Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-58
Arya A, Kumar Sd, Rajkumar V, Sudhan Sr
Background: The treatment of anterior cruciate ligament (ACL) injury includes ACL reconstruction (ACL-R) or ligament preservation, where the former is considered the gold standard. But in meniscal injury, though commonly followed is menisectomy, meniscal repair has gained popularity and success which necessitates the analysis of outcome between ACL-R + meniscal repair and ACL-R + menisectomy as clear consensus have not been established so far in deciding the better overall procedure with respect to function. Methods: This is a prospective, comparative study done in 122 patients with ACL injury and medial/ lateral meniscus in south Indian population at a single center. Where meniscal repair (61) and menisectomy (partial/complete, n=61) with ACL-R were carried out and were evaluated pre-operatively, during the postoperative period at 6 weeks, 3 months, and 6 months of follow-up for function and compared. The primary outcome evaluated was pain and other symptoms like limping, giving way, swelling and locking were also noted and analysed using KOOS, IKDC and Lysholm scores. Results: The mean difference in KOOS score in postoperative period, at 3 and 6months were significantly higher among the ACL-R + meniscal repair group than the ACL-R + meniscectomy group which is statistically significant. Moreover the median percentage change in IKDC and Lysholm scores from baseline to postoperative 3 and 6 months were significantly higher in ACL-R + meniscal repair group than the other. Conclusion: The meniscal repair with ACL-R has a lower failure rate and shows better functional outcomes than the other group which underwent ACL-R and meniscectomy. Keywords: anterior cruciate ligament reconstruction; ACL-R; meniscectomy; meniscal repair; meniscal tear
{"title":"Comparison of anterior cruciate ligament reconstruction with and without concomitant meniscal repair: A prospective comparative study","authors":"Arya A, Kumar Sd, Rajkumar V, Sudhan Sr","doi":"10.17727/jmsr.2023/11-58","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-58","url":null,"abstract":"Background: The treatment of anterior cruciate ligament (ACL) injury includes ACL reconstruction (ACL-R) or ligament preservation, where the former is considered the gold standard. But in meniscal injury, though commonly followed is menisectomy, meniscal repair has gained popularity and success which necessitates the analysis of outcome between ACL-R + meniscal repair and ACL-R + menisectomy as clear consensus have not been established so far in deciding the better overall procedure with respect to function. Methods: This is a prospective, comparative study done in 122 patients with ACL injury and medial/ lateral meniscus in south Indian population at a single center. Where meniscal repair (61) and menisectomy (partial/complete, n=61) with ACL-R were carried out and were evaluated pre-operatively, during the postoperative period at 6 weeks, 3 months, and 6 months of follow-up for function and compared. The primary outcome evaluated was pain and other symptoms like limping, giving way, swelling and locking were also noted and analysed using KOOS, IKDC and Lysholm scores. Results: The mean difference in KOOS score in postoperative period, at 3 and 6months were significantly higher among the ACL-R + meniscal repair group than the ACL-R + meniscectomy group which is statistically significant. Moreover the median percentage change in IKDC and Lysholm scores from baseline to postoperative 3 and 6 months were significantly higher in ACL-R + meniscal repair group than the other. Conclusion: The meniscal repair with ACL-R has a lower failure rate and shows better functional outcomes than the other group which underwent ACL-R and meniscectomy. Keywords: anterior cruciate ligament reconstruction; ACL-R; meniscectomy; meniscal repair; meniscal tear","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-57
Dogiparthi Sn, Mohan S, Bala A, Jenson J
The problems with adverse effects of conventional treatments for a range of dermatological conditions have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as manuka honey, black olives, citrus extracts , pumpkin enzyme extracts for example, has been scientifically recognized for its anti-microbial and skin rejuvenation properties and is now used clinically as a part of medi-facials or as basic low strength peels for skin rejuvenation and for those with sensitive skin. We evaluated the effects of various organic peels on sixty patients over a period of six months by using a grading scale for following skin characteristics post peel procedure; smoothness, firmness, even coloration, normal texture and absence of active skin infections. The overall score in current study was showed that the effectiveness of mandelic peel was more when compared with other organic peels which showed significant difference (p value 0.033). Keywords: sensitive skin; organic peels; medifacials; black olive; manuka honey; pumpkin peel; citrus peel; chemical peels
