Biomacromolecules最新文献_第8页

Phosphorylated Lignin–Cellulose Nanofibrils: Elucidating the Preparation Pathway and Structural Features 磷酸化木质素-纤维素纳米原纤维：制备途径和结构特征的阐明。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c01763

Soumia Boukind , Amira Najahi , Houssine Khalili , Aleksander Jaworski , Jean-Luc Putaux , Sami Boufi , Houssine Sehaqui

Lignocellulosic nanofibrils (LCNFs) represent a promising resource-efficient alternative to lignin-free cellulose nanofibrils. Yet, developing eco-friendly pretreatments and energy-efficient disintegration of lignocellulosic biomass is essential to enable the facile production of high-quality LCNFs at low cost. This study addresses these challenges by producing multifunctional phosphorylated lignin-cellulose nanofibrils (PLCNFs) from giant reed fibers. PLCNFs containing 22.1 wt % lignin were produced through direct phosphorylation of unbleached fibers in an H₃PO₄/urea system, followed by alkali-swelling and microfluidization. This simple approach provided a higher yield than conventional lignin-free CNF production. The resulting PLCNFs exhibited a width of 3–5 nm, high aspect ratio, negative zeta potential (-30 mV), and shear-thinning behavior characteristic of a gel-like network. The incorporated phosphate moieties further enhanced flame retardancy. Overall, this work presents an inexpensive, energy-efficient, and sustainable approach to produce multifunctional PLCNFs from unbleached biomass, demonstrating the potential of renewable lignocellulosic resources for developing robust and eco-friendly nanostructured materials.

木质纤维素纳米原纤维（LCNFs）是一种有前途的资源节能型替代无木质素纤维素纳米原纤维。然而，开发生态友好的预处理和高效分解木质纤维素生物质对于以低成本轻松生产高质量的LCNFs至关重要。本研究通过从大芦苇纤维中生产多功能磷酸化木质素-纤维素纳米原纤维（PLCNFs）来解决这些挑战。通过在H3PO4/尿素体系中对未漂白的纤维进行直接磷酸化，然后进行碱膨胀和微流化，制备了含有22.1%木质素的PLCNFs。这种简单的方法提供了比传统的无木质素CNF生产更高的产量。所得的PLCNFs具有3-5 nm的宽度、高长宽比、负zeta电位（-30 mV）和凝胶状网络的剪切变薄行为特征。加入的磷酸盐部分进一步增强了阻燃性。总的来说，这项工作提出了一种廉价、节能和可持续的方法，从未漂白的生物质中生产多功能PLCNFs，展示了可再生木质纤维素资源在开发坚固且环保的纳米结构材料方面的潜力。

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引用次数: 0

Encapsulated Control: Shaping Insulin Fibrillation through Polymer Confinement 封装控制：通过聚合物约束塑造胰岛素纤颤。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c02110

Anastasiia Murmiliuk , Sergey K. Filippov , Hiroki Iwase , Kuno Schwärzer , Jürgen Allgaier , Aurel Radulescu

The understanding of insulin conformational changes trapped inside a polymeric capsule is obscure, especially at elevated temperatures above 40 °C. We studied the conformational changes of insulin in bulk solution and upon encapsulation into polymeric self-assemblies formed by poly(ethylene oxide)-block-poly(N,N,N-trimethylammonioethyl methacrylate) copolymer that is oppositely charged to the protein. We demonstrated that loading insulin into the nanoparticles does not affect its secondary structure but alters the pH sensitivity of insulin, making it more resistant to pH variation in the presence of the polymer. However, the temperature resistance of insulin is weakened in the environment of polyelectrolyte, which causes a lowering of the unfolding temperature, and the conformational changes begin already at 40 °C in the nanoparticle core. For the first time, we report that insulin fibrillation follows distinct pathways in free and encapsulated forms, a difference driven by insulin oligomeric state (hexamer in bulk and trimer within the polyelectrolyte/insulin complex).

