Pub Date : 2020-06-24DOI: 10.21776/ub.mnj.2020.006.02.4
Gusti Agung Gede Ariswanda, I. Adnyana, I. Widyadharma, A. Nuartha, A. A. A. Putri, Laksmidewi, K. Arimbawa
Background: Stroke is affected by several factors, age, infection during treatment, obesity, and total cholesterol (TC) levels. Objective: The study aimed to prove low TC serum levels as an unfortunate outcome predictor for intracerebral hemorrhage stroke. Methods : This study is a prospective cohort design. The research did in the Stroke Unit of Sanglah Hospital, Denpasar, from July 1st, 2018 to January 31th, 2019. The study involved patients with hemorrhage strokes with low TC serum levels and aged 40-95 years. Depending on variable divided into two groups with low TC serum levels ( 180mg/dL). Independent variable is The National Institutes of Health Stroke Scale (NIHSS) as an outcome. The processing of data analysis using Mac for SPSS version 23. Result : This study used 70 subjects. The age characteristics of the study subjects with a median value of 62 years in for low TC levels, and 57 years for normal TC levels, dominant in male (60% ), working (71.5%), not obese (58.6%), stroke-related infections (51.4%), and mean arterial blood pressure (MABP) £130mmHg (90%). Subjects with low TC had a risk of 64 times experiencing adverse outcomes (RR = 64: CI 95% = 14.06-291.32: p <0.001). Multivariate analysis showed a low TC serum level as an independent variable. Conclusion : Low TC serum levels as an independent predictor having a poor outcome in intracerebral hemorrhage stroke
背景:中风受几个因素影响，年龄、治疗期间感染、肥胖和总胆固醇(TC)水平。目的:本研究旨在证明低TC血清水平是脑出血卒中的不幸预后预测因子。方法:本研究采用前瞻性队列设计。该研究于2018年7月1日至2019年1月31日在登巴萨Sanglah医院中风科进行。该研究涉及年龄在40-95岁之间的低TC血清水平的出血性中风患者。根据变量分为两组，均为低TC血清水平(180mg/dL)。独立变量是美国国立卫生研究院卒中量表(NIHSS)作为结果。数据分析的处理使用Mac为SPSS 23版。结果:本研究共纳入70名受试者。研究对象的年龄特征为低TC水平的中位值为62岁，TC水平正常的中位值为57岁，主要为男性(60%)，工作(71.5%)，非肥胖(58.6%)，卒中相关感染(51.4%)，平均动脉血压(MABP)£130mmHg(90%)。TC低的受试者出现不良结局的风险为64次(RR = 64: CI 95% = 14.06-291.32: p <0.001)。多因素分析显示血清TC水平低为自变量。结论:血清TC水平低是脑出血卒中预后不良的独立预测因子
{"title":"LOW TOTAL CHOLESTEROL SERUM LEVELS AS A POOR OUTCOME PREDICTOR FOR INTRA-CEREBRAL HEMORRHAGE STROKE","authors":"Gusti Agung Gede Ariswanda, I. Adnyana, I. Widyadharma, A. Nuartha, A. A. A. Putri, Laksmidewi, K. Arimbawa","doi":"10.21776/ub.mnj.2020.006.02.4","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.4","url":null,"abstract":"Background: Stroke is affected by several factors, age, infection during treatment, obesity, and total cholesterol (TC) levels. Objective: The study aimed to prove low TC serum levels as an unfortunate outcome predictor for intracerebral hemorrhage stroke. Methods : This study is a prospective cohort design. The research did in the Stroke Unit of Sanglah Hospital, Denpasar, from July 1st, 2018 to January 31th, 2019. The study involved patients with hemorrhage strokes with low TC serum levels and aged 40-95 years. Depending on variable divided into two groups with low TC serum levels ( 180mg/dL). Independent variable is The National Institutes of Health Stroke Scale (NIHSS) as an outcome. The processing of data analysis using Mac for SPSS version 23. Result : This study used 70 subjects. The age characteristics of the study subjects with a median value of 62 years in for low TC levels, and 57 years for normal TC levels, dominant in male (60% ), working (71.5%), not obese (58.6%), stroke-related infections (51.4%), and mean arterial