Aging Medicine最新文献_第7页

Trends in age-specific incidence, mortality, and DALYs of female breast cancer from 1990 to 2021 1990年至2021年女性乳腺癌的特定年龄发病率、死亡率和DALYs趋势。

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-25 DOI: 10.1002/agm2.12382

Subhadra Priyadarshini, Kunja Bihari Panda

Objectives

Breast cancer is a leading cause of morbidity and mortality among women worldwide. This study aims to analyze the trends in breast cancer incidence, mortality, and disability-adjusted life years (DALYs) across different age groups from 1990 to 2021, and to project the mortality rate for the next decade.

Methods

Global breast cancer data were analyzed, focusing on three distinct age groups: 15–49 years, 50–69 years, and 70+ years. Joinpoint regression analysis was used to identify periods of significant changes in cancer rate trends (joinpoints). Age-specific annual percent changes (APC) and average annual percent changes (AAPC) were calculated to identify trends over time. Additionally, an autoregressive integrated moving average (ARIMA) model was employed to forecast future mortality rates.

Results

The overall incidence of breast cancer increased significantly with an AAPC of 1.6% from 1990 to 2021. The highest increase was observed in the 15–49 years age group (AAPC: 1.3%), while the 70+ years age group showed the lowest increase (AAPC: 0.2%). Mortality rates exhibited a complex pattern, with a modest overall increase (AAPC: 0.8%), a slight increase in the 15–49 years age group (AAPC: 0.4%), and decreases in both 50 and 69 years (AAPC: −0.4%) and 70+ years age groups (AAPC: –0.3%). DALY rates increased slightly overall (AAPC: 0.7%), primarily driven by the 15–49 years age group (AAPC: 0.4%), while the older age groups showed a declining trend (AAPC: −0.4%).

Conclusion

Incidence rates are rising across all age groups, with the highest increase observed among younger women (15–49 years). In contrast, older age groups (50 + years) are experiencing improvements in mortality and DALYs. These findings underscore the need for targeted public health interventions, enhanced screening practices, and ongoing advancements in breast cancer treatment to address the evolving burden of this disease across different age groups.

目的：乳腺癌是全世界妇女发病和死亡的主要原因。本研究旨在分析1990年至2021年不同年龄组乳腺癌发病率、死亡率和残疾调整生命年（DALYs）的趋势，并预测未来十年的死亡率。方法：对全球乳腺癌数据进行分析，重点分析3个不同年龄组：15-49岁、50-69岁和70+岁。接合点回归分析用于确定癌症发病率趋势的显著变化时期（接合点）。计算特定年龄的年变化百分比（APC）和平均年变化百分比（AAPC），以确定随时间变化的趋势。此外，采用自回归综合移动平均（ARIMA）模型预测未来死亡率。结果：从1990年到2021年，乳腺癌的总发病率显著增加，AAPC为1.6%。15-49岁年龄组增幅最大（AAPC: 1.3%）， 70岁以上年龄组增幅最低（AAPC: 0.2%）。死亡率表现出复杂的模式，总体上略有上升（AAPC: 0.8%）， 15-49岁年龄组略有上升（AAPC: 0.4%）， 50岁和69岁年龄组（AAPC: -0.4%）和70岁以上年龄组（AAPC: -0.3%）均有所下降。总体而言，DALY率略有上升（AAPC: 0.7%），主要受15-49岁年龄组（AAPC: 0.4%）的推动，而年龄较大的年龄组则呈下降趋势（AAPC: -0.4%）。结论：所有年龄组的发病率都在上升，其中年轻女性（15-49岁）的发病率增幅最大。相比之下，年龄较大的年龄组（50岁以上）的死亡率和伤残调整生命年正在改善。这些发现强调，需要有针对性的公共卫生干预措施，加强筛查实践，并在乳腺癌治疗方面不断取得进展，以解决不同年龄组乳腺癌不断变化的负担。

{"title":"Trends in age-specific incidence, mortality, and DALYs of female breast cancer from 1990 to 2021","authors":"Subhadra Priyadarshini, Kunja Bihari Panda","doi":"10.1002/agm2.12382","DOIUrl":"10.1002/agm2.12382","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Breast cancer is a leading cause of morbidity and mortality among women worldwide. This study aims to analyze the trends in breast cancer incidence, mortality, and disability-adjusted life years (DALYs) across different age groups from 1990 to 2021, and to project the mortality rate for the next decade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Global breast cancer data were analyzed, focusing on three distinct age groups: 15–49 years, 50–69 years, and 70+ years. Joinpoint regression analysis was used to identify periods of significant changes in cancer rate trends (joinpoints). Age-specific annual percent changes (APC) and average annual percent changes (AAPC) were calculated to identify trends over time. Additionally, an autoregressive integrated moving average (ARIMA) model was employed to forecast future mortality rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall incidence of breast cancer increased significantly with an AAPC of 1.6% from 1990 to 2021. The highest increase was observed in the 15–49 years age group (AAPC: 1.3%), while the 70+ years age group showed the lowest increase (AAPC: 0.2%). Mortality rates exhibited a complex pattern, with a modest overall increase (AAPC: 0.8%), a slight increase in the 15–49 years age group (AAPC: 0.4%), and decreases in both 50 and 69 years (AAPC: −0.4%) and 70+ years age groups (AAPC: –0.3%). DALY rates increased slightly overall (AAPC: 0.7%), primarily driven by the 15–49 years age group (AAPC: 0.4%), while the older age groups showed a declining trend (AAPC: −0.4%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Incidence rates are rising across all age groups, with the highest increase observed among younger women (15–49 years). In contrast, older age groups (50 + years) are experiencing improvements in mortality and DALYs. These findings underscore the need for targeted public health interventions, enhanced screening practices, and ongoing advancements in breast cancer treatment to address the evolving burden of this disease across different age groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"770-780"},"PeriodicalIF":2.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single-center observational cohort study 评估血透患者死亡风险的合并症指数模型的预测准确性：一项综合单中心观察队列研究

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-24 DOI: 10.1002/agm2.12384

Yanna Yu, Fen Li, Zhan Wang, Zhibin Ni, Shu Zhang, Weihong Zhao, Xiaohua Pei

Objectives

Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices. However, their application in China has been limited, particularly among maintenance hemodialysis (MHD) patients. Therefore, the objective of this study was to evaluate the utility of comorbidity index models in predicting mortality risk among Chinese MHD patients.

Methodology

The MHD patients in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were taken as the subjects. Claims-based disease-specific refinements matching translation to ICD-10 and flexibility (CDMF-CCI) model and Liu model were selected as the candidate models for this verification research. Univariate and multivariate Cox regression calculations were used to analyze the independent predictive effect of the models on survival rate.

Results

Annually, nearly 500 patients undergo hemodialysis treatment. From January 2019 to June 2022, a total of 199 patients succumbed, with a mean age of 65.2 years. During these 4 years, the mortality rates were 13.04%, 9.68%, 11.69%, and 6.39%, respectively. The leading causes of death were sudden demise (82 patients, 41.2%), cardiovascular disease (48 patients, 24.1%), pulmonary infection (33 patients, 16.5%), and stroke (19 patients, 9.5%). When compared to individual indices, the CDMF-CCI model displayed more accurate and predictive results, with an HR of 1.190 (P = 0.037). Conversely, the Liu model failed to identify high-risk individuals.

Conclusion

The MHD patients face a significant risk of mortality. When compared to univariate parameters and the Liu model, the CDMF-CCI model exhibits superior predictive accuracy for mortality in MHD patients.