聚合物胶囊内胰岛素构象变化的理解尚不清楚，特别是在40°C以上的高温下。我们研究了胰岛素在散装溶液中的构象变化，并将其包封成由聚（环氧乙烷）-嵌段聚（N，N，N-三甲基氨基甲基丙烯酸乙酯）共聚物形成的聚合物自组装体，该共聚物与蛋白质相反带电。我们证明，将胰岛素装载到纳米颗粒中不会影响其二级结构，但会改变胰岛素的pH敏感性，使其在聚合物存在的情况下更能抵抗pH变化。然而，胰岛素在聚电解质环境下的耐温性减弱，导致展开温度降低，纳米颗粒核心的构象变化已经在40℃时开始。我们首次报道了胰岛素纤颤在自由和封装形式下遵循不同的途径，这一差异是由胰岛素寡聚物状态（聚电解质/胰岛素复合物中的六聚体和三聚体）驱动的。

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引用次数: 0

Aging of Phosphorylated Cellulose Nanofibers under Moist-Heat Conditions 磷酸化纤维素纳米纤维在湿热条件下的老化研究。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c01635

Akane Sakiyama , Tsuguyuki Saito , Audrey Moores , Masato Kato , Shuji Fujisawa

Understanding the long-term stability of cellulose nanofibers is critical for their practical application in advanced functional materials. In this study, we investigated the aging behavior of phosphorylated cellulose nanofibers (PCNFs) sheets under moist-heat accelerated aging conditions (80 °C, 65% relative humidity (RH)) for up to 42 days. PCNFs with different phosphate group densities were prepared by controlling the phosphorylation time, and their chemical and morphological changes were systematically analyzed. Liquid-sta³¹P NMR revealed a progressive transformation of surface phosphate esters into inorganic phosphate salts during aging. This dephosphorylation was thought to lead to a decrease in the pH within the sheets, which in turn promoted hydrolysis of the cellulose backbone. The resulting degradation manifested as decreases in the degree of polymerization (DP) and fibril length, particularly in PCNFs with higher surface charge. Conversely, the lateral crystallite size of the cellulose increased. These findings provide insights into PCNF aging and highlight the importance of controlling the initial phosphate ester structure and environmental conditions to increase the stability of PCNF-based materials in practical applications.

了解纤维素纳米纤维的长期稳定性对其在高级功能材料中的实际应用至关重要。在这项研究中，我们研究了磷酸化纤维素纳米纤维（PCNFs）薄片在湿热加速老化条件下（80°C， 65%相对湿度（RH））长达42天的老化行为。通过控制磷酸化时间，制备了不同磷酸基密度的PCNFs，并对其化学和形态变化进行了系统分析。液体- sta31p核磁共振显示，在老化过程中，表面磷酸酯逐渐转变为无机磷酸盐。这种去磷酸化被认为会导致薄片内pH值的降低，从而促进纤维素主链的水解。导致的降解表现为聚合度（DP）和纤维长度的降低，特别是在具有较高表面电荷的PCNFs中。相反，纤维素的横向晶粒尺寸增大。这些发现为PCNF老化提供了新的见解，并强调了控制初始磷酸酯结构和环境条件对于提高PCNF基材料在实际应用中的稳定性的重要性。

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引用次数: 0

Butyrate-Modified Hyaluronic Acid Ameliorates MPTP-Induced Parkinson’s Disease via Modulating PINK1/Parkin-Involved Mitophagy and Intestinal Flora 丁酸修饰的透明质酸通过调节PINK1/帕金森相关的线粒体自噬和肠道菌群改善mptp诱导的帕金森病

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c00967

Yu Sun , Li Cui , Wanqiu Peng , Rong Chen , Xueneng Guan , Jiangyun Liu

Parkinson’s disease (PD) is difficult to treat clinically and lacks an effective treatment. The aim of this study was to synthesize and characterize butyrate-modified hyaluronic acid (HA-But), validate its therapeutic efficacy, and elucidate its mechanisms of action in PD. Behavioral tests, including the open field test, Y-maze, and elevated plus maze test, demonstrated that HA-But significantly alleviated motor dysfunction in PD mice. ELISA results indicated a marked reduction in pro-inflammatory cytokine levels following the HA-But treatment. In addition, immunohistochemistry, immunofluorescence, and Western blot analyses revealed that HA-But improved dopaminergic neuron survival and reduced α-synuclein aggregation. Furthermore, HA-But activated PINK1/Parkin-mediated mitophagy, modulated gut microbiota composition, and increased short-chain fatty acid (SCFA) levels, especially butyric acid. Combining HA-But with gastrodin further improved the PD symptoms in mice. These findings suggested the potential of HA-But as a novel approach for PD treatment.

