Pub Date : 2015-07-01DOI: 10.4103/0331-3131.177949
J. El-Bashir, F. Abbiyesuku, I. Aliyu, A. Randawa, R. Adamu, S. Adamu, S. Akuyam, M. Manu, H. Suleiman, R. Yusuf, A. Mohammed
Background: Thyroid disorders are the second most common endocrine disorders found during pregnancy. Normal maternal thyroid function is critical for normal fetal development. Gestational thyroid dysfunctions complicate pregnancy with a significant increase in maternal and perinatal morbidity and mortality. Objective: To assess the prevalence of thyroid disorders among pregnant women in Zaria. Materials and Methods: Study population consisted of 300 apparently healthy pregnant women and 100 apparently healthy age-matched nonpregnant controls. Participants were not on any drug that can affect thyroid function. Serum thyroid hormones [thyroid stimulating hormone, free triiodothyronine (T 3 ), free thyroxine (T 4 ), and thyroid peroxidase (TPO) antibody] were assayed using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using Epi Info 3.5.3 and P-values ≤0.05 were considered statistically significant. Results: Ages (mean ± SD) were 25.41 ± 5.98 and 26.70 ± 5.83 years for pregnant women and controls, respectively. Parity mean ± SD were 2.32 ± 2.24 and 2.63 ± 2.75 for pregnant women and controls, respectively. The mean gestational age ± SD was 21.68 ± 10.38 weeks. Three percent (3%) were hypothyroid, while 2.3% were hyperthyroid. Nine percent (9%) were TPO antibody positive. Conclusion: Prevalence of thyroid disorders among pregnant women in Zaria was high therefore routine screening of all pregnant women for thyroid disorders during antenatal care visits may be of benefit.
背景:甲状腺疾病是妊娠期间第二常见的内分泌疾病。正常的母体甲状腺功能对胎儿的正常发育至关重要。妊娠期甲状腺功能障碍使妊娠复杂化，孕产妇和围产期发病率和死亡率显著增加。目的:了解扎里亚地区孕妇甲状腺疾病的患病率。材料与方法:研究人群包括300名明显健康的孕妇和100名明显健康的年龄匹配的非孕妇对照。参与者没有服用任何影响甲状腺功能的药物。采用酶联免疫吸附法(ELISA)检测血清甲状腺激素[促甲状腺激素、游离三碘甲状腺原氨酸(t3)、游离甲状腺素(t4)、甲状腺过氧化物酶(TPO)抗体]。数据采用Epi Info 3.5.3进行分析，p值≤0.05为差异有统计学意义。结果:孕妇和对照组的年龄(平均±SD)分别为25.41±5.98岁和26.70±5.83岁。孕妇和对照组的胎次平均值±SD分别为2.32±2.24和2.63±2.75。平均胎龄±SD为21.68±10.38周。3%(3%)为甲状腺功能减退，2.3%为甲状腺功能亢进。9% (9%) TPO抗体阳性。结论:扎里亚州孕妇甲状腺疾病的患病率很高，因此在产前检查期间对所有孕妇进行甲状腺疾病的常规筛查可能是有益的。
{"title":"Prevalence of gestational thyroid disorders in Zaria, north-western Nigeria","authors":"J. El-Bashir, F. Abbiyesuku, I. Aliyu, A. Randawa, R. Adamu, S. Adamu, S. Akuyam, M. Manu, H. Suleiman, R. Yusuf, A. Mohammed","doi":"10.4103/0331-3131.177949","DOIUrl":"https://doi.org/10.4103/0331-3131.177949","url":null,"abstract":"Background: Thyroid disorders are the second most common endocrine disorders found during pregnancy. Normal maternal thyroid function is critical for normal fetal development. Gestational thyroid dysfunctions complicate pregnancy with a significant increase in maternal and perinatal morbidity and mortality. Objective: To assess the prevalence of thyroid disorders among pregnant women in Zaria. Materials and Methods: Study population consisted of 300 apparently healthy pregnant women and 100 apparently healthy age-matched nonpregnant controls. Participants were not on any drug that can affect thyroid function. Serum thyroid hormones [thyroid stimulating hormone, free triiodothyronine (T 3 ), free thyroxine (T 4 ), and thyroid peroxidase (TPO) antibody] were assayed using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using Epi Info 3.5.3 and P-values ≤0.05 were considered statistically significant. Results: Ages (mean ± SD) were 25.41 ± 5.98 and 26.70 ± 5.83 years for pregnant women and controls, respectively. Parity mean ± SD were 2.32 ± 2.24 and 2.63 ± 2.75 for pregnant women and controls, respectively. The mean gestational age ± SD was 21.68 ± 10.38 weeks. Three percent (3%) were hypothyroid, while 2.3% were hyperthyroid. Nine percent (9%) were TPO antibody positive. Conclusion: Prevalence of thyroid disorders among pregnant women in Zaria was high therefore routine screening of all pregnant women for thyroid disorders during antenatal care visits may be of benefit.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"520 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116206385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.4103/0331-3131.177944
