Yasmine A. Deiaeldin, Mona Mohammad Elsharkawy, Hadeel M. Abdelrahman, Khadija Alforjani Abdulhadi Omar, Mohammed A Al-Naimy
Nephrotic syndrome (NS) is by far, the most common glomerular disease in childhood period and is considered as one of the main aetiologies of child exposure to systemic steroids. High-dose corticosteroids for NS, are usually prescribed by pediatrians for a long period. Posterior subcapsular cataract (PSC) and increased intraocular pressure (IOP) are the two most common ocular complications associated with steroid treatment. The exact incidence, prevalence, severity, and time of cataract and glaucoma onset in those childrens have not yet been thoroughly investigated. Evaluating the incidence of cataract and glaucoma in children with NS receiving steroid treatment during and after treatment cessation. This cohort prospective study was done at the Pediatric Nephrology Clinic at Zagazig University Children’s Hospital in co-operation with the Department of Ophthalmology, Zagazig University, for detailed eye examination. Totally 48 children with primary NS who received corticosteroids either as a single treatment or with other treatment modalities for more than 3 months were included in our study. Clinical features plus laboratory tests confirmed by renal biopsy were the main parameters used in the diagnosis of NS. Posterior subcapsular cataracts (PSC) were observed in 14 patients (29.2%). All studied patients had normal intraocular pressure ranging between 10 and 20 mmHg in both eyes during the follow-up period with no glaucomatous optic disc changes observed. A significant number of children with NS treated with steroids are liable to develop cataracts and glaucoma that may progress and need surgery to preserve vision, so they have to be well diagnosed and followed-up.
{"title":"Incidence of cataract and glaucoma in children with nephrotic syndrome undergoing steroid treatment","authors":"Yasmine A. Deiaeldin, Mona Mohammad Elsharkawy, Hadeel M. Abdelrahman, Khadija Alforjani Abdulhadi Omar, Mohammed A Al-Naimy","doi":"10.4103/ejos.ejos_68_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_68_23","url":null,"abstract":"Nephrotic syndrome (NS) is by far, the most common glomerular disease in childhood period and is considered as one of the main aetiologies of child exposure to systemic steroids. High-dose corticosteroids for NS, are usually prescribed by pediatrians for a long period. Posterior subcapsular cataract (PSC) and increased intraocular pressure (IOP) are the two most common ocular complications associated with steroid treatment. The exact incidence, prevalence, severity, and time of cataract and glaucoma onset in those childrens have not yet been thoroughly investigated. Evaluating the incidence of cataract and glaucoma in children with NS receiving steroid treatment during and after treatment cessation. This cohort prospective study was done at the Pediatric Nephrology Clinic at Zagazig University Children’s Hospital in co-operation with the Department of Ophthalmology, Zagazig University, for detailed eye examination. Totally 48 children with primary NS who received corticosteroids either as a single treatment or with other treatment modalities for more than 3 months were included in our study. Clinical features plus laboratory tests confirmed by renal biopsy were the main parameters used in the diagnosis of NS. Posterior subcapsular cataracts (PSC) were observed in 14 patients (29.2%). All studied patients had normal intraocular pressure ranging between 10 and 20 mmHg in both eyes during the follow-up period with no glaucomatous optic disc changes observed. A significant number of children with NS treated with steroids are liable to develop cataracts and glaucoma that may progress and need surgery to preserve vision, so they have to be well diagnosed and followed-up.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Megha Kotecha, Aman Khanna, Varsha Manade, Jhimli Ta, Surbhi A. Chodvadiya
To evaluate the functional visual recovery following phacoemulsification cataract surgery with foldable intraocular lens implantation through a temporal clear corneal incision. This prospective study was conducted at a tertiary health care centre in Western Maharashtra over a period of 2 years. Detailed history was taken and thorough ocular examination of was done. Visual Acuity, Color vision, Contrast sensitivity, Binocular vision was noted. Visual Fields were examined and Glare Disability was assessed. All patients underwent temporal clear corneal Phacoemulsification surgery through a 3.2 mm incision with implantation of an Aspheric Monofocal Foldable IOL under LA. All patients were started on tapering dose of antibiotic − steroid over 6 weeks and followed up post operatively on day 1, week 1, week 2, 6 weeks, 3months and at 6 months. 50 eyes of 46 patients with immature cataract aged between 40 to 80 years were included. At the end of 24 weeks the Distance Vision was ≥ 6/9 in 31 eyes, 6/18–6/12 in 17 eyes and < 6/18 in 2 eyes. It was a statistically significant difference (P<0.0001). No significant difference in near vision was seen at the end of 6 months. The difference in astigmatism post operatively in all 50 eyes was not statistically significant at the end of 6 months (P<0.05). Significant improvement in contrast sensitivity was seen post operatively (P<0.0001). The mean glare disability was 14.06 s at 24 weeks. No significant difference was seen (P>0.05). Colour vision and Field of vision were similar postoperatively. All the patients maintained grade 3 binocular vision at end of the study. Phacoemulsification with monofocal foldable intraocular lenses can be the choice of technique in treatment of cataract as being able to provide excellent visual results and also being cost effective.
