Kartika Jurnal Ilmiah Farmasi最新文献

{"title":"EFEKTIVITAS KOMBINASI EKSTRAK ETANOL 70% DAUN RAMANIA (Bouea macrophylla Griffith) dan GLIBENKLAMID DENGAN METODE INTOLERANSI GLUKOSA","authors":"K. Astuti, Fitriyanti' Fitriyanti', Hadirvika Tjuthiyanda","doi":"10.20885/jif.specialissue2023.art4","DOIUrl":"https://doi.org/10.20885/jif.specialissue2023.art4","url":null,"abstract":"Latar belakang: Diabetes  Melitus  merupakan kondisi  kronis  yang disebabkan kurang efektifnya insulin bekerja. Glibenklamid merupakan salah satu OHO yang sering digunakan baik dalam sediaan tunggal ataupun kombinasi. ramania (Bouea macrophylla Griffith) merupakan tanaman khas Kalimantan yang dapat digunakan sebagai pengobatan diabetes \u0000Tujuan: mengetahui konsentrasi terbaik dari kombinasi ekstrak etanol 70% daun ramania dengan glibenklamid sebagai antidiabetes. \u0000Metode: uji  intoleransi  glukosa  oral (UIGO). Hewan uji menggunakan mencit putih jantan yang dibagi menjadi masing-masing kelompok kontrol (Na-CMC 0,5%), kontrol, kontrol positif (glibenklamid 5 mg/kg BB), kelompok  kombinasi  ekstrak  etanol  70% daun  ramania  125;250; dan 500  mg/kgBB - glibenklamid 5 mg/kg BB. Mencit diinduksi glukosa secara oral agar mengalami hiperglikemia. Kadar glukosa darah pada menit ke-0, 30, 60, 90, 120 setelah induksi glukosa. \u0000Hasil: kombinasi ekstrak dan glibenklamid dengan dosis 250 dan 500 mg/KgBB menunjukkan efek antihiperglikemik. \u0000Kesimpulan: Diperoleh kombinasi terbaik dengan dosis 500 mg/KgBB yang dikombinasikan dengan glibenklamid","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74852692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALISIS KUALITAS PELAYANAN KEFARMASIAN DAN TINGKAT KEPUASAN PASIEN BADAN PENYELENGGARA JAMINAN SOSIAL ( BPJS) DI RSUD HADJI BOEJASIN PELAIHARI","authors":"Depy Oktapian Akbar, Rahmayanti Fitriah, Muhammad Luthfi Aditya, Reny Marliadi, Wahyudi, Aesty Rahayu","doi":"10.20885/jif.specialissue2023.art13","DOIUrl":"https://doi.org/10.20885/jif.specialissue2023.art13","url":null,"abstract":"Background: Pharmaceutical services are services that are provided directly and responsibly to patients, related to medicines to reach accurate results that enhance patient quality of life. \u0000Objective: The purpose of this research is to the analysis of the quality of pharmaceutical services and the level of satisfaction of BPJS patients at Hadji Boejasin Pelaihari Hospital. \u0000Method: A cross-sectional survey design with a targeted sampling design was used in this study. The research method was a questionnaire containing structured questions to quantify each variable studied. \u0000Results: Quality survey results pharmaceutical services were 85.96% (according) and 14.03% (not appropriate), while patient satisfaction with reliability dimension 78.63% (very satisfied), Responsiveness 77.82% (very satisfied) , Assurance 83.01% (very satisfied), Empathy 80.47% (very satisfied), and Tangible 82.53% (very satisfied). \u0000Conclusion: From the average of the five dimensions, a result of 547,4 was obtained with an average patient satisfaction index of 80,49% \u0000Keywords: BPJS, Service Quality, Satisfaction Level","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76320983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of conformity of the pharmaceutical service in Puskesmas Bogor City towards PMK No. 74, 2016","authors":"Nhadira Nhestricia, Hero Prasetio Kusworo, Lusi Agus Setiani","doi":"10.20885/jif.specialissue2023.art12","DOIUrl":"https://doi.org/10.20885/jif.specialissue2023.art12","url":null,"abstract":"Background: Improving the quality of pharmaceutical services requires a change in the old product-oriented paradigm (drug-oriented) into a new patient-oriented paradigm (patient-oriented) by executing pharmaceutical care. Improving the quality of pharmaceutical services to people who have direct contact through primary health care as the first-level health facility refers to PMK No. 74 of 2016.Objective: This study aims to determine the description of the implementation of pharmaceutical service standards at the Primary Health care facility in Bogor City for the 2022 period based on PMK No. 74 of 2016.Method: This study used a descriptive approach with an exploratory research type. Retrieval of data using questionnaire instruments and observation checklists The research was conducted for six months, from April to September 2022. The population in this study (24 primary health care and 24 pharmacy installation heads as respondents).Results: Based on the research results, the description of the implementation of pharmaceutical service standards at Bogor City Primary Health Care, based on PMK No. 74 of 2016, for the 2022 period showed that the average value of the questionnaire and observation instruments in the fields of management of pharmaceutical supplies and medical consumables (BMHP), clinical pharmacy services, and pharmaceutical quality control had successive values of 94.87, 85.5, and 100% (very good). The results of the value of the availability of pharmaceutical human resources were 95.83% (very good).Conclusion: The conclusion of the implementation of pharmaceutical services at the Bogor City Primary Health Care is in accordance with the pharmaceutical service standards at the Primary Health Care based on PMK No. 74 of 2016.