Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12967
R. Delbari, R. Fathi, A. Safarzade, K. Nasiri
Objective: Consuming too much fat or carbohydrates stimulates lipogenesis and excess fat is stored in non-fat tissues, including the liver, and manifests as obesity and fatty liver disease. This study aimed to investigate the effect of eight weeks of progressive resistance training (PRT) on the liver levels of some enzymes affecting lipid metabolism in rats fed a high-fat diet and sucrose solution. Materials and Methods: Twenty-four male wistar rats with 5 weeks of age were randomly divided into two groups: standard diet (SD) (n=8) and high-fat diet and sucrose solution (HFDS) (n=16). Twelve weeks later, HFDS group was divided into two groups: sedentary (HS) and PRT (HPRT). The PRT program was implemented 3 days a week for 8 weeks. Gene expression of AMPKα1, SCD-1, ATGL and FASN enzymes affecting lipid metabolism in liver tissue and its fat content were investigated. Results: HFDS significantly increased the body weight (P: 0.001) and significantly decreased the liver expression of ATGL and FASN (P: 0.001, P: 0.011). Eight weeks of PRT did not show a significant difference in the expression of AMPKα1, SCD-1, ATGL and FASN genes. Rats fed HFDS had considerably higher levels of triglyceride (TG) and total cholesterol (TC) in their liver tissue (P: 0.004, P: 0.001) and PRT did not affect them (P: 0.959, P: 0.809 respectively). Conclusion: It seems that eight weeks of PRT will not change liver lipid metabolism enzymes. Therefore, modifying the diet and changing it, will probably show different results after PRT.
{"title":"Investigating the Levels of Liver Lipogenic and Lipolytic Enzymes in Rat with High-Fat Diet and Sucrose Solution Underwent Progressive Resistance Training","authors":"R. Delbari, R. Fathi, A. Safarzade, K. Nasiri","doi":"10.18502/ijdo.v15i2.12967","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12967","url":null,"abstract":" Objective: Consuming too much fat or carbohydrates stimulates lipogenesis and excess fat is stored in non-fat tissues, including the liver, and manifests as obesity and fatty liver disease. This study aimed to investigate the effect of eight weeks of progressive resistance training (PRT) on the liver levels of some enzymes affecting lipid metabolism in rats fed a high-fat diet and sucrose solution. \u0000Materials and Methods: Twenty-four male wistar rats with 5 weeks of age were randomly divided into two groups: standard diet (SD) (n=8) and high-fat diet and sucrose solution (HFDS) (n=16). Twelve weeks later, HFDS group was divided into two groups: sedentary (HS) and PRT (HPRT). The PRT program was implemented 3 days a week for 8 weeks. Gene expression of AMPKα1, SCD-1, ATGL and FASN enzymes affecting lipid metabolism in liver tissue and its fat content were investigated. \u0000Results: HFDS significantly increased the body weight (P: 0.001) and significantly decreased the liver expression of ATGL and FASN (P: 0.001, P: 0.011). Eight weeks of PRT did not show a significant difference in the expression of AMPKα1, SCD-1, ATGL and FASN genes. Rats fed HFDS had considerably higher levels of triglyceride (TG) and total cholesterol (TC) in their liver tissue (P: 0.004, P: 0.001) and PRT did not affect them (P: 0.959, P: 0.809 respectively). \u0000Conclusion: It seems that eight weeks of PRT will not change liver lipid metabolism enzymes. Therefore, modifying the diet and changing it, will probably show different results after PRT.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45548691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12969
Reza Naseri Rad, M. Eizadi, Morteza Ghasemi
Objective: Overweight and obesity is associated with insulin resistance and is the most important risk factor of type 2 diabetes (T2DM). In present study, we assessed glycemic profile and insulin resistance response to a short term aerobic training in middle-aged men with abdominal obesity. Materials and Methods: The subjects included 28 abdominally obese (waist circumference≥102cm) middle-aged men (39 ± 5 year) that were divided into exercise (n=14) or control (n=14) groups by randomly. Exercise subject were completed a short-term aerobic training at 55-70 % of maximal heart rate (6 weeks, 3 times / weekly) and control subjects remained no training. Pre-training and post-training of anthropometrical markers, fasting glucose, hemoglobin (HbA1C), insulin and insulin resistance were measured of 2 groups and compared by independent – paired t test (SPSS, Version 22.0). Results: Aerobic exercise resulted in a significant decrease in glucose level (114 ± 13 versus 101 ± 11 mg/dL, P: 0.009) and HbA1C (6.14 ± 1.11 versus 4.91 ± 1.23, P: 0.021) in exercise group. But no significant changes were observed in insulin (8.31 ± 4.12 versus 8.29 ± 3.21, P: 0.119) and insulin resistance (2.34 ± 0.51 versus 2.07 ± 0.59, P: 0.073) in exercise groups. Conclusion: Based on our finding, aerobic training independent of insulin function is associated with improved glucose in middle-aged obese men and this improvement can be attributed to other changes caused by exercise that requires further study in this area.