目的：与单一指标相比，共病预测模型已被证明可提供更全面和准确的死亡风险预测。然而，它们在中国的应用有限，特别是在维持性血液透析（MHD）患者中的应用。因此，本研究的目的是评估合并症指数模型在预测中国MHD患者死亡风险中的效用。方法：以广州中医药大学第一附属医院的MHD患者为研究对象。基于理赔的疾病特异性细化匹配翻译ICD-10和灵活性（CDMF-CCI）模型和Liu模型被选为本验证研究的候选模型。采用单因素和多因素Cox回归计算分析各模型对生存率的独立预测效果。结果：每年有近500例患者接受血液透析治疗。2019年1月至2022年6月，共有199例患者死亡，平均年龄65.2岁。4年间的死亡率分别为13.04%、9.68%、11.69%和6.39%。主要死亡原因为猝死（82例，41.2%）、心血管疾病（48例，24.1%）、肺部感染（33例，16.5%）和脑卒中（19例，9.5%）。与单项指标相比，CDMF-CCI模型显示出更准确的预测结果，HR为1.190 （P = 0.037）。相反，Liu模型未能识别出高风险个体。结论：MHD患者存在显著的死亡风险。与单变量参数和Liu模型相比，CDMF-CCI模型对MHD患者死亡率的预测准确性更高。

{"title":"Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single-center observational cohort study","authors":"Yanna Yu, Fen Li, Zhan Wang, Zhibin Ni, Shu Zhang, Weihong Zhao, Xiaohua Pei","doi":"10.1002/agm2.12384","DOIUrl":"10.1002/agm2.12384","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices. However, their application in China has been limited, particularly among maintenance hemodialysis (MHD) patients. Therefore, the objective of this study was to evaluate the utility of comorbidity index models in predicting mortality risk among Chinese MHD patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>The MHD patients in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were taken as the subjects. Claims-based disease-specific refinements matching translation to ICD-10 and flexibility (CDMF-CCI) model and Liu model were selected as the candidate models for this verification research. Univariate and multivariate Cox regression calculations were used to analyze the independent predictive effect of the models on survival rate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Annually, nearly 500 patients undergo hemodialysis treatment. From January 2019 to June 2022, a total of 199 patients succumbed, with a mean age of 65.2 years. During these 4 years, the mortality rates were 13.04%, 9.68%, 11.69%, and 6.39%, respectively. The leading causes of death were sudden demise (82 patients, 41.2%), cardiovascular disease (48 patients, 24.1%), pulmonary infection (33 patients, 16.5%), and stroke (19 patients, 9.5%). When compared to individual indices, the CDMF-CCI model displayed more accurate and predictive results, with an HR of 1.190 (<i>P</i> = 0.037). Conversely, the Liu model failed to identify high-risk individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The MHD patients face a significant risk of mortality. When compared to univariate parameters and the Liu model, the CDMF-CCI model exhibits superior predictive accuracy for mortality in MHD patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"737-743"},"PeriodicalIF":2.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10-year prospective cohort study 中国部分牙齿缺失的老年人使用假牙和认知能力下降速度较慢：一项10年前瞻性队列研究

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-23 DOI: 10.1002/agm2.12383

Xiang Qi, Zheng Zhu, Yaolin Pei, Bei Wu

Objective

Denture use has been shown to improve nutritional intake and diet quality in people with tooth loss. Despite evidence linking tooth loss and dementia, few studies have examined the association between denture use and cognitive decline. We investigated the relationship between denture use and cognitive decline among Chinese older adults with tooth loss.

Methods

We analyzed data from the Chinese Longitudinal Healthy Longevity Survey 2008–2018, including 27,708 community-dwelling dentate and edentulous (i.e., who have lost all natural teeth) older adults aged 65 and older. Cognitive function was assessed using the Mini-Mental State Examination from 2008 to 2018. Linear mixed-effect models were employed to assess the association of denture use with baseline cognitive function and rate of cognitive decline, adjusting for sociodemographic characteristics, health-related behavior, and health status. Subgroup analyses evaluated differences in associations among dentate participants with varying degrees of tooth loss (1–9, 10–19, 20–31).

Results

Compared to non-denture users, dentate participants who used dentures had better baseline cognitive function (β, 1.032; 95% CI, 0.813–1.251; p < 0.001) and a slower annual decline in cognitive function (β, 0.127; 95% CI, 0.047–0.206; p < 0.01). For edentulous participants, denture use was associated with higher baseline cognitive function (β, 3.063; 95% CI, 2.703–3.423; p < 0.001) but not with the rate of cognitive decline (β, 0.011; 95% CI, –0.082 to 0.105; p = 0.818). Results remained consistent across subgroups of dentate participants with various degrees of missing teeth.

Conclusions

Denture use may help protect against cognitive decline in older adults with partial tooth loss. This study highlights the potential importance of prosthodontic rehabilitation in preserving cognitive health. Further research is needed to establish a causal relationship between denture use and cognitive function.

目的：假牙的使用已被证明可以改善缺牙患者的营养摄入和饮食质量。尽管有证据表明牙齿脱落和痴呆有关，但很少有研究调查假牙使用和认知能力下降之间的关系。我们调查了中国老年人牙齿脱落患者使用义齿与认知能力下降的关系。方法：我们分析了2008-2018年中国纵向健康寿命调查的数据，包括27,708名65岁及以上的社区居住有牙和无牙（即失去所有天然牙齿）的老年人。2008年至2018年使用迷你精神状态检查评估认知功能。采用线性混合效应模型评估假牙使用与基线认知功能和认知衰退率的关系，并对社会人口统计学特征、健康相关行为和健康状况进行调整。亚组分析评估了不同程度牙齿缺失的有牙参与者之间的关联差异（1- 9,10 - 19,20 -31）。结果：与不使用义齿的受试者相比，使用义齿的受试者具有更好的基线认知功能(β, 1.032；95% ci, 0.813-1.251；P β, 0.127；95% ci, 0.047-0.206；P β, 3.063；95% ci, 2.703-3.423；P β, 0.011；95% CI, -0.082 ~ 0.105；p = 0.818)。结果在不同程度缺失牙齿的有牙参与者亚组中保持一致。结论：假牙的使用可能有助于防止老年人部分牙齿缺失的认知能力下降。这项研究强调了修复康复在保持认知健康方面的潜在重要性。假牙使用与认知功能之间的因果关系有待进一步研究。

{"title":"Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10-year prospective cohort study","authors":"Xiang Qi, Zheng Zhu, Yaolin Pei, Bei Wu","doi":"10.1002/agm2.12383","DOIUrl":"10.1002/agm2.12383","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Denture use has been shown to improve nutritional intake and diet quality in people with tooth loss. Despite evidence linking tooth loss and dementia, few studies have examined the association between denture use and cognitive decline. We investigated the relationship between denture use and cognitive decline among Chinese older adults with tooth loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from the Chinese Longitudinal Healthy Longevity Survey 2008–2018, including 27,708 community-dwelling dentate and edentulous (i.e., who have lost all natural teeth) older adults aged 65 and older. Cognitive function was assessed using the Mini-Mental State Examination from 2008 to 2018. Linear mixed-effect models were employed to assess the association of denture use with baseline cognitive function and rate of cognitive decline, adjusting for sociodemographic characteristics, health-related behavior, and health status. Subgroup analyses evaluated differences in associations among dentate participants with varying degrees of tooth loss (1–9, 10–19, 20–31).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to non-denture users, dentate participants who used dentures had better baseline cognitive function (<i>β</i>, 1.032; 95% CI, 0.813–1.251; <i>p</i> < 0.001) and a slower annual decline in cognitive function (<i>β</i>, 0.127; 95% CI, 0.047–0.206; <i>p</i> < 0.01). For edentulous participants, denture use was associated with higher baseline cognitive function (<i>β</i>, 3.063; 95% CI, 2.703–3.423; <i>p</i> < 0.001) but not with the rate of cognitive decline (<i>β</i>, 0.011; 95% CI, –0.082 to 0.105; <i>p</i> = 0.818). Results remained consistent across subgroups of dentate participants with various degrees of missing teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Denture use may help protect against cognitive decline in older adults with partial tooth loss. This study highlights the potential importance of prosthodontic rehabilitation in preserving cognitive health. Further research is needed to establish a causal relationship between denture use and cognitive function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"781-789"},"PeriodicalIF":2.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry 中国血管认知障碍的预测、预防和个性化项目（P3）：一项全国多中心前瞻性登记的研究设计和中期基线患者特征。

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-23 DOI: 10.1002/agm2.12377

Linlin Wang, Jiwei Jiang, Yanli Wang, Gaifen Liu, Wenyi Li, Qiwei Ren, Shirui Jiang, Min Zhao, Huiying Zhang, Tianlin Jiang, Shiyi Yang, Mei Cui, Qiang Dong, Jun Xu

Objectives

To outline the design of the P3 study and serve as a summary of the interim baseline patient characteristics.

