Background: Methotrexate, the antineoplastic and immunosuppressive drug, is used in the treatment of different types of cancers and the management of chronic inflammatory diseases. Hepatotoxicity is one of its major side effects. Objectives: The present study assesses the hepatoprotective effect of different doses of curcumin and Vitamin C in methotrexate-induced hepatotoxicity. Materials and Methods: The prospective experimental study was conducted at the College of Medicine, Mustansiriyah University, Baghdad, Iraq, and in the animal's house of the Iraqi Center for Cancer Research, Baghdad-Iraq, from November 2020 to June 2021, and comprised Swiss albino female mice aged 3–4 months and weighing 30–40 g each. The mice were divided into 6 groups, the first group was considered as control which received only distilled water, the second group was considered as methotrexate group, third and fourth groups orally supplemented with 10 mg/kg and 20 mg/kg curcumin, respectively, fifth and sixth groups orally supplemented with 100 mg/kg and 200 mg/kg Vitamin C, respectively, The experiment continued for 10 days, and on the 10th day all groups, except the control one, received 20 mg/kg methotrexate intraperitoneally to induce hepatotoxicity. Parameters measured were serum alanine aminotransferase (ALT), aspartate aminotransferase, alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), and liver tissue malondialdehyde (MDA), superoxide dismutase, and glutathione. SPSS 16 was used for data analysis. Results: The results show significant hepatoprotection produced by curcumin reflected by a decrease in LDH and MDA. Vitamin C also produced a significant hepatoprotection demonstrated by a decrease in ALT, ALP, LDH, and MDA. Conclusion: Curcumin and Vitamin C were found to provide hepatoprotection against methotrexate-induced hepatotoxicity through the modulation of oxidative stress biomarkers in a dose-dependent manner.
{"title":"Evaluation of the hepatoprotective effect of different doses of curcumin and vitamin c in methotrexate-induced hepatotoxicity in mice","authors":"Dhekra Khudair, A. Al-Gareeb","doi":"10.4103/mj.mj_5_21","DOIUrl":"https://doi.org/10.4103/mj.mj_5_21","url":null,"abstract":"Background: Methotrexate, the antineoplastic and immunosuppressive drug, is used in the treatment of different types of cancers and the management of chronic inflammatory diseases. Hepatotoxicity is one of its major side effects. Objectives: The present study assesses the hepatoprotective effect of different doses of curcumin and Vitamin C in methotrexate-induced hepatotoxicity. Materials and Methods: The prospective experimental study was conducted at the College of Medicine, Mustansiriyah University, Baghdad, Iraq, and in the animal's house of the Iraqi Center for Cancer Research, Baghdad-Iraq, from November 2020 to June 2021, and comprised Swiss albino female mice aged 3–4 months and weighing 30–40 g each. The mice were divided into 6 groups, the first group was considered as control which received only distilled water, the second group was considered as methotrexate group, third and fourth groups orally supplemented with 10 mg/kg and 20 mg/kg curcumin, respectively, fifth and sixth groups orally supplemented with 100 mg/kg and 200 mg/kg Vitamin C, respectively, The experiment continued for 10 days, and on the 10th day all groups, except the control one, received 20 mg/kg methotrexate intraperitoneally to induce hepatotoxicity. Parameters measured were serum alanine aminotransferase (ALT), aspartate aminotransferase, alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), and liver tissue malondialdehyde (MDA), superoxide dismutase, and glutathione. SPSS 16 was used for data analysis. Results: The results show significant hepatoprotection produced by curcumin reflected by a decrease in LDH and MDA. Vitamin C also produced a significant hepatoprotection demonstrated by a decrease in ALT, ALP, LDH, and MDA. Conclusion: Curcumin and Vitamin C were found to provide hepatoprotection against methotrexate-induced hepatotoxicity through the modulation of oxidative stress biomarkers in a dose-dependent manner.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49051239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Methotrexate (MTX)-induced liver injury is a serious side effect characterized by the increased level of hepatic biomarkers and resulted in acute liver failure. Omega 3 and Vitamin C act as antioxidant that participate in the fighting of free radicals generation during the inflammatory process. Aims: To evaluate the effect of omega 3 and Vitamin C on hepatotoxicity induced by MTX. Settings and Design: 42 (Swiss albino mice) used and divided into six groups (7 mice each): First: Maintained with normal saline, second: Received a single dose injection of MTX (20 mg/kg, intraperitoneally), third: Pretreated with omega 3 100 mg/kg, fourth: Pretreated with omega 3 200 mg/kg, fifth: Pretreated with Vitamin C 100 mg/kg, sixth: Pretreated with Vitamin C 200 mg/kg, then