Pub Date : 2016-01-01DOI: 10.21776/UB.MNJ.2016.002.01.3
M. Santoso, Masruroh Rahayu, Fachriy Balafif
Background. Epidural hematoma is intracranial hemorrhage, due to skull fracture caused by head injury which there is a blood accumulation between the layers of duramater and the skull. Objective. To determine the corellation of epidural hematoma trepanation respond time with outcome. Methods. A retrospective observational analytic study (cross sectional) with 30 samples taken in Saiful Anwar Hospital Malang from June to August 2012. The independent variable in this study is trepanation respond time that divided into trepanation respond time less than 6 hours, between 6-12 hours, between 12-18 hours, between 18-24 hours, and more than 24 hours while the dependent variable in this study is the outcome of the patient. Secondary data were taken using medical records. The data were analyzed using independent T-test, spearman correlation test, kruskall walis test, and ROC test with confidence level 95% (α=0.005). Results. The analysis shows a significant corelation between severe head injury epidural hematoma trepanation respond time with the outcome. Conclusion. Faster trepanation respond time will have better outcome.
{"title":"CORRELATION OF SEVERE HEAD INJURY EPIDURAL HEMATOMA TREPANATION RESPOND TIME WITH OUTCOME","authors":"M. Santoso, Masruroh Rahayu, Fachriy Balafif","doi":"10.21776/UB.MNJ.2016.002.01.3","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2016.002.01.3","url":null,"abstract":"Background. Epidural hematoma is intracranial hemorrhage, due to skull fracture caused by head injury which there is a blood accumulation between the layers of duramater and the skull. Objective. To determine the corellation of epidural hematoma trepanation respond time with outcome. Methods. A retrospective observational analytic study (cross sectional) with 30 samples taken in Saiful Anwar Hospital Malang from June to August 2012. The independent variable in this study is trepanation respond time that divided into trepanation respond time less than 6 hours, between 6-12 hours, between 12-18 hours, between 18-24 hours, and more than 24 hours while the dependent variable in this study is the outcome of the patient. Secondary data were taken using medical records. The data were analyzed using independent T-test, spearman correlation test, kruskall walis test, and ROC test with confidence level 95% (α=0.005). Results. The analysis shows a significant corelation between severe head injury epidural hematoma trepanation respond time with the outcome. Conclusion. Faster trepanation respond time will have better outcome.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"2 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-01DOI: 10.21776/UB.MNJ.2015.001.02.3
S. Sunarti, Masruroh Rahayu, Dimas Ryan Desetyaputra
Background. Delirium is a serious health problem and the most frequent complaints in geriatric patients. Objective. This research aims to analyzes the patient profile and the underlying disease of delirum by using descriptive study and survey methods. Methods. Subjects were geriatric patients with age >60 years old diagnosed with delirium. Results. Patients with delirium syndrome was male sex 58.3% and female sex 41,7%, the highest age group between 60-65 years was 31.7% and 66-70 years was 30%, education is the senior high school level of 41.7% and junior high school level of 35%. Temperature delirium patients that >37.5oC (61.7%) patients and GCS due to moderate state was 100% patients. Hb and PCV were below normal at 71.7% and 70%. Conditions out of the hospital patients delirum syndrome is to live for 71.7%. The most underlying disease delirium syndrome were CVA 56.7%, Diabetes Melitus type II 23,3% and Sepsis 8,3%. Conclusion. The factors underlying the occurrence of delirium syndrome are male sex, aged 60-65 years old, low education, temperatures above normal, decreased consciousness, low PCV, anemia and most diseases that cause delirium syndrome is CVA, Diabetes Melitus type II and Sepsis.
