Pub Date : 2021-01-01DOI: 10.21776/ub.mnj.2021.007.01.14
Evgenia Sergeevna Kurakina, E. Ioyleva, Mutlaq Ali Saif Saif, N. Gavrilova
Background: In recent decades, the problem of toxic damage of the visual system due to poisoning by various medicines has become particularly relevant. The clinical case of a bilateral acute optic neuropathy of toxic genesis in a patient by the unintentional application of closantel used in veterinary practice is presented in the report. Closantel is a structural derivative of the salicylanilides, which is used exclusively in veterinary medicine for the prevention and treatment of large and small-scale cattle. Neurological and ophthalmic symptoms are often associated with the intoxication of closantel. Objective: To describe the toxic damage of the optic nerve due to unintentional poisoning by closantel. Methods: A patient aged 55 years is examined. A standard survey of ophthalmology was carried out. Photoregistration of the ocular fundus was used by a funduscamera Visucam 500 (Carl Zeiss Meditec AG, Germany), from special methods of research - the spectral optical coherence tomography (OCT) with a study of the macular area of the retina and the disc of the optic nerve on the device Zeiss Cirrus 5000 (Carl Zeiss Meditec, USA) and the optical coherence tomography with the function of angiography (OCT-A) of the macular area of the retina using RTVue XR Avanti (Optovue, USA) Results: The patient complained of a severe, yet painless, reduction in vision of both eyes after an accidental intramuscular injection of the medicine called "Closantrem" in dose 4.0 ml. The visual acuity OU - an accounting of fingers on the face at a distance of 10 cm. By ophthalmoscopy OU: the disc of the optic nerve is discolourated, its boundaries are indistinct, the arteries and the veins are narrowed, in the macular area of the retina without a visible physical pathology. The perimetry is in the correct projection of the light. A reduction in the thickness of the external and internal layers of the retina was observed as a result of the OCT of the macular zone OU. According to OCT of the disc of the optic nerve: the thickness of the layer of nerve fibres is in the upper and lower nasal segments. OS – the prominence of the disc of the optic nerve in vitreous. The fascinated changes of the cerebral cortex have not been found during the MRT. The diagnosis was made OU: Acute optic neuropathy of toxic genesis. A course of integrated conservative treatment has been introduced: the anti-inflammatory, metabolic, nootropic, vitamin therapy, magnetotherapy, electrostimulation and electrophoresis. Conclusion: Potentially, any medicines are toxic, which may cause a number of side effects from the visual and central nervous system. The toxic damage of the ganglion cells of the retina was initially occurring due to unintentional application of closantel, resulting in a reduction of the central visual acuity, followed by the development of the optic nerve atrophy.
{"title":"THE DAMAGE OF THE OPTIC NERVE AS THE OUTCOME OF UNINTENTIONAL POISONING BY CLOSANTEL","authors":"Evgenia Sergeevna Kurakina, E. Ioyleva, Mutlaq Ali Saif Saif, N. Gavrilova","doi":"10.21776/ub.mnj.2021.007.01.14","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.14","url":null,"abstract":"Background: In recent decades, the problem of toxic damage of the visual system due to poisoning by various medicines has become particularly relevant. The clinical case of a bilateral acute optic neuropathy of toxic genesis in a patient by the unintentional application of closantel used in veterinary practice is presented in the report. Closantel is a structural derivative of the salicylanilides, which is used exclusively in veterinary medicine for the prevention and treatment of large and small-scale cattle. Neurological and ophthalmic symptoms are often associated with the intoxication of closantel. Objective: To describe the toxic damage of the optic nerve due to unintentional poisoning by closantel. Methods: A patient aged 55 years is examined. A standard survey of ophthalmology was carried out. Photoregistration of the ocular fundus was used by a funduscamera Visucam 500 (Carl Zeiss Meditec AG, Germany), from special methods of research - the spectral optical coherence tomography (OCT) with a study of the macular area of the retina and the disc of the optic nerve on the device Zeiss Cirrus 5000 (Carl Zeiss Meditec, USA) and the optical coherence tomography with the function of angiography (OCT-A) of the macular area of the retina using RTVue XR Avanti (Optovue, USA) Results: The patient complained of a severe, yet painless, reduction in vision of both eyes after an accidental intramuscular injection of the medicine called \"Closantrem\" in dose 4.0 ml. The visual acuity OU - an accounting of fingers on the face at a distance of 10 cm. By ophthalmoscopy OU: the disc of the optic nerve is discolourated, its boundaries are indistinct, the arteries and the veins are narrowed, in the macular area of the retina without a visible physical pathology. The perimetry is in the correct projection of the light. A reduction in the thickness of the external and internal layers of the retina was observed as a result of the OCT of the macular zone OU. According to OCT of the disc of the optic nerve: the thickness of the layer of nerve fibres is in the upper and lower nasal segments. OS – the prominence of the disc of the optic nerve in vitreous. The fascinated changes of the cerebral cortex have not been found during the MRT. The diagnosis was made OU: Acute optic neuropathy of toxic genesis. A course of integrated conservative treatment has been introduced: the anti-inflammatory, metabolic, nootropic, vitamin therapy, magnetotherapy, electrostimulation and electrophoresis. Conclusion: Potentially, any medicines are toxic, which may cause a number of side effects from the visual and central nervous system. The toxic damage of the ganglion cells of the retina was initially occurring due to unintentional application of closantel, resulting in a reduction of the central visual acuity, followed by the development of the optic nerve atrophy.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21776/ub.mnj.2021.007.01.2