Methods

P3 study is a multicenter, prospective cohort study targeting 1000 acute ischemic stroke (AIS) and cerebral small vessel disease (CSVD) patients with a 2-year follow-up from 80 participating hospitals across China. Comprehensive multimodal imaging, neuropsychological tests, and biological samples were collected prospectively on admission and follow-up visits. Patients were interviewed face to face for 2 years and followed up.

Results

Until 30 December 2023, 642 patients were enrolled from 67 centers. In the AIS cohort, 219 patients (72.5%) were diagnosed with acute post-stroke cognitive impairment (PSCI). Compared to those without PSCI, the acute PSCI group exhibited significantly lower levels of education and a history of stroke (all P < 0.05). In the CSVD cohort, 53 patients (41.4%) were diagnosed with cognitive impairment. Compared to those with normal cognitive function, the impaired cognitive function group had a significantly higher prevalence of hypertension and diabetes history (all P < 0.05). All 642 patients completed 20 tests, as well as clinical information and blood sample collection. Nearly 95% of the patients underwent structural MRI and ASL, and 60% of patients completed fMRI and DKI or DTI.

Conclusions

P3 study aims to establish a comprehensive spatiotemporal profile of VCI. Through multidimensional analysis of clinical information, radiomics, proteomics, metabolomics, microbiomics, and genetics, provide a more comprehensive understanding of VCI trajectories and individual variability, enhancing early detection and prognosis management.

目的：概述P3研究的设计，并作为中期基线患者特征的总结。P3研究是一项多中心、前瞻性队列研究，针对中国80家医院的1000例急性缺血性脑卒中（AIS）和脑血管病（CSVD）患者进行为期2年的随访。在入院和随访时前瞻性地收集综合多模态成像、神经心理测试和生物样本。对患者进行为期2年的面对面访谈和随访。结果：截至2023年12月30日，来自67个中心的642名患者入组。在AIS队列中，219例患者（72.5%）被诊断为急性脑卒中后认知障碍（PSCI）。与无PSCI组相比，急性PSCI组的受教育水平和卒中史显著降低（均为P P）。结论：P3研究旨在建立VCI的全面时空分布。通过临床信息、放射组学、蛋白质组学、代谢组学、微生物组学和遗传学的多维分析，更全面地了解VCI的发展轨迹和个体差异，加强早期发现和预后管理。

{"title":"Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry","authors":"Linlin Wang, Jiwei Jiang, Yanli Wang, Gaifen Liu, Wenyi Li, Qiwei Ren, Shirui Jiang, Min Zhao, Huiying Zhang, Tianlin Jiang, Shiyi Yang, Mei Cui, Qiang Dong, Jun Xu","doi":"10.1002/agm2.12377","DOIUrl":"10.1002/agm2.12377","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To outline the design of the P3 study and serve as a summary of the interim baseline patient characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>P3 study is a multicenter, prospective cohort study targeting 1000 acute ischemic stroke (AIS) and cerebral small vessel disease (CSVD) patients with a 2-year follow-up from 80 participating hospitals across China. Comprehensive multimodal imaging, neuropsychological tests, and biological samples were collected prospectively on admission and follow-up visits. Patients were interviewed face to face for 2 years and followed up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Until 30 December 2023, 642 patients were enrolled from 67 centers. In the AIS cohort, 219 patients (72.5%) were diagnosed with acute post-stroke cognitive impairment (PSCI). Compared to those without PSCI, the acute PSCI group exhibited significantly lower levels of education and a history of stroke (all <i>P</i> < 0.05). In the CSVD cohort, 53 patients (41.4%) were diagnosed with cognitive impairment. Compared to those with normal cognitive function, the impaired cognitive function group had a significantly higher prevalence of hypertension and diabetes history (all <i>P</i> < 0.05). All 642 patients completed 20 tests, as well as clinical information and blood sample collection. Nearly 95% of the patients underwent structural MRI and ASL, and 60% of patients completed fMRI and DKI or DTI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>P3 study aims to establish a comprehensive spatiotemporal profile of VCI. Through multidimensional analysis of clinical information, radiomics, proteomics, metabolomics, microbiomics, and genetics, provide a more comprehensive understanding of VCI trajectories and individual variability, enhancing early detection and prognosis management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"744-753"},"PeriodicalIF":2.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound blood–brain barrier opening: A new era of treatment for Alzheimer's disease? 超声血脑屏障打开：阿尔茨海默病治疗的新时代？

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-23 DOI: 10.1002/agm2.12371

Cuiping Wang, Junhong Ren

<p>The blood–brain barrier (BBB) plays an important role in maintaining the stability of the central nervous system (CNS). However, it serves as a formidable barrier that restricts the entry of therapeutic agents. Recent research shows that some pathways have the potential to reshape conventional drug delivery paradigms and address the limitations caused by the selectivity of the BBB. Innovative approaches to enhance drug delivery include intranasal delivery exploiting olfactory and trigeminal pathways, as well as techniques such as temporary BBB opening using chemicals and receptors, or focused ultrasound (FUS).<span><sup>1</sup></span> These technologies have their pros and cons. The intranasal delivery route is considered non-invasive, and drug transportation might proceed via the olfactory and trigeminal pathways, ultimately leading access to the CNS.<span><sup>2</sup></span> However, nasal administration exhibits certain limitations, such as the lack of consistency in the administered dosage of the drug.<span><sup>3</sup></span> Chemicals, such as borneol and alkyl glycerols, can enhance the permeability of the BBB, potentially revolutionizing drug delivery to the brain. However, consideration must be given to their potential toxicity and lack of selectivity. The second approach involves modifying tight junctions using adenosine receptor agonists, which has various advantages for drug administration across the BBB. Receptor-mediated modulation, owing to its inherent reversibility, has advantages of temporal regulation and adaptability during pharmaceutical administration.<span><sup>4</sup></span> The limitations of receptor-mediated tight junction transition include the absence of suitable receptors within the targeted region, the potential for unintended consequences for unrelated biological pathways or tissues, the inherent variability in receptor expression across the BBB, and the requirement for meticulous adherence to regulatory and safety protocols.<span><sup>5</sup></span> The third approach involves FUS to facilitate drug transport through the BBB. The application of FUS spans various domains, encompassing imaging, tumor ablation, neuromodulation, targeted gene therapy, and increasing drug delivery to the cerebral region.<span><sup>1</sup></span> Magnetic resonance imaging (MRI) guided FUS uses focused ultrasound energy, delivered transcranially, to treat a variety of neurological diseases, such as essential tremor (ET), Parkinson disease (PD), neuropathic pain, and dystonia.<span><sup>6, 7</sup></span> A variety of neuropathic pain syndromes have been successfully treated using MRI-guided FUS central lateral thalamotomy.<span><sup>6</sup></span> MRI-guided FUS ventralis intermedius (VIM) thalamotomy is now a well-established and federal drug administration (FDA) approved therapy in medication-refractory ET and for the motor symptoms of PD. The use of concurrent MRI allows highly accurate spatial and thermal guidance, with fine anato

