Pub Date : 2022-07-31DOI: 10.20885/jif.vol18.iss1.art4
Wenti Yuliana, N. Idiawati, Dwi Imam Prayitno
{"title":"Pigment screening, phytochemical test, and cytotoxicity testing of the ethanol extract of Holothuria atra sea cucumber from Lemukutan island waters","authors":"Wenti Yuliana, N. Idiawati, Dwi Imam Prayitno","doi":"10.20885/jif.vol18.iss1.art4","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss1.art4","url":null,"abstract":"","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87097382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art2
Cahaya Rahayu Yuliani, H. Ramadhan, Putri Indah Sayakti, Cast Torizellia
Abstract Background: Binjai leaves (Mangifera caesia Jack. ex. Wall) or M. caesia contain phenolic and flavonoid compounds important in medicinal plants development. The solvent difference and fractionation will give various active substance concentrations. Objective: To evaluate the phenolic and flavonoid content qualitatively and quantitatively from the n-hexane fraction of binjai leaves methanol extract. Methods: The soxhletation method with methanol was used to extract binjai leaves followed by fractionation. Thin Layer Chromatography (TLC) followed by spraying reagents were used to test phenols and flavonoids compounds. Folin-Ciocalteu reagents were used to analyzed total phenolics, while AlCl3 reagents were used to quantify the total flavonoid content. Result: This study gave positive results on the qualitative test of phenolics and flavonoids. Meanwhile, the fraction assay results showed total phenolic levels of 45.19 µgGAE/mg and total flavonoid levels of 165.06 µgQE/mg. Conclusion: The n-hexane fraction of M. caesia leaves methanol extracts contains phenols and flavonoid content so that it has the potential as a medicinal plant. Keywords: Binjai leaves, methanol extracts, n-hexane fraction, phenol, flavonoid
{"title":"Total phenolic and flavonoid contents of n-hexane fraction in binjai leaves (Mangifera caesia Jack. ex. Wall)","authors":"Cahaya Rahayu Yuliani, H. Ramadhan, Putri Indah Sayakti, Cast Torizellia","doi":"10.20885/jif.specialissue2022.art2","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art2","url":null,"abstract":"Abstract Background: Binjai leaves (Mangifera caesia Jack. ex. Wall) or M. caesia contain phenolic and flavonoid compounds important in medicinal plants development. The solvent difference and fractionation will give various active substance concentrations. Objective: To evaluate the phenolic and flavonoid content qualitatively and quantitatively from the n-hexane fraction of binjai leaves methanol extract. Methods: The soxhletation method with methanol was used to extract binjai leaves followed by fractionation. Thin Layer Chromatography (TLC) followed by spraying reagents were used to test phenols and flavonoids compounds. Folin-Ciocalteu reagents were used to analyzed total phenolics, while AlCl3 reagents were used to quantify the total flavonoid content. Result: This study gave positive results on the qualitative test of phenolics and flavonoids. Meanwhile, the fraction assay results showed total phenolic levels of 45.19 µgGAE/mg and total flavonoid levels of 165.06 µgQE/mg. Conclusion: The n-hexane fraction of M. caesia leaves methanol extracts contains phenols and flavonoid content so that it has the potential as a medicinal plant. Keywords: Binjai leaves, methanol extracts, n-hexane fraction, phenol, flavonoid","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76277080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art20
Vivi Asfianti, Alfi Sapitri, Eva Diansari Marbun
Abstract Background: Attarasa (L.a cubeba (Lour.) Pers.) is a potential Indonesian medicinal plant that is used as a cold remedy, head ulcers, antimicrobials, antioxidants, and anticancer drugs. Objective: This research was conducted to analyze the immunomodulatory effect of bark (EEKBA) and fruit of attarasa ethanolic extract (EEBA) by detecting its phagocytosis activity in male mice using carbon clearance method. Method: Total of 24 male mice were divided into 6 groups. Extract was orally administered to mices for 7 days at the dose of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. Imboost® suspension at the dose of 32.5 mg/kg BW and CMC-Na 1 % suspension was orally administered in positive control, negative control and normal groups. On the 8th day, 0.1 ml carbon suspension was given through