A. H. Aalami, A. Amirabadi, Fatemeh Hosseini Mojahed, Ali Ayatllahi
Myxofibrosarcoma is a soft tissue sarcoma (STS) prevailing in the elderly and is associated with metastasis and mortality. In this case, an 88-year-old male is presented with a progressively enlarging mass in the posterior thorax. The physical examination revealed a solid, irregular, painful mass on palpation. Doppler ultrasonography and high-resolution computed tomography (CT) scan revealed a 60 × 38 mm hypoechoic tumor in the left paraspinal thoracic area with a little vascularity with no adherence and invasion. Radical excisional surgery was performed. The histopathology findings were in line with myxofibrosarcoma except for CD34. He underwent high dose radiotherapy due to the reported not assessable margins at one side. The patient was asymptomatic and recurrent free in the 12 months follow up assessment. It was the first known case of the non-metastatic intermediate grade of myxofibrosarcoma in the thorax. Due to its deceptive findings, myxofibrosarcoma should always be considered in the assessment of chest wall tumors.
{"title":"Description and management of non-metastatic thoracic myxofibrosarcoma: a case report","authors":"A. H. Aalami, A. Amirabadi, Fatemeh Hosseini Mojahed, Ali Ayatllahi","doi":"10.34172/JSUMS.2020.24","DOIUrl":"https://doi.org/10.34172/JSUMS.2020.24","url":null,"abstract":"Myxofibrosarcoma is a soft tissue sarcoma (STS) prevailing in the elderly and is associated with metastasis and mortality. In this case, an 88-year-old male is presented with a progressively enlarging mass in the posterior thorax. The physical examination revealed a solid, irregular, painful mass on palpation. Doppler ultrasonography and high-resolution computed tomography (CT) scan revealed a 60 × 38 mm hypoechoic tumor in the left paraspinal thoracic area with a little vascularity with no adherence and invasion. Radical excisional surgery was performed. The histopathology findings were in line with myxofibrosarcoma except for CD34. He underwent high dose radiotherapy due to the reported not assessable margins at one side. The patient was asymptomatic and recurrent free in the 12 months follow up assessment. It was the first known case of the non-metastatic intermediate grade of myxofibrosarcoma in the thorax. Due to its deceptive findings, myxofibrosarcoma should always be considered in the assessment of chest wall tumors.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129533996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Hakimi, Elham Zarean, M. Nikfarjam, P. Yarmohammadi
Background and aims: Music therapy is a simple and inexpensive method for the treatment of some psychiatric disorders. The aim of this study was to determine the effect of traditional music on the mental state of hospitalized chronic schizophrenia patients. Methods: In this clinical trial, 30 schizophrenia patients in the intervention group received routine treatment and attended music therapy sessions and 30 patients in the control group received routine treatment alone. Group music therapy sessions with traditional music were conducted 5 times a week for 2 months. Demographic questionnaire and Andreasen’s positive and negative symptoms questionnaires were completed at baseline and after the completion of music therapy sessions. Data analysis was conducted in SPSS version 16.0 using independent and paired t tests. Results: The mean scores of delusion (P=0.001) and bizarre behavior (P=0.036) and the total score of the SAPS (P=0.001) significantly decreased after intervention in the music therapy group. However, in the control group, the differences in the total and individual domain scores of the SAPS were not significant (P>0.05). There was no significant difference between the control and music therapy groups in the total and individual domain scores of the Scale for the Assessment of Negative Symptoms (SANS) before and after the intervention (P>0.05). Additionally, before and after the study, the mean score of avolition in the music therapy group was significantly lower compared to the control group (P=0.03). The mean score of alogia in the music therapy group was significantly lower compared to the control group (P=0.01). Conclusion: Music therapy is effective in improving most of the positive symptoms of schizophrenia and some of its negative aspects, and therefore can be used as a complementary therapy along with drug therapy.