Suryakant Deogade, S. Ghate, G. Dube, Sumathi K Nitin, P. Dube, Utkarsh Katare, Divya Katare, Shreyansh Damade
Recent discoveries in the field of stem cells place dental professionals at the forefront of helping their patients with potentially life-saving therapies derived from a patient′s own stem cells obtained from deciduous or permanent teeth. Stem cells have opened doors of great hope in that these cells produced in large quantities through cell cultures could be injected into failing tissues and organs, which would replace these damaged cells with fresh ones. The emerging field of personalized medicine has focused on the ability of stem cells to grow and regenerate tissues using a patient′s own stem cells for biologically compatible therapies and individually tailored treatments. This review discusses the information available on the different types of dental stem cells (DSCs) and their potential role in both dental and medical regenerative therapies.
{"title":"Application of dental stem cells in regenerative medicine","authors":"Suryakant Deogade, S. Ghate, G. Dube, Sumathi K Nitin, P. Dube, Utkarsh Katare, Divya Katare, Shreyansh Damade","doi":"10.4103/0331-3131.177944","DOIUrl":"https://doi.org/10.4103/0331-3131.177944","url":null,"abstract":"Recent discoveries in the field of stem cells place dental professionals at the forefront of helping their patients with potentially life-saving therapies derived from a patient′s own stem cells obtained from deciduous or permanent teeth. Stem cells have opened doors of great hope in that these cells produced in large quantities through cell cultures could be injected into failing tissues and organs, which would replace these damaged cells with fresh ones. The emerging field of personalized medicine has focused on the ability of stem cells to grow and regenerate tissues using a patient′s own stem cells for biologically compatible therapies and individually tailored treatments. This review discusses the information available on the different types of dental stem cells (DSCs) and their potential role in both dental and medical regenerative therapies.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116214369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153363
F. Ejagwulu, A. Ibrahim
Symmetrical peripheral gangrene (SPG) is a rare syndrome. It is characterized by bilateral distal ischemia leading to gangrene, in the absence of major vascular occlusive disease. It is considered a cutaneous marker of disseminated intravascular coagulation, and more than half of the patients who survive require amputation of the affected limb(s). The etio-pathogenesis of SPG is not well understood, but the hallmark is the occurrence of microcirculatory failure. We present two patients with SPG. The aim of this report is to sensitize and to help make the diagnosis easier for the clinician. Patients who are identified to be at risk require frequent observation and examination of the appearance of their distal extremities, nose, and ears. No treatment is universally effective. It should be individualized according to the underlying disease and patient′s general condition. The guiding principle is prompt identification and reduction or removal of aggravating factors.
