Pub Date : 2022-07-01DOI: 10.17727/jmsr.2022/10-24
Nagarapu R, Annapoorna Sl, Gurappagari P, Shailaja Vv, Bommala Ml
Corona virus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome–related corona virus 2 (SARS-CoV-2). Most of the infected people experience with mild to moderate respiratory illness and recovering without any special treatment. Present study is intended to identify the number of people infected with COVID-19 at the time of 1st wave (Aug 2020 to Mar 2021), 2nd wave (Apr 2020 to Nov 2021) and 3rd wave (Dec 2021 to Mar 2022) of pandemic situations, also classify the risk category of subjects and future expectations. Total of 67,165 subjects nasopharyngeal swab samples collected from Government General Hospital, Siddipet and Primary Healthcare Centres of all over the Siddipet district, Telangana, India. Out off 67,165 samples during 1st wave 3550 (23.81%) subjects got COVID-19 infection, in that 2341 (15.70%) were males and 1209 (8.11%) were females. During 2nd wave 5697 (16.93%) subjects infected with COVID-19, in that 3566 (10.60%) were males and 2131 (6.33%) were females and during 3rd wave 3064 (16.46%) subjects infected with COVID-19, in that 1968 (10.57%) were males and 1096 (5.89%) were females. In all three time points males were predominantly infected with SARS-CoV2 compare to females. And also 21-40 age group subjects were highly infected at all three time points 1st wave (11.15%), 2nd wave (9.54%) and 3rd wave (8.63%).
{"title":"Qualitative prevalence assessment of SARS-CoV2 infection by comparing first, second and third wave data: A sentinel surveillance testing centre study","authors":"Nagarapu R, Annapoorna Sl, Gurappagari P, Shailaja Vv, Bommala Ml","doi":"10.17727/jmsr.2022/10-24","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-24","url":null,"abstract":"Corona virus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome–related corona virus 2 (SARS-CoV-2). Most of the infected people experience with mild to moderate respiratory illness and recovering without any special treatment. Present study is intended to identify the number of people infected with COVID-19 at the time of 1st wave (Aug 2020 to Mar 2021), 2nd wave (Apr 2020 to Nov 2021) and 3rd wave (Dec 2021 to Mar 2022) of pandemic situations, also classify the risk category of subjects and future expectations. Total of 67,165 subjects nasopharyngeal swab samples collected from Government General Hospital, Siddipet and Primary Healthcare Centres of all over the Siddipet district, Telangana, India. Out off 67,165 samples during 1st wave 3550 (23.81%) subjects got COVID-19 infection, in that 2341 (15.70%) were males and 1209 (8.11%) were females. During 2nd wave 5697 (16.93%) subjects infected with COVID-19, in that 3566 (10.60%) were males and 2131 (6.33%) were females and during 3rd wave 3064 (16.46%) subjects infected with COVID-19, in that 1968 (10.57%) were males and 1096 (5.89%) were females. In all three time points males were predominantly infected with SARS-CoV2 compare to females. And also 21-40 age group subjects were highly infected at all three time points 1st wave (11.15%), 2nd wave (9.54%) and 3rd wave (8.63%).","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45483679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-16
Hegde Ss, Pooja Gs, Prakash Dn, D. S
Background: Although surgical excision is still the gold standard treatment for ocular surface squamous neoplasia (OSSN), interest in conservative medical approaches is steadily growing due to its advantages. The clinical outcome of topical mitomycin C (MMC) as the primary treatment for OSSN was reported. The primary outcome measure was clinical regression of the tumour. The secondary Outcome measures were duration of treatment, possible side effects and recurrences. Materials and methods: In this prospective study 11 patients with the diagnosis of OSSN were included. All were treated with mitomycin C eye drops 0.02% 4 times daily for 4 days a week. Results: Out of the 11 patients, complete tumour regression was achieved in 6 (54.5%) patients. The remaining 5 patients reported partial tumour regression. Mean duration of treatment was 6 weeks. The most common side effect noted was eye irritation. The side effect was transient and resolved with the cessation of treatment. No recurrence was observed during the follow up. Conclusion: Topical chemotherapy can be tried as primary treatment in all patients with OSSN as it can cause complete or partial tumour regression with negligible side effects. Keywords: ocular surface squamous neoplasia; mytomycin C; tumour regression
