Background: Studies found a link between visceral obesity and insulin resistance (IR). Numerous attempts made to discover a link between fat lipotoxicity and IR by measuring waist circumference (WC) or body mass index (BMI). This study investigates the relationship between body adiposity index [BAI], a body shape index [ABSI], BMI, waist-to-hip ratio [WHR], TGI-WC = Triglyceride glucose index-× WC, and TGI-BMI = Triglyceride glucose index-BMI. Homeostatic model assessment of IR (HOMA-IR) is utilized to examine the significance of those indices in the target population with obesity-linked IR in Iraq. Objective: The aim is to identify the most relevant obesity index by examining the relationship between multiple obesity indices and IR in obese healthy individuals. Design and Methods: 100 obese and nonobese patients' height, weight, and hip circumference were taken. Triglycerides (TGs), glycated hemoglobin (HbA1c), serum insulin, and fasting plasma glucose were obtained to calculate HOMA-IR, TGI-WC, and TGI-BMI. Results: Healthy adults 18–50 years were divided (obese and not-obese), clinical features were averaged, and standard errors of the mean calculated. Results for the first obese group were blood pressure [BP] = 114 ± 2/75 ± 9, HbA1c=5.76 ± 0.09, TG = 175.26 ± 3.66, fasting blood glucose [FBG] = 111.84 ± 1.57, WC = 106.62 ± 1.68, BMI = 32.02 ± 0.69, while those for the second group were BP = 111 ± 8/70 ± 6, HbA1c = 4.41 ± 0.06, TG = 96.36 ± 2.02, FBG = 82.40 ± 1.48, WC = 83.76 ± 0.85, and BMI = 22.84 ± 0.22. The relationships between obesity indices were analyzed with HOMA-IR being judged to be IR when it acquired a score value of ≥ 2. The Pearson's correlation coefficient® used to represent was WHR: r = 0.58, P = 0.0001, ABSI: r = 0.44, P = 0.04, BAI: r = 0.50, P = 0.02, TGI-WC: r = 0.89, P = 0.0001, and TGI-BMI: r = 0.74, P = 0.74. Conclusion: All of the obesity and lipid-related indices investigated were positively correlated with IR. The use of TGI-WC is recommended since it is straightforward to calculate using accessible laboratory tests; it showed the highest (Pearson's) coefficient (r = 0.89; P = 0.0001).
背景:研究发现内脏肥胖与胰岛素抵抗(IR)之间存在联系。许多人试图通过测量腰围(WC)或体重指数(BMI)来发现脂肪毒性和IR之间的联系。本研究探讨体脂指数[BAI]、体型指数[ABSI]、BMI、腰臀比[WHR]、TGI-WC =甘油三酯葡萄糖指数-× WC、TGI-BMI =甘油三酯葡萄糖指数-BMI之间的关系。利用IR的稳态模型评估(HOMA-IR)来检查这些指标在伊拉克肥胖相关IR目标人群中的意义。目的:通过研究肥胖健康人多种肥胖指标与IR的关系，找出最相关的肥胖指标。设计与方法:测定100例肥胖和非肥胖患者的身高、体重和臀围。获取甘油三酯(tg)、糖化血红蛋白(HbA1c)、血清胰岛素和空腹血糖，计算HOMA-IR、TGI-WC和TGI-BMI。结果:将18-50岁的健康成人分为肥胖和非肥胖两组，取临床特征平均值，计算平均值的标准误差。结果第一肥胖组血压(BP) = 114±2/75±9,糖化血红蛋白= 5.76±0.09,TG = 175.26±3.66,空腹血糖(FBG) = 111.84±1.57,WC = 106.62±1.68,体重指数= 32.02±0.69,而第二组BP = 111±8/70±6,糖化血红蛋白= 4.41±0.06,TG = 96.36±2.02,光纤光栅= 82.40±1.48,WC = 83.76±0.85,体重指数= 22.84±0.22。分析肥胖指标之间的关系，当HOMA-IR得分≥2时判断为IR。Pearson相关系数®分别为:WHR: r = 0.58, P = 0.0001, ABSI: r = 0.44, P = 0.04, BAI: r = 0.50, P = 0.02, TGI-WC: r = 0.89, P = 0.0001, TGI-BMI: r = 0.74, P = 0.74。结论:肥胖及血脂相关指标均与IR呈正相关。建议使用TGI-WC，因为使用易于获得的实验室测试可以直接计算;Pearson’s系数最高(r = 0.89);P = 0.0001)。
{"title":"The significance of different obesity parameters in obese participants with insulin resistance","authors":"Ban Ali, Ismail Hussein, Ali Almaliky","doi":"10.4103/mj.mj_19_23","DOIUrl":"https://doi.org/10.4103/mj.mj_19_23","url":null,"abstract":"Background: Studies found a link between visceral obesity and insulin resistance (IR). Numerous attempts made to discover a link between fat lipotoxicity and IR by measuring waist circumference (WC) or body mass index (BMI). This study investigates the relationship between body adiposity index [BAI], a body shape index [ABSI], BMI, waist-to-hip ratio [WHR], TGI-WC = Triglyceride glucose index-× WC, and TGI-BMI = Triglyceride glucose index-BMI. Homeostatic model assessment of IR (HOMA-IR) is utilized to examine the significance of those indices in the target population with obesity-linked IR in Iraq. Objective: The aim is to identify the most relevant obesity index by examining the relationship between multiple obesity indices and IR in obese healthy individuals. Design and Methods: 100 obese and nonobese patients' height, weight, and hip circumference were taken. Triglycerides (TGs), glycated hemoglobin (HbA1c), serum insulin, and fasting plasma glucose were obtained to calculate HOMA-IR, TGI-WC, and TGI-BMI. Results: Healthy adults 18–50 years were divided (obese and not-obese), clinical features were averaged, and standard errors of the mean calculated. Results for the first obese group were blood pressure [BP] = 114 ± 2/75 ± 9, HbA1c=5.76 ± 0.09, TG = 175.26 ± 3.66, fasting blood glucose [FBG] = 111.84 ± 1.57, WC = 106.62 ± 1.68, BMI = 32.02 ± 0.69, while those for the second group were BP = 111 ± 8/70 ± 6, HbA1c = 4.41 ± 0.06, TG = 96.36 ± 2.02, FBG = 82.40 ± 1.48, WC = 83.76 ± 0.85, and BMI = 22.84 ± 0.22. The relationships between obesity indices were analyzed with HOMA-IR being judged to be IR when it acquired a score value of ≥ 2. The Pearson's correlation coefficient® used to represent was WHR: r = 0.58, P = 0.0001, ABSI: r = 0.44, P = 0.04, BAI: r = 0.50, P = 0.02, TGI-WC: r = 0.89, P = 0.0001, and TGI-BMI: r = 0.74, P = 0.74. Conclusion: All of the obesity and lipid-related indices investigated were positively correlated with IR. The use of TGI-WC is recommended since it is straightforward to calculate using accessible laboratory tests; it showed the highest (Pearson's) coefficient (r = 0.89; P = 0.0001).","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44500169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: constrictive pericarditis may cause scarring and consequent loss of the normal elasticity of the pericardial sac. It is caused by idiopathic, viral, following cardiac surgery, radiation, connective tissue disorder, postinfectious (tuberculous or purulent pericarditis), or miscellaneous causes (malignancy, trauma, drug-induced, asbestosis, sarcoidosis, and uremic pericarditis). It is mostly presented by shortness of breath (SOB) due to right-sided failure. Surgical procedure is the cornerstone of management by doing pericardiectomy. Aim of the Study: This study aimed to review the surgical management of constrictive pericarditis and its surgical outcome. Materials and Methods: A retrospective study involved 13 patients with constrictive pericarditis in the Iraqi-cardiac surgery center in Iraqi-Cardiac Surgery Center in Baghdad Medical Complex and Ibn Al-Bitar center for cardiac surgery from 2011 to 2015. Eight (61.5%) of them were female, and the rest (38.5%) were male. Their ages ranged between 10 and 32 years old (the mean age was 21 years). The data were collected from the medical records of the patients. Results: The majority of patients were in the age group of 20–29 years (46.1%). The youngest was 10 years old. Dyspnea on exertion was the most presenting feature (61.5%). In the electrocardiogram, atrial fibrillation was found in three patients (23.2%), and a chest X-ray showed calcium deposition at the pericardium in eight patients (61.5%). Cardiac catheterization (right-sided) and transthoracic echo study also demonstrated the findings of the disease. None of the patients needed the by-pass machine. The biopsy results revealed that tuberculosis (TB) was the most frequent cause of pericarditis. Conclusion: Pericardiectomy is a useful surgical procedure to treat constructive pericarditis, and it was beneficial to all patients in this study, with improvement in their functional capacity. Another finding of significance is that despite intensive vaccination and the use of anti-TB drugs in our country, TB is still an important cause of constrictive pericarditis.
{"title":"Surgical outcome of constrictive pericarditis","authors":"Yaser Saleh Alshimary, Fadhil Alamran, Amra Abbas","doi":"10.4103/mj.mj_22_22","DOIUrl":"https://doi.org/10.4103/mj.mj_22_22","url":null,"abstract":"Background: constrictive pericarditis may cause scarring and consequent loss of the normal elasticity of the pericardial sac. It is caused by idiopathic, viral, following cardiac surgery, radiation, connective tissue disorder, postinfectious (tuberculous or purulent pericarditis), or miscellaneous causes (malignancy, trauma, drug-induced, asbestosis, sarcoidosis, and uremic pericarditis). It is mostly presented by shortness of breath (SOB) due to right-sided failure. Surgical procedure is the cornerstone of management by doing pericardiectomy. Aim of the Study: This study aimed to review the surgical management of constrictive pericarditis and its surgical outcome. Materials and Methods: A retrospective study involved 13 patients with constrictive pericarditis in the Iraqi-cardiac surgery center in Iraqi-Cardiac Surgery Center in Baghdad Medical Complex and Ibn Al-Bitar center for cardiac surgery from 2011 to 2015. Eight (61.5%) of them were female, and the rest (38.5%) were male. Their ages ranged between 10 and 32 years old (the mean age was 21 years). The data were collected from the medical records of the patients. Results: The majority of patients were in the age group of 20–29 years (46.1%). The youngest was 10 years old. Dyspnea on exertion was the most presenting feature (61.5%). In the electrocardiogram, atrial fibrillation was found in three patients (23.2%), and a chest X-ray showed calcium deposition at the pericardium in eight patients (61.5%). Cardiac catheterization (right-sided) and transthoracic echo study also demonstrated the findings of the disease. None of the patients needed the by-pass machine. The biopsy results revealed that tuberculosis (TB) was the most frequent cause of pericarditis. Conclusion: Pericardiectomy is a useful surgical procedure to treat constructive pericarditis, and it was beneficial to all patients in this study, with improvement in their functional capacity. Another finding of significance is that despite intensive vaccination and the use of anti-TB drugs in our country, TB is still an important cause of constrictive pericarditis.