血脑屏障（BBB）在维持中枢神经系统（CNS）的稳定性方面起着重要作用。然而，它是一个巨大的障碍，限制了治疗剂的进入。最近的研究表明，一些途径有可能重塑传统的药物传递模式，并解决血脑屏障选择性造成的限制。增强药物传递的创新方法包括利用嗅觉和三叉神经通路的鼻内给药，以及使用化学物质和受体或聚焦超声（FUS）等临时打开血脑屏障的技术这些技术有其优点和缺点。鼻内给药途径被认为是非侵入性的，药物运输可能通过嗅觉和三叉神经通路进行，最终进入中枢神经系统。2然而，鼻给药表现出一定的局限性，例如给药剂量缺乏一致性化学物质，如冰片和烷基甘油，可以增强血脑屏障的通透性，可能会彻底改变药物向大脑的输送。然而，必须考虑到它们的潜在毒性和缺乏选择性。第二种方法涉及使用腺苷受体激动剂修饰紧密连接，这对于跨血脑屏障给药具有各种优势。受体介导的调节由于其固有的可逆性，在给药过程中具有时间调节和适应性的优势受体介导的紧密连接转换的局限性包括：在目标区域缺乏合适的受体，对不相关的生物途径或组织可能产生意想不到的后果，血脑屏障中受体表达的固有变异性，以及严格遵守监管和安全协议的要求第三种方法涉及FUS促进药物通过血脑屏障的运输。FUS的应用跨越多个领域，包括成像、肿瘤消融、神经调节、靶向基因治疗和增加大脑区域的药物输送磁共振成像（MRI）引导的FUS利用聚焦的超声能量，经颅传递，治疗多种神经系统疾病，如特发性震颤（ET）、帕金森病（PD）、神经性疼痛和肌张力障碍。使用mri引导下的FUS中央外侧丘脑切开术已经成功治疗了多种神经性疼痛综合征mri引导下的FUS腹正中肌（VIM）丘脑切开术目前是一种完善的、联邦药物管理局（FDA）批准的治疗难治性ET和帕金森病运动症状的方法。同时使用MRI可以实现高度精确的空间和热引导，具有精细的解剖细节，高软组织对比度，以及对治疗区域的实时监测。mri引导的FUS，暂时靶向血脑屏障，可以在焦点处诱导可控的热升高，实现血脑屏障的短暂，局部和可逆的破坏，从而帮助靶向治疗或神经免疫调节的传递。该技术具有精度高、利用非电离辐射和实时监测目标地点温度的能力等优点。然而，其潜在的风险和安全措施仍然需要考虑。阿尔茨海默病（AD）是最常见的中枢神经系统退行性疾病之一。目前，全球约有4600万人患有阿尔茨海默病，预计到2050年，这一数字将增加两倍，对卫生保健构成巨大挑战目前公认的AD的病理机制是淀粉样蛋白级联理论，其特征是淀粉样蛋白- β (Aβ)蛋白的积累导致神经元内老年斑和神经原纤维缠结。最近，抗a β的单克隆抗体，包括aducanumab、lecanemab和donenemab，已被证明对AD有效。在2024年1月4日出版的《新英格兰医学杂志》上，Rezai等人报道了一项涉及三名轻度AD患者的概念验证试验，该试验评估了aducanumab输注与mri引导的FUS联合穿透血脑卒中并靶向AD中a β的安全性和可行性。该试验涉及三个参与者的大脑一侧的小组织体积。方案治疗分为两个阶段：干预阶段，在aducanumab治疗时联合FUS打开血脑屏障，为期6个月；随访阶段，参与者单独接受aducanumab输注，为期5年。该研究显示，在正电子发射断层扫描（PET）中使用氟-18 florbetaben量化的a β水平适度下降，并且在6个月的联合治疗期间没有认知恶化。在三名参与者中，在联合治疗阶段，与另一侧相同的未治疗的大脑区域相比，FUS靶向区域的a β水平下降更为显著（从48%到63%不等）。早期研究表明，单独应用FUS可略微降低Aβ水平。实验模型表明，与未使用FUS治疗的脑区相比，使用FUS导致aducanumab对目标脑区的递送量增加了5至8倍。然而，Rezai等人证实，在随访阶段，两名参与者没有经历神经学、认知或行为改变。只有一名参与者表现出认知能力下降；然而，在他们的神经状态或日常生活活动中没有发现任何改变。很难确定这些认知变化是否与疾病或手术有关，主要是因为参与者人数少。这需要进一步的临床研究来证实。关于不良反应，Rezai等人注意到头痛是最常见的副作用，但通常是轻微的，有一例中度头痛。治疗与梗死、水肿、脱髓鞘、出血或胶质瘤无关。在另一项1期试验中，5名AD患者接受mri引导下的FUS打开血脑屏障。使用不到消融所需能量的1%，沿额叶白质的血脑屏障被成功确认，并通过局部钆外渗增强靶区，这被证明是可重复的，没有严重的不良反应另一项研究旨在通过对2014年至2023年涉及258例患者的20项研究进行系统回顾和荟萃分析，评估mri引导下的FUS治疗PD的疗效和安全性，结果表明mri引导下的FUS为耐药PD相关震颤患者提供了一种有效且相对安全的治疗选择14因此，mri引导下的FUS可以安全、可逆地破坏血脑屏障，而不会引起严重的不良事件。使用FUS打开血脑屏障以允许药物递送治疗AD的策略已在临床前环境中广泛实施，其临床应用正在探索早期AD。尽管取得了这些进展，但在完善其应用方面仍有许多工作要做。首先，加强临床试验对于优化药物剂量、FUS会话的频率和范围以及靶脑区域的选择至关重要。此外，虽然FUS技术不断发展，但它主要与昂贵的MRI系统集成，限制了其更广泛的临床应用。这一限制促使人们追求更简单、更快、更安全、更经济的替代方案。值得注意的是，便携式、神经导航引导的FUS系统的出现提供了一种更便宜、更有效的选择，有可能扩大FUS在不同护理点对AD和其他神经系统疾病的可及性此外，虽然单独靶向Aβ并不能逆转疾病，但FUS，类似于阿尔茨海默病的药物治疗方法，在晚期不能完全逆转疾病。尽管如此，在阿尔茨海默病的早期干预中使用FUS，特别是在无症状或初始阶段，可能会推迟疾病的进展晚期治疗的有限有效性与早期干预的令人鼓舞的结果相比较，值得对FUS在症状前阿尔茨海默病阶段的预防能力进行更深入的探索。综上所述，现有的研究支持FUS在治疗AD中的可能作用。未来的研究需要确定使用FUS延缓AD认知和病理影响的安全性和可行性。随着该领域的进展，我们相信FUS将为阿尔茨海默病治疗提供创新的方向和见解。论文起草：C.W.对重要知识内容的关键性修改：J.R.。行政、技术或物质支持：J.R.。研究监督：J.R.。本研究获得国家高水平医院临床研究经费（BJ-2023-096, BJ-2018-198），北京市科学与技术基金；技术委员会（Z211100002921011）。作者没有需要披露的利益冲突。