intravenous tail injection. The blood samples were withdrawn at 5, 10, 15, and 20 minutes after injection of carbon suspension to find out the carbon absorbance contained in the blood that was measured using spectrophotometer then the carbon elimination speed, phagocytic index, and the stimulation index has been calculated Result: EEKBA and EEBA at the dose of 400 mg/kg BW induced the higher carbon elimination rate in mice compared to EEKBA and EEBA dose of 100 and 200 mg/kg BW. Phagocytic index of macrophage in mice given with EEKBA and EEBA at dose of 100, 200, dan 400 mg/kg BW were 3.429, 3.501, and 3.925 for EEKBA consecutively; 4.289, 4.375 and 4.732 for EEBA respectively. Stimulation index of macrophage in mice given with EEKBA and EEBA at dose of 100, 200, and 400 mg/kg BW were 1.00; 1.20, 1,02; 1,23, and 1,13; 1,33. Based on the results of statistical test, EEKBA and EEBA administration at the dose of 100, 200, and 400 mg/kg BW stimulate the phagocytosis activity of the macrophage of male mice and significantly has different result compared to normal control group (p < 0.05). Phagocytosis activity was best shown at the mice group that administered EEKBA and EEBA at dose of 400 mg/kg BW and was shown not significantly different compared to positive control group (p > 0.05). Conclusion: EEKBA and EEBA have immunomodulatory effect by increasing the phagocytosis activity of mice. Keywords: immunomodulatory, Litsea cubeba, carbon clearance, phagocytosis activity
{"title":"The immunomodulatory activity of ethanol extract of attarasa bark and fruit (Litsea cubeba (lour.) pers.) toward carbon clearance of mice (Mus musculus)","authors":"Vivi Asfianti, Alfi Sapitri, Eva Diansari Marbun","doi":"10.20885/jif.specialissue2022.art20","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art20","url":null,"abstract":"Abstract Background: Attarasa (L.a cubeba (Lour.) Pers.) is a potential Indonesian medicinal plant that is used as a cold remedy, head ulcers, antimicrobials, antioxidants, and anticancer drugs. Objective: This research was conducted to analyze the immunomodulatory effect of bark (EEKBA) and fruit of attarasa ethanolic extract (EEBA) by detecting its phagocytosis activity in male mice using carbon clearance method. Method: Total of 24 male mice were divided into 6 groups. Extract was orally administered to mices for 7 days at the dose of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. Imboost® suspension at the dose of 32.5 mg/kg BW and CMC-Na 1 % suspension was orally administered in positive control, negative control and normal groups. On the 8th day, 0.1 ml carbon suspension was given through intravenous tail injection. The blood samples were withdrawn at 5, 10, 15, and 20 minutes after injection of carbon suspension to find out the carbon absorbance contained in the blood that was measured using spectrophotometer then the carbon elimination speed, phagocytic index, and the stimulation index has been calculated Result: EEKBA and EEBA at the dose of 400 mg/kg BW induced the higher carbon elimination rate in mice compared to EEKBA and EEBA dose of 100 and 200 mg/kg BW. Phagocytic index of macrophage in mice given with EEKBA and EEBA at dose of 100, 200, dan 400 mg/kg BW were 3.429, 3.501, and 3.925 for EEKBA consecutively; 4.289, 4.375 and 4.732 for EEBA respectively. Stimulation index of macrophage in mice given with EEKBA and EEBA at dose of 100, 200, and 400 mg/kg BW were 1.00; 1.20, 1,02; 1,23, and 1,13; 1,33. Based on the results of statistical test, EEKBA and EEBA administration at the dose of 100, 200, and 400 mg/kg BW stimulate the phagocytosis activity of the macrophage of male mice and significantly has different result compared to normal control group (p < 0.05). Phagocytosis activity was best shown at the mice group that administered EEKBA and EEBA at dose of 400 mg/kg BW and was shown not significantly different compared to positive control group (p > 0.05). Conclusion: EEKBA and EEBA have immunomodulatory effect by increasing the phagocytosis activity of mice. Keywords: immunomodulatory, Litsea cubeba, carbon clearance, phagocytosis activity","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83676200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art10
Warsinah Warsinah, Esti Dyah Utami, H. Baroroh