{"title":"Clinical study of functional visual recovery following phacoemulsification with IOL implantation","authors":"Megha Kotecha, Aman Khanna, Varsha Manade, Jhimli Ta, Surbhi A. Chodvadiya","doi":"10.4103/ejos.ejos_60_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_60_23","url":null,"abstract":"To evaluate the functional visual recovery following phacoemulsification cataract surgery with foldable intraocular lens implantation through a temporal clear corneal incision. This prospective study was conducted at a tertiary health care centre in Western Maharashtra over a period of 2 years. Detailed history was taken and thorough ocular examination of was done. Visual Acuity, Color vision, Contrast sensitivity, Binocular vision was noted. Visual Fields were examined and Glare Disability was assessed. All patients underwent temporal clear corneal Phacoemulsification surgery through a 3.2 mm incision with implantation of an Aspheric Monofocal Foldable IOL under LA. All patients were started on tapering dose of antibiotic − steroid over 6 weeks and followed up post operatively on day 1, week 1, week 2, 6 weeks, 3months and at 6 months. 50 eyes of 46 patients with immature cataract aged between 40 to 80 years were included. At the end of 24 weeks the Distance Vision was ≥ 6/9 in 31 eyes, 6/18–6/12 in 17 eyes and < 6/18 in 2 eyes. It was a statistically significant difference (P<0.0001). No significant difference in near vision was seen at the end of 6 months. The difference in astigmatism post operatively in all 50 eyes was not statistically significant at the end of 6 months (P<0.05). Significant improvement in contrast sensitivity was seen post operatively (P<0.0001). The mean glare disability was 14.06 s at 24 weeks. No significant difference was seen (P>0.05). Colour vision and Field of vision were similar postoperatively. All the patients maintained grade 3 binocular vision at end of the study. Phacoemulsification with monofocal foldable intraocular lenses can be the choice of technique in treatment of cataract as being able to provide excellent visual results and also being cost effective.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"38 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nada M.Y. El Adawy, Yasser S. Mohamed, Noha M. Khalil, Yasmine M. Elsayed, Mohamed B. Kenawy
The aim of this study was to compare 2% dorzolamide/0.5% timolol fixed combination brand name drug (Cosopt) to its generic counterpart (Twinzol) regarding efficacy and side effects. The study included 92 eyes of 92 patients diagnosed with primary open-angle glaucoma and are indicated for antiglaucoma fixed combination of 20 mg/ml dorzolamide/5 mg/ml timolol). Patients were randomly divided into two groups: the first group received Cosopt, whereas the second received Twinzol. In visit, intraocular pressure (IOP) was measured and any local side effects by either eye drops was recorded. Monitoring and recording the percentage of IOP drop each month and all over the 3 months duration of follow up visits were done. The percentage of IOP drop for Cosopt and Twinzol after 1 month showed a significant P value of 0.032, with a mean percent reduction in IOP of 28.55%, median percent reduction of 26.92%, the minimum is 3.82% while the maximum is 62.96% for the Cosopt group, while that for Twinzol was 23.14, 21.29, 4.17, and 57.14%, respectively. On the other hand, the percentage of drop of IOP between the two groups after 3 months showed insignificant P value (0.646). IOP measurement was statistically insignificant between the two groups at 1 (0.462) and 3 months (0.639). As regards side effects; both eye drops were comparable with an insignificant P value of 0.49. The study demonstrated a reliable efficacy and safety on using generic therapy Twinzol compared with band counterpart Cosopt.