{"title":"The effect of traditional music on mental status of chronic schizophrenic patients: a clinical trial study","authors":"F. Hakimi, Elham Zarean, M. Nikfarjam, P. Yarmohammadi","doi":"10.34172/JSUMS.2020.22","DOIUrl":"https://doi.org/10.34172/JSUMS.2020.22","url":null,"abstract":"Background and aims: Music therapy is a simple and inexpensive method for the treatment of some psychiatric disorders. The aim of this study was to determine the effect of traditional music on the mental state of hospitalized chronic schizophrenia patients. Methods: In this clinical trial, 30 schizophrenia patients in the intervention group received routine treatment and attended music therapy sessions and 30 patients in the control group received routine treatment alone. Group music therapy sessions with traditional music were conducted 5 times a week for 2 months. Demographic questionnaire and Andreasen’s positive and negative symptoms questionnaires were completed at baseline and after the completion of music therapy sessions. Data analysis was conducted in SPSS version 16.0 using independent and paired t tests. Results: The mean scores of delusion (P=0.001) and bizarre behavior (P=0.036) and the total score of the SAPS (P=0.001) significantly decreased after intervention in the music therapy group. However, in the control group, the differences in the total and individual domain scores of the SAPS were not significant (P>0.05). There was no significant difference between the control and music therapy groups in the total and individual domain scores of the Scale for the Assessment of Negative Symptoms (SANS) before and after the intervention (P>0.05). Additionally, before and after the study, the mean score of avolition in the music therapy group was significantly lower compared to the control group (P=0.03). The mean score of alogia in the music therapy group was significantly lower compared to the control group (P=0.01). Conclusion: Music therapy is effective in improving most of the positive symptoms of schizophrenia and some of its negative aspects, and therefore can be used as a complementary therapy along with drug therapy.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116530072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Exercise training is a well-established therapeutic tool for treating type 2 diabetes. The purpose of this study is to examine the beneficial effects of personalized sprint interval training (SIT) and combined aerobic endurance and resistance training (Com) on insulin resistance and glycated hemoglobin A1c (HbA1c) concentration in women with type 2 diabetes. Methods: Fifty-two overweight female type 2 diabetic patients (age 45-60 years and body mass index [BMI] > 30) with HbA1c value of 6.5% or higher and fasting blood glucose (FBG) ≥ 126 mg/dL (7.0 mmol/L) were selected. Participants were recruited from patients filed in the outpatient department of Shahrekord Hospital (Shahrekord, Iran) in 2016. The participants were assigned to SIT (n=17), Com (n=17), and control groups (n=18) according to HbA1c levels. The exercises included 10 weeks of Com and SIT. Results: HbA1c concentrations decreased significantly in SIT (P=0.002) and Com (P=0.006) groups. The dependent t-test revealed that differences were significant for the FBG in the SIT groups (P<0.001). Serum insulin levels showed significant increases in the SIT (P<0.001) and Com (P<0.001) groups. Data showed significant differences in homeostasis model assessment-estimated insulin resistance (HOMA-IR) in SIT (P<0.001) and Com (P<0.001) groups. The analysis of covariance (ANCOVA) test showed significant differences in serum insulin (F=3.622, P=0.02) and HOMA-IR (F=5.511, P=0.0001) levels and no significant difference in HbA1c (F=0.597, P=0.556) and FBG concentrations (F=1.853, P=0.171). Conclusion: Results highlight that individualized exercise training, independent of the mode of training, is effective in improving glycemic control in overweight patients with type 2 diabetes.
{"title":"The effects of personalized sprint interval training and combined aerobic endurance and resistance training on insulin resistance and glycated hemoglobin in women with type 2 diabetes","authors":"H. Ghaedi, Siamak Takesh, E. Banitalebi","doi":"10.34172/JSUMS.2020.18","DOIUrl":"https://doi.org/10.34172/JSUMS.2020.18","url":null,"abstract":"Background and aims: Exercise training is a well-established therapeutic tool for treating type 2 diabetes. The purpose of this study is to examine the beneficial effects of personalized sprint interval training (SIT) and combined aerobic endurance and resistance training (Com) on insulin resistance and glycated hemoglobin A1c (HbA1c) concentration in women with type 2 diabetes. Methods: Fifty-two overweight female type 2 diabetic patients (age 45-60 years and body mass index [BMI] > 30) with HbA1c value of 6.5% or higher and fasting blood glucose (FBG) ≥ 126 mg/dL (7.0 mmol/L) were selected. Participants were recruited from patients filed in the outpatient department of Shahrekord