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47933621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The bacteria Helicobacter pylori (Hp) has supposed to confirm an oncogenic consequence with the evolution of malignancy events in stomach, effectiveness of Hp consider a top risk factor of gastric-diffuse large B-cell lymphoma (DLBCL). Aims: the aim of this study was to observe the correlation between virulence factors, especially cytotoxin association gene A (CagA) and the progress of gastric DLBCL. Materials and Methods: Biopsy samples (50) involved in this study (28 were men, and 22 women, with a mean age up to 57.64 years), among gastric-DLBCL patients, with (25) control (were 14 men and 11 women) without DLBCL, tested at Medical City Teaching Hospital and Teaching Laboratories, study conducted from January 1st to September 30, 2022. Diagnosis was by molecular methods included DNA extraction for Hp by STR-Format kit (BIORON Diagnostics GmbHm In den Rauhweiden 20,67354 Germany), and “real-time polymerase chain reaction” methods using the (ABI PRISM 7700) Sequence Detection System, also applied the primers and probes, for Hp-CagA. Results: The mean of age was 55.7 ± 2 in DLBCL, while in control were 61.82 + 6, CagA +ve 66.66 + 2. In gastric DLBCL, the red blood cell count, white blood cell count, platelets count, and hemoglobin were all decline in DLBCL, not in the control group, lactate dehydrogenase levels in gastric DLBCL patients were rise (322 U/L), while less in control, while albumin (322g/dl) was less in gastric DLBCL patients. Hp 16S rRNA was detected relating to CagA variety, 66% (33/50) were CagA positive with highly significant in 23 patients with DLBCL (P = 0.004), and 10 in control patients. CagA gene expression was highly expression in gastric DLBCL patients with range up to (+), 8 (++), and 12 (+++), while in the control group was 5 (+), 2 (++), and 3 (+++), respectively. Conclusions: This present study fixed high frequency of CagA gene in gastric DLBCL patients. Moreover, confirmed this gene is significantly associated with gastric DLBCL in patients with Hp. Moreover, genotype EPIYA-ABC motif is related with the high risk of gastric DLBCL.
背景:幽门螺杆菌(Hp)被认为与胃恶性事件的发展具有致癌作用，Hp的有效性被认为是胃弥漫性大b细胞淋巴瘤(DLBCL)的首要危险因素。目的:本研究旨在观察毒力因子，尤其是细胞毒素相关基因A (cytotoxin association gene A, CagA)与胃癌DLBCL进展的相关性。材料与方法:研究于2022年1月1日至9月30日在Medical City教学医院和教学实验室进行，涉及胃-DLBCL患者的活检样本(50例)(男性28例，女性22例，平均年龄57.64岁)，对照组(25例)(男性14例，女性11例)无DLBCL。分子诊断方法包括使用STR-Format试剂盒(BIORON Diagnostics GmbHm In den Rauhweiden 20,67354 Germany)提取Hp的DNA，使用(ABI PRISM 7700)序列检测系统(也使用引物和探针)“实时聚合酶链反应”方法检测Hp- caga。结果:DLBCL患者平均年龄为55.7±2岁，对照组平均年龄为61.82 + 6岁，CagA +ve平均年龄为66.66 + 2岁。在胃DLBCL中，DLBCL患者红细胞计数、白细胞计数、血小板计数、血红蛋白均下降，对照组未见下降;胃DLBCL患者乳酸脱氢酶水平升高(322 U/L)，对照组较低;胃DLBCL患者白蛋白水平较低(322g/dl)。检测到Hp 16S rRNA与CagA种类有关，66%(33/50)的患者CagA阳性，其中DLBCL患者23例(P = 0.004)，对照组10例(P = 0.004)。CagA基因在胃DLBCL患者中高表达，分别为(+)、8(++)和12(+++)，对照组分别为5(+)、2(++)和3(+++)。结论:本研究确定了胃癌DLBCL患者中CagA基因的高频率。此外，证实该基因与Hp患者胃DLBCL显著相关。此外，epyya - abc基序基因型与胃癌DLBCL的高风险相关。
{"title":"Molecular and genetic study for detection of Helicobacter pylori virulence genes among patients with diffuse large B-Cell lymphoma","authors":"Eman Fahad Alhasnawi, Wasan A. Bakir","doi":"10.4103/mj.mj_6_23","DOIUrl":"https://doi.org/10.4103/mj.mj_6_23","url":null,"abstract":"Background: The bacteria Helicobacter pylori (Hp) has supposed to confirm an oncogenic consequence with the evolution of malignancy events in stomach, effectiveness of Hp consider a top risk factor of gastric-diffuse large B-cell lymphoma (DLBCL). Aims: the aim of this study was to observe the correlation between virulence factors, especially cytotoxin association gene A (CagA) and the progress of gastric DLBCL. Materials and Methods: Biopsy samples (50) involved in this study (28 were men, and 22 women, with a mean age up to 57.64 years), among gastric-DLBCL patients, with (25) control (were 14 men and 11 women) without DLBCL, tested at Medical City Teaching Hospital and Teaching Laboratories, study conducted from January 1st to September 30, 2022. Diagnosis was by molecular methods included DNA extraction for Hp by STR-Format kit (BIORON Diagnostics GmbHm In den Rauhweiden 20,67354 Germany), and “real-time polymerase chain reaction” methods using the (ABI PRISM 7700) Sequence Detection System, also applied the primers and probes, for Hp-CagA. Results: The mean of age was 55.7 ± 2 in DLBCL, while in control were 61.82 + 6, CagA +ve 66.66 + 2. In gastric DLBCL, the red blood cell count, white blood cell count, platelets count, and hemoglobin were all decline in DLBCL, not in the control group, lactate dehydrogenase levels in gastric DLBCL patients were rise (322 U/L), while less in control, while albumin (322g/dl) was less in gastric DLBCL patients. Hp 16S rRNA was detected relating to CagA variety, 66% (33/50) were CagA positive with highly significant in 23 patients with DLBCL (P = 0.004), and 10 in control patients. CagA gene expression was highly expression in gastric DLBCL patients with range up to (+), 8 (++), and 12 (+++), while in the control group was 5 (+), 2 (++), and 3 (+++), respectively. Conclusions: This present study fixed high frequency of CagA gene in gastric DLBCL patients. Moreover, confirmed this gene is significantly associated with gastric DLBCL in patients with Hp. Moreover, genotype EPIYA-ABC motif is related with the high risk of gastric DLBCL.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46784445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haider Mohammed Saeed, Sura Aabdulsattar, Abdilkarim Y. Al-Samarriae