帕金森病（PD）临床治疗困难，缺乏有效的治疗方法。本研究的目的是合成并表征丁酸酯修饰透明质酸（ha -但），验证其治疗PD的疗效，并阐明其作用机制。行为学实验，包括空旷场实验、y型迷宫实验和高架正迷宫实验，证实ha - a可显著缓解PD小鼠的运动功能障碍。ELISA结果显示，ha - a治疗后，促炎细胞因子水平明显降低。此外，免疫组织化学、免疫荧光和Western blot分析显示，ha - a可改善多巴胺能神经元的存活，减少α-突触核蛋白聚集。此外，ha - a还激活了PINK1/帕金森介导的线粒体自噬，调节了肠道菌群组成，增加了短链脂肪酸（SCFA）水平，尤其是丁酸。ha - a联合天麻素进一步改善了小鼠PD症状。这些发现提示ha - a作为一种治疗PD的新方法的潜力。

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引用次数: 0

Synthesis, Supramolecular Assembly, and Hydrogelation of Poly(amino ester) ABA Triblock Copolymers 聚氨基酯ABA三嵌段共聚物的合成、超分子组装和水解。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c01828

Chloé Pascouau , Kamila Wittek , Jessica Erlenbusch , Sebastian Becker , Jochen Fischer-Schuch , Pablo G. Argudo , Pol Besenius

Poly(amino esters) derived from N-acylated-1,4-oxazepan-7-ones (OxPs) emerge as promising candidates in the development of new and degradable amphiphiles for hydrogel preparation and delivery formulations. Here, the synthesis of amphiphilic triblock copolymers by ring-opening copolymerization of OxP monomers with various pendant chains is reported. Copolymerization using organocatalysts and a bifunctional initiator afforded neutral P(OxP_Me)-b-P(OxP_Bn)-b-P(OxP_Me) and cationic P(OxP_NH2 ⁺)-b-P(OxP_Bn)-b-P(OxP_NH2 ⁺) amphiphilic triblock copolymers with controlled molar masses ranging from 4,600 to 8,500 g/mol and narrow dispersities (Đ ≤ 1.21). A panel of polymers with various block lengths and compositions was synthesized. Their self-assembly in water revealed the formation of nanostructures, including worm-like or spherical morphologies. Modulation of the copolymer composition and concentration enables control over hydrogelation and its macroscopic properties. Finally, we investigated the formulation of a hydrophobic fungicide and its inhibitory effect on spore proliferation, which shows great promise as dispensable and biodegradable hydrogel formulation for agrochemical applications.

从n-酰基化-1,4-恶唑潘-7-酮（oxp）衍生的聚氨基酯在开发新的可降解两亲性水凝胶制备和递送配方中具有广阔的前景。本文报道了用开环共聚法合成两亲性三嵌段共聚物的方法。用有机催化剂和双功能引发剂共聚得到中性P(OxPMe)-b-P(OxPBn)-b-P（OxPMe）和阳离子P(OxPNH2+)-b-P（OxPNH2+）两亲性三嵌段共聚物，其摩尔质量在4,600 ~ 8,500 g/mol之间，分散度窄（Đ≤1.21）。合成了具有不同嵌段长度和组成的聚合物面板。它们在水中的自组装揭示了纳米结构的形成，包括蠕虫状或球形形态。调节共聚物的组成和浓度可以控制水凝胶作用及其宏观性质。最后，我们研究了一种疏水杀菌剂的配方及其对孢子增殖的抑制作用，该配方作为可生物降解的水凝胶制剂在农化应用中具有很大的前景。

