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HIV/AIDS treatment in sub-Saharan Africa: Towards universal access and universal "test and treat" strategy 撒哈拉以南非洲的艾滋病毒/艾滋病治疗:实现普遍可及和普遍“检测和治疗”战略
Pub Date : 2012-07-01 DOI: 10.4103/0331-3131.108106
Mukhtar Abdulmajid Adeiza
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引用次数: 1
Exhaled nitric oxide in the diagnosis and management of bronchial asthma: From bench to bedside? 呼出一氧化氮在支气管哮喘诊断和治疗中的应用:从实验室到床边?
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92949
A. Abba, Mukhtar Abdulmajid Adeiza
The identification of nitric oxide in exhaled breath and its role as a surrogate marker of eosinophilic inflammation of the airways led to rapid development in the area of its measurement. Standardized measurement techniques have been developed as well as simple, cheap, and reliable equipments. Although a number of factors have been identified as affecting its assay, fractional exhaled nitric oxide (FENO) can reliably be used to distinguish eosinophilic from non-eosinophilic airway inflammation. Unlike the other indirect measures of airway inflammation such as FEV1 reversibility and bronchoprovocative tests, FENO is noninvasive and gives a direct measure of inflammation. There are sufficient data supporting its role in the diagnosis of asthma, monitoring of disease, prediction of relapse, and level of compliance. Measurement of FENO has therefore made the transition from the bench to the bedside. Of recent, there are attempts at devising interpretative strategies for its use in day to day clinical practice.
呼气中一氧化氮的鉴定及其作为气道嗜酸性粒细胞炎症的替代标记物的作用导致其测量领域的快速发展。标准化的测量技术和简单、廉价、可靠的设备得到了发展。虽然已经确定了许多影响其测定的因素,但分数呼出一氧化氮(FENO)可以可靠地用于区分嗜酸性和非嗜酸性气道炎症。与FEV1可逆性和支气管刺激试验等其他气道炎症的间接测量方法不同,FENO是非侵入性的,可以直接测量炎症。有足够的数据支持其在哮喘诊断、疾病监测、复发预测和依从性方面的作用。因此,FENO的测量已经从实验室过渡到床边。最近,有人试图为其在日常临床实践中的使用设计解释策略。
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引用次数: 0
Diagnosis of latent tuberculosis infection: The tuberculin skin test and interferon gamma release assays 潜伏性结核感染的诊断:结核菌素皮肤试验和干扰素释放试验
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92946
Mukhtar Abdulmajid Adeiza
The clinical manifestations of tuberculosis (TB) represent a complex interaction between the causative organism, Mycobacterium tuberculosis, and the human host immune response.[1] TB is the most common cause of infectious disease-related mortality worldwide after the human immunodeficiency virus (HIV). The World Health Organization (WHO) estimates that 2 billion people are infected worldwide, and according to the 2010 global TB report, there were an estimated 9.4 million incident cases of TB with 12% of these occurring in HIV-positive patients.[2] The bulk of this disease burden resides in sub-Saharan Africa and the majorities of these infections are asymptomatic and may reactivate later in life. This huge global reservoir is termed latent tuberculosis infection (LTBI) and constitutes an important source of infection and a continuous source of transmission. The goal of testing for LTBI is to identify individuals who are at increased risk for the development of TB and therefore would benefit from treatment. Currently, there is no available gold standard or confirmatory test for the diagnosis of LTBI and available surrogates are not without limitations with respect to technical issues with test performance, cost, specificity, sensitivity, effect of Bacille Calmette-Guérin (BCG) vaccine, and environmental mycobacteria. LATENT TUBERCULOSIS INFECTION
结核病(TB)的临床表现是病原体结核分枝杆菌与人类宿主免疫反应之间复杂的相互作用。[1]结核病是继人类免疫缺陷病毒(HIV)之后全球最常见的传染病相关死亡原因。世界卫生组织(WHO)估计全世界有20亿人被感染,根据2010年全球结核病报告,估计有940万例结核病病例,其中12%发生在艾滋病毒阳性患者中。[2]这种疾病负担的大部分存在于撒哈拉以南非洲,这些感染中的大多数是无症状的,并可能在以后的生活中重新激活。这一巨大的全球病毒库被称为潜伏结核感染(LTBI),是重要的感染源和持续传播源。LTBI检测的目标是确定结核病发展风险增加的个体,从而从治疗中受益。目前,尚无诊断LTBI的金标准或确认性试验,可用的替代方法在检测性能、成本、特异性、敏感性、卡介苗效果和环境分枝杆菌等技术问题上并非没有限制。潜伏结核感染
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引用次数: 4
