Pub Date : 2024-03-28DOI: 10.18502/ijdo.v16i1.15239
Samira Kashani, Zahra Hesari, Faramarz Koohsar, K. Kalavi, M. Hojjati
Objective: For many years HbA1c used as diagnostic criteria for diabetes, however, measurement of HbA1 has some limitations that cannot be accurately assess blood glucose levels in conditions such as changes in red blood cell life. in this study, we evaluated and compared the levels of HbA1C in diabetic, pre-diabetic and non- diabetic individuals to understand the role and relationship of different values of RBC`s indices in these conditions. Materials and Methods: This study performed between august to December of year 2021, and the demographic information and hematologic indices of 706 individuals which referred to laboratories in Gorgan city were investigated. According to results of FBS and HbA1c, individuals categorized in three distinct healthy (H), pre-diabetic (PD), and diabetic (D) groups base on latest ADA criteria. Results: Evaluation of HbA1c level based on the presence or absence of anemia showed that in diabetic group with anemia significantly had a lower level 8.4 (± 1.5) than people without anemia 8.6 (± 1.5) (P= 0.045). Conclusion: In this study, it was shown that changes in RBC indices in anemia can lead to inaccurate measurement of HbA1c level.
{"title":"Evaluation of Anemia Effect on HbA1c Level Measurement in Type 2 Diabetic People","authors":"Samira Kashani, Zahra Hesari, Faramarz Koohsar, K. Kalavi, M. Hojjati","doi":"10.18502/ijdo.v16i1.15239","DOIUrl":"https://doi.org/10.18502/ijdo.v16i1.15239","url":null,"abstract":"\u0000 \u0000 \u0000Objective: For many years HbA1c used as diagnostic criteria for diabetes, however, measurement of HbA1 has some limitations that cannot be accurately assess blood glucose levels in conditions such as changes in red blood cell life. in this study, we evaluated and compared the levels of HbA1C in diabetic, pre-diabetic and non- diabetic individuals to understand the role and relationship of different values of RBC`s indices in these conditions. \u0000Materials and Methods: This study performed between august to December of year 2021, and the demographic information and hematologic indices of 706 individuals which referred to laboratories in Gorgan city were investigated. According to results of FBS and HbA1c, individuals categorized in three distinct healthy (H), pre-diabetic (PD), and diabetic (D) groups base on latest ADA criteria. \u0000Results: Evaluation of HbA1c level based on the presence or absence of anemia showed that in diabetic group with anemia significantly had a lower level 8.4 (± 1.5) than people without anemia 8.6 (± 1.5) (P= 0.045). Conclusion: In this study, it was shown that changes in RBC indices in anemia can lead to inaccurate measurement of HbA1c level. \u0000 \u0000 \u0000","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"102 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Circulating endothelial progenitor cells (EPCs) play an essential role in endothelial repair and neovascularization. Vitamin D deficiency may contribute to EPC depletion and endothelial dysfunction in patients with type 2 diabetes. In addition, iron overload is closely related to the development of diabetes and its various chronic complications. This study was designed to determine the relationship between EPC markers (CD34, CD133), vitamin D, and iron in patients with diabetic nephropathy. Materials and Methods: This case-control study was conducted on 67 diabetic patients with or without nephropathy. Blood pressure and all biochemical parameters were measured and compared. Serum concentrations of insulin, vitamin D, CD34, and CD133 were measured using ELISA. Serum iron concentration was measured using atomic absorption spectrometry. Results: Body mass index (P= 0.006), diastolic pressure (P= 0.018), insulin level (P= 0.028), Creatinine (P= 0.013), duration of diabetes, uric acid, and glomerular filtration rate (GFR) were significantly different between the two groups (each P= 0.0001).The vitamin D (P= 0.034), CD34 (P= 0.0001), and CD133 (P= 0.025) levels decreased, and Iron (P= 0.0001) increased in the case group. Also, CD34 has a significant direct relationship with insulin, insulin resistance, and CD133. The results showed that vitamin D, iron, CD34, and CD133 had a significant relationship with the severity of nephropathy (P= 0.0001, each). Conclusion: Increased iron levels and decreased vitamin D, CD34, and CD133 levels are associated with the severity of nephropathy. This result indicates that diabetic nephropathy may directly reduce CD34 and CD133 levels in the body, increasing the incidence of secondary complications in these patients.
