Zohreh Shahsavari Googhari, F. Hafezi, P. Asgari, A. Heidari
Background and aims: Subjective well-being as a major prerequisite of health ensures mental and physical health, a long life, happiness, improved quality of life, and higher socioeconomic indices. The present study aimed to investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) and acceptance and commitment therapy (ACT) on subjective well-being, psychological distress, and emotion regulation in medical science students. Methods: The statistical population of this semi-experimental comprised all female students at Kerman University of Medical Sciences (Iran) in the academic year of 2019-2020. Forty-five students referring to the university counseling center were selected as the sample of the study using convenience sampling and randomly divided into two experimental groups and a control group (n=15 per group). The first and second experimental groups underwent eight 90- and 45-sessions (twice a week) of MBCT and of ACT, respectively. The research instruments included the Subjective Well-being Scale (SWS), the Depression, Anxiety, and Stress Scale, and the Cognitive Emotion Regulation Questionnaire. Results: The results showed that MBCT and ACT were effective in improving the components of subjective well-being and emotion regulation in medical students (P<0.001). Moreover, MBCT and ACT significantly reduced the post-test scores of psychological distress subscales in the experimental group compared to the control group (P<0.001). Finally, no difference was observed between the two therapies in terms of effectiveness. Conclusion: According to the results, MBCT and ACT effectively promoted female students’ subjective well-being and emotion regulation and alleviated their psychological distress.
{"title":"The effectiveness of mindfulness-based cognitive therapy and acceptance and commitment therapy on medical science students’ subjective well-being, psychological distress, and emotion regulation","authors":"Zohreh Shahsavari Googhari, F. Hafezi, P. Asgari, A. Heidari","doi":"10.34172/jsums.2022.07","DOIUrl":"https://doi.org/10.34172/jsums.2022.07","url":null,"abstract":"Background and aims: Subjective well-being as a major prerequisite of health ensures mental and physical health, a long life, happiness, improved quality of life, and higher socioeconomic indices. The present study aimed to investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) and acceptance and commitment therapy (ACT) on subjective well-being, psychological distress, and emotion regulation in medical science students. Methods: The statistical population of this semi-experimental comprised all female students at Kerman University of Medical Sciences (Iran) in the academic year of 2019-2020. Forty-five students referring to the university counseling center were selected as the sample of the study using convenience sampling and randomly divided into two experimental groups and a control group (n=15 per group). The first and second experimental groups underwent eight 90- and 45-sessions (twice a week) of MBCT and of ACT, respectively. The research instruments included the Subjective Well-being Scale (SWS), the Depression, Anxiety, and Stress Scale, and the Cognitive Emotion Regulation Questionnaire. Results: The results showed that MBCT and ACT were effective in improving the components of subjective well-being and emotion regulation in medical students (P<0.001). Moreover, MBCT and ACT significantly reduced the post-test scores of psychological distress subscales in the experimental group compared to the control group (P<0.001). Finally, no difference was observed between the two therapies in terms of effectiveness. Conclusion: According to the results, MBCT and ACT effectively promoted female students’ subjective well-being and emotion regulation and alleviated their psychological distress.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"195 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120866604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Biophysical evaluation of fetal profile and movements is a useful tool for assessing fetal health, which even has significant effects on neonatal health. This study aimed to compare the biophysical parameters of the profile – fetal movement index, in particular – before and after corticosteroid administration in two groups receiving dexamethasone and betamethasone. Methods: In this descriptive/analytical study, 200 patients diagnosed with preterm delivery and admitted to the gynecology section of Hajar Hospital in Shahrekord in 2016 were investigated. Their demographic findings and medical histories were collected using a checklist form. Then their biophysical profiles 24 to 48 hours after corticosteroid administration were assessed. Finally, the data were analyzed by SPSS v. 18 software using t test, chi-square and Fisher exact test. Results: According to our study results, there was a significant difference in fetal movements before and after receiving corticosteroids, and the decrease in the percentage of movements was greater in the betamethasone group (P<0.001). Also, the biophysical profile was significantly different in the dexamethasone group compared to the betamethasone group (P<0.001). No significant difference was found between two groups in terms of fetal respiration and non-stress test (NST) before and after receiving corticosteroids (P=0.47 and P=0.65, respectively). Conclusion: Dexamethasone administration had less effect on reducing fetal movement index than betamethasone administration. As the result, the biophysical profile was significantly different in the dexamethasone group compared to the betamethasone one.