{"title":"Ultrasound blood–brain barrier opening: A new era of treatment for Alzheimer's disease?","authors":"Cuiping Wang, Junhong Ren","doi":"10.1002/agm2.12371","DOIUrl":"10.1002/agm2.12371","url":null,"abstract":"<p>The blood–brain barrier (BBB) plays an important role in maintaining the stability of the central nervous system (CNS). However, it serves as a formidable barrier that restricts the entry of therapeutic agents. Recent research shows that some pathways have the potential to reshape conventional drug delivery paradigms and address the limitations caused by the selectivity of the BBB. Innovative approaches to enhance drug delivery include intranasal delivery exploiting olfactory and trigeminal pathways, as well as techniques such as temporary BBB opening using chemicals and receptors, or focused ultrasound (FUS).<span><sup>1</sup></span> These technologies have their pros and cons. The intranasal delivery route is considered non-invasive, and drug transportation might proceed via the olfactory and trigeminal pathways, ultimately leading access to the CNS.<span><sup>2</sup></span> However, nasal administration exhibits certain limitations, such as the lack of consistency in the administered dosage of the drug.<span><sup>3</sup></span> Chemicals, such as borneol and alkyl glycerols, can enhance the permeability of the BBB, potentially revolutionizing drug delivery to the brain. However, consideration must be given to their potential toxicity and lack of selectivity. The second approach involves modifying tight junctions using adenosine receptor agonists, which has various advantages for drug administration across the BBB. Receptor-mediated modulation, owing to its inherent reversibility, has advantages of temporal regulation and adaptability during pharmaceutical administration.<span><sup>4</sup></span> The limitations of receptor-mediated tight junction transition include the absence of suitable receptors within the targeted region, the potential for unintended consequences for unrelated biological pathways or tissues, the inherent variability in receptor expression across the BBB, and the requirement for meticulous adherence to regulatory and safety protocols.<span><sup>5</sup></span> The third approach involves FUS to facilitate drug transport through the BBB. The application of FUS spans various domains, encompassing imaging, tumor ablation, neuromodulation, targeted gene therapy, and increasing drug delivery to the cerebral region.<span><sup>1</sup></span> Magnetic resonance imaging (MRI) guided FUS uses focused ultrasound energy, delivered transcranially, to treat a variety of neurological diseases, such as essential tremor (ET), Parkinson disease (PD), neuropathic pain, and dystonia.<span><sup>6, 7</sup></span> A variety of neuropathic pain syndromes have been successfully treated using MRI-guided FUS central lateral thalamotomy.<span><sup>6</sup></span> MRI-guided FUS ventralis intermedius (VIM) thalamotomy is now a well-established and federal drug administration (FDA) approved therapy in medication-refractory ET and for the motor symptoms of PD. The use of concurrent MRI allows highly accurate spatial and thermal guidance, with fine anato","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"673-675"},"PeriodicalIF":2.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel hormonal agents in men with metastatic castration resistant prostate cancer and reduced performance status: Experiences of a specialized single center 新型激素治疗转移性去势抵抗性前列腺癌患者并降低工作表现：一个专门的单一中心的经验。

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-19 DOI: 10.1002/agm2.12372

Thomas Büttner, Philipp Lossin, Stefan Latz, Carolin Jacobs, Philipp Krausewitz, Stefan Hauser

Objectives

Attaining castration resistance in metastatic prostate cancer (mCRPC) represents a pivotal juncture in the progression of the patient's illness and treatment regimen. Within this therapeutic context, novel hormonal agents (NHA) constitute a fundamental component of pharmacological intervention. However, the efficacy of NHA therapy remains uncertain for patients with a compromised general condition, as indicated by an Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of ≥2. Notably, most clinical trials excluded individuals with an ECOG PS ≥2, leaving a gap in our understanding of the potential benefits of NHA therapy for this specific patient cohort.

Methods

We conducted an analysis of fifty-three NHA-naïve men characterized by attaining mCRPC at an ECOG PS of ≥2 subsequent to androgen deprivation monotherapy between 2008 and 2023. Patients were then treated with either NHA or Best Supportive Care (BSC) based on individual decisions. Survival and adverse event (AE) analysis was performed to assess the outcomes of NHA therapy compared to BSC.

Results

Among the patients, 30 (56.6%) received NHA, whereas the remaining 23 (43.4%) choose BSC. No significant differences in baseline characteristics were observed between the NHA and BSC group. Median overall survival (OS) was 9.1 months in the BSC group and 7.0 months in the NHA group, with no significant OS benefits associated with NHA treatment. AEs and severe AEs commonly occurred, but remained indifferent between treatment groups.

Conclusions

Our findings suggest that NHA therapy may confer reduced survival benefits in mCRPC patients with ECOG PS ≥2. While hope for NHA treatment persists, particularly given its oral administration and tolerability, careful consideration and discussion with patients regarding treatment expectations and palliative care goals are warranted in this challenging patient population.

目的：在转移性前列腺癌（mCRPC）中获得去势抵抗是患者疾病进展和治疗方案的关键节点。在这种治疗背景下，新型激素制剂（NHA）构成了药理学干预的基本组成部分。然而，根据东部肿瘤合作组表现状态（ECOG PS）评分≥2分，NHA治疗对一般情况受损患者的疗效仍不确定。值得注意的是，大多数临床试验排除了ECOG PS≥2的个体，这使得我们对NHA治疗对这一特定患者群体的潜在益处的理解存在空白。方法：我们对53名NHA-naïve男性进行了分析，这些男性在2008年至2023年间接受雄激素剥夺单药治疗后，ECOG PS≥2时达到mCRPC。然后患者根据个人决定接受NHA或最佳支持治疗（BSC）。进行生存和不良事件（AE）分析，以评估NHA治疗与BSC治疗的结果。结果：30例（56.6%）患者接受NHA治疗，23例（43.4%）患者选择BSC治疗。NHA组和BSC组的基线特征无显著差异。BSC组的中位总生存期（OS）为9.1个月，NHA组的中位总生存期（OS）为7.0个月，NHA治疗没有显著的OS获益。不良反应（ae）和严重不良反应（ae）普遍发生，但在治疗组之间没有差异。结论：我们的研究结果表明，对于ECOG PS≥2的mCRPC患者，NHA治疗可能会降低生存获益。虽然NHA治疗的希望仍然存在，特别是考虑到其口服给药和耐受性，但在这一具有挑战性的患者群体中，需要仔细考虑和与患者讨论治疗期望和姑息治疗目标。

{"title":"Novel hormonal agents in men with metastatic castration resistant prostate cancer and reduced performance status: Experiences of a specialized single center","authors":"Thomas Büttner, Philipp Lossin, Stefan Latz, Carolin Jacobs, Philipp Krausewitz, Stefan Hauser","doi":"10.1002/agm2.12372","DOIUrl":"10.1002/agm2.12372","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Attaining castration resistance in metastatic prostate cancer (mCRPC) represents a pivotal juncture in the progression of the patient's illness and treatment regimen. Within this therapeutic context, novel hormonal agents (NHA) constitute a fundamental component of pharmacological intervention. However, the efficacy of NHA therapy remains uncertain for patients with a compromised general condition, as indicated by an Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of ≥2. Notably, most clinical trials excluded individuals with an ECOG PS ≥2, leaving a gap in our understanding of the potential benefits of NHA therapy for this specific patient cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted an analysis of fifty-three NHA-naïve men characterized by attaining mCRPC at an ECOG PS of ≥2 subsequent to androgen deprivation monotherapy between 2008 and 2023. Patients were then treated with either NHA or Best Supportive Care (BSC) based on individual decisions. Survival and adverse event (AE) analysis was performed to assess the outcomes of NHA therapy compared to BSC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the patients, 30 (56.6%) received NHA, whereas the remaining 23 (43.4%) choose BSC. No significant differences in baseline characteristics were observed between the NHA and BSC group. Median overall survival (OS) was 9.1 months in the BSC group and 7.0 months in the NHA group, with no significant OS benefits associated with NHA treatment. AEs and severe AEs commonly occurred, but remained indifferent between treatment groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that NHA therapy may confer reduced survival benefits in mCRPC patients with ECOG PS ≥2. While hope for NHA treatment persists, particularly given its oral administration and tolerability, careful consideration and discussion with patients regarding treatment expectations and palliative care goals are warranted in this challenging patient population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"761-769"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with hypercholesterolemia in older adults: A cross-sectional investigation 与老年人高胆固醇血症相关的因素：横断面调查。

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-19 DOI: 10.1002/agm2.12373

Maria Clara Alves de Oliveira, Júlia Perfeito Andrade, Ana Carolina Souza Porto, Gizelly Maria Torres Martins, Nurielly Monteiro Campos, Paulo da Fonseca Valença Neto, Claudio Bispo De Almeida, Saulo Sacramento Meira, Beatriz Cardoso Roriz, Débora Jesus da Silva, Victor Giovannino Accetta, Cezar Augusto Casotti, Lucas dos Santos

Objective

To investigate the factors associated with hypercholesterolemia in older adults residing in a small municipality in northeastern Brazil.

