M. Behnam Moghadam, H. Matinhomaee, M. Azarbayjani
Background and aims: Chlorpyrifos (CPF) is an insecticide that is widely used in the world. The purpose of this research was to investigate the effect of 4-week aerobic exercise and eugenol supplementation on the phosphatidylinositol-3-kinases/protein kinase/mammalian target of rapamycin (Pi3K/AKT/mTOR) pathway on the skeletal muscle of male rats poisoned with CPF. Methods: Overall, 12-week-old female rats were used in this experimental research. The rats were randomly divided into 8 groups (8 rats in each group), including healthy control, toxic control, poison solvent, corn oil solvent, poisoned+eugenol, poisoned+aerobic exercise, and poisoned+aerobic exercise+eugenol. Moderate training was in the range of 50-60% VO2 max, including 5 training sessions per week (treadmill). Poisoning was performed with CPF poison with a dose of 3 mg/kg, and the dose of eugenol was determined to be 250 mg/kg. Results: There was no significant difference between the groups in terms of mTOR and AKT expression (P=0.369, P=0.59). However, the expression of PI3k in the poisoned control group was lower than that in the healthy control group (P=0.049). In addition, the expression of PI3k was higher in the poisoned+eugenol+exercise group compared to the poisoned control group (P=0.009). The corn solvent group also had a higher PI3k expression in comparison to the poisoned control group (P=0.025). Finally, there was no significant difference among the other groups. Conclusion: In general, 4 weeks of CPF poisoning caused a significant decrease in PI3K, but it did not have a significant effect on AKT and mTOR. Based on the finding, 4 aerobic exercises and eugenol consumption could significantly increase in PI3K, while it had no significant effect on AKT and mTOR.
{"title":"The effect of aerobic training and eugenol supplementation on the PI3K/AKT/mTOR pathway in skeletal muscle of male rats poisoned with chlorpyrifos","authors":"M. Behnam Moghadam, H. Matinhomaee, M. Azarbayjani","doi":"10.34172/jsums.2023.795","DOIUrl":"https://doi.org/10.34172/jsums.2023.795","url":null,"abstract":"Background and aims: Chlorpyrifos (CPF) is an insecticide that is widely used in the world. The purpose of this research was to investigate the effect of 4-week aerobic exercise and eugenol supplementation on the phosphatidylinositol-3-kinases/protein kinase/mammalian target of rapamycin (Pi3K/AKT/mTOR) pathway on the skeletal muscle of male rats poisoned with CPF. Methods: Overall, 12-week-old female rats were used in this experimental research. The rats were randomly divided into 8 groups (8 rats in each group), including healthy control, toxic control, poison solvent, corn oil solvent, poisoned+eugenol, poisoned+aerobic exercise, and poisoned+aerobic exercise+eugenol. Moderate training was in the range of 50-60% VO2 max, including 5 training sessions per week (treadmill). Poisoning was performed with CPF poison with a dose of 3 mg/kg, and the dose of eugenol was determined to be 250 mg/kg. Results: There was no significant difference between the groups in terms of mTOR and AKT expression (P=0.369, P=0.59). However, the expression of PI3k in the poisoned control group was lower than that in the healthy control group (P=0.049). In addition, the expression of PI3k was higher in the poisoned+eugenol+exercise group compared to the poisoned control group (P=0.009). The corn solvent group also had a higher PI3k expression in comparison to the poisoned control group (P=0.025). Finally, there was no significant difference among the other groups. Conclusion: In general, 4 weeks of CPF poisoning caused a significant decrease in PI3K, but it did not have a significant effect on AKT and mTOR. Based on the finding, 4 aerobic exercises and eugenol consumption could significantly increase in PI3K, while it had no significant effect on AKT and mTOR.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129411266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Khosravi Zadeh, Farhad Rahmani Nia, A. Damirchi, M. Kargarfard
Background and aims: Diabetic cardiomyopathy (DCM) is a major cause of morbidity and mortality among diabetic patients. This study aimed to compare and investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on oxidative stress as one of the key links in the development of DCM in mice with type 2 diabetes mellitus (T2DM). Methods: Forty male C57BL/6J mice were randomly assigned to four groups of equal number (Control, T2DM, T2DM+HIIT, and T2DM+MICT). After the induction of T2DM, HIIT and MICT programs were conducted 5 days a week for 8 weeks. At the end of the experimental period, blood and heart samples were collected for subsequent measurements. Results: T2DM significantly up-regulated the levels of advanced glycation end products (AGEs, P=0.001) and the expression of 15-lipoxygenase (15-LOX, P=0.001) and 4-hydroxy-2-nonenal (4-HNE, P=0.001) compared to controlled mice. After 8 weeks of training, HIIT and MICT programs increased the levels of insulin (P<0.001) while reducing the levels of fasting blood glucose (P<0.001, P=0.024, respectively). On the other hand, it was found that HIIT and MICT programs significantly decreased the levels of AGEs (P<0.001), expression of 15-LOX (P=0.006, P=0.019, respectively), and 4-HNE (P=0.008 and P=0.035, respectively). Conclusion: Our findings revealed that exercise training, particularly MICT, will be highly helpful in the prevention of DCM through the improvement of glucose metabolism and reduction of 15-LOX expression.