背景和目的:胎儿外形和运动的生物物理评价是评估胎儿健康的有用工具，甚至对新生儿健康有重要影响。本研究旨在比较两组接受地塞米松和倍他米松治疗前后的生物物理参数，特别是胎儿运动指数。方法:采用描述性/分析性研究方法，对2016年在Shahrekord市Hajar医院妇科就诊的200例诊断为早产的患者进行调查。他们的人口统计结果和病史是用核对表收集的。然后在皮质类固醇给药后24至48小时评估他们的生物物理特征。最后，采用SPSS v. 18软件对数据进行t检验、卡方检验和Fisher精确检验。结果:我们的研究结果显示，接受皮质类固醇治疗前后胎儿运动有显著差异，且倍他米松组胎儿运动百分比下降幅度更大(P<0.001)。与倍他米松组相比，地塞米松组的生物物理特征也有显著差异(P<0.001)。两组胎儿呼吸和非应激试验(NST)在使用糖皮质激素前后无显著差异(P=0.47和P=0.65)。结论:地塞米松对胎儿运动指数的影响小于倍他米松。结果，与倍他米松组相比，地塞米松组的生物物理特征有显著差异。
{"title":"Betamethasone versus dexamethasone on the fetal movement index in the women with preterm labor: A cross-sectional study","authors":"A. Taheri, S. Shabanian, M. Khosravi, S. Kheiri","doi":"10.34172/jsums.2022.06","DOIUrl":"https://doi.org/10.34172/jsums.2022.06","url":null,"abstract":"Background and aims: Biophysical evaluation of fetal profile and movements is a useful tool for assessing fetal health, which even has significant effects on neonatal health. This study aimed to compare the biophysical parameters of the profile – fetal movement index, in particular – before and after corticosteroid administration in two groups receiving dexamethasone and betamethasone. Methods: In this descriptive/analytical study, 200 patients diagnosed with preterm delivery and admitted to the gynecology section of Hajar Hospital in Shahrekord in 2016 were investigated. Their demographic findings and medical histories were collected using a checklist form. Then their biophysical profiles 24 to 48 hours after corticosteroid administration were assessed. Finally, the data were analyzed by SPSS v. 18 software using t test, chi-square and Fisher exact test. Results: According to our study results, there was a significant difference in fetal movements before and after receiving corticosteroids, and the decrease in the percentage of movements was greater in the betamethasone group (P<0.001). Also, the biophysical profile was significantly different in the dexamethasone group compared to the betamethasone group (P<0.001). No significant difference was found between two groups in terms of fetal respiration and non-stress test (NST) before and after receiving corticosteroids (P=0.47 and P=0.65, respectively). Conclusion: Dexamethasone administration had less effect on reducing fetal movement index than betamethasone administration. As the result, the biophysical profile was significantly different in the dexamethasone group compared to the betamethasone one.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116576310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: In the phenylalanine hydroxylase (PAH) gene, various mutations are mainly responsible for phenylketonuria (PKU). After thalassemia, PKU is considered as the most common autosomal recessive disease among Iranian population. Therefore, identifying the mutations that cause the disease in this population is of great importance. This study aimed to identify exon 5 mutations of PAH gene in PKU patients from Golestan, the northern province of Iran, and compare these mutations with those onesa found by studies carried out in other parts of the country. Methods: During a one-year period, 25 unrelated PKU patients aged 1-23 years and from different parts of Golestan province were included in the study. Then, their genomic DNAs were extracted from their blood samples and PCR-sequencing method was used to identify the mutations. The sequencing results were analyzed using Chromas and CLC Main Workbench v3.5 software. Results: In this study, R158Q mutation was detected with a frequency of 6%. This mutation was homozygous in one PKU patient, but it was heterozygous in another one. These patients had cPKU phenotype. Conclusion: Evaluation of mutations proved to be a useful technique for molecular diagnosis of PKU and identification of disease carriers in the given population. Taking into account the fact that only one exon of PAH gene was explored in this study, however, it is recommended that further studies be conducted to investigate other exons in order for obtaining the complete mutation spectrum of this gene in PKU patients in Golestan province.
