Pub Date : 2022-09-21DOI: 10.18502/ijdo.v14i3.10738
V. Jai̇n, Swati Ghanghurde, S. Carvalho, S. Nirgudkar, M. Rojekar
Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters. Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the study. Their blood samples were analysed for fasting blood glucose (FBG), glycosylated haemoglobin (HbA1C), total tri-iodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid-stimulating hormone (TSH), total cholesterol (CHOL), High-Density-Lipoprotein cholesterol (HDLC) and Low-Density-Lipoprotein cholesterol (LDLC). Data was analysed using appropriate statistical tests. Results: Among the cases, 70.37% were euthyroid, while 24.7% had subclinical hypothyroidism, 2.47% had clinical hypothyroidism, 1.23% had subclinical and 1.23% had clinical hyperthyroidism. FBG, HbA1c and TSH (P< 0.05) were significantly higher in diabetics compared to controls. On the other hand, T3, FT3, FT4, and HDLC (P< 0.05) were significantly lower in diabetics compared to controls. A significant negative correlation (P< 0.05) was found when T3 and FT3 were compared against age, FBG and HbA1c. A significant positive correlation (P< 0.05) was found when T3 and FT3 were compared against HDLC, LDLC & CHOL. Conclusion: Our statistics show that high-normal levels of T3 and FT3 are correlated with lower levels of FBG and HbA1c, hence improved glycaemic control. We recommend that thyroid profile of diabetic patients with poor control should be monitored regularly. Early detection of thyroid dysfunction and initiation of therapy for it, can improve the treatment outcome of hypoglycaemic drugs.
{"title":"Effect of Thyroid Hormone Levels on Glycemic Control: The Indian Context","authors":"V. Jai̇n, Swati Ghanghurde, S. Carvalho, S. Nirgudkar, M. Rojekar","doi":"10.18502/ijdo.v14i3.10738","DOIUrl":"https://doi.org/10.18502/ijdo.v14i3.10738","url":null,"abstract":"Objective: Diabetes mellitus (DM) is known as the silent pandemic. It is hypothesized that other endocrine systems are affected by the metabolic changes occurring due to DM. We aimed to investigate the correlation of thyroid hormones with glycaemic and lipid parameters. \u0000Materials and Methods: 81 diabetic patients and 81 non-diabetic age and sex-matched healthy volunteers participated in the study. Their blood samples were analysed for fasting blood glucose (FBG), glycosylated haemoglobin (HbA1C), total tri-iodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid-stimulating hormone (TSH), total cholesterol (CHOL), High-Density-Lipoprotein cholesterol (HDLC) and Low-Density-Lipoprotein cholesterol (LDLC). Data was analysed using appropriate statistical tests. \u0000Results: Among the cases, 70.37% were euthyroid, while 24.7% had subclinical hypothyroidism, 2.47% had clinical hypothyroidism, 1.23% had subclinical and 1.23% had clinical hyperthyroidism. FBG, HbA1c and TSH (P< 0.05) were significantly higher in diabetics compared to controls. On the other hand, T3, FT3, FT4, and HDLC (P< 0.05) were significantly lower in diabetics compared to controls. A significant negative correlation (P< 0.05) was found when T3 and FT3 were compared against age, FBG and HbA1c. A significant positive correlation (P< 0.05) was found when T3 and FT3 were compared against HDLC, LDLC & CHOL. \u0000Conclusion: Our statistics show that high-normal levels of T3 and FT3 are correlated with lower levels of FBG and HbA1c, hence improved glycaemic control. We recommend that thyroid profile of diabetic patients with poor control should be monitored regularly. Early detection of thyroid dysfunction and initiation of therapy for it, can improve the treatment outcome of hypoglycaemic drugs.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42898299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.18502/ijdo.v14i3.10743
Behroz Khodayari, M. Dehghan, R. Nouri, A. Gaeini, M. Kordi
Objective: Evaluation of the effect of 8 weeks of High-Intensity Interval Training (HIIT) on the serum level of cardiac troponin T (cTnT) in sedentary obese young men. Materials and Methods: Thirty sedentary men were randomly divided into 3 groups: the 30s HIIT training group (n=10), the 60s training group (n=10), and the control group (no exercise) (n=10). Interval training with 90 %VO2peak was done in 3 sessions for 8 weeks. cTnT was measured 5 times; pre-exercise, 4hrs, and 24hrs after the first session (4hF, 24hF), and 4hrs and 24hrs after the last training session (4hL, 24hL). ANOVA with repeated measures and Bonferroni post-hoc tests were used by SPSS 23 with a significance level of (P< 0.05). Results: The significant increase in serum levels of cTnT in the post-tests of the 60s HIIT compared to the first 24hrs and the last 24hrs (P= 0.0001). But in the 30s group it was not significant compared to the other measurements (P≥ 0/05). In the 2 training groups, serum levels of cTnT in the last 4hr post-tests of the last week were not significantly different from the 4hrs post-tests of the first week (P≥ 0.05). Conclusion: It seems that none of these activities cause heart damage sustained, and changes in cTnT levels in two 4hrs compared to the first and last 24hrs of the 60s group may be due to reversible leakage of cardiac cell membranes, and may continuous exercise will reduce this reduction.