these group injected with MTX on day 10. Subjects and Methods: MTX as 50 mg injection. Omega 3 as capsule 1000 mg. Vitamin C as powder 1000 mg. Assessment of liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]) made using automated computering device (Flexor–EL80) provider by Vitalab (South Africa). Assessment of oxidative stress markers (malondialdehyde [MDA], superoxide dismutase [SOD], reduced glutathione [GSH]) and lactate dehydrogenase (LDH) made by using competitive ELISA kits using (ELISA microplate Humareader). Results: This study showed a significant increase in the liver enzymes (ALT, AST, ALP, and LDH) as well oxidative stress markers (MDA, SOD, and GSH) with severe changes in the histopathological findings (severe inflammatory cell necrosis) among group injected with MTX as compared with control group and illustrated improvement in serum level of ALT, ALP, LDH, MDA, SOD and reduced GSH; besides improved histopathological findings (mild and moderate changes) for a group of mice pretreated with omega 3 and Vitamin C. Conclusions: This study concluded that pretreatment with omega 3 (which was strong antioxidant supplement) and Vitamin C (which was dose-dependent manner with beneficial antioxidant action) exert more hepatoprotective effect against oxidative tissue damage induced by MTX.
{"title":"Effects of omega-3 and vitamin c on methotrexate-induced liver injury","authors":"D. Mohammed, A. Al-Gareeb","doi":"10.4103/mj.mj_6_21","DOIUrl":"https://doi.org/10.4103/mj.mj_6_21","url":null,"abstract":"Context: Methotrexate (MTX)-induced liver injury is a serious side effect characterized by the increased level of hepatic biomarkers and resulted in acute liver failure. Omega 3 and Vitamin C act as antioxidant that participate in the fighting of free radicals generation during the inflammatory process. Aims: To evaluate the effect of omega 3 and Vitamin C on hepatotoxicity induced by MTX. Settings and Design: 42 (Swiss albino mice) used and divided into six groups (7 mice each): First: Maintained with normal saline, second: Received a single dose injection of MTX (20 mg/kg, intraperitoneally), third: Pretreated with omega 3 100 mg/kg, fourth: Pretreated with omega 3 200 mg/kg, fifth: Pretreated with Vitamin C 100 mg/kg, sixth: Pretreated with Vitamin C 200 mg/kg, then these group injected with MTX on day 10. Subjects and Methods: MTX as 50 mg injection. Omega 3 as capsule 1000 mg. Vitamin C as powder 1000 mg. Assessment of liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]) made using automated computering device (Flexor–EL80) provider by Vitalab (South Africa). Assessment of oxidative stress markers (malondialdehyde [MDA], superoxide dismutase [SOD], reduced glutathione [GSH]) and lactate dehydrogenase (LDH) made by using competitive ELISA kits using (ELISA microplate Humareader). Results: This study showed a significant increase in the liver enzymes (ALT, AST, ALP, and LDH) as well oxidative stress markers (MDA, SOD, and GSH) with severe changes in the histopathological findings (severe inflammatory cell necrosis) among group injected with MTX as compared with control group and illustrated improvement in serum level of ALT, ALP, LDH, MDA, SOD and reduced GSH; besides improved histopathological findings (mild and moderate changes) for a group of mice pretreated with omega 3 and Vitamin C. Conclusions: This study concluded that pretreatment with omega 3 (which was strong antioxidant supplement) and Vitamin C (which was dose-dependent manner with beneficial antioxidant action) exert more hepatoprotective effect against oxidative tissue damage induced by MTX.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47164028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stroke at the brain stem and cerebellum may cause sudden vestibular syndromem and isolated audiovestibular loss can herald impeding for infarction at the anterior inferior cerebellar artery territory. Patients complaining sudden isolated dizziness or vertigo are higher chance for the stroke than the general population. Proper bedside assessment of the patient is superior to the imaging such as magnetic resonance imaging for detecting the central cause. Misdiagnosis of the stroke in patient of brain stem vertigo leads to significant morbidity and mortality. The overdiagnosis of this clinical entity will cause unnecessary costly workups and medical treatment. It is important for a clinician to differentiate brain stem vertigo with isolated dizziness or vertigo from the benign disorders of the labyrinth as the treatment strategy and prognosis are different in these two situations. Bedside clinical indicators are often helpful to identify the central pathology, and so neuroimaging should be advised accordingly. This review article focuses on the epidemiology, pathophysiology, clinical presentations, and current management of the brain stem vertigo. This article will surely increase awareness among the clinicians for accurate diagnosis and treatment of the brain stem vertigo.