背景与目的:在苯丙氨酸羟化酶(PAH)基因中，各种突变是导致苯丙酮尿症(PKU)的主要原因。PKU被认为是伊朗人群中最常见的常染色体隐性遗传病，仅次于地中海贫血。因此，在这一人群中确定导致疾病的突变是非常重要的。本研究旨在鉴定来自伊朗北部省份Golestan的PKU患者的PAH基因外显子5突变，并将这些突变与在该国其他地区进行的研究中发现的突变进行比较。方法:选取来自Golestan省不同地区的25例无关联PKU患者，年龄1-23岁，为期一年。然后，从他们的血液样本中提取基因组dna，并使用pcr测序方法鉴定突变。使用Chromas和CLC Main Workbench v3.5软件对测序结果进行分析。结果:本研究中检测到R158Q突变，频率为6%。该突变在一名PKU患者中为纯合子，但在另一名患者中为杂合子。这些患者具有cPKU表型。结论:基因突变评价是PKU分子诊断和确定特定人群疾病携带者的有效方法。但考虑到本研究仅探索了PAH基因的一个外显子，建议进一步研究其他外显子，以获得该基因在Golestan省PKU患者中的完整突变谱。
{"title":"Mutation analysis of exon 5 of PAH gene in phenylketonuria patients from Golestan Province, Iran","authors":"Mehrnaz Zarinkoob, Zeinab Khazaei Koohpar","doi":"10.34172/jsums.2022.03","DOIUrl":"https://doi.org/10.34172/jsums.2022.03","url":null,"abstract":"Background and aims: In the phenylalanine hydroxylase (PAH) gene, various mutations are mainly responsible for phenylketonuria (PKU). After thalassemia, PKU is considered as the most common autosomal recessive disease among Iranian population. Therefore, identifying the mutations that cause the disease in this population is of great importance. This study aimed to identify exon 5 mutations of PAH gene in PKU patients from Golestan, the northern province of Iran, and compare these mutations with those onesa found by studies carried out in other parts of the country. Methods: During a one-year period, 25 unrelated PKU patients aged 1-23 years and from different parts of Golestan province were included in the study. Then, their genomic DNAs were extracted from their blood samples and PCR-sequencing method was used to identify the mutations. The sequencing results were analyzed using Chromas and CLC Main Workbench v3.5 software. Results: In this study, R158Q mutation was detected with a frequency of 6%. This mutation was homozygous in one PKU patient, but it was heterozygous in another one. These patients had cPKU phenotype. Conclusion: Evaluation of mutations proved to be a useful technique for molecular diagnosis of PKU and identification of disease carriers in the given population. Taking into account the fact that only one exon of PAH gene was explored in this study, however, it is recommended that further studies be conducted to investigate other exons in order for obtaining the complete mutation spectrum of this gene in PKU patients in Golestan province.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126469252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Raeisi, Z. Rezaei, Zahra Habibi, M. Salimi, H. Raeisi
Background and aims: COVID-19 is a pandemic and infectious disease with high morbidity and mortality rates as well as a global spread. This study aimed to investigate the clinical outcomes for patients afflicted with COVID-19 and treated with remdesivir. Methods: In this clinical trial study, patients with severe COVID-19 confirmed by molecular testing and hospitalized at Hajar Hospital of Shahrekord in Iran were divided into standard care group (including 52 patients) and standard + remdesivir group (including 51 patients). The patients were examined for clinical symptoms, laboratory data, as well as mortality and recovery rates during the treatment period. Then the data were analyzed by SPSS version 23 using chi-square, independent t-test and repeated-measures ANOVA. Result: Clinical and laboratory monitoring on days 5, 10, and 14 showed that there was no significant difference between two groups (P>0.05). In addition, there was no significant difference between the two groups in terms of hospitalization duration and ICU rate (58.8% versus 51.9%, P=0.48). The trend of Lymph count and platelet decreased significantly in the standard group (P=0.003, P=0.04, and P=0.03, respectively). Conclusion: Patients with severe COVID-19 were investigated and it was concluded that remdesivir produced no improvement in the remdesivir group compared to the standard group.