Background: Hepatotoxic effects can occur with the use of toxic drugs or standard doses, but in the long term or chronic therapy. In addition to the drugs, carrageenan also causes hepatotoxic after 12 hours of induction intraperitoneally. The effect of liver cell repair is highly related to the antioxidant activity of phenolic compounds in date seeds. Objective: The present study determined the total phenolic levels and hepatoprotective activity of ethanol extracts of date palm seeds (EEBK) in carrageenan-induced rats. Method: Determination of total phenolics in palm ethanol extract samples was carried out with the Folin- Ciocalteu reagent. This study was the pre and post-test control group design. Examination of SGOT and SGPT levels was performed by the kinetic method based on IFCC. Data was analyzed using paired t-test and ANOVA test. Results: The total phenolic content of the ethanol extract of date seeds of Deglet Noor variety was 8.521% GAE. The ethanol extract of date seed (EEBK) with the dose of 150 mg/kg BW showed the highest reduction in SGOT levels (34.80 U / L). The highest average decrease in SGPT levels occurred at a therapeutic dose of 300 mg/kg BW was 16.20 U / L compared to doses of 150 and 600 mg/kg bb (11.60 and 15.60 U / L respectively). Conclusion: The ethanol extract of date seed (EEBK) with the doses of 150, 300, and 600 mg/kg BW had hepatoprotective activity in carrageenan-induced rats as observed from a significant decreased in SGOT and SGPT levels (p <0.05). Key word: Date seed, phenolic total, extract, SGPT, SGOT
背景:使用有毒药物或标准剂量可发生肝毒性作用，但在长期或慢性治疗中。除药物外，角叉菜胶经腹腔诱导12小时后也会引起肝毒性。红枣种子中酚类化合物的抗氧化活性与肝细胞修复作用密切相关。目的:研究枣椰籽乙醇提取物(EEBK)对卡拉胶诱导大鼠总酚含量及肝保护作用的影响。方法:采用Folin- Ciocalteu试剂测定棕榈乙醇提取物中总酚类物质的含量。本研究采用测试前和测试后对照组设计。采用基于IFCC的动力学方法检测SGOT和SGPT水平。数据分析采用配对t检验和方差分析检验。结果:红枣种子乙醇提取物总酚含量为8.521%。与150和600 mg/kg bb(分别为11.60和15.60 U / L)相比，150 mg/kg BW剂量的枣籽乙醇提取物(EEBK)的SGOT水平降低幅度最大(34.80 U / L)， 300 mg/kg BW剂量的SGPT水平平均降低幅度最大(16.20 U / L)。结论:150、300和600 mg/kg BW剂量的枣籽乙醇提取物(EEBK)对角叉菜胶诱导的大鼠具有肝保护作用，显著降低SGOT和SGPT水平(p <0.05)。关键词:枣籽，总酚，提取物，SGPT, SGOT
{"title":"The phenolic compounds of ethanolic extract of date seed (Phoenix dactylifera L.) exert hepatoprotective activity on rat induced carragenan","authors":"Warsinah Warsinah, Esti Dyah Utami, H. Baroroh","doi":"10.20885/jif.specialissue2022.art10","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art10","url":null,"abstract":"Background: Hepatotoxic effects can occur with the use of toxic drugs or standard doses, but in the long term or chronic therapy. In addition to the drugs, carrageenan also causes hepatotoxic after 12 hours of induction intraperitoneally. The effect of liver cell repair is highly related to the antioxidant activity of phenolic compounds in date seeds. Objective: The present study determined the total phenolic levels and hepatoprotective activity of ethanol extracts of date palm seeds (EEBK) in carrageenan-induced rats. Method: Determination of total phenolics in palm ethanol extract samples was carried out with the Folin- Ciocalteu reagent. This study was the pre and post-test control group design. Examination of SGOT and SGPT levels was performed by the kinetic method based on IFCC. Data was analyzed using paired t-test and ANOVA test. Results: The total phenolic content of the ethanol extract of date seeds of Deglet Noor variety was 8.521% GAE. The ethanol extract of date seed (EEBK) with the dose of 150 mg/kg BW showed the highest reduction in SGOT levels (34.80 U / L). The highest average decrease in SGPT levels occurred at a therapeutic dose of 300 mg/kg BW was 16.20 U / L compared to doses of 150 and 600 mg/kg bb (11.60 and 15.60 U / L respectively). Conclusion: The ethanol extract of date seed (EEBK) with the doses of 150, 300, and 600 mg/kg BW had hepatoprotective activity in carrageenan-induced rats as observed from a significant decreased in SGOT and SGPT levels (p <0.05). Key word: Date seed, phenolic total, extract, SGPT, SGOT","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89966871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art14
A. Rasyad, A. Aisah, Lidia Lidia, Sari Meisyayati