{"title":"Correlation between Circulating Endothelial Progenitor Cell Markers, Vitamin D, and Iron Levels in Diabetic Nephropathy","authors":"Vahid Pouresmaeil, Moslem Jasem, Mostafa Maktoof, Tayebeh Rabani Nia, Masoud Homayouni Tabrizi","doi":"10.18502/ijdo.v16i1.15240","DOIUrl":"https://doi.org/10.18502/ijdo.v16i1.15240","url":null,"abstract":"\u0000 \u0000 \u0000Objective: Circulating endothelial progenitor cells (EPCs) play an essential role in endothelial repair and neovascularization. Vitamin D deficiency may contribute to EPC depletion and endothelial dysfunction in patients with type 2 diabetes. In addition, iron overload is closely related to the development of diabetes and its various chronic complications. This study was designed to determine the relationship between EPC markers (CD34, CD133), vitamin D, and iron in patients with diabetic nephropathy. \u0000Materials and Methods: This case-control study was conducted on 67 diabetic patients with or without nephropathy. Blood pressure and all biochemical parameters were measured and compared. Serum concentrations of insulin, vitamin D, CD34, and CD133 were measured using ELISA. Serum iron concentration was measured using atomic absorption spectrometry. \u0000Results: Body mass index (P= 0.006), diastolic pressure (P= 0.018), insulin level (P= 0.028), Creatinine (P= 0.013), duration of diabetes, uric acid, and glomerular filtration rate (GFR) were significantly different between the two groups (each P= 0.0001).The vitamin D (P= 0.034), CD34 (P= 0.0001), and CD133 (P= 0.025) levels decreased, and Iron (P= 0.0001) increased in the case group. Also, CD34 has a significant direct relationship with insulin, insulin resistance, and CD133. The results showed that vitamin D, iron, CD34, and CD133 had a significant relationship with the severity of nephropathy (P= 0.0001, each). \u0000Conclusion: Increased iron levels and decreased vitamin D, CD34, and CD133 levels are associated with the severity of nephropathy. This result indicates that diabetic nephropathy may directly reduce CD34 and CD133 levels in the body, increasing the incidence of secondary complications in these patients. \u0000 \u0000 \u0000","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"33 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.18502/ijdo.v16i1.15241
Alireza Pakgohar, H. Mehrannia
Objective: This review aims to address the critical role of sample size calculation in designing and conducting animal studies related to diabetes and obesity, particularly focusing on experimental comparison methods like ANOV A design. Materials and Methods: We discuss the factors influencing sample size decisions, including type I and type II errors, effect size, and standard deviation. We emphasize the importance of avoiding common pitfalls, such as using rules of thumb or arbitrary choices, and advocate for utilizing established formulas to ensure accurate and reliable sample size determination. Results: This review presents relevant equations for calculating sample size in animal studies with an ANOV A design, providing researchers with a framework for determining the appropriate number of animals needed to achieve robust and ethical research. Conclusion: Accurate sample size calculation is essential for achieving powerful and statistically sound animal studies in diabetes and obesity research. Utilizing established formulas and avoiding arbitrary choices ensures reliable and ethical research practices while minimizing resource waste and maximizing the validity of collected data.
