan selama 8 minggu dalam bentuk kapsul. Pengukuran kadar asam lemak rantai pendek dilakukan pada awal dan akhir masa studi ini. Pengukuran kadar asam butirat dilakukan dengan kromatografi gas. Asupan serat diukur berdasarkan catatan makanan. Konsentrasi kadar asam butirat pada feses tidak berbeda signifikan dengan fraksi ekstrak air Annona muricata yang larut di dalam etanol dan plasebo (p=0.854). Kadar dari asam lemak rantai pendek lainnya juga tidak berbeda nyata. Asupan serat yang rendah sejalan dengan pengukuran kadar asam butirat di feses yang menunjukkan tidak ada peningkatan secara signifikan pada kedua kelompok. Tidak terdapat pengar","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124613920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstrak Sindrom McCune-Albright (SMA) merupakan kelainan genetik kompleks yang ditandai dengan trias displasia fibrosa poliostotik, café-au-lait, dan hiperfungsi endokrin. Sindrom ini termasuk penyakit langka dengan prevalens sebesar 1 per 100.000 hingga 1.000.000 populasi. Mutasi somatik sporadik gen GNAS (Guanine Nucleotide binding protein Alpha Stimulating) pada kromosom 20q13, yang terjadi pada sindrom ini, mengakibatkan aktivasi G protein α-subunit (Gsα) berkepanjangan yang meningkatkan aktivitas dan fungsi sel terkait. Manifestasi tersering yang ditemukan pada pasien adalah displasia fibrosa (pada 98% kasus). Kasus adalah seorang anak lelaki, 10 tahun, dengan manifestasi fraktur berulang sejak usia 1 tahun dan deformitas tulang. Pemeriksaan bone survey menunjukkan gambaran ground glass dengan lesi litik-sklerotik pada hampir semua tulang yang sesuai dengan displasia fibrosa poliostotik. Pasien ditata laksana dengan pemberian sediaan fosfat, kalsium, serta vitamin D dalam bentuk aktif dan analog. Pemberian bisfosfonat bertujuan untuk mengurangi nyeri tulang dan risiko fraktur pada pasien. Pemantauan berkelanjutan diperlukan untuk mengevaluasi keterlibatan organ endokrin pada pasien dengan SMA. Kata kunci: displasia fibrosa, fraktur, sindrom McCune Albright Abstract McCune-Albright syndrome (MAS) is a rare complex genetic disorder marked by the triad of polyostotic fibrous dysplasia, café-au-lait and endocrine hyperfunction, affecting 1 in 100.000 to 1.000.000 population. The sporadic somatic mutation of Guanine Nucleotide Binding Protein Alpha Stimulating (GNAS) gene at chromosome 20q13 is the proposed cause of this syndrome, triggering the prolonged activation of G protein α-subunit (Gsα), which increases the activity and function of cells. The most common clinical manifestation is fibrous dysplasia, occurring in 98% cases. This case occurred in a 10-year-old boy with recurrent fractures since the age of 1-year-old and skeletal deformities. The bone survey examination shows ground glass appearance with multiple sclerotic-lytic lesions on almost every bone, accordingly to the polyostotic fibrous dysplasia. The pasien has been treated with oral phosphate, calcium and vitamin D. Intravenous bisphosphonates was administered to relieve the associated bone pain and reduce the risk of recurring fractures. Longitudinal observation is necessary for a long term monitoring to evaluate the endocrinopathy associated with MAS. Keywords: fibrous dysplasia, fractures, McCune-Albright syndrome,