{"title":"A report on the outcome of topical mitomycin C as the primary treatment for ocular surface squamous neoplasia","authors":"Hegde Ss, Pooja Gs, Prakash Dn, D. S","doi":"10.17727/jmsr.2022/10-16","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-16","url":null,"abstract":"Background: Although surgical excision is still the gold standard treatment for ocular surface squamous neoplasia (OSSN), interest in conservative medical approaches is steadily growing due to its advantages. The clinical outcome of topical mitomycin C (MMC) as the primary treatment for OSSN was reported. The primary outcome measure was clinical regression of the tumour. The secondary Outcome measures were duration of treatment, possible side effects and recurrences. Materials and methods: In this prospective study 11 patients with the diagnosis of OSSN were included. All were treated with mitomycin C eye drops 0.02% 4 times daily for 4 days a week. Results: Out of the 11 patients, complete tumour regression was achieved in 6 (54.5%) patients. The remaining 5 patients reported partial tumour regression. Mean duration of treatment was 6 weeks. The most common side effect noted was eye irritation. The side effect was transient and resolved with the cessation of treatment. No recurrence was observed during the follow up. Conclusion: Topical chemotherapy can be tried as primary treatment in all patients with OSSN as it can cause complete or partial tumour regression with negligible side effects. Keywords: ocular surface squamous neoplasia; mytomycin C; tumour regression","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45994597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-18
Girisha Cn, Rashmi Hd, A. B., Airani Hv
Introduction: Functional endoscopic sinus surgery (FESS) is a minimally invasive procedure which is usually done under general anaesthesia. Laryngoscopy and tracheal intubation may induce an intense sympathetic hemodynamic response which is dangerous in patients with comorbidities. So an effective and safe premedication drug to attenuate this response is very much necessary. Objectives: The present study was designed to compare the effects of oral gabapentin and oral pregabalin as a premedication to produce sedation and attenuate haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing FESS under general anaesthesia. Methods: This prospective, randomized study was undertaken in ENT operation theatre in a Government teaching hospital, Karnataka between July 2020 and June 2021. Group A received gabapentin 600 mg and Group B received pregabalin 150 mg orally one hour prior to induction of general anaesthesia. Results: Patients in both group A and group B were sedated after premedication but the degree of sedation achieved in group B was higher compared to group A (p <0.05). Attenuation of HR and MAP was also higher in group B compared to group A (p <0.05). Conclusion: Premedication with both oral pregabalin 150mg and oral gabapentin 600mg, given 1 hour before general anaesthesia in patients undergoing FESS produce sedation and attenuate hemodynamic response to laryngoscopy and intubation. But premedication with oral pregabalin 150 mg is more effective than oral gabapentin 600 mg in producing sedation and attenuating the hemodynamic responses to laryngoscopy and intubation. Keywords: gabapentin; pregabalin; FESS; anaesthesia
{"title":"Comparative study of gabapentin versus pregabalin as a premedication in patients undergoing FESS under general anaesthesia","authors":"Girisha Cn, Rashmi Hd, A. B., Airani Hv","doi":"10.17727/jmsr.2022/10-18","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-18","url":null,"abstract":"Introduction: Functional endoscopic sinus surgery (FESS) is a minimally invasive procedure which is usually done under general anaesthesia. Laryngoscopy and tracheal intubation may induce an intense sympathetic hemodynamic response which is dangerous in patients with comorbidities. So an effective and safe premedication drug to attenuate this response is very much necessary. Objectives: The present study was designed to compare the effects of oral gabapentin and oral pregabalin as a premedication to produce sedation and attenuate haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing FESS under general anaesthesia. Methods: This prospective, randomized study was undertaken in ENT operation theatre in a Government teaching hospital, Karnataka between July 2020 and June 2021. Group A received gabapentin 600 mg and Group B received pregabalin 150 mg orally one hour prior to induction of general anaesthesia. Results: Patients in both group A and group B were sedated after premedication but the degree of sedation achieved in group B was higher compared to group A (p <0.05). Attenuation of HR and MAP was also higher in group B compared to group A (p <0.05). Conclusion: Premedication with both oral pregabalin 150mg and oral gabapentin 600mg, given 1 hour before general anaesthesia in patients undergoing FESS produce sedation and attenuate hemodynamic response to laryngoscopy and intubation. But premedication with oral pregabalin 150 mg is more effective than oral gabapentin 600 mg in producing sedation and attenuating the hemodynamic responses to laryngoscopy and intubation. Keywords: gabapentin; pregabalin; FESS; anaesthesia","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41402748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-13
