首页 > 最新文献

Chronic Diseases and Translational Medicine最新文献

英文 中文
Guide for Authors 作者指南
Q1 Medicine Pub Date : 2024-07-16 DOI: 10.1002/cdt3.143
{"title":"Guide for Authors","authors":"","doi":"10.1002/cdt3.143","DOIUrl":"https://doi.org/10.1002/cdt3.143","url":null,"abstract":"","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"10 3","pages":"256-262"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum: Effects of long-term blood pressure variability on renal function in community population 更正:社区人口长期血压变化对肾功能的影响
Q1 Medicine Pub Date : 2024-07-11 DOI: 10.1002/cdt3.144

In the article titled, “Effects of long-term blood pressure variability on renal function in community population” published in pages 149–152, vol. 10 of Chronic Diseases and Translational Medicine,1 the order of the first author's name is incorrect. The first author's name should be Feng Zhao.

慢性病与转化医学》(Chronic Diseases and Translational Medicine)1 第 10 卷第 149-152 页发表的题为《社区人群长期血压变化对肾功能的影响》(Effects of long-term blood pressure variability on renal function in community population)的文章中,第一作者姓名顺序有误。第一作者的名字应为 Feng Zhao。
{"title":"Corrigendum: Effects of long-term blood pressure variability on renal function in community population","authors":"","doi":"10.1002/cdt3.144","DOIUrl":"https://doi.org/10.1002/cdt3.144","url":null,"abstract":"<p>In the article titled, “Effects of long-term blood pressure variability on renal function in community population” published in pages 149–152, vol. 10 of Chronic Diseases and Translational Medicine,<span><sup>1</sup></span> the order of the first author's name is incorrect. The first author's name should be Feng Zhao.</p>","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"10 4","pages":"351"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of eating out of home and type 2 diabetes mellitus in Chinese urban workers: A nationwide study 中国城市工人外出就餐与 2 型糖尿病的关系:一项全国性研究
Q1 Medicine Pub Date : 2024-06-13 DOI: 10.1002/cdt3.136
Fangyan Chen, Sitong Wan, Jinjuan Hao, Ke Sun, Annan Liu, Ling Zhu, Shuyan Wang, Jingjing He, Ping Zeng

Background

The prevalence of type 2 diabetes mellitus (T2DM) has been rapidly growing in Chinese populations in recent decades, and the shift in eating habits is a key contributing factor to this increase. Eating out of home (EOH) is one of the major shifts in eating habits during this period. However, the influence of EOH on the incidence of T2DM among Chinese urban workers is unknown.

Methods

The cross-sectional study involved an analysis of 13,904 urban workers recruited from 11 health examination centers in the major cities of China to explore the relationship between EOH and T2DM between 2013 September and 2016 March.

Results

Average weekly EOH frequency ≥10 times was positively associated with increased incidence of T2DM in the sampled population (OR: 1.31 [1.11–1.54], p < 0.01), most notably in participants ≤45 years old (OR: 1.41[1.11–1.80], p < 0.01]) and in males (OR:1.26 [1.06–1.51], p < 0.01). An EOH frequency of 5 times/week appears as a threshold for a significant increase in the odds of T2DM. Weekly EOH frequency ≥5 times was associated with increased odds of T2DM in a dose–response manner in the total population and almost all subgroups (poverall association < 0.05 and pnonlinearity ≤ 0.05).

Conclusion

This study showed that a frequency of EOH (≥5 times/week) was associated with a frequency-dependent increase in the odds of T2DM urban workers in China. More nutrition promotion is needed to improve the eating behavior of Chinese urban workers to reduce T2DM risk.