{"title":"Improvement of Glucose Homeostasis in Response to Short-Term Aerobic Training in Middle-Aged Men with Abdominal Obesity","authors":"Reza Naseri Rad, M. Eizadi, Morteza Ghasemi","doi":"10.18502/ijdo.v15i2.12969","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12969","url":null,"abstract":"Objective: Overweight and obesity is associated with insulin resistance and is the most important risk factor of type 2 diabetes (T2DM). In present study, we assessed glycemic profile and insulin resistance response to a short term aerobic training in middle-aged men with abdominal obesity. \u0000Materials and Methods: The subjects included 28 abdominally obese (waist circumference≥102cm) middle-aged men (39 ± 5 year) that were divided into exercise (n=14) or control (n=14) groups by randomly. Exercise subject were completed a short-term aerobic training at 55-70 % of maximal heart rate (6 weeks, 3 times / weekly) and control subjects remained no training. Pre-training and post-training of anthropometrical markers, fasting glucose, hemoglobin (HbA1C), insulin and insulin resistance were measured of 2 groups and compared by independent – paired t test (SPSS, Version 22.0). \u0000Results: Aerobic exercise resulted in a significant decrease in glucose level (114 ± 13 versus 101 ± 11 mg/dL, P: 0.009) and HbA1C (6.14 ± 1.11 versus 4.91 ± 1.23, P: 0.021) in exercise group. But no significant changes were observed in insulin (8.31 ± 4.12 versus 8.29 ± 3.21, P: 0.119) and insulin resistance (2.34 ± 0.51 versus 2.07 ± 0.59, P: 0.073) in exercise groups. \u0000Conclusion: Based on our finding, aerobic training independent of insulin function is associated with improved glucose in middle-aged obese men and this improvement can be attributed to other changes caused by exercise that requires further study in this area.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41681745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12971
Amir Hossein Kheirkhah, Mohammad Javad Forouzani-Moghaddam, M. Afkhami-Ardakani
Objective: Diabetes is a chronic medical condition that can be caused by either inherited or acquired insufficiency insulin secretion, or the body's inability to effectively utilize the insulin it produces. There are three primary classifications of diabetes: type 1, type 2, and gestational diabetes. Type 2 diabetes mellitus (T2DM) is characterized by elevated levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c), indicating a disturbance in glucose metabolism. The term "probiotics" refers to living microorganisms that provide beneficial effects on the host's health. The effects of probiotics on T2DM in humans have shown conflicting results. Some studies have demonstrated that probiotic treatment substantially reduces HbA1c, FBG, or insulin resistance (IR) in patients with T2DM. However, other studies have found no significant difference between probiotic-treated patients and those receiving a placebo.. The use of probiotics was found to enhance glucose metabolism and HbA1c levels in individuals with T2DM. These findings are in line with previous reviews conducted on this topic.