Study of blood glucose level in normal and low birth weight newborns and impact of early breast feeding in a tertiary care centre 三级保健中心正常和低出生体重新生儿血糖水平及早期母乳喂养影响的研究
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92951
A. De, R. Biswas, M. Samanta, C. Kundu
Background and Objectives: Neonatal hypoglycemia, a common metabolic problem, often goes unnoticed owing to lack of specific symptoms. We designed this study to assess the incidence of hypoglycemia in healthy normal birth weight and low birth weight babies, including both preterm and small for gestational age (SGA) newborns, to evaluate the impact of early breastfeeding on hypoglycemia and to assess the impact of exclusive breast feeding on glucose values up to 48 h of age. Design and Settings: A hospital-based prospective longitudinal study. Materials and Methods: The study was conducted over six months involving one hundred fifty healthy (both term and preterm) appropriate for gestational age (AGA) or SGA babies with birth weight between 1.5 kg and 3.99 kg. Blood glucose values were measured at the age of 1 h, 6 h, 12 h, 24 h and 48 h after delivery which was independent of feeding time. Blood glucose value less than 40 mg/dl (2.2 mmol/l) was defined as hypoglycemia. Sick newborns, those less than 34 weeks of gestation or less than 1500 g, infant of diabetic mother, those with birth asphyxia, congenital malformations and endocrine deficiencies were excluded. Results: Overall incidence of hypoglycemia was 32%. Hypoglycemia was significantly greater in SGA and preterm as compared to AGA and term newborns respectively (P<0.001). Incidence of hypoglycemia was significantly more in newborns with delayed breast feeding than early breast feeding (64% vs 17%; P<0.001). Conclusion: Low birth weight babies (both preterm and small-for-date) are prone to develop hypoglycemia especially in first 24 h of life with delayed introduction of breast feeding being an additional risk.
背景与目的:新生儿低血糖是一种常见的代谢问题,由于缺乏特异性症状,常常被忽视。本研究旨在评估健康正常出生体重和低出生体重婴儿(包括早产儿和小胎龄新生儿)的低血糖发生率,以评估早期母乳喂养对低血糖的影响,并评估纯母乳喂养对48小时前血糖值的影响。设计与环境:一项基于医院的前瞻性纵向研究。材料和方法:研究进行了六个月,涉及150名健康(足月和早产儿),适合胎龄(AGA)或SGA,出生体重在1.5公斤至3.99公斤之间。分别于分娩后1 h、6 h、12 h、24 h和48 h测定血糖值,与喂养时间无关。血糖值低于40 mg/dl (2.2 mmol/l)为低血糖。排除患病新生儿、妊娠小于34周或小于1500 g、糖尿病母亲的婴儿、出生时窒息、先天性畸形和内分泌缺陷的婴儿。结果:低血糖总发生率为32%。SGA和早产儿的低血糖明显高于AGA和足月新生儿(P<0.001)。延迟母乳喂养的新生儿低血糖发生率明显高于早期母乳喂养的新生儿(64% vs 17%;P < 0.001)。结论:低出生体重婴儿(包括早产儿和小于出生日期的婴儿)容易发生低血糖,特别是在出生后24小时,延迟引入母乳喂养是一个额外的风险。
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引用次数: 34
A case of tuberculous lymphadenitis with erythema nodosum 结核性淋巴结炎伴结节性红斑1例
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92956
S. Acharya, S. Shukla, Amit Gupta, Dinesh Singh, S. Diwan
Sir, Erythema nodosum (EN), a painful disorder of the subcutaneous fat, is the most common type of panniculitis. Generally, it is idiopathic, although the most common identifiable cause is streptococcal pharyngitis. EN may be the first sign of a systemic disease such as tuberculosis (TB), bacterial or deep fungal infection, sarcoidosis, inflammatory bowel disease, or cancer. Certain drugs, including oral contraceptives and some antibiotics, also may be etiologic. We present a case of tubercular lymphadenitis with EN.
结节性红斑(EN)是一种疼痛的皮下脂肪紊乱,是最常见的脂性炎。一般来说,它是特发性的,尽管最常见的可识别的原因是链球菌性咽炎。EN可能是全身性疾病如肺结核(TB)、细菌或深部真菌感染、结节病、炎症性肠病或癌症的第一个征兆。某些药物,包括口服避孕药和一些抗生素,也可能是病因性的。我们报告一例伴有EN的结核性淋巴结炎。
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引用次数: 1
Tuberculosis in the left inguinal region associated with cutaneous tuberculosis of left second toe: An unusual presentation of extrapulmonary tuberculosis 左腹股沟区结核伴左第二趾皮肤结核:肺外结核的不寻常表现
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92952
J. Kar, M. Kar, S. Maiti
We report an uncommon case of tuberculosis involving left second toe associated with left inguinal lymphadenopathy and an ulcer in a 30-year-old male with no other pulmonary or extra pulmonary tubercular infection. Diagnosis was made by biopsy. He responded very well to anti tubercular treatment.