Background: A recently discovered lipolytic adipokine called zinc-α2-glycoprotein (ZAG) has been linked to the control of lipid and glucose metabolism in a variety of metabolic diseases. Studies in vivo and in vitro indicate that thyroid hormones (THs) increase the production of ZAG in hepatocytes. Yet, there is little information on how TH might interact with ZAG in a human hyperthyroidism or hypothyroidism model. This study aimed to assess the effect of THs on serum ZAG and its relation to lipid disorder in Iraqi women, who have recently been diagnosed with thyroid dysfunction. Materials and Methods: A case–control study was performed at the Department of Chemistry and Biochemistry/Medicine College in cooperation with National Diabetes Center/University of Mustansiriyah from January 2021 to February 2022. One hundred thirty-two samples were included in this study, all participants are women aged between 21 and 54 years, which were divided into three groups: (44) subjects serve as a control group, (44) patients with newly diagnosed hyperthyroidism, and (44) patients with newly diagnosed hypothyroidism. Results: The results of the current study had shown that the levels of serum ZAG elevated in the patients who have been newly diagnosed with hyperthyroidism (P ≤ 0.001) and decreased in patients with hypothyroidism (P ≤ 0.001) when compared with control. Patients with hyperthyroidism have low levels of cholesterol, triglycerides (TG), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL), while patients with hypothyroidism have higher levels of cholesterol, TG, HDL, and VLDL. Nonetheless, there were no significant correlations between the ZAG and TH with lipid profile in both hyperthyroidism and hypothyroidism. Conclusion: ZAG levels were elevated in patients with hyperthyroidism and decreased in patients with hypothyroidism. There is no correlation between the ZAG and TH with lipid profile in both hyperthyroidism and hypothyroidism.
{"title":"The Association Zinc Alpha 2 Glycoprotein levels with newly diagnosed of thyroid dysfunction in Iraqi women","authors":"Haider Mohammed Saeed, Sura Aabdulsattar, Abdilkarim Y. Al-Samarriae","doi":"10.4103/mj.mj_55_22","DOIUrl":"https://doi.org/10.4103/mj.mj_55_22","url":null,"abstract":"Background: A recently discovered lipolytic adipokine called zinc-α2-glycoprotein (ZAG) has been linked to the control of lipid and glucose metabolism in a variety of metabolic diseases. Studies in vivo and in vitro indicate that thyroid hormones (THs) increase the production of ZAG in hepatocytes. Yet, there is little information on how TH might interact with ZAG in a human hyperthyroidism or hypothyroidism model. This study aimed to assess the effect of THs on serum ZAG and its relation to lipid disorder in Iraqi women, who have recently been diagnosed with thyroid dysfunction. Materials and Methods: A case–control study was performed at the Department of Chemistry and Biochemistry/Medicine College in cooperation with National Diabetes Center/University of Mustansiriyah from January 2021 to February 2022. One hundred thirty-two samples were included in this study, all participants are women aged between 21 and 54 years, which were divided into three groups: (44) subjects serve as a control group, (44) patients with newly diagnosed hyperthyroidism, and (44) patients with newly diagnosed hypothyroidism. Results: The results of the current study had shown that the levels of serum ZAG elevated in the patients who have been newly diagnosed with hyperthyroidism (P ≤ 0.001) and decreased in patients with hypothyroidism (P ≤ 0.001) when compared with control. Patients with hyperthyroidism have low levels of cholesterol, triglycerides (TG), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL), while patients with hypothyroidism have higher levels of cholesterol, TG, HDL, and VLDL. Nonetheless, there were no significant correlations between the ZAG and TH with lipid profile in both hyperthyroidism and hypothyroidism. Conclusion: ZAG levels were elevated in patients with hyperthyroidism and decreased in patients with hypothyroidism. There is no correlation between the ZAG and TH with lipid profile in both hyperthyroidism and hypothyroidism.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48407774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The measurements of the sphenoid and ethmoid sinuses (ESs) are essential in forensic investigations and during endoscopic sinus and skull base surgeries. This study aimed at assessing the dimensions of these sinuses and elucidating their role in sex determination. Materials and Methods: This retrospective assessment was conducted using brain-computed tomographic images stored in the Department of Radiology in a Tertiary hospital in Delta State, Nigeria. After institutional ethical approval, images of 292 patients (115 females and 177 males) aged >20 years, were used to measure the dimensions of the ethmoid and sphenoid sinuses (SSs) bilaterally. These were analyzed and summarized using descriptive statistics. Their association with gender, side, or age was assessed using inferential statistics and considered statistically significant at P < 0.05. Discriminant function analysis of the sinus measurements was conducted to evaluate their accuracy in correct sex prediction. Results: Both sphenoid and ESs showed significant sexual dimorphism. The ESs showed significant asymmetry (P < 0.05). The anterior width of the left ES (79.8%) was the best sex-discriminating variable. The combination of the left sinus dimensions was more accurate (74.3%, 85.3%) than the right sinuses (72.6%, 81.2%) in sex allocation. Using the bilateral ES dimensions yielded a higher accuracy (89.0%) than using bilateral SS parameters (80.1%). Conclusion: The sphenoid and ESs may be used in predicting the sex of an unknown skull bone recovered within the studied population with acceptable accuracy levels.