blood pressure (MABP) £130mmHg (90%). Subjects with low TC had a risk of 64 times experiencing adverse outcomes (RR = 64: CI 95% = 14.06-291.32: p <0.001). Multivariate analysis showed a low TC serum level as an independent variable. Conclusion : Low TC serum levels as an independent predictor having a poor outcome in intracerebral hemorrhage stroke","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2020-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46530730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-23DOI: 10.21776/ub.mnj.2020.006.02.1
B. Munir, S. Rianawati, S. Kurniawan, W. M. Santoso, E. Arisetijono, D. Candradikusuma, Sutanto Heri, I. N. Chozin, Pratiwi Suryanti Dwi, Triwahju Astuti, Syaifullah Asmiragani
Background: Coronavirus disease 2019 (Covid-19) caused by SARS-Cov-2 had been spreading worldwide including Indonesia, but In Indonesia, it was difficult to diagnose confirmation Covid-19 by Polymerase Change Reaction (PCR). and in clinical practice to treat covid-19, Indonesia Health Ministry use term probable covid-19 for patients under observation Covid-19, but study for neurological manifestation on probable Covid-19 is very lacking. Objective: Knowing the neurological manifestation of patient probable Covid-19. Methods : Observational study from Covid-19 medical record and neuro-Covid-19 medical record of all probable Covid-19 hospitalized in the isolation ward of Saiful Anwar Hospital (RSSA) Malang since March-May, 2020 (3 months). Probable Covid-19 criteria were given by Covid-19 task force team based on Health Minister Indonesia criteria. This criterion was based on clinical manifestation (severe upper respiratory symptoms, or mild-severe pneumonia), radiologic examination (lung infiltrate and or chest CT scan), and laboratory examination. Neurological manifestation is based on clinical symptom appeared while patient hospitalized, supported with radiologic and laboratory data which was supervised by neurologist or neurologist resident. All data was inputted to neuro-Covid-19 e-registry on the smartphone application, sent periodically to the data center in Neurology Department RSSA Malang. Results: A hundred and fourteen probable Covid-19 was registered with mean age 34,5 year old and mostly at the young age of 20-50 years (38%). The neurological manifestation was observed in 4 patients (3,4% from all possible Covid-19 patients) with thrombotic stroke as the most common manifestation (50%), followed by myelum tumor (25%) and hypoxia encephalopathy (25%). Stroke patients in probable Covid-19 had old age (72 and 82 years) accompanied by several comorbid such as hypertension, DM and CVA history and Covid symptoms of cough, shortness of breath and fever. Hemiparesis was found improved with aspirin and neurotropic therapy. Patient with myelum tumor had a covid symptom of shortness of breath, cough, and fever with UMN tetraparesis. Previous MRI examination results suspected meningioma. The patient died while hospitalized. Patients with hypoxia encephalopathy admitted with decreased consciousness due to shortness of breath with acidosis respiratory symptoms (pH 7,22 ). This condition improved after oxygenation without focal neurologic deficit. Conclusion: Neurological manifestation in probable Covid-19 was 3,4% of all patients. The most common diagnosis was a thrombotic stroke, followed by myelum tumor, hypoxia encephalopathy, and mortality rate is 25%.