{"title":"Sindrom McCune Albright Dengan Manifestasi Fraktur Berulang","authors":"Ruth Nadya, Frida Soesanti","doi":"10.33541/mk.v36i1.2989","DOIUrl":"https://doi.org/10.33541/mk.v36i1.2989","url":null,"abstract":"Abstrak \u0000Sindrom McCune-Albright (SMA) merupakan kelainan genetik kompleks yang ditandai dengan trias displasia fibrosa poliostotik, café-au-lait, dan hiperfungsi endokrin. Sindrom ini termasuk penyakit langka dengan prevalens sebesar 1 per 100.000 hingga 1.000.000 populasi. Mutasi somatik sporadik gen GNAS (Guanine Nucleotide binding protein Alpha Stimulating) pada kromosom 20q13, yang terjadi pada sindrom ini, mengakibatkan aktivasi G protein α-subunit (Gsα) berkepanjangan yang meningkatkan aktivitas dan fungsi sel terkait. Manifestasi tersering yang ditemukan pada pasien adalah displasia fibrosa (pada 98% kasus). Kasus adalah seorang anak lelaki, 10 tahun, dengan manifestasi fraktur berulang sejak usia 1 tahun dan deformitas tulang. Pemeriksaan bone survey menunjukkan gambaran ground glass dengan lesi litik-sklerotik pada hampir semua tulang yang sesuai dengan displasia fibrosa poliostotik. Pasien ditata laksana dengan pemberian sediaan fosfat, kalsium, serta vitamin D dalam bentuk aktif dan analog. Pemberian bisfosfonat bertujuan untuk mengurangi nyeri tulang dan risiko fraktur pada pasien. Pemantauan berkelanjutan diperlukan untuk mengevaluasi keterlibatan organ endokrin pada pasien dengan SMA. \u0000 Kata kunci: displasia fibrosa, fraktur, sindrom McCune Albright \u0000Abstract \u0000McCune-Albright syndrome (MAS) is a rare complex genetic disorder marked by the triad of polyostotic fibrous dysplasia, café-au-lait and endocrine hyperfunction, affecting 1 in 100.000 to 1.000.000 population. The sporadic somatic mutation of Guanine Nucleotide Binding Protein Alpha Stimulating (GNAS) gene at chromosome 20q13 is the proposed cause of this syndrome, triggering the prolonged activation of G protein α-subunit (Gsα), which increases the activity and function of cells. The most common clinical manifestation is fibrous dysplasia, occurring in 98% cases. This case occurred in a 10-year-old boy with recurrent fractures since the age of 1-year-old and skeletal deformities. The bone survey examination shows ground glass appearance with multiple sclerotic-lytic lesions on almost every bone, accordingly to the polyostotic fibrous dysplasia. The pasien has been treated with oral phosphate, calcium and vitamin D. Intravenous bisphosphonates was administered to relieve the associated bone pain and reduce the risk of recurring fractures. Longitudinal observation is necessary for a long term monitoring to evaluate the endocrinopathy associated with MAS. \u0000 Keywords: fibrous dysplasia, fractures, McCune-Albright syndrome,","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132123279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstrak Laju filtrasi glomerulus (LFG) adalah kecepatan filtrasi volume plasma melalui ginjal per unit waktu per luas permukaan tubuh (LPB) dan merupakan salah satu indikator utama untuk pemantauan fungsi ginjal. Standar baku emas untuk menentukan LFG saat ini adalah dengan menghitung klirens inulin ginjal. Akan tetapi, karena prosedur tersebut dinilai kompleks, maka klirens inulin tidak digunakan dalam praktik klinik. Estimasi LFG menggunakan penanda eksogen lainnya seperti kreatinin serum dan sistatin C merupakan pilihan praktis yang dapat menggantikan perhitungan klirens inulin ginjal. Penentuan LFG pada anak berbeda dengan pada dewasa karena tidak mudah mengumpulkan urin per hari pada anak, sehingga diperlukan formula untuk mempermudah menentukan LFG. Berbagai peneliti telah melakukan penelitian untuk menemukan rumus untuk menentukan LFG dengan mudah dan praktis. Pemeriksaan LFG biasanya dilakukan berbasis klirens kreatinin dan belakangan ini dilakukan degan pemeriksaan sistatin C. Beberapa penanda yang digunakan untuk pengukuran LFG antara lain zat radiofarmaka seperti chromium 51-labeled ethylenediaminetetraacetic acid (51Cr-EDTA), technetium 99-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA), iodine 125-labeled iothalamate (125I-iothalamate), dan zat kontras radiografik. Dari berbagai rumus estimasi LFG, salah satu yang kini direkomendasikan untuk digunakan pada praktik klinis sehari-hari adalah rumus Schwartz yang dimodifikasi, karena dinilai sederhana, relatif akurat, tidak invasif, dan tidak