{"title":"Dimensions of the sphenoid and ethmoid sinuses on computed tomography: Clinical implications and role in sex determination","authors":"B. Ominde, J. Ikubor, W. Iju, P. Igbigbi","doi":"10.4103/mj.mj_59_22","DOIUrl":"https://doi.org/10.4103/mj.mj_59_22","url":null,"abstract":"Background: The measurements of the sphenoid and ethmoid sinuses (ESs) are essential in forensic investigations and during endoscopic sinus and skull base surgeries. This study aimed at assessing the dimensions of these sinuses and elucidating their role in sex determination. Materials and Methods: This retrospective assessment was conducted using brain-computed tomographic images stored in the Department of Radiology in a Tertiary hospital in Delta State, Nigeria. After institutional ethical approval, images of 292 patients (115 females and 177 males) aged >20 years, were used to measure the dimensions of the ethmoid and sphenoid sinuses (SSs) bilaterally. These were analyzed and summarized using descriptive statistics. Their association with gender, side, or age was assessed using inferential statistics and considered statistically significant at P < 0.05. Discriminant function analysis of the sinus measurements was conducted to evaluate their accuracy in correct sex prediction. Results: Both sphenoid and ESs showed significant sexual dimorphism. The ESs showed significant asymmetry (P < 0.05). The anterior width of the left ES (79.8%) was the best sex-discriminating variable. The combination of the left sinus dimensions was more accurate (74.3%, 85.3%) than the right sinuses (72.6%, 81.2%) in sex allocation. Using the bilateral ES dimensions yielded a higher accuracy (89.0%) than using bilateral SS parameters (80.1%). Conclusion: The sphenoid and ESs may be used in predicting the sex of an unknown skull bone recovered within the studied population with acceptable accuracy levels.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41913636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Nasal polyps are a common condition. Their etiology remains unclear. Surgical treatment has been refined significantly over the past 20 years with the advent of endoscopic sinus surgery. Objectives: The objective of this study was to assess the efficacy of functional endoscopic sinus surgery in an adult patient with sinonasal polyposis, by measuring the improvement in symptoms during 6 months of follow-up. Furthermore, record complications and recurrence of nasal polyps. Patients and Methods: A prospective study was conducted between November 2018 to January 2021, which included (39) patients whom attended the Outpatient Otorhinolaryngological Department of AL-Karkh General Hospital and AL-Yarmouk Teaching Hospital and suffered from sinonasal polyposis. This study included patients above 18 years (of either sex) with bilateral nasal polyposis and whom medical treatment failed. Those patients were evaluated by history taking, clinical examination, and computer tomography scan of the nose and paranasal sinuses. All patients had functional endoscopic sinus surgery and visual analog scale assessments was done (both pre- and postoperatively), which followed up for up to 24 weeks. Results: About 79.5% of the patient get improvement in nasal blockage and (66.7%) for hyposmia, (90.5%) for nasal discharge, and (80%) for both headache and postnasal drip associated with significant improvement of symptoms score 24 weeks postoperative to preoperative score for nasal block, hyposmia, nasal discharge, and facial pain, except postnasal drip showed no significant difference. The most frequent complication was a recurrence of polyps, followed by synechiae and minor epistaxis. No major complication was recorded. Conclusion: Endoscopic sinus surgery for sinonasal polyposis is an efficient surgical procedure for nasal polyposis, because it provides an approximate field of vision and illumination, good access, and is associated mostly with minor complications.
{"title":"Outcome of functional endoscopic sinus surgery in adult patient with sinonasal polyposis","authors":"Ali Ali, Ahmed Ahmed, Riyadh Abdul-Aziz","doi":"10.4103/mj.mj_50_22","DOIUrl":"https://doi.org/10.4103/mj.mj_50_22","url":null,"abstract":"Background: Nasal polyps are a common condition. Their etiology remains unclear. Surgical treatment has been refined significantly over the past 20 years with the advent of endoscopic sinus surgery. Objectives: The objective of this study was to assess the efficacy of functional endoscopic sinus surgery in an adult patient with sinonasal polyposis, by measuring the improvement in symptoms during 6 months of follow-up. Furthermore, record complications and recurrence of nasal polyps. Patients and Methods: A prospective study was conducted between November 2018 to January 2021, which included (39) patients whom attended the Outpatient Otorhinolaryngological Department of AL-Karkh General Hospital and AL-Yarmouk Teaching Hospital and suffered from sinonasal polyposis. This study included patients above 18 years (of either sex) with bilateral nasal polyposis and whom medical treatment failed. Those patients were evaluated by history taking, clinical examination, and computer tomography scan of the nose and paranasal sinuses. All patients had functional endoscopic sinus surgery and visual analog scale assessments was done (both pre- and postoperatively), which followed up for up to 24 weeks. Results: About 79.5% of the patient get improvement in nasal blockage and (66.7%) for hyposmia, (90.5%) for nasal discharge, and (80%) for both headache and postnasal drip associated with significant improvement of symptoms score 24 weeks postoperative to preoperative score for nasal block, hyposmia, nasal discharge, and facial pain, except postnasal drip showed no significant difference. The most frequent complication was a recurrence of polyps, followed by synechiae and minor epistaxis. No major complication was recorded. Conclusion: Endoscopic sinus surgery for sinonasal polyposis is an efficient surgical procedure for nasal polyposis, because it provides an approximate field of vision and illumination, good access, and is associated mostly with minor complications.