背景和目的:COVID-19是一种高发病率和高死亡率的大流行传染病，具有全球传播性。本研究旨在探讨使用瑞德西韦治疗的COVID-19患者的临床结果。方法:本临床试验研究将伊朗Shahrekord Hajar医院经分子检测确诊的重症COVID-19患者分为标准治疗组(52例)和标准+瑞德西韦组(51例)。检查患者的临床症状、实验室数据以及治疗期间的死亡率和康复率。采用SPSS第23版对数据进行分析，采用卡方、独立t检验和重复测量方差分析。结果:第5、10、14天临床及实验室监测结果显示，两组间比较差异无统计学意义(P>0.05)。两组住院时间和ICU使用率比较，差异无统计学意义(58.8% vs 51.9%， P=0.48)。标准组淋巴计数、血小板变化趋势明显降低(P=0.003、P=0.04、P=0.03)。结论:对重症COVID-19患者进行调查，结论是与标准组相比，瑞德西韦组没有改善。
{"title":"Clinical course and disease outcome in patients with severe COVID-19 receiving remdesivir","authors":"A. Raeisi, Z. Rezaei, Zahra Habibi, M. Salimi, H. Raeisi","doi":"10.34172/jsums.2022.02","DOIUrl":"https://doi.org/10.34172/jsums.2022.02","url":null,"abstract":"Background and aims: COVID-19 is a pandemic and infectious disease with high morbidity and mortality rates as well as a global spread. This study aimed to investigate the clinical outcomes for patients afflicted with COVID-19 and treated with remdesivir. Methods: In this clinical trial study, patients with severe COVID-19 confirmed by molecular testing and hospitalized at Hajar Hospital of Shahrekord in Iran were divided into standard care group (including 52 patients) and standard + remdesivir group (including 51 patients). The patients were examined for clinical symptoms, laboratory data, as well as mortality and recovery rates during the treatment period. Then the data were analyzed by SPSS version 23 using chi-square, independent t-test and repeated-measures ANOVA. Result: Clinical and laboratory monitoring on days 5, 10, and 14 showed that there was no significant difference between two groups (P>0.05). In addition, there was no significant difference between the two groups in terms of hospitalization duration and ICU rate (58.8% versus 51.9%, P=0.48). The trend of Lymph count and platelet decreased significantly in the standard group (P=0.003, P=0.04, and P=0.03, respectively). Conclusion: Patients with severe COVID-19 were investigated and it was concluded that remdesivir produced no improvement in the remdesivir group compared to the standard group.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"112 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134096898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samira Zaheri Abdehvand, Khosro Jalali Dehkordi, F. Taghian
Background and aims: The activation of inflammatory reactions is essential immediately after the onset of myocardial infarction (MI). On the other hand, the path of inflammatory activators should be controlled to prevent the recurrence of MI. In this vein, the aim of this study was to examine the effect of eight weeks of interval training and quercetin nanoliposome consumption on nuclear factor kappa B (NF-κB) and fibroblast growth factor 2 (FGF-2) gene expression in the heart tissue of MI rats. Methods: In this experimental study, 30 male rats, aged approximately 6-8 weeks, were randomly divided into five groups including MI + training, MI + supplement, MI + training + supplement, healthy control, and MI. The MI was induced by the subcutaneous injection of isoprenaline hydrochloride at a dose of 80 mg/kg. Quercetin was daily administered at a dose of 0.25 mg for 8 weeks, and interval training was performed 5 days a week. NF-κB and FGF-2 gene expressions were measured by the real-time polymerase chain reaction. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P<0.05). Results: Training significantly increased NF-κB gene expression in the MI+ training, MI + supplement, and MI + training + supplement groups (P=0.001) while significantly decreasing FGF-2 gene expression in the MI group (P=0.04). Conclusion: Interval training may prevent the negative effects of MI by reducing pro-inflammatory gene expression in the heart tissue, leading to improved cardiovascular function and the prevention of this disease.