membutuhkan biaya yang mahal. Kata kunci: laju filtrasi glomerulus, penyakit ginjal pada anak, kreatinin, sistatin C Abstract Glomerular filtration rate (GFR), which represents the plasma volume filtered through the kidney for each time unit and body surface area (BSA) unit, is one of the main indicators for renal function. The current gold standard for determining GFR is by calculating the renal inulin clearance. However, because this involves a complex procedure, inulin clrearance was not used in clinical practice. GFR estimation using other exogenous markers such as serum creatinine and cystatin C can be considered as practical alternatives. Determining GFR in children is difference with in adult because difficulty of 24 hours urine collection in children, so iti is needed a simple formula for determining GFR. Some researchers performed studies for determining easy and practical formula. GFR examinations usually based on creatinine clearance and nowadays by cyatatin C examination. Some markers are used in measuring of GFR such as chromium 51-labeled ethylenediaminetetraacetic acid (51Cr-EDTA), technetium 99-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA), iodine 125-labeled iothalamate (125I-iothalamate), and radiographic contrast. Among the various existing formulas to estimate GFR, one of the most commonly recommended in daily clinical practice is the modified Schwartz formula, as it is thought to be simple, relatively acc
{"title":"Laju Filtrasi Glomerulus pada Anak: Metode Apa yang Digunakan?","authors":"Nitish Basant Adnani, Sudung O. Pardede","doi":"10.33541/mk.v36i1.2990","DOIUrl":"https://doi.org/10.33541/mk.v36i1.2990","url":null,"abstract":"Abstrak \u0000Laju filtrasi glomerulus (LFG) adalah kecepatan filtrasi volume plasma melalui ginjal per unit waktu per luas permukaan tubuh (LPB) dan merupakan salah satu indikator utama untuk pemantauan fungsi ginjal. Standar baku emas untuk menentukan LFG saat ini adalah dengan menghitung klirens inulin ginjal. Akan tetapi, karena prosedur tersebut dinilai kompleks, maka klirens inulin tidak digunakan dalam praktik klinik. Estimasi LFG menggunakan penanda eksogen lainnya seperti kreatinin serum dan sistatin C merupakan pilihan praktis yang dapat menggantikan perhitungan klirens inulin ginjal. Penentuan LFG pada anak berbeda dengan pada dewasa karena tidak mudah mengumpulkan urin per hari pada anak, sehingga diperlukan formula untuk mempermudah menentukan LFG. Berbagai peneliti telah melakukan penelitian untuk menemukan rumus untuk menentukan LFG dengan mudah dan praktis. Pemeriksaan LFG biasanya dilakukan berbasis klirens kreatinin dan belakangan ini dilakukan degan pemeriksaan sistatin C. Beberapa penanda yang digunakan untuk pengukuran LFG antara lain zat radiofarmaka seperti chromium 51-labeled ethylenediaminetetraacetic acid (51Cr-EDTA), technetium 99-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA), iodine 125-labeled iothalamate (125I-iothalamate), dan zat kontras radiografik. Dari berbagai rumus estimasi LFG, salah satu yang kini direkomendasikan untuk digunakan pada praktik klinis sehari-hari adalah rumus Schwartz yang dimodifikasi, karena dinilai sederhana, relatif akurat, tidak invasif, dan tidak membutuhkan biaya yang mahal. \u0000 Kata kunci: laju filtrasi glomerulus, penyakit ginjal pada anak, kreatinin, sistatin C \u0000Abstract \u0000Glomerular filtration rate (GFR), which represents the plasma volume filtered through the kidney for each time unit and body surface area (BSA) unit, is one of the main indicators for renal function. The current gold standard for determining GFR is by calculating the renal inulin clearance. However, because this involves a complex procedure, inulin clrearance was not used in clinical practice. GFR estimation using other exogenous markers such as serum creatinine and cystatin