Hospital (Shahrekord, Iran) in 2016. The participants were assigned to SIT (n=17), Com (n=17), and control groups (n=18) according to HbA1c levels. The exercises included 10 weeks of Com and SIT. Results: HbA1c concentrations decreased significantly in SIT (P=0.002) and Com (P=0.006) groups. The dependent t-test revealed that differences were significant for the FBG in the SIT groups (P<0.001). Serum insulin levels showed significant increases in the SIT (P<0.001) and Com (P<0.001) groups. Data showed significant differences in homeostasis model assessment-estimated insulin resistance (HOMA-IR) in SIT (P<0.001) and Com (P<0.001) groups. The analysis of covariance (ANCOVA) test showed significant differences in serum insulin (F=3.622, P=0.02) and HOMA-IR (F=5.511, P=0.0001) levels and no significant difference in HbA1c (F=0.597, P=0.556) and FBG concentrations (F=1.853, P=0.171). Conclusion: Results highlight that individualized exercise training, independent of the mode of training, is effective in improving glycemic control in overweight patients with type 2 diabetes.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131573800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Parastesh, E. Alibakhshi, A. Saremi, N. Shavandi
Background and aims: It has recently been documented that obesity is a global problem in all age groups, so that it affects about 250 million people in the world, accounting for 7% of the world’s population. Adipose tissue has an important role in inducing lung dysfunction through production and secretion of adipokines such as leptin. The aim of this study was to investigate the effect of a period of aerobic training on lung function indices and serum leptin levels in obese men. Methods: A total of 23 untrained obese men in Arak were recruited voluntarily for the study and randomly assigned to obese aerobic training group (Ob-AT, n=12) (45.26±2.45 years, body mass index (BMI) of 31.81±0.77 kg/m2 ) and obese control group (Ob-Cnt, n=11) (47.03±3.36 years, BMI of 31.45±0.96 kg/m2). Another normal control group (No-Cnt, n = 9) was sampled from individuals with normal weight to compare at the base level (45.1±4.1 years, BMI of 24.63±0.45 kg/m2 ). The obese exercise group participated in 12 weeks of progressive aerobic training, 3 sessions a week, 1.5 hours per session. Body composition (CT scan), leptin levels and lung function were measured before and after exercise protocol. Results: The participants with normal weight had significantly lower leptin concentration (P=0.01) and a higher lung function (P=0.016) compared to the obese participants. Moreover, the results indicated that leptin and obesity had an inverse correlation with lung function indices (forced vital capacity [FVC] and forced expiratory volume in one second [FEV1 ]) (P≤0.05). After the aerobic activity, obesity (BMI, WHR, body fat) and lung function indices (FVC and FEV1 ) significantly decreased in the obese aerobic training group compared to the obese control group (P≤0.05). In contrast, leptin concentration significantly decreased after the aerobic exercise protocol (P=0.018). Conclusion: We found that leptin level decreased after 12 weeks of aerobic exercise in obese men and this decrease was associated with the increased lung function and profound changes in body fat. The obtained data suggest that 12-week aerobic exercise causes alterations in leptin level that plays a key role in improving lung function.
{"title":"The effect of aerobic exercise training on leptin and pulmonary function tests during weight loss in men with visceral obesity","authors":"M. Parastesh, E. Alibakhshi, A. Saremi, N. Shavandi","doi":"10.34172/jsums.2020.15","DOIUrl":"https://doi.org/10.34172/jsums.2020.15","url":null,"abstract":"\u0000 Background and aims: It has recently been documented that obesity is a global problem in all age groups, so that it affects about 250 million people in the world, accounting for 7% of the world’s population. Adipose tissue has an important role in inducing lung dysfunction through production and secretion of adipokines such as leptin. The aim of this study was to investigate the effect of a period of aerobic training on lung function indices and serum leptin levels in obese men. Methods: A total of 23 untrained obese men in Arak were recruited voluntarily for the study and randomly assigned to obese aerobic training group (Ob-AT, n=12) (45.26±2.45 years, body mass index (BMI) of 31.81±0.77 kg/m2 ) and obese control group (Ob-Cnt, n=11) (47.03±3.36 years, BMI of 31.45±0.96 kg/m2). Another normal control group (No-Cnt, n = 9) was sampled from individuals with normal weight to compare at the base level (45.1±4.1 years, BMI of 24.63±0.45 kg/m2 ). The obese exercise group participated in 12 weeks of progressive aerobic training, 3 sessions a week, 1.5 hours per session. Body composition (CT scan), leptin levels and lung function were measured before and after exercise protocol. Results: The participants with normal weight had significantly lower leptin concentration (P=0.01) and