Abstract Background: Previously, the activity test of the combination herbal juice of garlic, rosella flower, red ginger, lime, apple cider vinegar, and honey, combined herbal juice can lower blood sugar [1] and can reduce total cholesterol levels [11]. In the use of traditional medicine and its effectiveness, its safety must also be proven before herbal juices are circulated in the community Objective: This study was to determine the subacute hepatotoxic effect of the combination herbal juice Method: This research is an experimental study using 24 rats divided into four groups. Namely, the control group was given distilled water, and the group was given the combination herbal juice at a dose of 28, 14, and 7 mg/kg BW/day for 28 days. The measurement parameters were the increased activity of SGOT and SGPT and histopathological features of liver cells. The data were statistically analyzed with one-way ANOVA analysis Results: The administration of combination herbal juice for 28 days at a dose of 28, 14, and 7 mg/kg BW/day did not increase SGOT activity but caused a significant decrease in SGPT levels, namely by 20.34%, 19.39%, and 15.30%. From the histopathological picture of liver cells, at a dose of 28 mg/kg BW/day, there was no histopathological damage to liver cells Conclusion: Subacute administration of combined herbal juice did not cause hepatotoxicity in Wistar male white rats Keywords: Combination herbal juice, subacute toxicity, histopathology, SGOT, and SGPT
{"title":"Sub chronic toxicity effect of combination of herbal juice on the function and 2 histopathology feature of male Wistar rat liver","authors":"A. Rasyad, A. Aisah, Lidia Lidia, Sari Meisyayati","doi":"10.20885/jif.specialissue2022.art14","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art14","url":null,"abstract":"Abstract Background: Previously, the activity test of the combination herbal juice of garlic, rosella flower, red ginger, lime, apple cider vinegar, and honey, combined herbal juice can lower blood sugar [1] and can reduce total cholesterol levels [11]. In the use of traditional medicine and its effectiveness, its safety must also be proven before herbal juices are circulated in the community Objective: This study was to determine the subacute hepatotoxic effect of the combination herbal juice Method: This research is an experimental study using 24 rats divided into four groups. Namely, the control group was given distilled water, and the group was given the combination herbal juice at a dose of 28, 14, and 7 mg/kg BW/day for 28 days. The measurement parameters were the increased activity of SGOT and SGPT and histopathological features of liver cells. The data were statistically analyzed with one-way ANOVA analysis Results: The administration of combination herbal juice for 28 days at a dose of 28, 14, and 7 mg/kg BW/day did not increase SGOT activity but caused a significant decrease in SGPT levels, namely by 20.34%, 19.39%, and 15.30%. From the histopathological picture of liver cells, at a dose of 28 mg/kg BW/day, there was no histopathological damage to liver cells Conclusion: Subacute administration of combined herbal juice did not cause hepatotoxicity in Wistar male white rats Keywords: Combination herbal juice, subacute toxicity, histopathology, SGOT, and SGPT","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90079736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art7
Reza Agung Sriwijaya
Background: Pharmaceutical services play an important role in the success of patient treatment in health centers, therefore it is necessary to evaluate the management of pharmaceutical preparations and clinical pharmacy services and see the level of patient satisfaction and waiting time for prescriptions in health centers by comparing those stipulated in the regulation of the minister of health no 74 of 2016 and no 129 year 2008 Objective: The purpose of this study was to evaluate the management of Consumable Medical Materials (BMHP) services, clinical pharmacy services based on Minister of Health Regulation No. 74 /2016 and Permenkes no 129/2008. Methods : This research is an observational, experimental, quantitative descriptive, cross-sectional study with prospective data collection, survey methods and interviews. Measuring instrument research, questionnaire sheet, which has been validated. Inclusion criteria are pharmacy staff who are responsible for pharmacy services at Betung Public Health Center, Banyuasin Regency. The data obtained in the form of qualitative and quantitative descriptive data. Result : The results of the study obtained services according to Permenkes No. 74 of 2016 management of pharmaceutical preparations and medical consumables of 88.26% (good) and clinical pharmacy services 26.2% (less) especially in Drug Information