{"title":"Brainstem vertigo: A brainstorming clinical entity for a clinician","authors":"S. Swain, R. Sahana","doi":"10.4103/MJ.MJ_26_20","DOIUrl":"https://doi.org/10.4103/MJ.MJ_26_20","url":null,"abstract":"Stroke at the brain stem and cerebellum may cause sudden vestibular syndromem and isolated audiovestibular loss can herald impeding for infarction at the anterior inferior cerebellar artery territory. Patients complaining sudden isolated dizziness or vertigo are higher chance for the stroke than the general population. Proper bedside assessment of the patient is superior to the imaging such as magnetic resonance imaging for detecting the central cause. Misdiagnosis of the stroke in patient of brain stem vertigo leads to significant morbidity and mortality. The overdiagnosis of this clinical entity will cause unnecessary costly workups and medical treatment. It is important for a clinician to differentiate brain stem vertigo with isolated dizziness or vertigo from the benign disorders of the labyrinth as the treatment strategy and prognosis are different in these two situations. Bedside clinical indicators are often helpful to identify the central pathology, and so neuroimaging should be advised accordingly. This review article focuses on the epidemiology, pathophysiology, clinical presentations, and current management of the brain stem vertigo. This article will surely increase awareness among the clinicians for accurate diagnosis and treatment of the brain stem vertigo.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47263561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In general, the public health concerns of obesity and hunger appears different, but in reality, the root cause of these problems is overlapping to a great extent. The findings of studies have indicated that childhood obesity and food insecurity can coexist, while in some children and youths, food insecurity has been linked with more risk of development of obesity. Considering the fact that a large section of human population is vulnerable to the threat of food insecurity, it is the need of the hour to take specific interventions to bridge the existing challenges. As the problem has deep roots within the existing system, the first and foremost thing will be to rope in all the concerned stakeholders and plan for a holistic approach. As maintenance of nutrition and ensuring adequate supply of food commodities is an integral aspect of elements of primary health care, the national government should design policies to warrant equitable distribution of food commodities. To conclude, the twin problem of hunger and obesity has demonstrated a significant rise in the different parts of the world. It is of utmost importance to acknowledge the problem as a public health priority and respond to the same in a concerted and organized manner.