{"title":"NEUROLOGICAL MANIFESTATION ON HOSPITALIZED PATIENT WITH PROBABLE COVID-19 IN SAIFUL ANWAR HOSPITAL INDONESIA (SERIAL CASES)","authors":"B. Munir, S. Rianawati, S. Kurniawan, W. M. Santoso, E. Arisetijono, D. Candradikusuma, Sutanto Heri, I. N. Chozin, Pratiwi Suryanti Dwi, Triwahju Astuti, Syaifullah Asmiragani","doi":"10.21776/ub.mnj.2020.006.02.1","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.02.1","url":null,"abstract":"Background: Coronavirus disease 2019 (Covid-19) caused by SARS-Cov-2 had been spreading worldwide including Indonesia, but In Indonesia, it was difficult to diagnose confirmation Covid-19 by Polymerase Change Reaction (PCR). and in clinical practice to treat covid-19, Indonesia Health Ministry use term probable covid-19 for patients under observation Covid-19, but study for neurological manifestation on probable Covid-19 is very lacking. Objective: Knowing the neurological manifestation of patient probable Covid-19. Methods : Observational study from Covid-19 medical record and neuro-Covid-19 medical record of all probable Covid-19 hospitalized in the isolation ward of Saiful Anwar Hospital (RSSA) Malang since March-May, 2020 (3 months). Probable Covid-19 criteria were given by Covid-19 task force team based on Health Minister Indonesia criteria. This criterion was based on clinical manifestation (severe upper respiratory symptoms, or mild-severe pneumonia), radiologic examination (lung infiltrate and or chest CT scan), and laboratory examination. Neurological manifestation is based on clinical symptom appeared while patient hospitalized, supported with radiologic and laboratory data which was supervised by neurologist or neurologist resident. All data was inputted to neuro-Covid-19 e-registry on the smartphone application, sent periodically to the data center in Neurology Department RSSA Malang. Results: A hundred and fourteen probable Covid-19 was registered with mean age 34,5 year old and mostly at the young age of 20-50 years (38%). The neurological manifestation was observed in 4 patients (3,4% from all possible Covid-19 patients) with thrombotic stroke as the most common manifestation (50%), followed by myelum tumor (25%) and hypoxia encephalopathy (25%). Stroke patients in probable Covid-19 had old age (72 and 82 years) accompanied by several comorbid such as hypertension, DM and CVA history and Covid symptoms of cough, shortness of breath and fever. Hemiparesis was found improved with aspirin and neurotropic therapy. Patient with myelum tumor had a covid symptom of shortness of breath, cough, and fever with UMN tetraparesis. Previous MRI examination results suspected meningioma. The patient died while hospitalized. Patients with hypoxia encephalopathy admitted with decreased consciousness due to shortness of breath with acidosis respiratory symptoms (pH 7,22 ). This condition improved after oxygenation without focal neurologic deficit. Conclusion: Neurological manifestation in probable Covid-19 was 3,4% of all patients. The most common diagnosis was a thrombotic stroke, followed by myelum tumor, hypoxia encephalopathy, and mortality rate is 25%.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42261163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-30DOI: 10.21776/ub.mnj.2020.006.01.5
M. Ozdikici
Background : Numerous studies have been published on the anatomy and physiology of the corpus callosum (CC). There are many contradictory studies in the literature about the changes in the size of the CC by handedness, sex, and age. Objective : This study was carried out to examine the morphometric influence of these factors (handedness, sex, and age) on the CC in healthy Turkish adults Methods : Two hundred thirty-seven normal individuals, 101 males, and 136 females, divided into 5 age groups (20-29, 30-39, 40-49, 50-59, and 60-69) were subjected to magnetic resonance imaging (MRI) study of the brain. Of the 237 subjects, 27 males and 36 females were left-handed. Midsagittal corpus callosum area (CCA) was represented by the mean ± standard deviation of the age groups in square centimeters, and also comparisons of the right- and left-handed were also represented in Table 1. For statistical evaluation, the SPSS 15.0 was used. All statistical tests were set at a 95% confidence level (p 0.05) (Table 2). Conclusion: The results showed no statistical significance of the effect of age or handedness on the surface area of the CC. However, it was statistically significant that the size of men's CC was higher than that of women. Keywords: Midsagittal corpus callosum area, modified Cavalieri method, handedness, Turkish adults, magnetic resonance imaging.