{"title":"The Impact of HIIT on the cTnT Response in Sedentary Obese Young Men","authors":"Behroz Khodayari, M. Dehghan, R. Nouri, A. Gaeini, M. Kordi","doi":"10.18502/ijdo.v14i3.10743","DOIUrl":"https://doi.org/10.18502/ijdo.v14i3.10743","url":null,"abstract":"Objective: Evaluation of the effect of 8 weeks of High-Intensity Interval Training (HIIT) on the serum level of cardiac troponin T (cTnT) in sedentary obese young men. \u0000Materials and Methods: Thirty sedentary men were randomly divided into 3 groups: the 30s HIIT training group (n=10), the 60s training group (n=10), and the control group (no exercise) (n=10). Interval training with 90 %VO2peak was done in 3 sessions for 8 weeks. cTnT was measured 5 times; pre-exercise, 4hrs, and 24hrs after the first session (4hF, 24hF), and 4hrs and 24hrs after the last training session (4hL, 24hL). ANOVA with repeated measures and Bonferroni post-hoc tests were used by SPSS 23 with a significance level of (P< 0.05). \u0000Results: The significant increase in serum levels of cTnT in the post-tests of the 60s HIIT compared to the first 24hrs and the last 24hrs (P= 0.0001). But in the 30s group it was not significant compared to the other measurements (P≥ 0/05). In the 2 training groups, serum levels of cTnT in the last 4hr post-tests of the last week were not significantly different from the 4hrs post-tests of the first week (P≥ 0.05). \u0000Conclusion: It seems that none of these activities cause heart damage sustained, and changes in cTnT levels in two 4hrs compared to the first and last 24hrs of the 60s group may be due to reversible leakage of cardiac cell membranes, and may continuous exercise will reduce this reduction.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48972723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.18502/ijdo.v14i2.9455
Shahram Soheily, M. Eizadi
Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D. Materials and Methods: 21 male wistar rats (220±20 g) were obese by 6 weeks high fat diet (HFD) and randomly assigned to either non-diabetes (n=7) or two T2D groups (control and exercise groups, n=7 in each case). Fasting glucose, insulin, insulin resistance and FOXO1 expression were compared between non-diabetes and diabetes groups. All variables were also assigned after resistance training in the form of climbing a ladder (6 weeks/5 times weekly) in exercise compare with control groups. Data were compared by ANOVA, independent and paired t-test methods (P<0.05). Results: Induction of diabetes resulted in significant increase in insulin resistance, glucose, and FOXO expression in SA tissue and a decrease in insulin compared to obese health rats (P< 0.0001). A significant decrease in fasting insulin (P< 0.0001), insulin resistance (P< 0.0001) and FOXO1 expression in SA tissue (P< 0.0001) and increase in insulin (P: 0.002) were observed by resistance training compared to control diabetes rats. Conclusion: Based on our results, improving insulin resistance and glucose in response to resistance training in obese diabetic rats may be rooted in decreased insulin expression following these exercises.