目的：本综述旨在探讨样本量计算在设计和开展与糖尿病和肥胖症有关的动物研究中的关键作用，尤其侧重于方差分析等实验比较方法。材料与方法：我们讨论了影响样本量决策的因素，包括 I 型和 II 型误差、效应大小和标准偏差。我们强调了避免使用经验法则或任意选择等常见误区的重要性，并提倡使用既定公式来确保样本量确定的准确性和可靠性。结果：本综述介绍了在采用方差分析设计的动物研究中计算样本量的相关公式，为研究人员提供了一个框架，用于确定实现稳健和道德研究所需的适当动物数量。结论在糖尿病和肥胖症研究中，准确计算样本量对于开展有说服力且统计合理的动物研究至关重要。利用既定公式，避免随意选择，可确保研究实践可靠、符合伦理，同时最大限度地减少资源浪费，并最大限度地提高所收集数据的有效性。
{"title":"Sample Size Calculation in Clinical Trial and Animal Studies","authors":"Alireza Pakgohar, H. Mehrannia","doi":"10.18502/ijdo.v16i1.15241","DOIUrl":"https://doi.org/10.18502/ijdo.v16i1.15241","url":null,"abstract":"\u0000 \u0000 \u0000Objective: This review aims to address the critical role of sample size calculation in designing and conducting animal studies related to diabetes and obesity, particularly focusing on experimental comparison methods like ANOV A design. \u0000Materials and Methods: We discuss the factors influencing sample size decisions, including type I and type II errors, effect size, and standard deviation. We emphasize the importance of avoiding common pitfalls, such as using rules of thumb or arbitrary choices, and advocate for utilizing established formulas to ensure accurate and reliable sample size determination. \u0000Results: This review presents relevant equations for calculating sample size in animal studies with an ANOV A design, providing researchers with a framework for determining the appropriate number of animals needed to achieve robust and ethical research. \u0000Conclusion: Accurate sample size calculation is essential for achieving powerful and statistically sound animal studies in diabetes and obesity research. Utilizing established formulas and avoiding arbitrary choices ensures reliable and ethical research practices while minimizing resource waste and maximizing the validity of collected data. \u0000 \u0000 \u0000","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.18502/ijdo.v16i1.15242
Fateme Reysy, Fateme Bokaee, Tayebeh Roghani, Grace O’Malley, Najimeh Tarkesh Esfahani, M. H. Beni, Roya Kelishadi
Objective: Obesity is a major public health concern. Since the prevalence of obesity is increasing, exploring the impacts of obesity on the developing musculoskeletal system is important. The aim of this study was to compare postural balance, muscle force, and spinal posture between children and adolescents with and without obesity. Materials and Methods: This is a case-control study on 90 children and adolescents with and without obesity (N=45 in each group). Outcome measures will be postural balance, muscle force, and spinal posture. These outcome measures will be compared between groups. Results: Evaluation of HbA1c level based on the presence or absence of anemia showed that in diabetic group with anemia significantly had a lower level 8.4 (± 1.5) than people without anemia 8.6 (± 1.5) (P= 0.045). Conclusion: The findings can determine the importance of assessing musculoskeletal health in children and adolescents with obesity.
{"title":"Comparison of Postural Balance, Muscle Force and Spinal Posture in Obese Children and Adolescents- A Protocol Study","authors":"Fateme Reysy, Fateme Bokaee, Tayebeh Roghani, Grace O’Malley, Najimeh Tarkesh Esfahani, M. H. Beni, Roya Kelishadi","doi":"10.18502/ijdo.v16i1.15242","DOIUrl":"https://doi.org/10.18502/ijdo.v16i1.15242","url":null,"abstract":"\u0000 \u0000 \u0000Objective: Obesity is a major public health concern. Since the prevalence of obesity is increasing, exploring the impacts of obesity on the developing musculoskeletal system is important. The aim of this study was to compare postural balance, muscle force, and spinal posture between children and adolescents with and without obesity. \u0000Materials and Methods: This is a case-control study on 90 children and adolescents with and without obesity (N=45 in each group). Outcome measures will be postural balance, muscle force, and spinal posture. These outcome measures will be compared between groups. \u0000Results: Evaluation of HbA1c level based on the presence or absence of anemia showed that in diabetic group with anemia significantly had a lower level 8.4 (± 1.5) than people without anemia 8.6 (± 1.5) (P= 0.045). Conclusion: The findings can determine the importance of assessing musculoskeletal health in children and adolescents with obesity. \u0000 \u0000 \u0000","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"23 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Adipose