{"title":"Relationship between Probiotics and Type 2 Diabetes Mellitus: A Review","authors":"Amir Hossein Kheirkhah, Mohammad Javad Forouzani-Moghaddam, M. Afkhami-Ardakani","doi":"10.18502/ijdo.v15i2.12971","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12971","url":null,"abstract":"Objective: Diabetes is a chronic medical condition that can be caused by either inherited or acquired insufficiency insulin secretion, or the body's inability to effectively utilize the insulin it produces. There are three primary classifications of diabetes: type 1, type 2, and gestational diabetes. Type 2 diabetes mellitus (T2DM) is characterized by elevated levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c), indicating a disturbance in glucose metabolism. The term \"probiotics\" refers to living microorganisms that provide beneficial effects on the host's health. The effects of probiotics on T2DM in humans have shown conflicting results. Some studies have demonstrated that probiotic treatment substantially reduces HbA1c, FBG, or insulin resistance (IR) in patients with T2DM. However, other studies have found no significant difference between probiotic-treated patients and those receiving a placebo.. The use of probiotics was found to enhance glucose metabolism and HbA1c levels in individuals with T2DM. These findings are in line with previous reviews conducted on this topic.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41482760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12964
F. Sefid, G. Azamirad, Samira Asadollahi, S. Kalantar, Saeede Khalilzade, Mohammad Yahya Vahidi Mehrjardi
Objective: Type 2 diabetes mellitus (T2DM) is a multifactorial genetic condition caused by the combination of genes and environmental factors. Several variations linked to T2DM have been discovered in recent genetic investigations, particularly genome-wide association studies (GWAS). This study aimed to investigate genes involved in T2DM, focusing on the NGS analysis and studying the genetic basis of T2DM to improve diagnosis, prevention, and treatment. Materials and Methods: We selected 5 families based on the diagnosis of diabetes at the age of 30 years or earlier in at least 3 consecutive generations for NGS analyses. Results: For each of the 5 participants tested thus far, a mean of 11 to 21 variants of clinical significance were detected. These variants were located in different genes, which indicate the association of these genes with susceptibility to diabetes. WFS1 and INS gene mutations were present in all five diabetic patients analyzed. Specifically, mutations in WFS1, KCNJ11, ABCC8, HNF1B, INS, GCKR, HNF1A and PCSK1N account for 25%, 13%, 8%, 7%, 7%, 6%, 6% and 6% of patients, respectively. Conclusion: WFS1 is the most often altered gene in our participants with putative alterations, according to our findings (25%). WFS1 mutations were discovered in all of the probands.
{"title":"Common Polymorphisms Identified In Patients with Type 2 Diabetes Mellitus Revealed From Next-Generation Sequencing Analysis","authors":"F. Sefid, G. Azamirad, Samira Asadollahi, S. Kalantar, Saeede Khalilzade, Mohammad Yahya Vahidi Mehrjardi","doi":"10.18502/ijdo.v15i2.12964","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12964","url":null,"abstract":"Objective: Type 2 diabetes mellitus (T2DM) is a multifactorial genetic condition caused by the combination of genes and environmental factors. Several variations linked to T2DM have been discovered in recent genetic investigations, particularly genome-wide association studies (GWAS). This study aimed to investigate genes involved in T2DM, focusing on the NGS analysis and studying the genetic basis of T2DM to improve diagnosis, prevention, and treatment. Materials and Methods: We selected 5 families based on the diagnosis of diabetes at the age of 30 years or earlier in at least 3 consecutive generations for NGS analyses. Results: For each of the 5 participants tested thus far, a mean of 11 to 21 variants of clinical significance were detected. These variants were located in different genes, which indicate the association of these genes with susceptibility to diabetes. WFS1 and INS gene mutations were present in all five diabetic patients analyzed. Specifically, mutations in WFS1, KCNJ11, ABCC8, HNF1B, INS, GCKR, HNF1A and PCSK1N account for 25%, 13%, 8%, 7%, 7%, 6%, 6% and 6% of patients, respectively. Conclusion: WFS1 is the most often altered gene in our participants with putative alterations, according to our findings (25%). WFS1 mutations were discovered in all of the probands.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46290551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12965