{"title":"Over Expression of FOXO1 in Subcutaneous Fatty Tissue and its Response to Resistance Training in High Fat Diet and Type 2 Diabetic Rat","authors":"Shahram Soheily, M. Eizadi","doi":"10.18502/ijdo.v14i2.9455","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9455","url":null,"abstract":"Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D. \u0000Materials and Methods: 21 male wistar rats (220±20 g) were obese by 6 weeks high fat diet (HFD) and randomly assigned to either non-diabetes (n=7) or two T2D groups (control and exercise groups, n=7 in each case). Fasting glucose, insulin, insulin resistance and FOXO1 expression were compared between non-diabetes and diabetes groups. All variables were also assigned after resistance training in the form of climbing a ladder (6 weeks/5 times weekly) in exercise compare with control groups. Data were compared by ANOVA, independent and paired t-test methods (P<0.05). \u0000Results: Induction of diabetes resulted in significant increase in insulin resistance, glucose, and FOXO expression in SA tissue and a decrease in insulin compared to obese health rats (P< 0.0001). A significant decrease in fasting insulin (P< 0.0001), insulin resistance (P< 0.0001) and FOXO1 expression in SA tissue (P< 0.0001) and increase in insulin (P: 0.002) were observed by resistance training compared to control diabetes rats. \u0000Conclusion: Based on our results, improving insulin resistance and glucose in response to resistance training in obese diabetic rats may be rooted in decreased insulin expression following these exercises.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45455631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.18502/ijdo.v14i2.9456
B. Fallah, A. Mehrabbeik, N. Salmani
Objective: The use of medicinal plants in diabetic patients is rising, it is essential to increase knowledge about the effects of medicinal plants and subsequently perform evidence-based action, so, review studies are a helpful way for the present purpose. Current study was conducted to investigate the clinical trials of medicinal plants used in the treatment of diabetes in Iran. Materials and Methods: Articles published online between 2010 - 2020 were googled in Magiran, SID, Scopus, and, Iran Medex with Persian keywords such as “type 2 diabetes”, “medicinal herbs”, “healing herbs” “herbs”, “medicinal plants” and “clinical trial”. The inclusion criteria for articles were conducting in the form of a clinical trial, conducting in Iran, publishing in Persian language and having at least a score of 3 based on the Jadad scale. Results: 20 clinical trial studies were extracted. Five studies were conducted on cinnamon and two studies on cumin and the rest of the plants were examined just in one study. Although some trials showed positive effects of the medicinal plants on reducing fasting blood sugar (FBS) and glycosylated hemoglobin (HbA1c), some others demonstrated that medicinal plants had no effect on important variables in diabetes control. Conclusion: Conclusions about the benefits of plants should be made with caution, safety and efficacy of plants in the treatment of diabetes should be investigated further. It is essential that patients take any herbal supplements under physician’s supervision and after receiving the necessary advice.