{"title":"MEASUREMENT OF MIDSAGITTAL CORPUS CALLOSUM AREA WITH THE MODIFIED CAVALIERI METHOD IN HEALTHY RIGHT- AND LEFT-HANDED TURKISH ADULTS","authors":"M. Ozdikici","doi":"10.21776/ub.mnj.2020.006.01.5","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.01.5","url":null,"abstract":"Background : Numerous studies have been published on the anatomy and physiology of the corpus callosum (CC). There are many contradictory studies in the literature about the changes in the size of the CC by handedness, sex, and age. Objective : This study was carried out to examine the morphometric influence of these factors (handedness, sex, and age) on the CC in healthy Turkish adults Methods : Two hundred thirty-seven normal individuals, 101 males, and 136 females, divided into 5 age groups (20-29, 30-39, 40-49, 50-59, and 60-69) were subjected to magnetic resonance imaging (MRI) study of the brain. Of the 237 subjects, 27 males and 36 females were left-handed. Midsagittal corpus callosum area (CCA) was represented by the mean ± standard deviation of the age groups in square centimeters, and also comparisons of the right- and left-handed were also represented in Table 1. For statistical evaluation, the SPSS 15.0 was used. All statistical tests were set at a 95% confidence level (p 0.05) (Table 2). Conclusion: The results showed no statistical significance of the effect of age or handedness on the surface area of the CC. However, it was statistically significant that the size of men's CC was higher than that of women. Keywords: Midsagittal corpus callosum area, modified Cavalieri method, handedness, Turkish adults, magnetic resonance imaging.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47599912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-30DOI: 10.21776/ub.mnj.2020.006.01.3
Dewi Rachmawati, D. Ningsih, S. Andarini
Background The knowledge about stroke risks and early symptoms is pivotal to minimize the arrival delay in the hospital and maximize the effective treatments. Objective Investigating the factors affecting the knowledge about stroke risks and early symptoms in the emergency department (ED). Methods The study employed a cross-sectional design by means of a prospective approach. Samples were taken by consecutive sampling technique recruiting in a total of 58 respondents. The respondents were the family or relatives of acute ischemic stroke patients who happened to know and directly involved in taking the patients to the ED. Data analyzed by utilizing univariate analysis, independent t-test, and one-way ANOVA to determine the differences in the knowledge of every respondent based on several characteristics. Multivariate analysis was used to investigate the factors affecting the knowledge about stroke risks and early symptoms. Results The average age of the 58 respondents was 34 – 57 years old. 46.5% of whom were graduating from primary school; 51.7% have never been equipped with the necessary information about stroke; 55.2% are female, and 50% of whom were unemployed. There were differences in the knowledge about stroke risks based on the prior information about stroke and education background. As for stroke early symptoms, there were differences towards occupations, prior information about stroke, and education background. The most affecting factor towards the knowledge of stroke risks is education background (p=0.000); while the knowledge about stroke early symptoms were mostly affected by prior information about stroke (p=0.012) and education background (p=0.000). Discussions Most respondents were less equipped with the necessary knowledge about stroke risks and symptoms. The respondents’ knowledge about stroke risks and early symptoms was considered less, while education background was the affecting factor towards the knowledge about stroke risks and symptoms.
{"title":"FACTORS AFFECTING THE KNOWLEDGE ABOUT STROKE RISKS AND EARLY SYMPTOMS IN EMERGENCY DEPARTMENT EAST JAVA - INDONESIA","authors":"Dewi Rachmawati, D. Ningsih, S. Andarini","doi":"10.21776/ub.mnj.2020.006.01.3","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.01.3","url":null,"abstract":"Background The knowledge about stroke risks and early symptoms is pivotal to minimize the arrival delay in the hospital and maximize the effective treatments. Objective Investigating the factors affecting the knowledge about stroke risks and early symptoms in the emergency department (ED). Methods The study employed a cross-sectional design by means of a prospective approach. Samples were taken by consecutive sampling technique recruiting in a total of 58 