D. Erawati, Y. Yueniwati
Background: Cranial ultrasound becomes an important diagnostic tool to evaluate brain injury in infants. Brain injury is a major complication for preterm birth. The brain injury of preterm infants differs from that of a term infant. Brain injury has correlation with gestational age and mode of delivery. Objective: To analyze the correlation between cranial ultrasound findings with gestational age and mode of delivery and to reveal if cranial ultrasound can be used to detect brain injury in premature infants. Methods: An observational analytic study using cross-sectional design took place in Saiful Anwar Hospital Malang, Indonesia. 38 healthy preterm infants underwent cranial ultrasound examination within the first four day of life. Fisher Exact test was used to analyze the correlation between cranial ultrasound findings with gestational age and mode of delivery. Results: Most of the healthy preterm infants (89.5%) were ≥ 32 weeks gestational age, and 52.6% of samples had caesarean section as their mode of delivery. There were three abnormal findings in cranial ultrasound; increased periventricular echogenic (5.3%), increased parenchym echogenic (5.3%), and indistinguishable of gray-white matter differentiation (5.3%). There was no significant correlation between abnormal cranial ultrasound findings with gestational age and mode of delivery (p= 0.202; p= 0.218). Conclusion: There were abnormal cranial ultrasound findings in some healthy preterm infants despite no significant correlation between ultrasound findings with gestational age and mode of delivery. Cranial ultrasound in preterm infants could become a screening tool for early detection of brain injury.
{"title":"CRANIAL ULTRASOUND: EFFICIENT SCREENING TOOL FOR EARLY DETECTION OF BRAIN INJURY IN PRETERM INFANTS","authors":"D. Erawati, Y. Yueniwati","doi":"10.21776/ub.mnj.2021.007.01.2","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.2","url":null,"abstract":"Background: Cranial ultrasound becomes an important diagnostic tool to evaluate brain injury in infants. Brain injury is a major complication for preterm birth. The brain injury of preterm infants differs from that of a term infant. Brain injury has correlation with gestational age and mode of delivery. Objective: To analyze the correlation between cranial ultrasound findings with gestational age and mode of delivery and to reveal if cranial ultrasound can be used to detect brain injury in premature infants. Methods: An observational analytic study using cross-sectional design took place in Saiful Anwar Hospital Malang, Indonesia. 38 healthy preterm infants underwent cranial ultrasound examination within the first four day of life. Fisher Exact test was used to analyze the correlation between cranial ultrasound findings with gestational age and mode of delivery. Results: Most of the healthy preterm infants (89.5%) were ≥ 32 weeks gestational age, and 52.6% of samples had caesarean section as their mode of delivery. There were three abnormal findings in cranial ultrasound; increased periventricular echogenic (5.3%), increased parenchym echogenic (5.3%), and indistinguishable of gray-white matter differentiation (5.3%). There was no significant correlation between abnormal cranial ultrasound findings with gestational age and mode of delivery (p= 0.202; p= 0.218). Conclusion: There were abnormal cranial ultrasound findings in some healthy preterm infants despite no significant correlation between ultrasound findings with gestational age and mode of delivery. Cranial ultrasound in preterm infants could become a screening tool for early detection of brain injury.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21776/ub.mnj.2021.007.01.4
Elena Ghentilis Fitri Amelia, A. Turchan, Nancy Margarita Rehatta, H. Hidayati
Background: Trigeminal Neuralgia is a common condition of facial pain and its significantly affect patients’ daily life. Microvascular decompression is one of the interventional pain management for trigeminal neuralgia. There is still a little data obtained on evaluation of facial pain after microvascular decompression in Indonesia. Objective: This research aimed to evaluate facial pain after microvascular decompression of trigeminal neuralgia patients in Dr. Soetomo General Hospital, PHC Hospital, and Bangil General Hospital, Indonesia. Methods: The research design was a pretest-posttest with total sampling. Data were obtained from medical records from January 2018 until June 2019. Researches used Numeric Rating Scale (NRS) as pain measurement. The data obtained were analyzed by descriptive statistical test, normality test, and paired t-test. Results: Trigeminal Neuralgia patients that has been treated with microvascular decompression have an average facial reduction from 7.33±2.29 to 1.89±3.41 with p = 0.001. This result showed that the microvascular decompression has significantly reduce facial pain in patients with trigeminal neuralgia. Conclusion: Microvascular decompression significantly reduce the facial pain of trigeminal neuralgia patients.