{"title":"A Review of Clinical Trial Studies on Medicinal Plants in the Treatment of Diabetes","authors":"B. Fallah, A. Mehrabbeik, N. Salmani","doi":"10.18502/ijdo.v14i2.9456","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9456","url":null,"abstract":"Objective: The use of medicinal plants in diabetic patients is rising, it is essential to increase knowledge about the effects of medicinal plants and subsequently perform evidence-based action, so, review studies are a helpful way for the present purpose. Current study was conducted to investigate the clinical trials of medicinal plants used in the treatment of diabetes in Iran. \u0000Materials and Methods: Articles published online between 2010 - 2020 were googled in Magiran, SID, Scopus, and, Iran Medex with Persian keywords such as “type 2 diabetes”, “medicinal herbs”, “healing herbs” “herbs”, “medicinal plants” and “clinical trial”. The inclusion criteria for articles were conducting in the form of a clinical trial, conducting in Iran, publishing in Persian language and having at least a score of 3 based on the Jadad scale. \u0000Results: 20 clinical trial studies were extracted. Five studies were conducted on cinnamon and two studies on cumin and the rest of the plants were examined just in one study. Although some trials showed positive effects of the medicinal plants on reducing fasting blood sugar (FBS) and glycosylated hemoglobin (HbA1c), some others demonstrated that medicinal plants had no effect on important variables in diabetes control. \u0000Conclusion: Conclusions about the benefits of plants should be made with caution, safety and efficacy of plants in the treatment of diabetes should be investigated further. It is essential that patients take any herbal supplements under physician’s supervision and after receiving the necessary advice.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49523459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.18502/ijdo.v14i2.9450
Fatemeh Bidmeshki, Narjes Hazar, M. Mirzaei, M. Rahmanian
Objective: Obesity is a major public health concern and there are different ways to detect it in population. The aim of the present study is to evaluate the neck circumference (NC) in a simple and practical way. Materials and Methods: This cross-sectional survey utilized data from the Yazd Health Study (YaHS) which is a population-based cohort study. In brief, 9962 individuals aged 20-70 years with measurement of body weight, height, waist circumference (WC) and NC were available for analysis. To determine the relationship between NC and other anthropometric measurement, we utilized of Pearson's correlation coefficient. Receiver operator characteristic (ROC) curve analysis was used to find out an optimal cut off value for detecting general and central obesity as well as to determine the sensitivity and specificity of NC in predicting general and central obesity. The whole analysis was performed using SPSS version 22. Results: NC correlated positively with body mass index (BMI) (r= 0.608, P< 0.001 in men and r= 0.541, P< 0.001 in women) and WC (r= 0.662, P< 0.001 in men and r= 0.542, P< 0.001 in women). The best cut-off point for NC to determine people with general obesity was 40.25 cm for men and 35.75 cm for women. Conclusion: The NC has an acceptable correlation with BMI and WC. In addition, NC is a simple free measurement which may be utilized in various health-care settings. These properties make the NC as the best anthropometrics to determine overweight and obesity and it can be used as an appropriate predictor for overweight and obesity in population-based screening programs.
{"title":"Finding an Appropriate Cut-off Point for Neck Circumference to Determine Overweight and Obesity in a Large Sample of Iranian Adults","authors":"Fatemeh Bidmeshki, Narjes Hazar, M. Mirzaei, M. Rahmanian","doi":"10.18502/ijdo.v14i2.9450","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9450","url":null,"abstract":"Objective: Obesity is a major public health concern and there are different ways to detect it in population. The aim of the present study is to evaluate the neck circumference (NC) in a simple and practical way. \u0000Materials and Methods: This cross-sectional survey utilized data from the Yazd Health Study (YaHS) which is a population-based cohort study. In brief, 9962 individuals aged 20-70 years with measurement of body weight, height, waist circumference (WC) and NC were available for analysis. To determine the relationship between NC and other anthropometric measurement, we utilized of Pearson's correlation coefficient. Receiver operator characteristic (ROC) curve analysis was used to find out an optimal cut off value for detecting general and central obesity as well as to determine the sensitivity and specificity of NC in predicting general and central obesity. The whole analysis was performed using SPSS version 22. \u0000Results: NC correlated positively with body mass index (BMI) (r= 0.608, P< 0.001 in men and r= 0.541, P< 0.001 in women) and WC (r= 0.662, P< 0.001 in men and r= 0.542, P< 0.001 in women). The best cut-off point for NC to determine people with general obesity was 40.25 cm for men and 35.75 cm for women. \u0000Conclusion: The NC has an acceptable correlation with BMI and WC. In addition, NC is a simple free measurement which may be utilized in various health-care settings. These properties make the NC as the best anthropometrics to determine overweight and obesity and it can be used as an appropriate predictor for overweight and obesity in population-based screening programs.