Background and aims: This study aimed to investigate and compare the effect of early and late breast milk fortification on growth parameters in preterm infants. Methods: In this clinical trial, 90 preterm infants (28-32 weeks) admitted to the neonatal intensive care unit (NICU) of Hajar Hospital in Shahrekord, Iran were randomly divided into three groups. The fortification was performed when the milk intake reached 30 (group A), 70 (group B), and 100 cc/kg (group C). The height, weight, and head circumference of newborns were measured at the beginning of birth and 4 weeks after the birth. The incidence of sepsis and necrotizing enterocolitis, and milk tolerance were investigated as well. All analyses were conducted with Stata software, and P values<0.05 were considered statistically significant. Results: The value changes in the height, weight, and head circumference in all three groups at 4 weeks were significant (P<0.001). The mean weight changes in the A, B, and C groups were 727.33±163.85, 947.33±155.38, and 808.66±168.82, indicating a statistically significant difference (P<0.001). Further, the mean change of weight after 4 weeks showed statistically significant differences (P<0.001) among the A, B, and C groups. The weight gain in the B group was significantly higher than that of the A and C groups (P<0.05); however, no significant difference was observed in the mean weight gain between the A and C groups (P=0.264). Conclusion: The breast milk fortification when the milk intake reached 70 cc/kg had better efficiency on neonatal weight gain compared with the early and delayed fortification.
{"title":"Investigation of the effect of early and late breast milk enrichment on growth parameters in preterm infants: A randomized clinical trial","authors":"M. Hamidi, Nabiollah Asadpour, R. Choopani","doi":"10.34172/jsums.2022.28","DOIUrl":"https://doi.org/10.34172/jsums.2022.28","url":null,"abstract":"Background and aims: This study aimed to investigate and compare the effect of early and late breast milk fortification on growth parameters in preterm infants. Methods: In this clinical trial, 90 preterm infants (28-32 weeks) admitted to the neonatal intensive care unit (NICU) of Hajar Hospital in Shahrekord, Iran were randomly divided into three groups. The fortification was performed when the milk intake reached 30 (group A), 70 (group B), and 100 cc/kg (group C). The height, weight, and head circumference of newborns were measured at the beginning of birth and 4 weeks after the birth. The incidence of sepsis and necrotizing enterocolitis, and milk tolerance were investigated as well. All analyses were conducted with Stata software, and P values<0.05 were considered statistically significant. Results: The value changes in the height, weight, and head circumference in all three groups at 4 weeks were significant (P<0.001). The mean weight changes in the A, B, and C groups were 727.33±163.85, 947.33±155.38, and 808.66±168.82, indicating a statistically significant difference (P<0.001). Further, the mean change of weight after 4 weeks showed statistically significant differences (P<0.001) among the A, B, and C groups. The weight gain in the B group was significantly higher than that of the A and C groups (P<0.05); however, no significant difference was observed in the mean weight gain between the A and C groups (P=0.264). Conclusion: The breast milk fortification when the milk intake reached 70 cc/kg had better efficiency on neonatal weight gain compared with the early and delayed fortification.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132324309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Narges Maleki, K. Kasiri, Mohammad Reza Malek-Ahmadi, F. Deris
Background and aims: None of the available constipation treatments for children are completely successful. Therefore, the present study aimed to evaluate the effect of the polyethylene glycol (PEG) solution 40% and fig syrup on the treatment of chronic constipation in children. Methods: In this double-blind clinical trial, 120 patients with chronic functional constipation were selected and divided into two groups. The first group received 5 mL of fig syrup without senna 3 times daily, and the second group took PEG 40% syrup at 1 mL/kg of body weight per day (the dose was adjustable according to the patient’s condition and need). At weeks 0, 2, 4, and 6, a checklist containing questions about children’s constipation was completed by the researcher, and the data were analyzed by SPSS version 24. Results: Changes in the frequency of abdominal pain at fourth times 0, 2, 4, and 6 weeks demonstrated statistically significant differences between the two groups (P=0.044), and it was significantly lower the in PEG group; however, the defecation was not statistically significant (P=0.902). After six weeks, the frequency of painful defecation, difficult defecation straining during defecation, and fear of defecation was significantly lower in the group given PEG syrup compared to the fig syrup-receiving group (P=0.001). Conclusion: Overall, PEG syrup was significantly effective in treating chronic functional constipation in children compared to the fig syrup.