\u0000Intisari Latar belakang: Peningkatan kualitas pelayanan kefarmasian menuntut adanya perubahan paradigma lama yang berorientasi terhadap produk (drug oriented) menjadi paradigma berkembang pada era saat ini yang berorientasi pada pasien (patient oriented) dengan melaksanakan pharmaceutical care. Peningkatan kualitas pelayanan kefarmasian pada masyarakat yang berhubungan langsung melalui puskesmas sebagai fasilitas kesehatan tingkat pertama yang merujuk pada PMK No. 74 Tahun 2016. Tujuan: Penelitian ini bertujuan untuk mengkaji kesesuaian implementasi standar pelayanan kefarmasian di Puskesmas Kota Bogor terhadap PMK No 74 Tahun 2016.Metode: Penelitian ini menggunakan pendekatan deskriptif dengan jenis penelitian eksploratif. Pengambilan data menggunakan instrumen kuisioner dan daftar tilik observasi. Penelitan dilakukan selama 6 bulan sejak April – September 2022. Populasi dalam penelitian ini adalah kepada kepala instalasi farmasi di seluruh Puskesmas Kota Bogor.Hasil: Implementasi standar pelayanan kefarmasian Puskesmas Kota Bogor berdasarkan PMK No. 74 tahun 2016 periode 2022 didapatkan hasil nilai rata-rata instrumen kuesioner dan observasi di bidang Pengelolaan Sediaan Farmasi dan Bahan Medis Habis Pakai (BMHP), ","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75470333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis determinan terhadap Length of Stay (LoS) di ruang isolasi Covid-19 RSUD Jend. A. Yani Kota Metro","authors":"Devina Harti Syaputri, D. Laksmitawati, P. Sarnianto, Andreas Infianto","doi":"10.20885/jif.vol19.iss1.art7","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art7","url":null,"abstract":"Intisari Latar belakang: Angka kejadian Coronavirus Disease 2019 (COVID-19) yang mengalami peningkatan di Indonesia mempengaruhi kebutuhan layanan rawat inap rumah sakit. Salah satu parameter mutu layanan dan penggunaan sumber daya rumah sakit adalah length of stay (LOS).Tujuan: Untuk mencari determinan COVID-19 yang berpengaruh terhadap LOS di rumah sakit.Metode: Pengambilan data secara retrospektif observasional menggunakan desain studi cross sectional. Metode pengambilan sampel menggunakan total sampling selama periode rawat Januari-Agustus 2021 di Ruang Isolasi RSUD Jend. A. Yani Kota Metro. Data yang digunakan adalah data rekam medis. Analisis bivariat dengan menggunakan Chi Square, sedangkan analisis multivariat menggunakan Regresi Logistik Ganda.Hasil: Sampel berjumlah 443 pasien yang di rawat selama periode Januari-Agustus 2021 di ruang isolasi COVID-19 RSUD Jend. A. Yani Kota Metro. Median LOS adalah 6 hari. Analisis regresi logistik ganda menunjukkan bahwa determinan LOS meliputi; tingkat keparahan, diabetes mellitus, penyakit jantung, D-Dimer.Kesimpulan: Tingkat keparahan, komorbid diabetes mellitus, komorbid penyakit jantung, nilai D-Dimer merupakan determinan terhadap LOS pasien COVID-19 terkonfirmasi di ruang isolasi COVID-19 RSUD Jenderal Ahmad Yani Provinsi Lampung.Kata kunci: Determinan, Coronavirus Disease, LOS, rumah sakit","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81222973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and development of UV-Vis spectrophotometer analysis methods for alpha-tocopherol acetate","authors":"Arif Al Iman, Winni Auli, S. Sukrasno","doi":"10.20885/jif.vol19.iss1.art8","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art8","url":null,"abstract":"Background: The COVID-19 pandemic had caused the consumption of vitamins in the community to increase with the aim of maintaining immunity in the body. Objective: This study aims to develop an analysis method with a UV-Vis spectrophotometer, which is considered an alternative analysis method that is easier, more practical, and cheaper. Method: Methods for analyzing alpha-tocopherol acetate are validated through specificity tests, linearity measurements, precision tests, accuracy tests, determination of detection limits, determination of quantitation limits, and determination of range using ethanol p.a solvent and UV-Vis Spectrophotometer instruments. Then, examine the alpha tocopherol acetate content of vitamin E dietary supplements. Results: The specificity test showed that matrix had no significant effect on the analysis, the linearity test met the requirements with a concentration range of 20–60 ug/mL (r = 0.9991), the accuracy test was 99.897-100.315%, intraday and interday precision tests were obtained with %RSD less than 2%, the LOD value was 1.859 ug/mL and the LOQ value was 5.635 ug/mL. The determination of levels of vitamin E in dietary supplements showed levels for brand A of 100.508% and brand B of 100.089%. Conclusion: The analytical method developed had met the validation requirements, and the levels of