tissue-derived adipokines affect cardiometabolic health. This study aimed to evaluate the effect of interval resistance training with different intensities on leptin, adiponectin, and acrosin levels in obese males. Materials and Methods: Fourty-four obese males (27.70± 3.02 years) were randomly allocated into four groups: high intensity (HI), moderate intensity (MI), low intensity (LI), and control (C). Subjects of the HI, MI, and LI groups implemented the training program for 12 weeks, three sessions a week with intensities corresponding 80% 1RM, 60% 1RM, and 40% 1RM,, respectively. Body composition and plasma levels of leptin, adiponectin, and asprosin were evaluated before and after interval resistance training at different intensities. Results: Following exercise, serum levels of leptin and asporin were significantly reduced in all groups (P< 0.01). The greatest reduction of leptin and asporin levels was recorded in the HI group (P= 0.001, P= 0.01) for leptin and asporsin levels, respectively. The level of adiponectin significantly decreased after exercise in all groups (P< 0.001, F= 12.44). The greatest reduction was observed in the HI group compared with the MI and UI group (P= 0.001). Conclusion: Interval resistance training with different intensities can cause significant changes in leptin, asprosin, and adiponectin levels in obese men, and this improvement was better at high intensities.
{"title":"Effect of Interval Resistance Training with Different Intensities on Some Selected Adipokines in Obese Men","authors":"Ensieh Yazdkhasti, Farnaz Seifi Skishahr, Reza Farzizadeh","doi":"10.18502/ijdo.v15i4.14554","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14554","url":null,"abstract":"Objective: Adipose tissue-derived adipokines affect cardiometabolic health. This study aimed to evaluate the effect of interval resistance training with different intensities on leptin, adiponectin, and acrosin levels in obese males. Materials and Methods: Fourty-four obese males (27.70± 3.02 years) were randomly allocated into four groups: high intensity (HI), moderate intensity (MI), low intensity (LI), and control (C). Subjects of the HI, MI, and LI groups implemented the training program for 12 weeks, three sessions a week with intensities corresponding 80% 1RM, 60% 1RM, and 40% 1RM,, respectively. Body composition and plasma levels of leptin, adiponectin, and asprosin were evaluated before and after interval resistance training at different intensities. Results: Following exercise, serum levels of leptin and asporin were significantly reduced in all groups (P< 0.01). The greatest reduction of leptin and asporin levels was recorded in the HI group (P= 0.001, P= 0.01) for leptin and asporsin levels, respectively. The level of adiponectin significantly decreased after exercise in all groups (P< 0.001, F= 12.44). The greatest reduction was observed in the HI group compared with the MI and UI group (P= 0.001). Conclusion: Interval resistance training with different intensities can cause significant changes in leptin, asprosin, and adiponectin levels in obese men, and this improvement was better at high intensities.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"54 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18502/ijdo.v15i4.14553
Mehdi Behkar, M. Eizadi, Saeid Sedaghaty, Yaser Kazemzadeh, Motahareh Moslehi
Objective: Apart from hormonal factors and oxidative stress, insulin synthesis is strongly dependent on transcription factors in the pancreas. The aim of the present study was to assess the impact of high-intensity interval training (HIIT) on genes affecting insulin synthesis in diabetic obese rats. Materials and Methods: Type 2 diabetes (T2D) was induced by a 6-week high-fat diet (HFD) and intraperitoneal injection of streptozotocin (25 mg /kg) in 14 male Wistar rats (10 week old, 220±10 g). Rats with fasting glucose levels between 400 and 150 were considered T2D. The diabetic rats were randomly assigned to exercise (HIIT: 6 weeks/5 sessions weekly, n= 7) or control (n= 7) groups. Forty-eight hours after the intervention, fasting GLP-1R and PKBα gene expression in pancreatic tissue and plasma insulin and glucose levels were compared between the groups. Data were compared by independent t-test used to compare variables, version 22 between groups. A P< 0.05 was considered significant. Results: HIIT led to significant increase in PKBα gene expression (P: 0.001) and insulin (P: 0.031) and decreases in glucose concentration (P: 0.001) compared with the control group. No change was observed in the GLP-1R gene expression response to HIIT (P: 0.093). Conclusion: HIIT is associated with increased serum insulin levels in T2D obese rats. Despite no change in GLP-1R, this improvement is probably rooted in increased expression PKBα in pancreas in response to this type of exercise training