{"title":"GERIATRIC PATIENT WITH DELIRIUM PROFILE IN SAIFUL ANWAR GENERAL HOSPITAL MALANG FROM JANUARY 2005 UNTIL JUNE 2010","authors":"S. Sunarti, Masruroh Rahayu, Dimas Ryan Desetyaputra","doi":"10.21776/UB.MNJ.2015.001.02.3","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.02.3","url":null,"abstract":"Background. Delirium is a serious health problem and the most frequent complaints in geriatric patients. Objective. This research aims to analyzes the patient profile and the underlying disease of delirum by using descriptive study and survey methods. Methods. Subjects were geriatric patients with age >60 years old diagnosed with delirium. Results. Patients with delirium syndrome was male sex 58.3% and female sex 41,7%, the highest age group between 60-65 years was 31.7% and 66-70 years was 30%, education is the senior high school level of 41.7% and junior high school level of 35%. Temperature delirium patients that >37.5oC (61.7%) patients and GCS due to moderate state was 100% patients. Hb and PCV were below normal at 71.7% and 70%. Conditions out of the hospital patients delirum syndrome is to live for 71.7%. The most underlying disease delirium syndrome were CVA 56.7%, Diabetes Melitus type II 23,3% and Sepsis 8,3%. Conclusion. The factors underlying the occurrence of delirium syndrome are male sex, aged 60-65 years old, low education, temperatures above normal, decreased consciousness, low PCV, anemia and most diseases that cause delirium syndrome is CVA, Diabetes Melitus type II and Sepsis.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68323434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-01DOI: 10.21776/UB.MNJ.2015.001.02.4
S. Rianawati, Habiba Aurora, Yulia Nugrahanitya
Background. High blood pressure is the first risk factor in stroke, but it is possible that low blood pressure causes stroke, although it is a few incident. Objective. To know the relation between blood pressure on arrival time in stroke unit and the clinical outcome of acute thrombolytic stroke patients using NIHSS score. Methods. Using cohort retrospective study, 38 samples were selected by consecutive method. The variable measured in this research is systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) at the first time in stroke unit to NIHSS patients in the last day nursing (10-14 days). Results. Based from Spearman correlation test, SBP (p = 0,136; r = 0,246), DBP (p = 0,586; r = 0,091), and MAP (p = 0,171; r = 0,227) indicate that have not significant correlation with NIHSS and indicate that very weak correlation. Conclusion. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) have not significant correlation with NIHSS and indicate that very weak correlation. Study is needed to understand the relation without any treatment influence and confounding factor.
{"title":"CORRELATION BETWEEN BLOOD PRESSURE AT ADMITTED EMERGENCY ROOM AND CLINICALLY OUTCOME IN ACUTE THROMBOTIC STROKE PATIENTS","authors":"S. Rianawati, Habiba Aurora, Yulia Nugrahanitya","doi":"10.21776/UB.MNJ.2015.001.02.4","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.02.4","url":null,"abstract":"Background. High blood pressure is the first risk factor in stroke, but it is possible that low blood pressure causes stroke, although it is a few incident. Objective. To know the relation between blood pressure on arrival time in stroke unit and the clinical outcome of acute thrombolytic stroke patients using NIHSS score. Methods. Using cohort retrospective study, 38 samples were selected by consecutive method. The variable measured in this research is systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) at the first time in stroke unit to NIHSS patients in the last day nursing (10-14 days). Results. Based from Spearman correlation test, SBP (p = 0,136; r = 0,246), DBP (p = 0,586; r = 0,091), and MAP (p = 0,171; r = 0,227) indicate that have not significant correlation with NIHSS and indicate that very weak correlation. Conclusion. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) have not significant correlation with NIHSS and indicate that very weak correlation. Study is needed to understand the relation without any treatment influence and confounding factor.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"68-71"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68323513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-01DOI: 10.21776/UB.MNJ.2015.001.02.1
M. Husna, Kusworini Kusworini, Dian Wulansari
Background. Stroke is a local or extensive disorder of brain function that occurs suddenly and rapidly, can cause death without another cause except vascular. Based on pathophysiology of acute ischemic stroke, leukocytes play an important role against deterioration and clinical manifestations in patients by releasing three inflammatory mediators, plugging mechanism in microcirculation, and vasoconstriction. Objective. To investigate the relationship between the clinical manifestations of acute ischemic stroke (incoming, outgoing, and improvement) as measured by the NIHSS score with the number of leukocytes . Methods. The study design was a retrospective cohort sampling. Samples were taken from 62 patients with acute ischemic stroke (31 patients who have normal leukocytes and 31 patients who showed leukocytosis) in Dr. Saiful Anwar (RSSA) Malang hospital that met the inclusion criteria of the study. Results. The results of the statistical test used is Kolmogorov-Smirnov test for incoming NIHSS (p = 0.999), and Chi-Square Test for outcoming NIHSS (p = 0.000) and improved patient (p = 0.001). Conclusion. Patients who have normal leukocyte count at the beginning of treatment is likely to have clinical manifestations by category of incoming NIHSS similar to patients who showed leukocytosis, and tend to have clinical manifestations by category of outcoming NIHSS and improvement or significantly better than patients which showed leukocytosis.