B. D., Kanniga R, Ratnani R, R. R.
Introduction: Abnormal uterine bleeding (AUB) is one of the common problems affecting at least one fourth women in reproductive age group. Currently transabdominal and transvaginal sonography is the most commonly used primary screening modality, whereas uterine dilatation and curettage (D&C) is most the commonly used technique for diagnosis and obtain uterine biopsy. However they have various disadvantages. Diagnostic hysteroscopy and biopsy is gradually emerging as the gold standard for AUB. This study evaluates the role of hysteroscopy in diagnosing various intrauterine pathologies. Materials and methods: This study was a hospital record based retrospective observational study. Data of 172 patients who underwent hysteroscopy for AUB were included and hysteroscopic diagnosis was compared with final histopathology to find out the sensitivity, specificity and positive predictive value of hysteroscopy for diagnosing various common intrauterine pathology. Results: Results show that hysteroscopy has high sensitivity and specificity for diagnosis of intrauterine pathology. The study results are in concordance with the findings in few other similar studies. Conclusion: The authors recommend preferring use of this technique over traditional D&C for both diagnostic and therapeutic indications in AUB. Keywords: metrorrhagia, hysteroscopy; uterine; dilatation; curettage
{"title":"Diagnostic hysteroscopy is a better method for diagnosis and management of abnormal uterine bleeding than traditional methods – An Indian perspective","authors":"B. D., Kanniga R, Ratnani R, R. R.","doi":"10.17727/jmsr.2022/10-13","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-13","url":null,"abstract":"Introduction: Abnormal uterine bleeding (AUB) is one of the common problems affecting at least one fourth women in reproductive age group. Currently transabdominal and transvaginal sonography is the most commonly used primary screening modality, whereas uterine dilatation and curettage (D&C) is most the commonly used technique for diagnosis and obtain uterine biopsy. However they have various disadvantages. Diagnostic hysteroscopy and biopsy is gradually emerging as the gold standard for AUB. This study evaluates the role of hysteroscopy in diagnosing various intrauterine pathologies. Materials and methods: This study was a hospital record based retrospective observational study. Data of 172 patients who underwent hysteroscopy for AUB were included and hysteroscopic diagnosis was compared with final histopathology to find out the sensitivity, specificity and positive predictive value of hysteroscopy for diagnosing various common intrauterine pathology. Results: Results show that hysteroscopy has high sensitivity and specificity for diagnosis of intrauterine pathology. The study results are in concordance with the findings in few other similar studies. Conclusion: The authors recommend preferring use of this technique over traditional D&C for both diagnostic and therapeutic indications in AUB. Keywords: metrorrhagia, hysteroscopy; uterine; dilatation; curettage","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46928185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-20
Tanwar Vs, Singh Aa, T. R., S. A, Jatana S, S. S
Antiphospholipid syndrome (APS) is an acquired autoimmune clinical disorder characterized by persistently raised levels of anti-phospholipid antibodies and clinical feature of hypercoagulability (recurrent vascular thrombosis and pregnancy morbidities). Primary APS is idiopathic in nature though secondary APS is associated with other connective tissue diseases like SLE. Here, we present an instance of primary APS with recurrent cerebral venous sinus thrombosis in a youthful unmarried female who clinically presented with generalized epilepsy. Level of anti-cardiolipin (aCL) and anti-beta 2 GP1 antibodies were found elevated on two occasions 12 weeks apart. The patient was treated with anticoagulation therapy along with anti-epileptic therapy and she responded well to the therapy. This case report highlights that clinicians should always suspect APS in female patients who had history of seizures and ischemic or thrombotic lesions on brain imaging, irrespective of presence of pregnancy comorbidities. Keywords: antiphospholipid syndrome; cerebral venous; sinus thrombosis; epilepsy