近几十年来,2 型糖尿病(T2DM)的发病率在中国人群中迅速增长,而饮食习惯的改变是导致这一增长的关键因素。外出就餐(EOH)是这一时期饮食习惯的主要转变之一。这项横断面研究分析了从中国主要城市的11个健康体检中心招募的13904名城镇职工,探讨2013年9月至2016年3月期间外出就餐与T2DM之间的关系。在抽样人群中,平均每周EOH频率≥10次与T2DM发病率的增加呈正相关(OR:1.31 [1.11-1.54],P <0.01),尤其是在年龄≤45岁的参与者中(OR:1.41 [1.11-1.80],P <0.01])和男性中(OR:1.26 [1.06-1.51],P <0.01)。每周 EOH 5 次似乎是 T2DM 发生率显著增加的临界值。在总人口和几乎所有亚组中,每周EOH频率≥5次与T2DM几率的增加呈剂量反应关系(总体相关性<0.05,非线性相关性≤0.05)。因此,需要加强营养宣传,改善中国城市工人的饮食行为,以降低 T2DM 风险。
{"title":"Association of eating out of home and type 2 diabetes mellitus in Chinese urban workers: A nationwide study","authors":"Fangyan Chen,&nbsp;Sitong Wan,&nbsp;Jinjuan Hao,&nbsp;Ke Sun,&nbsp;Annan Liu,&nbsp;Ling Zhu,&nbsp;Shuyan Wang,&nbsp;Jingjing He,&nbsp;Ping Zeng","doi":"10.1002/cdt3.136","DOIUrl":"10.1002/cdt3.136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The prevalence of type 2 diabetes mellitus (T2DM) has been rapidly growing in Chinese populations in recent decades, and the shift in eating habits is a key contributing factor to this increase. Eating out of home (EOH) is one of the major shifts in eating habits during this period. However, the influence of EOH on the incidence of T2DM among Chinese urban workers is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The cross-sectional study involved an analysis of 13,904 urban workers recruited from 11 health examination centers in the major cities of China to explore the relationship between EOH and T2DM between 2013 September and 2016 March.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Average weekly EOH frequency ≥10 times was positively associated with increased incidence of T2DM in the sampled population (OR: 1.31 [1.11–1.54], <i>p</i> &lt; 0.01), most notably in participants ≤45 years old (OR: 1.41[1.11–1.80], <i>p</i> &lt; 0.01]) and in males (OR:1.26 [1.06–1.51], <i>p</i> &lt; 0.01). An EOH frequency of 5 times/week appears as a threshold for a significant increase in the odds of T2DM. Weekly EOH frequency ≥5 times was associated with increased odds of T2DM in a dose–response manner in the total population and almost all subgroups (<i>p</i><sub>overall association</sub> &lt; 0.05 and <i>p</i><sub>nonlinearity</sub> ≤ 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study showed that a frequency of EOH (≥5 times/week) was associated with a frequency-dependent increase in the odds of T2DM urban workers in China. More nutrition promotion is needed to improve the eating behavior of Chinese urban workers to reduce T2DM risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"11 1","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guide for Authors 作者指南
Q1 Medicine Pub Date : 2024-06-11 DOI: 10.1002/cdt3.140
{"title":"Guide for Authors","authors":"","doi":"10.1002/cdt3.140","DOIUrl":"https://doi.org/10.1002/cdt3.140","url":null,"abstract":"","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"10 2","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement in oxygen dynamics after 3 months of home-based respiratory muscle rehabilitation in a patient with complex severe pulmonary hypertension: A case report 一名复杂性重度肺动脉高压患者经过 3 个月的家庭呼吸肌康复治疗后,氧动力得到改善:病例报告
Q1 Medicine Pub Date : 2024-06-09 DOI: 10.1002/cdt3.138
Xinxin Yan, Ya Song, Hongda Zhang, Tingting Guo, Xin Gao, Yan Wu, Lu Hua
<p>A 26-year-old woman with congenital heart disease, postatrial septal defect repair, postarterial catheter ligation, hypoxia-associated pulmonary hypertension, and reduced right heart function, which manifested as a severe decrease in activity tolerance, chest tightness and shortness of breath, and easy fatigue of breathing, was treated with oxygen, targeting medications such as anisentan, tadalafil, remodulin, and diuretic potassium supplementation to enhance cardiac function, and then her symptoms were slightly improved compared with the previous ones. She was guided with in-hospital respiratory training to the extent that the patient could tolerate it and then was discharged from the hospital to have a home-based respiratory rehabilitation for a period of 3 months. The training plan was as follows: (i) Respiratory muscle function test: the patient's resting maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) were assessed by the respiratory trainer equipment, and the respiratory muscle weakness/invulnerability was defined as a measured maximal pressure value less than 80 cmH<sub>2</sub>O according to the ERS guidelines.