{"title":"Effectiveness of various organic peels in facial rejuvenation and treatment of sensitive skin","authors":"Dogiparthi Sn, Mohan S, Bala A, Jenson J","doi":"10.17727/jmsr.2023/11-57","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-57","url":null,"abstract":"The problems with adverse effects of conventional treatments for a range of dermatological conditions have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as manuka honey, black olives, citrus extracts , pumpkin enzyme extracts for example, has been scientifically recognized for its anti-microbial and skin rejuvenation properties and is now used clinically as a part of medi-facials or as basic low strength peels for skin rejuvenation and for those with sensitive skin. We evaluated the effects of various organic peels on sixty patients over a period of six months by using a grading scale for following skin characteristics post peel procedure; smoothness, firmness, even coloration, normal texture and absence of active skin infections. The overall score in current study was showed that the effectiveness of mandelic peel was more when compared with other organic peels which showed significant difference (p value 0.033). Keywords: sensitive skin; organic peels; medifacials; black olive; manuka honey; pumpkin peel; citrus peel; chemical peels","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-65
Angampally K, Darapuneni Rc, Gafurjiwala Sm
Background: Transfusion transmitted infections (TTIs) are the major problem associated with blood transfusions, and accurate projections of TTI risk are essential for tracking the safety of the blood supply. This research recognized the seroprevalence trends and shifting patterns of TTIs, in a multispecialty hospital. The aim of the study was to assess the prevalence of TTI infections among blood donors and to compare the changing seroprevalence trends in blood donors. Materials and methods: A cross sectional study was conducted from January 2017 to December 2022 at KIMS Blood Centre, Secunderabad, India. All donors reporting to the blood centre during the period were screened for human immunodeficiency virus (HIV) 1 & 2, hepatitis C viruses, hepatitis B surface antigen (HBsAg), total hepatitis B core antibody (aHBC) and hepatitis B surface antibody (aHBs), malaria and syphilis. Screening of HIV, hepatitis B and hepatitis C viruses were done by chemilumiencies, while syphilis and malaria were screened by RPR method. Results: A total of 69741 voluntary blood donors were screened, of which 68857 were males and 1083 were females. Seropositivity of HIV, hepatitis B, hepatitis C viruses, malaria, syphilis were 0.36 %, 0.59%, 0.48%,0.01% and 0.07% respectively. Addition tests were aHBC and aHBs which showed among all the potential donors, the most common TTI prevalence at our centre was hepatitis B followed by HCV, HIV, syphilis and malaria. Conclusion: Public awareness, careful donor selection, vigilance, and adoption of newer techniques for early detection are needed to reduce the incidence of TTIs. Keywords: human immunodeficiency virus; HIV; hepatitis B; hepatitis C; seroprevalence; transfusion transmitted infections
{"title":"A cross sectional study on seroprevalence of transfusion-transmitted infections among blood donors at tertiary care hospital","authors":"Angampally K, Darapuneni Rc, Gafurjiwala Sm","doi":"10.17727/jmsr.2023/11-65","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-65","url":null,"abstract":"Background: Transfusion transmitted infections (TTIs) are the major problem associated with blood transfusions, and accurate projections of TTI risk are essential for tracking the safety of the blood supply. This research recognized the seroprevalence trends and shifting patterns of TTIs, in a multispecialty hospital. The aim of the study was to assess the prevalence of TTI infections among blood donors and to compare the changing seroprevalence trends in blood donors. Materials and methods: A cross sectional study was conducted from January 2017 to December 2022 at KIMS Blood Centre, Secunderabad, India. All donors reporting to the blood centre during the period were screened for human immunodeficiency virus (HIV) 1 & 2, hepatitis C viruses, hepatitis B surface antigen (HBsAg), total hepatitis B core antibody (aHBC) and hepatitis B surface antibody (aHBs), malaria and syphilis. Screening of HIV, hepatitis B and hepatitis C viruses were done by chemilumiencies, while syphilis and malaria were screened by RPR method. Results: A total of 69741 voluntary blood donors were screened, of which 68857 were males and 1083 were females. Seropositivity of HIV, hepatitis B, hepatitis C viruses, malaria, syphilis were 0.36 %, 0.59%, 0.48%,0.01% and 0.07% respectively. Addition tests were aHBC and aHBs which showed among all the potential donors, the most common TTI prevalence at our centre was hepatitis B followed by HCV, HIV, syphilis and malaria. Conclusion: Public awareness, careful donor selection, vigilance, and adoption of newer techniques for early detection are needed to reduce the incidence of TTIs. Keywords: human immunodeficiency virus; HIV; hepatitis B; hepatitis C; seroprevalence; transfusion transmitted infections","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-49
