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Protective Effect of Combination Black Seed Oil (Nigella sativa) and Honey on the Duodenum of Rats Exposed to Cisplatin 黑籽油和蜂蜜对顺铂暴露大鼠十二指肠的保护作用
Pub Date : 2023-03-17 DOI: 10.24853/mmj.4.1.8-14
Khusnul Wasilah, M. I. Ilmiawan, Mitra Handini
Background: Cisplatin (CP) is an anticancer agent with various side effects, including duodenal mucosal damage. It is well known that black seed oil (BSO) and honey (H) are rich in antioxidants and have a mucosal protective effect. Purposes: To determine the protective effect of the BSO and H combination on the histopathology of duodenal rats given CP exposure. Methods: Randomized post-test-only control group design was used in this study. A total of 30 rats were divided into ten groups, namely the control group (K), treatment groups (P1-P8), and cisplatin group (C). The treatment groups were given BSO and H orally for 21 days, and CP was given intraperitoneally on day 18 to the treatment and cisplatin groups. On day 22, the duodenal tissue was taken for preparation and histopathological assessment. Data analysis using IBM SPSS v.24 and Compusyn program. Result: There were significant differences in the duodenal mucosa damage scores of the P1-P8 group compared to the C group (p<0.05). The combination index of P7 exerted a synergism effect (CI < 1). Conclusion: The combination of BSO and H exerted a protective effect on the histopathological of rats’ duodenal tissue induced with CP, and the combination of BSO 2 mL/KgBW and H 3.7 mL/KgBW exerted a synergism effect.
背景:顺铂(CP)是一种具有多种副作用的抗癌药物,包括十二指肠黏膜损伤。众所周知,黑籽油(BSO)和蜂蜜(H)富含抗氧化剂,具有保护粘膜的作用。目的:探讨BSO和H组合对CP暴露大鼠十二指肠组织病理学的保护作用。方法:采用随机后验对照组设计。将30只大鼠分为10组,分别为对照组(K)、治疗组(p1 ~ p8)、顺铂组(C)。治疗组给予BSO、H口服21 d,治疗组和顺铂组于第18天腹腔给予CP。第22天取十二指肠组织制备并进行组织病理学评估。数据分析使用IBM SPSS v.24和Compusyn程序。结果:p1 ~ p8组十二指肠黏膜损伤评分与C组比较,差异有统计学意义(p<0.05)。P7联合指数具有协同作用(CI < 1)。结论:BSO与H联合对CP诱导的大鼠十二指肠组织病理学有保护作用,BSO 2 mL/KgBW与h3.7 mL/KgBW联合具有协同作用。
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引用次数: 0
Risk Factors of Injury Severity Level in Foreign Tourists Visiting Bali 巴厘岛外国游客损伤严重程度的危险因素分析
Pub Date : 2023-03-17 DOI: 10.24853/mmj.4.1.25-31
Putu Indah Budiapsari, Wayan Widhidewi, Ketut Hari Muliawan, Ady Wirawan
Background: Injuries are the highest cause of death for international tourists, especially injuries caused by traffic accidents. The severity level of injury is the most cause of death. It is necessary to analyze the risk factor of injury severity among international travelers visiting Bali. Purpose: This study aimed to investigate the risk factors for injury severity in foreign tourists visiting Bali. Methods: This cross-sectional analytic study used foreign tourists visiting an international hospital in Bali as the research sample. This research was conducted by analyzing medical records using Injury Severity Score. Data on respondent characteristics, including age, gender, and injury characteristics, including location, type of injury, degree of severity, and injury mechanism, were analyzed using cross-tabulation. Results: The most types of trauma were closed fractures, 49 people (45.4%), and the most common causes were traffic accidents, namely 39 (36.1%) people. Based on the injury region, the lower Extremity is 36 (33.3%) mostly. Conclusion: Age, gender, type of injury, and mechanism of the accident was significant factor influencing the severity of injury among travelers visiting Bali (p<0.05).