{"title":"NUMERIC RATING SCALE ANALYSIS OF TRIGEMINAL NEURALGIA PATIENTS BEFORE AND AFTER MICROVASCULAR DECOMPRESSION","authors":"Elena Ghentilis Fitri Amelia, A. Turchan, Nancy Margarita Rehatta, H. Hidayati","doi":"10.21776/ub.mnj.2021.007.01.4","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.4","url":null,"abstract":"Background: Trigeminal Neuralgia is a common condition of facial pain and its significantly affect patients’ daily life. Microvascular decompression is one of the interventional pain management for trigeminal neuralgia. There is still a little data obtained on evaluation of facial pain after microvascular decompression in Indonesia. Objective: This research aimed to evaluate facial pain after microvascular decompression of trigeminal neuralgia patients in Dr. Soetomo General Hospital, PHC Hospital, and Bangil General Hospital, Indonesia. Methods: The research design was a pretest-posttest with total sampling. Data were obtained from medical records from January 2018 until June 2019. Researches used Numeric Rating Scale (NRS) as pain measurement. The data obtained were analyzed by descriptive statistical test, normality test, and paired t-test. Results: Trigeminal Neuralgia patients that has been treated with microvascular decompression have an average facial reduction from 7.33±2.29 to 1.89±3.41 with p = 0.001. This result showed that the microvascular decompression has significantly reduce facial pain in patients with trigeminal neuralgia. Conclusion: Microvascular decompression significantly reduce the facial pain of trigeminal neuralgia patients.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"7 1","pages":"17-19"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21776/ub.mnj.2021.007.01.5
E. Aydın
Background: Falls constitute a problem especially in individuals aged above 70 years in terms of fracture formation. Considering the etiology of falling, insufficiency of the blood flow which feeds the balance center in the brain may cause postural hypotension and vertigo and may lead to falling. Objective: In this study, we emphasized the importance of evaluating vertebrobasilar blood flow in the etiology of fractures in the elderly. Methods: This study was executed on 48 patients aged 70 years and older (28 females, 20 males, mean age 80.45), who were presented to the emergency department of Dumlupinar University Evliya Celebi Training and Research Hospital with hip fractures resulting from a simple fall around where they live, diagnosed with hip fractures and treated via joint prostheses or different internal and external fixation methods. After the stabilization of the patients' postoperative fractures, the carotid artery lumen and blood flow, vertebral arterial lumen, diameter and blood flow were examined via doppler ultrasonography. The control group was comprised of 48 patients aged 70 years and older (26 females, 22 males, mean age 75.52 years) who were presented to the Polyclinic of Neurology for routine examination and had no falling and fracture history, and the carotid artery and vertebral artery examination of this group was also performed by the same radiologist via doppler ultrasonography Results: In individuals aged above 70 years, temporary cerebral blood flow disorders are more severe in those with vertebrobasilar insufficiency. This study was conducted between 2015-2016 on 48 patients aged 70 years and older (28 females and 20 males), who were presented to the emergency department of Dumlupinar University Faculty of Medicine Training and Research Hospital and hospitalized due to hip fractures; the control group was comprised of 48 patients within the same age group, who were presented to the Polyclinic of Neurology with different complaints (26 females and 22 males).The vertebral arterial diameters and flow velocities of the patients were assessed via Doppler USG. Conclusion: The vertebral arterial diameters and flow velocities were found statistically lower in the patient group with fracture formation resulting from falling.We recommend taking precautions against the risk of falling in patients aged above 70 years who are found to have a flow decrease through carotid artery doppler USG at certain intervals.