Chow Cl, Cheng Ch, Chow Wk
In controlling outbreaks of COVID-19, the number of daily confirmed infected cases is useful in deducing parameters to determine emergency management actions such as locking down the cities. However, complicated mathematical models with ordinary differential equations are involved. Resources including manpower and data accessibility are needed. The parameters deduced are always challenged by stakeholders, particularly those from servicing and tourist industry. A simple parameter is proposed to describe the extent of infection by estimating the transient daily infection number divided by the time. The daily infection number in Hong Kong is used to illustrate the approach. This will not require large-scale long-term observation and mathematical modeling or computation. Keywords: COVID-19; infection number; parameter
{"title":"An interesting parameter deduced from confirmed infection number in COVID-19 epidemic","authors":"Chow Cl, Cheng Ch, Chow Wk","doi":"10.17727/jmsr.2023/11-49","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-49","url":null,"abstract":"In controlling outbreaks of COVID-19, the number of daily confirmed infected cases is useful in deducing parameters to determine emergency management actions such as locking down the cities. However, complicated mathematical models with ordinary differential equations are involved. Resources including manpower and data accessibility are needed. The parameters deduced are always challenged by stakeholders, particularly those from servicing and tourist industry. A simple parameter is proposed to describe the extent of infection by estimating the transient daily infection number divided by the time. The daily infection number in Hong Kong is used to illustrate the approach. This will not require large-scale long-term observation and mathematical modeling or computation. Keywords: COVID-19; infection number; parameter","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-64
Subrahmanyam C, Begum N, Chinnabathini S, brunda P, Rao S, Fatima R
Pott’s puffy tumour is most frequently associated with bacterial infection but fungus causing Pott’s puffy tumour is very rare. A case series of three patients with Pott’s puffy tumour caused by fungi of different species like candida, aspergillus, mucor along with the clinical findings and management is presented here. Keywords: Pott’s tumour; fungal aetiology; puffy tumour
{"title":"Potts tumours - Our experience","authors":"Subrahmanyam C, Begum N, Chinnabathini S, brunda P, Rao S, Fatima R","doi":"10.17727/jmsr.2023/11-64","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-64","url":null,"abstract":"Pott’s puffy tumour is most frequently associated with bacterial infection but fungus causing Pott’s puffy tumour is very rare. A case series of three patients with Pott’s puffy tumour caused by fungi of different species like candida, aspergillus, mucor along with the clinical findings and management is presented here. Keywords: Pott’s tumour; fungal aetiology; puffy tumour","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-51
Dhinakaran K, Selvarajan N
Background: Heart failure (HF) is one of the leading causes of hospitalizations in both developed as well as developing nations. The natriuretic peptide N-terminal pro-BNP (NT-proBNP) has long been used for diagnosing and managing HF. The study aimed to determine the correlation of NT-proBNP levels with clinical and echocardiographic features in evaluation of patients admitted with heart failure. Methods: This is retrospective observational study of 37 patients admitted to the hospital with acute onset dyspnea, over a period of 18 months. In addition to detailed history and physical examination, complete blood counts, random blood sugar, blood biochemistry, and electrocardiography (ECG), bedside echocardiography and x-ray chest were performed on admission to the hospital. Measurement of serum NT-proBNP level was performed as part of evaluation of dyspnea. Results: Average age of the study population was 64 years. The co morbidities among the patients were hypertension (91%), diabetes mellitus (68%), obstructive airway disease (21%), coronary artery disease (16%) and chronic kidney disease (4%). The mean NT-proBNP for each group was LVEF ≥ 50%= 2272, LVEF 40–49% = 8161.5, and LVEF < 40% = 17302.7 (pg/ml). Conclusion: NT-proBNP levels are proven to be useful in diagnosing and management of heart failure. However, the levels can be affected by many factors such as age, renal function, anaemia and body mass. When interpreting NT-proBNP levels, these factors have to be taken into account while making clinical decision and initiation of appropriate therapy. Keywords: heart failure; natriuretic peptides; NT- proBNP; hypertension