a higher lung function (P=0.016) compared to the obese participants. Moreover, the results indicated that leptin and obesity had an inverse correlation with lung function indices (forced vital capacity [FVC] and forced expiratory volume in one second [FEV1 ]) (P≤0.05). After the aerobic activity, obesity (BMI, WHR, body fat) and lung function indices (FVC and FEV1 ) significantly decreased in the obese aerobic training group compared to the obese control group (P≤0.05). In contrast, leptin concentration significantly decreased after the aerobic exercise protocol (P=0.018). Conclusion: We found that leptin level decreased after 12 weeks of aerobic exercise in obese men and this decrease was associated with the increased lung function and profound changes in body fat. The obtained data suggest that 12-week aerobic exercise causes alterations in leptin level that plays a key role in improving lung function.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126991023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kamali, M. Arian, Parisa Arashnia, Z. Amini, Mostafa Roshanravan
Dehydration and malignancies are known as the most frequent predisposing factors of cerebral venous sinus thrombosis in older adults despite the fact that 30% of them remain idiopathic cerebral venous thrombosis (CVT) cases with no clear etiology. Cases of left sigmoid sinus involvement were rarely reported. Herein, an elderly case of sigmoid sinus thrombosis with unilateral hearing loss with chronic varicose vein in the leg was reported. Sigmoid sinus thrombosis that affects hearing is one of the rare complications of otitis media. Whether or not a large chronic varicose vein in the leg can serve as a predisposing factor for CVT requires further studies. Successful management of anticoagulant therapy prevented serious complications in the patient
{"title":"Sigmoid sinus thrombosis in an elderly client with chronic varicose vein in the leg: a case report","authors":"A. Kamali, M. Arian, Parisa Arashnia, Z. Amini, Mostafa Roshanravan","doi":"10.34172/jsums.2020.16","DOIUrl":"https://doi.org/10.34172/jsums.2020.16","url":null,"abstract":"Dehydration and malignancies are known as the most frequent predisposing factors of cerebral venous sinus thrombosis in older adults despite the fact that 30% of them remain idiopathic cerebral venous thrombosis (CVT) cases with no clear etiology. Cases of left sigmoid sinus involvement were rarely reported. Herein, an elderly case of sigmoid sinus thrombosis with unilateral hearing loss with chronic varicose vein in the leg was reported. Sigmoid sinus thrombosis that affects hearing is one of the rare complications of otitis media. Whether or not a large chronic varicose vein in the leg can serve as a predisposing factor for CVT requires further studies. Successful management of anticoagulant therapy prevented serious complications in the patient","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126358810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Nosrati, M. Zarei, I. Salehi, S. Soleimani asl, A. Komaki, S. Moradkhani
Background and aimsThe cardiac angiogenesis is one of the complications of diabetes. The oxidative stress occurs when there is an imbalance between the production of free radicals and antioxidant defense of the body. In diabetes mellitus, hyperglycemia induces increased oxidative stress through biological processes. Diabetes is also associated with reduced antioxidant defense by reducing glutathione, catalase, and superoxide dismutase. Rosa damascena Millhas antioxidant properties. This study aimed to investigate the effects of hydroalcoholic extract of R. damascena Millon cardiac angiogenesis in diabetic rats.MethodsInthis experimental study carried out in 2016, a total of 48 adult male Wistar rats (190-200 g) were randomly divided into 8 groups (n = 6) including control, extracts (200, 400, and 1000 mg/kg), diabetic, and diabetic plus extracts (200, 400, and 1000 mg/kg). Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ) (50 mg/kg) and the rats were gavaged with different doses of extract for 30 days. At the end of the treatment, serum levels of vascular endothelial growth factor (VEGF) were determined by enzyme-linked immunosorbent assay and the rat hearts were removed for immunohistochemistry study.ResultsThe treatment with hydroalcoholic extract of R. damascene Mill had no significant effect on cardiac capillary density [F (7, 40) = 0.5, P > 0.05] and the serum levels of VEGF [F (7, 40) = 0.406, P > 0.05]. However, there was no significant difference in blood glucose level in extract groups compared to control rats as well as diabetic plus extract groups compared to diabetic rats [F (7,40) = 0.787, P > 0.05].ConclusionAccording to our results, the hydroalcoholic extract of R. damascene Mill had no effect on cardiac angiogenesis in the normal and diabetic subjects. These findings were probably due to the insufficient amounts of effective ingredients, especially flavonoids, in this plant, or the duration of extract administration.