{"title":"World's hunger and obesity both on the rise: Time to intervene","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/MJ.MJ_18_19","DOIUrl":"https://doi.org/10.4103/MJ.MJ_18_19","url":null,"abstract":"In general, the public health concerns of obesity and hunger appears different, but in reality, the root cause of these problems is overlapping to a great extent. The findings of studies have indicated that childhood obesity and food insecurity can coexist, while in some children and youths, food insecurity has been linked with more risk of development of obesity. Considering the fact that a large section of human population is vulnerable to the threat of food insecurity, it is the need of the hour to take specific interventions to bridge the existing challenges. As the problem has deep roots within the existing system, the first and foremost thing will be to rope in all the concerned stakeholders and plan for a holistic approach. As maintenance of nutrition and ensuring adequate supply of food commodities is an integral aspect of elements of primary health care, the national government should design policies to warrant equitable distribution of food commodities. To conclude, the twin problem of hunger and obesity has demonstrated a significant rise in the different parts of the world. It is of utmost importance to acknowledge the problem as a public health priority and respond to the same in a concerted and organized manner.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47691232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Due to increasing incidence of Helicobacter pylori infections among children, it is important to understand which diagnostic test among the noninvasive tests is more accurate, specific, and sensitive. Methodology: Forty-five children who underwent osophagogastroduodenoscopy by the same pediatric gastroenterologist, with Urea Breath Test (UBT) and Stool Antigen Test (SAT); their data were analyzed by retrospective study (2013–2019) to make a comparison between UBT and SAT (Specificity, Sensitivity, and Accuracy) using biopsy finding (histopathological finding) as confirmatory tool for diagnosis. Patients were selected according to their clinical presentations and inclusion criteria in this study are: (pediatric age group, have clinical presentation of H. pylori infection, full information in history, clinical examination, and tests). Patients with incomplete information were excluded. Results: Male (75.56%) more common than female (24.44%), abdominal pain (53.3%) is the major presentation followed by hematemesis (20%), UBT is more influenced by demographic characteristics than other tests, UBT has a statistical significant correlation with result of biopsy, also it is more accurate and more sensitive than SAT, but they share same positive predictive value and same specificity. Conclusions: UBT more preferable than SAT specially in children above 6-year-old.
{"title":"Comparison between stool antigen test and urea breath test for diagnosing of Helicobacter pylori infection among Children in Sulaymaniyah City","authors":"A. Hassan, Hamza Ali Faraj, H. Mohammad","doi":"10.4103/MJ.MJ_30_20","DOIUrl":"https://doi.org/10.4103/MJ.MJ_30_20","url":null,"abstract":"Objectives: Due to increasing incidence of Helicobacter pylori infections among children, it is important to understand which diagnostic test among the noninvasive tests is more accurate, specific, and sensitive. Methodology: Forty-five children who underwent osophagogastroduodenoscopy by the same pediatric gastroenterologist, with Urea Breath Test (UBT) and Stool Antigen Test (SAT); their data were analyzed by retrospective study (2013–2019) to make a comparison between UBT and SAT (Specificity, Sensitivity, and Accuracy) using biopsy finding (histopathological finding) as confirmatory tool for diagnosis. Patients were selected according to their clinical presentations and inclusion criteria in this study are: (pediatric age group, have clinical presentation of H. pylori infection, full information in history, clinical examination, and tests). Patients with incomplete information were excluded. Results: Male (75.56%) more common than female (24.44%), abdominal pain (53.3%) is the major presentation followed by hematemesis (20%), UBT is more influenced by demographic characteristics than other tests, UBT has a statistical significant correlation with result of biopsy, also it is more accurate and more sensitive than SAT, but they share same positive predictive value and same specificity. Conclusions: UBT more preferable than SAT specially in children above 6-year-old.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44063607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Imran Nazir, Suhail Rafiq, Mohammad Naseed, M. Dar, F. Shaheen
Background: Meningiomas are the most common intracranial neoplasms. They are usually homogeneously enhancing extraaxial masses. However, 10% of meningiomas are atypical with different imaging appearance. Distinguishing typical from atypical meningiomas on imaging is highly important in surgical and treatment planning. Materials and Methods: Our study was a retrospective one comprising twenty cases each of pathologically proven typical and atypical meningiomas excluding enplaque lesions. Magnetic resonance images were reviewed with each of the lesions showed as dural-based enhancing mass. Individual features analyzed were age, gender, maximum size, location, signal characteristics on T1, T2 weighted, susceptibility weighted imaging , diffusion-weighted, apparent diffusion coefficient, contrast-enhanced T1, interface with adjacent brain tissue, signal changes in adjacent brain tissue, and changes in overlying bone. Aim: The aim of the study is to retrospectively assess the magnetic resonance imaging (MRI) features of pathologically proven typical and atypical meningiomas. Results: Magnetic resonance features such as diffusion restriction, bony changes in form of destruction, indistinct interface with brain parenchyma, heterogeneous postcontrast enhancement, and edematous changes >6 mm thick in adjacent brain parenchyma were in favor of atypical meningioma. Conclusion: MRI has the ability to differentiate typical and atypical meningiomas based on imaging appearance which is important in surgical and treatment planning.
