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In silico Identification and Optimization of Natural Inhibitors for Drug Target Sites in Cryptosporidium parvum: A Review 小隐孢子虫药物靶点天然抑制剂的计算机鉴定与优化综述
Pub Date : 1900-01-01 DOI: 10.51976/ijari.441604
Pratibha Teotia, N. Dwivedi
Cryptosporidium parvum is the most common enteric protozoan pathogens affecting humans worldwide. Currently approved drugs to treat cryptosporidiosis are ineffective and no vaccines exist against C. parvum. Here, We docked benzoxazole derivatives collected from literature with Cryptosporidium parvum inosine 5′-monophosphate dehydrogenase using AutoDock4.2 tool, which resulted in energy-based descriptors such as Binding Energy, Intermolecular Energy, Internal Energy, Torsional Energy, vdW + Hbond + desolv Energy and electrostatic energy. Molecular dynamics (MD) simulation studies were performed through the NAMD graphical user interface embedded in visual molecular dynamics. After that, we have built quantitative structure activity relationship (QSAR) model using energy-based descriptors yielding correlation coefficient r2 of 0.7948. To assess the predictive performance of QSAR model, different cross-validation procedures were adopted. Our results suggests that ligand-receptor binding interactions for inosine 5′-monophosphate dehydrogenase employing QSAR modeling seems to be a promising approach to design more potent inosine 5′-monophosphate dehydrogenase inhibitors prior to their synthesis.
小隐孢子虫是影响人类最常见的肠道原生动物病原体。目前批准的治疗隐孢子虫病的药物是无效的,也没有针对小隐孢子虫的疫苗。本研究利用AutoDock4.2工具将文献中收集的苯并恶唑衍生物与隐孢子虫细小体肌苷5′-单磷酸脱氢酶对接,得到结合能、分子间能、内能、扭能、vdW + Hbond +脱能和静电能等基于能量的描述符。分子动力学(MD)模拟研究是通过嵌入在可视化分子动力学中的NAMD图形用户界面进行的。然后,我们利用基于能量的描述符建立了定量结构活性关系(QSAR)模型,相关系数r2为0.7948。为了评估QSAR模型的预测性能,采用了不同的交叉验证程序。我们的研究结果表明,采用QSAR模型对肌苷5′-单磷酸脱氢酶的配体-受体结合相互作用似乎是一种有前途的方法,可以在合成前设计更有效的肌苷5′-单磷酸脱氢酶抑制剂。
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引用次数: 0
Major Ions Chemistry of Surface Water in Bhindawas Wetland 比达瓦斯湿地地表水主要离子化学研究
Pub Date : 1900-01-01 DOI: 10.51976/ijari.511711
Vandana Shan, S. K. Singh, A. K. Haritash
Water samples were taken from different locations in Bhindawas wetland during summer season for analysing major ion chemistry of surface water and its suitability for irrigation and domestic purpose. Along with some major ions, other general water quality parameters like temperature, pH, TDS, EC and Total Hardness were also analysed. Irrigation quality parameters Sodium Absorption Ratio (SAR), Soluble Sodium Percentage (SSP), Residual Sodium Carbonate (RSC), Kelly’s Ratio(KR) were also investigated. The study was carried out in the month of May, 2016. The results showed that majority of samples were suitable for domestic purpose due to low and medium hardness. The values of pH ranges from 6.5 to 7.4, indicating slightly acidic to alkaline nature of surface water. Total dissolved solids ranges from166 to 344 mg/l. All the sampling locations have SAR value and KR value below 10 and 2 respectively, which indicates excellent water quality of lake for irrigation purposes. Also the values of SSP at each sampling locations is below 50 indicating good water for irrigation. Also RSC value for all the samples range below 2.5 and also suitable for irrigation. According to present study it was found that all the parameters were found within the permissible range and suitable for irrigation and domestic purpose.