A. Ghadiri-anari, N. Namiranian, Hassan ali Mahmoudi Kohani, Roghaye Razavi, Saeedeh Jam Ashkezari, Z. Mozafari, M. Ordooei
Objective: Diabetes is a non-communicable disease. The patient satisfaction with treatment is a key point of patient’s compliance. Definitive treatment for patients with type 1 diabetes is lifelong insulin injections, but type 1 diabetic patients are commonly in poor glycemic state due to poor compliance. Therefore, it is necessary to check insulin treatment satisfaction in this population. Therefore, the main purpose of this study was to evaluate the satisfaction of insulin treatment in patients with type 1 diabetes in Yazd. Materials and Methods: In this cross-sectional study, 114 patients with type 1 diabetes participated. Persian version of Insulin Treatment Satisfaction Questionnaire (ITSQ) used. All analyzes were performed by SPSS 22. Results: The overall satisfaction mean score in this study was 49.72(± 8.88). Insulin treatment satisfaction score had a significant positive correlation with BMI (P: 0.00) and age (P: 0.04). Hypoglycemic control subscale showed a positive correlation with BMI (P: 0.01) and age (P: 0.01). Also, inconvenience of insulin therapy regimen sub-scale showed a significant positive correlation with age (P: 0.04). Overall satisfaction and sub-groups had no significant correlation with other variables. Conclusion: The overall satisfaction in type 1 diabetics was unacceptable. Understanding the pathogenesis of this problem could guide health care providers for better and effective management of type 1 diabetes. Also, a more comprehensive approach with consider all potentially relevant variables is necessary.
{"title":"The Satisfaction level with Insulin Treatment in Type 1 Diabetics - Yazd Diabetes Research Center 2019","authors":"A. Ghadiri-anari, N. Namiranian, Hassan ali Mahmoudi Kohani, Roghaye Razavi, Saeedeh Jam Ashkezari, Z. Mozafari, M. Ordooei","doi":"10.18502/ijdo.v15i2.12965","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12965","url":null,"abstract":"Objective: Diabetes is a non-communicable disease. The patient satisfaction with treatment is a key point of patient’s compliance. Definitive treatment for patients with type 1 diabetes is lifelong insulin injections, but type 1 diabetic patients are commonly in poor glycemic state due to poor compliance. Therefore, it is necessary to check insulin treatment satisfaction in this population. Therefore, the main purpose of this study was to evaluate the satisfaction of insulin treatment in patients with type 1 diabetes in Yazd. \u0000Materials and Methods: In this cross-sectional study, 114 patients with type 1 diabetes participated. Persian version of Insulin Treatment Satisfaction Questionnaire (ITSQ) used. All analyzes were performed by SPSS 22. \u0000Results: The overall satisfaction mean score in this study was 49.72(± 8.88). Insulin treatment satisfaction score had a significant positive correlation with BMI (P: 0.00) and age (P: 0.04). Hypoglycemic control subscale showed a positive correlation with BMI (P: 0.01) and age (P: 0.01). Also, inconvenience of insulin therapy regimen sub-scale showed a significant positive correlation with age (P: 0.04). Overall satisfaction and sub-groups had no significant correlation with other variables. \u0000Conclusion: The overall satisfaction in type 1 diabetics was unacceptable. Understanding the pathogenesis of this problem could guide health care providers for better and effective management of type 1 diabetes. Also, a more comprehensive approach with consider all potentially relevant variables is necessary.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46184920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12966
Tayyaba Khalid, M. Afzal, Aneela Amjad
Objective: To evaluate restless leg syndrome (RLS) in type 2 Diabetes Mellitus (T2DM) in Lahore. Materials and Methods: A cross-sectional study design was recruited for this study. Non-probability purposive sampling technique was used to select the patients in the study. The data was collected from the Pakistan Society for the Rehabilitation of Disabled (PSRD) Hospital and Hameed Latif Hospital Lahore. Patients diagnosed with T2DM with a maximum of 10 years, ages between 35 to 65 years, and patients who suffer from minor complications of diabetes mellitus were in cluded in the study. The RLS rating scale was used to assess the severity of restlessness in participants. Results: Out of 144 subjects, the frequency of the RLS was 71.5% and the majority was more in females as compared to male subjects. The female subjects have moderate severity of RLS while male subjects have mild severity of RLS. Conclusion: The frequency of RLS was high in patients with T2DM and females were more prone to RLS as compared to male subjects.