{"title":"CORRELATION BETWEEN LEUKOCYTE COUNT WHEN ADMITTED IN EMERGENCY ROOM (ER) WITH CLINICALLY ACUTE ISCHEMIC STROKE PATIENTS","authors":"M. Husna, Kusworini Kusworini, Dian Wulansari","doi":"10.21776/UB.MNJ.2015.001.02.1","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.02.1","url":null,"abstract":"Background. Stroke is a local or extensive disorder of brain function that occurs suddenly and rapidly, can cause death without another cause except vascular. Based on pathophysiology of acute ischemic stroke, leukocytes play an important role against deterioration and clinical manifestations in patients by releasing three inflammatory mediators, plugging mechanism in microcirculation, and vasoconstriction. Objective. To investigate the relationship between the clinical manifestations of acute ischemic stroke (incoming, outgoing, and improvement) as measured by the NIHSS score with the number of leukocytes . Methods. The study design was a retrospective cohort sampling. Samples were taken from 62 patients with acute ischemic stroke (31 patients who have normal leukocytes and 31 patients who showed leukocytosis) in Dr. Saiful Anwar (RSSA) Malang hospital that met the inclusion criteria of the study. Results. The results of the statistical test used is Kolmogorov-Smirnov test for incoming NIHSS (p = 0.999), and Chi-Square Test for outcoming NIHSS (p = 0.000) and improved patient (p = 0.001). Conclusion. Patients who have normal leukocyte count at the beginning of treatment is likely to have clinical manifestations by category of incoming NIHSS similar to patients who showed leukocytosis, and tend to have clinical manifestations by category of outcoming NIHSS and improvement or significantly better than patients which showed leukocytosis.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68323270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-01DOI: 10.21776/UB.MNJ.2015.001.02.5
Ahmad Bayhaqi Nasir Alam, Masruroh Rahayu, Ahmad Zaki Sukma Islani
Background. The brain is an organ that has an important function potentially exposed to bad influences of radiation, especially on the head neck tumors. Gamma rays interact with body molecules causing damage to DNA and subsequently apoptosis. Caspase-3 plays an important role in apoptosis as effector caspase. Objective. To prove that the radiation of cobalt-60 gamma rays in Rattus norvegicus Wistar male variant causes brain cell apoptosis by the number of apoptotic cells more than in the single-dose fractionation. Methods. This Experimental research using animals were randomly divided into 3 groups: control, single and fractionation. Results. An increase in apoptotic index in the irradiated brain cells in single dose and fractionation dose compared by control group were significant (ANOVA, p > 0.05 ). Sequentially, the highest apoptotic index in a single group, fractionation, and control. Conclusion. The provision of radiation Cobalt - 60 gamma rays cause brain cell apoptosis Rattus norvegicus Wistar male variant and a single dose to cause apoptosis of brain cells more than the dose fractionation.