{"title":"Correlation of NT-proBNP levels with clinical and echocardiographic features in evaluation of patients admitted with heart failure","authors":"Dhinakaran K, Selvarajan N","doi":"10.17727/jmsr.2023/11-51","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-51","url":null,"abstract":"Background: Heart failure (HF) is one of the leading causes of hospitalizations in both developed as well as developing nations. The natriuretic peptide N-terminal pro-BNP (NT-proBNP) has long been used for diagnosing and managing HF. The study aimed to determine the correlation of NT-proBNP levels with clinical and echocardiographic features in evaluation of patients admitted with heart failure. Methods: This is retrospective observational study of 37 patients admitted to the hospital with acute onset dyspnea, over a period of 18 months. In addition to detailed history and physical examination, complete blood counts, random blood sugar, blood biochemistry, and electrocardiography (ECG), bedside echocardiography and x-ray chest were performed on admission to the hospital. Measurement of serum NT-proBNP level was performed as part of evaluation of dyspnea. Results: Average age of the study population was 64 years. The co morbidities among the patients were hypertension (91%), diabetes mellitus (68%), obstructive airway disease (21%), coronary artery disease (16%) and chronic kidney disease (4%). The mean NT-proBNP for each group was LVEF ≥ 50%= 2272, LVEF 40–49% = 8161.5, and LVEF < 40% = 17302.7 (pg/ml). Conclusion: NT-proBNP levels are proven to be useful in diagnosing and management of heart failure. However, the levels can be affected by many factors such as age, renal function, anaemia and body mass. When interpreting NT-proBNP levels, these factors have to be taken into account while making clinical decision and initiation of appropriate therapy. Keywords: heart failure; natriuretic peptides; NT- proBNP; hypertension","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-59
Prasad Hmr, Karthik Lr
Background: Blood donation is crucial aspect of healthcare, ensuring steady supply of safe blood for medical treatments and emergencies. Understanding the beliefs, behaviors and opinions surrounding blood donation is essential for developing effective strategies to promote voluntary blood donation. This cross-sectional study aims to assess and analyze the factors influencing blood donation in Tumkur district of Karnataka, India. Methodology: A cross-sectional community-based study was conducted in Tumkur district over a period of six months. A total of 1000 subjects were included of age 18–65 years from different communities and socioeconomic backgrounds. The structured questionnaire was asked on demographics, knowledge, misunderstandings, previous donation history, willingness and decision-making variables. Results: The study found that while a majority (70%) of the participants were aware of the importance of blood donation, only small proportion (15%) had donated blood previously. Misconceptions and fear of needles were identified as key barriers to blood donation. Moreover, religious and cultural beliefs were observed to influence willingness to donate among certain communities. Younger age, higher education and positive experiences with blood donation drives were associated with an increased likelihood of future donation. Conclusion: Religious and cultural sensitivities should be taken into account when designing donation campaigns in specific communities. Engaging educational institutions and community organizations could play a pivotal role in promoting positive attitude towards blood donation among the youth. It is imperative for healthcare authorities to collaborate with local leaders and stakeholders to develop effective strategies for increasing voluntary blood donation rates in Tumkur district. Keywords: blood donation; beliefs; behaviors; opinions; Tumkur district
{"title":"Assessment of beliefs and attitude towards blood donation among the population of Tumkur district: A cross sectional study","authors":"Prasad Hmr, Karthik Lr","doi":"10.17727/jmsr.2023/11-59","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-59","url":null,"abstract":"Background: Blood donation is crucial aspect of healthcare, ensuring steady supply of safe blood for medical treatments and emergencies. Understanding the beliefs, behaviors and opinions surrounding blood donation is essential for developing effective strategies to promote voluntary blood donation. This cross-sectional study aims to assess and analyze the factors influencing blood donation in Tumkur district of Karnataka, India. Methodology: A cross-sectional community-based study was conducted in Tumkur district over a period of six months. A total of 1000 subjects were included of age 18–65 years from different communities and socioeconomic backgrounds. The structured questionnaire was asked on demographics, knowledge, misunderstandings, previous donation history, willingness and decision-making variables. Results: The study found that while a majority (70%) of the participants were aware of the importance of blood donation, only small proportion (15%) had donated blood previously. Misconceptions and fear of needles were identified as key barriers to blood donation. Moreover, religious and cultural beliefs were observed to influence willingness to donate among certain communities. Younger age, higher education and positive experiences with blood donation drives were associated with an increased likelihood of future donation. Conclusion: Religious and cultural sensitivities should be taken into account when designing donation campaigns in specific communities. Engaging educational institutions and community organizations could play a pivotal role in promoting positive attitude towards blood donation among the youth. It is imperative for healthcare authorities to collaborate with local leaders and stakeholders to develop effective strategies for increasing voluntary blood donation rates in Tumkur district. Keywords: blood donation; beliefs; behaviors; opinions; Tumkur district","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-48