背景与目的心脏血管生成是糖尿病的并发症之一。当自由基的产生和身体的抗氧化防御之间存在不平衡时，就会发生氧化应激。在糖尿病中，高血糖通过生物过程诱导氧化应激增加。糖尿病还通过减少谷胱甘肽、过氧化氢酶和超氧化物歧化酶来降低抗氧化防御能力。大马士革玫瑰具有抗氧化性能。本研究旨在探讨大黄水醇提取物对糖尿病大鼠心脏血管生成的影响。方法2016年选取成年雄性Wistar大鼠48只(190 ~ 200 g)，随机分为对照组、提取物(200、400、1000 mg/kg)、糖尿病组、糖尿病加提取物(200、400、1000 mg/kg) 8组(n = 6)。采用腹腔注射链脲佐菌素(STZ) (50 mg/kg)诱导糖尿病大鼠，灌胃不同剂量的链脲佐菌素提取物30 d。治疗结束时，采用酶联免疫吸附法测定血清血管内皮生长因子(VEGF)水平，并取大鼠心脏进行免疫组化研究。结果丹参水醇提取物对大鼠心肌毛细血管密度(F (7,40) = 0.5, P > 0.05)及血清VEGF水平(F (7,40) = 0.406, P > 0.05)无显著影响。而提取物组的血糖水平与对照大鼠、糖尿病+提取物组的血糖水平与糖尿病大鼠相比无显著差异[F (7,40) = 0.787, P > 0.05]。结论丹参水醇提取物对正常和糖尿病人心脏血管生成无明显影响。这些发现可能是由于这种植物中有效成分，特别是黄酮类化合物的含量不足，或者是提取物的使用时间过长。
{"title":"Effects of hydroalcoholic extract of Rosa damascena Mill on the cardiac angiogenesis in diabetic male rats","authors":"S. Nosrati, M. Zarei, I. Salehi, S. Soleimani asl, A. Komaki, S. Moradkhani","doi":"10.34172/jsums.2020.13","DOIUrl":"https://doi.org/10.34172/jsums.2020.13","url":null,"abstract":"Background and aimsThe cardiac angiogenesis is one of the complications of diabetes. The oxidative stress occurs when there is an imbalance between the production of free radicals and antioxidant defense of the body. In diabetes mellitus, hyperglycemia induces increased oxidative stress through biological processes. Diabetes is also associated with reduced antioxidant defense by reducing glutathione, catalase, and superoxide dismutase. Rosa damascena Millhas antioxidant properties. This study aimed to investigate the effects of hydroalcoholic extract of R. damascena Millon cardiac angiogenesis in diabetic rats.MethodsInthis experimental study carried out in 2016, a total of 48 adult male Wistar rats (190-200 g) were randomly divided into 8 groups (n = 6) including control, extracts (200, 400, and 1000 mg/kg), diabetic, and diabetic plus extracts (200, 400, and 1000 mg/kg). Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ) (50 mg/kg) and the rats were gavaged with different doses of extract for 30 days. At the end of the treatment, serum levels of vascular endothelial growth factor (VEGF) were determined by enzyme-linked immunosorbent assay and the rat hearts were removed for immunohistochemistry study.ResultsThe treatment with hydroalcoholic extract of R. damascene Mill had no significant effect on cardiac capillary density [F (7, 40) = 0.5, P > 0.05] and the serum levels of VEGF [F (7, 40) = 0.406, P > 0.05]. However, there was no significant difference in blood glucose level in extract groups compared to control rats as well as diabetic plus extract groups compared to diabetic rats [F (7,40) = 0.787, P > 0.05].ConclusionAccording to our results, the hydroalcoholic extract of R. damascene Mill had no effect on cardiac angiogenesis in the normal and diabetic subjects. These findings were probably due to the insufficient amounts of effective ingredients, especially flavonoids, in this plant, or the duration of extract administration.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131678760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aimsColorectal cancer (CRC) is known as the fourth leading cause of death across the world. The fate of patients depends on the metastatic spread of cancer cells. Micrometastases are small clusters of cancer cells with no diagnostic evidence during diagnosis and surgery. Therefore, experimental models for micrometastasis are necessary to investigate tumors. We developed a mouse model to evaluate micrometastasis of colon carcinoma cells by systemic injection of tumor cells.MethodsIn this study, stably transfected CT26 cells expressing Leishmania major GP63 were intravenously (IV) injected into BALB/c mice for induction of micrometastases. The mice were divided into three groups and the groups were sacrificed on days 3, 7, and 14 of the injection. reverse transcriptase-polymerase chain reaction (RT-PCR) was performed on tissue samples to detect Gp63 gene.ResultsOur results showed the successful construction and transfection of pcDNA3 L. majorGp63 into CT26 cells. After IV injection, total cellular RNA was extracted and the Gp63 gene was detected in the liver, lung, and kidney but not in the colon.ConclusionDue to the significance of micrometastasis and the need to establish simple models for cancer research, an experimental mouse model was developed. CT26 tumor cells stably expressing Gp63 generated a potent system for diagnosis of micrometastatic cells in tissues. Injection into the tail vein is a practical model for cancer research because of the lower fatality rate and no need for anesthesia.
