Objective: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in childhood, and its management is associated with many problems. The study aimed to compare the effect of group self-care training and patient child play (PCP) on quality of life (QoL) in children with type 1 diabetes in Isfahan, Iran Materials and Methods: This randomized trial was done from January 2020 to October 2021 in Endocrine and Metabolism research center of Isfahan University of medical sciences. Seventy- five children aged 8 to 11 years with T1DM who did not have a severe behavioral problem based on the child behavior checklist (CBCL) were simple randomly assigned to three groups: self-care training, play therapy, and control. The self-care group received ten education sessions via the Skyroom and the playgroup performed PCP for ten sessions. The control group did not receive any psychological intervention. All participants received routine diabetes medication. They completed a health-related QoL questionnaire for children (KIDSCREEN-52) before and after the intervention. Data were analyzed using SPSS-23 software and analysis of covariance. Results: A significant difference between the mean scores of the post-test subscales of physical well-being (P= 0.003), psychological well-being (P= 0.003), moods and emotions (P= 0.02), self-perception (P= 0.002), self-autonomy (P= 0.002), parental relationships and family life (P= 0.001), social and peers support (P= 0.04), school environment (P= 0.003) and social acceptance (P= 0.001) in PCP group. Conclusion: Self-care training and PCP are effective in increasing the QoL, and can be used as a complementary treatment in children with T1DM.
{"title":"Comparing the Effect of Internet-Delivered Self-Care Training and Play Therapy on the Quality of Life of Children with Type 1 diabetes in 2021 in Isfahan City- Randomized Clinical Trial","authors":"Fatemeh Zargar, Ailin Salmani, Neda Mostofizadeh, Reza Bagherian Sararoodi, Zahra Heydari","doi":"10.18502/ijdo.v15i4.14555","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14555","url":null,"abstract":"Objective: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in childhood, and its management is associated with many problems. The study aimed to compare the effect of group self-care training and patient child play (PCP) on quality of life (QoL) in children with type 1 diabetes in Isfahan, Iran Materials and Methods: This randomized trial was done from January 2020 to October 2021 in Endocrine and Metabolism research center of Isfahan University of medical sciences. Seventy- five children aged 8 to 11 years with T1DM who did not have a severe behavioral problem based on the child behavior checklist (CBCL) were simple randomly assigned to three groups: self-care training, play therapy, and control. The self-care group received ten education sessions via the Skyroom and the playgroup performed PCP for ten sessions. The control group did not receive any psychological intervention. All participants received routine diabetes medication. They completed a health-related QoL questionnaire for children (KIDSCREEN-52) before and after the intervention. Data were analyzed using SPSS-23 software and analysis of covariance. Results: A significant difference between the mean scores of the post-test subscales of physical well-being (P= 0.003), psychological well-being (P= 0.003), moods and emotions (P= 0.02), self-perception (P= 0.002), self-autonomy (P= 0.002), parental relationships and family life (P= 0.001), social and peers support (P= 0.04), school environment (P= 0.003) and social acceptance (P= 0.001) in PCP group. Conclusion: Self-care training and PCP are effective in increasing the QoL, and can be used as a complementary treatment in children with T1DM.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"266 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18502/ijdo.v15i4.14558
Mohammad Mehdi Hakimian, N. Sedrpoushan, F. A. Shahreza
Objective: The purpose of this study was to investigate the effectiveness of acceptance and commitment based group therapy (ACT) with the Islamic approach to reduce anxiety and depression in patients with type II diabetes referent to the Yazd Diabetes Research Center. Materials and Methods: The study method was the semi experimental. Forty diabetic patients were simple randomly divided into two equal experimental and control groups. The study was done in the patients referent to the Yazd diabetes center (n= 5000), using a purposeful sampling method. So, all of the patients did completed the beck anxiety (BAI) and depression (BDI-II) questionnaire for diabetic patients. Then, the experimental group received ACT with an Islamic approach every other week during 16 weeks and 120 minutes for each time, and the control group continued their normal plan. The population of both groups performed the anxiety (BAI) and depression (BDI-II) questionnaire again after performing the instructional plan. Results: In this research, the covariance analysis test was used to analyze the results. The findings of the research showed that ACT with an Islamic approach effects on the anxiety (P: 0.001) and depression (P: 0.001) in type II diabetes people. Conclusion: The results showed that ACT with Islamic approach is effective on reducing anxiety rate and depression of type 2 diabetic people. Scores of post-test confirmed the effect of treatment method ACT with Islamic approach on reducing of anxiety and depression rate.