Kesarwani D, Kolte N, Kesarwani A, Jain S
Introduction: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract and their diagnosis is mainly based on histopathology and immunohistochemical study with CD117 marker. However, there are many GIST tumors that are CD117 negative and for such cases come the role of other IHC markers. The study aimed to observe the various histological features and demographic profiles of GISTs and the role of various immunohistochemical markers in the confirmation of diagnosis. Methodology: A hospital-based observational study was conducted on 40 tumor resection materials diagnosed as GIST from April 2017 to February 2023 at tertiary care center K.E.M. Hospital, Pune. All the cases underwent histopathological examination with standard procedure of tissue processing, staining and IHC with CD117. Those cases who were morphologically designated as GIST on HPE were evaluated with a panel of IHC markers like C-KIT, CD34, SMA, desmin, S-100 and vimentin. Results: 35 out of 40 cases (87.5%) were found to be positive for CD117 while IHC markers like CD34, SMA, desmin, S-100 and vimentin were found to be positive in 60%, 20%, 5%, 2.5% and 80% cases respectively. Also, we found significant relationship between histopathological groups different progressive disease risk groups with necrosis, cytologic atypia, cellularity and mucosal invasion (p-value<0.05) Conclusion: In a nutshell, a GIST diagnosis should not be precluded on the basis of morphology only. Use of immunohistochemistry is vital to rule out other mesenchymal tumors and confirmation of GIST. Keywords: GIST; gastrointestinal stromal tumors; IHC; CD 117; histopathology; c-KIT
{"title":"An observational study of gastrointestinal stromal tumors by histopathology and immunohistochemistry","authors":"Kesarwani D, Kolte N, Kesarwani A, Jain S","doi":"10.17727/jmsr.2023/11-48","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-48","url":null,"abstract":"Introduction: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract and their diagnosis is mainly based on histopathology and immunohistochemical study with CD117 marker. However, there are many GIST tumors that are CD117 negative and for such cases come the role of other IHC markers. The study aimed to observe the various histological features and demographic profiles of GISTs and the role of various immunohistochemical markers in the confirmation of diagnosis. Methodology: A hospital-based observational study was conducted on 40 tumor resection materials diagnosed as GIST from April 2017 to February 2023 at tertiary care center K.E.M. Hospital, Pune. All the cases underwent histopathological examination with standard procedure of tissue processing, staining and IHC with CD117. Those cases who were morphologically designated as GIST on HPE were evaluated with a panel of IHC markers like C-KIT, CD34, SMA, desmin, S-100 and vimentin. Results: 35 out of 40 cases (87.5%) were found to be positive for CD117 while IHC markers like CD34, SMA, desmin, S-100 and vimentin were found to be positive in 60%, 20%, 5%, 2.5% and 80% cases respectively. Also, we found significant relationship between histopathological groups different progressive disease risk groups with necrosis, cytologic atypia, cellularity and mucosal invasion (p-value<0.05) Conclusion: In a nutshell, a GIST diagnosis should not be precluded on the basis of morphology only. Use of immunohistochemistry is vital to rule out other mesenchymal tumors and confirmation of GIST. Keywords: GIST; gastrointestinal stromal tumors; IHC; CD 117; histopathology; c-KIT","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-47
Basha Si, Ahmed Kfm, Khan Ama, Kapur P, Shawl Mr, Jain A