{"title":"A comparison between 2% dorzolamide/0.5% timolol fixed combination: brand name drug to its generic counterpart regarding efficacy and side effects","authors":"Nada M.Y. El Adawy, Yasser S. Mohamed, Noha M. Khalil, Yasmine M. Elsayed, Mohamed B. Kenawy","doi":"10.4103/ejos.ejos_33_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_33_23","url":null,"abstract":"The aim of this study was to compare 2% dorzolamide/0.5% timolol fixed combination brand name drug (Cosopt) to its generic counterpart (Twinzol) regarding efficacy and side effects. The study included 92 eyes of 92 patients diagnosed with primary open-angle glaucoma and are indicated for antiglaucoma fixed combination of 20 mg/ml dorzolamide/5 mg/ml timolol). Patients were randomly divided into two groups: the first group received Cosopt, whereas the second received Twinzol. In visit, intraocular pressure (IOP) was measured and any local side effects by either eye drops was recorded. Monitoring and recording the percentage of IOP drop each month and all over the 3 months duration of follow up visits were done. The percentage of IOP drop for Cosopt and Twinzol after 1 month showed a significant P value of 0.032, with a mean percent reduction in IOP of 28.55%, median percent reduction of 26.92%, the minimum is 3.82% while the maximum is 62.96% for the Cosopt group, while that for Twinzol was 23.14, 21.29, 4.17, and 57.14%, respectively. On the other hand, the percentage of drop of IOP between the two groups after 3 months showed insignificant P value (0.646). IOP measurement was statistically insignificant between the two groups at 1 (0.462) and 3 months (0.639). As regards side effects; both eye drops were comparable with an insignificant P value of 0.49. The study demonstrated a reliable efficacy and safety on using generic therapy Twinzol compared with band counterpart Cosopt.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"66 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To study the difference between the intended skin incision size at the start of the surgery in Ex-DCR and the actual final intraoperative incision size after its closure at the end of the surgery, and to look for a correlation between this difference and the patient’s age, gender and side of surgery. A prospective Observational case series study was performed on 50 patients with unilateral nasolacrimal duct obstruction. The incision will be measured in millimeters using a caliper. The incision size was measured again after wound closure at the end of the surgery in millimeters. The difference between both sizes was correlated to the age, gender and side of surgery. The mean age of the patients was 45.6±16.6 years. Twenty-nine were females (58%). There was a statistically significant increase in the mean incision size at the end of the surgery (10.5±0.6 vs. 12.9±1.3 mm). This change was related to female gender, age above 50 years of age and procedures done on the left side. Size of skin incision increases inevitably at the end of the surgery. The amount of increase is related to age, sex and side of the procedure.
{"title":"Difference between skin incision size at the start and at the end of external dacryocystorhinostomy","authors":"Karim Bakr, Jylan Gouda, Alia Nour Eldin","doi":"10.4103/ejos.ejos_43_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_43_23","url":null,"abstract":"To study the difference between the intended skin incision size at the start of the surgery in Ex-DCR and the actual final intraoperative incision size after its closure at the end of the surgery, and to look for a correlation between this difference and the patient’s age, gender and side of surgery. A prospective Observational case series study was performed on 50 patients with unilateral nasolacrimal duct obstruction. The incision will be measured in millimeters using a caliper. The incision size was measured again after wound closure at the end of the surgery in millimeters. The difference between both sizes was correlated to the age, gender and side of surgery. The mean age of the patients was 45.6±16.6 years. Twenty-nine were females (58%). There was a statistically significant increase in the mean incision size at the end of the surgery (10.5±0.6 vs. 12.9±1.3 mm). This change was related to female gender, age above 50 years of age and procedures done on the left side. Size of skin incision increases inevitably at the end of the surgery. The amount of increase is related to age, sex and side of the procedure.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"36 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Achondroplasia, an autosomal dominant congenital enchondral ossification, is clinically characterized by short stature, craniofacial, and bone deformities. Ophthalmic features include telecanthus and strabismus; cone-rod dystrophy can also be present. A 12-year-old male presented with decreased vision bilaterally, nystagmus, and achondroplasia. The best corrected visual acuity (BCVA) was Log MAR 1.0 in the right eye and Log MAR 0.8 in the left eye, the anterior segments showed no abnormalities, however the fundus showed bilateral macular coloboma. On electrophysiological assessment, there was also bilateral cone-rod dysfunction. As ophthalmic associations are common in Achondroplasia, thorough ophthalmological examination as well as electrophysiological assessment are mandatory.