Services (PIO), Monitoring of Side Effects Drugs (MESO), and Drug Therapy Monitoring (PTO), the visits have not been carried out, patients are very satisfied with the services of the Betung Health Center and the average waiting time for prescription services is 4 minutes 13 seconds according to the Regulation of the Minister of Health No. 129 Year 2008. Conclusion : Pharmaceutical services that are in accordance with Permenkes No.74 of 2016 on the management of pharmaceutical preparations and BMHP are in accordance with 88.26% but clinical pharmacy services are not in accordance with Permenkes 74/2016 by 21.3% (less category), especially in clinical pharmacy services which What has not been implemented is drug information service (PIO) by 33.05% and what has not been implemented, namely monitoring of drug side effects (MESO) and monitoring of drug therapy (PTO), Visit by 0%. The level of patient satisfaction is very satisfied with the puskesmas services with a percentage of 81.3% seen from the 5 dimensions, the average value of waiting time for prescription services is 4 minutes 13 seconds according to the Ministry of Health no. 129 in 2008. Keywords: puskesmas, pharmaceutical services, Permenkes
{"title":"Evaluasi pelayanan kefarmasian dan mengukur tingkat kepuasan, waktu tunggi pelayanan resep dokter di puskesmas betung kota kabupaten banyuasin","authors":"Reza Agung Sriwijaya","doi":"10.20885/jif.specialissue2022.art7","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art7","url":null,"abstract":"Background: Pharmaceutical services play an important role in the success of patient treatment in health centers, therefore it is necessary to evaluate the management of pharmaceutical preparations and clinical pharmacy services and see the level of patient satisfaction and waiting time for prescriptions in health centers by comparing those stipulated in the regulation of the minister of health no 74 of 2016 and no 129 year 2008 Objective: The purpose of this study was to evaluate the management of Consumable Medical Materials (BMHP) services, clinical pharmacy services based on Minister of Health Regulation No. 74 /2016 and Permenkes no 129/2008. Methods : This research is an observational, experimental, quantitative descriptive, cross-sectional study with prospective data collection, survey methods and interviews. Measuring instrument research, questionnaire sheet, which has been validated. Inclusion criteria are pharmacy staff who are responsible for pharmacy services at Betung Public Health Center, Banyuasin Regency. The data obtained in the form of qualitative and quantitative descriptive data. Result : The results of the study obtained services according to Permenkes No. 74 of 2016 management of pharmaceutical preparations and medical consumables of 88.26% (good) and clinical pharmacy services 26.2% (less) especially in Drug Information Services (PIO), Monitoring of Side Effects Drugs (MESO), and Drug Therapy Monitoring (PTO), the visits have not been carried out, patients are very satisfied with the services of the Betung Health Center and the average waiting time for prescription services is 4 minutes 13 seconds according to the Regulation of the Minister of Health No. 129 Year 2008. Conclusion : Pharmaceutical services that are in accordance with Permenkes No.74 of 2016 on the management of pharmaceutical preparations and BMHP are in accordance with 88.26% but clinical pharmacy services are not in accordance with Permenkes 74/2016 by 21.3% (less category), especially in clinical pharmacy services which What has not been implemented is drug information service (PIO) by 33.05% and what has not been implemented, namely monitoring of drug side effects (MESO) and monitoring of drug therapy (PTO), Visit by 0%. The level of patient satisfaction is very satisfied with the puskesmas services with a percentage of 81.3% seen from the 5 dimensions, the average value of waiting time for prescription services is 4 minutes 13 seconds according to the Ministry of Health no. 129 in 2008. Keywords: puskesmas, pharmaceutical services, Permenkes","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84353602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art4
N. Gunarti, Himyatul Hidayah