背景和目的:目前没有一种治疗儿童便秘的方法是完全成功的。因此，本研究旨在评价40%聚乙二醇(PEG)溶液与无花果糖浆治疗儿童慢性便秘的效果。方法:选择120例慢性功能性便秘患者进行双盲临床试验，随机分为两组。第一组给予不含番泻叶的无花果糖浆5 mL，每日3次;第二组给予PEG 40%糖浆，每日1 mL/kg体重(剂量可根据患者情况和需要调整)。在第0、2、4、6周，研究者填写儿童便秘问题清单，并使用SPSS version 24对数据进行分析。结果:两组患者第0、2、4、6周第4次腹痛频次变化差异均有统计学意义(P=0.044)， PEG组明显降低;排便量差异无统计学意义(P=0.902)。6周后，与无花果糖浆组相比，PEG糖浆组的排便疼痛、排便困难、排便紧张的频率显著降低(P=0.001)。结论:总体而言，与无花果糖浆相比，聚乙二醇糖浆对儿童慢性功能性便秘有显著疗效。
{"title":"Comparison of the effect of polyethylene glycol 40% and fig syrups on the treatment of chronic functional constipation in children: A randomized clinical trial","authors":"Narges Maleki, K. Kasiri, Mohammad Reza Malek-Ahmadi, F. Deris","doi":"10.34172/jsums.2022.26","DOIUrl":"https://doi.org/10.34172/jsums.2022.26","url":null,"abstract":"Background and aims: None of the available constipation treatments for children are completely successful. Therefore, the present study aimed to evaluate the effect of the polyethylene glycol (PEG) solution 40% and fig syrup on the treatment of chronic constipation in children. Methods: In this double-blind clinical trial, 120 patients with chronic functional constipation were selected and divided into two groups. The first group received 5 mL of fig syrup without senna 3 times daily, and the second group took PEG 40% syrup at 1 mL/kg of body weight per day (the dose was adjustable according to the patient’s condition and need). At weeks 0, 2, 4, and 6, a checklist containing questions about children’s constipation was completed by the researcher, and the data were analyzed by SPSS version 24. Results: Changes in the frequency of abdominal pain at fourth times 0, 2, 4, and 6 weeks demonstrated statistically significant differences between the two groups (P=0.044), and it was significantly lower the in PEG group; however, the defecation was not statistically significant (P=0.902). After six weeks, the frequency of painful defecation, difficult defecation straining during defecation, and fear of defecation was significantly lower in the group given PEG syrup compared to the fig syrup-receiving group (P=0.001). Conclusion: Overall, PEG syrup was significantly effective in treating chronic functional constipation in children compared to the fig syrup.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121257507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mona Khalednejad, L. Salehi, Sara Pashang, A. Moghimbeigi, Atefeh Nezhadmohamad Nameghi
Background and aims: Cervical cancer is one of the most common cancers of the female reproductive system. Despite the importance of cervical cancer screening in early detection, the uptake of screening is poor. The present study aimed to predict the factors that influence the cervical cancer screening behavior of Iranian women visiting health centers. Methods: This cross-sectional study was performed on 661 women of reproductive age referred to health centers in Karaj, Iran, in 2021, who were selected by convenience sampling. Data collection was performed with a multi-sectional questionnaire designed to collect information about demographic characteristics and constructs of Protection Motivation Theory (PMT) and emotional support. Data analysis was performed using SPSS version 24.0, and AMOS version 24. Results: The mean age of the participants was 38.2±13.77. Most of the participants had a high school diploma and a moderate socioeconomic status. The results showed the direct effect of intention on behavior (β=0.54) and the direct effect of fear on intention (β=-0.66). Perceived self-efficacy had the greatest indirect effect on behavior through intention (β=0.34). All protection motivation constructs except response cost (β=0.06) showed a significant effect on cervical cancer screening behavior. Model fit indices showed the good capability of the extended protection motivation model to predict cervical cancer screening behavior. Conclusion: Perceived self-efficacy is the strongest predictor of cervical cancer screening behavior, and emotional support affects this behavior through self-efficacy and intention. Therefore, it is recommended to pay attention to these factors when designing and planning educational interventions for improving cervical cancer screening behavior.