软骨发育不全症（Achondroplasia）是一种常染色体显性遗传的先天性软骨骨化症，临床特征为身材矮小、颅面部和骨骼畸形。眼部特征包括远视和斜视，也可能出现锥杆营养不良。一名 12 岁的男性患者出现双侧视力下降、眼球震颤和软骨发育不全。右眼最佳矫正视力（BCVA）为Log MAR 1.0，左眼为Log MAR 0.8，眼前节未见异常，但眼底显示双侧黄斑部巨瘤。在电生理评估中，双侧视锥杆也出现了功能障碍。由于软骨发育不全常见眼部病变，因此必须进行全面的眼科检查和电生理评估。
{"title":"Achondroplasia with macular coloboma and cone-rod dystrophy: a case report","authors":"Randa M. A. M. El-Mofty, Mai M. I. Hassan","doi":"10.4103/ejos.ejos_61_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_61_23","url":null,"abstract":"Achondroplasia, an autosomal dominant congenital enchondral ossification, is clinically characterized by short stature, craniofacial, and bone deformities. Ophthalmic features include telecanthus and strabismus; cone-rod dystrophy can also be present. A 12-year-old male presented with decreased vision bilaterally, nystagmus, and achondroplasia. The best corrected visual acuity (BCVA) was Log MAR 1.0 in the right eye and Log MAR 0.8 in the left eye, the anterior segments showed no abnormalities, however the fundus showed bilateral macular coloboma. On electrophysiological assessment, there was also bilateral cone-rod dysfunction. As ophthalmic associations are common in Achondroplasia, thorough ophthalmological examination as well as electrophysiological assessment are mandatory.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"154 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nazanin Amini, K. Rezaei, A. Moslemi, Mehdi Harorani, H. Modir
The aim of this study was to compare the effects of vitamin A ointment and Liposic gel on perioperative corneal abrasion (CA) prevention during nonocular surgeries. A double-blind randomized clinical trial. In this double-blind randomized clinical trial 50 eligible candidates for nonocular surgeries were purposively selected from XXX teaching hospital, XXX. One patient eye was randomly allocated to the vitamin A group and the other eye to the Liposic gel group. Immediately after anesthesia induction and blinking reflex suppression, eye care was provided using vitamin A ointment in the vitamin A group and Liposic gel in the Liposic gel group. CA was assessed using the fluorescein eye stain test at the end of general anesthesia, at the end of postoperative recovery, and 24 h after surgery. Eye problems were also assessed 24 h after surgery using an eye problems questionnaire. The SPSS software (v. 23.0) was employed for data analysis through the Wilcoxon’s, paired-sample t, and Friedman’s tests as well as the repeated measures analysis of variance. The prevalence of CA in the vitamin A and the Liposic gel groups was 32 and 50% at the end of general anesthesia (P=0.039), 32 and 52% at the end of postoperative recovery (P = 0.018), and 0 and 0% 24 h after surgery (P = 1.00), respectively. There were no significant between-group differences respecting postoperative eye problems (P > 0.05). Vitamin A ointment is more effective than Liposic gel in significantly preventing CA among patients undergoing non-ocular surgeries under general anesthesia.