研究目的本研究旨在探讨亚兹德糖尿病研究中心的 II 型糖尿病患者接受和承诺团体疗法 (ACT) 与伊斯兰疗法在减轻焦虑和抑郁方面的有效性。 材料与方法：研究方法为半实验法。40 名糖尿病患者被简单随机地分为两个相等的实验组和对照组。研究在亚兹德糖尿病研究中心的病人（5000 人）中进行，采用有目的的抽样方法。因此，所有患者都填写了针对糖尿病患者的贝克焦虑（BAI）和抑郁（BDI-II）问卷。然后，实验组在 16 周内每隔一周接受一次伊斯兰方法的 ACT 治疗，每次 120 分钟，对照组则继续执行正常计划。两组人群在执行指导计划后再次进行焦虑（BAI）和抑郁（BDI-II）问卷调查。 研究结果本研究采用协方差分析检验法对结果进行分析。研究结果表明，采用伊斯兰方法的 ACT 对 II 型糖尿病患者的焦虑（P: 0.001）和抑郁（P: 0.001）有影响。 结论研究结果表明，采用伊斯兰方法的 ACT 能有效降低 II 型糖尿病患者的焦虑率和抑郁率。后测得分证实了伊斯兰法 ACT 治疗方法对降低焦虑率和抑郁率的效果。
{"title":"Effectiveness of Acceptance and Commitment Group Therapy with the Islamic Approach to Reduce Anxiety and Depression in Type II Diabetes People in Yazd","authors":"Mohammad Mehdi Hakimian, N. Sedrpoushan, F. A. Shahreza","doi":"10.18502/ijdo.v15i4.14558","DOIUrl":"https://doi.org/10.18502/ijdo.v15i4.14558","url":null,"abstract":"Objective: The purpose of this study was to investigate the effectiveness of acceptance and commitment based group therapy (ACT) with the Islamic approach to reduce anxiety and depression in patients with type II diabetes referent to the Yazd Diabetes Research Center. Materials and Methods: The study method was the semi experimental. Forty diabetic patients were simple randomly divided into two equal experimental and control groups. The study was done in the patients referent to the Yazd diabetes center (n= 5000), using a purposeful sampling method. So, all of the patients did completed the beck anxiety (BAI) and depression (BDI-II) questionnaire for diabetic patients. Then, the experimental group received ACT with an Islamic approach every other week during 16 weeks and 120 minutes for each time, and the control group continued their normal plan. The population of both groups performed the anxiety (BAI) and depression (BDI-II) questionnaire again after performing the instructional plan. Results: In this research, the covariance analysis test was used to analyze the results. The findings of the research showed that ACT with an Islamic approach effects on the anxiety (P: 0.001) and depression (P: 0.001) in type II diabetes people. Conclusion: The results showed that ACT with Islamic approach is effective on reducing anxiety rate and depression of type 2 diabetic people. Scores of post-test confirmed the effect of treatment method ACT with Islamic approach on reducing of anxiety and depression rate.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"33 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.18502/ijdo.v15i3.13735
Zahra Razavi, Pegah Ammeri
Objective: Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of insulin-producing beta cells of the pancreas. The objective of the present study was to describe the one year (2019-2020) incidence of T1DM in Hamadan west region of Iran.
Materials and Methods: All 25 new patients with T1DM resident of Hamadan and its suburbs registered in Besat Hospital, Hamadan, Iran, from March 2019 to 2020 were prospectively reviewed. Information including age, sex, place of residence (urban or rural), season of diagnosis and season of birth were taken from parents through face-to-face interviews.