背景:伤害是国际游客死亡的最大原因,尤其是交通事故造成的伤害。伤害的严重程度是导致死亡的最主要原因。分析巴厘岛国际游客损伤严重程度的危险因素是有必要的。目的:探讨巴厘岛外国游客损伤严重程度的危险因素。方法:以在巴厘岛某国际医院就诊的外国游客为研究样本进行横断面分析研究。本研究采用损伤严重程度评分法对医疗记录进行分析。调查对象的年龄、性别和损伤特征(包括部位、损伤类型、严重程度和损伤机制)数据采用交叉表法进行分析。结果:致伤类型以闭合性骨折最多,49人(45.4%);致伤原因以交通事故最多,39人(36.1%)。按损伤部位分,下肢占36例(33.3%)。结论:年龄、性别、伤害类型和事故发生机制是影响巴厘岛游客伤害严重程度的重要因素(p<0.05)。
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引用次数: 0
Management of Henoch-Schonlein Purpura with Gastrointestinal Manifestations in Children 儿童过敏性紫癜伴胃肠道症状的治疗
Pub Date : 2023-03-17 DOI: 10.24853/mmj.4.1.15-24
Rizki Luthfia Wardhani, Siti Ariffatus Saroh
Henoch-Schonlein Purpura (HSP) is systemic vasculitis in children, hallmark by inflammatory infiltration of polymonuclear leukocytes in small blood vessels, followed by IgA1 immune deposits. HSP prevalence is approximately 3-27 cases per 100,000 children. The inflammatory process in HSP causes an ischemia and hemorrhagic process characterized by non-thrombocytopenia purpura, arthralgia, gastrointestinal problems, and kidney impairment. This process is called leukocytoclastic vasculitis. A 10-year-old boy came to ER of Dr. Sayidiman Magetan Hospital presenting with diffuse abdominal pain and purpura skin lesions in body. The complaint started with a red rash on both legs, then progressively extended to both hands, thighs, and buttocks, and continued with severe abdominal discomfort, nausea, dizziness, fever, and the patient also experienced a brownish-black stool. The patient was diagnosed with Henoch-Schonlein purpura with gastrointestinal manifestations based on medical examination. The patient stayed for six days at the hospital, and the condition improved.
过敏性紫癜(HSP)是一种儿童全身性血管炎,以小血管中多核白细胞的炎症浸润为特征,随后出现IgA1免疫沉积。热休克流行率约为每10万名儿童3-27例。热休克的炎症过程引起缺血和出血过程,其特征为非血小板减少性紫癜、关节痛、胃肠道问题和肾脏损害。这个过程被称为白细胞破裂性血管炎。一个10岁的男孩来到Dr. Sayidiman Magetan医院急诊室,表现为弥漫性腹痛和身体紫癜性皮肤病变。主诉开始时双腿出现红色皮疹,随后逐渐扩展到双手、大腿和臀部,持续出现严重腹部不适、恶心、头晕、发烧,患者还出现棕黑色大便。经医学检查,诊断为过敏性紫癜,伴有胃肠道症状。病人在医院住了六天,病情有所好转。
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引用次数: 0
Clinical Characteristics of Acute Kidney Injury in Covid-19 Patients Covid-19患者急性肾损伤的临床特点
Pub Date : 2023-03-17 DOI: 10.24853/mmj.4.1.1-7
Nada Nisrina, Resna Murti Wibowo
Background: Coronavirus Disease 2019 (COVID-19) is one of the infectious diseases that exist in Indonesia. Not only infects the lungs, but this virus can also infect other organs such as the kidneys. In addition, the process of viral infection causes cell hypermetabolism, which can increase the workload of the kidneys in excreting metabolic waste. In the end, the damage caused by the virus can cause Acute Kidney Injury (AKI). It is necessary to know the prevalence and characteristics of this event. Purposes: This study aims to provide an overview of AKI's prevalence and clinical features in COVID-19 patients. Methods: This was a descriptive study that used patient medical records for the period April-September 2021. The univariate analysis data showed a characteristic frequency distribution of age, gender, comorbidity, hospitalization duration, and urea creatinine rate. Results: The incoming samples based on the inclusion and exclusion criteria were 44 samples. In COVID-19 patients, complications of AKI were found in adults, as much as 68.2% of both men and women had a percentage of 50%, the most common comorbid was hypertension 30.8% with a hospitalization duration of 1-10 days 43.2% and an average increase in urea 79.68 mg/dL and creatinine average 2,859 mg/dL. Conclusion: Based on patient characteristics, the results showed that more COVID-19 patients with acute kidney injury complications occurred in adult patients, with no difference in prevalence between males and females, with comorbid hypertension and length of hospitalization less than ten days.