<span><sup>1</sup></span> (ii) Respiratory muscle training impedance progression: first month, 30% of the MIP and MEP of this test, 30 repetitions/day, 5–7 days/week for 1 month; second month, reassessment of respiratory muscle strength with impedance of 35% of the MIP and MEP of this test, 30 repetitions/day, 5–7 days/week for 1 month; and month 3, reassessment of respiratory muscle strength with impedance of MIP and 40% of MEP, 30 times/day, 5–7 days/week for 1 month. During the period of home respiratory rehabilitation, this patient did not experience any adverse hazardous events. (1) After 3 months of training, this patient's respiratory muscle strength improved, including a significant increase in MIP from 43 to 53 cmH<sub>2</sub>O and a slight increase in MEP from 53 to 57 cmH<sub>2</sub>O; peak inspiratory flow rate decreased from 2.77 to 3.50 L/s, and peak expiratory flow rate decreased from 3.01 to 2.57 L/s. (2) This patient's oxygen saturation improved with oxygen (91% vs. 94%) and her heart rate decreased significantly without oxygen (102 vs. 90 bpm) compared to before training (91% vs. 94%). Additionally, her heart rate was significantly lower (102 vs. 90 bpm), and oxygen saturation was significantly better (83% vs. 89%) without oxygen than it was 3 months prior. (3) Subjective symptoms improved, with the patient initially completing a training session with a Borg score of up to 12/20. After training, she completed the same session with a Borg score of 9–10/20. (4) Weakness improved. Before training, the patient experienced more than moderate shortness of breath with minimal activity and needed a wheelchair while in an oxygenated state. After the training, she could go up and down three staircases or walk on the flat ground for 3–4 min with much less perceived dyspnea.</p><p>Respiratory muscle
{"title":"Improvement in oxygen dynamics after 3 months of home-based respiratory muscle rehabilitation in a patient with complex severe pulmonary hypertension: A case report","authors":"Xinxin Yan,&nbsp;Ya Song,&nbsp;Hongda Zhang,&nbsp;Tingting Guo,&nbsp;Xin Gao,&nbsp;Yan Wu,&nbsp;Lu Hua","doi":"10.1002/cdt3.138","DOIUrl":"10.1002/cdt3.138","url":null,"abstract":"&lt;p&gt;A 26-year-old woman with congenital heart disease, postatrial septal defect repair, postarterial catheter ligation, hypoxia-associated pulmonary hypertension, and reduced right heart function, which manifested as a severe decrease in activity tolerance, chest tightness and shortness of breath, and easy fatigue of breathing, was treated with oxygen, targeting medications such as anisentan, tadalafil, remodulin, and diuretic potassium supplementation to enhance cardiac function, and then her symptoms were slightly improved compared with the previous ones. She was guided with in-hospital respiratory training to the extent that the patient could tolerate it and then was discharged from the hospital to have a home-based respiratory rehabilitation for a period of 3 months. The training plan was as follows: (i) Respiratory muscle function test: the patient's resting maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) were assessed by the respiratory trainer equipment, and the respiratory muscle weakness/invulnerability was defined as a measured maximal pressure value less than 80 cmH&lt;sub&gt;2&lt;/sub&gt;O according to the ERS guidelines.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; (ii) Respiratory muscle training impedance progression: first month, 30% of the MIP and MEP of this test, 30 repetitions/day, 5–7 days/week for 1 month; second month, reassessment of respiratory muscle strength with impedance of 35% of the MIP and MEP of this test, 30 repetitions/day, 5–7 days/week for 1 month; and month 3, reassessment of respiratory muscle strength with impedance of MIP and 40% of MEP, 30 times/day, 5–7 days/week for 1 month. During the period of home respiratory rehabilitation, this patient did not experience any adverse hazardous events. (1) After 3 months of training, this patient's respiratory muscle strength improved, including a significant increase in MIP from 43 to 53 cmH&lt;sub&gt;2&lt;/sub&gt;O and a slight increase in MEP from 53 to 57 cmH&lt;sub&gt;2&lt;/sub&gt;O; peak inspiratory flow rate decreased from 2.77 to 3.50 L/s, and peak expiratory flow rate decreased from 3.01 to 2.57 L/s. (2) This patient's oxygen saturation improved with oxygen (91% vs. 94%) and her heart rate decreased significantly without oxygen (102 vs. 90 bpm) compared to before training (91% vs. 94%). Additionally, her heart rate was significantly lower (102 vs. 90 bpm), and oxygen saturation was significantly better (83% vs. 89%) without oxygen than it was 3 months prior. (3) Subjective symptoms improved, with the patient initially completing a training session with a Borg score of up to 12/20. After training, she completed the same session with a Borg score of 9–10/20. (4) Weakness improved. Before training, the patient experienced more than moderate shortness of breath with minimal activity and needed a wheelchair while in an oxygenated state. After the training, she could go up and down three staircases or walk on the flat ground for 3–4 min with much less perceived dyspnea.&lt;/p&gt;&lt;p&gt;Respiratory muscle ","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"11 1","pages":"78-80"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141366864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathways to chronic disease detection and prediction: Mapping the potential of machine learning to the pathophysiological processes while navigating ethical challenges 慢性疾病检测和预测之路:将机器学习的潜力与病理生理过程相结合,同时应对伦理挑战
Q1 Medicine Pub Date : 2024-06-09 DOI: 10.1002/cdt3.137
Ebenezer Afrifa-Yamoah, Eric Adua, Emmanuel Peprah-Yamoah, Enoch O. Anto, Victor Opoku-Yamoah, Emmanuel Acheampong, Michael J. Macartney, Rashid Hashmi