{"title":"The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-2 gene expression in the heart tissue of myocardial infarction rats","authors":"Samira Zaheri Abdehvand, Khosro Jalali Dehkordi, F. Taghian","doi":"10.34172/jsums.2022.05","DOIUrl":"https://doi.org/10.34172/jsums.2022.05","url":null,"abstract":"Background and aims: The activation of inflammatory reactions is essential immediately after the onset of myocardial infarction (MI). On the other hand, the path of inflammatory activators should be controlled to prevent the recurrence of MI. In this vein, the aim of this study was to examine the effect of eight weeks of interval training and quercetin nanoliposome consumption on nuclear factor kappa B (NF-κB) and fibroblast growth factor 2 (FGF-2) gene expression in the heart tissue of MI rats. Methods: In this experimental study, 30 male rats, aged approximately 6-8 weeks, were randomly divided into five groups including MI + training, MI + supplement, MI + training + supplement, healthy control, and MI. The MI was induced by the subcutaneous injection of isoprenaline hydrochloride at a dose of 80 mg/kg. Quercetin was daily administered at a dose of 0.25 mg for 8 weeks, and interval training was performed 5 days a week. NF-κB and FGF-2 gene expressions were measured by the real-time polymerase chain reaction. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P<0.05). Results: Training significantly increased NF-κB gene expression in the MI+ training, MI + supplement, and MI + training + supplement groups (P=0.001) while significantly decreasing FGF-2 gene expression in the MI group (P=0.04). Conclusion: Interval training may prevent the negative effects of MI by reducing pro-inflammatory gene expression in the heart tissue, leading to improved cardiovascular function and the prevention of this disease.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122797570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Nosrati, Mehdi Banitalebi-Dhkordi, M. Khodaei, E. Sharifi, Shiva Asadpour, K. Mansouri, Mostafa Soleimannejad
Background and aims: The presence of an appropriate scaffold at the wound site could significantly improve the healing process. In this study, we aimed to prepare a biomimetic nanocomposite scaffold composed of chitosan, gelatin, and 58S bioglass nanoparticles for skin tissue engineering. Methods: The nanocomposite scaffolds composed of chitosan, gelatin, and 58S bioglass nanoparticles were fabricated through electrospinning process. Then the cell viability assay was performed in order to evaluate the biological properties of the membranes. The optimum concentration of bioglass nanoparticles was determined for further studies. In vitro characterization was also performed to evaluate physicochemical properties of the scaffolds. Results: The chitosan/gelatin scaffold containing 2% of 58S bioglass nanoparticles showed no cell toxicity, and the dermal fibroblasts were found capable of proliferation on the membrane. The in vitro results obtained from the scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and porosity tests demonstrated the appropriate properties of the membrane as a scaffold for skin regeneration. Conclusions: It was concluded that a chitosan-gelatin membrane containing 2% of 58S bioglass nanoparticles had the potential to function as a scaffold to accelerate wound healing due to its suitable properties, such as high porosity, high surface/volume ratio, and excellent biocompatibility.
{"title":"Preparation and in vitro characterization of electrospun scaffolds composed of chitosan, gelatin and 58S bioactive glass nanoparticles for skin tissue engineering","authors":"H. Nosrati, Mehdi Banitalebi-Dhkordi, M. Khodaei, E. Sharifi, Shiva Asadpour, K. Mansouri, Mostafa Soleimannejad","doi":"10.34172/jsums.2022.01","DOIUrl":"https://doi.org/10.34172/jsums.2022.01","url":null,"abstract":"Background and aims: The presence of an appropriate scaffold at the wound site could significantly improve the healing process. In this study, we aimed to prepare a biomimetic nanocomposite scaffold composed of chitosan, gelatin, and 58S bioglass nanoparticles for skin tissue engineering. Methods: The nanocomposite scaffolds composed of chitosan, gelatin, and 58S bioglass nanoparticles were fabricated through electrospinning process. Then the cell viability assay was performed in order to evaluate the biological properties of the membranes. The optimum concentration of bioglass nanoparticles was determined for further studies. In vitro characterization was also performed to evaluate physicochemical properties of the scaffolds. Results: The chitosan/gelatin scaffold containing 2% of 58S bioglass nanoparticles showed no cell toxicity, and the dermal fibroblasts were found capable of proliferation on the membrane. The in vitro results obtained from the scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and porosity tests demonstrated the appropriate properties of the membrane as a scaffold for skin regeneration. Conclusions: It was concluded that a chitosan-gelatin membrane containing 2% of 58S bioglass nanoparticles had the potential to function as a scaffold to accelerate wound healing due to its suitable properties, such as high porosity, high surface/volume ratio, and excellent biocompatibility.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130656166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Razavian, Kimia Hanjani, K. Hanjani, H. Mirmohammadi, Alireza Shabanian Boroujeni