背景:2019冠状病毒病(COVID-19)是印度尼西亚存在的传染病之一。这种病毒不仅会感染肺部,还会感染肾脏等其他器官。此外,病毒感染的过程会引起细胞的高代谢,从而增加肾脏排泄代谢废物的工作量。最后,病毒造成的损害可导致急性肾损伤(AKI)。有必要了解这一事件的流行程度和特点。目的:本研究旨在概述COVID-19患者AKI的患病率和临床特征。方法:这是一项描述性研究,使用了2021年4月至9月期间的患者医疗记录。单因素分析数据显示年龄、性别、合并症、住院时间和尿素肌酐率具有特征性的频率分布。结果:按纳入、排除标准入样44份。在COVID-19患者中,成人出现AKI并发症,男女比例均高达68.2%,最常见的合并症为高血压30.8%,住院时间为1-10天43.2%,尿素平均升高79.68 mg/dL,肌酐平均升高2,859 mg/dL。结论:结合患者特征,结果显示成人患者中合并急性肾损伤并发症的患者较多,男女患病率无差异,合并高血压,住院时间小于10天。
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引用次数: 1
Relationship between Age and Sex with Histopathological Differentiation of Colorectal Adenocarcinoma 年龄、性别与结直肠腺癌组织病理分化的关系
Pub Date : 2022-12-14 DOI: 10.24853/mmj.3.2.67-73
S. Sugiarto, Alifia Nurfitriana, Mieke Marindawati
Background: Colorectal cancer is one of the most common cancers causing morbidity in both women and men. There is a tendency for women over 65 to show higher mortality and lower 5-year survival rate from colorectal cancer than their male counterparts of the same age. Purposes: To find out the relationship between age and sex with the degree of differentiation of colorectal adenocarcinoma in the Anatomical Pathology Laboratory of General Hospital of Cengkareng in 2015 – 2019. Methods: This study used a analytic study with a retrospective approach, with secondary data from the medical records of anatomic pathology examination results in colorectal adenocarcinoma patients in General Hospital of Cengkareng in 2019. Result: Based on the result of the chi-square statistical test, the relationship between age and the degree of differentiation of colorectal adenocarcinomas was found to be p-value 0.476 (a>0.05). Whereas the relationship between sex with the degree of colorectal adenocarcinoma was found to be p-value 0.049 (a<0.05). Conclusion: There is no relationship between age and the degree of differentiation of colorectal adenocarcinomas, but gender have correlation.
背景:结直肠癌是男性和女性中最常见的癌症之一。与同龄男性相比,65岁以上的女性结直肠癌的死亡率更高,5年生存率更低。目的:了解2015 - 2019年成都市综合医院解剖病理实验室结直肠癌分化程度与年龄、性别的关系。方法:本研究采用回顾性分析研究方法,二次资料来源于2019年耿连市总医院结肠腺癌患者解剖病理检查结果病历。结果:根据卡方统计检验结果,年龄与结直肠癌分化程度的关系为p值0.476 (a>0.05)。而性别与结直肠腺癌程度的关系p值为0.049 (a<0.05)。结论:年龄与结肠腺癌的分化程度无关,而性别与之相关。
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引用次数: 0
A 60 Years Old Woman with Ganglion Cyst of Popliteus Tendon Sinistra 60岁女性腘肌腱腱鞘囊肿1例
Pub Date : 2022-11-30 DOI: 10.24853/mmj.3.2.47-52
Faricha Kurnia Illahi, Abdul Hakam Mubarak
The popliteal ganglion, also known as Baker's cyst, is an abnormal, fluid-filled distension of the gastrocnemius-semimembranosus bursa. These cysts rarely manifest alone and are often associated with intra-articular pathology and inflammatory conditions, such as osteoarthritis, meniscus tears, and rheumatoid arthritis. A 60-year-old woman came to the surgery clinic of Dr. Sayidiman Magetan hospital with complaints of lumps in the left knee crease. The patient noticed a lump in the crease of her left knee for two months. The patient said she did not feel pain in the lump, but the patient sometimes felt stiffness in the lump area when the patient worked in the fields. The localization status on inspection showed a mass in the popliteal area of the knee, which was round and well-defined. On palpation there is no pain, and can be moved mobile. Non-medical management is surgery/extirpation of the tumor mass.