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引用次数: 0

Pretargeted Polymeric Systems for Conducting Chemo-Radiotherapy on Glioblastoma: An Evaluation of the Impact of Nanomedicine Structure on Bioorthogonal Chemistry In Vivo 用于胶质母细胞瘤化疗的预靶向聚合物系统：纳米药物结构对体内生物正交化学影响的评估。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c01157

Weijing Chu , Gayathri R. Ediriweera , Amber Prior , Pie Huda , Benedict Lum , Christopher B. Howard , Nicholas L. Fletcher , Paul V. Bernhardt , Kristofer J. Thurecht

This study developed a nanoscaled system combining chemotherapeutic (Temozolomide, TMZ) and radionuclide (¹⁷⁷Lu) for targeted glioblastoma (GBM) treatment. Bioorthogonal click chemistry was utilized to produce a selective delivery platform, and the impacts of nanomedicine structure on the efficiency of bioorthogonal reactions were explored in vivo. This was achieved by developing two parallel polymers with trans-cyclooctene (tCO) in positions differing in terms of the accessibility to the tetrazine-containing moiety. Both in vitro assessment of reaction kinetics and the in vivo distribution behavior demonstrated that tCO conjugated at the chain end of the polymer (PTtCO_ext) instead of those within chains (PTtCO_int) exhibited better accessibility to the tetrazine-modified material ([¹⁷⁷Lu]Lu-DPT). This then led to a more efficient click reaction in vivo and higher ¹⁷⁷Lu accumulation in the tumor. This study provides key information on design considerations for optimal positioning of bioorthogonal reactive species in nanomedicine and a potential treatment approach for GBM.

本研究开发了一种纳米级联合化疗药物（替莫唑胺，TMZ）和放射性核素（177Lu）用于靶向治疗胶质母细胞瘤（GBM）的系统。利用生物正交点击化学构建了选择性给药平台，并在体内探讨了纳米药物结构对生物正交反应效率的影响。这是通过开发两种平行聚合物，其反式环烯（tCO）的位置不同，以接近含四氮的部分。反应动力学的体外评价和体内分布行为都表明，在聚合物链端偶联的tCO （PTtCOext）比在链内的tCO （PTtCOint）对四嗪修饰材料（[177Lu]Lu-DPT）具有更好的接近性。这导致了体内更有效的点击反应和更高的177Lu在肿瘤中的积累。该研究为纳米医学中生物正交反应物质的最佳定位设计提供了关键信息，并为GBM的潜在治疗方法提供了关键信息。

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引用次数: 0

Triple-Dynamic-Bond-Engineered Self-Healing Conductive Hydrogels for Deformation-Immune Flexible Supercapacitors and Wearable Epidermal Sensors 用于变形免疫柔性超级电容器和可穿戴表皮传感器的三动态键工程自修复导电水凝胶。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c02106

Lixia Liao , Jiaqi Ding , Xiao Xiong , Fengjiao Quan , Xingxing Liu , Min Zhu , Zehui Chen , Sheng Li , Lian Zhu , Benmei Wei , Juntao Zhang , Haibo Wang

Conductive hydrogels are promising for flexible electronics, yet integrating high conductivity, mechanical robustness, biocompatibility, and environmental stability for flexible supercapacitors (FSCs) and wearable epidermal sensors remains challenging. Herein, a self-healing hydrogel with multiple energy dissipation pathways was constructed using synergistic dynamic borate ester bonds, Schiff base bonds, and hydrogen bonds. Incorporating polydopamine-coated MXene (MP) enhanced the mechanical strength, conductivity, and antibacterial/antioxidant properties. FSCs with the hydrogel electrolyte exhibited excellent electrochemical performance with a specific capacitance of 373.41 mF/cm², an energy density of 74.67 μWh/cm², a capacitance retention of 82.43% after 5000 cycles, and high deformation tolerance. As a strain sensor, it effectively detected both large and subtle human motions, including physiological microexpressions and pulse beats due to its high sensitivity (gauge factor = 1.73) and repeatability. Importantly, its notable degradability owing to the inherent degradability of the chitosan framework and the reversible dissociation of dynamic bonds addresses environmental concerns from traditional electronics.