在夏季从Bhindawas湿地不同地点采集了水样,分析了地表水的主要离子化学成分及其对灌溉和家庭用途的适用性。除主要离子外,还分析了温度、pH、TDS、EC、总硬度等一般水质参数。灌溉质量参数包括:钠吸收比(SAR)、可溶性钠百分率(SSP)、剩余碳酸钠(RSC)、凯利比(KR)。该研究于2016年5月进行。结果表明,大部分样品硬度较低,中等硬度,适合国内使用。pH值在6.5 ~ 7.4之间,显示了地表水的微酸性到碱性。总溶解固体含量范围为166至344毫克/升。所有采样点的SAR值和KR值分别小于10和2,表明灌溉湖泊水质良好。此外,每个采样点的SSP值都低于50,表明灌溉用水良好。所有样品的RSC值均在2.5以下,也适用于灌溉。根据目前的研究发现,所有参数都在允许范围内,适合灌溉和家庭使用。
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引用次数: 3
Design and Fabrication of the High Pressure Effervescent Spray Combustion System 高压泡腾喷雾燃烧系统的设计与制造
Pub Date : 1900-01-01 DOI: 10.51976/ijari.211427
S. Rehman, K. Zaidi
The purpose of the present work is to design and fabricate the high pressure effervescent spray combustion system for the study of high pressure spray effervescent combustion characteristics. In the present work, the high pressure effervescent spray cylindrical combustion chamber or system was developed by producing internal pressure and temperature due to combustion process approximately equal to 32 bar and 800 K respectively. It is found that curved surface thickness and closed end surface thickness of the cylindrical combustion chamber were 7.42 mm and 15.76 mm respectively.
本工作的目的是设计和制造高压泡腾喷雾燃烧系统,以研究高压泡腾喷雾燃烧特性。本文通过使燃烧过程产生的内压和燃烧过程产生的温度分别约等于32 bar和800 K,研制了高压泡腾喷雾圆柱形燃烧室或系统。结果表明,圆柱形燃烧室的曲面厚度为7.42 mm,封闭端面厚度为15.76 mm。
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引用次数: 2
Analysis of Critical Success Factors for the application of AGVs in the Indian Industry agv在印度工业应用的关键成功因素分析
Pub Date : 1900-01-01 DOI: 10.51976/ijari.922114
Aavriti Arora, Manas Choudhary, Shourya Sahdev, A. Madan
The logistics and e-commerce industry is undergoing a massive shift towards automation and intelligent systems. E-Commerce and logistics businesses are actively deploying Automated Guided Vehicles (AGVS) in warehouses to improve efficiency and save time. Increasing technological advancements have enabled AGVs to become more versatile in their applications. While AGVs have become more adept at their function, market acceptance of AGVs depends on various critical success factors that play an essential role in their widespread adoption. In the present research work, various essential success factors have been determined through research and interaction with experts and academicians. Subsequently, Fuzzy TOPSIS is used to rank the critical success factors (CSFs) based on their relative significance. The results and findings would help design and develop strategies that would enhance the presence of AGVs on shop floors in various industries.
物流和电子商务行业正在经历向自动化和智能系统的大规模转变。电子商务和物流企业积极在仓库部署自动导引车(AGVS),以提高效率和节省时间。不断增长的技术进步使agv在其应用中变得更加通用。虽然agv的功能已经变得更加熟练,但市场对agv的接受程度取决于各种关键的成功因素,这些因素在其广泛采用中起着至关重要的作用。在目前的研究工作中,通过与专家学者的研究和互动,确定了各种必不可少的成功因素。然后,根据关键成功因素的相对重要性,采用模糊TOPSIS对关键成功因素进行排序。结果和发现将有助于设计和制定战略,以提高agv在各个行业车间的存在。
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引用次数: 0
Enhancement in TLS Authentication with RIPEMD-160 RIPEMD-160对TLS认证的增强
Pub Date : 1900-01-01 DOI: 10.51976/ijari.221403
Mian Ahmad Zeb
This paper describes one of the security feature authentication. The main goal of this research is to achieve authentication to identify legal user and minimize the chance of attacks. Internet is open to every body to access and share information on it. Unfortunately, the intruders are also there, to examine a web application and its infrastructure to develop his own design, find the potential weaknesses, and use these weaknesses to break or exploit the application for information steeling. There are different kinds of protocol and methods used for security but still threats to the information on internet. Through authentication process, we can control up to some extend the illegal usage of application. We proposed algorithm for authentication that is RIPEMD -160. RIPEMD-160 will capture overall secure authentication.
本文介绍了认证的安全特性之一。本研究的主要目标是实现身份验证,以识别合法用户,并最大限度地减少攻击的机会。互联网向所有人开放,任何人都可以访问和分享信息。不幸的是,入侵者也在那里,检查web应用程序及其基础设施以开发自己的设计,找到潜在的弱点,并利用这些弱点来破坏或利用应用程序进行信息窃取。有不同的协议和方法用于安全,但仍然威胁着互联网上的信息。通过认证过程,可以在一定程度上控制应用程序的非法使用。我们提出了RIPEMD -160认证算法。RIPEMD-160将捕获整体安全认证。
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引用次数: 0
Star Shape Slotted Microstrip Patch Antenna for Wireless Application 无线应用的星形开槽微带贴片天线
Pub Date : 1900-01-01 DOI: 10.51976/ijari.311512
Nadeem Khan, A. Rai
In this paper three rectangular microstrip patch antennas is designed on the FR4 glass epoxy substrate having the thickness of 1.6 mm. The two antennas contain slots in the form of six corner star. The feeding techniques used in all designs are probe feed. The multiband behavior of printed antennas is analyzed using two slotted structure of rectangular patch antenna. The perposed patch antennas cover the multiband behavior from 1.6 GHz to 6 GHz. The designed antennas are simulated using IE3D electromagnetic simulator. The electrical parameter of the antenna such as return loss, radiation pattern and VSWR exc. are investigated .The simulated antennas is used for wireless application such as IEEE 802.11 (a,b,g and n).