腘神经节,又称贝克囊肿,是腓肠肌-半膜囊的异常充盈性扩张。这些囊肿很少单独出现,通常与关节内病理和炎症有关,如骨关节炎、半月板撕裂和类风湿关节炎。一位60岁的妇女来到Sayidiman Magetan医生医院的外科诊所,抱怨左膝皱褶有肿块。病人发现左膝皱褶处有个肿块,已经有两个月了。病人说她没有感觉到肿块的疼痛,但是当病人在田里工作时,病人有时会感到肿块区域僵硬。定位检查显示膝关节腘窝区有肿块,肿块圆形,轮廓清晰。触诊上没有疼痛感,且可移动可移动。非医疗处理是手术/切除肿瘤肿块。
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引用次数: 0
Nutritional Status and Severity of Pneumonia among Inpatient of Children Under Five Years 5岁以下住院儿童肺炎营养状况及严重程度分析
Pub Date : 2022-11-30 DOI: 10.24853/mmj.3.2.40-46
Dayu Swasti Kharisma, Balqis Al Sakina Zahra
Background: The prevalence of pneumonia in developing countries continues to increase, especially in Indonesia. One of the factors that influence the severity of pneumonia is nutritional status. Malnutrition increases susceptibility to infection. Purposes: This study aimed to determine the relationship between nutritional status and pneumonia severity in children under five. Methods: This research was an analytic study with a cross-sectional design. The data were taken from the medical records of pneumonia patients under five years of age who were hospitalized at the Infectious Disease Hospital Prof. Dr. Sulianti Saroso for January 2018 to October 2019. Bivariate analysis was performed using the chi-square test. Results: Out of 68 patients who met the inclusion criteria, the highest age range was 0-11 months (50%), the most gender was female (55.9%), the group with the highest cases was the severe pneumonia group (73.5%), the most nutritional status was abnormal nutrition (55.9%). There are 86.8% of patients with abnormal nutritional status suffer from severe pneumonia. Conclusion: There is a relationship between nutritional status and pneumonia severity.
背景:发展中国家的肺炎患病率持续上升,特别是在印度尼西亚。影响肺炎严重程度的因素之一是营养状况。营养不良会增加对感染的易感性。目的:本研究旨在确定营养状况与五岁以下儿童肺炎严重程度之间的关系。方法:采用横断面设计的分析研究。这些数据来自2018年1月至2019年10月在传染病医院Sulianti Saroso教授住院的5岁以下肺炎患者的医疗记录。采用卡方检验进行双变量分析。结果:符合纳入标准的68例患者中,年龄范围最大的为0 ~ 11月龄(50%),性别最多的为女性(55.9%),重症肺炎组病例最多(73.5%),营养状况异常最多(55.9%)。86.8%营养状况异常的患者发生重症肺炎。结论:营养状况与肺炎严重程度有关。
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引用次数: 0
Uric Acid Levels in Pregnant Women 孕妇的尿酸水平
Pub Date : 2022-11-30 DOI: 10.24853/mmj.3.2.53-59
Anastaysia Annisa Haribaik, H. Bekti, D. A. A. Posmaningsih
Background: Preeclampsia in pregnant women can be detected by measuring uric acid levels in the blood. This can occur due to changes in the hemodynamic system and decreased glomerular filtration rate during pregnancy. Purposes: This study aims to determine the description of uric acid levels in pregnant women at Community Health Centers I, South Denpasar. Methods: This study uses a descriptive observational method from April to May 2022, with 31 respondents obtained by non-probability sampling technique. Uric acid levels were measured by the Point of Care Testing (POCT) method. Results: The results showed 23 pregnant women (74.2%) with normal uric acid levels and eight pregnant women (25.8%) with high uric acid levels. Conclusion: High uric acid levels are most suffered by pregnant women aged 30 years (16.1%), most commonly found in the third trimester of pregnancy (16.1%), most pregnant women with a body mass index (BMI) more and obesity (9.7%), and pregnant women with normal blood pressure (22.6%).