Abstract Background: Hyperuricemia is a condition where uric acid levels in the blood increase more than 6 mg/dL. Tapak liman (Elephantopus scaber) contains flavonoid compounds that are reported to inhibit the activity of the xanthine oxidase enzyme that causes hyperuricemia. Several Asteraceae tribes have activity as antihyperuricemia, one of which is the tapak liman plant (E. scaber) because of the compounds contained in the flavonoid group which has a working mechanism as an inhibitor of the xanthine oxidase enzyme. Objective: To determine the types of flavonoid compounds in tapak liman (E. scaber) plants that have antihyperuricemic activity. Method: This research is qualitative research using Literature Review Article (LRA) using Google Scholar, PubMed, ResearchGate, and Science direct databases with keywords related to the research topic, namely "Elephantopus scaber, antihyperuricemia, tapak liman, xanthine oxidase, flavonoids". Results: Compounds from the flavonoid group in tapak liman that have the potential as antihyperuricemia are luteolin compounds, luteolin-7-glucoside, quercetin, and rutin with the mechanism of inhibiting the activity of the xanthine oxidase enzyme. Conclusion: compounds from the flavonoid group in tapak liman that have the potential as antihyperuricemic compounds are luteolin, luteolin-7-glucoside, quercetin, and rutin. Keywords: Elephantopus scaber, antihyperuricemia, tapak liman, xanthine oxidase, flavonoids
{"title":"Flavonoid compounds of tapak liman plant (Elephantopus scaber) as antihyperuricemia","authors":"N. Gunarti, Himyatul Hidayah","doi":"10.20885/jif.specialissue2022.art4","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art4","url":null,"abstract":"Abstract Background: Hyperuricemia is a condition where uric acid levels in the blood increase more than 6 mg/dL. Tapak liman (Elephantopus scaber) contains flavonoid compounds that are reported to inhibit the activity of the xanthine oxidase enzyme that causes hyperuricemia. Several Asteraceae tribes have activity as antihyperuricemia, one of which is the tapak liman plant (E. scaber) because of the compounds contained in the flavonoid group which has a working mechanism as an inhibitor of the xanthine oxidase enzyme. Objective: To determine the types of flavonoid compounds in tapak liman (E. scaber) plants that have antihyperuricemic activity. Method: This research is qualitative research using Literature Review Article (LRA) using Google Scholar, PubMed, ResearchGate, and Science direct databases with keywords related to the research topic, namely \"Elephantopus scaber, antihyperuricemia, tapak liman, xanthine oxidase, flavonoids\". Results: Compounds from the flavonoid group in tapak liman that have the potential as antihyperuricemia are luteolin compounds, luteolin-7-glucoside, quercetin, and rutin with the mechanism of inhibiting the activity of the xanthine oxidase enzyme. Conclusion: compounds from the flavonoid group in tapak liman that have the potential as antihyperuricemic compounds are luteolin, luteolin-7-glucoside, quercetin, and rutin. Keywords: Elephantopus scaber, antihyperuricemia, tapak liman, xanthine oxidase, flavonoids","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86985297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art19
Rini Isromarina, Doddy Rusli, Deva Ulan Sari
Background: Avocado is a plant that can grow in tropical climates. In general, people only consume the fruit while the skin and seeds are not used. Avocado fruit, skin and seeds contain secondary metabolites such as flavonoids and tannins which have antioxidant activity. Objective: To determine antioxidant activity, total flavonoid, and total tannin content of the ethanol extract of avocado peel. Methods: P. americana Mill. was collected from Lubuk Linggau, South Sumatra. The ethanol extract of P. americana Mill. peel obtained by maceration with ethanol. Qualitative analysis of flavonoids using Mg and HCl while tannins using FeCl3. Determination of total flavonoid content was carried out with AlCl3 reagent and Folin-Ciocalteu reagent to determine the total tannin content and was measured by a UV-Vis Spectrophotometer. Determination of antioxidant activity using the DPPH method. Result: The results of the qualitative analysis showed that ethanol extract of avocado peel contained flavonoids and tannins. It also had antioxidant activity with IC50 of 41,93 µg/mL. The total flavonoid and tannin content of it were 125,01 mgQE/g extract and 53,82 mgTAE/g extract respectively. Conclusion: Ethanol extract of avocado peel had antioxidant activity, while the total flavonoid compounds was higher than the total tannins. Keywords: antioxidant, DPPH, total flavonoid, total tannins