本文在厚度为1.6 mm的FR4玻璃环氧基板上设计了三个矩形微带贴片天线。两根天线包含六角星形状的槽。在所有设计中使用的进料技术都是探针进料。采用矩形贴片天线的双开槽结构,分析了印刷天线的多波段特性。所配置的贴片天线覆盖1.6 GHz至6 GHz的多频段行为。利用IE3D电磁模拟器对所设计的天线进行了仿真。研究了模拟天线的回波损耗、辐射方向图和驻波比等电学参数,并将模拟天线用于IEEE 802.11 (a、b、g和n)等无线应用。
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引用次数: 1
Comparative Studies on Strength of Concrete by Partial Replacement of Cement with Marble Dust and Coconut Fibre 大理石粉与椰子纤维部分替代水泥对混凝土强度的比较研究
Pub Date : 1900-01-01 DOI: 10.51976/ijari.842010
Ravi Kumar, R. Bansal
The cost of building project primarily on the quantity of concrete used during its construction. Cement being the only component manufactured in factories is costly and adds to the cost of a building project. Research work is going on throughout the globe for partial replacement of cement with suitable agriculture waste product such as rice husk ash , fly ash emanating from thermal power plants with the burning of coal, marble powder or coconut coir fiber without hampering the workability as well as strength of concrete. A large amount of coconut fibers is available in coastal region and marble powder exists in Rajasthan .The Feasibility studies on effect of using an admixture of coconut fibers and marble powder on strength of M30 concrete have been conducted . All the instructions, parameters, formulas have been followed according to the bureau of Indian standard. To conduct the test , aggregate consisting of coarse aggregate 20mm and fine sand, 10mm aggregate, marble dust powder, coconut fiber and fresh water have been used. Mix sample of M30 in different variations of ingredients as below have been examined. Four trail mix by varying the percentage of OPC 43 grade of cement, coconut fiber and marble dust powder were prepared and examine for their average compressive strength by the standardized method. It was concluded that M30 mix prepared by 94% of cement with 4% replacement by marble dust powder and adding 2% coconut fiber gives compressive strength of 38.300N/mm2.
建筑工程的成本主要取决于施工过程中使用的混凝土的数量。水泥是工厂生产的唯一部件,成本很高,增加了建筑项目的成本。全球正在进行研究工作,以便用适当的农业废料,如稻壳灰、燃烧煤、大理石粉或椰子纤维产生的粉煤灰等部分替代水泥,而不影响混凝土的和易性和强度。沿海地区有大量的椰子纤维,拉贾斯坦邦有大量的大理石粉,对使用椰子纤维和大理石粉的掺合料对M30混凝土强度的影响进行了可行性研究。所有说明书、参数、配方均按印度标准局标准执行。试验采用粗骨料20mm +细砂、10mm骨料、大理石粉、椰子纤维、淡水组成的骨料。M30的混合样品在不同的变化成分进行了如下检查。制备了不同opc43级水泥、椰子纤维和大理石粉掺量的4种试验混合料,并采用标准化方法测定了其平均抗压强度。结果表明,水泥掺量为94%,大理石粉掺量为4%,椰子纤维掺量为2%的M30混合料抗压强度为38.300N/mm2。
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引用次数: 0
IoT Based System for Alerting Forest Fire and Control of Smuggling 基于物联网的森林火灾预警与走私控制系统
Pub Date : 1900-01-01 DOI: 10.51976/ijari.721904
Saroja Devi H., Meghashree J., S. D. K.