Background and aims: AH26, Master-Dent, and Endoseal mineral trioxide aggregate (MTA) are three different types of sealers. The purpose of this study was to assess and compare THE apical seal of the root canal-treated teeth with the above-mentioned sealers in the presence and absence of moisture using the fluid filtration method. Methods: To this end, 54 freshly extracted single root canal human canines were selected for this study. The canals were prepared using rotary instruments, and then sodium hypochlorite was applied as an irrigation solution in this protocol. The specimens were randomly divided into three groups of 18. One group was obturated with the gutta-percha by the cold lateral compaction technique. Half of one of the aforementioned sealers belonged to the group of moistened teeth and the other half to the group of the dried teeth. Microleakage in all groups was assessed 3 months after the obturation of canals by the fluid filtration method. The data were analyzed using ANOVA and Tukey’s post hoc tests, and the level of significance was set at P<0.05. Results: The results showed that the minimum and maximum micro-leakage belonged to Masterdent dry (mean leakage = 1.7778 μL/ min/CmH20) and Endoseal-MTA dry (mean leakage = 3.5000 μL/min/CmH20), respectively. All three groups of sealers exhibited a significant difference in apical micro-leakage between dry and moist conditions (PMasterdent <0.001, PAH26=0.002, and PEndoseaL-MTA =0.007). Conclusion: The findings of this experimental study demonstrated that Masterdent provided the least apical micro-leakage under dry conditions while Endoseal-MTA had the highest micro-leakage under these conditions. There was a significant difference between dry and moist conditions in all groups.
{"title":"Evaluation of microleakage of three different endodontic sealers in the presence and absence of moisture","authors":"H. Razavian, Kimia Hanjani, K. Hanjani, H. Mirmohammadi, Alireza Shabanian Boroujeni","doi":"10.34172/jsums.2022.04","DOIUrl":"https://doi.org/10.34172/jsums.2022.04","url":null,"abstract":"Background and aims: AH26, Master-Dent, and Endoseal mineral trioxide aggregate (MTA) are three different types of sealers. The purpose of this study was to assess and compare THE apical seal of the root canal-treated teeth with the above-mentioned sealers in the presence and absence of moisture using the fluid filtration method. Methods: To this end, 54 freshly extracted single root canal human canines were selected for this study. The canals were prepared using rotary instruments, and then sodium hypochlorite was applied as an irrigation solution in this protocol. The specimens were randomly divided into three groups of 18. One group was obturated with the gutta-percha by the cold lateral compaction technique. Half of one of the aforementioned sealers belonged to the group of moistened teeth and the other half to the group of the dried teeth. Microleakage in all groups was assessed 3 months after the obturation of canals by the fluid filtration method. The data were analyzed using ANOVA and Tukey’s post hoc tests, and the level of significance was set at P<0.05. Results: The results showed that the minimum and maximum micro-leakage belonged to Masterdent dry (mean leakage = 1.7778 μL/ min/CmH20) and Endoseal-MTA dry (mean leakage = 3.5000 μL/min/CmH20), respectively. All three groups of sealers exhibited a significant difference in apical micro-leakage between dry and moist conditions (PMasterdent <0.001, PAH26=0.002, and PEndoseaL-MTA =0.007). Conclusion: The findings of this experimental study demonstrated that Masterdent provided the least apical micro-leakage under dry conditions while Endoseal-MTA had the highest micro-leakage under these conditions. There was a significant difference between dry and moist conditions in all groups.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133791452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamidreza Azizi Farsani, F. Behnaz, Zahra Azizi Farsani, S. Khorasanizadeh
Background and aims: Coronavirus disease 2019 (COVID-19) has posed many challenges for healthcare workers around the world. This study aims to present the most appropriate and evidence-based scientific advice for safe regional anesthesia practice during the COVID-19 pandemic. Methods: To perform regional anesthesia during respiratory disease outbreaks, several databases were investigated, including PubMed, Google Scholar, Up-to-date, and ScienceDirect. Searches were in English during a timeframe spanning from February 15, 2019, until February 15, 2021, and the applied keywords were "COVID-19 anesthesia", "surgery", and "operating room" Results: We have focused on definite areas such as workforce and resource planning, modification of clinical setting, preparation of equipment, supplies, and medications, selection of proper personal protective equipment (PPE), cardiorespiratory monitoring of the patient, and sedation and oxygen therapy. Other fields were assessing safe regional anesthesia techniques and monitoring during anesthesia, post-anesthesia care, and follow-ups. In these recommendations, keeping the patients safe while protecting healthcare providers from potential exposure to infection is of particular interest. Conclusion: The safety of healthcare workers and patients during the anesthesia management of suspected and positive COVID-19 cases is of utmost importance. Although there is limited evidence regarding performing regional anesthesia, these presented suggestions summarize the best accessible data and explain some doubts in this respect.