respondents. The respondents were the family or relatives of acute ischemic stroke patients who happened to know and directly involved in taking the patients to the ED. Data analyzed by utilizing univariate analysis, independent t-test, and one-way ANOVA to determine the differences in the knowledge of every respondent based on several characteristics. Multivariate analysis was used to investigate the factors affecting the knowledge about stroke risks and early symptoms. Results The average age of the 58 respondents was 34 – 57 years old. 46.5% of whom were graduating from primary school; 51.7% have never been equipped with the necessary information about stroke; 55.2% are female, and 50% of whom were unemployed. There were differences in the knowledge about stroke risks based on the prior information about stroke and education background. As for stroke early symptoms, there were differences towards occupations, prior information about stroke, and education background. The most affecting factor towards the knowledge of stroke risks is education background (p=0.000); while the knowledge about stroke early symptoms were mostly affected by prior information about stroke (p=0.012) and education background (p=0.000). Discussions Most respondents were less equipped with the necessary knowledge about stroke risks and symptoms. The respondents’ knowledge about stroke risks and early symptoms was considered less, while education background was the affecting factor towards the knowledge about stroke risks and symptoms.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45308405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-30DOI: 10.21776/ub.mnj.2020.006.01.1
B. Munir, Firman Prayudi, C. Setianto, Siswanto
Background. The mortality rate of tuberculous meningitis (TBM) is approximately 20-41%. The prognosis is influenced by clinical and radiologic features, laboratory findings, and therapy. Objective. To report factors affecting the prognosis of TBM patients in Saiful Anwar Hospital. Methods. The study design was a retrospective cohort with consecutive sampling. Data were taken from medical records of 47 patients from 2016-2017. The prognostic value used modified rankin scale showing good (0-2) and poor prognosis (3-6). The impact of clinical, radiological, and laboratory factors were investigated by univariate analysis and multiple logistic regression. Results. In this study, good (n=21) and bad (n=26) prognosis were compared. Patients with good prognosis experienced more episodes of seizure than poor prognosis (17% vs 4%; p = 0.011). Focal neurologic deficits was more prevalent in poor prognosis (4% vs. 23%, p = 0.012). Meningeal enhancement was more common in poor prognosis (21% vs 42%; p= 0.038). From multivariate analysis, we found that seizure and focal neurological deficit are independent prognostic factors (p=0.023 dan p 0.033). Conclusion. Clinical factors influencing prognosis of TBM in Saiful Anwar Hospital are seizure and focal neurological deficit. Focal neurological deficit is a poor prognostic factor. However, seizure is a good prognostic factor. Keywords: prognostic factors, tuberculous meningitis
{"title":"FACTORS AFFECTING PROGNOSIS OF TUBERCULOUS MENINGITIS IN SAIFUL ANWAR GENERAL HOSPITAL MALANG","authors":"B. Munir, Firman Prayudi, C. Setianto, Siswanto","doi":"10.21776/ub.mnj.2020.006.01.1","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.01.1","url":null,"abstract":"Background. The mortality rate of tuberculous meningitis (TBM) is approximately 20-41%. The prognosis is influenced by clinical and radiologic features, laboratory findings, and therapy. Objective. To report factors affecting the prognosis of TBM patients in Saiful Anwar Hospital. Methods. The study design was a retrospective cohort with consecutive sampling. Data were taken from medical records of 47 patients from 2016-2017. The prognostic value used modified rankin scale showing good (0-2) and poor prognosis (3-6). The impact of clinical, radiological, and laboratory factors were investigated by univariate analysis and multiple logistic regression. Results. In this study, good (n=21) and bad (n=26) prognosis were compared. Patients with good prognosis experienced more episodes of seizure than poor prognosis (17% vs 4%; p = 0.011). Focal neurologic deficits was more prevalent in poor prognosis (4% vs. 23%, p = 0.012). Meningeal enhancement was more common in poor prognosis (21% vs 42%; p= 0.038). From multivariate analysis, we found that seizure and focal neurological deficit are independent prognostic factors (p=0.023 dan p 0.033). Conclusion. Clinical factors influencing prognosis of TBM in Saiful Anwar Hospital are seizure and focal neurological deficit. Focal neurological deficit is a poor prognostic factor. However, seizure is a good prognostic factor. Keywords: prognostic factors, tuberculous meningitis","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41486211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-30DOI: 10.21776/ub.mnj.2020.006.01.9