{"title":"Prediction of the factors influencing cervical cancer screening using the extended protection motivation model: A path analysis","authors":"Mona Khalednejad, L. Salehi, Sara Pashang, A. Moghimbeigi, Atefeh Nezhadmohamad Nameghi","doi":"10.34172/jsums.2022.29","DOIUrl":"https://doi.org/10.34172/jsums.2022.29","url":null,"abstract":"Background and aims: Cervical cancer is one of the most common cancers of the female reproductive system. Despite the importance of cervical cancer screening in early detection, the uptake of screening is poor. The present study aimed to predict the factors that influence the cervical cancer screening behavior of Iranian women visiting health centers. Methods: This cross-sectional study was performed on 661 women of reproductive age referred to health centers in Karaj, Iran, in 2021, who were selected by convenience sampling. Data collection was performed with a multi-sectional questionnaire designed to collect information about demographic characteristics and constructs of Protection Motivation Theory (PMT) and emotional support. Data analysis was performed using SPSS version 24.0, and AMOS version 24. Results: The mean age of the participants was 38.2±13.77. Most of the participants had a high school diploma and a moderate socioeconomic status. The results showed the direct effect of intention on behavior (β=0.54) and the direct effect of fear on intention (β=-0.66). Perceived self-efficacy had the greatest indirect effect on behavior through intention (β=0.34). All protection motivation constructs except response cost (β=0.06) showed a significant effect on cervical cancer screening behavior. Model fit indices showed the good capability of the extended protection motivation model to predict cervical cancer screening behavior. Conclusion: Perceived self-efficacy is the strongest predictor of cervical cancer screening behavior, and emotional support affects this behavior through self-efficacy and intention. Therefore, it is recommended to pay attention to these factors when designing and planning educational interventions for improving cervical cancer screening behavior.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116928964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Shirani –Lepri, K. Shahanipour, R. Monajemi, Golnoosh Rezaeizadeh, Elahe Sadat Mousavi-Abnily
Background and aims: Highly active oxygen causes DNA or protein damage. This study aimed to determine the effect of the extract of three medicinal plants, royal jelly, and metformin on the survival of human dermal fibroblast (HDF) cells under oxidative stress induced by H2 O2 . Methods: Hydroalcoholic extracts were prepared from Nigella sativa, Carum carvi seeds, and Taraxacum officinale flower. The growth curve of HDF cells was plotted in Dulbecco’s modified eagle medium (DMEM). The cells were exposed to H2 O2 stress and treated with different concentrations of the extracts, royal jelly, and metformin. The cells viability was then calorimetrically analyzed during different times in 69-well plates. Results: The exponential growth phase of HDF cells was observed during 24–72-hour growth. High cell survivals were seen during 72 hours of exposure to 25 mg/mL royal jelly (99.13±3.22%), 15 mg/mL C. carvi extracts and N. sativa (97.87±3.25% and 96.22±5.47%, respectively), 10 mg/mL royal jelly (96.14±4.72%), 16 mg/mL metformin (91.23±5.34%), and 8 mg/mL T. officinale (86.31±7.44%), respectively. These results were significantly higher than the results of 48 and 24 hours of exposure to 15 mg/mL N. sativa (P=0.013), 15 mg/mL C. carvi (P=0.019), and 16 mg/mL metformin (P=0.027). Moreover, royal jelly (25 mg/mL) significantly indicated greater effect on the cell survival compared with the highest concentrations of the extracts and metformin at different exposure times (P=0.016-0.032). Conclusion: Royal jelly, N. sativa, and T. officinale extracts revealed remarkable effects on the stressed HDF cells; therefore, they can be proposed for treatment of wounds and burns after clinical analysis.