Results: During 1 year survey, a total of 57 cases of newly diagnosed T1DM were identified in our center. Among these, 25 patients were residents of Hamadan city and suburbs. Based on this15 per 100 000 per year new cases T1DM occurred in the resident population of Hamadan areas, higher in boys than in girls (18 vs. 11 per 100 000).The mean age of diagnosis was 8.03 yr. The peak incidence was observed at the age group of 10- 14 years. 92% were urban .Most cases were diagnosed in the autumn (44%). 52% had a history of neonatal jaundice and 16% had stressful life events in the family before the onset of diabetes.
Conclusion: Our study showed a relatively high incidence of T1DM according category of the WHO, being greater in boys and in the age group of 10 to 14 years. The incidence is lower than in some Middle Eastern countries.
{"title":"Incidence of Type 1 Diabetes Mellitus in Hamadan West Region of Iran2019 - 2020","authors":"Zahra Razavi, Pegah Ammeri","doi":"10.18502/ijdo.v15i3.13735","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13735","url":null,"abstract":"Objective: Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of insulin-producing beta cells of the pancreas. The objective of the present study was to describe the one year (2019-2020) incidence of T1DM in Hamadan west region of Iran.
 Materials and Methods: All 25 new patients with T1DM resident of Hamadan and its suburbs registered in Besat Hospital, Hamadan, Iran, from March 2019 to 2020 were prospectively reviewed. Information including age, sex, place of residence (urban or rural), season of diagnosis and season of birth were taken from parents through face-to-face interviews.
 Results: During 1 year survey, a total of 57 cases of newly diagnosed T1DM were identified in our center. Among these, 25 patients were residents of Hamadan city and suburbs. Based on this15 per 100 000 per year new cases T1DM occurred in the resident population of Hamadan areas, higher in boys than in girls (18 vs. 11 per 100 000).The mean age of diagnosis was 8.03 yr. The peak incidence was observed at the age group of 10- 14 years. 92% were urban .Most cases were diagnosed in the autumn (44%). 52% had a history of neonatal jaundice and 16% had stressful life events in the family before the onset of diabetes.
 Conclusion: Our study showed a relatively high incidence of T1DM according category of the WHO, being greater in boys and in the age group of 10 to 14 years. The incidence is lower than in some Middle Eastern countries.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.18502/ijdo.v15i3.13737
Mohammad Torkashvand Moradabadi, Sedigheh Hannani, Zahra Torkashvand
Objective: The epidemiological transition and the increase of chronic diseases resulted in the rise of endocrine, nutritional and metabolic (ENM) diseases as causes of death. This study aimed to explore the death rate caused by ENM in Iran 2006-18.
Materials and Methods: Secondary data analysis was done. The demographic data on death were extracted (age, sex and cause of death) at the provincial level from the death records registered by civil registration. The conditions and trends of ENM death were analyzed from 2006 to 2018. The differences were analyzed in terms of age, sex, place of residence, and over time through indicators of death rate, sex ratio, and years of life lost (YLL).
Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P: <0.001), weight (P: <0.001), number of pregnancies (P: <0.001), delivery (P: <0.001), previous diseases (P: <0.001), and Rh (P: 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed.
Conclusion: 6,906 people were died in Iran between 2006- 2018 due to ENM diseases. The death rate from this disease increased from 3.5 per 100,000 people in 2006 to 8.4 in 2018. More women died, especially in old age, with the peak of death being at the age of 50 and older. ENM death resulted in the loss of 67,041 years of life.
{"title":"Epidemilogic Study of Death Caused by Endocrine, Nutritional, and Metabolic Diseases in Iran During 2006-2018","authors":"Mohammad Torkashvand Moradabadi, Sedigheh Hannani, Zahra Torkashvand","doi":"10.18502/ijdo.v15i3.13737","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13737","url":null,"abstract":"Objective: The epidemiological transition and the increase of chronic diseases resulted in the rise of endocrine, nutritional and metabolic (ENM) diseases as causes of death. This study aimed to explore the death rate caused by ENM in Iran 2006-18.
 Materials and Methods: Secondary data analysis was done. The demographic data on death were extracted (age, sex and cause of death) at the provincial level from the death records registered by civil registration. The conditions and trends of ENM death were analyzed from 2006 to 2018. The differences were analyzed in terms of age, sex, place of residence, and over time through indicators of death rate, sex ratio, and years of life lost (YLL).
 Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P: <0.001), weight (P: <0.001), number of pregnancies (P: <0.001), delivery (P: <0.001), previous diseases (P: <0.001), and Rh (P: 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed.
 Conclusion: 6,906 people were died in Iran between 2006- 2018 due to ENM diseases. The death rate from this disease increased from 3.5 per 100,000 people in 2006 to 8.4 in 2018. More women died, especially in old age, with the peak of death being at the age of 50 and older. ENM death resulted in the loss of 67,041 years of life.
","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135198885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.18502/ijdo.v15i3.13738
Fatima Qureshi, Haji Khan Khoharo
Objective: The aim of this study was to determine and correlate the serum chromium in Carotid intima - media thickness (CIMT) in type 2 Diabetes Mellitus (T2DM) subjects.
Materials and Methods: The present case – control study included 40 healthy controls and 45 T2DM subjects that were selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum chromium (Cr) was detected and measured on inductively coupled “Plasma Optical Emission Spectrophotometer” (ICP- OES)- Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed by Student’s t test and Chi square test in the SPSS 22.0 (USA). Linear regression model was used for predicting carotid intima media thickness. Level of confidence interval of statistical significance was 95% (P≤ 0.05).
Results: Serum Cr in controls and cases was noted 0.873 (± 0.162) and 0.281 (± 0.240) µg/ml (P= 0.001). Serum Cr proved negative correlation with random blood sugar (r= -0.145, P= 0.185), HbA1c (r= -0.145, P= 0.0001) and CIMT (r= -0.730, P= 0.0001). Multiple regression analysis model showed significant association of serum Cr (r= -0.730, P< 0.0001) and HbA1c (r= 0.754, P< 0.0001) with the CIMT.
Conclusion: The present study reported serum Cr was inversely correlated with the carotid intima - media thickness that is a marker of atherosclerosis. Cr supplements may be advised to diabetics in clinical management.
{"title":"Serum Chromium is Inversely Correlated with the Carotid Intima– Media Thickness in Type 2 Diabetic Subjects","authors":"Fatima Qureshi, Haji Khan Khoharo","doi":"10.18502/ijdo.v15i3.13738","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13738","url":null,"abstract":"Objective: The aim of this study was to determine and correlate the serum chromium in Carotid intima - media thickness (CIMT) in type 2 Diabetes Mellitus (T2DM) subjects.
 Materials and Methods: The present case – control study included 40 healthy controls and 45 T2DM subjects that were selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum chromium (Cr) was detected and measured on inductively coupled “Plasma Optical Emission Spectrophotometer” (ICP- OES)- Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed by Student’s t test and Chi square test in the SPSS 22.0 (USA). Linear regression model was used for predicting carotid intima media thickness. Level of confidence interval of statistical significance was 95% (P≤ 0.05).
 Results: Serum Cr in controls and cases was noted 0.873 (± 0.162) and 0.281 (± 0.240) µg/ml (P= 0.001). Serum Cr proved negative correlation with random blood sugar (r= -0.145, P= 0.185), HbA1c (r= -0.145, P= 0.0001) and CIMT (r= -0.730, P= 0.0001). Multiple regression analysis model showed significant association of serum Cr (r= -0.730, P< 0.0001) and HbA1c (r= 0.754, P< 0.0001) with the CIMT.
 Conclusion: The present study reported serum Cr was inversely correlated with the carotid intima - media thickness that is a marker of atherosclerosis. Cr supplements may be advised to diabetics in clinical management.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.18502/ijdo.v15i3.13739
Seyed Hamid Akhlaghi
Objective: This study aimed to conduct a systematic review about diabetes mellitus and COVID-19 severity, management, and mortality
Materials and Methods: Thirteen studies were included in this review, comprising a total of 1155 COVID-19 patients with diabetes mellitus as a significant comorbidity. Data regarding patient demographics and the prevalence of comorbidities, including smoking, hypertension, cardiovascular disease, chronic kidney disease, and chronic liver disease, were collected.