vitamin E food supplements had met the USP requirements. Keywords: method validation, UV-Vis spectrophotometer, alpha tocopherol acetate","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"76 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78139741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality and Antioxidant Activity of Faloak (Sterculia quardifida R.Br) Extract Syrup with Variations in Addition of Ginger (Zingiber officinale Roscoe)","authors":"P. Tenda, Lely A. V. Kapitan, Maria I. M. Indrawati, F. R. Soeharto","doi":"10.20885/jif.vol19.iss1.art2","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art2","url":null,"abstract":"Background: Faloak is known to contain flavonoids, terpenoids, phenols, and tannins, all of which have antioxidant activity. The preparation of faloak in the dosage form of syrup has been completed, but the suboptimal extraction of the active ingredient reduces the antioxidant activity of the syrup. In this study, the syrup was created by macerating extracts of faloak and red ginger, which contain active substances. The quality of the syrup is further evaluated for its antioxidant activity. Objective: To determine the characteristics of the extract, the quality of the syrup, and the antioxidant activity of the syrup. Method: During extraction using the maceration technique, both specific and non-specific characteristics of the extract are evaluated. The 2,2-diphenyl-1-picrilhydrazyl (DPPH) method was used to measure antioxidant activity. Results: The results of testing particular properties revealed that faloak and red ginger extracts contained flavonoids, triterpenoids, phenols, and tannins. The faloak and red ginger extracts had a water content of 5.926 ± 0.116 and 4.270 ± 0.121, respectively, and a total ash content of 2.430 ± 0.160 and 3.570 ± 0.140, according to non-specific analyses of the extract. The IC50 values for the antioxidant activity of formula 1 and formula 2 syrups were 114.002 ± 0.174 and 107.888 ± 0.115 ppm, respectively. Conclusion: The addition of red ginger to Faloak syrup increases its antioxidant activity compared to that of the syrup without the addition of red ginger, although both syrups have moderate antioxidant activity. Keywords: Faloak, syrup, antioxidant, DPPH","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84696601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of ethanol extract, n-hexane, and the ethyl acetate fraction of tin leaves (Ficus carica l.) on MCF-7 breast cancer cell lines","authors":"Aji Winanta, Widhi Yana Sari","doi":"10.20885/jif.vol19.iss1.art4","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art4","url":null,"abstract":"Background: Breast cancer is ranked as the second-highest cause of death in Indonesia. Many of the available cancer treatments result in severe adverse effects for patients. Tin (Ficus carica L.) leaves contain ingredients that can function as anticancer agents. Objective: The study aims to identify phytochemical secondary metabolites in tin leaves and the cytotoxic activity of the extract and tin leaf fraction on MCF-7 cells. Method: Tin leaf powder was macerated with 70% ethanol for 7 days. The extracts were fractionated using n-hexane and ethyl acetate. An identification test with ethanol extract was then carried out using spray reagents. The cytotoxic activity of ethanolic extract, n-hexane and ethyl acetate fraction of tin leaf was determined using the MTT method. Result: The results of the identification with TLC found that the ethanol extract of tin leaves contains flavonoids and steroids. The ethyl acetate fraction of tin leaf was thought to have weak cytotoxic properties with an IC50 value of 274.5877 ug/mL while the ethanol extract and n-heksan fraction of tin leaf do not have cytotoxic properties because they have an IC50 value of 562.827 and 576.3552 ug/mL. Conclusion: Based on the results, tin leaves have the potency to be developed as a chemopreventive agent for MCF-7 breast cancer cells. Keywords: Breast Cancer, MCF-7 cells, tin leaf (Ficus carica), cytotoxic activity","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80995601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug utilization pattern and cost estimates of antihypertensive drugs in pharmacies BPJS Kesehatan back-referral program in Kudus Regency","authors":"Wildayanti Wildayanti, Tri Wijayanti, T. Andayani","doi":"10.20885/jif.vol19.iss1.art3","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art3","url":null,"abstract":"Background: Hypertension is one of the main causes of mortality and morbidity in Indonesia. Drug usage, utilization patterns, and cost estimates are important elements in calculating drug needs in the forecasting of drug needs plans for pharmacies. Objective: to determine the pattern of drug use with the Anatomical Therapeuetik Chemical (ATC)/Defined Daily Dose (DDD) and Drug Use 90% (DU90%) methods and the estimated cost of antihypertensives with the use of antihypertensive drugs based on the national formulary. Methods: This research uses observational methods using a cross-sectional design. Retrospective data collection includes prescription from BPJS Kesehatan back-referral program (PRB) which goes into pharmacy A, B, and C for the period 2020. Results: The most widely used drugs at pharmacy A, B and C based on ATC/DDD classification were amlodipine, candesartan, ramipril, hydrochlorothiazide, and lisinopril. Amlodipine was the most frequent drug in the DU segment 90%. The highest cost of using the drug was candesartan 16 mg (Rp 4,381,531). The percentages of adherence to the use of antihypertensive drugs with the national formulary in pharmacy A, B, and C were 73.91%, 80%, and 68.42%, respectively. Conclusion: In general, the highest consumption of antihypertensive drugs in Back-Referral Program (PRB) pharmacies in the area of Kudus Regency, which is included in the DU segment 90%, was amlodipine, and the suitability of drugs with the National Formulary has not reached 100%. Referring to the results of the pattern of use of PRB drugs in this study, it is hoped that there will be better coordination between BPJS Kesehatan and pharmacies regarding the distribution and availability of PRB drugs. Keywords: ATC/DDD, DU 90%, hypertension, national formulary, PRB","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83940030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of antifungal bioactive compounds from an ethanolic extract of beluntas leaves (Pluchea indica) against Microsporum canis","authors":"Devi Safitri, M. Muhaimin, Nelson Nelson, I. L. Tarigan, L. Lizawati, M. Latief","doi":"10.20885/jif.vol19.iss1.art5","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art5","url":null,"abstract":"Background: Fungus prevalence in Indonesia is still relatively high. This happens because Indonesia has high temperatures and humidity. Beluntas (Pluchea indica) is a shrub native to Indonesia and widely distributed in most parts of the country. Pluchea indica is usually used by the community as a medicine for skin diseases. The bioactive content of P. indica leaves has potential as an antifungal agent. One of the fungi that is pathogenic to humans is Microsporum canis. Method: N-hexane, ethyl acetate, and ethanol served as the solvents for the graded maceration method of extraction over two 24-hour periods. Furthermore, using Vacuum Liquid Chromatography (VLC) and characterization with UV-Vis and FT-IR. Antifungal activity was performed by disc diffusion method. Results: Pluchea indica leaves have antifungal activity in the ethanol extract of 20.08 mm (very strong), the F5 fraction of 22.24 mm (very strong), and the F5 isolate of 6.3 mm (weak) at a concentration of 4%. Based on the UV-Vis and FT-IR data, the isolate had a wavelength of 267 nm with a functional group of -OH, C=C aromatic, C-H, and C-O. Conclusion: Isolate from the ethanol extract of Pluchea indica leaves has potential as an antifungal originating from the flavonoid group. Keywords: Pluchea indica, antifungal, Microsporum canis, isolation compound","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82214719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Study of Monascus sp. Pigment Derivatives as Anticardiovascular Candidate","authors":"D. Zain, Anna Yuliana","doi":"10.20885/jif.vol19.iss1.art1","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art1","url":null,"abstract":"Background: Cardiovascular disease is the leading cause of death in the world. The therapeutic activity of Monascus sp. pigment can act as an anticardiovascular agent. Research on Monascus sp. pigment is rapidly developing, including the discovery of new pigments, the methods used, and their identification. Currently, there are 57 dyestuff compounds that have been successfully isolated from Monascus molds. So, researchers conducted an in-silico study of Monascus sp. Objective: To determine whether it can have better interactions and activities as an anticardiovascular medicine candidate. Method: PAK1 is used as a receptor for anticardiovascular drugs. 57 test compounds were carried out for ligand preparation and application of Lipinski's rule of five by using MarvinSketch software, ADME prediction and toxicity testing using PreADMET, the docking process using Autodock tools, and visualization using Discovery Studio. Results: The results of the docking analysis are seen from the values of binding affinity consecutively. compound R3 (-8.74 kcal/mol), red shandong (-8.16 kcal/mol), and monaphilol (-8.14 kcal/mol) are lower than the comparison compound bisoprolol (-6.44 kcal/mol), which shows that the three compounds have better interactions than the comparison compounds. Conclusion: Derivative compounds from Monascus sp. Pigment are predicted to have better interactions and can be used as anticardiovascular medicine candidates. Keywords: Monascus sp., pigment, anticardiovascular, in silico, PAK1, ADME, and toxicity","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88599449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}