Iin Ernawati, H. Hidayati, Sumarno
Stroke is the second deadly disease in the world after ischemic heart disease. According to data of RISKESDAS ( Riset Kesehatan Dasar ), stroke was the highest cause of death in Indonesia in 2013. Hypertension is the one of the most important risk factors for stroke. Hypertension therapy is done by modification and the use of antihypertensives. The antihypertensives used is Telmisartan which is a class of Angiotensin Receptor Blocker (ARB) that works by inhibiting bind to angiotensin II type receptors that is angiotensin II type 1 receptors (AT-1R) which directly make angiotensin II bind to AT-2R (angiotensin receptor type 2 receptors). Telmisartan has a neuroprotectant effect that works by inhibiting the appearance of inflammatory cytokines, production of ROS (Reactive Oxygen Species), PGE2 (prostaglandin E2) and NMDA (N-Methyl-D-Aspartate) activity. Telmisartan activates PPAR-gamma (PPAR-γ), which is very useful in carbohydrate and lipid metabolism which directly protect blood vessels. Telmisartan has the advantage of structure and pharmacokinetics that support the effects of nerve protection. Based on lipophilicity and chemical structure, Telmisartan easily penetrates the brain barrier and high affinity to PPAR-γ, supporting the effects of Telmisartan neuroprotection. Based on pharmacokinetic aspects, telmisartan has the advantage of having a rapid onset that ranges from 30-60 minutes, with T ½ (half life) elimination is 24 hours. T 1/2 elimination for up to 24 hours from Telmisartan is clinically beneficial to improve medication adherence.
{"title":"THE EFFECTS NEUROPROTECTION OF TELMISARTAN ON STROKE WITH HYPERTENSION","authors":"Iin Ernawati, H. Hidayati, Sumarno","doi":"10.21776/ub.mnj.2020.006.01.9","DOIUrl":"https://doi.org/10.21776/ub.mnj.2020.006.01.9","url":null,"abstract":"Stroke is the second deadly disease in the world after ischemic heart disease. According to data of RISKESDAS ( Riset Kesehatan Dasar ), stroke was the highest cause of death in Indonesia in 2013. Hypertension is the one of the most important risk factors for stroke. Hypertension therapy is done by modification and the use of antihypertensives. The antihypertensives used is Telmisartan which is a class of Angiotensin Receptor Blocker (ARB) that works by inhibiting bind to angiotensin II type receptors that is angiotensin II type 1 receptors (AT-1R) which directly make angiotensin II bind to AT-2R (angiotensin receptor type 2 receptors). Telmisartan has a neuroprotectant effect that works by inhibiting the appearance of inflammatory cytokines, production of ROS (Reactive Oxygen Species), PGE2 (prostaglandin E2) and NMDA (N-Methyl-D-Aspartate) activity. Telmisartan activates PPAR-gamma (PPAR-γ), which is very useful in carbohydrate and lipid metabolism which directly protect blood vessels. Telmisartan has the advantage of structure and pharmacokinetics that support the effects of nerve protection. Based on lipophilicity and chemical structure, Telmisartan easily penetrates the brain barrier and high affinity to PPAR-γ, supporting the effects of Telmisartan neuroprotection. Based on pharmacokinetic aspects, telmisartan has the advantage of having a rapid onset that ranges from 30-60 minutes, with T ½ (half life) elimination is 24 hours. T 1/2 elimination for up to 24 hours from Telmisartan is clinically beneficial to improve medication adherence.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"6 1","pages":"41-46"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45713334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-02DOI: 10.21776/UB.MNJ.2018.004.01.6
V. Wiwanitkit
Cysticercosis is an important tropical parasitic worm infestation. This infection can result in cyst in any organs of human beings including to brain. The brain involvement of cysticercosis or neurocyticercosis is an important neurological infection that can cause serious neuruological problem. A good sanitation is the basic prevention for cysticercosis. Nevertheless, the hope is the use of vaccination. Here, the author briefly reviews and discusses on the present situation of neurocysticercosis vaccine.