本研究旨在比较维生素 A 软膏和 Liposic 凝胶在非眼科手术围手术期预防角膜擦伤（CA）的效果。 双盲随机临床试验。 在这项双盲随机临床试验中，特意从 XXX 教学医院挑选了 50 名符合条件的非眼科手术候选者。患者的一只眼睛被随机分配到维生素 A 组，另一只眼睛被随机分配到脂溶性凝胶组。在麻醉诱导和眨眼反射抑制后，维生素 A 组立即使用维生素 A 软膏，脂溶性凝胶组立即使用脂溶性凝胶进行眼部护理。在全身麻醉结束时、术后恢复结束时和术后 24 小时内，使用荧光素眼部染色试验对 CA 进行评估。术后 24 小时后，还使用眼部问题问卷对眼部问题进行了评估。数据分析采用 SPSS 软件（23.0 版），通过 Wilcoxon 检验、配对样本 t 检验、Friedman 检验和重复测量方差分析进行。 维生素 A 组和脂溶性凝胶组在全身麻醉结束时的 CA 患病率分别为 32% 和 50%（P=0.039），术后恢复结束时分别为 32% 和 52%（P=0.018），术后 24 小时分别为 0% 和 0%（P=1.00）。在术后眼部问题方面，组间差异不明显（P > 0.05）。 在全身麻醉下接受非眼科手术的患者中，维生素 A 软膏在显著预防 CA 方面比 Liposic 凝胶更有效。
{"title":"Comparing the effects of vitamin A ointment and liposic gel on corneal abrasion prevention during general anesthesia in nonocular surgeries: a double-blind randomized clinical trial","authors":"Nazanin Amini, K. Rezaei, A. Moslemi, Mehdi Harorani, H. Modir","doi":"10.4103/ejos.ejos_47_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_47_23","url":null,"abstract":"The aim of this study was to compare the effects of vitamin A ointment and Liposic gel on perioperative corneal abrasion (CA) prevention during nonocular surgeries. A double-blind randomized clinical trial. In this double-blind randomized clinical trial 50 eligible candidates for nonocular surgeries were purposively selected from XXX teaching hospital, XXX. One patient eye was randomly allocated to the vitamin A group and the other eye to the Liposic gel group. Immediately after anesthesia induction and blinking reflex suppression, eye care was provided using vitamin A ointment in the vitamin A group and Liposic gel in the Liposic gel group. CA was assessed using the fluorescein eye stain test at the end of general anesthesia, at the end of postoperative recovery, and 24 h after surgery. Eye problems were also assessed 24 h after surgery using an eye problems questionnaire. The SPSS software (v. 23.0) was employed for data analysis through the Wilcoxon’s, paired-sample t, and Friedman’s tests as well as the repeated measures analysis of variance. The prevalence of CA in the vitamin A and the Liposic gel groups was 32 and 50% at the end of general anesthesia (P=0.039), 32 and 52% at the end of postoperative recovery (P = 0.018), and 0 and 0% 24 h after surgery (P = 1.00), respectively. There were no significant between-group differences respecting postoperative eye problems (P > 0.05). Vitamin A ointment is more effective than Liposic gel in significantly preventing CA among patients undergoing non-ocular surgeries under general anesthesia.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"105 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nehal Alaaeldin Abdeltawab, R. Allam, S. Salah, Nahla Borhan, Shaimaa Arfeen
Evaluation of macular vascular density and sensitivity using optical coherence tomography angiography (OCT-A), and 10-2 perimetry in patients having rheumatoid arthritis (RA) and receiving hydroxychloroquine (HCQ) treatment for more than 5 years in comparison to RA patients not receiving HCQ. A cross-sectional case-control study. The study included 52 eyes (52 patients) divided into 2 equal groups. Macular vascular density and sensitivity were evaluated in both groups using OCT-A and 10-2 perimetry. Field defects were significantly detected in the Lower Nasal (LN) and Upper Temporal (UT) quadrants in the HCQ group as compared to the non-HCQ group (P values=0.012 and 0.010, respectively). The vascular density decreased significantly in the Central Temporal (CT) quadrant of the superficial plexus in the HCQ group (P value 0.041). There was a significant positive correlation between vascular density and visual acuity in the CT quadrant of the deep plexus in HCQ group (P value: 0.047). In the HCQ group, the scotomata in the UT, LN, and central quadrants of the visual field were associated with significant decrease in vascular density of the corresponding LN, UT, and CT quadrants of the deep plexus respectively (P value<0.05). In the non-HCQ group, the scotomata in the LN quadrant of the visual field were associated with significant decrease in the vascular density of the corresponding UT quadrant of the deep vascular plexus. HCQ induced vascular changes are quite low and the microvascular changes in RA patients on HCQ treatment are related to the disease pathology rather than the treatment itself.