{"title":"Evaluation of Restless Leg Syndrome in Patients with Type 2 Diabetes Mellitus","authors":"Tayyaba Khalid, M. Afzal, Aneela Amjad","doi":"10.18502/ijdo.v15i2.12966","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12966","url":null,"abstract":"Objective: To evaluate restless leg syndrome (RLS) in type 2 Diabetes Mellitus (T2DM) in Lahore. \u0000Materials and Methods: A cross-sectional study design was recruited for this study. Non-probability purposive sampling technique was used to select the patients in the study. The data was collected from the Pakistan Society for the Rehabilitation of Disabled (PSRD) Hospital and Hameed Latif Hospital Lahore. Patients diagnosed with T2DM with a maximum of 10 years, ages between 35 to 65 years, and patients who suffer from minor complications of diabetes mellitus were in cluded in the study. The RLS rating scale was used to assess the severity of restlessness in participants. \u0000Results: Out of 144 subjects, the frequency of the RLS was 71.5% and the majority was more in females as compared to male subjects. The female subjects have moderate severity of RLS while male subjects have mild severity of RLS. \u0000Conclusion: The frequency of RLS was high in patients with T2DM and females were more prone to RLS as compared to male subjects. \u0000 ","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41444756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12963
Z. Entezari, Nastaran Injinari, M. Vakili, N. Namiranian
Objective: Type 2 diabetes mellitus (T2DM) is one of the most common metabolic diseases among women. Sexual dysfunction (SD) is a complication in patients with T2DM that has received less attention among women than men. This study aimed to assess the factors related to female SD in T2DM patients. Materials and Methods: 120 women with T2DM who referred to the Yazd Diabetes Center in 2019-2020 were selected. Female sexual function index (FSFI) as a valid questionnaire was used. Neuropathy, nephropathy, retinopathy, hyperlipidemia, hypertension, diabetes medication, Hb1Ac, age, and duration of diabetes as factors related to SD were assessed. The T-test and chi-square tests were used to analyze the data by SPSS 22 software. Results: The mean age of participants was 48.40 (±7.35). The SD was impaired in 85.8% of subjects and none of the participants showed a level of good function in any of the sexual domains. There was a significant relationship between SD and neuropathy (P= 0.005), hyperlipidemia (P= 0.007), hypertension (P= 0.015), diabetes medication (P= 0.005), age (P= 0.0001), and duration of diabetes (P= 0.0001). There was no significant relationship between SD and retinopathy (P= 0.565), nephropathy (P= 0.288), and Hb1Ac (P= 0.92). Conclusion: The frequency of SD in females with T2DM remarkably was high and the factors including age, duration of diabetes, diabetes medication, hypertension, hyperlipidemia, and neuropathy were identified as factors related to SD.