Methods

This is a population-based cross-sectional epidemiological study conducted with 232 older adults (women: 58.60%; men: 41.40%) in Aiquara, Bahia, Brazil. Independent variables included socioeconomic, behavioral, and health-related factors. The outcome was self-reported hypercholesterolemia (yes or no). Poisson regression with a robust estimator was used to calculate Prevalence Ratios (PR) and their respective 95% Confidence Intervals (CI) in the inferential analysis. Gross models were initially developed, followed by a hierarchical multiple explanatory model (Level 1: socioeconomic variables; Level 2: behavioral aspects; Level 3: health conditions).

Results

The observed prevalence of hypercholesterolemia was 34.50% (men: 21.90%; women: 43.40%). Additionally, a higher probability of hypercholesterolemia was observed in women (PR: 1.94; 95% CI: 1.27–2.97); participants with high sedentary behavior (PR: 1.47; 95% CI: 1.03–2.09); those with abdominal obesity (PR: 1.65; 95% CI: 1.06–2.57); and those with diabetes mellitus (PR: 1.54; 95% CI: 1.04–2.29).

Conclusion

The main results showed that female sex, high sedentary behavior, abdominal obesity, and diabetes mellitus were positively associated with hypercholesterolemia in the older population of the study.

目的：调查巴西东北部一个小城市老年人高胆固醇血症的相关因素。方法：这是一项基于人群的横断面流行病学研究，对232名老年人(女性：58.60%；男性：41.40%)，来自巴西巴伊亚州的Aiquara。独立变量包括社会经济、行为和健康相关因素。结果是自我报告的高胆固醇血症（是或否）。在推理分析中，使用稳健估计的泊松回归计算患病率比（PR）及其各自的95%置信区间（CI）。首先开发了Gross模型，然后是分层多重解释模型(第一级：社会经济变量；第二层：行为方面；第3级：健康状况)。结果：观察到的高胆固醇血症患病率为34.50%(男性：21.90%；女性:43.40%)。此外，在女性中观察到高胆固醇血症的可能性更高(PR: 1.94；95% ci: 1.27-2.97)；久坐行为高的参与者(PR: 1.47；95% ci: 1.03-2.09)；腹部肥胖组(PR: 1.65；95% ci: 1.06-2.57)；糖尿病患者(PR: 1.54；95% ci: 1.04-2.29)。结论：主要结果显示，女性、久坐行为、腹部肥胖、糖尿病与研究对象中老年人群的高胆固醇血症呈正相关。

{"title":"Factors associated with hypercholesterolemia in older adults: A cross-sectional investigation","authors":"Maria Clara Alves de Oliveira, Júlia Perfeito Andrade, Ana Carolina Souza Porto, Gizelly Maria Torres Martins, Nurielly Monteiro Campos, Paulo da Fonseca Valença Neto, Claudio Bispo De Almeida, Saulo Sacramento Meira, Beatriz Cardoso Roriz, Débora Jesus da Silva, Victor Giovannino Accetta, Cezar Augusto Casotti, Lucas dos Santos","doi":"10.1002/agm2.12373","DOIUrl":"10.1002/agm2.12373","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the factors associated with hypercholesterolemia in older adults residing in a small municipality in northeastern Brazil.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a population-based cross-sectional epidemiological study conducted with 232 older adults (women: 58.60%; men: 41.40%) in Aiquara, Bahia, Brazil. Independent variables included socioeconomic, behavioral, and health-related factors. The outcome was self-reported hypercholesterolemia (yes or no). Poisson regression with a robust estimator was used to calculate Prevalence Ratios (PR) and their respective 95% Confidence Intervals (CI) in the inferential analysis. Gross models were initially developed, followed by a hierarchical multiple explanatory model (Level 1: socioeconomic variables; Level 2: behavioral aspects; Level 3: health conditions).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The observed prevalence of hypercholesterolemia was 34.50% (men: 21.90%; women: 43.40%). Additionally, a higher probability of hypercholesterolemia was observed in women (PR: 1.94; 95% CI: 1.27–2.97); participants with high sedentary behavior (PR: 1.47; 95% CI: 1.03–2.09); those with abdominal obesity (PR: 1.65; 95% CI: 1.06–2.57); and those with diabetes mellitus (PR: 1.54; 95% CI: 1.04–2.29).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The main results showed that female sex, high sedentary behavior, abdominal obesity, and diabetes mellitus were positively associated with hypercholesterolemia in the older population of the study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"727-736"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triglyceride-glucose index trajectories predict adverse cardiovascular outcomes in elderly heart failure patients with Diabetes: A retrospective cohort study 甘油三酯-葡萄糖指数轨迹预测老年心力衰竭合并糖尿病患者的不良心血管结局：一项回顾性队列研究

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-19 DOI: 10.1002/agm2.12374

Hong Liu, Jian Wang, Zhi Luo, Ding Jia, Shixing Feng, Zhufang Yang, Zeyu Wang

Objective

Evaluating the change trajectories of triglyceride-glucose (TyG) index calculated after multiple tests in elderly heart failure (HF) patients may have clinical implications for predicting long-term adverse cardiovascular events (MACEs).

Methods

This retrospective study included 1184 elderly HF (LVEF ≥50%) patients with diabetes admitted to our center between January 2015 and January 2020. Based on the multiple TyG levels detected during the exposure period with annual measurements, three distinct TyG trajectories were determined using latent mixture modeling: low-stable group (TyG index <8.26, n = 367), medium-stable group (TyG index 8.26–9.06, n = 613), and high-increasing group (TyG index >9.06, n = 204). The primary endpoint was the composite outcome of MACEs.

Results

There were significant increases in the prevalence of several cardiovascular risk factors and conditions, such as male gender, BMI, current smoker, hyperlipidemia, atrial fibrillation, old myocardial infarction, fasting glucose, triglycerides, and uric acid levels, from the Low-Stable Group to the High-Increasing Group (all P < 0.05). During a median follow-up of 29 months (range, 18–46 months), 181 MACEs occurred. Kaplan–Meier analyses curve showed a significantly increased risk of MACEs in the medium-stable and high-increasing groups compared to the low-stable group (HR = 2.528, 95%CI: 1.665–3.838; HR = 2.706, 95%CI: 1.722–4.255, respectively). Furthermore, the rates of heart failure-related hospitalizations, nonfatal myocardial infarctions and non-fatal stroke were significantly increased in the medium-stable and high-increasing groups. Multivariable Cox regression analyses revealed that age (HR = 1.728), current smoker (HR = 1.385), old myocardial infarction (HR = 1.593), chronic renal disease (HR = 1.682), HbA1c (HR = 1.816), NT-proBNP (HR = 2.471), TyG trajectory (HR = 2.112) and SGLT2 inhibitors (HR = 0.841) were independently associated with the occurrence of MACEs during follow-up (P < 0.05).

Conclusions

The TyG trajectory is strongly associated with the risk of MACEs during follow-up in elderly patients with T2DM, suggesting that TyG trajectories may further optimize risk stratification model of cardiovascular events.