{"title":"The effect of eight weeks of high-intensity interval training and moderate-intensity continuous training on some factors causing oxidative stress in the cardiomyocytes of mice with type II diabetes","authors":"Ali Khosravi Zadeh, Farhad Rahmani Nia, A. Damirchi, M. Kargarfard","doi":"10.34172/jsums.2023.798","DOIUrl":"https://doi.org/10.34172/jsums.2023.798","url":null,"abstract":"Background and aims: Diabetic cardiomyopathy (DCM) is a major cause of morbidity and mortality among diabetic patients. This study aimed to compare and investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on oxidative stress as one of the key links in the development of DCM in mice with type 2 diabetes mellitus (T2DM). Methods: Forty male C57BL/6J mice were randomly assigned to four groups of equal number (Control, T2DM, T2DM+HIIT, and T2DM+MICT). After the induction of T2DM, HIIT and MICT programs were conducted 5 days a week for 8 weeks. At the end of the experimental period, blood and heart samples were collected for subsequent measurements. Results: T2DM significantly up-regulated the levels of advanced glycation end products (AGEs, P=0.001) and the expression of 15-lipoxygenase (15-LOX, P=0.001) and 4-hydroxy-2-nonenal (4-HNE, P=0.001) compared to controlled mice. After 8 weeks of training, HIIT and MICT programs increased the levels of insulin (P<0.001) while reducing the levels of fasting blood glucose (P<0.001, P=0.024, respectively). On the other hand, it was found that HIIT and MICT programs significantly decreased the levels of AGEs (P<0.001), expression of 15-LOX (P=0.006, P=0.019, respectively), and 4-HNE (P=0.008 and P=0.035, respectively). Conclusion: Our findings revealed that exercise training, particularly MICT, will be highly helpful in the prevention of DCM through the improvement of glucose metabolism and reduction of 15-LOX expression.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116359821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Osteoarthritis (OA) is the most common skeletal and excruciating disease worldwide. This study aimed to investigate bromelain’s effect and underlying mechanism on OA symptoms. Methods: This systematic review was designed according to the PRISMA guidelines. An extensive search was undertaken in various databases, including PubMed, Web of Science, EMBASE, and Scopus. Finally, 14 articles were retrieved considering the inclusion and exclusion criteria of the study. The desired data were extracted and entered into an Excel file, and the outcomes of the studies underwent investigation. Results: Bromelain downregulates inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin 6 (IL-6), IL-8, IL-1β, and interferon γ expression in synovial fibroblasts. In addition, bromelain inserts analgesic effects by decreasing vascular permeability to bradykinin and inhabitation its generation. Bromelain counteracts by increasing the levels of TNF-α, IL-1β, inducible nitric oxide synthase (iONS) levels, and lipid peroxidation while reducing those of superoxide dismutase, catalase, and prolidase. Another main antinociceptive effect property of bromelain is associated with its anti-inflammatory effect by relieving neuroinflammation and synovial membrane inflammation. Conclusion: Bromelain indicated good therapeutic effects on reducing OA symptoms due to its anti-inflammatory and antioxidant effects. Although no specific bromelain-related side effects were not reported in the included studies, it is recommended that more laboratory studies should be conducted with different doses and appropriate methodology.