我们报告一个罕见的病例结核累及左第二脚趾与左腹股沟淋巴结病变和溃疡在一个30岁的男性没有其他肺部或肺外结核感染。通过活检进行诊断。他对抗结核治疗反应很好。
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引用次数: 1
Prevalence and determinants of "low birth weight" among institutional deliveries 机构分娩中“低出生体重”的患病率和决定因素
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92950
K. Agarwal, A. Agarwal, Vinita Agrawal, P. Agrawal, V. Chaudhary
Background: Birth weight is an important determinant of child survival and development. It is also a subject of clinical and epidemiological investigations. This study was planned to find out the epidemiological factors associated with low birth weight (LBW) among institutional deliveries so that suitable recommendation can be made to prevent LBW. Objectives: The present study was therefore undertaken to find out some maternal factors that may have their association, if any with LBW. Materials and Methods: This cross-sectional study was carried out at tertiary care hospital among 350 mothers delivering live born neonate in study place. All babies were weighed within 24 hours after the birth. The babies were weighed on beam type weighing machine up to 20 g accuracy. LBW was defined as a birth weight of <2500 gram. All mothers were examined and interviewed within 24 hours after delivery and findings were recorded. The analysis was done using Epi Info package. Results : In this study, 40.0% mothers delivered LBW babies. Findings indicate that gestational age less than 37 weeks (76.5%), maternal age less than 20 years (58.5%), irregular antenatal checkup (70.5%), mother′s height less than 150 cm (68.5%), mother′s weight less than 50 kg (76.1%), hemoglobin less than 10 gm/dl (60.5%), severe physical work (78%), and tobacco chewing (58.5%) are significant determinants of LBW. Conclusion: Our study indicates that gestational age, maternal age, regular antenatal checkup, mother′s height, mother′s weight, anemia, physical work, and tobacco chewing are significant determinants of LBW. Prevalence of LBW can be reduced by increasing the gestational age, regular antenatal checkup, balanced diet during antenatal period, adequate rest during antenatal period, and avoiding the tobacco chewing.
背景:出生体重是儿童生存和发展的重要决定因素。它也是临床和流行病学调查的主题。本研究旨在了解与医院分娩低出生体重相关的流行病学因素,为预防低出生体重提出合适的建议。目的:因此,本研究旨在找出一些可能与LBW有关的母系因素。材料与方法:本横断面研究在三级医院进行,研究对象为350名分娩活产新生儿的母亲。所有婴儿都在出生后24小时内称重。婴儿在精确20克的横梁式称重机上称重。LBW定义为出生体重<2500克。所有母亲在分娩后24小时内接受检查和访谈,并记录调查结果。使用Epi Info软件包进行分析。结果:在本研究中,40.0%的母亲生下了LBW婴儿。结果显示,孕周小于37周(76.5%)、母亲年龄小于20岁(58.5%)、产前检查不规律(70.5%)、母亲身高小于150 cm(68.5%)、母亲体重小于50 kg(76.1%)、血红蛋白小于10 gm/dl(60.5%)、剧烈体力劳动(78%)和咀嚼烟草(58.5%)是影响新生儿低体重的重要因素。结论:本研究提示胎龄、母亲年龄、定期产前检查、母亲身高、体重、贫血、体力劳动和烟草咀嚼是影响LBW的重要因素。可通过增加胎龄、定期产前检查、孕期均衡饮食、孕期充分休息和避免咀嚼烟草等措施降低低体重儿的患病率。
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引用次数: 67
Amyand′s hernia: A rare occurrence Amyand疝气:罕见
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92955
T. Khan, M. Wani, A. Bijli, S. Wani, Nayeem-ul-hassan, I. Irshad, N. Shaheen, H. Khan
Claudius Amyand, Surgeon to King George II, was the first to describe the presence of a perforated appendix within the hernial sac (in 1735) of an 11-year-old boy who had undergone successful appendicectomy. Amyand′s hernia is an inguinal hernia with an appendix involved. It is a rare condition. The chance finding of the vermiform appendix lying within an inguinal hernia occurs in approximately one percent of cases of inguinal hernia. Preoperative diagnosis is difficult. If additional pathologies exist, the diagnosis is more troublesome. We aimed to present a patient with Amyand′s hernia which is rare in the literature
1735年,乔治二世国王的外科医生Claudius Amyand首次描述了一名成功切除阑尾的11岁男孩在疝囊内出现阑尾穿孔。Amyand疝是一种累及阑尾的腹股沟疝。这是一种罕见的疾病。在腹股沟疝中发现蚓状阑尾的几率约为1%。术前诊断困难。如果存在其他病理,诊断就比较麻烦。我们的目的是提出一个病人与Amyand的疝气,这是罕见的文献
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引用次数: 2
Epstein-Barr virus and associated head and neck manifestations 爱泼斯坦-巴尔病毒及其相关的头颈部表现
Pub Date : 2011-07-01 DOI: 10.4103/0331-3131.92947
Nitul Jain, Vishwas Bhatia, Sohail Lattoo
The Epstein-Barr virus (EBV), also called human herpes virus 4, is a virus of the herpes family, having linear double-stranded DNA as its genome. It is best known as the cause of infectious mononucleosis. Besides this, EBV is also associated with particular forms of malignancy, particularly Hodgkin′s lymphoma, Burkitt′s lymphoma, and nasopharyngeal carcinoma, all of which may show their prime manifestations in head and neck area, for which patient may seek a dentist referral initially. In addition, EBV is linked with oral hairy leukoplakia, which may be an earliest oral manifestation of HIV infection. This review article primarily deals with clinical manifestations of diseases associated with EBV infection particularly in head and neck area.