{"title":"Regional anesthesia during COVID-19 pandemic: A minireview and practical recommendations","authors":"Hamidreza Azizi Farsani, F. Behnaz, Zahra Azizi Farsani, S. Khorasanizadeh","doi":"10.34172/jsums.2022.08","DOIUrl":"https://doi.org/10.34172/jsums.2022.08","url":null,"abstract":"Background and aims: Coronavirus disease 2019 (COVID-19) has posed many challenges for healthcare workers around the world. This study aims to present the most appropriate and evidence-based scientific advice for safe regional anesthesia practice during the COVID-19 pandemic. Methods: To perform regional anesthesia during respiratory disease outbreaks, several databases were investigated, including PubMed, Google Scholar, Up-to-date, and ScienceDirect. Searches were in English during a timeframe spanning from February 15, 2019, until February 15, 2021, and the applied keywords were \"COVID-19 anesthesia\", \"surgery\", and \"operating room\" Results: We have focused on definite areas such as workforce and resource planning, modification of clinical setting, preparation of equipment, supplies, and medications, selection of proper personal protective equipment (PPE), cardiorespiratory monitoring of the patient, and sedation and oxygen therapy. Other fields were assessing safe regional anesthesia techniques and monitoring during anesthesia, post-anesthesia care, and follow-ups. In these recommendations, keeping the patients safe while protecting healthcare providers from potential exposure to infection is of particular interest. Conclusion: The safety of healthcare workers and patients during the anesthesia management of suspected and positive COVID-19 cases is of utmost importance. Although there is limited evidence regarding performing regional anesthesia, these presented suggestions summarize the best accessible data and explain some doubts in this respect.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116739339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Hejazi, S. Saberi, R. Arjmand, S. Soleimanifard
Background and aims: Regarding the increasing numbers of clinical antimonial-resistant Leishmaniasis, understanding the reasons for drug resistance is helpful. This study aimed to find the expression level of the genes related to resistance, P-glycoprotein A (PgpA), G-glutamylcysteine synthetase 1 (Gsh1), and aquaglyceroporin 1 (Aqp1) in antimonial-resistant clinical isolates. Methods: Samples were isolated from leishmaniasis ulcers of 10 non-healing patients and the species were identified by the nested-polymerase chain reaction (PCR) method. In vitro experiments were performed using the amastigote-macrophage model by J774 cell line, and in vivo studies were conducted by animal model, the Balb/c mice. Finally, the values of genes expression were determined by quantitative-reverse transcription (q-RT) real-time PCR method and then compared with non-resistant Leishmania major (MRHO/IR/75/ER). Results: Molecular identification showed that all isolated protozoa were L. major. The isolated samples from clinical resistant patients represented no increase in expression in the tested resistance genes (P>0.05). Finally, it was found that the lack of improvements in patients was not associated with the increased expression of resistance genes. Conclusion: In general, no inherent resistance was observed in the tested samples neither a correlation between the healing of lesions and the level of genes expression.