{"title":"A new in vivo model for analysis of colon carcinoma micrometastasis in BALB/c mice","authors":"Roya Abedizadeh, H. Rezvan, A. Nourian","doi":"10.34172/jsums.2020.14","DOIUrl":"https://doi.org/10.34172/jsums.2020.14","url":null,"abstract":"Background and aimsColorectal cancer (CRC) is known as the fourth leading cause of death across the world. The fate of patients depends on the metastatic spread of cancer cells. Micrometastases are small clusters of cancer cells with no diagnostic evidence during diagnosis and surgery. Therefore, experimental models for micrometastasis are necessary to investigate tumors. We developed a mouse model to evaluate micrometastasis of colon carcinoma cells by systemic injection of tumor cells.MethodsIn this study, stably transfected CT26 cells expressing Leishmania major GP63 were intravenously (IV) injected into BALB/c mice for induction of micrometastases. The mice were divided into three groups and the groups were sacrificed on days 3, 7, and 14 of the injection. reverse transcriptase-polymerase chain reaction (RT-PCR) was performed on tissue samples to detect Gp63 gene.ResultsOur results showed the successful construction and transfection of pcDNA3 L. majorGp63 into CT26 cells. After IV injection, total cellular RNA was extracted and the Gp63 gene was detected in the liver, lung, and kidney but not in the colon.ConclusionDue to the significance of micrometastasis and the need to establish simple models for cancer research, an experimental mouse model was developed. CT26 tumor cells stably expressing Gp63 generated a potent system for diagnosis of micrometastatic cells in tissues. Injection into the tail vein is a practical model for cancer research because of the lower fatality rate and no need for anesthesia.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134498784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soheila Banitalebi, S. Etemadifar, S. Kheiri, Reza Masoudi
Background and aimsCaring for patients with multiple sclerosis causes family caregivers many problems and challenges. Self-management interventions can facilitate the caring process and increase the quality of patient care. Therefore, the aim of this study was to investigate the effect of a self-management program on Self-concept of the family caregivers of multiple sclerosis patients.MethodsThis quasi-experimental study was conducted in 2018 at the MS Treatment Center of Shahrekord. The samples were selected through convenience sampling method. First, participants were assigned to two groups of men and women by stratified random sampling, and then men and women were assigned randomly to intervention (n=35) and control (n=35) groups. For the intervention group, the self-management program was implemented twice a week in 8 sessions. Data collection was performed using the Coopersmith self-concept Inventory in two groups before, immediately after, and three months after the intervention. Data were analyzed by SPSS version 16.0.ResultsThe mean scores of self-concept in the intervention and control groups before the intervention were 72.6±9.1 and 72±10.6, respectively. There was no significant difference between the mean score of self-concept between the intervention and control groups before the intervention (P > 0.05). The mean scores of self-concept immediately after the intervention in the two groups were 86.4±9.2 and 73±10.6, and three months after the intervention, they were 103±7.4 and 73.9±10.5, respectively. A significant increase in the scores of self-concept in the intervention group (P<0.001) was observed. Moreover, the independent t test showed a significant difference in the two groups immediately after and three months after the intervention (P<0.001).ConclusionSelf-management program increased the self-concept of multiple sclerosis (MS) patients’ caregivers. Therefore, self-management can play a critical role in improving the quality of life of family caregivers and coping with the physical and psychological stress related to their caring role