Results: Among COVID-19 patients with diabetes mellitus, the majority were male (57.1%) compared to females (42.9%). The prevalence of comorbidities in COVID-19 are varied, with smokers accounting for 1- 12.6%, hypertension ranging from 8-41.6%, diabetes mellitus ranging from 7.4-70.8%, cardiovascular disease ranging from 1.6-23.0%, chronic kidney disease ranging from 0.7-2.9%, and chronic liver disease ranging from 0.5-4.6%. In comparison to COVID-19 patients without diabetes, a higher proportion of patients with diabetes mellitus were admitted to the intensive care unit (36.8%). Among COVID-19 patients with diabetes mellitus, the survival rate was significantly higher at 62.2% compared to a lower rate of 13.4% observed among non-survivors with diabetes mellitus.
Conclusion: This systematic review emphasizes the significance of diabetes mellitus as a comorbidity in COVID-19 patients, increasing the risk of ICU admission. These findings emphasize the importance of identifying and effectively managing diabetes mellitus as a comorbidity in COVID-19 patients to enhance overall outcomes.
{"title":"Diabetes Mellitus and COVID-19: Prevalence, Severity, Management, and Mortality: A Secondary Study","authors":"Seyed Hamid Akhlaghi","doi":"10.18502/ijdo.v15i3.13739","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13739","url":null,"abstract":"Objective: This study aimed to conduct a systematic review about diabetes mellitus and COVID-19 severity, management, and mortality
 Materials and Methods: Thirteen studies were included in this review, comprising a total of 1155 COVID-19 patients with diabetes mellitus as a significant comorbidity. Data regarding patient demographics and the prevalence of comorbidities, including smoking, hypertension, cardiovascular disease, chronic kidney disease, and chronic liver disease, were collected.
 Results: Among COVID-19 patients with diabetes mellitus, the majority were male (57.1%) compared to females (42.9%). The prevalence of comorbidities in COVID-19 are varied, with smokers accounting for 1- 12.6%, hypertension ranging from 8-41.6%, diabetes mellitus ranging from 7.4-70.8%, cardiovascular disease ranging from 1.6-23.0%, chronic kidney disease ranging from 0.7-2.9%, and chronic liver disease ranging from 0.5-4.6%. In comparison to COVID-19 patients without diabetes, a higher proportion of patients with diabetes mellitus were admitted to the intensive care unit (36.8%). Among COVID-19 patients with diabetes mellitus, the survival rate was significantly higher at 62.2% compared to a lower rate of 13.4% observed among non-survivors with diabetes mellitus.
 Conclusion: This systematic review emphasizes the significance of diabetes mellitus as a comorbidity in COVID-19 patients, increasing the risk of ICU admission. These findings emphasize the importance of identifying and effectively managing diabetes mellitus as a comorbidity in COVID-19 patients to enhance overall outcomes.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.18502/ijdo.v15i3.13740
Mohammad Hossein Ghofrani, Alireza Rahimi, Eidi Alijani, Foad Feizolahi
Objective: In the last two decades, genetic studies have strongly supported the effective role of genetic factors on the synthesis of insulin from the pancreas. The purpose of this research is to determine the effect of aerobic and resistance exercises on the expression of NeruoD1 and PDX1 in pancreatic tissue, as well as serum insulin and glucose levels in type 2 diabetic rats.
Materials and Methods: 21 male wistar rats (220±10 g) were included. Then diabetic rats were randomly assigned into 3 groups: 1) control (no-training), 2) resistance training and 3) aerobic training. Exercise training lasted 10 weeks and 5 times weekly for training groups. After intervention, NeruoD1 and PDX1 expression in pancreas, insulin and glucose were compared between groups. Data compared by one way ANOVA and Tukey's post hoc test between groups (P < 0.05).
Results: Compared to control rats, resistance and aerobic training led to significant increase in serum insulin (P: 0.001, P: 0.013 respectively), PDX1 expression (P: 0.001, P: 0.001 respectively) and decrease glucose (P: 0.001, P: 0.001 respectively). Significant difference was not observed between control and aerobic groups with regard to NeruoD1 expression (P: 0.077). In addition, NeruoD1 expression in resistance group was significantly higher than aerobic and control groups (P: 0.018, P: 0.001, respectively).