导电性水凝胶在柔性电子产品方面很有前景，但将高导电性、机械稳健性、生物相容性和环境稳定性集成到柔性超级电容器（fsc）和可穿戴表皮传感器中仍然具有挑战性。本文利用协同动态硼酸酯键、希夫碱键和氢键构建了具有多种能量耗散途径的自愈水凝胶。加入聚多巴胺包被的MXene （MP）增强了机械强度、电导率和抗菌/抗氧化性能。采用水凝胶电解质制备的FSCs具有优异的电化学性能，比电容为373.41 mF/cm2，能量密度为74.67 μWh/cm2，循环5000次后电容保持率为82.43%，且具有较高的抗变形能力。作为一种应变传感器，它具有很高的灵敏度（测量因子= 1.73）和可重复性，可以有效地检测人体的大的和细微的运动，包括生理微表情和脉搏跳动。重要的是，由于壳聚糖框架固有的可降解性和动态键的可逆解离，其显著的可降解性解决了传统电子产品的环境问题。

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引用次数: 0

Distinct Local and Global Dynamics of α‑Helices and β‑Sheets in Poly(γ-benzyl‑l‑glutamate) Peptides 聚γ-苄基-谷氨酸肽中α-螺旋和β-片的局部和全局动力学

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c02128

Marianna Spyridakou , Iren G. Stavrakaki , Evangelia Tsagkaraki , Christina Varfi , Robert Graf , Hermis Iatrou , George Floudas

A series of poly(γ-benzyl-l-glutamate) (PBLG) peptides are synthesized, with a broad range of molar masses and different end-groups. By combining static (wide-angle X-ray scattering and ¹³C solid-state nuclear magnetic resonance (NMR)) with dynamic probes (¹³C solid-state NMR, dielectric spectroscopy (DS) as a function of temperature and pressure, and rheology), we could identify distinct local and global dynamics associated with α-helices and β-sheets. The local dynamics reflect segmental relaxations of amorphous segments interrupting the α-helices/β-sheets and at their chain-ends. Two glass temperatures (T _gs) were identified in oligopeptides exhibiting both secondary structures. This is the first report for β-sheet-associated T _g in completely nonhydrated polypeptides. At longer timescales, the relaxation of the α-helical and β-sheet macrodipoles was also evident in DS. Peptides with different secondary structures have distinct viscoelastic signatures. Overall, polypeptide chain length and end-group chemistry can be employed to engineer α-helices and/or β-sheets, enabling deliberate control over the structural, dynamical, and viscoelastic properties.

合成了一系列具有广泛摩尔质量和不同端基的聚γ-苄基-谷氨酸（PBLG）多肽。通过将静态探针（广角x射线散射和13C固态核磁共振（NMR））与动态探针（13C固态核磁共振、介电光谱（DS）作为温度和压力的函数，以及流变学）相结合，我们可以识别出与α-螺旋和β-片相关的不同的局部和全局动力学。局部动力学反映了中断α-螺旋/β-片及其链端的非晶态片段弛豫。在具有两种二级结构的寡肽中鉴定出两种玻璃温度（Tgs）。这是在完全不水合多肽中首次报道β-薄片相关Tg。在较长的时间尺度上，DS中α-螺旋和β-片宏观偶极子的弛豫也很明显。具有不同二级结构的肽具有不同的粘弹性特征。总的来说，多肽链长度和端基化学可以用来设计α-螺旋和/或β-片，从而可以有意识地控制结构、动力学和粘弹性特性。

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引用次数: 0

Hydrolytically Stable Cationic Bis-MPA Dendrimers as Efficient Transfectants for Glioblastoma Cells and Primary Astrocytes 水解稳定的阳离子双mpa树突状分子作为胶质母细胞瘤细胞和初代星形胶质细胞的高效转染剂。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c01202

Angel Buendía , Natalia Sanz Del Olmo , Irene Rodríguez-Clemente , Jacob Wohlert , Krzysztof Sztandera , Jorge San Jacinto García , Faridah Namata , Michael Malkoch , Valentín Ceña