Background: Dyspepsia is an upper gastrointestinal disorder affecting 20-45% of the global population. It is characterized by frequent discomfort, burning in the epigastrium and postprandial distress severe enough to hamper routine activities. The aim of this study was to evaluate dyspepsia in young (<40 years) and old patients (>40 years) using ultrasound of abdomen and esophagogastroduodenoscopy as investigative modalities. Methods: The present study was single centre hospital based observational study. 145 patients with dyspepsia were grouped into two categories on the basis of age into those less than and above 40 years of age. All the patients were evaluated using ultrasound of abdomen and esophagogastroduodenoscopy. Results: Epigastric pain was the most common symptom in both groups. It was experienced by 71.23% of the patients less than 40 years and 69.44% of the group above 40 years. Ultrasound examination was normal in majority of patients studied; however more ultrasound abnormalities were detected in the older group of patients. Fatty liver disease was diagnosed in 19.26% younger patients and 48.6% older patients. Cholecystitis and gall bladder polyps were detected only in older patients. Esophagogastroduodenoscopy revealed significant number of abnormalities in both groups. Pangastritis in 21.91% young patients and antral gastritis in 20.80% older patients were the commonest findings in the respective groups. Conclusion: The study concluded that older patients had more frequent organic dyspepsia while younger patients had functional dyspepsia more commonly as evaluated by both esophagogastroduodenoscopy as well as ultrasound examination. Keywords: dyspepsia; endoscopy; esophagogastroduodenoscopy; fatty liver; gastritis; ultrasound
{"title":"Evaluation of dyspepsia in young and old patients using ultrasound of abdomen and esophagogastroduodenoscopy","authors":"Basha Si, Ahmed Kfm, Khan Ama, Kapur P, Shawl Mr, Jain A","doi":"10.17727/jmsr.2023/11-47","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-47","url":null,"abstract":"Background: Dyspepsia is an upper gastrointestinal disorder affecting 20-45% of the global population. It is characterized by frequent discomfort, burning in the epigastrium and postprandial distress severe enough to hamper routine activities. The aim of this study was to evaluate dyspepsia in young (<40 years) and old patients (>40 years) using ultrasound of abdomen and esophagogastroduodenoscopy as investigative modalities. Methods: The present study was single centre hospital based observational study. 145 patients with dyspepsia were grouped into two categories on the basis of age into those less than and above 40 years of age. All the patients were evaluated using ultrasound of abdomen and esophagogastroduodenoscopy. Results: Epigastric pain was the most common symptom in both groups. It was experienced by 71.23% of the patients less than 40 years and 69.44% of the group above 40 years. Ultrasound examination was normal in majority of patients studied; however more ultrasound abnormalities were detected in the older group of patients. Fatty liver disease was diagnosed in 19.26% younger patients and 48.6% older patients. Cholecystitis and gall bladder polyps were detected only in older patients. Esophagogastroduodenoscopy revealed significant number of abnormalities in both groups. Pangastritis in 21.91% young patients and antral gastritis in 20.80% older patients were the commonest findings in the respective groups. Conclusion: The study concluded that older patients had more frequent organic dyspepsia while younger patients had functional dyspepsia more commonly as evaluated by both esophagogastroduodenoscopy as well as ultrasound examination. Keywords: dyspepsia; endoscopy; esophagogastroduodenoscopy; fatty liver; gastritis; ultrasound","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.17727/jmsr.2023/11-50
Prakashiny S, Saranya N, Samuel Tr, Prasad Kh
Introduction: Metabolic acidosis is commonly encountered in chronic kidney disease (CKD) which contributes to its progression. The metabolic acidosis in chronic kidney disease is presumed to be due to accumulation of unmeasured anions leading to a high anion gap (AG). The aim of the study was to assess the metabolic acidosis in renal failure patients using the calculation of delta gap. Methods: 100 renal failure cases were included. Their abnormal urea and creatinine values were utilized to calculate the BUN/creatinine ratio for all the cases. Based on the dipstick urine testing grading, proteinuric renal diseases were identified. The urine and serum osmolality were calculated in these renal failure patients. Serum osmolality was calculated using the values of serum sodium and urea. Urinary density which is also called urine specific gravity was used for indirect calculation of urine osmolality. Modified delta gap equation was applied for quick evaluation of mixed metabolic acid-base disorders. Results: Out of the 100 cases, 41 were proteinuric renal disease cases and 59 were non-proteinuric renal disease cases. High anion gap metabolic acidosis were seen in 65% of the total 100 cases. In 33% of the total cases, non-anion gap metabolic acidosis was also seen in addition to the high anion gap metabolic acidosis as it is evidenced by the delta gap value of less than -6 mmol/L. Conclusions: Earlier identification of the type and causative mechanism of metabolic acidosis in these patients may help to decrease the morbidity and mortality of these patients. The delta gap that can be easily calculated using this quick and short equation at the bedside may serve as a marker in the management of metabolic acidosis in renal failure patients. Keywords: delta gap; modified quick equation; metabolic acidosis; renal failure
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