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45801566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Bacterial biofilms can increase the survival of bacteria through providing resistance to conventional disinfectants as well as antibiotics, thus biofilm considered a serious risk to human health with hug loss. Consequently, novel approaches to deal with bacterial biofilms are required. Viruses that may eradicate bacteria are known as bacteriophages, they are also known as “bacteria eaters.” Due to their activity on bacteria, bacteriophages are distinct from other organisms and do not pose a threat to human. Consequently, they are regarded as secure substitutes for antibiotics in the management of bacterial infections. Aim of the Study: In this study, we report the full genome sequencing of bacteriophage, namely BAG1 that targeting an endodontic clinical strain of Enterococcus faecalis (K3). Furthermore, we evaluate it killing efficiency to eliminate E. faecalis in both planktonic media and dentine slabs. Materials and Methods: We used the previously isolated endodontic E. faecalis clinical strain, namely K3 and enterococcus bacteriophage BAG1 in this study by spotting on the double layer agar technique. DNA extracted proceeded with NORGEN phage DNA isolation kit. Phage full genome sequencing was performed using Illumina nova Seq 600, 150 bp PE. In addition, the killing capacity of BAG1 phage against E. faecalis K3 was measured by infecting 5 × 106 E. faecalis with BAG1 phage at multiplicity of infection of 0.1. Furthermore, the biofilm fraction and the number of E. faecalis colony-forming unit in planktonic media were measured after infecting 24 dentine slabs with K3 bacteria and BAG1 phage. SYTO® 9 green LIVE/DEAD® BacLight Bacterial Viability Kits were used to visualize K3 biofilm on dentine slabs using fluorescent microscope. Results: Full Genome Organization of BAG1 phage was circular composed of 68 open reading frame with GC percentage of 34.56%. An efficient killer reflecting by completely eliminating K3 strain within 180 min in killing test. In addition, the result revealed that BAG1 highly significant to eliminate K3 bacteria in both planktonic broth and biofilm fraction obtained from dentine slabs infection with the endodontic K3 clinical strain. Conclusion: Our results support that anti E. faecalis bacteriophage BAG1 significantly eliminate biofilm of E. faecalis K3 on dentine slabs with a lytic properties due to the absence of lysogenic genes which make it a suitable substitute to adjunctive anti E. faecalis therapy.
目的:细菌生物膜可以通过对常规消毒剂和抗生素产生耐药性来提高细菌的存活率，因此生物膜被认为是对人类健康造成严重威胁的生物膜。因此，需要新的方法来处理细菌生物膜。能够消灭细菌的病毒被称为噬菌体，它们也被称为“噬菌者”。由于噬菌体对细菌具有活性，因此与其他生物不同，对人体不构成威胁。因此，它们被认为是细菌感染管理中抗生素的安全替代品。研究目的:在本研究中，我们报道了针对粪肠球菌牙髓临床菌株(K3)的噬菌体BAG1的全基因组测序。此外，我们还评估了它在浮游介质和牙本质板中对粪肠杆菌的杀灭效果。材料与方法:本研究采用双层琼脂法，采用先前分离的根管性粪肠球菌临床菌株K3和肠球菌噬菌体BAG1。用NORGEN噬菌体DNA分离试剂盒提取DNA。噬菌体全基因组测序采用Illumina nova Seq 600, 150 bp PE。此外，以感染倍数为0.1的5 × 106只粪肠杆菌为实验材料，测定了BAG1噬菌体对粪肠杆菌K3的杀伤能力。用K3细菌和BAG1噬菌体分别感染24块牙质平板，测定浮游培养基中粪肠杆菌的生物膜分数和菌落形成单位数量。使用SYTO®9绿色LIVE/DEAD®BacLight细菌活力试剂盒，在荧光显微镜下观察牙本质平板上的K3生物膜。结果:BAG1噬菌体全基因组组织呈圆形，由68个开放阅读框组成，GC率为34.56%。一种有效的杀菌剂，可在180分钟内完全杀灭K3菌株。此外，结果显示BAG1对牙本质板感染后的浮游肉汤和生物膜组分中的K3细菌均有极显著的杀灭作用。结论:抗粪肠杆菌噬菌体BAG1可明显清除粪肠杆菌K3在牙本质板上的生物膜，该生物膜由于缺乏溶原基因而具有溶解性，是抗粪肠杆菌辅助治疗的合适替代品。
{"title":"Killing efficiency and full genome sequencing of bacteriophage BAG1 targeting endodontic clinical strain of Enterococcus faecalis","authors":"Maha Almelan, Uroba Abbas, M. Al‐Zubidi","doi":"10.4103/mj.mj_62_22","DOIUrl":"https://doi.org/10.4103/mj.mj_62_22","url":null,"abstract":"Objectives: Bacterial biofilms can increase the survival of bacteria through providing resistance to conventional disinfectants as well as antibiotics, thus biofilm considered a serious risk to human health with hug loss. Consequently, novel approaches to deal with bacterial biofilms are required. Viruses that may eradicate bacteria are known as bacteriophages, they are also known as “bacteria eaters.” Due to their activity on bacteria, bacteriophages are distinct from other organisms and do not pose a threat to human. Consequently, they are regarded as secure substitutes for antibiotics in the management of bacterial infections. Aim of the Study: In this study, we report the full genome sequencing of bacteriophage, namely BAG1 that targeting an endodontic clinical strain of Enterococcus faecalis (K3). Furthermore, we evaluate it killing efficiency to eliminate E. faecalis in both planktonic media and dentine slabs. Materials and Methods: We used the previously isolated endodontic E. faecalis clinical strain, namely K3 and enterococcus bacteriophage BAG1 in this study by spotting on the double layer agar technique. DNA extracted proceeded with NORGEN phage DNA isolation kit. Phage full genome sequencing was performed using Illumina nova Seq 600, 150 bp PE. In addition, the killing capacity of BAG1 phage against E. faecalis K3 was measured by infecting 5 × 106 E. faecalis with BAG1 phage at multiplicity of infection of 0.1. Furthermore, the biofilm fraction and the number of E. faecalis colony-forming unit in planktonic media were measured after infecting 24 dentine slabs with K3 bacteria and BAG1 phage. SYTO® 9 green LIVE/DEAD® BacLight Bacterial Viability Kits were used to visualize K3 biofilm on dentine slabs using fluorescent microscope. Results: Full Genome Organization of BAG1 phage was circular composed of 68 open reading frame with GC percentage of 34.56%. An efficient killer reflecting by completely eliminating K3 strain within 180 min in killing test. In addition, the result revealed that BAG1 highly significant to eliminate K3 bacteria in both planktonic broth and biofilm fraction obtained from dentine slabs infection with the endodontic K3 clinical strain. Conclusion: Our results support that anti E. faecalis bacteriophage BAG1 significantly eliminate biofilm of E. faecalis K3 on dentine slabs with a lytic properties due to the absence of lysogenic genes which make it a suitable substitute to adjunctive anti E. faecalis therapy.