Chronic diseases such as heart disease, cancer, and diabetes are leading drivers of mortality worldwide, underscoring the need for improved efforts around early detection and prediction. The pathophysiology and management of chronic diseases have benefitted from emerging fields in molecular biology like genomics, transcriptomics, proteomics, glycomics, and lipidomics. The complex biomarker and mechanistic data from these “omics” studies present analytical and interpretive challenges, especially for traditional statistical methods. Machine learning (ML) techniques offer considerable promise in unlocking new pathways for data-driven chronic disease risk assessment and prognosis. This review provides a comprehensive overview of state-of-the-art applications of ML algorithms for chronic disease detection and prediction across datasets, including medical imaging, genomics, wearables, and electronic health records. Specifically, we review and synthesize key studies leveraging major ML approaches ranging from traditional techniques such as logistic regression and random forests to modern deep learning neural network architectures. We consolidate existing literature to date around ML for chronic disease prediction to synthesize major trends and trajectories that may inform both future research and clinical translation efforts in this growing field. While highlighting the critical innovations and successes emerging in this space, we identify the key challenges and limitations that remain to be addressed. Finally, we discuss pathways forward toward scalable, equitable, and clinically implementable ML solutions for transforming chronic disease screening and prevention.

心脏病、癌症和糖尿病等慢性疾病是导致全球死亡的主要原因,这就突出表明需要加强早期检测和预测工作。慢性疾病的病理生理学和管理得益于分子生物学的新兴领域,如基因组学、转录组学、蛋白质组学、糖组学和脂质组学。来自这些 "omics "研究的复杂生物标志物和机理数据带来了分析和解释方面的挑战,尤其是对传统统计方法而言。机器学习(ML)技术在为数据驱动的慢性病风险评估和预后分析开辟新途径方面大有可为。本综述全面概述了机器学习算法在慢性病检测和预测方面的最新应用,包括医学成像、基因组学、可穿戴设备和电子健康记录等数据集。具体来说,我们回顾并总结了利用主要 ML 方法进行的关键研究,这些方法包括逻辑回归和随机森林等传统技术以及现代深度学习神经网络架构。我们整合了迄今为止围绕用于慢性疾病预测的 ML 的现有文献,归纳出主要趋势和轨迹,为这一不断发展的领域未来的研究和临床转化工作提供参考。在强调这一领域出现的关键创新和成功经验的同时,我们也指出了仍有待解决的关键挑战和局限性。最后,我们讨论了实现可扩展、公平和临床可实施的 ML 解决方案的途径,以改变慢性病筛查和预防。
{"title":"Pathways to chronic disease detection and prediction: Mapping the potential of machine learning to the pathophysiological processes while navigating ethical challenges","authors":"Ebenezer Afrifa-Yamoah,&nbsp;Eric Adua,&nbsp;Emmanuel Peprah-Yamoah,&nbsp;Enoch O. Anto,&nbsp;Victor Opoku-Yamoah,&nbsp;Emmanuel Acheampong,&nbsp;Michael J. Macartney,&nbsp;Rashid Hashmi","doi":"10.1002/cdt3.137","DOIUrl":"10.1002/cdt3.137","url":null,"abstract":"<p>Chronic diseases such as heart disease, cancer, and diabetes are leading drivers of mortality worldwide, underscoring the need for improved efforts around early detection and prediction. The pathophysiology and management of chronic diseases have benefitted from emerging fields in molecular biology like genomics, transcriptomics, proteomics, glycomics, and lipidomics. The complex biomarker and mechanistic data from these “omics” studies present analytical and interpretive challenges, especially for traditional statistical methods. Machine learning (ML) techniques offer considerable promise in unlocking new pathways for data-driven chronic disease risk assessment and prognosis. This review provides a comprehensive overview of state-of-the-art applications of ML algorithms for chronic disease detection and prediction across datasets, including medical imaging, genomics, wearables, and electronic health records. Specifically, we review and synthesize key studies leveraging major ML approaches ranging from traditional techniques such as logistic regression and random forests to modern deep learning neural network architectures. We consolidate existing literature to date around ML for chronic disease prediction to synthesize major trends and trajectories that may inform both future research and clinical translation efforts in this growing field. While highlighting the critical innovations and successes emerging in this space, we identify the key challenges and limitations that remain to be addressed. Finally, we discuss pathways forward toward scalable, equitable, and clinically implementable ML solutions for transforming chronic disease screening and prevention.</p>","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"11 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141367147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in the prevalence and incidence of chronic obstructive pulmonary disease among adults aged ≥50 years in the United States, 2000–2020 2000-2020 年美国年龄≥50 岁的成年人中慢性阻塞性肺病的流行率和发病率趋势
Q1 Medicine Pub Date : 2024-05-31 DOI: 10.1002/cdt3.135
Yaxian Meng, Qianqian Ji, Aijie Zhang, Yiqiang Zhan

Background

Understanding the trends of the prevalence and incidence rate of chronic obstructive pulmonary disease (COPD) is vital for improving the control and prevention of COPD. We aimed to examine the trends in the prevalence and incidence rate of COPD among adults aged 50 years or older in the United States during 2000–2020.

Methods

Utilizing data from the Health and Retirement Study, we analyzed COPD prevalence across survey waves and calculated COPD incidence rates between consecutive interview waves, stratified by gender and race. We employed joinpoint regression models to investigate trends in COPD prevalence and incidence.

Results

The individuals reporting COPD are more likely to be women and Caucasians. The age-adjusted prevalence of COPD among adults aged 50 years and over showed an increasing trend throughout the study period, spanning from 9.02% in 2000 to 9.88% in 2020 (average biennial percent change [ABPC] = 0.41, 95% confidence interval [CI]: 0.10, 0.71; p = 0.01). The age-adjusted incidence rate of COPD among adults aged 50 and over showed a decreasing trend throughout the study period 1031.1 per 100,000 person-years in 2000 to 700.5 per 100,000 person-years in 2020 (ABPC = −1.63, 95% CI: −2.88, −0.36; p = 0.02).

Conclusion

Our findings indicate a rising prevalence of COPD among older adults in the United States since 2000, while the incidence rate of COPD has shown a declining trend.