{"title":"The effect of hydro-alcoholic extracts of Nigella sativa, Carum carvi, Taraxacum officinale, and royal jelly on the survival of HDF cell line under H2O2-induced oxidative stress compared to metformin","authors":"Fatemeh Shirani –Lepri, K. Shahanipour, R. Monajemi, Golnoosh Rezaeizadeh, Elahe Sadat Mousavi-Abnily","doi":"10.34172/jsums.2022.32","DOIUrl":"https://doi.org/10.34172/jsums.2022.32","url":null,"abstract":"Background and aims: Highly active oxygen causes DNA or protein damage. This study aimed to determine the effect of the extract of three medicinal plants, royal jelly, and metformin on the survival of human dermal fibroblast (HDF) cells under oxidative stress induced by H2 O2 . Methods: Hydroalcoholic extracts were prepared from Nigella sativa, Carum carvi seeds, and Taraxacum officinale flower. The growth curve of HDF cells was plotted in Dulbecco’s modified eagle medium (DMEM). The cells were exposed to H2 O2 stress and treated with different concentrations of the extracts, royal jelly, and metformin. The cells viability was then calorimetrically analyzed during different times in 69-well plates. Results: The exponential growth phase of HDF cells was observed during 24–72-hour growth. High cell survivals were seen during 72 hours of exposure to 25 mg/mL royal jelly (99.13±3.22%), 15 mg/mL C. carvi extracts and N. sativa (97.87±3.25% and 96.22±5.47%, respectively), 10 mg/mL royal jelly (96.14±4.72%), 16 mg/mL metformin (91.23±5.34%), and 8 mg/mL T. officinale (86.31±7.44%), respectively. These results were significantly higher than the results of 48 and 24 hours of exposure to 15 mg/mL N. sativa (P=0.013), 15 mg/mL C. carvi (P=0.019), and 16 mg/mL metformin (P=0.027). Moreover, royal jelly (25 mg/mL) significantly indicated greater effect on the cell survival compared with the highest concentrations of the extracts and metformin at different exposure times (P=0.016-0.032). Conclusion: Royal jelly, N. sativa, and T. officinale extracts revealed remarkable effects on the stressed HDF cells; therefore, they can be proposed for treatment of wounds and burns after clinical analysis.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134234586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farshad Yadollahi, Shahriyar Salehitali, Ahmad Hormaty, F. Yadollahi
Background and aims: Acute respiratory distress syndrome (ARDS) treatment is supportive, and there is no currently approved treatment for it. This study, therefore, aimed to investigate the effect of endotracheal administration of N-acetyl cysteine (NAC) and heparin on the level of secretion and partial thromboplastin time (PTT) in ARDS patients under mechanical ventilation. Methods: In this clinical trial study, 70 patients aged over 18 years (30 women and 40 men) admitted to the intensive care unit were randomly selected following the allocation rule and then divided into two groups (intervention and control). In addition to the routine and available treatments in the ward given to the patients in both groups, the control group also received 10 mL of normal saline every six hours through the endotracheal route, while the intervention group received 500 units of heparin plus 200 mg of NAC dissolved in 10 mL of normal saline every six hours through the same administration route. Results: The mean and standard deviation levels of PTT in the control and intervention groups were 30.3743 ± 7.78008 and 32.2286 ± 8.31047, respectively, with no significant difference (P>0.05); the volume of secretion on days 1-3 was not significantly different between the two groups, but the difference was statistically significant from day 4 onwards (P<0.05). Conclusion: Taking the combination of NAC and heparin through the endotracheal route was effective in reducing pulmonary secretion, and may have been considered a considerable positive step in providing patients suffering from acute respiratory failure and under mechanical ventilation with supportive care. However, it is recommended that further clinical studies be conducted before arriving at any definitive conclusion.