{"title":"A case of primary antiphospholipid antibody syndrome with intermittent cerebral venous sinus thrombosis manifested with recurrent epilepsy","authors":"Tanwar Vs, Singh Aa, T. R., S. A, Jatana S, S. S","doi":"10.17727/jmsr.2022/10-20","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-20","url":null,"abstract":"Antiphospholipid syndrome (APS) is an acquired autoimmune clinical disorder characterized by persistently raised levels of anti-phospholipid antibodies and clinical feature of hypercoagulability (recurrent vascular thrombosis and pregnancy morbidities). Primary APS is idiopathic in nature though secondary APS is associated with other connective tissue diseases like SLE. Here, we present an instance of primary APS with recurrent cerebral venous sinus thrombosis in a youthful unmarried female who clinically presented with generalized epilepsy. Level of anti-cardiolipin (aCL) and anti-beta 2 GP1 antibodies were found elevated on two occasions 12 weeks apart. The patient was treated with anticoagulation therapy along with anti-epileptic therapy and she responded well to the therapy. This case report highlights that clinicians should always suspect APS in female patients who had history of seizures and ischemic or thrombotic lesions on brain imaging, irrespective of presence of pregnancy comorbidities. Keywords: antiphospholipid syndrome; cerebral venous; sinus thrombosis; epilepsy","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47905686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-19
Sethi S, Kshatri Js, Nayak Rr, Pradhan Pc, Bhoi T
Background: In India, the population of elderly is predicted that it will be increased from 8% in 2015 to 19% in 2050. Geriatric population contributes around 9% of the total Odisha population and 86.3% of them reside in rural areas. The study aimed to estimate the prevalence of diabetes mellitus and find out its risk factors among rural geriatric population in Tigiria block of Odisha, India. Methods: This was a community-based study, cross-sectional in design among 725 rural geriatric populations of Odisha. Socio-demographic information was collected following the standard census of India operational definitions. Self-reported diabetes mellitus status was collected and classified as "present" or "absent". Statistical analysis was performed using "R version 4.0.4". Results: Among the total elderly, 88 (12.13%) participants were diagnosed with diabetes. Common factors found to be significant with diabetes were illiterates (AOR=0.32, CI=0.125-0.817), not working elderly (AOR=2.51, CI=1.103-5.723), high socioeconomic status (AOR=3.79, CI=1.351-10.632) and overweight elderly (AOR=2.19, CI=1.286-3.753) respectively. Conclusion: The frequency of diabetes mellitus among rural geriatric population is less but the risk is high among those not working, literate, with higher SES and overweight elderly group. The researcher should emphasize real-time diagnosis of blood sugar levels using standardized measures among the rural elderly population. Keywords: diabetes mellitus; geriatric population; rural; Odisha
{"title":"Factors affecting diabetes mellitus among rural geriatric population in Tigiria Block of Odisha: Findings from AHSETS study","authors":"Sethi S, Kshatri Js, Nayak Rr, Pradhan Pc, Bhoi T","doi":"10.17727/jmsr.2022/10-19","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-19","url":null,"abstract":"Background: In India, the population of elderly is predicted that it will be increased from 8% in 2015 to 19% in 2050. Geriatric population contributes around 9% of the total Odisha population and 86.3% of them reside in rural areas. The study aimed to estimate the prevalence of diabetes mellitus and find out its risk factors among rural geriatric population in Tigiria block of Odisha, India. Methods: This was a community-based study, cross-sectional in design among 725 rural geriatric populations of Odisha. Socio-demographic information was collected following the standard census of India operational definitions. Self-reported diabetes mellitus status was collected and classified as \"present\" or \"absent\". Statistical analysis was performed using \"R version 4.0.4\". Results: Among the total elderly, 88 (12.13%) participants were diagnosed with diabetes. Common factors found to be significant with diabetes were illiterates (AOR=0.32, CI=0.125-0.817), not working elderly (AOR=2.51, CI=1.103-5.723), high socioeconomic status (AOR=3.79, CI=1.351-10.632) and overweight elderly (AOR=2.19, CI=1.286-3.753) respectively. Conclusion: The frequency of diabetes mellitus among rural geriatric population is less but the risk is high among those not working, literate, with higher SES and overweight elderly group. The researcher should emphasize real-time diagnosis of blood sugar levels using standardized measures among the rural elderly population. Keywords: diabetes mellitus; geriatric population; rural; Odisha","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43805790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-14
C. P, S. A, Anaswara Ks, Kamble N