背景:孕妇的先兆子痫可以通过测量血液中的尿酸水平来检测。这可能是由于怀孕期间血液动力学系统的改变和肾小球滤过率的降低而发生的。目的:本研究旨在确定在南登巴萨社区卫生中心I孕妇尿酸水平的描述。方法:本研究采用描述性观察法,于2022年4月至5月,采用非概率抽样技术获得31名调查对象。尿酸水平通过护理点测试(POCT)方法测量。结果:尿酸正常孕妇23例(74.2%),高尿酸孕妇8例(25.8%)。结论:高尿酸血症以30岁孕妇(16.1%)、妊娠晚期(16.1%)、体重指数(BMI)偏高和肥胖的孕妇(9.7%)、血压正常的孕妇(22.6%)最为常见。
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引用次数: 0
Nutritional Status and Diarrhea in Toddlers Aged 0 – 59 Months 0 - 59个月幼儿的营养状况和腹泻
Pub Date : 2022-11-30 DOI: 10.24853/mmj.3.2.60-66
Wafa Afrodita Kantri, Roito Elmina Gogo Harahap, Muhamad Arif Budiman
Background: Diarrhea is one of the diseases that ranks in the top ten diseases in Depok City. Data from the Depok City Health Service (2020) states that diarrhea in toddlers is still above 5%. There are various factors (multifactor) related to diarrhea disease, one of which is nutritional status. Purposes: Our study aims to analyze the relationship between nutritional status and diarrhea in toddlers in the Pancoran Mas District Health Center. Methods: We used an observational analytic method with a cross-sectional approach on 396 toddlers aged 0 – 59 months. This research was conducted from October 2021 – March 2022. The type of data in this study is secondary data taken through medical records and analyzed using the chi-square test. Result: The prevalence of low-poor nutritional status was 38,9%, the prevalence of diarrhea was 21,2%, and the results of the chi-square analysis between diarrhea and nutritional status obtained p value = 0.334. Conclusion: Incidence of diarrhea in Depok City is still relatively large. There are many other factors that associated with the incidence of diarrhea such as personal hygiene, environmental hygiene and various other factors.
背景:腹泻是德波市十大疾病之一。来自德波市卫生局(2020年)的数据显示,幼儿腹泻率仍高于5%。腹泻病与多种因素(多因素)有关,其中之一是营养状况。目的:本研究旨在分析潘可兰玛斯区卫生中心幼儿营养状况与腹泻的关系。方法:采用横断面观察分析法对396例0 ~ 59月龄幼儿进行分析。这项研究于2021年10月至2022年3月进行。本研究的数据类型为病历中的二次数据,采用卡方检验进行分析。结果:低-不良营养状况患病率为38.9%,腹泻患病率为21.2%,腹泻与营养状况卡方分析结果p值= 0.334。结论:德波市腹泻发病率仍较高。还有许多其他因素与腹泻的发病率有关,如个人卫生,环境卫生和各种其他因素。
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引用次数: 0
Perceptions of Medical Teachers and Students about Barriers and Capacities in Distance Learning 医学教师和学生对远程学习障碍和能力的看法
Pub Date : 2022-06-20 DOI: 10.24853/mmj.3.1.33-39
Oktarina Oktarina, Alidina Nur Afifah, Ahmad Fikri Adriansyah
Background: Currently, distance learning is booming and requires adaptation from students, teachers, and faculty. Identifying constraints is essential as inputs for faculty development. Purposes: to identify teacher and medical student perceptions of barriers and capacity in distance learning. Methods: This research was conducted using a cross-sectional survey of 42 medical teachers and 613 students Faculty Medicine and Health, Universitas Muhammadiyah Jakarta students. It utilized secondary data from the Quality Assurance Unit in October 2020. Six variables were studied in this research, i.e., technical constraints of distance learning, teachers' perceptions of the essential components in distance learning, student self-perceptions, teachers' and students' perceptions of web conference effectiveness, and teachers' self-perceptions and students' satisfaction. Results: The top 5 technical constraints of distance learning complained were signal interference, internet data plan, limited e-literatures, and lack of communication with the faculty. According to the teachers, the essential components were faculty commitment (90%), regulation (85%), technical support (79%), course management, and teaching-learning guidelines (77%). Most students experience learning difficulties during distance learning. However, only 45% of students felt their independent learning method is effective. Teachers and students agreed that web conferencing is ineffective for learning clinical skills but disagreed on cognitive knowledge. 74% of teachers stated that the presentation was engaging. Meanwhile, more than 25% of students were dissatisfied. Conclusion: The top 4 technical constraints were signal interference, internet data plan, limited e-literatures, and lack of communication with the faculty. The important components of distance learning were faculty commitment (90%), 83% of students experienced learning difficulties during distance learning.