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47685057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The pathogenesis of pulmonary hypertension (PHT) associated with renal failure is complex. It includes metabolic and hormonal changes, high cardiac output due to arteriovenous fistula (AVF), anemia, and other factors. Objectives: The objective is to identify PHT frequency and associated factors in patients on hemodialysis (HD) compared to patients, not on HD. Methods: A cross-sectional study was conducted at Ibn Sena teaching hospital/Mosul and included 100 diabetic males with end-stage renal disease on HD (Group 1) compared to 96 diabetic males (of similar age) with chronic kidney disease but not on HD (Group 2) to assess the pulmonary artery pressure using Doppler echocardiogram. Patients with other causes of PHT such as heart failure and chronic lung disease were excluded from the study. Results: 42 (42%) of patients in Group 1 had PHT and 12 (12.5%) patients in Group 2. There were statistically significant differences between patients with and without PHT regarding ejection fraction (EF), but no significant differences regarding age, duration of dialysis, hemoglobin (Hb), and vascular access type in both groups. Conclusions: EF had a relationship with PHT, whereas the duration of dialysis, age of patients, Hb, and dialysis access type had no relationship to PHT. Recommendations: More studies are needed in our country regarding PHT in patients with variable stages of renal disease with larger sample sizes and different designs with the inclusion of data and parameters that were missing in our study such as duration of AVF creation.
{"title":"Pulmonary hypertension in a group of patients with various stages of renal disease","authors":"Sayf Hassan, Qais Al-Omary, Ahmad Aldeen","doi":"10.4103/mj.mj_28_22","DOIUrl":"https://doi.org/10.4103/mj.mj_28_22","url":null,"abstract":"Background: The pathogenesis of pulmonary hypertension (PHT) associated with renal failure is complex. It includes metabolic and hormonal changes, high cardiac output due to arteriovenous fistula (AVF), anemia, and other factors. Objectives: The objective is to identify PHT frequency and associated factors in patients on hemodialysis (HD) compared to patients, not on HD. Methods: A cross-sectional study was conducted at Ibn Sena teaching hospital/Mosul and included 100 diabetic males with end-stage renal disease on HD (Group 1) compared to 96 diabetic males (of similar age) with chronic kidney disease but not on HD (Group 2) to assess the pulmonary artery pressure using Doppler echocardiogram. Patients with other causes of PHT such as heart failure and chronic lung disease were excluded from the study. Results: 42 (42%) of patients in Group 1 had PHT and 12 (12.5%) patients in Group 2. There were statistically significant differences between patients with and without PHT regarding ejection fraction (EF), but no significant differences regarding age, duration of dialysis, hemoglobin (Hb), and vascular access type in both groups. Conclusions: EF had a relationship with PHT, whereas the duration of dialysis, age of patients, Hb, and dialysis access type had no relationship to PHT. Recommendations: More studies are needed in our country regarding PHT in patients with variable stages of renal disease with larger sample sizes and different designs with the inclusion of data and parameters that were missing in our study such as duration of AVF creation.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48321147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This study investigated the potential role of ivabradine (Nebivolol and Atenolol) in the attenuation of doxorubicin induced cardiotoxicity in mice. So we will seek the role of nebivolol and atenolol in reducing cardiotoxicity induced by doxorubicin in this experimental study. Aims: To investigate the potential roles of nebivolol and atenolol in the attenuation of doxorubicin (DXR)-induced cardiotoxicity in mice. Materials and Methods: A total of 42 Swiss-Albino male and female mice were used, which were divided into six equal groups: A negative control, a group 1 not received any agents, group 2 (DXR group) received a single dose of DXR 15 mg/kg, treated group 3 was pretreated with nebivolol 15 mg/kg plus DXR. Treated group 4 was pretreated with nebivolol 30 mg/kg plus DXR. Treated group 5 was pretreated with Atenolol 45 mg/kg plus DXR, and treated group 6 was pretreated with atenolol 90 mg/kg plus DXR. The duration of the study was 10 days. Inflammatory biomarkers including tumor necrosis factor-alpha (TNF-α), lactate dehydrogenase (LDH), malondialdehyde (MDA), and cardiac troponin (cTn-I) serum levels were measured. SPSS version 28.00 was used for data analysis. Results: TNF-α, LDH, MDA, and cTn-I serum levels were higher in the DXR-treated mice as compared to the control (P < 0.05). Nebivolol and atenolol produced a dose-dependent effect in the reduction of TNF-α, LDH, MDA, and cTn-I serum levels as compared to the DXR-treated mice (P < 0.05). Conclusion: Atenolol and nebivolol were effective agents in the mitigation of DXR-induced cardiotoxicity by their anti-inflammatory effects of both atenolol and nebivolol and antioxidant effects of nebivolol. Atenolol and nebivolol illustrated a dose-dependent effect in the attenuation of DXR-induced cardiotoxicity through inhibition of lipid peroxidation and cardiomyocyte injury.