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45735442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Determination of HbA1c level is a precious indicator for therapeutic follow-up of patients with type 1 or type 2 diabetes. Our study aimed to evaluate the analytical characteristics of Capillarys 3 Octa® HbA1c measurement by capillary electrophoresis. Materials and Methods: Our study involved 265 venous whole blood specimens repeatability, intermediate fidelity, accuracy, linearity, and correlation with the Arkray HA-8180 analyzer which uses HPLC as a dosing method. We studied interferences such as hematocrit, triglycerides, total bilirubin, labile fraction, and hemoglobin abnormalities. Results: The linearity correlation was between 4.4% and 20.3%. There was a strong correlation with HPLC (r > 0.99, P< 0.0001). No interference from hematocrit (20-93%) (P: 0.888), triglycerides (until 25 mmol/L) (P: 0.388), total bilirubin (< 587 µmol/L) (P: 0.993), and labile fraction was observed. No problem related to inter-sample contamination was observed. The sensitivity was zero for homozygous sickle cell disease and S/C composite hemoglobinosis. However, sensitivity was high for heterozygous forms (69% for A/S and 60% for A/C). The analyzer was able to separate and quantify HbA2 fraction, allowing ß-thalassemia accidental detection. Conclusion: Capillarys 3 Octa® based on capillary electrophoresis proved to be precise and a linear instrument for HbA1c measurement. Several clinical interferences and Hb variants had no effect on the results. The results of this evaluation suggest that this analyzer is suitable for routine use in clinical chemistry laboratories.
{"title":"Capillarys 3 Octa®: Analytical Performance Assessment for HbA1c Quantification","authors":"Ganouni Mohamed Rayen, Chaira Maha, Bouslama Jamila, Neffati Fadoua, Nejjar Mohamed Fadhel","doi":"10.18502/ijdo.v14i2.9453","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9453","url":null,"abstract":"Objective: Determination of HbA1c level is a precious indicator for therapeutic follow-up of patients with type 1 or type 2 diabetes. Our study aimed to evaluate the analytical characteristics of Capillarys 3 Octa® HbA1c measurement by capillary electrophoresis. \u0000Materials and Methods: Our study involved 265 venous whole blood specimens repeatability, intermediate fidelity, accuracy, linearity, and correlation with the Arkray HA-8180 analyzer which uses HPLC as a dosing method. We studied interferences such as hematocrit, triglycerides, total bilirubin, labile fraction, and hemoglobin abnormalities. \u0000Results: The linearity correlation was between 4.4% and 20.3%. There was a strong correlation with HPLC (r > 0.99, P< 0.0001). No interference from hematocrit (20-93%) (P: 0.888), triglycerides (until 25 mmol/L) (P: 0.388), total bilirubin (< 587 µmol/L) (P: 0.993), and labile fraction was observed. No problem related to inter-sample contamination was observed. The sensitivity was zero for homozygous sickle cell disease and S/C composite hemoglobinosis. However, sensitivity was high for heterozygous forms (69% for A/S and 60% for A/C). The analyzer was able to separate and quantify HbA2 fraction, allowing ß-thalassemia accidental detection. \u0000Conclusion: Capillarys 3 Octa® based on capillary electrophoresis proved to be precise and a linear instrument for HbA1c measurement. Several clinical interferences and Hb variants had no effect on the results. The results of this evaluation suggest that this analyzer is suitable for routine use in clinical chemistry laboratories.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46358236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.18502/ijdo.v14i2.9454
F. Nikseresht, M. Bahrami, M. Rahmati
Objective: Hepatic glucose release plays a potential role in hyperglycemia in type 2 diabetes (T2D) patients. The aim of this experimental study was to determine the effect of 6 weeks of high-intensity interval training (HIIT) on fasting levels of glucose and insulin as well as glucokinase (GCK) expression in liver tissue in obese T2D rats. Materials and Methods: T2D was induced by a high-fat diet (HFD) and streptozotocin (STZ) intraperitoneal injection in 14 male wistar rats, then were randomly divided into HIIT (n=7) and control (n=7) groups. The HIIT group practiced 6-week HIIT (5 days/ weekly). Finally, 48 hours after the last session, fasting levels of glucose, insulin, and GCK expression in liver hepatocytes of both groups were measured and compared by independent T-test (SPSS, Version 22.0). Results: HIIT resulted in a significant decrease of fasting glucose compared to the control group (P< 0.0001). Compared with the control group, serum insulin (P: 0.018) and GCK expression in hepatocytes (P: 0.030) were significantly increased. Conclusion: Based on these findings, the improvement in glucose in response to HIIT may be rooted in increased insulin and GCK expression in hepatocytes. However, understanding the mechanisms responsible for the effect of exercise training on the processes affecting hepatic glucose release requires further studies.