{"title":"VACCINE FOR NEUROCYSTICERCOSIS: A PRESENT UPDATE","authors":"V. Wiwanitkit","doi":"10.21776/UB.MNJ.2018.004.01.6","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2018.004.01.6","url":null,"abstract":"Cysticercosis is an important tropical parasitic worm infestation. This infection can result in cyst in any organs of human beings including to brain. The brain involvement of cysticercosis or neurocyticercosis is an important neurological infection that can cause serious neuruological problem. A good sanitation is the basic prevention for cysticercosis. Nevertheless, the hope is the use of vaccination. Here, the author briefly reviews and discusses on the present situation of neurocysticercosis vaccine.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"4 1","pages":"35-37"},"PeriodicalIF":0.0,"publicationDate":"2018-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48219721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21776/UB.MNJ.2018.004.01.5
B. Purbasari, V. Anggraini, Made Dinda Pratiwi, M. Husna, S. Kurniawan
Background. The prevalence of diabetes mellitus has been epidemically increasing throughout all the world population, and diabetic polyneuropathy (PNP-DM) is one of the most common neurologic manifestation of this disease. Clinical research has proved that effective bedside screening of PNP-DM can significantly reduce the incidence of foot ulcer and limb amputation. Objective. To measure the diagnostic test of polyneuropathy scoring, monofilament 10-g SemmesWeinstein test, and 128 Hz tuning fork test as an early detection measure for PNP-DM. Methods. This research was conducted using a cross sectional approach from Januari 2016 to Juli 2017. Results. Among the total study population of 43 (23 men and 20 woman), Modified Toronto Score has the highest sensitivity (100%), PPV (93%) and accuracy (93%). Toronto score has the highest NPV (9%). Conclusion. Modified Toronto Score has good diagnostic value as screening tool in PNP-DM.
{"title":"DIAGNOSTIC TEST OF TORONTO AND MODIFIED TORONTO SCORING, MONOFILAMENT TEST, AND VIBRATE SENSATION TEST USING 128 HZ TUNING FORK FOR DIABETIC POLYNEUROPATHY","authors":"B. Purbasari, V. Anggraini, Made Dinda Pratiwi, M. Husna, S. Kurniawan","doi":"10.21776/UB.MNJ.2018.004.01.5","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2018.004.01.5","url":null,"abstract":"Background. The prevalence of diabetes mellitus has been epidemically increasing throughout all the world population, and diabetic polyneuropathy (PNP-DM) is one of the most common neurologic manifestation of this disease. Clinical research has proved that effective bedside screening of PNP-DM can significantly reduce the incidence of foot ulcer and limb amputation. Objective. To measure the diagnostic test of polyneuropathy scoring, monofilament 10-g SemmesWeinstein test, and 128 Hz tuning fork test as an early detection measure for PNP-DM. Methods. This research was conducted using a cross sectional approach from Januari 2016 to Juli 2017. Results. Among the total study population of 43 (23 men and 20 woman), Modified Toronto Score has the highest sensitivity (100%), PPV (93%) and accuracy (93%). Toronto score has the highest NPV (9%). Conclusion. Modified Toronto Score has good diagnostic value as screening tool in PNP-DM.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"4 1","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21776/UB.MNJ.2018.004.01.1
Qisthinadia Hazhiyah Setiadi, Herpan Syafii Harahap, Y. Indrayana
Background. Stroke is the third cause of death worldwide. Ischemic stroke is the most common type of stroke with high prevalence. Obesity is one of ischemic stroke risk factor, but its correlation with higher ischemic stroke risk remains unclear. Studies about correlation of waist hip ratio (WHR) and ischemic stroke risk is still contradictive. Objective. This study was aimed to explore the correlation between WHR and ischemic stroke probability. Methods. This was a descriptive analytic study using cross sectional design. The population of this study was resident in Sekarbela Mataram aged 55-84 years old. This study was conducted 63 participants. They were interviewed and received a measurement of WHR and ischemic stroke probability. The ischemic stroke probability was assessed by using assessment of Framingham stroke risk score. Data were analyzed by using Pearson correlation. Results. Among 63 participants, 51 (81%) were abdominal obesity and 12 (19%) were normal based on WHR measurement. Pearson correlation analysis showed that there was no correlation between WHR and ischemic stroke probability (p = 0,11). Conclusion. There was no correlation between WHR and ischemic stroke probability of population in Sekarbela Mataram