We report the biological evaluation of bis-MPA dendrimers terminated with either cysteamine (CYS) or 2-(dimethylamino)ethanethiol (DA) groups for siRNA transfection. The results show that aggregation phenomena are critical to the biological performance of these constructs. Confocal and 2D microscopy demonstrated that only the G3-CYS dendrimer transported siRNA into cells. Accordingly, G3-CYS-mediated siRNA transfection reduced intracellular levels of the target proteinsp42-MAPK, Rheb, and MGMTto 15–25% of control levels in a human glioblastoma cell line and mouse astrocytes. G3-CYS transfection efficiency was similar to that of commercial transfectants. However, its self-degradable bis-MPA backbone and tunable peripheral groups render it markedly superior, making it a promising transfection agent and emphasize the critical balance between structural design, biological efficacy, and safety. Despite its efficacy, G3-CYS displayed a narrow therapeutic window with pronounced cytotoxicity above 1 μM. In vivo studies further confirmed dose-dependent systemic toxicity, likely associated with enhanced blood coagulation.

我们报道了以半胱胺（CYS）或2-（二甲胺）乙硫醇（DA）组终止的双mpa树状大分子用于siRNA转染的生物学评价。结果表明，聚集现象对这些结构体的生物学性能至关重要。共聚焦显微镜和二维显微镜显示，只有G3-CYS树突状分子将siRNA转运到细胞中。因此，在人胶质母细胞瘤细胞系和小鼠星形胶质细胞中，g3 - cys介导的siRNA转染将靶蛋白p42-MAPK、Rheb和MGMT的细胞内水平降低到对照水平的15-25%。G3-CYS的转染效率与商品化的转染效率相近。然而，其自降解的双mpa主链和可调节的外周基团使其具有明显的优势，使其成为一种有前途的转染剂，并强调了结构设计，生物功效和安全性之间的关键平衡。尽管有疗效，但G3-CYS显示出狭窄的治疗窗口，1 μM以上的细胞毒性明显。体内研究进一步证实了剂量依赖性全身毒性，可能与凝血增强有关。

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引用次数: 0

Waste-to-Health Revolution: Upcycling Silk Sericin Byproducts into Circular Biomaterials for Biomedical Engineering 废物转化健康革命：将丝胶蛋白副产品升级为生物医学工程的循环生物材料。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules

Pub Date : 2026-01-12 DOI: 10.1021/acs.biomac.5c02248

Shicheng Xia , Jing Yang , Zhaoyang Wang , Shun Lu , Shanshan Wen , Kaiyu Guo , Lei Yang

Silk sericin (SS) is often regarded as a significant byproduct and discarded during degumming processes. Concerns over resource waste and environmental pollution have drawn widespread attention to the substantial amounts of waste SS generated during production. Effectively utilizing SS and applying it in the field of biomaterials presents both a major challenge and profound significance. With its biocompatibility and unique physical properties, SS can be transformed into multifunctional biomaterials through optimized extraction and purification processes. SS-based hydrogels, scaffolds, and bioinks exhibit excellent biocompatibility, controllable degradability, and cell-proliferation-promoting capabilities. These materials find applications in biomedical engineering, including wound repair dressings, drug delivery systems, antimicrobial agents, and tissue engineering scaffolds. Transforming SS into valuable resources not only reduces waste emissions from the silk processing industry but also pioneers a new pathway for developing low-cost, recyclable biomaterials. This approach holds broad application prospects in the biomedical field.

丝胶蛋白（SS）通常被视为脱胶过程中重要的副产品而被丢弃。对资源浪费和环境污染的担忧引起了人们对生产过程中产生的大量废SS的广泛关注。有效地利用SS并将其应用于生物材料领域是一项重大挑战，同时也具有深远的意义。SS具有良好的生物相容性和独特的物理性质，通过优化提取和纯化工艺，可以转化为多功能生物材料。基于ss的水凝胶、支架和生物墨水具有优异的生物相容性、可降解性和促进细胞增殖的能力。这些材料在生物医学工程中得到应用，包括伤口修复敷料、药物输送系统、抗菌剂和组织工程支架。将SS转化为有价值的资源不仅减少了丝绸加工业的废物排放，而且为开发低成本、可回收的生物材料开辟了一条新的途径。该方法在生物医学领域具有广阔的应用前景。

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引用次数: 0