目的:肝脏葡萄糖释放在2型糖尿病(T2D)患者高血糖中发挥潜在作用。本实验研究的目的是确定6周高强度间歇训练(HIIT)对肥胖t2dm大鼠空腹葡萄糖和胰岛素水平以及肝组织葡萄糖激酶(GCK)表达的影响。材料与方法:采用高脂饲料(HFD)和腹腔注射链脲佐菌素(STZ)诱导14只雄性wistar大鼠发生T2D，随机分为HIIT组(n=7)和对照组(n=7)。HIIT组进行为期6周的HIIT训练(每周5天)。最后，在最后一次治疗后48小时，通过独立t检验(SPSS, Version 22.0)测量两组患者的空腹血糖水平、胰岛素水平和肝细胞GCK表达水平，并进行比较。结果:与对照组相比，HIIT组空腹血糖显著降低(P< 0.0001)。与对照组相比，血清胰岛素(P: 0.018)和肝细胞GCK表达量(P: 0.030)显著升高。结论:基于这些发现，HIIT对葡萄糖的改善可能源于肝细胞中胰岛素和GCK表达的增加。然而，了解运动训练对影响肝葡萄糖释放过程的影响的机制需要进一步的研究。
{"title":"The Effect of Interval Training on GCK Expression in Hepatocytes and Glucose Homeostasis in Type 2 Diabetes Rats","authors":"F. Nikseresht, M. Bahrami, M. Rahmati","doi":"10.18502/ijdo.v14i2.9454","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9454","url":null,"abstract":"Objective: Hepatic glucose release plays a potential role in hyperglycemia in type 2 diabetes (T2D) patients. The aim of this experimental study was to determine the effect of 6 weeks of high-intensity interval training (HIIT) on fasting levels of glucose and insulin as well as glucokinase (GCK) expression in liver tissue in obese T2D rats. \u0000Materials and Methods: T2D was induced by a high-fat diet (HFD) and streptozotocin (STZ) intraperitoneal injection in 14 male wistar rats, then were randomly divided into HIIT (n=7) and control (n=7) groups. The HIIT group practiced 6-week HIIT (5 days/ weekly). Finally, 48 hours after the last session, fasting levels of glucose, insulin, and GCK expression in liver hepatocytes of both groups were measured and compared by independent T-test (SPSS, Version 22.0). \u0000Results: HIIT resulted in a significant decrease of fasting glucose compared to the control group (P< 0.0001). Compared with the control group, serum insulin (P: 0.018) and GCK expression in hepatocytes (P: 0.030) were significantly increased. \u0000Conclusion: Based on these findings, the improvement in glucose in response to HIIT may be rooted in increased insulin and GCK expression in hepatocytes. However, understanding the mechanisms responsible for the effect of exercise training on the processes affecting hepatic glucose release requires further studies. \u0000 ","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48979339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.18502/ijdo.v14i2.9451
Mohsen Akbarpour Beni, Raziye Bakhteyari
Objective: This study aimed to compare the effect of eight weeks of traditional resistance training and total body resistance exercise (TRX) on the immune system of obese sedentary women. Materials and Methods: In this quasi-experimental study, 28 obese women with a mean body mass index (BMI) of 30.39± 4.65 (kg/m2) were randomly divided into three groups of TRX training (N= 9), traditional resistance training (N= 9) and control (N= 10). The experimental groups performed exercise training in three sessions per week for 8 weeks. Blood samples were taken from all subjects 48 hours before and after the last training session and were used for neutrophil, lymphocyte, monocyte, basophil, and eosinophil analysis. Data were statistically analyzed using dependent T-test and one-way analysis of variance (ANOVA) by SPSS software, the significance level was P< 0.05. Results: The results of the study did not show significant differences within and between groups in the variables of the immune system (neutrophils, lymphocytes, monocytes, eosinophils) (P< 0.05). Also, the results of ANOVA showed a significant difference in basophil count only between the three groups (P= 0.006). Conclusion: According to the results of the study, no significant difference in immune system indices was observed between the groups. Therefore, performing traditional resistance exercises and moderate-intensity TRX has no significant effect on the immune system of sedentary obese women.