背景:跌倒构成了一个问题，特别是在70岁以上的人骨折形成方面。从跌倒的病因来看，供给大脑平衡中枢的血流量不足可引起体位性低血压和眩晕，从而导致跌倒。目的:在本研究中，我们强调评估椎基底动脉血流在老年人骨折病因学中的重要性。方法:48例年龄在70岁及以上的患者(女性28例，男性20例，平均年龄80.45岁)，在Dumlupinar University Evliya Celebi Training and Research Hospital急诊科就诊，诊断为髋部骨折，并通过关节假体或不同的内外固定方法进行治疗。术后骨折稳定后，行多普勒超声检查颈动脉管腔及血流、椎动脉管腔、直径及血流。对照组患者48例，年龄在70岁及以上，其中女性26例，男性22例，平均年龄75.52岁，就诊于神经内科综合门诊进行常规检查，无跌倒及骨折史，本组患者颈动脉及椎动脉检查均由同一放射科医师行多普勒超声检查。在70岁以上的人群中，暂时性脑血流障碍在椎基底动脉功能不全的人群中更为严重。本研究于2015-2016年对48例70岁及以上的患者(女性28例，男性20例)进行了研究，这些患者因髋部骨折被送到Dumlupinar大学医学院培训与研究医院急诊科住院;对照组由48例同年龄组的患者组成，他们以不同的主诉来到神经病学综合诊所(女性26例，男性22例)。采用多普勒超声心动图测定患者椎动脉直径和血流速度。结论:跌落致骨折患者组椎动脉直径和血流速度均有统计学差异。我们建议年龄在70岁以上的患者，如果发现颈动脉多普勒USG在一定时间间隔内出现血流减少，应采取预防措施，以防止跌倒的风险。
{"title":"VERTEBROBASILAR BLOOD FLOW IN GERIATRIC PATIENTS WITH HIP FRACTURES","authors":"E. Aydın","doi":"10.21776/ub.mnj.2021.007.01.5","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.5","url":null,"abstract":"Background: Falls constitute a problem especially in individuals aged above 70 years in terms of fracture formation. Considering the etiology of falling, insufficiency of the blood flow which feeds the balance center in the brain may cause postural hypotension and vertigo and may lead to falling. Objective: In this study, we emphasized the importance of evaluating vertebrobasilar blood flow in the etiology of fractures in the elderly. Methods: This study was executed on 48 patients aged 70 years and older (28 females, 20 males, mean age 80.45), who were presented to the emergency department of Dumlupinar University Evliya Celebi Training and Research Hospital with hip fractures resulting from a simple fall around where they live, diagnosed with hip fractures and treated via joint prostheses or different internal and external fixation methods. After the stabilization of the patients' postoperative fractures, the carotid artery lumen and blood flow, vertebral arterial lumen, diameter and blood flow were examined via doppler ultrasonography. The control group was comprised of 48 patients aged 70 years and older (26 females, 22 males, mean age 75.52 years) who were presented to the Polyclinic of Neurology for routine examination and had no falling and fracture history, and the carotid artery and vertebral artery examination of this group was also performed by the same radiologist via doppler ultrasonography Results: In individuals aged above 70 years, temporary cerebral blood flow disorders are more severe in those with vertebrobasilar insufficiency. This study was conducted between 2015-2016 on 48 patients aged 70 years and older (28 females and 20 males), who were presented to the emergency department of Dumlupinar University Faculty of Medicine Training and Research Hospital and hospitalized due to hip fractures; the control group was comprised of 48 patients within the same age group, who were presented to the Polyclinic of Neurology with different complaints (26 females and 22 males).The vertebral arterial diameters and flow velocities of the patients were assessed via Doppler USG. Conclusion: The vertebral arterial diameters and flow velocities were found statistically lower in the patient group with fracture formation resulting from falling.We recommend taking precautions against the risk of falling in patients aged above 70 years who are found to have a flow decrease through carotid artery doppler USG at certain intervals.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"7 1","pages":"20-23"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-08DOI: 10.21776/ub.mnj.2020.006.02.11
N. Seidu, E. Poluyi, C. Ikwuegbuenyi, E. Morgan.
This review brings into view the prognosis attributable to glioblastoma (GBM) and resistance to treatment, surgical interventions and chemotherapy seem ineffective at procuring a better prognosis for patients with the disease. Albeit there exist varying interventions for GBM, the median survival still comes to 12 to 15 months for afflicted patients, this has aroused the need for improvement in treatment success The principal goal is to create a better prognosis and have a decline in treatment resistance invariably leading to better survival rates via adequate treatment for GBM. A relationship exists between HOX genes (homeobox genes) and glioblastoma as is evident from literature. Treatment resistance has been observed in overexpression of HOX genes, the effectiveness of treatment could result from silencing these genes A series of studies have highlighted the role that HOX genes play in glioblastoma prognosis. Promotion of human glioblastoma initiation, aggressiveness, and resistance to Temozolomide has been associated with HOXA9 as shown by Pojo et al. The role of HOX gene expression in cancer stem cells should be studied as it could provide a means of designing CSC-targeted therapies, as CSCs play a part in initiation and progression of solid tumors.