背景 了解慢性阻塞性肺病(COPD)的患病率和发病率趋势对于改善慢性阻塞性肺病的控制和预防至关重要。我们旨在研究 2000-2020 年间美国 50 岁及以上成年人慢性阻塞性肺病患病率和发病率的变化趋势。 方法 利用健康与退休研究(Health and Retirement Study)的数据,我们分析了不同调查波次之间的慢性阻塞性肺病患病率,并计算了连续访谈波次之间的慢性阻塞性肺病发病率,按性别和种族进行了分层。我们采用连接点回归模型来研究慢性阻塞性肺病患病率和发病率的趋势。 结果 报告慢性阻塞性肺病的人群中,女性和白种人的比例较高。在整个研究期间,50 岁及以上成年人中经年龄调整后的慢性阻塞性肺病患病率呈上升趋势,从 2000 年的 9.02% 上升至 2020 年的 9.88%(平均两年百分比变化 [ABPC] = 0.41,95% 置信区间 [CI]:0.10, 0.71; p = 0.01).在整个研究期间,50 岁及以上成人慢性阻塞性肺病的年龄调整后发病率呈下降趋势,从 2000 年的每 10 万人年 1031.1 例降至 2020 年的每 10 万人年 700.5 例(ABPC = -1.63, 95% CI: -2.88, -0.36; p = 0.02)。 结论 我们的研究结果表明,自 2000 年以来,美国老年人的慢性阻塞性肺病患病率不断上升,而慢性阻塞性肺病的发病率却呈下降趋势。
{"title":"Trends in the prevalence and incidence of chronic obstructive pulmonary disease among adults aged ≥50 years in the United States, 2000–2020","authors":"Yaxian Meng,&nbsp;Qianqian Ji,&nbsp;Aijie Zhang,&nbsp;Yiqiang Zhan","doi":"10.1002/cdt3.135","DOIUrl":"https://doi.org/10.1002/cdt3.135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Understanding the trends of the prevalence and incidence rate of chronic obstructive pulmonary disease (COPD) is vital for improving the control and prevention of COPD. We aimed to examine the trends in the prevalence and incidence rate of COPD among adults aged 50 years or older in the United States during 2000–2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilizing data from the Health and Retirement Study, we analyzed COPD prevalence across survey waves and calculated COPD incidence rates between consecutive interview waves, stratified by gender and race. We employed joinpoint regression models to investigate trends in COPD prevalence and incidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The individuals reporting COPD are more likely to be women and Caucasians. The age-adjusted prevalence of COPD among adults aged 50 years and over showed an increasing trend throughout the study period, spanning from 9.02% in 2000 to 9.88% in 2020 (average biennial percent change [ABPC] = 0.41, 95% confidence interval [CI]: 0.10, 0.71; <i>p</i> = 0.01). The age-adjusted incidence rate of COPD among adults aged 50 and over showed a decreasing trend throughout the study period 1031.1 per 100,000 person-years in 2000 to 700.5 per 100,000 person-years in 2020 (ABPC = −1.63, 95% CI: −2.88, −0.36; <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings indicate a rising prevalence of COPD among older adults in the United States since 2000, while the incidence rate of COPD has shown a declining trend.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"10 4","pages":"302-311"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Bayesian network for estimating hypertension risk due to occupational aluminum exposure 贝叶斯网络估算职业性铝暴露导致的高血压风险
Q1 Medicine Pub Date : 2024-05-30 DOI: 10.1002/cdt3.134
Le Zhao, Jinzhu Yin, Jiaping Huan, Xiao Han, Dan Zhao, Jing Song, Linping Wang, Huifang Zhang, Baolong Pan, Qiao Niu, Xiaoting Lu

Background

The correlation between metals and hypertension, such as sodium, zinc, potassium, and magnesium, has been confirmed, while the relationship between aluminum and hypertension is not very clear. This study aimed to evaluate the correlation between plasma aluminum and hypertension in electrolytic aluminum workers by the Bayesian networks (BN).

Methods

In 2019, 476 male workers in an aluminum factory were investigated. The plasma aluminum concentration of workers was measured by inductively coupled plasma mass spectrometry. The influencing factors on the prevalence of hypertension were analyzed by the BN.

Results

The prevalence of hypertension was 23.9% in 476 male workers. The risk of hypertension from plasma aluminum in the Q2, Q3, and Q4 groups was 5.20 (1.90–14.25), 6.92 (2.51–19.08), and 7.33 (2.69–20.01), respectively, compared with that in the Q1 group. The risk of hypertension from the duration of exposure to aluminum of >10 years was 2.23 (1.09–4.57), compared without aluminum exposure. Area under the curve was 0.80 of plasma aluminum and the duration of exposure to aluminum was based on covariates, indicating that aluminum exposure had important predictive value in the prevalence of hypertension in the occupational population. The results of the study using the BN model showed that if the plasma aluminum of all participants was higher than Q4 (≥47.86 µg/L) and the participants were drinking, smoking, diabetes, central obesity, dyslipidemia, and aged >50 years, the proportion of hypertension was 71.2%.

Conclusions

The prevalence of hypertension increased significantly with the increase of plasma aluminum level.