{"title":"Symmetrical peripheral gangrene and extremity amputations","authors":"F. Ejagwulu, A. Ibrahim","doi":"10.4103/0331-3131.153363","DOIUrl":"https://doi.org/10.4103/0331-3131.153363","url":null,"abstract":"Symmetrical peripheral gangrene (SPG) is a rare syndrome. It is characterized by bilateral distal ischemia leading to gangrene, in the absence of major vascular occlusive disease. It is considered a cutaneous marker of disseminated intravascular coagulation, and more than half of the patients who survive require amputation of the affected limb(s). The etio-pathogenesis of SPG is not well understood, but the hallmark is the occurrence of microcirculatory failure. We present two patients with SPG. The aim of this report is to sensitize and to help make the diagnosis easier for the clinician. Patients who are identified to be at risk require frequent observation and examination of the appearance of their distal extremities, nose, and ears. No treatment is universally effective. It should be individualized according to the underlying disease and patient′s general condition. The guiding principle is prompt identification and reduction or removal of aggravating factors.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123372898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153361
O. O. Olatunji
Background: Endotracheal intubation is one of the most important anaesthetic skills. Endotracheal intubation in patients with limited mouth opening always remains a challenge, especially in the absence of a flexible fiber-optic bronchoscope. The retrograde catheter technique is an acceptable option for airway management in cases where oral intubation is not possible because of limited mouth opening, or is not recommended because of fear of dislodgement of fracture segments of facial bones. We performed retrograde intubation in a complicated bilateral mandibular fracture from a gunshot injury.
{"title":"Retrograde intubation in a complicated bilateral mandibular fracture from gunshot injury","authors":"O. O. Olatunji","doi":"10.4103/0331-3131.153361","DOIUrl":"https://doi.org/10.4103/0331-3131.153361","url":null,"abstract":"Background: Endotracheal intubation is one of the most important anaesthetic skills. Endotracheal intubation in patients with limited mouth opening always remains a challenge, especially in the absence of a flexible fiber-optic bronchoscope. The retrograde catheter technique is an acceptable option for airway management in cases where oral intubation is not possible because of limited mouth opening, or is not recommended because of fear of dislodgement of fracture segments of facial bones. We performed retrograde intubation in a complicated bilateral mandibular fracture from a gunshot injury.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114259274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153362
V. Shidali, Mukhtar Abdulmajid Adeiza
Primary pulmonary fibrosarcomas are rare malignant tumors of mesenchymal origin. We report a case of primary pulmonary fibrosarcoma in a 35-year-old man who presented with chronic cough and progressive breathlessness. Further clinical evaluation revealed a right lung mass extending from the base of the lung to the mid zone. Histology of biopsied sections of the mass confirmed a lung fibrosarcoma thought to be primary in view of the absence of any other source. Outcome was however unfavorable due to death of the patient. Late presentation and the extensive nature of the disease were identified as the cause of mortality. This case is reported because of its rarity.
{"title":"Primary pulmonary fibrosarcoma: A case report from a Teaching Hospital in Northern Nigeria","authors":"V. Shidali, Mukhtar Abdulmajid Adeiza","doi":"10.4103/0331-3131.153362","DOIUrl":"https://doi.org/10.4103/0331-3131.153362","url":null,"abstract":"Primary pulmonary fibrosarcomas are rare malignant tumors of mesenchymal origin. We report a case of primary pulmonary fibrosarcoma in a 35-year-old man who presented with chronic cough and progressive breathlessness. Further clinical evaluation revealed a right lung mass extending from the base of the lung to the mid zone. Histology of biopsied sections of the mass confirmed a lung fibrosarcoma thought to be primary in view of the absence of any other source. Outcome was however unfavorable due to death of the patient. Late presentation and the extensive nature of the disease were identified as the cause of mortality. This case is reported because of its rarity.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126620687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153356
A. Sakajiki, B. Adamu, F. Arogundade, A. Abdu, A. Atanda, B. I. Garba
Background: Renal disease in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) contributes significantly to morbidity and mortality associated with HIV infection worldwide. Aim: To determine the prevalence, risk factors, and histological pattern of kidney disease in HIV-positive patients in Kano, Nigeria. Materials and Methods: Four hundred consecutive treatment naοve HIV-positive patients with no other condition known to cause kidney disease were screened for proteinuria and reduced glomerular filtration rate (GFR). Kidney disease was defined as the presence of persistent microalbuminuria/proteinuria or decreased GFR (<60 ml/min/1.73 m 2 ). Kidney biopsy was performed on 20 patients. Data were analyzed using SPSS version 17. Results: The mean ± standard deviation age of the study population was 34.03 ± 10.23 years with 240 (60%) being females. Kidney disease was found in 227 patients (56.8%), with a higher prevalence seen in males (odds ratio = 1.9305, 95% confidence interval = 1.2760-2.9207, P = 0.0018). Proteinuria including persistent microalbuminuria was found in 211 (52.8%) and reduced GFR was found in 64 (16.0%). The risk factors for developing kidney disease were age >40 years, male gender, low CD4 cell count, cigarette smoking, low body mass index, and low serum cholesterol. Logistic regression identified low CD4 cell count as an independent risk factor for kidney disease. Collapsing focal segmental glomerulosclerosis (FSGS) was the predominant histological pattern seen. Conclusion: The prevalence of renal disease in HIV-positive patients was high in Kano, Nigeria; and microalbuminuria was a manifestation of collapsing FSGS.