Background: Tuberculosis is one of the major public health problem, further complicated by the relentless spread of human immunodeficiency virus (HIV). The incidence of drug resistant TB among HIV patients is now increasing. Treatment outcomes in multidrug-resistant tuberculosis (MDR-TB) patients co-infected with HIV is poorly documented. Objectives: Assessed the treatment outcome of MDR-TB co-infected with HIV treated under programmatic management of drug resistant tuberculosis. Methods: The study was conducted in Department of Respiratory Medicine, Princess Krishnajammanni Tuberculosis and Chest Diseases (PK TB & CD) Hospital, Mysore Medical College and Research Institute (MMCRI), Mysore. It is a retrospective study done on patients who were admitted in DRTB center of PK TB & CD hospital, Mysore for initiation of treatment from January 2013 to December 2019. Results: Among the 63 patients studied, 26 patients (41.3%) had a favorable outcome with cure and treatment completed. 25 patients (39.7%) had an unfavorable outcome with death, 9 patients (14.3%) defaulted during the treatment and 2 patients (3.2%) had failure of therapy. Conclusion: Early recognition and treatment of HIV with ART and the clinical stage of the disease during presentation affect the treatment outcome in patients with MDR-TB. Keywords: tuberculosis; HIV; outcome; multidrug resistance; ART
{"title":"Factors associated with treatment outcome of multidrug-resistant tuberculosis patients co-infected with human immunodeficiency virus in a Drug Resistant Tuberculosis Centre","authors":"C. P, S. A, Anaswara Ks, Kamble N","doi":"10.17727/jmsr.2022/10-14","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-14","url":null,"abstract":"Background: Tuberculosis is one of the major public health problem, further complicated by the relentless spread of human immunodeficiency virus (HIV). The incidence of drug resistant TB among HIV patients is now increasing. Treatment outcomes in multidrug-resistant tuberculosis (MDR-TB) patients co-infected with HIV is poorly documented. Objectives: Assessed the treatment outcome of MDR-TB co-infected with HIV treated under programmatic management of drug resistant tuberculosis. Methods: The study was conducted in Department of Respiratory Medicine, Princess Krishnajammanni Tuberculosis and Chest Diseases (PK TB & CD) Hospital, Mysore Medical College and Research Institute (MMCRI), Mysore. It is a retrospective study done on patients who were admitted in DRTB center of PK TB & CD hospital, Mysore for initiation of treatment from January 2013 to December 2019. Results: Among the 63 patients studied, 26 patients (41.3%) had a favorable outcome with cure and treatment completed. 25 patients (39.7%) had an unfavorable outcome with death, 9 patients (14.3%) defaulted during the treatment and 2 patients (3.2%) had failure of therapy. Conclusion: Early recognition and treatment of HIV with ART and the clinical stage of the disease during presentation affect the treatment outcome in patients with MDR-TB. Keywords: tuberculosis; HIV; outcome; multidrug resistance; ART","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45154159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-11
Vedula Rr, Kummary Y, Gurram Sr, Gudipati A, Ponnaganti S, Panigrahi Mk
Background: Controversy continues in the treatment decisions despite advanced imaging techniques. Though specific diagnosis by imaging is not precise. Diffusion weighted imaging is useful in a small proportion of patients. We evaluated the features of magnetic resonance imaging (MRI) with histopathological findings in patients with lesions of the cavernous sinus (CS). Materials and methods: Retrospective analysis of clinical, imaging and histopathological findings of lesions involving cavernous sinus (CS) in 27 consecutive patients was done. Results: The average age of the study population was 41.12 ± 14.49 (13-63) years; with 16 (59.2%) males. Visual disturbances were the most common complaints, reported in 62.0% and cranial nerve involvement was observed in 55 % of the patients. Complete excision was done in nine (33.3%) patients. Post-operative histopathology revealed meningiomas and hemangiomas in six (22.2%) patients each. While, five (18.5%) patients had schwannoma; fungal granuloma was observed in three (11.1%). Imaging based diagnosis showed concordance with histopathology in five (85.0%) patients with hemangioma. Among fungal granuloma, schwannoma and meningiomas, the concordance was 66.6%, 40.0% and 33.3% respectively. In the entire study population, concordance was 44.4%. Conclusions: MR signal intensities are similar in neoplasms, infections, vascular lesions and inflammatory lesions. Cavernous hemangiomas are most often mistaken for other lesions but may be characterized by intense contrast enhancement and absence of restriction of DWI and blooming on GRE sequence. In lesions of cavernous sinus, accuracy of diagnosis on MRI is less than 50%. Diagnosis on MRI is more accurate in hemangiomas and fungal granulomas. Non-invasive diagnosis of granulomatous lesions may help plan appropriate management strategy. Keywords: cavernous sinus; magnetic resonance imaging; diffusion weighted imaging