背景 金属(如钠、锌、钾和镁)与高血压之间的相关性已得到证实,而铝与高血压之间的关系还不是很清楚。本研究旨在通过贝叶斯网络(BN)评估电解铝工人血浆铝与高血压之间的相关性。 方法 在2019年,对一家铝厂的476名男性工人进行了调查。采用电感耦合等离子体质谱法测量了工人的血浆铝浓度。用 BN 分析了高血压患病率的影响因素。 结果 476 名男工的高血压患病率为 23.9%。与 Q1 组相比,Q2、Q3 和 Q4 组的高血压风险分别为 5.20(1.90-14.25)、6.92(2.51-19.08)和 7.33(2.69-20.01)。与未接触铝的人群相比,接触铝10年的人群患高血压的风险为2.23(1.09-4.57)。血浆铝的曲线下面积为 0.80,而铝暴露持续时间是基于协变量的,这表明铝暴露对职业人群高血压患病率具有重要的预测价值。使用 BN 模型的研究结果显示,如果所有参与者的血浆铝高于 Q4(≥47.86 µg/L),且参与者有饮酒、吸烟、糖尿病、中心性肥胖、血脂异常、年龄>50 岁,则高血压患病比例为 71.2%。 结论 随着血浆铝水平的升高,高血压患病率显著增加。
{"title":"A Bayesian network for estimating hypertension risk due to occupational aluminum exposure","authors":"Le Zhao,&nbsp;Jinzhu Yin,&nbsp;Jiaping Huan,&nbsp;Xiao Han,&nbsp;Dan Zhao,&nbsp;Jing Song,&nbsp;Linping Wang,&nbsp;Huifang Zhang,&nbsp;Baolong Pan,&nbsp;Qiao Niu,&nbsp;Xiaoting Lu","doi":"10.1002/cdt3.134","DOIUrl":"https://doi.org/10.1002/cdt3.134","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The correlation between metals and hypertension, such as sodium, zinc, potassium, and magnesium, has been confirmed, while the relationship between aluminum and hypertension is not very clear. This study aimed to evaluate the correlation between plasma aluminum and hypertension in electrolytic aluminum workers by the Bayesian networks (BN).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In 2019, 476 male workers in an aluminum factory were investigated. The plasma aluminum concentration of workers was measured by inductively coupled plasma mass spectrometry. The influencing factors on the prevalence of hypertension were analyzed by the BN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of hypertension was 23.9% in 476 male workers. The risk of hypertension from plasma aluminum in the Q2, Q3, and Q4 groups was 5.20 (1.90–14.25), 6.92 (2.51–19.08), and 7.33 (2.69–20.01), respectively, compared with that in the Q1 group. The risk of hypertension from the duration of exposure to aluminum of &gt;10 years was 2.23 (1.09–4.57), compared without aluminum exposure. Area under the curve was 0.80 of plasma aluminum and the duration of exposure to aluminum was based on covariates, indicating that aluminum exposure had important predictive value in the prevalence of hypertension in the occupational population. The results of the study using the BN model showed that if the plasma aluminum of all participants was higher than Q4 (≥47.86 µg/L) and the participants were drinking, smoking, diabetes, central obesity, dyslipidemia, and aged &gt;50 years, the proportion of hypertension was 71.2%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prevalence of hypertension increased significantly with the increase of plasma aluminum level.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"10 2","pages":"130-139"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertension and human health: Evidence and prospects 高血压与人类健康:证据与前景
Q1 Medicine Pub Date : 2024-05-30 DOI: 10.1002/cdt3.129
Fangchao Liu, Xiangfeng Lu

High blood pressure is a major public health issue and a leading risk factor for death worldwide, with the number of attributable deaths increased from 6.8 million in 1990 to 10.8 million in 2019.1, 2 According to the World Health Organization, the age-standardized prevalence of hypertension was estimated to be 33%, affecting approximately 1.3 billion adults aged 30–79 years in 2019 worldwide, doubling from 1990.3 In addition to the heavy disease burden, the economic burden associated with hypertension is also substantial, accounting for approximately 10% of the global healthcare expenditure.4 Furthermore, despite improvements in diagnostic and treatment capacities, the status of hypertension care remains suboptimal, especially in low- and middle-income countries. For instance, in China, in 2019, the awareness, treatment, and control rates of hypertension were 38.3%, 34.6%, and 12.0%, respectively.5 Accumulating evidence calls for more comprehensive and effective prevention and management of hypertension.

Multiple risk factors for hypertension have been well established, including genetic background, high sodium intake, smoking, physical inactivity, obesity, and alcohol intake.6, 7 Other potential risk factors (e.g., air pollution, psychological disorders, sleep habits, and noise exposure) have received increasing attention in recent years.4 To enhance the efficacy of prevention, identifying the potential risk factors for hypertension within specific populations and developing advanced tools to improve adherence to interventions remain imperative. In addition to lifestyle modifications, pharmacological treatment is essential for managing hypertension. Moreover, hypertension may cause other diseases such as cardiovascular disease, chronic kidney disease, and dementia.8, 9 Additionally, hypertension during pregnancy is associated with adverse consequences for offspring, including preterm birth, vascular dysfunction, and cognitive impairment.10, 11 Therefore, it is important to systematically understand the current research status of hypertension and related diseases.

In this special issue, authors from the United States, United Kingdom, China, India, and Pakistan report the latest research findings on hypertension and related diseases. The issue comprises eight publications, including four original articles, two brief reports, one study protocol, and one correspondence. In summary, the aforementioned studies employed different epidemiological designs to assess the risk factors for hypertension, identify molecular biomarkers for pre-eclampsia (PE), depict the adverse impact of blood pressure on various outcomes, and provide potential evidence for hypertension management and treatment.