{"title":"Antioxidant activity, total flavonoid, and total tannin content of ethanol extract of avocado peel (Persea americana Mill.)","authors":"Rini Isromarina, Doddy Rusli, Deva Ulan Sari","doi":"10.20885/jif.specialissue2022.art19","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art19","url":null,"abstract":"Background: Avocado is a plant that can grow in tropical climates. In general, people only consume the fruit while the skin and seeds are not used. Avocado fruit, skin and seeds contain secondary metabolites such as flavonoids and tannins which have antioxidant activity. Objective: To determine antioxidant activity, total flavonoid, and total tannin content of the ethanol extract of avocado peel. Methods: P. americana Mill. was collected from Lubuk Linggau, South Sumatra. The ethanol extract of P. americana Mill. peel obtained by maceration with ethanol. Qualitative analysis of flavonoids using Mg and HCl while tannins using FeCl3. Determination of total flavonoid content was carried out with AlCl3 reagent and Folin-Ciocalteu reagent to determine the total tannin content and was measured by a UV-Vis Spectrophotometer. Determination of antioxidant activity using the DPPH method. Result: The results of the qualitative analysis showed that ethanol extract of avocado peel contained flavonoids and tannins. It also had antioxidant activity with IC50 of 41,93 µg/mL. The total flavonoid and tannin content of it were 125,01 mgQE/g extract and 53,82 mgTAE/g extract respectively. Conclusion: Ethanol extract of avocado peel had antioxidant activity, while the total flavonoid compounds was higher than the total tannins. Keywords: antioxidant, DPPH, total flavonoid, total tannins","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87610769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art6
Yopi Rikmasari
Abstract Background: Treatment adherence is an important factor affecting blood pressure control in hypertensive patients. Intervention in pharmacy service can improve medication adherence and lower blood pressure. Objective: This study aimed to evaluate the effect of drug information service using leaflets and MRC on the level of patient compliance and lowering blood pressure. Method: The research design was a quasi-experimental pre-and post-design with control, the intervention group (n=20), and the control group (n=20). The patient adherence was measured using the MGLS questionnaire at the beginning and the end of the study. The intervention was performed by distributing a drug information leaflet and medication reminder chart (MRC). The differences of adherence pre and post-intervention were analyzed using paired t-test, while the differences in adherence and blood pressure between the control and the intervention group were analyzed using the Mann-Whitney test. Results: The results showed that there was a significant difference in adherence between pre and post-intervention (p<0.001). A significant difference was also found in the level of adherence between the control group and the intervention group (p<0.001). Whereas the decrease of systolic (p=0.396) and diastolic (p=0.564) blood pressure in the intervention group and control group was not different significantly. Conclusion: Drug information services using leaflets and MRCs affected patient adherence to medication, but did not interfere with the decrease of systolic and diastolic blood pressure. Keywords: leaflets, medication reminder chart, adherence, blood pressure
{"title":"The effect of drug information service using leaflet media and medication reminder chart on adherence and blood pressure of hypertensive patients in primary health care","authors":"Yopi Rikmasari","doi":"10.20885/jif.specialissue2022.art6","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art6","url":null,"abstract":"Abstract Background: Treatment adherence is an important factor affecting blood pressure control in hypertensive patients. Intervention in pharmacy service can improve medication adherence and lower blood pressure. Objective: This study aimed to evaluate the effect of drug information service using leaflets and MRC on the level of patient compliance and lowering blood pressure. Method: The research design was a quasi-experimental pre-and post-design