{"title":"THE CORRELATION OF WAIST HIP RATIO TO ISCHEMIC STROKE PROBABILITY OF POPULATION IN SEKARBELA MATARAM","authors":"Qisthinadia Hazhiyah Setiadi, Herpan Syafii Harahap, Y. Indrayana","doi":"10.21776/UB.MNJ.2018.004.01.1","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2018.004.01.1","url":null,"abstract":"Background. Stroke is the third cause of death worldwide. Ischemic stroke is the most common type of stroke with high prevalence. Obesity is one of ischemic stroke risk factor, but its correlation with higher ischemic stroke risk remains unclear. Studies about correlation of waist hip ratio (WHR) and ischemic stroke risk is still contradictive. Objective. This study was aimed to explore the correlation between WHR and ischemic stroke probability. Methods. This was a descriptive analytic study using cross sectional design. The population of this study was resident in Sekarbela Mataram aged 55-84 years old. This study was conducted 63 participants. They were interviewed and received a measurement of WHR and ischemic stroke probability. The ischemic stroke probability was assessed by using assessment of Framingham stroke risk score. Data were analyzed by using Pearson correlation. Results. Among 63 participants, 51 (81%) were abdominal obesity and 12 (19%) were normal based on WHR measurement. Pearson correlation analysis showed that there was no correlation between WHR and ischemic stroke probability (p = 0,11). Conclusion. There was no correlation between WHR and ischemic stroke probability of population in Sekarbela Mataram","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"4 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.21776/UB.MNJ.2018.004.01.3
Indriati Dwi Rahayu, O. Paundralingga, Vidia Sari
Background. The safety of genistein consumption in the first trimester of pregnancy and its effect on embryonic development, especially in the development of Central Nervous System (CNS) is still not widely known. Objective. To determine the effect of genistein exposure to the early development of the Central Nervous System. Methods. The animal model used in this research is chick embryo (Gallus gallus). Genistein at a dose of 5 µM, 10 µM and 20 µM in ovo injected into the yolk sac of the eggs before incubation. The eggs were then incubated for 48 hours at a temperature of from 37.50 to 38.50 C. After 48 hours, broken egg shell, embryos are taken and carried out using Toluidine Blue staining. The evaluation was done on the neural tube, anterior neuropore, posterior neuropore and somites. Results. It was found neural tube defects in the group treated with genistein more than the control group but the result was not statistically significant. Conclusion. For the somites, in the group treated with a dose of 10 µM genistein, the number of somites more than the control group and statistically the number is significant.
{"title":"EFFECTS OF GENISTEIN EXPOSURE TOWARD INITIAL DEVELOPMENT OF CENTRAL NERVOUS SYSTEM IN CHICKEN EMBRYO MODEL (GALLUS GALLUS) AGE 48 HOURS","authors":"Indriati Dwi Rahayu, O. Paundralingga, Vidia Sari","doi":"10.21776/UB.MNJ.2018.004.01.3","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2018.004.01.3","url":null,"abstract":"Background. The safety of genistein consumption in the first trimester of pregnancy and its effect on embryonic development, especially in the development of Central Nervous System (CNS) is still not widely known. Objective. To determine the effect of genistein exposure to the early development of the Central Nervous System. Methods. The animal model used in this research is chick embryo (Gallus gallus). Genistein at a dose of 5 µM, 10 µM and 20 µM in ovo injected into the yolk sac of the eggs before incubation. The eggs were then incubated for 48 hours at a temperature of from 37.50 to 38.50 C. After 48 hours, broken egg shell, embryos are taken and carried out using Toluidine Blue staining. The evaluation was done on the neural tube, anterior neuropore, posterior neuropore and somites. Results. It was found neural tube defects in the group treated with genistein more than the control group but the result was not statistically significant. Conclusion. For the somites, in the group treated with a dose of 10 µM genistein, the number of somites more than the control group and statistically the number is significant.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"209 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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