{"title":"Comparison of the Effects of Total Body Resistance Exercise and Traditional Resistance Training on the Immune System Biomarker in Inactive Obese Women","authors":"Mohsen Akbarpour Beni, Raziye Bakhteyari","doi":"10.18502/ijdo.v14i2.9451","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9451","url":null,"abstract":"Objective: This study aimed to compare the effect of eight weeks of traditional resistance training and total body resistance exercise (TRX) on the immune system of obese sedentary women. \u0000Materials and Methods: In this quasi-experimental study, 28 obese women with a mean body mass index (BMI) of 30.39± 4.65 (kg/m2) were randomly divided into three groups of TRX training (N= 9), traditional resistance training (N= 9) and control (N= 10). The experimental groups performed exercise training in three sessions per week for 8 weeks. Blood samples were taken from all subjects 48 hours before and after the last training session and were used for neutrophil, lymphocyte, monocyte, basophil, and eosinophil analysis. Data were statistically analyzed using dependent T-test and one-way analysis of variance (ANOVA) by SPSS software, the significance level was P< 0.05. \u0000Results: The results of the study did not show significant differences within and between groups in the variables of the immune system (neutrophils, lymphocytes, monocytes, eosinophils) (P< 0.05). Also, the results of ANOVA showed a significant difference in basophil count only between the three groups (P= 0.006). \u0000Conclusion: According to the results of the study, no significant difference in immune system indices was observed between the groups. Therefore, performing traditional resistance exercises and moderate-intensity TRX has no significant effect on the immune system of sedentary obese women.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46529622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.18502/ijdo.v14i2.9452
Sara Jahandarpour, M. Sobhani
Objective: Yoga has also been implemented in healthcare institutions to manage disease-sequelae, including pain, anxiety, depression, fatigue, and insomnia. In this study, we aimed to evaluate the effect of Yoga-based mindfulness training on anxiety and depression in adolescents with type 1 diabetes (T1D) at clinics of the Shiraz University of Medical Science. Materials and Methods: This study was conducted via a quasi-experimental method pretest-posttest design on 10-17 years old subjects with T1D, Shiraz, Iran, in 2019-2020. Twenty patients were randomized to the education group (n=10) and the control group (n=10). Data collection tools included the depression, anxiety, and stress scale (DASS-21). The group training intervention was done for the experimental group (ten weeks, 45 minutes every week) without training for the control group. Three months after the training, two groups filled questionnaires. Data were analyzed by multivariate analysis of covariance (MANCOVA) using SPSS- 22 software. Results: The findings revealed a significant reduction in the mean anxiety level of patients in the intervention group before and after intervention (P< 0.05). Furthermore, following group training, there was a significant change in the mean of depression and stress among the patients in the intervention group (P< 0.05). Conclusion: Yoga-based mindfulness training was found to improve depression and anxiety in T1DM adolescents. As a consequence, including training sessions in the appropriate care plans would be advantageous.