{"title":"EFFECT OF THE RADIATION OF GAMMA RAYS ON CASPASE-3 EXPRESSION IN RATTUS NORVEGICUS WISTAR MALE VARIANT BRAIN CELL WITH IMMUNOHISTOCHEMISTRY METHOD","authors":"Ahmad Bayhaqi Nasir Alam, Masruroh Rahayu, Ahmad Zaki Sukma Islani","doi":"10.21776/UB.MNJ.2015.001.02.5","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.02.5","url":null,"abstract":"Background. The brain is an organ that has an important function potentially exposed to bad influences of radiation, especially on the head neck tumors. Gamma rays interact with body molecules causing damage to DNA and subsequently apoptosis. Caspase-3 plays an important role in apoptosis as effector caspase. Objective. To prove that the radiation of cobalt-60 gamma rays in Rattus norvegicus Wistar male variant causes brain cell apoptosis by the number of apoptotic cells more than in the single-dose fractionation. Methods. This Experimental research using animals were randomly divided into 3 groups: control, single and fractionation. Results. An increase in apoptotic index in the irradiated brain cells in single dose and fractionation dose compared by control group were significant (ANOVA, p > 0.05 ). Sequentially, the highest apoptotic index in a single group, fractionation, and control. Conclusion. The provision of radiation Cobalt - 60 gamma rays cause brain cell apoptosis Rattus norvegicus Wistar male variant and a single dose to cause apoptosis of brain cells more than the dose fractionation.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"72-79"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-01DOI: 10.21776/UB.MNJ.2015.001.02.2
B. Munir, H. Rasyid, Rizky Rosita
Background. High blood glucose level occurs on 20-50% acute ischemic stroke patients. Hyperglycemia can worsen neurology disorder of patients. Objective. To find out the relationship between random blood glucose level and clinical outcome on patients with acute ischemic stroke measured with NIHSS. Methods. Observational using stroke registry of acute ischemic stroke patients. There are 38 patients involved in this research. Results. Using Spearman shows an insignificant correlation between random blood glucose level and NIHSS output (p=0.548). However, random blood glucose level and NIHSS input shows a significant correlation (p=0.011). The result of Chi-Square test on correlation between random blood glucose level and NIHSS output shows an insignificant correlation (p=1), in contrast, random blood glucose level and NIHSS input and improvement shows a significant correlation (p=0.024 and p=0.047). Conclusion. There is no correlation between random blood glucose level at initial care and clinical outcome on patients suffering acute ischemic stroke. However, normal random blood glucose level shows had better improvement and they had tendency to get better outcome.
{"title":"RELATIONSHIP BETWEEN THE RANDOM BLOOD GLUCOSE LEVELS DURING ADMISSION AT EMERGENCY ROOM WITH CLINICAL OUTPUT IN ACUTE ISCHEMIC STROKE PATIENTS","authors":"B. Munir, H. Rasyid, Rizky Rosita","doi":"10.21776/UB.MNJ.2015.001.02.2","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.02.2","url":null,"abstract":"Background. High blood glucose level occurs on 20-50% acute ischemic stroke patients. Hyperglycemia can worsen neurology disorder of patients. Objective. To find out the relationship between random blood glucose level and clinical outcome on patients with acute ischemic stroke measured with NIHSS. Methods. Observational using stroke registry of acute ischemic stroke patients. There are 38 patients involved in this research. Results. Using Spearman shows an insignificant correlation between random blood glucose level and NIHSS output (p=0.548). However, random blood glucose level and NIHSS input shows a significant correlation (p=0.011). The result of Chi-Square test on correlation between random blood glucose level and NIHSS output shows an insignificant correlation (p=1), in contrast, random blood glucose level and NIHSS input and improvement shows a significant correlation (p=0.024 and p=0.047). Conclusion. There is no correlation between random blood glucose level at initial care and clinical outcome on patients suffering acute ischemic stroke. However, normal random blood glucose level shows had better improvement and they had tendency to get better outcome.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"52-60"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68323335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-01DOI: 10.21776/UB.MNJ.2015.001.02.6
H. Hidayati
Atherosclerosis is a chronic, inflammatory disease of the arterial wall. Atherosclerosis underlies many of the common causes of cardiovascular morbidity and mortality, including myocardial infarction (MI), peripheral vascular disease, and cerebrovascular. Cardiovascular disease (CVD) has become the most frequent cause of death globally and then stroke is the second leading cause of death worldwide and a major cause of long-term disability. Recent study shows that adiponectin exhibits potent antiatherosclerotic effects. Adiponectin is a protein secreted specifically from adipose tissue. Adiponectin has a potential inhibitory effect on all molecular mechanisms of atherosclerosis.