{"title":"The effect of endotracheal administration of N-acetyl cysteine and heparin on the level of secretion and partial thromboplastin time in acute respiratory distress syndrome patients under mechanical ventilation: A randomized clinical trial study","authors":"Farshad Yadollahi, Shahriyar Salehitali, Ahmad Hormaty, F. Yadollahi","doi":"10.34172/jsums.2022.19","DOIUrl":"https://doi.org/10.34172/jsums.2022.19","url":null,"abstract":"Background and aims: Acute respiratory distress syndrome (ARDS) treatment is supportive, and there is no currently approved treatment for it. This study, therefore, aimed to investigate the effect of endotracheal administration of N-acetyl cysteine (NAC) and heparin on the level of secretion and partial thromboplastin time (PTT) in ARDS patients under mechanical ventilation. Methods: In this clinical trial study, 70 patients aged over 18 years (30 women and 40 men) admitted to the intensive care unit were randomly selected following the allocation rule and then divided into two groups (intervention and control). In addition to the routine and available treatments in the ward given to the patients in both groups, the control group also received 10 mL of normal saline every six hours through the endotracheal route, while the intervention group received 500 units of heparin plus 200 mg of NAC dissolved in 10 mL of normal saline every six hours through the same administration route. Results: The mean and standard deviation levels of PTT in the control and intervention groups were 30.3743 ± 7.78008 and 32.2286 ± 8.31047, respectively, with no significant difference (P>0.05); the volume of secretion on days 1-3 was not significantly different between the two groups, but the difference was statistically significant from day 4 onwards (P<0.05). Conclusion: Taking the combination of NAC and heparin through the endotracheal route was effective in reducing pulmonary secretion, and may have been considered a considerable positive step in providing patients suffering from acute respiratory failure and under mechanical ventilation with supportive care. However, it is recommended that further clinical studies be conducted before arriving at any definitive conclusion.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121068660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: This study was conducted to compare the effects of two compounds ropivacaine and lidocaine associated with epinephrine on the heart rate, blood pressure, and bleeding rate in children undergoing general anesthesia for the cleft palate repair surgery. Methods: In this study, 30 children candidates for cleft palate surgery who were referred to Mofid Children’s Hospital, affiliated with Shahid Beheshti University of Medical Sciences in 2021, were included by using the convenience sampling method. The patients were randomly divided into two groups. Group 1 was treated with ropivacaine and group 2 was treated with lidocaine along with epinephrine. The data were analyzed by the SPSS, version 22. Results: In total, no statistically significant difference was found between the two groups in terms of vital signs of blood pressure and heart rate in the 10 stages studied (P<0.05). There was no difference between the two groups in the trend of the changes in blood pressure (P=0.381) and heart rate (P=0.940). However, the trend of blood pressure and heart rate had significantly changed during the study in both groups individually (P<0.001). The bleeding rate (suction) (P<0.001) and the weight of gases used (P=0.003) in the second group were significantly higher than in the first group. Conclusion: No difference was found between the effects of ropivacaine and lidocaine combined with epinephrine on the heart rate and blood pressure in patients who were candidates for the cleft palate surgery, but the rate of bleeding (suction) in the second group was more than the first group.
{"title":"Comparing the effects of ropivacaine and lidocaine associated with epinephrine on the heart rate, blood pressure, and amount of bleeding in patients candidate for cleft palate repair: A randomized clinical trial","authors":"A. Eghbali, B. Khoram","doi":"10.34172/jsums.2022.18","DOIUrl":"https://doi.org/10.34172/jsums.2022.18","url":null,"abstract":"Background and aims: This study was conducted to compare the effects of two compounds ropivacaine and lidocaine associated with epinephrine on the heart rate, blood pressure, and bleeding rate in children undergoing general anesthesia for the cleft palate repair surgery. Methods: In this study, 30 children candidates for cleft palate surgery who were referred to Mofid Children’s Hospital, affiliated with Shahid Beheshti University of Medical Sciences in 2021, were included by using the convenience sampling method. The patients were randomly divided into two groups. Group 1 was treated with ropivacaine and group 2 was treated with lidocaine along with epinephrine. The data were analyzed by the SPSS, version 22. Results: In total, no statistically significant difference was found between the two groups in terms of vital signs of blood pressure and heart rate in the 10 stages studied (P<0.05). There was no difference between the two groups in the trend of the changes in blood pressure (P=0.381) and heart rate (P=0.940). However, the trend of blood pressure and heart rate had significantly changed during the study in both groups individually (P<0.001). The bleeding rate (suction) (P<0.001) and the weight of gases used (P=0.003) in the second group were significantly higher than in the first group. Conclusion: No difference was found between the effects of ropivacaine and lidocaine combined with epinephrine on the heart rate and blood pressure in patients who were candidates for the cleft palate surgery, but the rate of bleeding (suction) in the second group was more than the first group.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128493259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Paknia, Niloofar Parchami, Negar Nasry, H. Mohabatkar
Background and aims: Curcumin or diferuloylmethane is derived from ferulic acid. This herbal compound has a particular chemical structure and various biological/medical properties. The functional groups in the curcumin structure and its analogs are involved in the formation of specific biological activities. This natural compound has high bioactivity, as well as the potential to treat diseases such as cancer, Alzheimer’s, diabetes, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Considering the spread of infectious diseases and cancers in recent years, as well as an increase in drug resistance and side effects, providing effective and available treatments is necessary. Methods: This review explained the chemical structure of curcumin and covered its biological properties, including anti-inflammation, antioxidant, anti-cancer, neuroprotective, anti-diabetic, and anti-SARS-CoV-2 activities. Scientific databases were studied to gather the required information. Results: Curcumin affected several molecular pathways, including activating transcription factors, cell growth factors, anti-inflammatory agents, protein kinases, cytokines, and apoptotic pathway factors. Thus, it had beneficial therapeutic effects on health. Conclusion: By targeting a wide range of molecular mechanisms, curcumin has the potential to treat various diseases. Knowledge of curcumin’s pharmacological/biological activities and its action mechanisms can enhance the applications of curcumin as a potentially bioactive and therapeutic compound.