{"title":"Differentiation of typical and atypical meningiomas using magnetic resonance imaging","authors":"Imran Nazir, Suhail Rafiq, Mohammad Naseed, M. Dar, F. Shaheen","doi":"10.4103/MJ.MJ_36_20","DOIUrl":"https://doi.org/10.4103/MJ.MJ_36_20","url":null,"abstract":"Background: Meningiomas are the most common intracranial neoplasms. They are usually homogeneously enhancing extraaxial masses. However, 10% of meningiomas are atypical with different imaging appearance. Distinguishing typical from atypical meningiomas on imaging is highly important in surgical and treatment planning. Materials and Methods: Our study was a retrospective one comprising twenty cases each of pathologically proven typical and atypical meningiomas excluding enplaque lesions. Magnetic resonance images were reviewed with each of the lesions showed as dural-based enhancing mass. Individual features analyzed were age, gender, maximum size, location, signal characteristics on T1, T2 weighted, susceptibility weighted imaging , diffusion-weighted, apparent diffusion coefficient, contrast-enhanced T1, interface with adjacent brain tissue, signal changes in adjacent brain tissue, and changes in overlying bone. Aim: The aim of the study is to retrospectively assess the magnetic resonance imaging (MRI) features of pathologically proven typical and atypical meningiomas. Results: Magnetic resonance features such as diffusion restriction, bony changes in form of destruction, indistinct interface with brain parenchyma, heterogeneous postcontrast enhancement, and edematous changes >6 mm thick in adjacent brain parenchyma were in favor of atypical meningioma. Conclusion: MRI has the ability to differentiate typical and atypical meningiomas based on imaging appearance which is important in surgical and treatment planning.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42675446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introductıon: The aim of this study was to retrospectively evaluate the clinicopathological features of the patients who presented with a mass in the jaw. Materıals and Methods: Clinical files and histopathological records of 69 patients who presented to our clinic with complaints of swelling or mass in the upper or lower jaw between 2010 and 2018 were analyzed retrospectively. Results: Of the cysts and tumoral lesions in patients, 50.7% (35/69) were located in the maxilla and 49.3% (34/69) were located in the mandible. 23 (32.8%) odontogenic cysts, 11 (15,7%) non-odontogenic cysts, 15 (21.4%) odontogenic tumors, 12 (17,4%) local metastases from adjacent tissues to maxilla and mandible, 5 (7.1%) other distant metastases. Among the odontogenic cysts, the most common radicular cysts were 39.13% (10/23), the second had dentigerous cyst 34.78% (8/23). In our 11 patients with non-odontogenic cysts, only nasoalveolar cysts were observed. The distribution of odontogenic tumors are; 40% (6/15) odontoma, 26.6% (4/15) giant cell reparative granuloma, 20% (3/15) ameloblastoma, 6.6% (1/15) rates of cementoma and odontogenic fibroma. Conclusıon: When the etiologic causes of the patients who have complaints of mass in the jaw are examined, we can encounter many different pathologies. Although odontogenic and non-odontogenic cysts are the most common benign masses, we should consider the masses that metastasize to this region and the primary tumors originating from this region.