{"title":"Evaluation of macular sensitivity and vascular density in patients having rheumatoid arthritis on hydroxychloroquine treatment","authors":"Nehal Alaaeldin Abdeltawab, R. Allam, S. Salah, Nahla Borhan, Shaimaa Arfeen","doi":"10.4103/ejos.ejos_44_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_44_23","url":null,"abstract":"Evaluation of macular vascular density and sensitivity using optical coherence tomography angiography (OCT-A), and 10-2 perimetry in patients having rheumatoid arthritis (RA) and receiving hydroxychloroquine (HCQ) treatment for more than 5 years in comparison to RA patients not receiving HCQ. A cross-sectional case-control study. The study included 52 eyes (52 patients) divided into 2 equal groups. Macular vascular density and sensitivity were evaluated in both groups using OCT-A and 10-2 perimetry. Field defects were significantly detected in the Lower Nasal (LN) and Upper Temporal (UT) quadrants in the HCQ group as compared to the non-HCQ group (P values=0.012 and 0.010, respectively). The vascular density decreased significantly in the Central Temporal (CT) quadrant of the superficial plexus in the HCQ group (P value 0.041). There was a significant positive correlation between vascular density and visual acuity in the CT quadrant of the deep plexus in HCQ group (P value: 0.047). In the HCQ group, the scotomata in the UT, LN, and central quadrants of the visual field were associated with significant decrease in vascular density of the corresponding LN, UT, and CT quadrants of the deep plexus respectively (P value<0.05). In the non-HCQ group, the scotomata in the LN quadrant of the visual field were associated with significant decrease in the vascular density of the corresponding UT quadrant of the deep vascular plexus. HCQ induced vascular changes are quite low and the microvascular changes in RA patients on HCQ treatment are related to the disease pathology rather than the treatment itself.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"3 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139329684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamdy El Gazzar, Mohamed Masoud, Alyaa Wagih, Soha Moussa Al-Tohamy
Keratoconus (KC) is a noninflammatory disease causing anatomical deformity of the cornea and is manifested by marked conical protrusion in addition to thinning of the corneal central part. There are currently no standardized screening criteria for KC, making early diagnosis difficult. Early diagnosis aids in stopping progression and better management. It has been proposed that spectral domain optical coherence tomography (SD-OCT) has a diagnostic advantage in the early detection of corneal thickness changes in early KC. Detection of corneal epithelial thickness changes in early KC eyes versus normal eyes using SD-OCT. The research involved 30 eyes with early KC and 30 eyes from healthy control patients. Both groups underwent detailed ophthalmological examination and measurement of regional corneal epithelial thickness with anterior segment SD-OCT. In the cases group, corneal epithelium thickness decreased significantly in all regions tested. Additionally, all parameters of the pentacam pachymetry indices showed a statistically significant increase in the cases group. All of the thinnest pachymetry at central 5 mm and 7 mm Area Under the Curve (AUC=0.822 and 0.804), the location Y at central 5 mm and 7 mm (AUC=0.796 and 0.738), the minimum-maximum at central 5 mm and 7 mm (AUC=0.878 and 0.934), and the standard of deviation at central 5 mm and 7 mm (AUC=0.935 and 0.941) showed a statistically significant predictive value for differentiation KC cases from control (P < 0.001), with the highest AUC reported with the standard of deviation. The tested corneal thickness in various regions correlated positively and statistically significantly with pentacam pachymetry indices. Early KC is associated with corneal thinning and increased pentacam pachymetry index parameters. The changes detected by pentacam pachymetry and epithelial thickness as detected by SD-OCT showed a significant correlation.