Zhang et al.12 offered valuable

目前的证据表明,预防高血压的发展和控制好患者的高血压状态对认知有益,长期的血压变化与未来的肾脏损害有关,这两方面都强调了高血压对心血管健康以外的深远影响、19 在过去的二十年中,移动医疗发展迅速,并成为通过促进高血压患者坚持生活方式干预来提高控制率的潜在策略20。共有 154 人将被随机分配接受为期 8 周的干预,每两周进行一次跟踪评估。一般来说,移动医疗可以弥补常规医疗的不足,包括医疗队伍、生活方式调整指导和坚持治疗支持方面的不足。21 此外,由于人口增长和老龄化,高血压患者人数呈持续上升趋势,加剧了高血压所造成的疾病负担。22 这些见解通过整合遗传信息、分子生物标记物和新药应用,以及利用现代技术,从多方面概述了高血压预防、管理和治疗的广泛领域。此外,这些研究还强调了高血压对心血管系统之外的不良影响,并提倡高血压的终身管理。F. Liu参与了文献综述和文章起草。卢向峰教授是《慢性病与转化医学》编委会成员,未参与本文的同行评议和决策过程。
{"title":"Hypertension and human health: Evidence and prospects","authors":"Fangchao Liu,&nbsp;Xiangfeng Lu","doi":"10.1002/cdt3.129","DOIUrl":"https://doi.org/10.1002/cdt3.129","url":null,"abstract":"<p>High blood pressure is a major public health issue and a leading risk factor for death worldwide, with the number of attributable deaths increased from 6.8 million in 1990 to 10.8 million in 2019.<span><sup>1, 2</sup></span> According to the World Health Organization, the age-standardized prevalence of hypertension was estimated to be 33%, affecting approximately 1.3 billion adults aged 30–79 years in 2019 worldwide, doubling from 1990.<span><sup>3</sup></span> In addition to the heavy disease burden, the economic burden associated with hypertension is also substantial, accounting for approximately 10% of the global healthcare expenditure.<span><sup>4</sup></span> Furthermore, despite improvements in diagnostic and treatment capacities, the status of hypertension care remains suboptimal, especially in low- and middle-income countries. For instance, in China, in 2019, the awareness, treatment, and control rates of hypertension were 38.3%, 34.6%, and 12.0%, respectively.<span><sup>5</sup></span> Accumulating evidence calls for more comprehensive and effective prevention and management of hypertension.</p><p>Multiple risk factors for hypertension have been well established, including genetic background, high sodium intake, smoking, physical inactivity, obesity, and alcohol intake.<span><sup>6, 7</sup></span> Other potential risk factors (e.g., air pollution, psychological disorders, sleep habits, and noise exposure) have received increasing attention in recent years.<span><sup>4</sup></span> To enhance the efficacy of prevention, identifying the potential risk factors for hypertension within specific populations and developing advanced tools to improve adherence to interventions remain imperative. In addition to lifestyle modifications, pharmacological treatment is essential for managing hypertension. Moreover, hypertension may cause other diseases such as cardiovascular disease, chronic kidney disease, and dementia.<span><sup>8, 9</sup></span> Additionally, hypertension during pregnancy is associated with adverse consequences for offspring, including preterm birth, vascular dysfunction, and cognitive impairment.<span><sup>10, 11</sup></span> Therefore, it is important to systematically understand the current research status of hypertension and related diseases.</p><p>In this special issue, authors from the United States, United Kingdom, China, India, and Pakistan report the latest research findings on hypertension and related diseases. The issue comprises eight publications, including four original articles, two brief reports, one study protocol, and one correspondence. In summary, the aforementioned studies employed different epidemiological designs to assess the risk factors for hypertension, identify molecular biomarkers for pre-eclampsia (PE), depict the adverse impact of blood pressure on various outcomes, and provide potential evidence for hypertension management and treatment.</p><p>Zhang et al.<span><sup>12</sup></span> offered valuable ","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"10 2","pages":"89-91"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical activity, long-term fine particulate matter exposure and type 2 diabetes incidence: A prospective cohort study 体育锻炼、长期细颗粒物暴露和 2 型糖尿病发病率:前瞻性队列研究
Q1 Medicine Pub Date : 2024-05-30 DOI: 10.1002/cdt3.128
Qian Li, Fangchao Liu, Keyong Huang, Fengchao Liang, Chong Shen, Jian Liao, Jianxin Li, Chenxi Yuan, Xueli Yang, Jie Cao, Shufeng Chen, Dongsheng Hu, Jianfeng Huang, Yang Liu, Xiangfeng Lu, Dongfeng Gu

Background

Despite the adverse effects of ambient fine particulate matter (PM2.5) on type 2 diabetes and the beneficial role of physical activity (PA), the influence of PM2.5 on the relationship between PA and type 2 diabetes remains unclear.

Methods

In this prospective study with 71,689 participants, PA was assessed by a questionnaire and was categorized into quartiles for volume and three groups for intensity. Long-term PM2.5 exposure was calculated using 1-km resolution satellite-based PM2.5 estimates. PM2.5 exposure and PA's effect on type 2 diabetes were assessed by cohort-stratified Cox proportional hazards models, individually and in combination.