{"title":"The effect of implementing self-management plan on selfconcept of family caregivers of multiple sclerosis patients","authors":"Soheila Banitalebi, S. Etemadifar, S. Kheiri, Reza Masoudi","doi":"10.34172/jsums.2020.12","DOIUrl":"https://doi.org/10.34172/jsums.2020.12","url":null,"abstract":"Background and aimsCaring for patients with multiple sclerosis causes family caregivers many problems and challenges. Self-management interventions can facilitate the caring process and increase the quality of patient care. Therefore, the aim of this study was to investigate the effect of a self-management program on Self-concept of the family caregivers of multiple sclerosis patients.MethodsThis quasi-experimental study was conducted in 2018 at the MS Treatment Center of Shahrekord. The samples were selected through convenience sampling method. First, participants were assigned to two groups of men and women by stratified random sampling, and then men and women were assigned randomly to intervention (n=35) and control (n=35) groups. For the intervention group, the self-management program was implemented twice a week in 8 sessions. Data collection was performed using the Coopersmith self-concept Inventory in two groups before, immediately after, and three months after the intervention. Data were analyzed by SPSS version 16.0.ResultsThe mean scores of self-concept in the intervention and control groups before the intervention were 72.6±9.1 and 72±10.6, respectively. There was no significant difference between the mean score of self-concept between the intervention and control groups before the intervention (P > 0.05). The mean scores of self-concept immediately after the intervention in the two groups were 86.4±9.2 and 73±10.6, and three months after the intervention, they were 103±7.4 and 73.9±10.5, respectively. A significant increase in the scores of self-concept in the intervention group (P<0.001) was observed. Moreover, the independent t test showed a significant difference in the two groups immediately after and three months after the intervention (P<0.001).ConclusionSelf-management program increased the self-concept of multiple sclerosis (MS) patients’ caregivers. Therefore, self-management can play a critical role in improving the quality of life of family caregivers and coping with the physical and psychological stress related to their caring role","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134408950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aimsToday, the prevalence of structural and functional disorders of sperm and subsequently the possibility of occurrence of autism, spontaneous abortion, and infertility has increased dramatically. This study aimed to investigate the potential effects of myo-inositol and N-acetyl-L-cysteine (NAC) on the improvement of processed spermatozoa indices.MethodsIn this study, 63 patients with male factor infertility were studied in Hazrat Zahra Infertility Center of Shahrekord. To do liquefaction, the semen sample was incubated at 37°C for 20 minutes. The Density Gradient Centrifugation protocol was used to process sperm. The processed sperm samples were incubated at 37°C for 20 minutes in four groups of control, myo-inositol (2 mg/mL), NAC antioxidant (10 Mm/L) and myo-inositol+NAC. All biological parameters of sperm were evaluated using Makler slide, SQA-V sperm analyzer gold version 2.48, TUNEL assay, and Toluidine blue staining.ResultsIn the present study, 63 men aged 22-58 years with infertility complaints were studied. The NAC group and the myo-inositol group exhibited significantly higher motility in comparison with the control group (P 0.05).ConclusionNAC and myo-inositol were able to improve certain indices such as sperm motility and integrity; therefore, the quality of sperm could be improved by these drugs to treat infertility.
{"title":"Effect of Myo-inositol and N-acetyl-L-cysteine on processed human spermatozoa for use in modern methods of fertility treatment","authors":"M. Nemati, Sadra Ansaripour, Naghmeh Samadi","doi":"10.34172/jsums.2020.09","DOIUrl":"https://doi.org/10.34172/jsums.2020.09","url":null,"abstract":"Background and aimsToday, the prevalence of structural and functional disorders of sperm and subsequently the possibility of occurrence of autism, spontaneous abortion, and infertility has increased dramatically. This study aimed to investigate the potential effects of myo-inositol and N-acetyl-L-cysteine (NAC) on the improvement of processed spermatozoa indices.MethodsIn this study, 63 patients with male factor infertility were studied in Hazrat Zahra Infertility Center of Shahrekord. To do liquefaction, the semen sample was incubated at 37°C for 20 minutes. The Density Gradient Centrifugation protocol was used to process sperm. The processed sperm samples were incubated at 37°C for 20 minutes in four groups of control, myo-inositol (2 mg/mL), NAC antioxidant (10 Mm/L) and myo-inositol+NAC. All biological parameters of sperm were evaluated using Makler slide, SQA-V sperm analyzer gold version 2.48, TUNEL assay, and Toluidine blue staining.ResultsIn the present study, 63 men aged 22-58 years with infertility complaints were studied. The NAC group and the myo-inositol group exhibited significantly higher motility in comparison with the control group (P 0.05).ConclusionNAC and myo-inositol were able to improve certain indices such as sperm motility and integrity; therefore, the quality of sperm could be improved by these drugs to treat infertility.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132130586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ghasemnian, Zeinab Iddehloei, A. Rahmani, Mozhgan Usefpour