{"title":"Therapeutic activities and biological effects of curcumin, as a natural multi-target compound, on human health: A minireview","authors":"Fatemeh Paknia, Niloofar Parchami, Negar Nasry, H. Mohabatkar","doi":"10.34172/jsums.2022.24","DOIUrl":"https://doi.org/10.34172/jsums.2022.24","url":null,"abstract":"Background and aims: Curcumin or diferuloylmethane is derived from ferulic acid. This herbal compound has a particular chemical structure and various biological/medical properties. The functional groups in the curcumin structure and its analogs are involved in the formation of specific biological activities. This natural compound has high bioactivity, as well as the potential to treat diseases such as cancer, Alzheimer’s, diabetes, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Considering the spread of infectious diseases and cancers in recent years, as well as an increase in drug resistance and side effects, providing effective and available treatments is necessary. Methods: This review explained the chemical structure of curcumin and covered its biological properties, including anti-inflammation, antioxidant, anti-cancer, neuroprotective, anti-diabetic, and anti-SARS-CoV-2 activities. Scientific databases were studied to gather the required information. Results: Curcumin affected several molecular pathways, including activating transcription factors, cell growth factors, anti-inflammatory agents, protein kinases, cytokines, and apoptotic pathway factors. Thus, it had beneficial therapeutic effects on health. Conclusion: By targeting a wide range of molecular mechanisms, curcumin has the potential to treat various diseases. Knowledge of curcumin’s pharmacological/biological activities and its action mechanisms can enhance the applications of curcumin as a potentially bioactive and therapeutic compound.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116499949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Yahyaie, E. Salehi, Majid Morovati-Sharifabad, F. Sarkargar, M. S. Heydarnejad, G. Pourghanbari
Background and aims: Ovarian cancer is the second most common cause of death in Iran. A reduction in vitamin D production has been associated with an increased risk for ovarian cancer in many studies. Human epididymis protein 4 (HE4) is known as one of the most accurate tumor markers for the analysis of ovarian epithelial cancer illness or progression. The expression of the gene increases in many types of ovarian cancer. The aim of this study was to find whether vitamin D has anticancer effects on the viability of HE4 gene expression. Methods: The human ovarian cancer cell line (A2780S) was cultured in an RPMI-1640 medium. To determine the inhibitory concentration (IC50), the cells were treated with various concentrations of vitamin D and then incubated for 24, 48, and 72 hours. The effect of drugs on the expression of HE4 gene modification was measured and evaluated using the real-time polymerase chain reaction and a 2-ΔΔCT method, respectively. Results: The IC50 value for vitamin D was 0.359 μM, and the maximum death rates were observed after 24 hours (56.20 ± 5.79). The HE4 gene expression treated with vitamin D increased compared with the cells in the control group (Fold change > 1). Conclusion: Vitamin D decreases the viability of A2780S cells, whereas the expression of the HE4 gene is improved in cells treated with vitamin D compared to control cells, indicating that vitamin D may be unable to modify A2780S cells.