{"title":"Yoga-based Mindfulness Training as an Intervention for the Reduction of Symptoms of Anxiety and Depression in Children and Adolescents with Type 1 Diabetes","authors":"Sara Jahandarpour, M. Sobhani","doi":"10.18502/ijdo.v14i2.9452","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9452","url":null,"abstract":"Objective: Yoga has also been implemented in healthcare institutions to manage disease-sequelae, including pain, anxiety, depression, fatigue, and insomnia. In this study, we aimed to evaluate the effect of Yoga-based mindfulness training on anxiety and depression in adolescents with type 1 diabetes (T1D) at clinics of the Shiraz University of Medical Science. \u0000Materials and Methods: This study was conducted via a quasi-experimental method pretest-posttest design on 10-17 years old subjects with T1D, Shiraz, Iran, in 2019-2020. Twenty patients were randomized to the education group (n=10) and the control group (n=10). Data collection tools included the depression, anxiety, and stress scale (DASS-21). The group training intervention was done for the experimental group (ten weeks, 45 minutes every week) without training for the control group. Three months after the training, two groups filled questionnaires. Data were analyzed by multivariate analysis of covariance (MANCOVA) using SPSS- 22 software. \u0000Results: The findings revealed a significant reduction in the mean anxiety level of patients in the intervention group before and after intervention (P< 0.05). Furthermore, following group training, there was a significant change in the mean of depression and stress among the patients in the intervention group (P< 0.05). \u0000Conclusion: Yoga-based mindfulness training was found to improve depression and anxiety in T1DM adolescents. As a consequence, including training sessions in the appropriate care plans would be advantageous.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46445554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.18502/ijdo.v14i2.9449
Mina Shafakhah, Sima Bijan
Objective: This study aimed to evaluate the effectiveness of emotion regulation training on depression and emotion regulation strategies of pediatric type I diabetes. Materials and Methods: The study used a quasi-experimental approach that included pre-and post-test assessments to compare the experimental and control groups. The University of Medical Sciences in Shiraz, provided services to a total of 30 patients. Patients were chosen using purposive sampling and were randomly allocated to either the experimental group (n=15) or the control group (n=15) Pediatric types I diabetes. The Beck Depression Inventory (BDI-II) and the Gross and John Emotion Regulation Questionnaire were used to collecting data. The experimental group got eight training sessions on depression and emotional regulation (once a week for two months), whereas the control group got no instruction. The data was analyzed using an analysis of covariance by SPSS.23. Results: The mean (±SD) of age in the experimental group and control groups were determined to be 14.60 (±0.88) and 14.46 (±073) years, respectively. According to the results, emotion regulation training had a significant effect in decreasing depression and increasing the adaptive emotional regulation strategies in students (P> 0.001). Conclusion: Emotion regulation training might be a useful strategy for improving emotion regulation difficulties in patients with type I diabetes, according to the findings of this investigation, although the efficacy of emotion regulation training was not approved in this investigation due to a lack of intervention factors.
{"title":"Investigation of the Effectiveness of Emotion Regulation Training on Emotion Regulation Strategies and Depression of Pediatric type I Diabetes","authors":"Mina Shafakhah, Sima Bijan","doi":"10.18502/ijdo.v14i2.9449","DOIUrl":"https://doi.org/10.18502/ijdo.v14i2.9449","url":null,"abstract":"Objective: This study aimed to evaluate the effectiveness of emotion regulation training on depression and emotion regulation strategies of pediatric type I diabetes. \u0000Materials and Methods: The study used a quasi-experimental approach that included pre-and post-test assessments to compare the experimental and control groups. The University of Medical Sciences in Shiraz, provided services to a total of 30 patients. Patients were chosen using purposive sampling and were randomly allocated to either the experimental group (n=15) or the control group (n=15) Pediatric types I diabetes. The Beck Depression Inventory (BDI-II) and the Gross and John Emotion Regulation Questionnaire were used to collecting data. The experimental group got eight training sessions on depression and emotional regulation (once a week for two months), whereas the control group got no instruction. The data was analyzed using an analysis of covariance by SPSS.23. \u0000Results: The mean (±SD) of age in the experimental group and control groups were determined to be 14.60 (±0.88) and 14.46 (±073) years, respectively. According to the results, emotion regulation training had a significant effect in decreasing depression and increasing the adaptive emotional regulation strategies in students (P> 0.001). \u0000Conclusion: Emotion regulation training might be a useful strategy for improving emotion regulation difficulties in patients with type I diabetes, according to the findings of this investigation, although the efficacy of emotion regulation training was not approved in this investigation due to a lack of intervention factors.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43640742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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