{"title":"Prevalence, risk factors, and histological pattern of kidney disease in patients with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome at Aminu Kano Teaching Hospital: A clinicopathologic study","authors":"A. Sakajiki, B. Adamu, F. Arogundade, A. Abdu, A. Atanda, B. I. Garba","doi":"10.4103/0331-3131.153356","DOIUrl":"https://doi.org/10.4103/0331-3131.153356","url":null,"abstract":"Background: Renal disease in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) contributes significantly to morbidity and mortality associated with HIV infection worldwide. Aim: To determine the prevalence, risk factors, and histological pattern of kidney disease in HIV-positive patients in Kano, Nigeria. Materials and Methods: Four hundred consecutive treatment naοve HIV-positive patients with no other condition known to cause kidney disease were screened for proteinuria and reduced glomerular filtration rate (GFR). Kidney disease was defined as the presence of persistent microalbuminuria/proteinuria or decreased GFR (<60 ml/min/1.73 m 2 ). Kidney biopsy was performed on 20 patients. Data were analyzed using SPSS version 17. Results: The mean ± standard deviation age of the study population was 34.03 ± 10.23 years with 240 (60%) being females. Kidney disease was found in 227 patients (56.8%), with a higher prevalence seen in males (odds ratio = 1.9305, 95% confidence interval = 1.2760-2.9207, P = 0.0018). Proteinuria including persistent microalbuminuria was found in 211 (52.8%) and reduced GFR was found in 64 (16.0%). The risk factors for developing kidney disease were age >40 years, male gender, low CD4 cell count, cigarette smoking, low body mass index, and low serum cholesterol. Logistic regression identified low CD4 cell count as an independent risk factor for kidney disease. Collapsing focal segmental glomerulosclerosis (FSGS) was the predominant histological pattern seen. Conclusion: The prevalence of renal disease in HIV-positive patients was high in Kano, Nigeria; and microalbuminuria was a manifestation of collapsing FSGS.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125956059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153353
D. Irabor
Colorectal cancer (CRC) in Nigeria used to be a rare disease. However, over the last 40 years it has gradually become a significant health concern. Several publications on this disease from Nigeria have documented an increase in the incidence. To suggest possible and credible pathogenesis for the observed increase in CRC incidence in Nigeria, a search through AJOL, PubMed, and Google Scholar using search items like "colon cancer in Nigeria," "rectal cancer in Nigeria," and "CRC in Nigeria" was carried out. Also, a search for known risk factors in the development of CRC such as diet, carcinogens in red meat, alcohol, and polyposis coli syndromes were also initiated. Factors responsible for the increase in CRC incidence in Nigeria include poor refrigeration facilities resulting from poor electricity services; leading to deep-fried, smoked and charcoal-grilled meat. Other risk factors include an affinity for consumption of offal, an increase in obesity, proliferation of fast food joints, and an increase in alcohol intake. It is unclear how long and large the factors that cause CRC in a patient will have to be present before developing the disease. A dietary intake of fresh, wholesome, non-processed, preservative and hydrocarbon free foods should be encouraged; while habits such as consumption of alcohol and cigarette smoking are discouraged.