{"title":"An investigation of the anti-cancer effects of vitamin D on the expression of HE4 gene and the viability of ovarian cancer cell line A2780S","authors":"Maryam Yahyaie, E. Salehi, Majid Morovati-Sharifabad, F. Sarkargar, M. S. Heydarnejad, G. Pourghanbari","doi":"10.34172/jsums.2022.22","DOIUrl":"https://doi.org/10.34172/jsums.2022.22","url":null,"abstract":"Background and aims: Ovarian cancer is the second most common cause of death in Iran. A reduction in vitamin D production has been associated with an increased risk for ovarian cancer in many studies. Human epididymis protein 4 (HE4) is known as one of the most accurate tumor markers for the analysis of ovarian epithelial cancer illness or progression. The expression of the gene increases in many types of ovarian cancer. The aim of this study was to find whether vitamin D has anticancer effects on the viability of HE4 gene expression. Methods: The human ovarian cancer cell line (A2780S) was cultured in an RPMI-1640 medium. To determine the inhibitory concentration (IC50), the cells were treated with various concentrations of vitamin D and then incubated for 24, 48, and 72 hours. The effect of drugs on the expression of HE4 gene modification was measured and evaluated using the real-time polymerase chain reaction and a 2-ΔΔCT method, respectively. Results: The IC50 value for vitamin D was 0.359 μM, and the maximum death rates were observed after 24 hours (56.20 ± 5.79). The HE4 gene expression treated with vitamin D increased compared with the cells in the control group (Fold change > 1). Conclusion: Vitamin D decreases the viability of A2780S cells, whereas the expression of the HE4 gene is improved in cells treated with vitamin D compared to control cells, indicating that vitamin D may be unable to modify A2780S cells.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115835494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Ahani, M. Chorami, T. Sharifi, A. Ghazanfari, Iman Adibi Sedeh
Background and aims: The present study aimed to determine the effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis (MS). Methods: In this quasi-experimental study, among women with MS in Isfahan province who had medical records in Ayatollah Kashani Hospital and Isfahan MS Center, 150 female patients were enrolled by convenience sampling and screened by Sexual Quality of Life-Female (SQOL-F). After screening, 46 patients, whose quality of sexual life score was lower than the mean score of 63, were randomly assigned to experimental and control groups, each comprising 23 patients. The experimental group received the Pythagorean self-awareness intervention, while the control group received no intervention. Both groups were assessed at pre-test, post-test, and two follow-up stages. The data were analyzed by multivariate analysis of covariance (MANCOVA). Results: The results revealed that the quality of sexual life of the experimental group improved after the intervention (P<0.001). Compared to the pre-test, a significant difference was observed in its components, namely, psychosexual feelings, sexual and relationship satisfaction, self-worthlessness, and sexual repression (P<0.001). Conclusion: It seems that Pythagorean self-awareness intervention effectively improves the quality of sexual life of women with MS. In addition to the overall improvement in the quality of sexual life, a significant difference was observed in its components compared to the pre-test after the intervention. Therefore, it is essential to plan psychological interventions to improve these women’s quality of sexual life.