{"title":"HOXA GENE EXPRESSION IMPLICATED IN TREATMENT RESISTANCE AND POOR PROGNOSIS IN GLIOBLASTOMA","authors":"N. Seidu, E. Poluyi, C. Ikwuegbuenyi, E. Morgan.","doi":"10.21776/ub.mnj.2020.006.02.11","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.11","url":null,"abstract":"This review brings into view the prognosis attributable to glioblastoma (GBM) and resistance to treatment, surgical interventions and chemotherapy seem ineffective at procuring a better prognosis for patients with the disease. Albeit there exist varying interventions for GBM, the median survival still comes to 12 to 15 months for afflicted patients, this has aroused the need for improvement in treatment success The principal goal is to create a better prognosis and have a decline in treatment resistance invariably leading to better survival rates via adequate treatment for GBM. A relationship exists between HOX genes (homeobox genes) and glioblastoma as is evident from literature. Treatment resistance has been observed in overexpression of HOX genes, the effectiveness of treatment could result from silencing these genes A series of studies have highlighted the role that HOX genes play in glioblastoma prognosis. Promotion of human glioblastoma initiation, aggressiveness, and resistance to Temozolomide has been associated with HOXA9 as shown by Pojo et al. The role of HOX gene expression in cancer stem cells should be studied as it could provide a means of designing CSC-targeted therapies, as CSCs play a part in initiation and progression of solid tumors.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"105-110"},"PeriodicalIF":0.0,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45007900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-25DOI: 10.21776/ub.mnj.2020.006.02.8
Arina Windri Rivarti, L. Herawati, H. Hidayati
Increasing aging population causes an increased prevalence of neurodegenerative diseases such as dementia that is associated with memory decline. Developing strategies for the prevention and therapy of age-related dementia is important to reduce the burden of treatment costs. Physical exercise is known to prevent cognitive decline and improve cognitive abilities. Physical exercise with moderate intensity for at least 150 minutes/week or 30 minutes/day for 5 days can reduce the incidence of degenerative diseases in the elderly. Thus, physical exercise appears as a simple, inexpensive, and affordable non-pharmacological therapy for most people. The processes of neurogenesis and neuronal survival involve the role of neurotrophic factors including BDNF, IGF-1 and VEGF, which are the three main neurotrophic factors that are known to increase after exercise. Many publications discuss about these neurotrophic factors, but their mechanism of signals and changes related to aging and exercise have not been completely studied. The purpose of this review is to discuss the mechanism of signals and changes of neurotrophic factors (focuses on BDNF, IGF-1, and VEGF) related to aging and exercise.