The analysis of environmental conditions in real time (such as weather events and polluting gases) could provide relevant data on the environment that could help prevent or detect an emergency situation. Nowadays, IOT (Internet of Things) devices and sensors allow the monitoring of different environmental variables, such as temperature, humidity, pressure and concentrations of pollutant gases, such as carbon monoxide and carbon dioxide. Radical changes and combinations of these variables could indicate the occurrence of adverse weather events that could cause a natural disaster, such as a forest fire. This paper presents an IoT system that can perform a real time control of fire and tree cut events. Fire usually causes serious hazards. Therefore, to prevent catastrophes that occur in industries, buildings, and forest areas, IOT and sensor based fire detection has become an important issue. In this proposed system, sensors and microcontroller are incorporated to detect the hazardous situations. Light and smoke indicate the chances of fire. If the fire level is mild or severe, then it is alerted by using a buzzer. Tree cuting can be detected by using wireless bend sensor. This helps to prevent tree smuggling and protect forest life. An IOT based system is developed and tested for correct working.
实时分析环境状况(例如天气事件和污染气体)可以提供有关环境的数据,有助于预防或发现紧急情况。如今,物联网(IOT)设备和传感器可以监测不同的环境变量,例如温度、湿度、压力和一氧化碳和二氧化碳等污染气体的浓度。这些变量的剧烈变化和组合可能表明可能导致自然灾害(如森林火灾)的不利天气事件的发生。本文介绍了一种可以实时控制火灾和砍树事件的物联网系统。火灾通常会造成严重的危害。因此,为了防止工业、建筑和森林地区发生的灾难,基于物联网和传感器的火灾探测已成为一个重要问题。在这个系统中,传感器和微控制器被结合在一起来检测危险情况。光和烟表明发生火灾的可能性。如果火灾等级是轻微或严重,则使用蜂鸣器发出警报。使用无线弯曲传感器可以检测采伐树木的情况。这有助于防止树木走私和保护森林生物。开发并测试了基于物联网的系统以确保正确工作。
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引用次数: 1
Industrial Importance of Aluminium-Fly Ash Composite and Its Application-A Review 铝-粉煤灰复合材料的工业意义及其应用综述
Pub Date : 1900-01-01 DOI: 10.51976/ijari.441624
Pankaj Sharma, S. Dwivedi, Vijay Gautam, A. Sharma
The present investigation has been focused on utilization of waste fly ash in useful manner by dispersing it in aluminum matrix to produce composite. In the present work, fly-ash which mainly consists of refractory oxides like silica, alumina, and iron oxides, was used as the reinforcing phase and to increase the wet ability magnesium and silicon were added. Composites were produced with different percentages of reinforcing phase. Al-fly ash composite is electrically conductive and can be processed by ECM, Electrical Discharge Machining (EDM).
研究了将废粉煤灰分散于铝基中制备复合材料的方法。本文以二氧化硅、氧化铝、氧化铁等耐火氧化物为主要成分的粉煤灰为增强相,加入镁和硅来提高湿性。制备了不同增强相含量的复合材料。铝-粉煤灰复合材料具有导电性,可进行电火花加工(ECM)。
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引用次数: 0
Stability and Achieving Maximum Throughput Using Slotted Aloha and Csma with Multipacket Reception 稳定性和实现最大吞吐量使用槽Aloha和Csma与多包接收
Pub Date : 1900-01-01 DOI: 10.51976/ijari.321507
A. Sangeetha, K. Parthiban, R. Gopi
The random access protocols with multi packet reception (MPR), which include both slotted-Aloha and slotted τ-persistent CSMA protocols. For both protocols, each node makes a transmission attempt in a slot with a given probability. The transmission channel is divided into equal slot using slotted-Aloha, then CSMA is used to check whether the channel is idle or not. CSMA is used to avoid collision that is occurred during transmission. Toward receive the optimal transmission probability maximizing a system throughput for both protocols and to develop a simple random access protocol with MPR, this achieves a system throughput close to the maximum value. Optimal transmission probability in the slotted-Aloha protocol is a good approximation for the τ-persistent CSMA protocol. A simple τ-persistent CSMA protocol with MPR is proposed which dynamically adjusts the transmission probability τ depending on the estimated number of active nodes, and thus can achieve a system throughput close to the maximum value.
具有多包接收(MPR)的随机接入协议,包括有槽的aloha和有槽的τ-persistent CSMA协议。对于这两种协议,每个节点以给定的概率在一个槽中进行一次传输尝试。使用slotted-Aloha将传输信道划分为相等的时隙,然后使用CSMA检测信道是否空闲。CSMA用于避免在传输过程中发生碰撞。为了获得两种协议的最优传输概率,使系统吞吐量最大化,并开发具有MPR的简单随机接入协议,使系统吞吐量接近最大值。有隙aloha协议的最优传输概率是τ-persistent CSMA协议的一个很好的近似。提出了一种简单的具有MPR的τ-持久CSMA协议,该协议根据估计的活动节点数动态调整传输概率τ,从而使系统吞吐量接近最大值。
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引用次数: 0
期刊
International Journal of Advance Research and Innovation
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