{"title":"Diet, environmental factors and increasing incidence of colorectal cancer in Nigeria","authors":"D. Irabor","doi":"10.4103/0331-3131.153353","DOIUrl":"https://doi.org/10.4103/0331-3131.153353","url":null,"abstract":"Colorectal cancer (CRC) in Nigeria used to be a rare disease. However, over the last 40 years it has gradually become a significant health concern. Several publications on this disease from Nigeria have documented an increase in the incidence. To suggest possible and credible pathogenesis for the observed increase in CRC incidence in Nigeria, a search through AJOL, PubMed, and Google Scholar using search items like \"colon cancer in Nigeria,\" \"rectal cancer in Nigeria,\" and \"CRC in Nigeria\" was carried out. Also, a search for known risk factors in the development of CRC such as diet, carcinogens in red meat, alcohol, and polyposis coli syndromes were also initiated. Factors responsible for the increase in CRC incidence in Nigeria include poor refrigeration facilities resulting from poor electricity services; leading to deep-fried, smoked and charcoal-grilled meat. Other risk factors include an affinity for consumption of offal, an increase in obesity, proliferation of fast food joints, and an increase in alcohol intake. It is unclear how long and large the factors that cause CRC in a patient will have to be present before developing the disease. A dietary intake of fresh, wholesome, non-processed, preservative and hydrocarbon free foods should be encouraged; while habits such as consumption of alcohol and cigarette smoking are discouraged.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126907725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153360
K. Uwanuruochi, Sabari Saravanan, Anita Ganasekar, Benjamin Solomon, Ravikumar Murugesan, Jaishankar Krishnamoorthy, U. Pandurangi
Context: Radiofrequency ablation (RFA) is a recognised mode of therapy for cardiac arrhythmias. The procedure is carried our regularly at the Cardiac Catheterization Laboratory of Madras Medical Mission, India. Aim: To evaluate the intermediate term follow-up results of radiofrequency catheter ablations. Subjects and Methods: This was a retrospective study carried out in the Cardiac Electrophysiology Department of the Institute of Cardiovascular Diseases, Madras Medical Mission (MMM), India. Records of consecutive cardiac electrophysiologic studies carried out between January and October 2009, together with records of follow-up to March 2014 for those that underwent RFAs were reviewed. In total, the records of 139 cases that had RFAs were analysed. Results: The 139 patients comprised of 65 males and 74 females. The indication for RFA was drug refractory arrhythmias in the vast majority (137 patients). There was a very high success rate (97.1%), following cardiac ablations. Early complications were observed in only 3 (2.2%) patients. Recurrence rate of the indication for RFA was very low (1.43%), and there was no mortality associated with the procedure. Conclusions: The treatment of patients with cardiac arrhythmias using RFA, was associated with a high rate of success, and low rate of complications.
{"title":"Review of outcome of radiofrequency cardiac catheter ablations carried out at Madras Medical Mission, India","authors":"K. Uwanuruochi, Sabari Saravanan, Anita Ganasekar, Benjamin Solomon, Ravikumar Murugesan, Jaishankar Krishnamoorthy, U. Pandurangi","doi":"10.4103/0331-3131.153360","DOIUrl":"https://doi.org/10.4103/0331-3131.153360","url":null,"abstract":"Context: Radiofrequency ablation (RFA) is a recognised mode of therapy for cardiac arrhythmias. The procedure is carried our regularly at the Cardiac Catheterization Laboratory of Madras Medical Mission, India. Aim: To evaluate the intermediate term follow-up results of radiofrequency catheter ablations. Subjects and Methods: This was a retrospective study carried out in the Cardiac Electrophysiology Department of the Institute of Cardiovascular Diseases, Madras Medical Mission (MMM), India. Records of consecutive cardiac electrophysiologic studies carried out between January and October 2009, together with records of follow-up to March 2014 for those that underwent RFAs were reviewed. In total, the records of 139 cases that had RFAs were analysed. Results: The 139 patients comprised of 65 males and 74 females. The indication for RFA was drug refractory arrhythmias in the vast majority (137 patients). There was a very high success rate (97.1%), following cardiac ablations. Early complications were observed in only 3 (2.2%) patients. Recurrence rate of the indication for RFA was very low (1.43%), and there was no mortality associated with the procedure. Conclusions: The treatment of patients with cardiac arrhythmias using RFA, was associated with a high rate of success, and low rate of complications.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116847505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153354