{"title":"Corneal epithelial thickness mapping by optical coherence tomography in normal and early keratoconic eyes","authors":"Hamdy El Gazzar, Mohamed Masoud, Alyaa Wagih, Soha Moussa Al-Tohamy","doi":"10.4103/ejos.ejos_45_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_45_23","url":null,"abstract":"Keratoconus (KC) is a noninflammatory disease causing anatomical deformity of the cornea and is manifested by marked conical protrusion in addition to thinning of the corneal central part. There are currently no standardized screening criteria for KC, making early diagnosis difficult. Early diagnosis aids in stopping progression and better management. It has been proposed that spectral domain optical coherence tomography (SD-OCT) has a diagnostic advantage in the early detection of corneal thickness changes in early KC. Detection of corneal epithelial thickness changes in early KC eyes versus normal eyes using SD-OCT. The research involved 30 eyes with early KC and 30 eyes from healthy control patients. Both groups underwent detailed ophthalmological examination and measurement of regional corneal epithelial thickness with anterior segment SD-OCT. In the cases group, corneal epithelium thickness decreased significantly in all regions tested. Additionally, all parameters of the pentacam pachymetry indices showed a statistically significant increase in the cases group. All of the thinnest pachymetry at central 5 mm and 7 mm Area Under the Curve (AUC=0.822 and 0.804), the location Y at central 5 mm and 7 mm (AUC=0.796 and 0.738), the minimum-maximum at central 5 mm and 7 mm (AUC=0.878 and 0.934), and the standard of deviation at central 5 mm and 7 mm (AUC=0.935 and 0.941) showed a statistically significant predictive value for differentiation KC cases from control (P < 0.001), with the highest AUC reported with the standard of deviation. The tested corneal thickness in various regions correlated positively and statistically significantly with pentacam pachymetry indices. Early KC is associated with corneal thinning and increased pentacam pachymetry index parameters. The changes detected by pentacam pachymetry and epithelial thickness as detected by SD-OCT showed a significant correlation.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"185 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yomna M. Ismail, Magda A. Aal, Walid H. Attia, Ahmed Hassanin
To detect corneal structural changes in people who have recovered from COVID-19 infection by specular microscopy and anterior segment optical coherence tomography (AS-OCT). Moreover, the study compares corneal endothelial and structural parameters between those who have recovered from COVID-19 and individuals who have neither been infected nor vaccinated. This is a prospective observational case–control comparative study involving 108 eyes from 54 individuals. The participants are divided into two groups: the case group (individuals recovered from COVID-19 infection) with 54 eyes (27 individuals) and the control group (individuals with no history of COVID-19 infection or vaccination) with 54 eyes (27 individuals). Both groups are matched for age and sex. The study involves architectural analysis of the cornea using anterior segment OCT and evaluation of the corneal endothelium using specular microscopy. The case group’s mean cell density (CD) was 2445.5±310.6 cells/mm, while the control group was 2689.6±398.7 cells/mm (P value 0.001). This indicates a statistically significant decrease in CD among individuals in the case group compared with the control group. The case group’s mean cell area (SD) standard deviation was 169.6±115.2. In contrast, in the control group, it was 135.87±39.29 (P value 0.004), signifying a statistically significant increase in the case group. There was also a statistically significant increase in the average cell area (AVE) in the case group compared with the control group (P value 0.024). However, there were no statistically significant differences in other specular parameters, such as coefficient of variation (CV) or 6A or in the pachymetry. Similarly, no statistically significant differences in AS-OCT parameters were observed between both groups. The study reveals a decrease in corneal endothelial cell count and an increase in the average cell area among individuals who have recovered from COVID-19 during their recovery period. However, it is noteworthy that the specular microscopy parameters remained within the clinically normal range for both groups, and visual acuity was unaffected.
{"title":"Evaluation of corneal structural changes in post-COVID-19 patients using anterior segment optical coherence tomography and specular microscopy","authors":"Yomna M. Ismail, Magda A. Aal, Walid H. Attia, Ahmed Hassanin","doi":"10.4103/ejos.ejos_48_23","DOIUrl":"https://doi.org/10.4103/ejos.ejos_48_23","url":null,"abstract":"To detect corneal structural changes in people who have recovered from COVID-19 infection by specular microscopy and anterior segment optical coherence tomography (AS-OCT). Moreover, the study compares corneal endothelial and structural parameters between those who have recovered from COVID-19 and individuals who have neither been infected nor vaccinated. This is a prospective observational case–control comparative study involving 108 eyes from 54 individuals. The participants are divided into two groups: the case group (individuals recovered from COVID-19 infection) with 54 eyes (27 individuals) and the control group (individuals with no history of COVID-19 infection or vaccination) with 54 eyes (27 individuals). Both groups are matched for age and sex. The