背景:目前,远程学习正在蓬勃发展,需要学生、教师和教职员工的适应。确定约束条件对教师发展至关重要。目的:确定教师和医学生对远程学习障碍和能力的看法。方法:本研究采用横断面调查方法对雅加达穆罕默德大学医学与健康学院的42名医学教师和613名学生进行调查。它利用了2020年10月质量保证股的二手数据。本研究研究了6个变量,即远程学习的技术约束、教师对远程学习基本要素的感知、学生自我感知、教师和学生对网络会议有效性的感知、教师自我感知和学生满意度。结果:远程教育的五大技术制约因素为信号干扰、网络数据计划、电子文献有限和缺乏与教师的沟通。根据教师的说法,基本组成部分是教师承诺(90%),法规(85%),技术支持(79%),课程管理和教与学指导(77%)。大多数学生在远程学习中遇到学习困难。然而,只有45%的学生认为他们的自主学习方法是有效的。教师和学生一致认为网络会议对临床技能的学习无效,但在认知知识方面存在分歧。74%的教师认为报告很吸引人。与此同时,超过25%的学生不满意。结论:信号干扰、网络数据计划、电子文献有限、缺乏与教师的沟通是制约学生学习的四大技术因素。远程学习的重要组成部分是教师承诺(90%),83%的学生在远程学习中遇到学习困难。
{"title":"Perceptions of Medical Teachers and Students about Barriers and Capacities in Distance Learning","authors":"Oktarina Oktarina, Alidina Nur Afifah, Ahmad Fikri Adriansyah","doi":"10.24853/mmj.3.1.33-39","DOIUrl":"https://doi.org/10.24853/mmj.3.1.33-39","url":null,"abstract":"Background: Currently, distance learning is booming and requires adaptation from students, teachers, and faculty. Identifying constraints is essential as inputs for faculty development. Purposes: to identify teacher and medical student perceptions of barriers and capacity in distance learning. Methods: This research was conducted using a cross-sectional survey of 42 medical teachers and 613 students Faculty Medicine and Health, Universitas Muhammadiyah Jakarta students. It utilized secondary data from the Quality Assurance Unit in October 2020. Six variables were studied in this research, i.e., technical constraints of distance learning, teachers' perceptions of the essential components in distance learning, student self-perceptions, teachers' and students' perceptions of web conference effectiveness, and teachers' self-perceptions and students' satisfaction. Results: The top 5 technical constraints of distance learning complained were signal interference, internet data plan, limited e-literatures, and lack of communication with the faculty. According to the teachers, the essential components were faculty commitment (90%), regulation (85%), technical support (79%), course management, and teaching-learning guidelines (77%). Most students experience learning difficulties during distance learning. However, only 45% of students felt their independent learning method is effective. Teachers and students agreed that web conferencing is ineffective for learning clinical skills but disagreed on cognitive knowledge. 74% of teachers stated that the presentation was engaging. Meanwhile, more than 25% of students were dissatisfied. Conclusion: The top 4 technical constraints were signal interference, internet data plan, limited e-literatures, and lack of communication with the faculty. The important components of distance learning were faculty commitment (90%), 83% of students experienced learning difficulties during distance learning.","PeriodicalId":32215,"journal":{"name":"Journal of Muhammadiyah Medical Laboratory Technologist","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78297339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Muhammadiyah Medical Laboratory Technologist
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