{"title":"Nebivolol and atenolol roles in doxorubicin-induced cardiotoxicity","authors":"Hajer K. Issa, A. Al-Gareeb","doi":"10.4103/mj.mj_18_22","DOIUrl":"https://doi.org/10.4103/mj.mj_18_22","url":null,"abstract":"Background: This study investigated the potential role of ivabradine (Nebivolol and Atenolol) in the attenuation of doxorubicin induced cardiotoxicity in mice. So we will seek the role of nebivolol and atenolol in reducing cardiotoxicity induced by doxorubicin in this experimental study. Aims: To investigate the potential roles of nebivolol and atenolol in the attenuation of doxorubicin (DXR)-induced cardiotoxicity in mice. Materials and Methods: A total of 42 Swiss-Albino male and female mice were used, which were divided into six equal groups: A negative control, a group 1 not received any agents, group 2 (DXR group) received a single dose of DXR 15 mg/kg, treated group 3 was pretreated with nebivolol 15 mg/kg plus DXR. Treated group 4 was pretreated with nebivolol 30 mg/kg plus DXR. Treated group 5 was pretreated with Atenolol 45 mg/kg plus DXR, and treated group 6 was pretreated with atenolol 90 mg/kg plus DXR. The duration of the study was 10 days. Inflammatory biomarkers including tumor necrosis factor-alpha (TNF-α), lactate dehydrogenase (LDH), malondialdehyde (MDA), and cardiac troponin (cTn-I) serum levels were measured. SPSS version 28.00 was used for data analysis. Results: TNF-α, LDH, MDA, and cTn-I serum levels were higher in the DXR-treated mice as compared to the control (P < 0.05). Nebivolol and atenolol produced a dose-dependent effect in the reduction of TNF-α, LDH, MDA, and cTn-I serum levels as compared to the DXR-treated mice (P < 0.05). Conclusion: Atenolol and nebivolol were effective agents in the mitigation of DXR-induced cardiotoxicity by their anti-inflammatory effects of both atenolol and nebivolol and antioxidant effects of nebivolol. Atenolol and nebivolol illustrated a dose-dependent effect in the attenuation of DXR-induced cardiotoxicity through inhibition of lipid peroxidation and cardiomyocyte injury.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43778569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ihab Alaqrabawi, Zuhdi O Elifranji, M. Alshrouf, Abdulrahman Karam, Aseel N Abdin, Jihad Al-Ajlouni
Reconstruction of severe bone loss and large skeletal defects using biologic materials with autograft or allograft and using tumor endoprostheses (megaprostheses) helped orthopedic surgeons as well as patients in the sparing of limbs. Several types of megaprostheses have been described in the literature for oncological indications with unpredictable outcomes and complication rates. We review single-centered experience of three nononcological cases to assess the safety of using megaprostheses in patients with severe bone loss without malignant disease. In addition, a literature review on the previous use of megaprostheses as treatment modality, their outcome, and complications was done until August 2022. All the participants were found to be good candidates for megaprostheses implants after their refusal of amputation. Their infections were eradicated before the implants, and also, the range of movement and improvements are satisfactory. In addition, according to the literature compared to the alternative of amputation, this operation has proven to be life-altering and revolutionary for many patients. We believe that megaprostheses might be a good limb salvage alternative in patients with significant bone loss and massive skeletal deformities, even in nononcological situations. Future studies should focus on ways to improve the material and design of the megaprostheses and study the long-term complications and survival rate of the implants.
{"title":"The use of megaprostheses in severe bone loss due to nononcological indications: Three case reports and literature review","authors":"Ihab Alaqrabawi, Zuhdi O Elifranji, M. Alshrouf, Abdulrahman Karam, Aseel N Abdin, Jihad Al-Ajlouni","doi":"10.4103/mj.mj_1_22","DOIUrl":"https://doi.org/10.4103/mj.mj_1_22","url":null,"abstract":"Reconstruction of severe bone loss and large skeletal defects using biologic materials with autograft or allograft and using tumor endoprostheses (megaprostheses) helped orthopedic surgeons as well as patients in the sparing of limbs. Several types of megaprostheses have been described in the literature for oncological indications with unpredictable outcomes and complication rates. We review single-centered experience of three nononcological cases to assess the safety of using megaprostheses in patients with severe bone loss without malignant disease. In addition, a literature review on the previous use of megaprostheses as treatment modality, their outcome, and complications was done until August 2022. All the participants were found to be good candidates for megaprostheses implants after their refusal of amputation. Their infections were eradicated before the implants, and also, the range of movement and improvements are satisfactory. In addition, according to the literature compared to the alternative of amputation, this operation has proven to be life-altering and revolutionary for many patients. We believe that megaprostheses might be a good limb salvage alternative in patients with significant bone loss and massive skeletal deformities, even in nononcological situations. Future studies should focus on ways to improve the material and design of the megaprostheses and study the long-term complications and survival rate of the implants.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46185239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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