{"title":"Impact of High-Intensity Interval Training on GLP-1R/ PKBα Axis in Pancreatic Tissue of Diabetes Rats Induced by High-Fat Diet and STZ","authors":"Mehdi Behkar, M. Eizadi, Saeid Sedaghaty, Yaser Kazemzadeh, Motahareh Moslehi","doi":"10.18502/ijdo.v15i4.14553","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14553","url":null,"abstract":"Objective: Apart from hormonal factors and oxidative stress, insulin synthesis is strongly dependent on transcription factors in the pancreas. The aim of the present study was to assess the impact of high-intensity interval training (HIIT) on genes affecting insulin synthesis in diabetic obese rats. Materials and Methods: Type 2 diabetes (T2D) was induced by a 6-week high-fat diet (HFD) and intraperitoneal injection of streptozotocin (25 mg /kg) in 14 male Wistar rats (10 week old, 220±10 g). Rats with fasting glucose levels between 400 and 150 were considered T2D. The diabetic rats were randomly assigned to exercise (HIIT: 6 weeks/5 sessions weekly, n= 7) or control (n= 7) groups. Forty-eight hours after the intervention, fasting GLP-1R and PKBα gene expression in pancreatic tissue and plasma insulin and glucose levels were compared between the groups. Data were compared by independent t-test used to compare variables, version 22 between groups. A P< 0.05 was considered significant. Results: HIIT led to significant increase in PKBα gene expression (P: 0.001) and insulin (P: 0.031) and decreases in glucose concentration (P: 0.001) compared with the control group. No change was observed in the GLP-1R gene expression response to HIIT (P: 0.093). Conclusion: HIIT is associated with increased serum insulin levels in T2D obese rats. Despite no change in GLP-1R, this improvement is probably rooted in increased expression PKBα in pancreas in response to this type of exercise training","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"2 1‐5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18502/ijdo.v15i4.14557
Sachini M Thennakoon, N. Withanage
The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.
{"title":"Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review","authors":"Sachini M Thennakoon, N. Withanage","doi":"10.18502/ijdo.v15i4.14557","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14557","url":null,"abstract":"The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"359 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18502/ijdo.v15i4.14556
T. Addissouky, Majeed M. A. Ali, Ibrahim El Tantawy El Sayed, Yuliang Wang
Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting from inadequate insulin signaling. Current management relies on biomarkers such as hemoglobin A1c (HbA1c) to guide therapy, but emerging tools offer opportunities to transform care through more personalized approaches. Molecular biomarkers, including microRNAs, metabolites, and proteins, may enable better prediction of disease course and risk of complications in individuals. Genomic medicine leverages knowledge of genetic architecture to guide tailored prevention and treatment based on an individual’s genomic profile. Stem cell research differentiates functional insulin-secreting cells for transplantation into patients as an alternative to exogenous insulin. Gene silencing techniques such as RNA interference can restore defective insulin production and secretion pathways by inhibiting dysregulated gene expression. Artificial intelligence applications automate glucose monitoring, insulin delivery, diagnostic screening for complications, and digital health coaching. Despite barriers to translation, these technologies have disruptive potential for predictive, preventive, precise, and participatory care paradigms in diabetes management. Continued research on molecular biomarkers, pharmacogenomics, stem cell therapies, gene editing, and artificial intelligence (AI) aims to improve patient outcomes through more personalized approaches tailored to the specific biological vulnerabilities underlying each individual’s diabetes.