{"title":"Identification of Factors Related to Sexual Dysfunction in Type 2 Diabetic Women","authors":"Z. Entezari, Nastaran Injinari, M. Vakili, N. Namiranian","doi":"10.18502/ijdo.v15i2.12963","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12963","url":null,"abstract":"Objective: Type 2 diabetes mellitus (T2DM) is one of the most common metabolic diseases among women. Sexual dysfunction (SD) is a complication in patients with T2DM that has received less attention among women than men. This study aimed to assess the factors related to female SD in T2DM patients. \u0000Materials and Methods: 120 women with T2DM who referred to the Yazd Diabetes Center in 2019-2020 were selected. Female sexual function index (FSFI) as a valid questionnaire was used. Neuropathy, nephropathy, retinopathy, hyperlipidemia, hypertension, diabetes medication, Hb1Ac, age, and duration of diabetes as factors related to SD were assessed. The T-test and chi-square tests were used to analyze the data by SPSS 22 software. \u0000Results: The mean age of participants was 48.40 (±7.35). The SD was impaired in 85.8% of subjects and none of the participants showed a level of good function in any of the sexual domains. There was a significant relationship between SD and neuropathy (P= 0.005), hyperlipidemia (P= 0.007), hypertension (P= 0.015), diabetes medication (P= 0.005), age (P= 0.0001), and duration of diabetes (P= 0.0001). There was no significant relationship between SD and retinopathy (P= 0.565), nephropathy (P= 0.288), and Hb1Ac (P= 0.92). \u0000Conclusion: The frequency of SD in females with T2DM remarkably was high and the factors including age, duration of diabetes, diabetes medication, hypertension, hyperlipidemia, and neuropathy were identified as factors related to SD.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46186530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-20DOI: 10.18502/ijdo.v15i2.12968
Ghazaleh Hellinia, R. Homaei
Objective: Health literacy improves self-regulation and management of diabetes through proper diets in diabetic men. As a result, they will gain more knowledge about the effects of this disease on marital life and sexual relationships. The present study aimed to investigate the relationship between women’s marital intimacy with sexual satisfaction and health literacy among husbands with diabetes. Materials and Methods: The method of the present research was descriptive and correlational. The statistical population of the study included all male patients with diabetes and their wives in Ahvaz in 2021. Convenience sampling was done to select 140 diabetic men with their wives as the research sample. The research instruments included the Intimacy Questionnaire in Marital Relationships, the Index of Sexual Satisfaction, and Health Literacy for Iranian Adults. Pearson's correlation coefficient and simultaneous regression analysis were used for data analysis. Results: According to the results, sexual satisfaction and health literacy in diabetic men had significant positive relationships with the women’s marital intimacy (P< 0.001). Furthermore, regression results indicated that sexual satisfaction and health literacy had significant multiple correlations with marital intimacy (P< 0.001). Conclusion: The results highlighted the growing importance of paying attention to the roles of women’s sexual satisfaction and their diabetic husbands' health literacy in improving marital intimacy and strengthening both family and marital relationships
{"title":"Prediction of Women’s Marital Intimacy Based on Sexual Satisfaction and Health Literacy among Husbands with Diabetes in Ahvaz, 2021","authors":"Ghazaleh Hellinia, R. Homaei","doi":"10.18502/ijdo.v15i2.12968","DOIUrl":"https://doi.org/10.18502/ijdo.v15i2.12968","url":null,"abstract":"Objective: Health literacy improves self-regulation and management of diabetes through proper diets in diabetic men. As a result, they will gain more knowledge about the effects of this disease on marital life and sexual relationships. The present study aimed to investigate the relationship between women’s marital intimacy with sexual satisfaction and health literacy among husbands with diabetes. \u0000Materials and Methods: The method of the present research was descriptive and correlational. The statistical population of the study included all male patients with diabetes and their wives in Ahvaz in 2021. Convenience sampling was done to select 140 diabetic men with their wives as the research sample. The research instruments included the Intimacy Questionnaire in Marital Relationships, the Index of Sexual Satisfaction, and Health Literacy for Iranian Adults. Pearson's correlation coefficient and simultaneous regression analysis were used for data analysis. \u0000Results: According to the results, sexual satisfaction and health literacy in diabetic men had significant positive relationships with the women’s marital intimacy (P< 0.001). Furthermore, regression results indicated that sexual satisfaction and health literacy had significant multiple correlations with marital intimacy (P< 0.001). \u0000Conclusion: The results highlighted the growing importance of paying attention to the roles of women’s sexual satisfaction and their diabetic husbands' health literacy in improving marital intimacy and strengthening both family and marital relationships","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42695568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-13DOI: 10.18502/ijdo.v15i1.12206
Shiva Kordestani, Seyyed Behzad Razavi, M. Najaf Najafi, P. Layegh, Mohammad Mobin Miri Moghaddam, Amirali Aali, Masoud Mohebbi
Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention. Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant. Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably. Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.