{"title":"Clinical and imaging features in surgically verified patients over 11 years and literature review","authors":"Vedula Rr, Kummary Y, Gurram Sr, Gudipati A, Ponnaganti S, Panigrahi Mk","doi":"10.17727/jmsr.2022/10-11","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-11","url":null,"abstract":"Background: Controversy continues in the treatment decisions despite advanced imaging techniques. Though specific diagnosis by imaging is not precise. Diffusion weighted imaging is useful in a small proportion of patients. We evaluated the features of magnetic resonance imaging (MRI) with histopathological findings in patients with lesions of the cavernous sinus (CS). Materials and methods: Retrospective analysis of clinical, imaging and histopathological findings of lesions involving cavernous sinus (CS) in 27 consecutive patients was done. Results: The average age of the study population was 41.12 ± 14.49 (13-63) years; with 16 (59.2%) males. Visual disturbances were the most common complaints, reported in 62.0% and cranial nerve involvement was observed in 55 % of the patients. Complete excision was done in nine (33.3%) patients. Post-operative histopathology revealed meningiomas and hemangiomas in six (22.2%) patients each. While, five (18.5%) patients had schwannoma; fungal granuloma was observed in three (11.1%). Imaging based diagnosis showed concordance with histopathology in five (85.0%) patients with hemangioma. Among fungal granuloma, schwannoma and meningiomas, the concordance was 66.6%, 40.0% and 33.3% respectively. In the entire study population, concordance was 44.4%. Conclusions: MR signal intensities are similar in neoplasms, infections, vascular lesions and inflammatory lesions. Cavernous hemangiomas are most often mistaken for other lesions but may be characterized by intense contrast enhancement and absence of restriction of DWI and blooming on GRE sequence. In lesions of cavernous sinus, accuracy of diagnosis on MRI is less than 50%. Diagnosis on MRI is more accurate in hemangiomas and fungal granulomas. Non-invasive diagnosis of granulomatous lesions may help plan appropriate management strategy. Keywords: cavernous sinus; magnetic resonance imaging; diffusion weighted imaging","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45672041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-15
Kılıçaslan O, Savrasova Nm, K. S, Şahin Ie, Öksüz S, K. K
Purpose: The present study aimed to evaluate and estimate the additional and auxiliary diagnostic value of routine laboratory parameters in patients with acute diarrhea caused by rotavirus and adenovirus. Methods/ patients: A total of 6784 patients diagnosed with acute gastroenteritis were evaluated. Rotavirus and adenovirus infection was diagnosed via a Qualitative immunochromatographic combo rapid cassette antigen test. Complete blood count and biochemical blood tests were performed in all the patients and were compared between the groups according to the positivity or negativity of the virus. Results: Rotavirus diarrhea was diagnosed in 16.8% and adenovirus diarrhea in 3.2% of patients. Hemoglobin, hematocrit, and mean cell volume (MCV) levels were lower, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly higher in rotavirus positive cases. Neutrophil to lymphocyte ratio was significantly higher, and lymphocyte to monocyte ratio was significantly lower in positive rotavirus cases than negative ones 2.96 and 2.56, respectively (p<0.001). Conclusions: Hematological and biochemical parameters may assist in diagnosing and distinguishing rotaviral and adenoviral gastroenteritis, especially in low-resource environments. Keywords: adenovirus; children; diarrhea; laboratory markers; rotavirus