{"title":"EXERCISE PREVENTS AGE-RELATED MEMORY DECLINE: THE ROLE OF NEUROTROPHIC FACTORS","authors":"Arina Windri Rivarti, L. Herawati, H. Hidayati","doi":"10.21776/ub.mnj.2020.006.02.8","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.8","url":null,"abstract":"Increasing aging population causes an increased prevalence of neurodegenerative diseases such as dementia that is associated with memory decline. Developing strategies for the prevention and therapy of age-related dementia is important to reduce the burden of treatment costs. Physical exercise is known to prevent cognitive decline and improve cognitive abilities. Physical exercise with moderate intensity for at least 150 minutes/week or 30 minutes/day for 5 days can reduce the incidence of degenerative diseases in the elderly. Thus, physical exercise appears as a simple, inexpensive, and affordable non-pharmacological therapy for most people. The processes of neurogenesis and neuronal survival involve the role of neurotrophic factors including BDNF, IGF-1 and VEGF, which are the three main neurotrophic factors that are known to increase after exercise. Many publications discuss about these neurotrophic factors, but their mechanism of signals and changes related to aging and exercise have not been completely studied. The purpose of this review is to discuss the mechanism of signals and changes of neurotrophic factors (focuses on BDNF, IGF-1, and VEGF) related to aging and exercise.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46966620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-25DOI: 10.21776/ub.mnj.2020.006.02.7
Aprillia Mauren Pariama, Yulius Yusak Ranimpi, A. Setiawan
Background: Dementia is a syndrome caused by decreased cognitive function due to aging, genetics, vascular disease and low physical and cognitive activities. Alzheimer's is the most common cause of dementia. Despite experiencing holistic changes in their lives, elderly with dementia Alzheimer's are entitled to well-being. Measurement of Subjective Well-being (SWB) is used to determine the well-being state of elderlies. Objective: The purpose of this study is to analyze the expression of Subjective well-being (SWB) and the healthy behavior of elderlies with dementia Alzheimer's. Methods: This study uses a qualitative phenomenological approach with a descriptive hermeneutics type. The data collection was done by in-depth interview techniques with the type of auto-anamnesis, observed, and family statements. The data analysis process was carried out in 3 stages (Verbatim, initial and focused coding, determination of categories were made in the form of themes). Data validity test used data triangulation techniques. Results: Participants in this study are 3 elderlies age 75 and 76 years who had mild dementia Alzheimer's. This condition affects participants ability in expressing their SWB and health behavior that are described in physical disorders, life satisfaction, satisfaction with important domains, positive influence, behavior change, treatment-seeking, and cognitive failure. Conclusion: Reported high subjective well-being is closely related to the low level of unpleasant emotions during their life journey. Healthy behavior is strongly influenced by knowledge, demographic factors, personal goals and values, social influence, and access to health services. Two participants managed to express SWB and healthy behaviors better than one participant.
{"title":"SUBJECTIVE WELL-BEING AND HEALTHY BEHAVIOR OF ELDERLY WITH DEMENTIA ALZHEIMER’S (A PHENOMENOLOGICAL STUDY)","authors":"Aprillia Mauren Pariama, Yulius Yusak Ranimpi, A. Setiawan","doi":"10.21776/ub.mnj.2020.006.02.7","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.7","url":null,"abstract":"Background: Dementia is a syndrome caused by decreased cognitive function due to aging, genetics, vascular disease and low physical and cognitive activities. Alzheimer's is the most common cause of dementia. Despite experiencing holistic changes in their lives, elderly with dementia Alzheimer's are entitled to well-being. Measurement of Subjective Well-being (SWB) is used to determine the well-being state of elderlies. Objective: The purpose of this study is to analyze the expression of Subjective well-being (SWB) and the healthy behavior of elderlies with dementia Alzheimer's. Methods: This study uses a qualitative phenomenological approach with a descriptive hermeneutics type. The data collection was done by in-depth interview techniques with the type of auto-anamnesis, observed, and family statements. The data analysis process was carried out in 3 stages (Verbatim, initial and focused coding, determination of categories were made in the form of themes). Data validity test used data triangulation techniques. Results: Participants in this study are 3 elderlies age 75 and 76 years who had mild dementia Alzheimer's. This condition affects participants ability in expressing their SWB and health behavior that are described in physical disorders, life satisfaction, satisfaction with important domains, positive influence, behavior change, treatment-seeking, and cognitive failure. Conclusion: Reported high subjective well-being is closely related to the low level of unpleasant emotions during their life journey. Healthy behavior is strongly influenced by knowledge, demographic factors, personal goals and values, social influence, and access to health services. Two participants managed to express SWB and healthy behaviors better than one participant.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42022034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-25DOI: 10.21776/ub.mnj.2020.006.02.6
Ria Damayanti, M. Husna, Yeni Quinta Mondiani, S. Kurniawan
Background: Epilepsy is a major chronic neurological problem in the world. The goal of epilepsy therapy is seizure-free and without side effects. The emergence of side effects in patients with epilepsy will be its limitations that can cause the failure of epilepsy therapy. Therefore, it is necessary to do a simple descriptive study, which illustrates the pattern of side effects of anti-epileptic drugs that occur in people with epilepsy, so that later clinicians are more alert and can take preventative measures. Objective: Knowing the pattern of side effects of antiepileptic drugs at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Methods: This research is an observational descriptive study. Samples were taken by filling the questionnaire at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Demographic data in this study will be presented in the frequency distribution table. Chi Square test is used to determine the relationship of demographic data, also the pattern of therapy with the side effects that arise. Results: 93 epilepsy patients were involved in the study. More than 40% of patients experience side effects. The most common side effects appear in idiopathic epilepsy (30.1%). Based on the duration of epilepsy, the most side effects appear in epilepsy duration> 10 years (17.2%). However, from the results of the influence test using chi square, there was no significant difference between the duration of epilepsy with the appearance of side effects, even the type of epilepsy (p-value> 0.05). 28 patients who experience side effects, appear after the duration of use of AED 1 - 5 years. It was found that the duration of AED uses affected the emergence of side effects (p-value <0.05). Conclusion: Side effects occur in patients taking anti-epileptic drugs, and are related to the duration of drug use. This data can be used to increase the awareness of clinicians related to the emergence of side effects in patients who consume AED.