背景和目的:骨关节炎(OA)是世界范围内最常见的骨骼和疼痛性疾病。本研究旨在探讨菠萝蛋白酶对OA症状的作用及其机制。方法:本系统评价按照PRISMA指南设计。在PubMed、Web of Science、EMBASE和Scopus等数据库中进行了广泛的搜索。最后，根据本研究的纳入和排除标准，检索到14篇文章。提取所需的数据并输入Excel文件，并对研究结果进行调查。结果:菠萝蛋白酶下调滑膜成纤维细胞中肿瘤坏死因子(TNF)-α、白细胞介素6 (IL-6)、IL-8、IL-1β、干扰素γ等炎性细胞因子的表达。此外，菠萝蛋白酶通过降低血管对缓激肽的通透性和抑制其产生来插入镇痛作用。菠萝蛋白酶通过增加TNF-α、IL-1β、诱导型一氧化氮合酶(iONS)水平和脂质过氧化水平来抵消，同时降低超氧化物歧化酶、过氧化氢酶和脯氨酸酶的水平。菠萝蛋白酶的另一个主要抗伤性作用与它的抗炎作用有关，它可以缓解神经炎症和滑膜炎症。结论:菠萝蛋白酶具有抗炎、抗氧化作用，对缓解OA症状有较好的疗效。虽然在纳入的研究中没有报告与菠萝蛋白酶相关的特定副作用，但建议使用不同的剂量和适当的方法进行更多的实验室研究。
{"title":"The effects of bromelain on osteoarthritis symptoms: A systematic review","authors":"Shahin Asgari Savadjani, Farshad Yadollahi, Armin Khaghani","doi":"10.34172/jsums.2023.789","DOIUrl":"https://doi.org/10.34172/jsums.2023.789","url":null,"abstract":"Background and aims: Osteoarthritis (OA) is the most common skeletal and excruciating disease worldwide. This study aimed to investigate bromelain’s effect and underlying mechanism on OA symptoms. Methods: This systematic review was designed according to the PRISMA guidelines. An extensive search was undertaken in various databases, including PubMed, Web of Science, EMBASE, and Scopus. Finally, 14 articles were retrieved considering the inclusion and exclusion criteria of the study. The desired data were extracted and entered into an Excel file, and the outcomes of the studies underwent investigation. Results: Bromelain downregulates inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin 6 (IL-6), IL-8, IL-1β, and interferon γ expression in synovial fibroblasts. In addition, bromelain inserts analgesic effects by decreasing vascular permeability to bradykinin and inhabitation its generation. Bromelain counteracts by increasing the levels of TNF-α, IL-1β, inducible nitric oxide synthase (iONS) levels, and lipid peroxidation while reducing those of superoxide dismutase, catalase, and prolidase. Another main antinociceptive effect property of bromelain is associated with its anti-inflammatory effect by relieving neuroinflammation and synovial membrane inflammation. Conclusion: Bromelain indicated good therapeutic effects on reducing OA symptoms due to its anti-inflammatory and antioxidant effects. Although no specific bromelain-related side effects were not reported in the included studies, it is recommended that more laboratory studies should be conducted with different doses and appropriate methodology.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122639347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroinflammation alleviation","authors":"Seyed-Amirabbas Ahadiat, Z. Hosseinian","doi":"10.34172/jsums.2023.778","DOIUrl":"https://doi.org/10.34172/jsums.2023.778","url":null,"abstract":"","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128242779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khadijeh Saravani, P. Ramezannezhad, Mohaddese Delpisheh, Batool Shahraki Mojahed, Omid Bameri, H. Aali
Background and aims: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields of medicine. This review article was performed to investigate the hormone disturbance of long-term tramadol and methadone use in women. Methods: Keywords were determined using the MeSH browser and then searched in ISI, Scopus, EMBASE, and PubMed databases on 25.5.2022. The articles with non-English language, articles whose full text was not retrieved, and studies that were irrelevant to the aim of this study were excluded from the investigation. Results: Methadone and tramadol affected a sexual hormone in women through an impact on the hypothalamic-pituitary-gonadal axis. They could reduce the levels of follicle stimulating hormone and luteinizing hormone, increase prolactin production, and finally, reduce gonadal steroids. Opioids also could influence thyroid and adrenal glands and subsequently increase thyroid-stimulating hormone, and reduce dehydroepiandrosterone. Eventually, this mechanism caused a disturbance in sexual hormone disturbance in women. Conclusion: Overall, long-term methadone and tramadol consumption as opioid substances could cause sexual hormone disturbance in women.