Conclusion: Despite the improvement of insulin and glucose in response to both aerobic and resistance training, it seems that resistance training affects genes affecting insulin synthesis and transcription more than aerobic training
{"title":"The Impact of Resistance and Aerobic Training on the Insulin Synthesis Genes Expression in Diabetic Rats","authors":"Mohammad Hossein Ghofrani, Alireza Rahimi, Eidi Alijani, Foad Feizolahi","doi":"10.18502/ijdo.v15i3.13740","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13740","url":null,"abstract":"Objective: In the last two decades, genetic studies have strongly supported the effective role of genetic factors on the synthesis of insulin from the pancreas. The purpose of this research is to determine the effect of aerobic and resistance exercises on the expression of NeruoD1 and PDX1 in pancreatic tissue, as well as serum insulin and glucose levels in type 2 diabetic rats.
 Materials and Methods: 21 male wistar rats (220±10 g) were included. Then diabetic rats were randomly assigned into 3 groups: 1) control (no-training), 2) resistance training and 3) aerobic training. Exercise training lasted 10 weeks and 5 times weekly for training groups. After intervention, NeruoD1 and PDX1 expression in pancreas, insulin and glucose were compared between groups. Data compared by one way ANOVA and Tukey's post hoc test between groups (P < 0.05).
 Results: Compared to control rats, resistance and aerobic training led to significant increase in serum insulin (P: 0.001, P: 0.013 respectively), PDX1 expression (P: 0.001, P: 0.001 respectively) and decrease glucose (P: 0.001, P: 0.001 respectively). Significant difference was not observed between control and aerobic groups with regard to NeruoD1 expression (P: 0.077). In addition, NeruoD1 expression in resistance group was significantly higher than aerobic and control groups (P: 0.018, P: 0.001, respectively).
 Conclusion: Despite the improvement of insulin and glucose in response to both aerobic and resistance training, it seems that resistance training affects genes affecting insulin synthesis and transcription more than aerobic training","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Today, the association of blood groups as genetic traits has been confirmed in many diseases. However, its association with gestational diabetes mellitus (GDM) has not been investigated. Therefore, in this study, we investigated the relationship between blood groups and GDM.
Materials and Methods: In this analytical cross-sectional study, pregnant women referred to Baqaeipur Clinic and Yazd Diabetes Research Center in 2015-2018Based on the information related to the results of the onehour OGTT test and the two-hour glucose levels recorded in the file were divided into two groups (GDM, non GDM). Then other information about the participants in the study, including demographic information, medical history, ABO and Rh blood groups, abortion, delivery, and number of pregnancies were extracted from the file and analyzed using SPSS version 23 software.
Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed.
Conclusion: Finally, we concluded that the frequency of the B+ blood group is higher in the GDM group, however, there is no statistically significant relationship between ABO blood groups and GDM.
{"title":"Association of ABO ,Rh Blood Groups with the Susceptibility of Gestational Diabetes in the Yazd-Iran Population","authors":"Afsaneh Khojastepor, Reyhaneh Azizi, Razieh Sadat Tabatabaei, Nasim Namiranian, Haniyeh Nikkhah","doi":"10.18502/ijdo.v15i3.13736","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13736","url":null,"abstract":"Objective: Today, the association of blood groups as genetic traits has been confirmed in many diseases. However, its association with gestational diabetes mellitus (GDM) has not been investigated. Therefore, in this study, we investigated the relationship between blood groups and GDM.
 Materials and Methods: In this analytical cross-sectional study, pregnant women referred to Baqaeipur Clinic and Yazd Diabetes Research Center in 2015-2018Based on the information related to the results of the onehour OGTT test and the two-hour glucose levels recorded in the file were divided into two groups (GDM, non GDM). Then other information about the participants in the study, including demographic information, medical history, ABO and Rh blood groups, abortion, delivery, and number of pregnancies were extracted from the file and analyzed using SPSS version 23 software.
 Results: Out of 1708 pregnant women, 244 (14.3%) had GDM, and 1464 (85.7%) did not. There was a statistically significant difference between these two groups in terms of age (P< 0.001), weight (P< 0.001), number of pregnancies (P< 0.001), delivery (P< 0.001), previous diseases (P< 0.001), and Rh (P= 0.01). While in terms of the ABO blood group system (P= 0.3) and abortion rate (P= 0.067), no statistically significant difference was observed.