{"title":"Role of routine laboratory markers in the diagnosis of rotavirus and adenovirus gastroenteritis","authors":"Kılıçaslan O, Savrasova Nm, K. S, Şahin Ie, Öksüz S, K. K","doi":"10.17727/jmsr.2022/10-15","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-15","url":null,"abstract":"Purpose: The present study aimed to evaluate and estimate the additional and auxiliary diagnostic value of routine laboratory parameters in patients with acute diarrhea caused by rotavirus and adenovirus. Methods/ patients: A total of 6784 patients diagnosed with acute gastroenteritis were evaluated. Rotavirus and adenovirus infection was diagnosed via a Qualitative immunochromatographic combo rapid cassette antigen test. Complete blood count and biochemical blood tests were performed in all the patients and were compared between the groups according to the positivity or negativity of the virus. Results: Rotavirus diarrhea was diagnosed in 16.8% and adenovirus diarrhea in 3.2% of patients. Hemoglobin, hematocrit, and mean cell volume (MCV) levels were lower, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly higher in rotavirus positive cases. Neutrophil to lymphocyte ratio was significantly higher, and lymphocyte to monocyte ratio was significantly lower in positive rotavirus cases than negative ones 2.96 and 2.56, respectively (p<0.001). Conclusions: Hematological and biochemical parameters may assist in diagnosing and distinguishing rotaviral and adenoviral gastroenteritis, especially in low-resource environments. Keywords: adenovirus; children; diarrhea; laboratory markers; rotavirus","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43815123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17727/jmsr.2022/10-17
Mallick Sk, N. G, Deb Ar
Background: The incidence of gallbladder cancer is high in our institute. In India, there is lack of epidemiological study to identify putative risk factors causing gallbladder carcinoma. This study was designed to observe clinical, epidemiological aspects and risk factor of the gallbladder cancer. Early detection and diagnosis will help to decrease gallbladder carcinoma related mortality. Material and methods: After obtaining institutional ethics committee approval, gallbladder cases were identified from the institutional cancer registry. Then those data were tabulated in the excel sheet in the different epidemiological parameters and its outcome responses during June 2019 to December 2020. Results: Among 108 patients gallbladder adenocarcinoma were predominant (89.81%) followed by squamous cell carcinoma (10.19%). Most patients were female (64%) with metastatic presentation (86%). Most commonly encountered risk factors were Gall stone disease (59.26%). 11% patients with porcelain gallbladder causing gallbladder carcinoma were found in this study. Conclusion: The incidence has been on a steady rise in Indian population. The presentation is often with advanced disease and carries dismal prognosis. Most of the patient presented late, due to disease remain silent in early stage and also delayed and few were irregular in follow-up due to COVID-19 pandemic. Further studies with longer duration of follow-up are necessary. Keywords: incidence; hepatitis B & C virus; gallbladder cancer; gallbladder stone
{"title":"Gallbladder cancer in eastern India – The current scenario and the challenges for the future","authors":"Mallick Sk, N. G, Deb Ar","doi":"10.17727/jmsr.2022/10-17","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-17","url":null,"abstract":"Background: The incidence of gallbladder cancer is high in our institute. In India, there is lack of epidemiological study to identify putative risk factors causing gallbladder carcinoma. This study was designed to observe clinical, epidemiological aspects and risk factor of the gallbladder cancer. Early detection and diagnosis will help to decrease gallbladder carcinoma related mortality. Material and methods: After obtaining institutional ethics committee approval, gallbladder cases were identified from the institutional cancer registry. Then those data were tabulated in the excel sheet in the different epidemiological parameters and its outcome responses during June 2019 to December 2020. Results: Among 108 patients gallbladder adenocarcinoma were predominant (89.81%) followed by squamous cell carcinoma (10.19%). Most patients were female (64%) with metastatic presentation (86%). Most commonly encountered risk factors were Gall stone disease (59.26%). 11% patients with porcelain gallbladder causing gallbladder carcinoma were found in this study. Conclusion: The incidence has been on a steady rise in Indian population. The presentation is often with advanced disease and carries dismal prognosis. Most of the patient presented late, due to disease remain silent in early stage and also delayed and few were irregular in follow-up due to COVID-19 pandemic. Further studies with longer duration of follow-up are necessary. Keywords: incidence; hepatitis B & C virus; gallbladder cancer; gallbladder stone","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48012606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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