Background and aimsThe purpose of this study was to examine the effect of 2 months of endurance training (ET) along with ginger consumption on the serum levels of liver enzymes (ALT and AST), enzymatic activity of superoxide dismutase, and malondialdehyde (MDA) in liver tissue in male Wistar rats.Material and Methods40 adult male Wistar rats were randomly divided into 5 groups according to the weight as follows: control (n=8), sham (n=8), ET (n=8), ginger (n=8), and ET + ginger (n=8). The training protocol was an ET program on a treadmill for two months (5 days a week). Besides standard water and food, in groups using the supplement, 100 mg of ginger solution per kg body weight of the rats was injected three days a week. Then, 48 hours after the last training session and after 8 hours of fasting, blood and tissue samples were collected over night and the serum levels of liver enzymes (ALT and AST), MDA level of the liver tissue, and activity of the liver superoxide dismutase (SOD) were measured. One-way ANOVA and Tukey post-hoc test were used for data analysis.ResultsThe results showed that after 8 weeks, the activity of liver SOD in ET group (131.7 ± 18.6, P = 0.001) and ET + Ginger group (130.2 ± 31.3, P = 0.001) significantly increased in comparison with the control group (83.8 ± 14.9). Moreover, liver MDAlevels in the ET group (0.38 ± 0.08, P = 0.008) and ET + Ginger group (0.37 ± 0.09, P = 0.013) significantly increased in comparison with the control group (0.25.0 ± 03). However, 8 weeks of ET coupled with ginger consumption had no effects on the serum levels of AST and ALT (P > 0.05). Furthermore, ginger had no effect on MDA level and enzymatic activity of SOD (P > 0.05).ConclusionThis study does not support the protective effects of ginger on the reduction of liver enzymes levels and improvement of the antioxidant status.
{"title":"Effects of ginger along with exercise training on serum levels of ALT and AST liver enzymes and malondialdehyde and the activity of liver tissue superoxide dismutase in male Wistar rats","authors":"A. Ghasemnian, Zeinab Iddehloei, A. Rahmani, Mozhgan Usefpour","doi":"10.34172/jsums.2020.11","DOIUrl":"https://doi.org/10.34172/jsums.2020.11","url":null,"abstract":"Background and aimsThe purpose of this study was to examine the effect of 2 months of endurance training (ET) along with ginger consumption on the serum levels of liver enzymes (ALT and AST), enzymatic activity of superoxide dismutase, and malondialdehyde (MDA) in liver tissue in male Wistar rats.Material and Methods40 adult male Wistar rats were randomly divided into 5 groups according to the weight as follows: control (n=8), sham (n=8), ET (n=8), ginger (n=8), and ET + ginger (n=8). The training protocol was an ET program on a treadmill for two months (5 days a week). Besides standard water and food, in groups using the supplement, 100 mg of ginger solution per kg body weight of the rats was injected three days a week. Then, 48 hours after the last training session and after 8 hours of fasting, blood and tissue samples were collected over night and the serum levels of liver enzymes (ALT and AST), MDA level of the liver tissue, and activity of the liver superoxide dismutase (SOD) were measured. One-way ANOVA and Tukey post-hoc test were used for data analysis.ResultsThe results showed that after 8 weeks, the activity of liver SOD in ET group (131.7 ± 18.6, P = 0.001) and ET + Ginger group (130.2 ± 31.3, P = 0.001) significantly increased in comparison with the control group (83.8 ± 14.9). Moreover, liver MDAlevels in the ET group (0.38 ± 0.08, P = 0.008) and ET + Ginger group (0.37 ± 0.09, P = 0.013) significantly increased in comparison with the control group (0.25.0 ± 03). However, 8 weeks of ET coupled with ginger consumption had no effects on the serum levels of AST and ALT (P > 0.05). Furthermore, ginger had no effect on MDA level and enzymatic activity of SOD (P > 0.05).ConclusionThis study does not support the protective effects of ginger on the reduction of liver enzymes levels and improvement of the antioxidant status.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126519631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：