{"title":"Revolutionary Innovations in Diabetes Research: From Biomarkers to Genomic Medicine","authors":"T. Addissouky, Majeed M. A. Ali, Ibrahim El Tantawy El Sayed, Yuliang Wang","doi":"10.18502/ijdo.v15i4.14556","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14556","url":null,"abstract":"Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting from inadequate insulin signaling. Current management relies on biomarkers such as hemoglobin A1c (HbA1c) to guide therapy, but emerging tools offer opportunities to transform care through more personalized approaches. Molecular biomarkers, including microRNAs, metabolites, and proteins, may enable better prediction of disease course and risk of complications in individuals. Genomic medicine leverages knowledge of genetic architecture to guide tailored prevention and treatment based on an individual’s genomic profile. Stem cell research differentiates functional insulin-secreting cells for transplantation into patients as an alternative to exogenous insulin. Gene silencing techniques such as RNA interference can restore defective insulin production and secretion pathways by inhibiting dysregulated gene expression. Artificial intelligence applications automate glucose monitoring, insulin delivery, diagnostic screening for complications, and digital health coaching. Despite barriers to translation, these technologies have disruptive potential for predictive, preventive, precise, and participatory care paradigms in diabetes management. Continued research on molecular biomarkers, pharmacogenomics, stem cell therapies, gene editing, and artificial intelligence (AI) aims to improve patient outcomes through more personalized approaches tailored to the specific biological vulnerabilities underlying each individual’s diabetes.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"51 52","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18502/ijdo.v15i4.14559
Mohammad Mehdi Hakimian, N. Sedrpoushan, F. A. Shahreza
Objective: The purpose of this study was to investigate the effectiveness of acceptance and commitment based group therapy (ACT) with the Islamic approach to diabetes control, increasing self-care behaviors in patients with type II diabetes mellitus (T2DM) referent to the Yazd Diabetes Research Center. Materials and Methods: The study method was semi experimental with control group. For this purpose, 40 diabetic patients were randomly divided into two experimental and control groups. The study was in Yazd diabetes research center. The purposeful sampling method was done. So, all of the patients did the A1C hemoglobin test, and completed the self-care questionnaire for diabetic patients (SDSCA). Then, the experimental group received ACT with an Islamic approach during 16 weeks. The population of both groups performed the A1C Hemoglobin test and completed the self-care questionnaire again after performing the instructional plan. In this research, the covariance analysis test was done to analyze the results. Results: The findings of the research showed that ACT group therapy with an Islamic approach effects on HbA1c decreasing (P: 0.001) and self-care behaviors improvement (P: 0.001) in T2DM patients. Conclusion: This study showed that the treatment group based on commitment resulted in a significant reduction of HbA1 and a significant increase in self-care activities in patients with T2DM.
{"title":"Effectiveness of Acceptance and Commitment Based Group Therapy with the Islamic Approach on Diabetes Control and Increasing Self-Care Behaviors in Patients with Type II Diabetes in Yazd province.","authors":"Mohammad Mehdi Hakimian, N. Sedrpoushan, F. A. Shahreza","doi":"10.18502/ijdo.v15i4.14559","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14559","url":null,"abstract":"Objective: The purpose of this study was to investigate the effectiveness of acceptance and commitment based group therapy (ACT) with the Islamic approach to diabetes control, increasing self-care behaviors in patients with type II diabetes mellitus (T2DM) referent to the Yazd Diabetes Research Center. Materials and Methods: The study method was semi experimental with control group. For this purpose, 40 diabetic patients were randomly divided into two experimental and control groups. The study was in Yazd diabetes research center. The purposeful sampling method was done. So, all of the patients did the A1C hemoglobin test, and completed the self-care questionnaire for diabetic patients (SDSCA). Then, the experimental group received ACT with an Islamic approach during 16 weeks. The population of both groups performed the A1C Hemoglobin test and completed the self-care questionnaire again after performing the instructional plan. In this research, the covariance analysis test was done to analyze the results. Results: The findings of the research showed that ACT group therapy with an Islamic approach effects on HbA1c decreasing (P: 0.001) and self-care behaviors improvement (P: 0.001) in T2DM patients. Conclusion: This study showed that the treatment group based on commitment resulted in a significant reduction of HbA1 and a significant increase in self-care activities in patients with T2DM.