study involves architectural analysis of the cornea using anterior segment OCT and evaluation of the corneal endothelium using specular microscopy. The case group’s mean cell density (CD) was 2445.5±310.6 cells/mm, while the control group was 2689.6±398.7 cells/mm (P value 0.001). This indicates a statistically significant decrease in CD among individuals in the case group compared with the control group. The case group’s mean cell area (SD) standard deviation was 169.6±115.2. In contrast, in the control group, it was 135.87±39.29 (P value 0.004), signifying a statistically significant increase in the case group. There was also a statistically significant increase in the average cell area (AVE) in the case group compared with the control group (P value 0.024). However, there were no statistically significant differences in other specular parameters, such as coefficient of variation (CV) or 6A or in the pachymetry. Similarly, no statistically significant differences in AS-OCT parameters were observed between both groups. The study reveals a decrease in corneal endothelial cell count and an increase in the average cell area among individuals who have recovered from COVID-19 during their recovery period. However, it is noteworthy that the specular microscopy parameters remained within the clinically normal range for both groups, and visual acuity was unaffected.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"324 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139330379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Elashri, Amany Ghazy, Nesma Elkemary, Nashwa Sadik, Ahmed Eissa
Objective Despite the application of aseptic protocols and the technical improvements of intraocular surgery, acute endophthalmitis is still noticed after cataract surgery. Presurgical prophylaxis was suggested to reduce the incidence of postcataract endophthalmitis. However, there is no clear protocol to follow. Aim The current study aimed to investigate the effect of preoperative topical antibiotics on anterior segment contamination in patients with cataract after phacoemulsification or phacotrabeculectomy. Patients, methods, and analysis The study enrolled 55 patients who underwent phacoemulsification or phacotrabeculectomy and intraocular lens implantation; 28 patients have used preoperative antibiotic drops (moxifloxacin 0.3%), and 27 patients did not use antibiotics. Anterior chamber (AC) aspirates were collected to determine the anterior segment microbial profile using microscopic examination and microbial cultures. Results All AC aspirates (100%) of the first group did not show any microbial growth on any culture media. However, bacterial growth was noted in three (11.1%) aspirates of the second group when cultured on blood, chocolate agar, and thioglycolate broth. Microscopic examination revealed Klebsiella pneumoniae, Escherichia coli, and Bacillus subtilis. All aspirates did not show any growth on Sabouraud dextrose agar. All patients were followed up after 1 day, 1 week, 1 month, and 3 months. Their ophthalmologic examinations were free of any abnormities. Conclusion Despite taking all the precautionary measures dictated by best practice guidelines for cataract surgery, there is minimal risk of AC bacterial contamination. Thus, the application of preoperative topical antibiotic drops is recommended for all cases.
{"title":"Studying the effect of preoperative topical antibiotic drops on anterior chamber contamination after phacoemulsification","authors":"Mohammed Elashri, Amany Ghazy, Nesma Elkemary, Nashwa Sadik, Ahmed Eissa","doi":"10.4103/ejos.ejos_85_22","DOIUrl":"https://doi.org/10.4103/ejos.ejos_85_22","url":null,"abstract":"Objective Despite the application of aseptic protocols and the technical improvements of intraocular surgery, acute endophthalmitis is still noticed after cataract surgery. Presurgical prophylaxis was suggested to reduce the incidence of postcataract endophthalmitis. However, there is no clear protocol to follow. Aim The current study aimed to investigate the effect of preoperative topical antibiotics on anterior segment contamination in patients with cataract after phacoemulsification or phacotrabeculectomy. Patients, methods, and analysis The study enrolled 55 patients who underwent phacoemulsification or phacotrabeculectomy and intraocular lens implantation; 28 patients have used preoperative antibiotic drops (moxifloxacin 0.3%), and 27 patients did not use antibiotics. Anterior chamber (AC) aspirates were collected to determine the anterior segment microbial profile using microscopic examination and microbial cultures. Results All AC aspirates (100%) of the first group did not show any microbial growth on any culture media. However, bacterial growth was noted in three (11.1%) aspirates of the second group when cultured on blood, chocolate agar, and thioglycolate broth. Microscopic examination revealed Klebsiella pneumoniae, Escherichia coli, and Bacillus subtilis. All aspirates did not show any growth on Sabouraud dextrose agar. All patients were followed up after 1 day, 1 week, 1 month, and 3 months. Their ophthalmologic examinations were free of any abnormities. Conclusion Despite taking all the precautionary measures dictated by best practice guidelines for cataract surgery, there is minimal risk of AC bacterial contamination. Thus, the application of preoperative topical antibiotic drops is recommended for all cases.","PeriodicalId":31572,"journal":{"name":"Journal of the Egyptian Ophthalmological Society","volume":"29 1","pages":"131 - 137"},"PeriodicalIF":0.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：