{"title":"The complications of tramadol and methadone use to women’s sexual hormone","authors":"Khadijeh Saravani, P. Ramezannezhad, Mohaddese Delpisheh, Batool Shahraki Mojahed, Omid Bameri, H. Aali","doi":"10.34172/jsums.2023.752","DOIUrl":"https://doi.org/10.34172/jsums.2023.752","url":null,"abstract":"Background and aims: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields of medicine. This review article was performed to investigate the hormone disturbance of long-term tramadol and methadone use in women. Methods: Keywords were determined using the MeSH browser and then searched in ISI, Scopus, EMBASE, and PubMed databases on 25.5.2022. The articles with non-English language, articles whose full text was not retrieved, and studies that were irrelevant to the aim of this study were excluded from the investigation. Results: Methadone and tramadol affected a sexual hormone in women through an impact on the hypothalamic-pituitary-gonadal axis. They could reduce the levels of follicle stimulating hormone and luteinizing hormone, increase prolactin production, and finally, reduce gonadal steroids. Opioids also could influence thyroid and adrenal glands and subsequently increase thyroid-stimulating hormone, and reduce dehydroepiandrosterone. Eventually, this mechanism caused a disturbance in sexual hormone disturbance in women. Conclusion: Overall, long-term methadone and tramadol consumption as opioid substances could cause sexual hormone disturbance in women.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128897902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Muscle atrophy is a complication of type 2 diabetes, in which the expression of atrophy-related genes is increased. The present study aimed to investigate the effect of high-intensity interval training (HIIT) and metformin on gene expression of two atrophy-related genes (i.e., FoxO1 and Atrogin-1) in the skeletal muscle of diabetic mice. Methods: A total of 30 mice (C57BL/6) were assigned to two groups: control (n=6), and high-fat diet (HFD) (n=24). The mice in the HFD group were fed a HDF for 16 weeks. Then, diabetes was induced in mice by HFD. Then, they were divided into 4 groups as follows: (i) diabetic control, (ii) diabetes + metformin (DM), (iii) diabetes + HIIT (DH), and (iv) diabetes + metformin + HIIT (DMH). The DM group took metformin, the HIIT group performed a HIIT program, and the DMH group had both HIIT and metformin. The real-time PCR methods were used to measure the mRNA expression of FoxO1 and Atrogin-1. Results: The findings showed that HFD-induced diabetes caused increases in the expression of FoxO1 (P=0.0006) and Atrogin-1 (P=0.0008), and HIIT could restrain these increments (P=0.086, P=0.041). However, the decreasing effect of metformin on the expression of these genes was not significant (P=0.15) and the combined effect of HIIT and metformin on the expression of these genes was not greater than the individual effect of HIIT (P=0.64). Conclusion: These results indicated that HIIT (but not metformin) may prevent type 2 diabetes-induced downregulation of FoxO1 and Atrogin-1 in skeletal muscle, and metformin could not affect the impact of the training on these atrophy-related genes.
{"title":"The effect of metformin along with high-intensity interval training on gene expression of FoxO1 and Atrogin-1 in type 2 diabetic mice","authors":"Atefeh Rahimi, M. Delfan, Seed Daneshyar","doi":"10.34172/jsums.2023.786","DOIUrl":"https://doi.org/10.34172/jsums.2023.786","url":null,"abstract":"Background and aims: Muscle atrophy is a complication of type 2 diabetes, in which the expression of atrophy-related genes is increased. The present study aimed to investigate the effect of high-intensity interval training (HIIT) and metformin on gene expression of two atrophy-related genes (i.e., FoxO1 and Atrogin-1) in the skeletal muscle of diabetic mice. Methods: A total of 30 mice (C57BL/6) were assigned to two groups: control (n=6), and high-fat diet (HFD) (n=24). The mice in the HFD group were fed a HDF for 16 weeks. Then, diabetes was induced in mice by HFD. Then, they were divided into 4 groups as follows: (i) diabetic control, (ii) diabetes + metformin (DM), (iii) diabetes + HIIT (DH), and (iv) diabetes + metformin + HIIT (DMH). The DM group took metformin, the HIIT group performed a HIIT program, and the DMH group had both HIIT and metformin. The real-time PCR methods were used to measure the mRNA expression of FoxO1 and Atrogin-1. Results: The findings showed that HFD-induced diabetes caused increases in the expression of FoxO1 (P=0.0006) and Atrogin-1 (P=0.0008), and HIIT could restrain these increments (P=0.086, P=0.041). However, the decreasing effect of metformin on the expression of these genes was not significant (P=0.15) and the combined effect of HIIT and metformin on the expression of these genes was not greater than the individual effect of HIIT (P=0.64). Conclusion: These results indicated that HIIT (but not metformin) may prevent type 2 diabetes-induced downregulation of FoxO1 and Atrogin-1 in skeletal muscle, and metformin could not affect the impact of the training on these atrophy-related genes.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"10 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116781358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faezeh Dehestani Ardakani, E. Salehi, Majid Morovati-Sharifabad, Amin Paidar Ardakani, M. S. Heydarnejad