C can be considered as practical alternatives. Determining GFR in children is difference with in adult because difficulty of 24 hours urine collection in children, so iti is needed a simple formula for determining GFR. Some researchers performed studies for determining easy and practical formula. GFR examinations usually based on creatinine clearance and nowadays by cyatatin C examination. Some markers are used in measuring of GFR such as chromium 51-labeled ethylenediaminetetraacetic acid (51Cr-EDTA), technetium 99-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA), iodine 125-labeled iothalamate (125I-iothalamate), and radiographic contrast. Among the various existing formulas to estimate GFR, one of the most commonly recommended in daily clinical practice is the modified Schwartz formula, as it is thought to be simple, relatively acc","PeriodicalId":308481,"journal":{"name":"Majalah Kedokteran UKI","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127313298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRAK Biji kakao adalah buah yang dikenal sejak dahulu sebagai buah yang memiliki peran penting dalam bidang kesehatan, salah satunya sebagai antibakteri. Biji kakao mengandung senyawa flavonoid, tanin, dan alkaloid yang memiliki efek antimikroba. Tujuan penelitian ini untuk mengetahui efektivitas ekstrak biji kakao terhadap bakteri Streptococcus pyogenes, yaitu dengan cara mengukur zona hambat menggunakan metode difusi Kirby-Beuer dengan konsentrasi ekstrak biji kakao 20%, 40%, 60%, 80% dan 100%. Hasil penelitian menunjukan ekstrak biji kakao dapat efektif memberikan efek antibakteri mulai dari konsentrasi terkecil 20% dengan rata-rata diameter zona hambat 8.07 mm sampai konsentrasi terbesar 100% dengan rata-rata diameter zona hambat 10.98 mm. Sedangkan rata-rata diameter zona hambat antibiotik Ampisilin sebagai kontrol (+) lebih besar dari konsentrasi ekstrak biji kakao. Berdasarkan data tersebut dapat disimpulkan ekstrak biji kakao dapat efektif menghambat pertumbuhan bakteri Streptococcus pyogenes Kata kunci: Kirby-Bauer, Zona Hambat, Antimikroba ABSTRACT Cocoa Seed is a fruit that has been known for a long time as a fruit that has an important role in health, which is as an antibacterial. Cocoa seeds contain a high composition of flavonoids, tannins, and alkaloids which have antimicrobial effects. The aim of this research was to study the effect of cocoa seed extracts against Streptococcus pyogenes, by measuring the inhibition zone using the Kirby-Bauer diffusion method using concentrations of cocoa seed extract 20%, 40%, 60%, 80% and 100%. The results showed that chocolate seed extract could effectively provide an antibacterial effect ranging from a concentration of 20% with an average diameter of inhibition zone of 8.07 mm to the largest concentration of 100% with an average zone diameter of inhibition of 10.98 mm. While the average diameter of the inhibitory zone of antibiotic ampicillin as a control (+) is greater than the concentration of cocoa seed extract. Based on these data, it can be concluded that cocoa seed extract can effectively inhibit the growth of Streptococcus pyogenes. Keywords: Kirby-Bauer, Inhibitory zone, Antimicrobial
可可豆是一种长期以来被称为健康水果的水果，其中一种是抗菌的。可可豆含有一种具有抗菌素特性的类黄酮、单宁和生物碱。本研究的目的是确定可可豆提取物对pyo吉尼斯链球菌的作用，即用kirbyberuer方法测量抑制区，其可可可豆提取物浓度为20%、40%、60%、80%和100%。研究表明，可可豆萃取物可以有效地从平均直径8.07毫米的最低浓度到平均直径10.98毫米的100%浓度。而氨比西林抗生素的平均直径，比可可豆提取物的浓度还要大。根据这些数据可以推断出可可豆提取物可以有效抑制细菌的生长链球菌、pyogenes关键词:抗菌素Kirby-Bauer区等等,抽象可可种子是一种水果,那已经知道for a long time)有一个重要角色的美国水果antibacterial的健康,这是美国。可可果果是一种高对苯酚、鞣质和生物碱的抗菌素。这项研究的目标是研究利用Kirby-Bauer衍生物方法利用cocoa seed extract pyogenes区的影响。结果表明，巧克力种子出口技术可以有效地提供一种抑制抑制效果的药物，这种影响可以从0.20%的平均直径为8.07毫米的感染区域达到100%与10.98毫米抑制剂的平均浓度。虽然抗生物感染区的平均直径比可可豆曝光的集中程度大。根据这些数据，它可以确定其中的可行性可能会影响链球菌的生长。柯本鲍尔，抑制区，抗微生物药
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