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"53 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18502/ijdo.v15i4.14552
A. Mehrabbeik, Mohsen Mirzaei, Maryam Askari, Mohamad Ali Sahami, Mozhgan Minoosepehr, Nasim Namiranian
Objective: Diabetes mellitus is reported to be the third most prevalent comorbidity with COVID-19, after cardio‐cerebrovascular disease and hypertension. Furthermore, diabetes increases the likelihood of admission to the hospital and intensive care unit and death from COVID-19. The aim of the present study was to compare the clinical manifestations and outcomes of COVID-19 in diabetic versus non-diabetic inpatients. Materials and Methods: The medical records of 6525 patients with definitive diagnosis of COVID-19 were obtained from the reference COVID-19 diagnosis laboratory from January to July 2021 in Yazd, Iran. Patients were investigated for data on onset, clinical history, and fatality rate. COVID-19-related death was defined as positive RT-PCR in at least one of three nasal samples. Data were analysed using SPSS 24. Results: Among inpatients, 21.2% were diabetic. The mean ages of diabetic and non-diabetic patients were 64.45 (±13.87) and 52.98 (±20.36) years, respectively. Diabetics were more likely to be admitted to the intensive care unit (6.8% vs. 5%, P= 0.02) and the fatality rate was higher among them than non-diabetics (22.6% vs. 12%, P< 0.001). In diabetics, the mean age of non-survivors was lower than that of survivors (62.57 vs. 70.48, P= 0.0001) and the frequency of death was higher among men than women (53% vs. 47.5%, P= 0.045). Generally, diabetes has the strongest association with COVID-19 death (P= 0.0001). Conclusion: Diabetic patients experience more adverse outcomes because of COVID-19. These findings indicate the need for special attention in relation to prevention treatment against COVID-19 in patients with diabetes.
{"title":"Clinical Manifestations and Outcomes of COVID-19 in Diabetes Mellitus People, Yazd, Iran-2021","authors":"A. Mehrabbeik, Mohsen Mirzaei, Maryam Askari, Mohamad Ali Sahami, Mozhgan Minoosepehr, Nasim Namiranian","doi":"10.18502/ijdo.v15i4.14552","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14552","url":null,"abstract":"Objective: Diabetes mellitus is reported to be the third most prevalent comorbidity with COVID-19, after cardio‐cerebrovascular disease and hypertension. Furthermore, diabetes increases the likelihood of admission to the hospital and intensive care unit and death from COVID-19. The aim of the present study was to compare the clinical manifestations and outcomes of COVID-19 in diabetic versus non-diabetic inpatients. Materials and Methods: The medical records of 6525 patients with definitive diagnosis of COVID-19 were obtained from the reference COVID-19 diagnosis laboratory from January to July 2021 in Yazd, Iran. Patients were investigated for data on onset, clinical history, and fatality rate. COVID-19-related death was defined as positive RT-PCR in at least one of three nasal samples. Data were analysed using SPSS 24. Results: Among inpatients, 21.2% were diabetic. The mean ages of diabetic and non-diabetic patients were 64.45 (±13.87) and 52.98 (±20.36) years, respectively. Diabetics were more likely to be admitted to the intensive care unit (6.8% vs. 5%, P= 0.02) and the fatality rate was higher among them than non-diabetics (22.6% vs. 12%, P< 0.001). In diabetics, the mean age of non-survivors was lower than that of survivors (62.57 vs. 70.48, P= 0.0001) and the frequency of death was higher among men than women (53% vs. 47.5%, P= 0.045). Generally, diabetes has the strongest association with COVID-19 death (P= 0.0001). Conclusion: Diabetic patients experience more adverse outcomes because of COVID-19. These findings indicate the need for special attention in relation to prevention treatment against COVID-19 in patients with diabetes.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"28 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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