目的：评估老年心力衰竭（HF）患者多次检测后计算的甘油三酯-葡萄糖（TyG）指数的变化轨迹，可能对预测长期不良心血管事件（mace）具有临床意义。方法：本回顾性研究纳入2015年1月至2020年1月在本中心就诊的1184例老年HF （LVEF≥50%）合并糖尿病患者。根据每年监测的暴露期多种TyG水平，利用潜在混合模型确定了3种不同的TyG轨迹：低稳定组（TyG指数n = 367）、中稳定组（TyG指数8.26 ~ 9.06,n = 613）和高增长组（TyG指数>9.06,n = 204）。主要终点为mace的综合结局。结果：从低稳定组到高稳定组，男性、BMI、吸烟、高脂血症、房颤、陈旧性心肌梗死、空腹血糖、甘油三酯和尿酸水平等心血管危险因素和条件的患病率显著增加(所有P HR = 2.528, 95%CI: 1.665-3.838；HR = 2.706, 95%CI: 1.722-4.255)。此外，心力衰竭相关的住院率、非致死性心肌梗死和非致死性卒中的发生率在中度稳定和高增长组中显著增加。多变量Cox回归分析显示，年龄（HR = 1.728）、吸烟（HR = 1.385）、陈旧性心肌梗死（HR = 1.593）、慢性肾病（HR = 1.682）、HbA1c （HR = 1.816）、NT-proBNP （HR = 2.471）、TyG轨迹（HR = 2.112）和SGLT2抑制剂（HR = 0.841）与随访期间mace的发生独立相关(P)。在老年T2DM患者随访期间，TyG轨迹与mace风险密切相关，提示TyG轨迹可以进一步优化心血管事件的风险分层模型。

{"title":"Triglyceride-glucose index trajectories predict adverse cardiovascular outcomes in elderly heart failure patients with Diabetes: A retrospective cohort study","authors":"Hong Liu, Jian Wang, Zhi Luo, Ding Jia, Shixing Feng, Zhufang Yang, Zeyu Wang","doi":"10.1002/agm2.12374","DOIUrl":"10.1002/agm2.12374","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Evaluating the change trajectories of triglyceride-glucose (TyG) index calculated after multiple tests in elderly heart failure (HF) patients may have clinical implications for predicting long-term adverse cardiovascular events (MACEs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 1184 elderly HF (LVEF ≥50%) patients with diabetes admitted to our center between January 2015 and January 2020. Based on the multiple TyG levels detected during the exposure period with annual measurements, three distinct TyG trajectories were determined using latent mixture modeling: low-stable group (TyG index <8.26, <i>n</i> = 367), medium-stable group (TyG index 8.26–9.06, <i>n</i> = 613), and high-increasing group (TyG index >9.06, <i>n</i> = 204). The primary endpoint was the composite outcome of MACEs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were significant increases in the prevalence of several cardiovascular risk factors and conditions, such as male gender, BMI, current smoker, hyperlipidemia, atrial fibrillation, old myocardial infarction, fasting glucose, triglycerides, and uric acid levels, from the Low-Stable Group to the High-Increasing Group (all <i>P</i> < 0.05). During a median follow-up of 29 months (range, 18–46 months), 181 MACEs occurred. Kaplan–Meier analyses curve showed a significantly increased risk of MACEs in the medium-stable and high-increasing groups compared to the low-stable group (<i>HR</i> = 2.528, 95%<i>CI</i>: 1.665–3.838; <i>HR</i> = 2.706, 95%<i>CI</i>: 1.722–4.255, respectively). Furthermore, the rates of heart failure-related hospitalizations, nonfatal myocardial infarctions and non-fatal stroke were significantly increased in the medium-stable and high-increasing groups. Multivariable Cox regression analyses revealed that age (<i>HR</i> = 1.728), current smoker (<i>HR</i> = 1.385), old myocardial infarction (<i>HR</i> = 1.593), chronic renal disease (<i>HR</i> = 1.682), HbA1c (<i>HR</i> = 1.816), NT-proBNP (<i>HR</i> = 2.471), TyG trajectory (<i>HR</i> = 2.112) and SGLT2 inhibitors (<i>HR</i> = 0.841) were independently associated with the occurrence of MACEs during follow-up (<i>P</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The TyG trajectory is strongly associated with the risk of MACEs during follow-up in elderly patients with T2DM, suggesting that TyG trajectories may further optimize risk stratification model of cardiovascular events.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"717-726"},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of arthritis with functional disability and depressive symptoms in general US adults: NHANES 1988–1994 and 1999–2018 美国普通成年人关节炎与功能性残疾和抑郁症状的关联：NHANES 1988-1994和1999-2018

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-15 DOI: 10.1002/agm2.12379

Xiaoting Liu, Yunzhen Huang, Jinjing Fu, Mayila Mohedaner, Danzengzhuoga, Gan Yang, Zhenqing Yang, Xueqin Li, Xinye Ma, Qiqi Zhang, Zuyun Liu, Xifeng Wu, Zhimin Ying

Objectives

This study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed by X-ray examination) and functional disability. Above findings seek to highlight the need for comprehensive physical and mental health management in individuals with arthritis.

Methods

We designed a cross-sectional study utilizing multivariable logistic regression models to examine the associations. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were documented in a crude model and three adjusted models. Participants were from the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 1999–2018. Arthritis was self-reported or graded by the Kellgren–Lawrence score after an objective X-ray examination. Functional disability included disability in activities of daily living (ADL disability), instrumental activities of daily living (IADL disability), and mobility disability. Depressive symptom was assessed using the Patient Health Questionnaire (PHQ).

Results

We included 22,566 older adults (≥60 years; 10,961 had self-reported arthritis) for functional disability analysis (2377 older adults with data on X-ray examination; 1012 had radiographic knee osteoarthritis) and 32,056 adults (≥20 years; 9175 had self-reported arthritis) for depressive symptom analysis. After controlling for all covariates, self-reported arthritis was associated with ADL disability (odds ratios [OR]: 2.677; 95% confidence interval [CI]: 2.499–2.868), IADL disability (OR: 2.064; 95% CI: 1.940–2.196), and mobility disability (OR: 2.954; 95% CI: 2.778–3.142), and depressive symptom (OR: 2.177; 95% CI: 1.979–2.395). In participants with data on X-ray examination, radiographic knee osteoarthritis was only associated with mobility disability (OR: 1.437; 95% CI: 1.183–1.744).

Conclusions

Self-reported arthritis was associated with ADL disability, IADL disability and mobility disability, and depressive symptoms. Among participants with X-ray data, radiographic knee osteoarthritis was only associated with mobility disability in general US adults. Appropriate managements of both physical and mental health are needed for individuals with arthritis.