{"title":"The effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis","authors":"Leila Ahani, M. Chorami, T. Sharifi, A. Ghazanfari, Iman Adibi Sedeh","doi":"10.34172/jsums.2022.21","DOIUrl":"https://doi.org/10.34172/jsums.2022.21","url":null,"abstract":"Background and aims: The present study aimed to determine the effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis (MS). Methods: In this quasi-experimental study, among women with MS in Isfahan province who had medical records in Ayatollah Kashani Hospital and Isfahan MS Center, 150 female patients were enrolled by convenience sampling and screened by Sexual Quality of Life-Female (SQOL-F). After screening, 46 patients, whose quality of sexual life score was lower than the mean score of 63, were randomly assigned to experimental and control groups, each comprising 23 patients. The experimental group received the Pythagorean self-awareness intervention, while the control group received no intervention. Both groups were assessed at pre-test, post-test, and two follow-up stages. The data were analyzed by multivariate analysis of covariance (MANCOVA). Results: The results revealed that the quality of sexual life of the experimental group improved after the intervention (P<0.001). Compared to the pre-test, a significant difference was observed in its components, namely, psychosexual feelings, sexual and relationship satisfaction, self-worthlessness, and sexual repression (P<0.001). Conclusion: It seems that Pythagorean self-awareness intervention effectively improves the quality of sexual life of women with MS. In addition to the overall improvement in the quality of sexual life, a significant difference was observed in its components compared to the pre-test after the intervention. Therefore, it is essential to plan psychological interventions to improve these women’s quality of sexual life.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123446577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahrzad Mirmojarabian, A. Karimi, Z. Lorigooini, Fatemeh Javadi-Farsani, A. Soltani, M. Moradi
Background and aims: The lack of effective antiviral drugs for adenoviruses is one of the most important problems in this area. The aim of this study was to investigate the phytochemical properties and antiviral effect of the green tea extract (GTE) on adenovirus in HEp2 cells in vitro. Methods: In this experimental study, dried leaves of green tea were extracted by maceration. Total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity of the extract were measured by Folin-Ciocalteu, aluminum chloride, and 2,2-diphenyl-1- picrylhydrazyl (DPPH) colorimetric methods, respectively. The amounts of some phenolic compounds in the extract were also determined using high-performance liquid chromatography. The toxicity of the extract on Hep2 cells and antiviral activity of the extract on adenovirus were assessed by the MTT colorimetric method. The half-maximum cytotoxicity concentration (CC50) and the 50% inhibitory concentration (IC50) of the extract were calculated as well. Results: Phytochemical investigations showed that the IC50 of DPPH radical was 42.1 ± 3.2 μg/mL compared with butylated hydroxytoluene (IC50 of 33.5 ± 3.67 μg/mL). The TPC and TFC of the extract were 74.2 mg GAE/g and 16.3 mg RE/g of the dry extract, respectively. The extract demonstrated the highest amounts of syringic acid, gallic acid, 3,4-dihydroxybenzoic acid, and rutin levels (67.27, 20.12, 7.39, and 2.97 mg/g DW, respectively). Based on the results of cell culture, the CC50 and IC50 of GTE were 103.3 μg/mL and 25.16 μg/mL, respectively. Conclusion: GTE with phenolic and flavonoid compounds can exert dose-dependent inhibitory effects on adenoviruses.
{"title":"Phytochemical properties and antiviral effect of green tea (Camellia sinensis) extract on adenovirus in vitro","authors":"Shahrzad Mirmojarabian, A. Karimi, Z. Lorigooini, Fatemeh Javadi-Farsani, A. Soltani, M. Moradi","doi":"10.34172/jsums.2022.17","DOIUrl":"https://doi.org/10.34172/jsums.2022.17","url":null,"abstract":"Background and aims: The lack of effective antiviral drugs for adenoviruses is one of the most important problems in this area. The aim of this study was to investigate the phytochemical properties and antiviral effect of the green tea extract (GTE) on adenovirus in HEp2 cells in vitro. Methods: In this experimental study, dried leaves of green tea were extracted by maceration. Total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity of the extract were measured by Folin-Ciocalteu, aluminum chloride, and 2,2-diphenyl-1- picrylhydrazyl (DPPH) colorimetric methods, respectively. The amounts of some phenolic compounds in the extract were also determined using high-performance liquid chromatography. The toxicity of the extract on Hep2 cells and antiviral activity of the extract on adenovirus were assessed by the MTT colorimetric method. The half-maximum cytotoxicity concentration (CC50) and the 50% inhibitory concentration (IC50) of the extract were calculated as well. Results: Phytochemical investigations showed that the IC50 of DPPH radical was 42.1 ± 3.2 μg/mL compared with butylated hydroxytoluene (IC50 of 33.5 ± 3.67 μg/mL). The TPC and TFC of the extract were 74.2 mg GAE/g and 16.3 mg RE/g of the dry extract, respectively. The extract demonstrated the highest amounts of syringic acid, gallic acid, 3,4-dihydroxybenzoic acid, and rutin levels (67.27, 20.12, 7.39, and 2.97 mg/g DW, respectively). Based on the results of cell culture, the CC50 and IC50 of GTE were 103.3 μg/mL and 25.16 μg/mL, respectively. Conclusion: GTE with phenolic and flavonoid compounds can exert dose-dependent inhibitory effects on adenoviruses.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116001382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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