{"title":"The study of P-glycoprotein A, G-glutamylcysteine synthetase 1, and aquaglyceroporin 1 genes expression in non-healing zoonotic cutaneous leishmaniasis cases","authors":"S. Hejazi, S. Saberi, R. Arjmand, S. Soleimanifard","doi":"10.34172/jsums.2021.27","DOIUrl":"https://doi.org/10.34172/jsums.2021.27","url":null,"abstract":"Background and aims: Regarding the increasing numbers of clinical antimonial-resistant Leishmaniasis, understanding the reasons for drug resistance is helpful. This study aimed to find the expression level of the genes related to resistance, P-glycoprotein A (PgpA), G-glutamylcysteine synthetase 1 (Gsh1), and aquaglyceroporin 1 (Aqp1) in antimonial-resistant clinical isolates. Methods: Samples were isolated from leishmaniasis ulcers of 10 non-healing patients and the species were identified by the nested-polymerase chain reaction (PCR) method. In vitro experiments were performed using the amastigote-macrophage model by J774 cell line, and in vivo studies were conducted by animal model, the Balb/c mice. Finally, the values of genes expression were determined by quantitative-reverse transcription (q-RT) real-time PCR method and then compared with non-resistant Leishmania major (MRHO/IR/75/ER). Results: Molecular identification showed that all isolated protozoa were L. major. The isolated samples from clinical resistant patients represented no increase in expression in the tested resistance genes (P>0.05). Finally, it was found that the lack of improvements in patients was not associated with the increased expression of resistance genes. Conclusion: In general, no inherent resistance was observed in the tested samples neither a correlation between the healing of lesions and the level of genes expression.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133397040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Surgery is an important and life-saving health service that can treat many of the congenital anomalies. This study aimed to investigate the possible causes and outcomes of non-cardiac surgeries in newborns admitted to the neonatal invasive care unit (NICU) department of Be’sat Hospital in Hamadan during the period 2011 to 2017. Methods: This study included all neonates (482 newborns) who were admitted to the NICU department of Be’sat hospital during the period 2011-2017 due to non-cardiac surgery, and had hospital records. The required information was extracted from their hospital records and the surgical outcomes and complications were analyzed with respect to other variables such as the gender, type of delivery, gestational age, birth weight, and disease. Results: According to our study results, 80.5% of the newborns had the gastrointestinal disease which was the most common cause of surgery found in this study. Moreover, imperforated anus (20.8%) and esophageal atresia (17.1%) were among the most common disorders. Esophageal atresia (33.9%) was detected to be the most common disease among the newborns who died during the course of the study. The results from the study showed that the outcome of surgery had statistically significant relationship with gender (P=0.011), type of breastfeeding/feeding (P<0.001), gestational age (P<0.001), and birth weight (P<0.001). Conclusion: Fetal examinations during pregnancy and neonatal care immediately after birth were recommended for early diagnosis of esophageal atresia, diaphragmatic hernia, and imperforated anus. Since gender (male), breastfeeding, normal gestational age, and normal birth weight had a significantly positive effect on surgery outcome, higher quality care was also recommended for infants lacking these characteristics.
{"title":"Causes and results of non-cardiac surgeries in newborns admitted to the NICU","authors":"F. Eghbalian, Parastoo Najafi, A. Pirdehghan","doi":"10.34172/jsums.2021.29","DOIUrl":"https://doi.org/10.34172/jsums.2021.29","url":null,"abstract":"Background and aims: Surgery is an important and life-saving health service that can treat many of the congenital anomalies. This study aimed to investigate the possible causes and outcomes of non-cardiac surgeries in newborns admitted to the neonatal invasive care unit (NICU) department of Be’sat Hospital in Hamadan during the period 2011 to 2017. Methods: This study included all neonates (482 newborns) who were admitted to the NICU department of Be’sat hospital during the period 2011-2017 due to non-cardiac surgery, and had hospital records. The required information was extracted from their hospital records and the surgical outcomes and complications were analyzed with respect to other variables such as the gender, type of delivery, gestational age, birth weight, and disease. Results: According to our study results, 80.5% of the newborns had the gastrointestinal disease which was the most common cause of surgery found in this study. Moreover, imperforated anus (20.8%) and esophageal atresia (17.1%) were among the most common disorders. Esophageal atresia (33.9%) was detected to be the most common disease among the newborns who died during the course of the study. The results from the study showed that the outcome of surgery had statistically significant relationship with gender (P=0.011), type of breastfeeding/feeding (P<0.001), gestational age (P<0.001), and birth weight (P<0.001). Conclusion: Fetal examinations during pregnancy and neonatal care immediately after birth were recommended for early diagnosis of esophageal atresia, diaphragmatic hernia, and imperforated anus. Since gender (male), breastfeeding, normal gestational age, and normal birth weight had a significantly positive effect on surgery outcome, higher quality care was also recommended for infants lacking these characteristics.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116362548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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