Background and aims: Wound healing is one of the most important issues in medical science. Synthetic drugs have long been introduced and used to speed up the healing process of wounds, but most of them have many side effects. The present study was performed to evaluate the healing efficiency of watercress seed mucilage (Lepidium sativum L.) on wounds. Methods: In this study, the animals were randomly divided into five groups. The treatment groups were (1), (2), (3), sham (4), and control (5). The treatment groups were treated with 20%, 10%, and 5% watercress seed mucilage in the Eucerin base, respectively, and the sham was treated with Eucerin, while the control received no treatment. Then, 5 pairs of full-thickness wounds with a diameter of 7 mm were created on both sides of the rabbit’s spine. Macroscopic and wound area studies were performed on days 4, 7, and 14 after surgery. Results: According to the analysis of variance, there was a significant difference between groups 1, 2, 3, sham, and control (P=0.001), but no significant difference was observed between group 3, sham group, and control group (P=0.993). Based on these findings, at the end of the treatment period, group 1 had the highest healing rate and the lowest wound area (1.12±0.77) compared to group 2 (4.42±0.30) and 3 (7.05±0.35), as well as the sham (8.34±1.10) and control (8.50±1.90) groups. Thus, the treatment method of this group has been more effective in wound healing than that of the other treatment groups. Conclusion: It seems that watercress seed mucilage can treat wounds due to its important compounds such as flavonoids, phenols, and vitamins A and C.
{"title":"Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits","authors":"Faezeh Dehestani Ardakani, E. Salehi, Majid Morovati-Sharifabad, Amin Paidar Ardakani, M. S. Heydarnejad","doi":"10.34172/jsums.2023.681","DOIUrl":"https://doi.org/10.34172/jsums.2023.681","url":null,"abstract":"Background and aims: Wound healing is one of the most important issues in medical science. Synthetic drugs have long been introduced and used to speed up the healing process of wounds, but most of them have many side effects. The present study was performed to evaluate the healing efficiency of watercress seed mucilage (Lepidium sativum L.) on wounds. Methods: In this study, the animals were randomly divided into five groups. The treatment groups were (1), (2), (3), sham (4), and control (5). The treatment groups were treated with 20%, 10%, and 5% watercress seed mucilage in the Eucerin base, respectively, and the sham was treated with Eucerin, while the control received no treatment. Then, 5 pairs of full-thickness wounds with a diameter of 7 mm were created on both sides of the rabbit’s spine. Macroscopic and wound area studies were performed on days 4, 7, and 14 after surgery. Results: According to the analysis of variance, there was a significant difference between groups 1, 2, 3, sham, and control (P=0.001), but no significant difference was observed between group 3, sham group, and control group (P=0.993). Based on these findings, at the end of the treatment period, group 1 had the highest healing rate and the lowest wound area (1.12±0.77) compared to group 2 (4.42±0.30) and 3 (7.05±0.35), as well as the sham (8.34±1.10) and control (8.50±1.90) groups. Thus, the treatment method of this group has been more effective in wound healing than that of the other treatment groups. Conclusion: It seems that watercress seed mucilage can treat wounds due to its important compounds such as flavonoids, phenols, and vitamins A and C.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131949221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
For better management of acute kidney injury (AKI) and prevention of progressive renal injury, it is extremely important to manage infections such as gastroenteritis. In addition, anuria is considered a risk factor for AKI and even causes death in patients. An 18-month-old boy with vomiting and diarrhea for three days and anuria for 24 hours was referred to Farsan hospital. The patient had bulky and watery diarrhea about 7-8 times a day and vomited 3-4 times a day which was containing food particles. He had a fever on the first and second days. Ultrasound findings revealed that the right kidney did not exist, and the left kidney was affected by compensatory hypertrophy. Disorders in the patient’s blood biochemical factors were also observed. Acidosis and other biochemical disorders were treated with bicarbonate drip, allopurinol, Lasix drip, and dopamine drip. After about 18 hours, anuria was treated.