{"title":"Clinical and pathological examination of jaw masses: Retrospective analysis of 69 cases","authors":"S. Aydın, M. Demir, H. Baran","doi":"10.4103/MJ.MJ_25_20","DOIUrl":"https://doi.org/10.4103/MJ.MJ_25_20","url":null,"abstract":"Introductıon: The aim of this study was to retrospectively evaluate the clinicopathological features of the patients who presented with a mass in the jaw. Materıals and Methods: Clinical files and histopathological records of 69 patients who presented to our clinic with complaints of swelling or mass in the upper or lower jaw between 2010 and 2018 were analyzed retrospectively. Results: Of the cysts and tumoral lesions in patients, 50.7% (35/69) were located in the maxilla and 49.3% (34/69) were located in the mandible. 23 (32.8%) odontogenic cysts, 11 (15,7%) non-odontogenic cysts, 15 (21.4%) odontogenic tumors, 12 (17,4%) local metastases from adjacent tissues to maxilla and mandible, 5 (7.1%) other distant metastases. Among the odontogenic cysts, the most common radicular cysts were 39.13% (10/23), the second had dentigerous cyst 34.78% (8/23). In our 11 patients with non-odontogenic cysts, only nasoalveolar cysts were observed. The distribution of odontogenic tumors are; 40% (6/15) odontoma, 26.6% (4/15) giant cell reparative granuloma, 20% (3/15) ameloblastoma, 6.6% (1/15) rates of cementoma and odontogenic fibroma. Conclusıon: When the etiologic causes of the patients who have complaints of mass in the jaw are examined, we can encounter many different pathologies. Although odontogenic and non-odontogenic cysts are the most common benign masses, we should consider the masses that metastasize to this region and the primary tumors originating from this region.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45229140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A dental professional's personal experience as an author: Innovational and educational approach","authors":"T. Shamim","doi":"10.4103/MJ.MJ_10_20","DOIUrl":"https://doi.org/10.4103/MJ.MJ_10_20","url":null,"abstract":"","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48933193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The international hip dysplasia institute (IHDI) classification is a new method for quantifying the severity of the developmental dysplasia of the hip (DDH). Objectives: This study aimed to compare the reliability of this classification between different medical personnel such as pediatricians, general practitioners, and family doctors in addition to orthopedic surgeons and radiologists. Methods: Hundred pelvic radiographic films (with 200 hips) were randomly selected from the files of children already diagnosed and treated as DDH cases. These films were analyzed by 12 independent observers of four different specialties: three orthopedic surgeons (Ortho Group), three radiologists (Radio Group), three pediatricians (Pediat Group), and three general practitioners (GP Group). Results: The average measures (Cronbach's alpha) for the intraclass correlation coefficient (ICC) for absolute agreement between all observers was 0.874 (with 95% confidence intervals between 0.780 and 0.925). This was considered as having a good level of reliability and agreement between all observers. The ICC for agreement between the observers of radio group showed the highest score (0.904) while that between those of GP Group had the lowest one (0.826). However, during the comparison between the mean score of each group with that of the other groups by the one-way ANOVA method, there was no statistically significant difference between all groups (P values were 0.563, 0.415, 0.399, and 0.291 respectively). Conclusion: The IHDI classification method for cases of DDH has a good level of reliability among different medical personnel regardless of their specialties.
{"title":"Reliability of international hip dysplasia institute classification for the developmental dysplasia of the hip among different medical personnel in Iraq","authors":"J. Doski","doi":"10.4103/mj.mj_9_20","DOIUrl":"https://doi.org/10.4103/mj.mj_9_20","url":null,"abstract":"Background: The international hip dysplasia institute (IHDI) classification is a new method for quantifying the severity of the developmental dysplasia of the hip (DDH). Objectives: This study aimed to compare the reliability of this classification between different medical personnel such as pediatricians, general practitioners, and family doctors in addition to orthopedic surgeons and radiologists. Methods: Hundred pelvic radiographic films (with 200 hips) were randomly selected from the files of children already diagnosed and treated as DDH cases. These films were analyzed by 12 independent observers of four different specialties: three orthopedic surgeons (Ortho Group), three radiologists (Radio Group), three pediatricians (Pediat Group), and three general practitioners (GP Group). Results: The average measures (Cronbach's alpha) for the intraclass correlation coefficient (ICC) for absolute agreement between all observers was 0.874 (with 95% confidence intervals between 0.780 and 0.925). This was considered as having a good level of reliability and agreement between all observers. The ICC for agreement between the observers of radio group showed the highest score (0.904) while that between those of GP Group had the lowest one (0.826). However, during the comparison between the mean score of each group with that of the other groups by the one-way ANOVA method, there was no statistically significant difference between all groups (P values were 0.563, 0.415, 0.399, and 0.291 respectively). Conclusion: The IHDI classification method for cases of DDH has a good level of reliability among different medical personnel regardless of their specialties.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48987278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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