P. Jorwal, P. Keshwani, R. Verma
Background: Acanthosis nigricans (AN) is a skin condition associated with insulin resistance, and highly correlated with hyperinsulinemia, type 2 diabetes, and obesity; with scarcity of information regarding its status in young adult subjects. Aim: To determine the association between the presence of AN with biochemical parameters and anthropometric variables. Subjects and Methods: This analytical cross-sectional study included young male subjects from outpatient department of Medicine of a tertiary care center in North India. They were divided into three group of 40 subjects each. Group I consisted of subjects having AN, Group II consisted of obese/overweight subjects without AN, and Group III consisted of control subjects without AN or obesity. Covariates included family history of diabetes. Results: There was a significant positive association (P < 0.001) between AN and high body mass index (BMI), fasting glucose, waist-hip ratio (WHR), and systolic blood pressure (BP) even when controlled for obesity. For lipoproteins, insulin, and diastolic BP, the association even though significant, was inconsistent when obesity was taken into consideration. Conclusion: Individuals with AN have lower high-density lipoproteins, and higher BMI, fasting blood glucose (FBG), serum insulin, total cholesterol, triglycerides, low-density lipoproteins, and systolic as well as diastolic pressure. Irrespective of being obese, AN is associated with a high BMI, WHR, FBG and systolic BP in young adults.
{"title":"Association of acanthosis nigricans with anthropometric and biochemical parameters in young Indian males","authors":"P. Jorwal, P. Keshwani, R. Verma","doi":"10.4103/0331-3131.153354","DOIUrl":"https://doi.org/10.4103/0331-3131.153354","url":null,"abstract":"Background: Acanthosis nigricans (AN) is a skin condition associated with insulin resistance, and highly correlated with hyperinsulinemia, type 2 diabetes, and obesity; with scarcity of information regarding its status in young adult subjects. Aim: To determine the association between the presence of AN with biochemical parameters and anthropometric variables. Subjects and Methods: This analytical cross-sectional study included young male subjects from outpatient department of Medicine of a tertiary care center in North India. They were divided into three group of 40 subjects each. Group I consisted of subjects having AN, Group II consisted of obese/overweight subjects without AN, and Group III consisted of control subjects without AN or obesity. Covariates included family history of diabetes. Results: There was a significant positive association (P < 0.001) between AN and high body mass index (BMI), fasting glucose, waist-hip ratio (WHR), and systolic blood pressure (BP) even when controlled for obesity. For lipoproteins, insulin, and diastolic BP, the association even though significant, was inconsistent when obesity was taken into consideration. Conclusion: Individuals with AN have lower high-density lipoproteins, and higher BMI, fasting blood glucose (FBG), serum insulin, total cholesterol, triglycerides, low-density lipoproteins, and systolic as well as diastolic pressure. Irrespective of being obese, AN is associated with a high BMI, WHR, FBG and systolic BP in young adults.","PeriodicalId":331118,"journal":{"name":"Annals of Nigerian Medicine","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133418315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.4103/0331-3131.153352
S. Aliyu
Corresponding Author: Dr. Shamsudin Aliyu, Department of Medical Microbiology, Ahmadu Bello University Teaching Hospital, Shika, Zaria, Kaduna State, Nigeria. E-mail: shamsualiyu@gmail.com The genomic revolution promises to transform the practice of medicine, including the specialty of clinical microbiology. Clinical microbiology is the branch of medicine that is concerned with the laboratory diagnosis, treatment, and prevention of infectious diseases. Clinical microbiology helps to direct the management of infections in individual patients (diagnostic microbiology), and helps to monitor and control the spread of infectious diseases (public health microbiology). Ongoing developments in sequencing technology will have a huge impact on the way clinical microbiologist identify and characterize all pathogens, namely bacteria, viruses, fungi, and parasites. However, because of the burden of infections caused by bacterial pathogens worldwide, this editorial focuses on the impact of whole genome sequencing (WGS) on clinical bacteriology.
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