with control, the intervention group (n=20), and the control group (n=20). The patient adherence was measured using the MGLS questionnaire at the beginning and the end of the study. The intervention was performed by distributing a drug information leaflet and medication reminder chart (MRC). The differences of adherence pre and post-intervention were analyzed using paired t-test, while the differences in adherence and blood pressure between the control and the intervention group were analyzed using the Mann-Whitney test. Results: The results showed that there was a significant difference in adherence between pre and post-intervention (p<0.001). A significant difference was also found in the level of adherence between the control group and the intervention group (p<0.001). Whereas the decrease of systolic (p=0.396) and diastolic (p=0.564) blood pressure in the intervention group and control group was not different significantly. Conclusion: Drug information services using leaflets and MRCs affected patient adherence to medication, but did not interfere with the decrease of systolic and diastolic blood pressure. Keywords: leaflets, medication reminder chart, adherence, blood pressure","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84316721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.20885/jif.specialissue2022.art1
F. Cesa, Martanty Aditya, Rehmadanta Sitepu, D. Notario
Abstract Background: The administration of angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) therapy is known to have a side effect of a dry cough that would trigger OSA. Further research is needed to compare the effect of these two drugs on the side effects of OSA, which could trigger high-risk patient conditions. Objective: To determine the risk of using ACE and CCB on the incidence of OSA using a case-control study method at Dau Primary Health Center. Methods: Demographic data were collected on 207 respondents aged 40-60 years by collecting Data Collection Sheets and Berlin questionnaires to determine the risk of OSA in respondents. Then, statistical analysis was carried out by determining the odds ratio (OR). Results: The results showed that one of the factors BMI (obese BMI; OR=1.33; 95% CI=0.11-15.70) induces OSA with the highest OR value compared to other factors. Conclusion: Obese patient has a 1.33 times greater risk of OSA with ACEI and CCB therapy than non-obese. It is necessary to conduct further research with a larger sample size related to OSA’s assessment associated with this therapy to improve patients’ quality of life. Keywords: Obstructive sleep apnea, ACE inhibitors, calcium channel blockers, hypertension
{"title":"The risk of Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB) used on Obstructive Sleep Apnea (OSA) incidence in hypertension patients","authors":"F. Cesa, Martanty Aditya, Rehmadanta Sitepu, D. Notario","doi":"10.20885/jif.specialissue2022.art1","DOIUrl":"https://doi.org/10.20885/jif.specialissue2022.art1","url":null,"abstract":"Abstract Background: The administration of angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) therapy is known to have a side effect of a dry cough that would trigger OSA. Further research is needed to compare the effect of these two drugs on the side effects of OSA, which could trigger high-risk patient conditions. Objective: To determine the risk of using ACE and CCB on the incidence of OSA using a case-control study method at Dau Primary Health Center. Methods: Demographic data were collected on 207 respondents aged 40-60 years by collecting Data Collection Sheets and Berlin questionnaires to determine the risk of OSA in respondents. Then, statistical analysis was carried out by determining the odds ratio (OR). Results: The results showed that one of the factors BMI (obese BMI; OR=1.33; 95% CI=0.11-15.70) induces OSA with the highest OR value compared to other factors. Conclusion: Obese patient has a 1.33 times greater risk of OSA with ACEI and CCB therapy than non-obese. It is necessary to conduct further research with a larger sample size related to OSA’s assessment associated with this therapy to improve patients’ quality of life. Keywords: Obstructive sleep apnea, ACE inhibitors, calcium channel blockers, hypertension","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81125634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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