{"title":"ANTI ATHEROSCLEROTIC EFFECT OF ADIPONECTIN","authors":"H. Hidayati","doi":"10.21776/UB.MNJ.2015.001.02.6","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.02.6","url":null,"abstract":"Atherosclerosis is a chronic, inflammatory disease of the arterial wall. Atherosclerosis underlies many of the common causes of cardiovascular morbidity and mortality, including myocardial infarction (MI), peripheral vascular disease, and cerebrovascular. Cardiovascular disease (CVD) has become the most frequent cause of death globally and then stroke is the second leading cause of death worldwide and a major cause of long-term disability. Recent study shows that adiponectin exhibits potent antiatherosclerotic effects. Adiponectin is a protein secreted specifically from adipose tissue. Adiponectin has a potential inhibitory effect on all molecular mechanisms of atherosclerosis.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.21776/UB.MNJ.2015.001.01.2
B. Munir, D. Candradikusuma
Background . Complications of HIV-AIDS cases neurological disorders are quite high and also very high mortality, but so far the data on disease epidemiology in Indonesia is still very limited. Objective. To determine the pattern of HIV-AIDS disease involving the nervous system in patients admitted to Saiful Anwar hospital. Methods . This prospective cohort study with a record of all patients with HIV-AIDS didagnosis manifest neurological disorders treated in an isolation room for HIV-AIDS Saiful Anwar Hospital for 1 year (September 2013- August 2014). Results . During 12 months acquired HIV-AIDS with neurological disorders as many as 23 patients (38.3% of all patients with an infection of the nervous system) with an average age of 48 years. Male gender 47.83%) and 52.17% of women. Number of CD4+ average of 24 / microliter, while the average number of leucocytes 9675/uL, while the most common sequence of disease; 39.1% of cerebral toxoplasmosis, tuberculosis meningoencephalitis 21.7%, 17.4% viral encephalitis, bacterial meningoencephalitis 13%, 4.3% dementia, cerebral abscess 4.3%. The mortality rate is still high, ranging from 57.6%. Conclusion . Manifestations of HIV AIDS in the field of neurology are very high, cerebral toxoplasmosis is the most common diagnosis, and correlated with the levels of CD4+. The mortality rate of HIV-AIDS cases manifesting high neurology.
{"title":"MANIFESTATIONS OF HIV AIDS IN CASE NEUROLOGY: EPIDEMIOLOGY STUDY AT SAIFUL ANWAR HOSPITAL YEAR 2013-2014","authors":"B. Munir, D. Candradikusuma","doi":"10.21776/UB.MNJ.2015.001.01.2","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.01.2","url":null,"abstract":"Background . Complications of HIV-AIDS cases neurological disorders are quite high and also very high mortality, but so far the data on disease epidemiology in Indonesia is still very limited. Objective. To determine the pattern of HIV-AIDS disease involving the nervous system in patients admitted to Saiful Anwar hospital. Methods . This prospective cohort study with a record of all patients with HIV-AIDS didagnosis manifest neurological disorders treated in an isolation room for HIV-AIDS Saiful Anwar Hospital for 1 year (September 2013- August 2014). Results . During 12 months acquired HIV-AIDS with neurological disorders as many as 23 patients (38.3% of all patients with an infection of the nervous system) with an average age of 48 years. Male gender 47.83%) and 52.17% of women. Number of CD4+ average of 24 / microliter, while the average number of leucocytes 9675/uL, while the most common sequence of disease; 39.1% of cerebral toxoplasmosis, tuberculosis meningoencephalitis 21.7%, 17.4% viral encephalitis, bacterial meningoencephalitis 13%, 4.3% dementia, cerebral abscess 4.3%. The mortality rate is still high, ranging from 57.6%. Conclusion . Manifestations of HIV AIDS in the field of neurology are very high, cerebral toxoplasmosis is the most common diagnosis, and correlated with the levels of CD4+. The mortality rate of HIV-AIDS cases manifesting high neurology.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68323197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.21776/UB.MNJ.2015.001.01.4
Masruroh Rahayu, S. Kurniawan, D. Anggraini
Background. Beta glucan from Saccharomyces cerevisae is very potential to be used as a regenerative therapy of Parkinson's disease. Beta glucan can increase the mobilization of hematopoietic stem cells (HSCs) from the bone marrow into the damaged tissues. Objective. To find out the effects of the addition of Saccharomyces cerevisae toward the number of brain cells in substantia nigra Parkinson’s rat model. Methods. Experimental research in vivo using the draft of randomized post test only controlled group design. Results. Treatment Group 3 (72 mg/kgBB) was a group with the largest number of brain cells than the other treatment groups. Statistical data obtained showed that the average number of brain cells in negative control group was 192.00 cells; positive control amounted to 116.80 cells; Treatment 1 amounted to 135.40 cells; Treatment 2 amounted to 140.80 cells; and Treatment 3 amounted to 161.80 cells. Conclusion. The addition of Saccharomyces cerevisae with a dose of 18mg/kgBB, 36mg/kgBBdan 72mg/kgBB is able to increase the number of brain cells in the substantia nigra of the brain of Parkinson’s Strain Wistar rat model significantly.