目的：本研究旨在研究美国普通成年人中关节炎与功能性残疾和抑郁症状的关系。此外，它探讨了膝关节骨关节炎（通过x线检查评估）与功能残疾之间的关系。上述研究结果旨在强调对关节炎患者进行全面身心健康管理的必要性。方法：我们设计了一项横断面研究，利用多变量逻辑回归模型来检验相关性。在一个粗模型和三个调整模型中记录了优势比（OR）和相应的95%置信区间（CI）。参与者来自1988-1994年和1999-2018年的国家健康与营养检查调查（NHANES）。在客观x线检查后，自行报告关节炎或根据kelgren - lawrence评分进行分级。功能性残疾包括日常生活活动障碍（ADL）、日常生活工具活动障碍（IADL）和行动障碍。使用患者健康问卷（PHQ）评估抑郁症状。结果：我们纳入了22,566名老年人(≥60岁；10,961人自我报告患有关节炎)进行功能残疾分析(2377名老年人有x线检查数据；1012例膝关节骨性关节炎)和32,056例成人(≥20岁；9175例自报关节炎)进行抑郁症状分析。在控制了所有协变量后，自我报告的关节炎与ADL残疾相关(优势比[OR]: 2.677；95%可信区间[CI]: 2.499-2.868)， IADL残疾(OR: 2.064；95% CI: 1.940-2.196)和行动障碍(OR: 2.954；95% CI: 2.778-3.142)和抑郁症状(OR: 2.177；95% ci: 1.979-2.395)。在有x线检查数据的参与者中，膝骨关节炎仅与活动障碍相关(OR: 1.437；95% ci: 1.183-1.744)。结论：自述关节炎与ADL残疾、IADL残疾和活动障碍以及抑郁症状相关。在有x线资料的参与者中，膝骨关节炎仅与一般美国成年人的行动障碍有关。关节炎患者需要适当的生理和心理健康管理。

{"title":"Associations of arthritis with functional disability and depressive symptoms in general US adults: NHANES 1988–1994 and 1999–2018","authors":"Xiaoting Liu, Yunzhen Huang, Jinjing Fu, Mayila Mohedaner,  Danzengzhuoga, Gan Yang, Zhenqing Yang, Xueqin Li, Xinye Ma, Qiqi Zhang, Zuyun Liu, Xifeng Wu, Zhimin Ying","doi":"10.1002/agm2.12379","DOIUrl":"10.1002/agm2.12379","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed by X-ray examination) and functional disability. Above findings seek to highlight the need for comprehensive physical and mental health management in individuals with arthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We designed a cross-sectional study utilizing multivariable logistic regression models to examine the associations. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were documented in a crude model and three adjusted models. Participants were from the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 1999–2018. Arthritis was self-reported or graded by the Kellgren–Lawrence score after an objective X-ray examination. Functional disability included disability in activities of daily living (ADL disability), instrumental activities of daily living (IADL disability), and mobility disability. Depressive symptom was assessed using the Patient Health Questionnaire (PHQ).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 22,566 older adults (≥60 years; 10,961 had self-reported arthritis) for functional disability analysis (2377 older adults with data on X-ray examination; 1012 had radiographic knee osteoarthritis) and 32,056 adults (≥20 years; 9175 had self-reported arthritis) for depressive symptom analysis. After controlling for all covariates, self-reported arthritis was associated with ADL disability (odds ratios [OR]: 2.677; 95% confidence interval [CI]: 2.499–2.868), IADL disability (OR: 2.064; 95% CI: 1.940–2.196), and mobility disability (OR: 2.954; 95% CI: 2.778–3.142), and depressive symptom (OR: 2.177; 95% CI: 1.979–2.395). In participants with data on X-ray examination, radiographic knee osteoarthritis was only associated with mobility disability (OR: 1.437; 95% CI: 1.183–1.744).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Self-reported arthritis was associated with ADL disability, IADL disability and mobility disability, and depressive symptoms. Among participants with X-ray data, radiographic knee osteoarthritis was only associated with mobility disability in general US adults. Appropriate managements of both physical and mental health are needed for individuals with arthritis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"705-716"},"PeriodicalIF":2.2,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Family support and dementia screening participation among older adults: Evidence from a South Korea fact-finding survey on the status of older adults 家庭支持和老年人痴呆筛查参与：来自韩国老年人状况实况调查的证据。

IF 2.2 Q3 GERIATRICS & GERONTOLOGY

Aging Medicine

Pub Date : 2024-12-13 DOI: 10.1002/agm2.12380

Jieun Kim, Hooyeon Lee

Objectives

South Korea is one of the most rapidly aging societies worldwide and the prevalence of dementia is expected to rise to 10.3% by 2025. Early diagnosis requires early access to support, information, and medication. Dementia screening is important for the success of dementia-related healthcare programs. We investigated the rate of participation in dementia screening and the relationship with family support.

Methods

We used data from the 2020 “South Korea fact-finding survey on status of older adults,” a cross-sectional survey targeting adults aged ≥65 years. A total of 9558 respondents were analyzed. We used multivariable logistic regression to analyze the associations between sociodemographic characteristics, including family support, and dementia screening participation.

Results

A total of 62.2% participants received emotional support from their family, and 20.6% received physical support with cleaning, meal preparation, and laundry, general care, nursing, and traveling to the hospital. Of the respondents, 41.8% had participated in dementia screening during the previous 2 years. Older adults with emotional support (OR = 1.41, 95% CI, 1.28–1.54) and physical support (OR = 1.46, 95% CI, 1.31–1.62) were more likely to undergo dementia screening than those without such support. Age, annual household income, education, reason for working, drinking status, exercise, emotional support, and physical support were significantly associated with dementia screening in older adults.

Conclusions

Older adults with low emotional or physical support from family should be considered a vulnerable population with respect to non-participation in dementia screening. Therefore, policies targeting these high-risk groups are needed to increase the dementia screening rate.

目标：韩国是世界上老龄化最快的国家之一，到2025年，痴呆症的患病率预计将上升到10.3%。早期诊断需要尽早获得支持、信息和药物。痴呆症筛查对于痴呆症相关医疗保健项目的成功至关重要。我们调查了痴呆筛查的参与率及其与家庭支持的关系。方法：我们使用了2020年“韩国老年人状况实况调查”的数据，这是一项针对年龄≥65岁的成年人的横断面调查。共分析了9558名受访者。我们使用多变量逻辑回归分析社会人口学特征（包括家庭支持）与痴呆筛查参与之间的关系。结果：共有62.2%的参与者得到了来自家人的情感支持，20.6%的参与者得到了清洁、准备饭菜、洗衣、一般护理、护理和前往医院的身体支持。在受访者中，41.8%的人在过去两年中参加了痴呆症筛查。有情感支持（OR = 1.41, 95% CI, 1.28-1.54）和身体支持（OR = 1.46, 95% CI, 1.31-1.62）的老年人比没有这种支持的老年人更容易接受痴呆症筛查。年龄、家庭年收入、教育程度、工作原因、饮酒状况、运动、情感支持和身体支持与老年人痴呆筛查显著相关。结论：来自家庭的情感或身体支持较低的老年人应被视为不参与痴呆症筛查的弱势群体。因此，需要针对这些高危人群的政策来提高痴呆筛查率。

{"title":"Family support and dementia screening participation among older adults: Evidence from a South Korea fact-finding survey on the status of older adults","authors":"Jieun Kim, Hooyeon Lee","doi":"10.1002/agm2.12380","DOIUrl":"10.1002/agm2.12380","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>South Korea is one of the most rapidly aging societies worldwide and the prevalence of dementia is expected to rise to 10.3% by 2025. Early diagnosis requires early access to support, information, and medication. Dementia screening is important for the success of dementia-related healthcare programs. We investigated the rate of participation in dementia screening and the relationship with family support.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from the 2020 “South Korea fact-finding survey on status of older adults,” a cross-sectional survey targeting adults aged ≥65 years. A total of 9558 respondents were analyzed. We used multivariable logistic regression to analyze the associations between sociodemographic characteristics, including family support, and dementia screening participation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 62.2% participants received emotional support from their family, and 20.6% received physical support with cleaning, meal preparation, and laundry, general care, nursing, and traveling to the hospital. Of the respondents, 41.8% had participated in dementia screening during the previous 2 years. Older adults with emotional support (OR = 1.41, 95% CI, 1.28–1.54) and physical support (OR = 1.46, 95% CI, 1.31–1.62) were more likely to undergo dementia screening than those without such support. Age, annual household income, education, reason for working, drinking status, exercise, emotional support, and physical support were significantly associated with dementia screening in older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Older adults with low emotional or physical support from family should be considered a vulnerable population with respect to non-participation in dementia screening. Therefore, policies targeting these high-risk groups are needed to increase the dementia screening rate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":32862,"journal":{"name":"Aging Medicine","volume":"7 6","pages":"754-760"},"PeriodicalIF":2.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0