{"title":"Anuria in solitary kidney patient with gastroenteritis: A case report study","authors":"S. Mohajeri, A. Salehifard, Aliasghar Rabiei","doi":"10.34172/jsums.2023.715","DOIUrl":"https://doi.org/10.34172/jsums.2023.715","url":null,"abstract":"For better management of acute kidney injury (AKI) and prevention of progressive renal injury, it is extremely important to manage infections such as gastroenteritis. In addition, anuria is considered a risk factor for AKI and even causes death in patients. An 18-month-old boy with vomiting and diarrhea for three days and anuria for 24 hours was referred to Farsan hospital. The patient had bulky and watery diarrhea about 7-8 times a day and vomited 3-4 times a day which was containing food particles. He had a fever on the first and second days. Ultrasound findings revealed that the right kidney did not exist, and the left kidney was affected by compensatory hypertrophy. Disorders in the patient’s blood biochemical factors were also observed. Acidosis and other biochemical disorders were treated with bicarbonate drip, allopurinol, Lasix drip, and dopamine drip. After about 18 hours, anuria was treated.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123946861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ameneh Zamani Sedehi, K. Ghatreh Samani, Roohollah Mohseni, A. Khaledifar
Background and aims: Atherosclerosis is one of the main reasons why people die from cardiovascular disease. The pathogenesis of atherosclerosis may have been aided by the deregulation of cellular and molecular events in peripheral blood mononuclear cells (PBMCs). This study aimed to investigate the alteration of the expression of matrix metallopeptidase-9 (MMP-9) in PBMCs of subjects who underwent angiography. Methods: Following a thorough clinical examination and anthropometric assessments, 90 individuals were divided into two groups: 56 coronary artery disease (CAD) participants (subjects with coronary artery stenosis≥50%) and 34 non-CAD participants (subjects with coronary artery stenosis≤30%). Then, this study evaluated fasting serum glucose (FSG), total cholesterol (Chol), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride (TG). Next, the severity of coronary artery stenosis was recorded. Additionally, real-time polymerase chain reaction (PCR) was used to assess the gene expression of MMP-9. MMP-9 protein level was also assessed using western blot techniques. The overexpression of MMP-9 and elevated level of FSG were positively associated with coronary artery stenosis. Results: Our results revealed that MMP-9 was upregulated both at the level of transcription and translation. Moreover, the upregulation of MMP-9 had a significant positive correlation with the severity of coronary artery stenosis. Conclusion: Significant correlation between the overexpression of MMP-9 and coronary artery stenosis confirms our hypothesis that the upregulation of MMP-9 in PBMCs has an important role in the pathogenesis of atherosclerosis before monocyte recruitment and its subsequent processes.
{"title":"Alteration in expression of matrix metalloproteinase-9 in peripheral blood mononuclear cells could be considered for estimating the severity of coronary artery stenosis","authors":"Ameneh Zamani Sedehi, K. Ghatreh Samani, Roohollah Mohseni, A. Khaledifar","doi":"10.34172/jsums.2023.852","DOIUrl":"https://doi.org/10.34172/jsums.2023.852","url":null,"abstract":"Background and aims: Atherosclerosis is one of the main reasons why people die from cardiovascular disease. The pathogenesis of atherosclerosis may have been aided by the deregulation of cellular and molecular events in peripheral blood mononuclear cells (PBMCs). This study aimed to investigate the alteration of the expression of matrix metallopeptidase-9 (MMP-9) in PBMCs of subjects who underwent angiography. Methods: Following a thorough clinical examination and anthropometric assessments, 90 individuals were divided into two groups: 56 coronary artery disease (CAD) participants (subjects with coronary artery stenosis≥50%) and 34 non-CAD participants (subjects with coronary artery stenosis≤30%). Then, this study evaluated fasting serum glucose (FSG), total cholesterol (Chol), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride (TG). Next, the severity of coronary artery stenosis was recorded. Additionally, real-time polymerase chain reaction (PCR) was used to assess the gene expression of MMP-9. MMP-9 protein level was also assessed using western blot techniques. The overexpression of MMP-9 and elevated level of FSG were positively associated with coronary artery stenosis. Results: Our results revealed that MMP-9 was upregulated both at the level of transcription and translation. Moreover, the upregulation of MMP-9 had a significant positive correlation with the severity of coronary artery stenosis. Conclusion: Significant correlation between the overexpression of MMP-9 and coronary artery stenosis confirms our hypothesis that the upregulation of MMP-9 in PBMCs has an important role in the pathogenesis of atherosclerosis before monocyte recruitment and its subsequent processes.