{"title":"PATTERN OF ANTI EPILEPTIC DRUG ADVERSE EFFECT IN TERTIARY REFERRAL HOSPITAL","authors":"Ria Damayanti, M. Husna, Yeni Quinta Mondiani, S. Kurniawan","doi":"10.21776/ub.mnj.2020.006.02.6","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.6","url":null,"abstract":"Background: Epilepsy is a major chronic neurological problem in the world. The goal of epilepsy therapy is seizure-free and without side effects. The emergence of side effects in patients with epilepsy will be its limitations that can cause the failure of epilepsy therapy. Therefore, it is necessary to do a simple descriptive study, which illustrates the pattern of side effects of anti-epileptic drugs that occur in people with epilepsy, so that later clinicians are more alert and can take preventative measures. Objective: Knowing the pattern of side effects of antiepileptic drugs at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Methods: This research is an observational descriptive study. Samples were taken by filling the questionnaire at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Demographic data in this study will be presented in the frequency distribution table. Chi Square test is used to determine the relationship of demographic data, also the pattern of therapy with the side effects that arise. Results: 93 epilepsy patients were involved in the study. More than 40% of patients experience side effects. The most common side effects appear in idiopathic epilepsy (30.1%). Based on the duration of epilepsy, the most side effects appear in epilepsy duration> 10 years (17.2%). However, from the results of the influence test using chi square, there was no significant difference between the duration of epilepsy with the appearance of side effects, even the type of epilepsy (p-value> 0.05). 28 patients who experience side effects, appear after the duration of use of AED 1 - 5 years. It was found that the duration of AED uses affected the emergence of side effects (p-value <0.05). Conclusion: Side effects occur in patients taking anti-epileptic drugs, and are related to the duration of drug use. This data can be used to increase the awareness of clinicians related to the emergence of side effects in patients who consume AED.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46752568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-24DOI: 10.21776/ub.mnj.2020.006.02.5
S. Subandi, D. K. Mirawati, S. E. Putra, Muhammad Hafizhan, Wahyu Agung Susilo, R. Danuaji
Background : Carpal Tunnel Syndrome (CTS) is the most common mono-neuropathy caused by median nerve entrapment on the wrist. Major risk factor of the CTS is repetitive use of the hand, whether from occupational activities or hobbies. One of the most frequent occupation affected with CTS is the batik craftsmen. Objective : To investigate the relationship between working period of batik craftsmen with the incident of CTS at Kampung Batik Tulis Laweyan. Methods : Participants of this cross-sectional study were 30 batik craftsmen from Kampung Batik Tulis Laweyan who met the inclusion and exclusion criteria. They were classified into two groups based on working period (less or more than five years), clinically examined, and underwent the Nerve Conduction Velocity studies. Bland's classification was administered for grouping the nerve injury. Spearman correlation test was performed to investigate the correlation between working period and incident of CTS. Results: There was a significant medium positive correlation between working period and nerve injury based on Bland’s classification (r=0.559; p=0.013). While the chief complaints were also correlated with the working period, the association was not statistically significant (p=0.355). Conclusion: This research suggests an association between the incident of CTS and longer working period in batik craftsmen.