爱泼斯坦-巴尔病毒(EBV),也称为人类疱疹病毒4号,是疱疹家族的一种病毒,其基因组为线性双链DNA。它被认为是传染性单核细胞增多症的病因。除此之外,EBV还与特定形式的恶性肿瘤有关,特别是霍奇金淋巴瘤、伯基特淋巴瘤和鼻咽癌,所有这些肿瘤的主要表现都可能在头颈部,患者可能首先寻求牙医转诊。此外,EBV与口腔毛状白斑有关,这可能是HIV感染的最早口腔表现。本文综述了EBV感染的临床表现,特别是头颈部感染。
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引用次数: 6
Profile of refractive errors and presbyopia in a university community: A clinical study 大学社区屈光不正和老花眼的临床研究
Pub Date : 2010-07-01 DOI: 10.4103/0331-3131.78273
E. Abah, D. Chinda, E. Samaila, E. Anyebe
Aim : To determine the prevalence and distribution of refractive errors and presbyopia in the university community. Materials and Methods : A prospective study of all consecutive patients who visited A.B.U. Sick Bay between March 2009 and May 2010 was conducted. The ophthalmic nurse booked all patients whose visual acuity improved with the use of pinhole for further examination and refraction by one of two ophthalmologists who visited the facility twice a week. Those who did not turn up for refraction were excluded. Results : A total of 1448 patients with mean age of 24.6 SD± 4.9 years, distributed along gender and occupational lines, were seen within the study period. The prevalence of refractive errors and presbyopia was 15.8%. The prevalence of refractive error alone in the sample population was 9.5%, that of presbyopia only was 4.2% and that of those who had both refractive error and presbyopia was 2.1% (i.e. total prevalence of refractive errors = 11.6%). However, the total prevalence of presbyopia among those above 40 years was 49.7%. The predominant errors were astigmatism and simple myopia. Conclusion : Presbyopia and refractive errors, especially astigmatism and simple myopia, are common eye conditions in the university environment. Many patients would not turn up for their refraction appointments. It is recommended that mass enlightenment and screening for refractive errors be commenced, while routine assessment of new students and staff will also help to curb the negative impact on academic performance.
目的:了解大学生屈光不正和老花眼的患病率及分布。材料和方法:对2009年3月至2010年5月期间到访A.B.U.医务室的所有连续患者进行前瞻性研究。眼科护士预约了所有使用针孔视力改善的患者,由两名眼科医生中的一名进行进一步检查和验光,这些眼科医生每周来两次。那些没有参加折射检查的人被排除在外。结果:研究期间共观察到1448例患者,平均年龄24.6 SD±4.9岁,按性别和职业分布。屈光不正和老花的发生率为15.8%。样本人群中屈光不正的患病率为9.5%,老花眼的患病率为4.2%,同时存在屈光不正和老花眼的患病率为2.1%(即屈光不正总患病率= 11.6%)。然而,40岁以上人群中老花的总患病率为49.7%。主要的误差是散光和单纯性近视。结论:老花眼和屈光不正,尤其是散光和单纯性近视是大学环境中常见的眼病。许多患者不愿赴约进行屈光检查。我们建议开展大规模的启蒙和屈光不正筛查,同时对新生和教职员进行常规评估,也有助于遏制对学习成绩的负面影响。
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引用次数: 6
期刊
Annals of Nigerian Medicine
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