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130617646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Ulcerative colitis (UC) is a prevalent and long-term condition that causes inflammation, irritation, and ulcers in the colon. This systematic review aimed to evaluate the effect of seafood oil omega-3 supplementation on UC remission. Methods: PubMed, EMBASE, Web of Science, and Scopus databases were extensively searched on 25.5.2022 according to the PRISMA checklist. The studies were imported into EndNote X9. Data were extracted in Excel form, including the first author’s name, study setting, year of publication, sample size, sea oil type, intervention, and outcomes. Results: Seafood oil omega-3 supplementation reduced the levels of leukotriene B4, interleukin (IL)-2, IL-8, IL-1β, thromboxane A2, prostaglandin E2, scavenges-free radicals, and tumor necrosis factor-α (TNF-α). In addition, supplementation with this oil could decrease free radicals at the cellular level and subsequently increase antioxidant activity, which also mediates the inflammatory process itself. Conclusion: Most studies showed that omega-3 extracted from seafood can reduce inflammation and oxidative stress (OS) in intestinal cells. It also could improve clinical symptoms and scores of histological, sigmoidoscopic, and simple clinical colitis activity index (SCCAI). However, some studies reported no positive effects in this regard and confirmed that these compounds have no effect on improving UC symptoms.
背景和目的:溃疡性结肠炎(UC)是一种引起炎症、刺激和结肠溃疡的常见病和长期性疾病。本系统综述旨在评估补充海鲜油omega-3对UC缓解的影响。方法:根据PRISMA检查表，于2022年5月25日广泛检索PubMed、EMBASE、Web of Science、Scopus等数据库。这些研究被导入到EndNote X9。数据以Excel格式提取，包括第一作者姓名、研究设置、发表年份、样本量、海油类型、干预措施和结局。结果:补充海鲜油omega-3可降低白三烯B4、白细胞介素(IL)-2、IL-8、IL-1β、血栓素A2、前列腺素E2、清除自由基和肿瘤坏死因子-α (TNF-α)的水平。此外，补充这种油可以在细胞水平上减少自由基，随后增加抗氧化活性，这也介导了炎症过程本身。结论:大多数研究表明，从海鲜中提取的omega-3可以减少肠道细胞的炎症和氧化应激(OS)。它还能改善临床症状和组织学、乙状结肠镜及单纯临床结肠炎活动指数(SCCAI)评分。然而，一些研究报告在这方面没有积极作用，并证实这些化合物对改善UC症状没有作用。
{"title":"The effect of seafood oil omega-3 supplementation on ulcerative colitis remission: A systematic review","authors":"Hossein Mardani-Nafchi, Atieh Mohammadi-Nafchi","doi":"10.34172/jsums.2023.761","DOIUrl":"https://doi.org/10.34172/jsums.2023.761","url":null,"abstract":"Background and aims: Ulcerative colitis (UC) is a prevalent and long-term condition that causes inflammation, irritation, and ulcers in the colon. This systematic review aimed to evaluate the effect of seafood oil omega-3 supplementation on UC remission. Methods: PubMed, EMBASE, Web of Science, and Scopus databases were extensively searched on 25.5.2022 according to the PRISMA checklist. The studies were imported into EndNote X9. Data were extracted in Excel form, including the first author’s name, study setting, year of publication, sample size, sea oil type, intervention, and outcomes. Results: Seafood oil omega-3 supplementation reduced the levels of leukotriene B4, interleukin (IL)-2, IL-8, IL-1β, thromboxane A2, prostaglandin E2, scavenges-free radicals, and tumor necrosis factor-α (TNF-α). In addition, supplementation with this oil could decrease free radicals at the cellular level and subsequently increase antioxidant activity, which also mediates the inflammatory process itself. Conclusion: Most studies showed that omega-3 extracted from seafood can reduce inflammation and oxidative stress (OS) in intestinal cells. It also could improve clinical symptoms and scores of histological, sigmoidoscopic, and simple clinical colitis activity index (SCCAI). However, some studies reported no positive effects in this regard and confirmed that these compounds have no effect on improving UC symptoms.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123746408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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