背景：腕管综合征（CTS）是由正中神经卡压引起的最常见的单核神经病变。CTS的主要危险因素是重复用手，无论是职业活动还是业余爱好。受华视影响最频繁的职业之一是蜡染工匠。目的：探讨蜡染工艺工人的工作时间与Kampung batik Tulis Laweyan CTS事件的关系。方法：这项横断面研究的参与者是来自Kampung batik Tulis Laweyan的30名蜡染工匠，他们符合纳入和排除标准。他们根据工作时间（少于或超过五年）分为两组，进行临床检查，并接受神经传导速度研究。采用布兰德分类法对神经损伤进行分组。采用Spearman相关试验研究CTS发生率与工作时间的相关性。结果：根据Bland分类，工作时间与神经损伤之间存在显著的中等正相关（r=0.559；p=0.013），结论：本研究表明蜡染工艺工人CTS的发生与较长的工作时间有关。
{"title":"THE RELATIONSHIP BETWEEN WORKING PERIOD OF BATIK CRAFTSMEN AND INCIDENT OF CARPAL TUNNEL SYNDROME","authors":"S. Subandi, D. K. Mirawati, S. E. Putra, Muhammad Hafizhan, Wahyu Agung Susilo, R. Danuaji","doi":"10.21776/ub.mnj.2020.006.02.5","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.5","url":null,"abstract":"Background : Carpal Tunnel Syndrome (CTS) is the most common mono-neuropathy caused by median nerve entrapment on the wrist. Major risk factor of the CTS is repetitive use of the hand, whether from occupational activities or hobbies. One of the most frequent occupation affected with CTS is the batik craftsmen. Objective : To investigate the relationship between working period of batik craftsmen with the incident of CTS at Kampung Batik Tulis Laweyan. Methods : Participants of this cross-sectional study were 30 batik craftsmen from Kampung Batik Tulis Laweyan who met the inclusion and exclusion criteria. They were classified into two groups based on working period (less or more than five years), clinically examined, and underwent the Nerve Conduction Velocity studies. Bland's classification was administered for grouping the nerve injury. Spearman correlation test was performed to investigate the correlation between working period and incident of CTS. Results: There was a significant medium positive correlation between working period and nerve injury based on Bland’s classification (r=0.559; p=0.013). While the chief complaints were also correlated with the working period, the association was not statistically significant (p=0.355). Conclusion: This research suggests an association between the incident of CTS and longer working period in batik craftsmen.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"73-76"},"PeriodicalIF":0.0,"publicationDate":"2020-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45436144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-24DOI: 10.21776/ub.mnj.2020.006.02.3
Fajri Andi Rahmawan, Y. Yueniwati, Tony Suharsono
Background: Ischemic stroke is an emergency state condition of brain which needs immediate rescue so the sufferer will not get any injury or risk of death. Interval of departing period still becomes problem. Level of severity perception and process of decision making of family are factors correlated to interval of departing time of the patient to Emergency Department. Objective: The purpose of this research is to find out correlation of severity level perception and process of decision making of family to interval of departing time of patient suffering stroke to Emergency Department of Public Regional Hospital Blambangan Banyuwangi. Methods: The method of this research is quantitative with cross sectional approach by involving 113 respondents. The technique of sampling is purposive sampling. The instruments are interview and observation sheet. The data analysis is done by spearman test to find out the correlation between variables namely level of severity and process of decision making of family’s patient to interval of departing time. Results: Findings show that p value between perceptions of severity level to the interval is 0.000 and process of decision making of the family to the interval with p value = 0.000 < α 0.05 meaning that variable of severity level and process of decision making are correlated to interval of departing time. Conclusion: Nurses need to improve standard of stroke severity by determining half-body weakening symptom into severity of ischemic stroke then it is socialized to society and to let them know the importance of immediate transport to emergency department when ischemic stroke symptom is found
{"title":"PERCEPTION OF SEVERITY LEVEL AND DECISION MAKING OF FAMILY CORRELATION TOWARD DEPARTING INTERVAL OF PATIENT SUFFERING ISCHEMIC STROKE","authors":"Fajri Andi Rahmawan, Y. Yueniwati, Tony Suharsono","doi":"10.21776/ub.mnj.2020.006.02.3","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.3","url":null,"abstract":"Background: Ischemic stroke is an emergency state condition of brain which needs immediate rescue so the sufferer will not get any injury or risk of death. Interval of departing period still becomes problem. Level of severity perception and process of decision making of family are factors correlated to interval of departing time of the patient to Emergency Department. Objective: The purpose of this research is to find out correlation of severity level perception and process of decision making of family to interval of departing time of patient suffering stroke to Emergency Department of Public Regional Hospital Blambangan Banyuwangi. Methods: The method of this research is quantitative with cross sectional approach by involving 113 respondents. The technique of sampling is purposive sampling. The instruments are interview and observation sheet. The data analysis is done by spearman test to find out the correlation between variables namely level of severity and process of decision making of family’s patient to interval of departing time. Results: Findings show that p value between perceptions of severity level to the interval is 0.000 and process of decision making of the family to the interval with p value = 0.000 < α 0.05 meaning that variable of severity level and process of decision making are correlated to interval of departing time. Conclusion: Nurses need to improve standard of stroke severity by determining half-body weakening symptom into severity of ischemic stroke then it is socialized to society and to let them know the importance of immediate transport to emergency department when ischemic stroke symptom is found","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2020-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49327110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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