{"title":"THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE INCREASE OF THE NUMBER OF BRAIN CELLS IN SUBSTANTIA NIGRA BRAIN OF PARKINSON’S WISTAR STRAIN RAT (RATTUS NORVEGICUS) MODEL INDUCED WITH ROTENONE","authors":"Masruroh Rahayu, S. Kurniawan, D. Anggraini","doi":"10.21776/UB.MNJ.2015.001.01.4","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2015.001.01.4","url":null,"abstract":"Background. Beta glucan from Saccharomyces cerevisae is very potential to be used as a regenerative therapy of Parkinson's disease. Beta glucan can increase the mobilization of hematopoietic stem cells (HSCs) from the bone marrow into the damaged tissues. Objective. To find out the effects of the addition of Saccharomyces cerevisae toward the number of brain cells in substantia nigra Parkinson’s rat model. Methods. Experimental research in vivo using the draft of randomized post test only controlled group design. Results. Treatment Group 3 (72 mg/kgBB) was a group with the largest number of brain cells than the other treatment groups. Statistical data obtained showed that the average number of brain cells in negative control group was 192.00 cells; positive control amounted to 116.80 cells; Treatment 1 amounted to 135.40 cells; Treatment 2 amounted to 140.80 cells; and Treatment 3 amounted to 161.80 cells. Conclusion. The addition of Saccharomyces cerevisae with a dose of 18mg/kgBB, 36mg/kgBBdan 72mg/kgBB is able to increase the number of brain cells in the substantia nigra of the brain of Parkinson’s Strain Wistar rat model significantly.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68323373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.21776/UB.MNJ.2015.001.01.1
Herpan Syafii Harahap, S. Rianawati
Background. HIV/AIDS caused cellular immunodeficiency (the depletion of CD4+). This, in turn, raised many complications, such as HIV-associated dementia (HIV-D). Objective. To know the profile of cognitive function of patients of HIV/AIDS tretaed in Dr. Saiful Anwar Malang Hospital. Methods. This was a descriptive study using cross-sectional design. This study was conducted to 41 patients of HIV/AIDS treated in Dr. Saiful Anwar Malang Hospital during January to February 2012 (n=41). The cognitive function was assessed by using Mini Mental State Examination (MMSE) and Clock Drawing Test (CDT) instruments. Results. In MMSE, Number of patients showing total score 0-16 were 9 (21.95%), those showing total score 17-23 were 25 (60.98%), and those showing total score 24-30 were 7 (17.07%) . In CDT, 37 patients showed decrease of cognitive function (CDT<4), the remainder showed normal cognitive function. All of patients showing total score of both MMSE and CDT below normal limit, showed low level of CD4 (< 200 sel/µL). Patients showing normal cognitive function on CDT, also showing the same result on MMSE. Conclusion. Most of patients in this study showed the decrease of cognitive function.
背景。艾滋病毒/艾滋病引起细胞免疫缺陷(CD4+耗竭)。这反过来又引发了许多并发症，如艾滋病毒相关痴呆(HIV-D)。目标。了解在赛富·安华·玛琅医生医院接受治疗的HIV/AIDS患者的认知功能概况。方法。这是一项采用横断面设计的描述性研究。本研究对2012年1月至2月期间在Dr. Saiful Anwar Malang医院接受治疗的41名艾滋病毒/艾滋病患者进行了研究(n=41)。采用Mini Mental State Examination (MMSE)和Clock Drawing Test (CDT)评估认知功能。结果。在MMSE中，总分0 ~ 16分的有9例(21.95%)，总分17 ~ 23分的有25例(60.98%)，总分24 ~ 30分的有7例(17.07%)。CDT中，37例患者认知功能下降(CDT<4)，其余患者认知功能正常。MMSE和CDT总分均低于正常值的患者均表现为CD4低水平(< 200 sel/µL)。CDT显示认知功能正常的患者，MMSE也显示相同的结果。结论。本研究中大多数患者表现为认知功能下降。
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