{"title":"Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial","authors":"Shiva Kordestani, Seyyed Behzad Razavi, M. Najaf Najafi, P. Layegh, Mohammad Mobin Miri Moghaddam, Amirali Aali, Masoud Mohebbi","doi":"10.18502/ijdo.v15i1.12206","DOIUrl":"https://doi.org/10.18502/ijdo.v15i1.12206","url":null,"abstract":"Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention. \u0000 Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant. \u0000Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably. \u0000Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46275172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-13DOI: 10.18502/ijdo.v15i1.12207
Samaneh Motaghi, I. Rahimian Boogar, S. Moradi, Nemat Setoodeh Asl
Objective: This study aimed to investigate the effectiveness of cognitive behavioral stress management (CBSM) on health-related quality of life (HRQOL), self-efficacy of diabetes management, and adherence to treatment of patients with type 2 diabetes. Materials and Methods: The present study was a semi-experimental study with a control group. The research samples included 30 patients with type 2 diabetes. Data collection tools in this study included the Boyer & Earp quality of life (QOL) scale for patients with diabetes (D-39), the diabetes management self-efficacy scale (DMSES), and treatment adherence questionnaire in patients with chronic diseases. The CBSM therapy was performed in 8 sessions for the experimental group. To analyze the data, a univariate analysis of covariance was used with SPSS-23 software. Results: The results showed that the CBSM had a significant effect on the overall health-based QOL (F=8.620; P=0.007), diabetes management self-efficacy (F=12.021; P=0.002), and treatment adherence (F=83.253; P=0.0001). In addition, the CBSM has a significant effect on diabetes control (F=8.932; P=0.007), anxiety and worry (F=5.023; P=0.035), and sexual functioning (F=7.611; P=0.011), diet (F=10.041; P=0.004), therapeutic regimen (F=24.250; P=0.0001), making effort for treatment (F=22.987; P=0.0001), intention to take the treatment (F=108.001; P=0.0001), adaptability (F=28.704; P=0.0001), and integrating illness into life (F=38.263; P=0.0001). Conclusion: The CBSM intervention can be used to improve health-based QOL, diabetes management self-efficacy, and treatment adherence in type 2 diabetes patients.
{"title":"The Effectiveness of Cognitive Behavioral Stress Management on Health-Related Quality of Life, Diabetes Management Self-Efficacy, and Treatment Adherence in Type 2 Diabetes","authors":"Samaneh Motaghi, I. Rahimian Boogar, S. Moradi, Nemat Setoodeh Asl","doi":"10.18502/ijdo.v15i1.12207","DOIUrl":"https://doi.org/10.18502/ijdo.v15i1.12207","url":null,"abstract":"Objective: This study aimed to investigate the effectiveness of cognitive behavioral stress management (CBSM) on health-related quality of life (HRQOL), self-efficacy of diabetes management, and adherence to treatment of patients with type 2 diabetes. \u0000Materials and Methods: The present study was a semi-experimental study with a control group. The research samples included 30 patients with type 2 diabetes. Data collection tools in this study included the Boyer & Earp quality of life (QOL) scale for patients with diabetes (D-39), the diabetes management self-efficacy scale (DMSES), and treatment adherence questionnaire in patients with chronic diseases. The CBSM therapy was performed in 8 sessions for the experimental group. To analyze the data, a univariate analysis of covariance was used with SPSS-23 software. \u0000Results: The results showed that the CBSM had a significant effect on the overall health-based QOL (F=8.620; P=0.007), diabetes management self-efficacy (F=12.021; P=0.002), and treatment adherence (F=83.253; P=0.0001). In addition, the CBSM has a significant effect on diabetes control (F=8.932; P=0.007), anxiety and worry (F=5.023; P=0.035), and sexual functioning (F=7.611; P=0.011), diet (F=10.041; P=0.004), therapeutic regimen (F=24.250; P=0.0001), making effort for treatment (F=22.987; P=0.0001), intention to take the treatment (F=108.001; P=0.0001), adaptability (F=28.704; P=0.0001), and integrating illness into life (F=38.263; P=0.0001). \u0000Conclusion: The CBSM intervention can be used to improve health-based QOL, diabetes management self-efficacy, and treatment adherence in type 2 diabetes patients.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48638662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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