Results

In 488,166 person-years of follow-up, 5487 incident type 2 diabetes cases were observed. The association between PA and type 2 diabetes was modified by PM2.5. Compared with the lowest quartile of PA volume, the highest quartile was associated with reduced type 2 diabetes risk in low PM2.5 stratification (≤65.02 µg/m3) other than in high PM2.5 stratification (>65.02 µg/m3), with the hazard ratio (HR) of 0.75 (95% confidence interval [CI]: 0.66–0.85) and 1.10 (95% CI: 0.99–1.22), respectively. Similar results were observed for PA intensity. High PM2.5 exposure combined with the highest PA levels increased the risk of type 2 diabetes the most (HR = 1.79, 95% CI: 1.59–2.01 for PA volume; HR = 1.82, 95% CI: 1.64–2.02 for PA intensity).

Conclusion

PA could reduce type 2 diabetes risk in low-pollution areas, but high PM2.5 exposure may weaken or even reverse the protective effects of PA. Safety and health benefits of PA should be thoroughly assessed for long-term polluted residents.

背景 尽管环境中的细颗粒物(PM2.5)对 2 型糖尿病有不利影响,而体育锻炼(PA)对 2 型糖尿病有益,但 PM2.5 对体育锻炼与 2 型糖尿病之间关系的影响仍不清楚。 方法 在这项有 71,689 名参与者参加的前瞻性研究中,通过问卷对运动量进行了评估,并将运动量分为四等分,将运动强度分为三组。长期PM2.5暴露量是通过1公里分辨率的卫星PM2.5估算值计算得出的。PM2.5暴露量和PA对2型糖尿病的影响通过队列分层考克斯比例危险模型进行单独或组合评估。 结果 在 488,166 人年的随访中,共观察到 5487 例 2 型糖尿病病例。PA与2型糖尿病之间的关系因PM2.5而改变。与PM2.5最低四分位数相比,在PM2.5低分层(≤65.02 µg/m3)中,PM2.5最高四分位数与2型糖尿病风险的相关性低于PM2.5高分层(65.02 µg/m3),其危险比(HR)分别为0.75(95%置信区间[CI]:0.66-0.85)和1.10(95%置信区间:0.99-1.22)。PA强度也有类似的结果。PM2.5暴露量高与PA水平最高相结合,2型糖尿病风险增加最多(PA量的HR = 1.79,95% CI:1.59-2.01;PA强度的HR = 1.82,95% CI:1.64-2.02)。 结论 在低污染地区,体育锻炼可降低 2 型糖尿病风险,但 PM2.5 暴露过高可能会削弱甚至逆转体育锻炼的保护作用。应全面评估 PA 对长期受污染居民的安全和健康益处。
{"title":"Physical activity, long-term fine particulate matter exposure and type 2 diabetes incidence: A prospective cohort study","authors":"Qian Li,&nbsp;Fangchao Liu,&nbsp;Keyong Huang,&nbsp;Fengchao Liang,&nbsp;Chong Shen,&nbsp;Jian Liao,&nbsp;Jianxin Li,&nbsp;Chenxi Yuan,&nbsp;Xueli Yang,&nbsp;Jie Cao,&nbsp;Shufeng Chen,&nbsp;Dongsheng Hu,&nbsp;Jianfeng Huang,&nbsp;Yang Liu,&nbsp;Xiangfeng Lu,&nbsp;Dongfeng Gu","doi":"10.1002/cdt3.128","DOIUrl":"https://doi.org/10.1002/cdt3.128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite the adverse effects of ambient fine particulate matter (PM<sub>2.5</sub>) on type 2 diabetes and the beneficial role of physical activity (PA), the influence of PM<sub>2.5</sub> on the relationship between PA and type 2 diabetes remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective study with 71,689 participants, PA was assessed by a questionnaire and was categorized into quartiles for volume and three groups for intensity. Long-term PM<sub>2.5</sub> exposure was calculated using 1-km resolution satellite-based PM<sub>2.5</sub> estimates. PM<sub>2.5</sub> exposure and PA's effect on type 2 diabetes were assessed by cohort-stratified Cox proportional hazards models, individually and in combination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 488,166 person-years of follow-up, 5487 incident type 2 diabetes cases were observed. The association between PA and type 2 diabetes was modified by PM<sub>2.5</sub>. Compared with the lowest quartile of PA volume, the highest quartile was associated with reduced type 2 diabetes risk in low PM<sub>2.5</sub> stratification (≤65.02 µg/m<sup>3</sup>) other than in high PM<sub>2.5</sub> stratification (&gt;65.02 µg/m<sup>3</sup>), with the hazard ratio (HR) of 0.75 (95% confidence interval [CI]: 0.66–0.85) and 1.10 (95% CI: 0.99–1.22), respectively. Similar results were observed for PA intensity. High PM<sub>2.5</sub> exposure combined with the highest PA levels increased the risk of type 2 diabetes the most (HR = 1.79, 95% CI: 1.59–2.01 for PA volume; HR = 1.82, 95% CI: 1.64–2.02 for PA intensity).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PA could reduce type 2 diabetes risk in low-pollution areas, but high PM<sub>2.5</sub> exposure may weaken or even reverse the protective effects of PA. Safety and health benefits of PA should be thoroughly assessed for long-term polluted residents.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"10 3","pages":"205-215"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cdt3.128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Chronic Diseases and Translational Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1