 Conclusion: Finally, we concluded that the frequency of the B+ blood group is higher in the GDM group, however, there is no statistically significant relationship between ABO blood groups and GDM.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.18502/ijdo.v15i3.13733
Mohammad Ebrahim Bahram, Roghayyeh Afroundeh, Mohammad Javad Pourvaghar, Farnaz Seify Skishahr, Leila Katebi, Ozkan Isik
Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM).
Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes.
Results: The results showed that the amount of salusin-β and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-α increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-β and interleukin 6 were lower (P= 0.001), and the level of salusin-α was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups.
Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.
{"title":"The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men","authors":"Mohammad Ebrahim Bahram, Roghayyeh Afroundeh, Mohammad Javad Pourvaghar, Farnaz Seify Skishahr, Leila Katebi, Ozkan Isik","doi":"10.18502/ijdo.v15i3.13733","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13733","url":null,"abstract":"Objective: This study aimed to investigate the effect of 8 weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type 2 diabetes mellitus (T2DM).
 Materials and Methods: 40 elderly men T2DM aged between 65 to 70 years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of 1000 mg Mulberry leaf extract, 3 times a day, was used for 2 months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of 90 minutes.
 Results: The results showed that the amount of salusin-β and interleukin-6 in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-α increased significantly in the training (P= 0.001), training + supplement (P= 0.001) and supplement (P= 0.01) groups. Also, the results of the covariance analysis showed that the amount of salusin-β and interleukin 6 were lower (P= 0.001), and the level of salusin-α was higher significantly in the training (P= 0.001), training +supplement (P= 0.001), and supplement (P= 0.001) groups compared to the control groups.
 Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T2DM elderly.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.18502/ijdo.v15i3.13734
Neşe KOÇAKGÖL, Meryem KILIÇ
Objective: Determining diabetic foot risk levels and risk factors and treating foot problems is one of the main components of the prevention of diabetic foot ulcers (DFU). This study aimed to determine diabetic foot risk levels and risk factors in diabetic people.
Materials and Methods: This descriptive cross-sectional study included 278 participants during September 2020 to March 2021. The patients' general characteristics, peripheral sensory loss (10 g-Semmes-Weinstein monofilament), foot skin temperature (palpation method) and vascular evaluation (pedal pulses) were examined.
Results: Among 278 patients, 83 cases had DFU. Of those without DFU, 33.3% had risk level “0”, 35.4% had risk level “1”, 23.6% had risk level “2” and 7.7% had risk level “3”. In the regression analysis, male gender [OR= 0.74, 95% CI (0.014-0.338), P= 0.002], education (literate) [OR= 0.38, 95% CI (0.002-0.630), P= 0.022], foot examination by health professional [OR= 0.013, 95% CI (0.001-0.183), P= 0.001], foot deformity [OR= 0.170, 95% CI (0.042-0.679), P< 0.001], foot skin temperature (cold) [OR= 0.003, 95% CI (0.000– 0.026), P< 0.001], and pedal pulse [OR= 8.146, 95% CI (1.505-44.081), P< 0.015] were found to have a high effect on diabetic foot development.
Conclusion: The annual DFU rate is 29.8%. Independent risk factors of DFU were gender, education, previous history foot examination, foot skin temperature, pedal pulse and foot deformity. These findings provide support for a multifactorial etiology for DFU.
目的:确定糖尿病足的危险水平和危险因素，治疗足部问题是预防糖尿病足溃疡(DFU)的主要组成部分之一。本研究旨在确定糖尿病患者糖尿病足的危险水平和危险因素。
材料和方法:这项描述性横断面研究包括278名参与者，时间为2020年9月至2021年3月。检查患者的一般特征、外周感觉丧失(10 g-Semmes-Weinstein单丝)、足部皮肤温度(触诊法)和血管评估(脚脉冲)。
结果:278例患者中，83例发生DFU。无DFU者风险等级为0级的占33.3%，风险等级为1级的占35.4%，风险等级为2级的占23.6%，风险等级为3级的占7.7%。在回归分析中，男性[OR= 0.74, 95% CI (0.014-0.338)， P= 0.002]，教育程度(识字)[OR= 0.38, 95% CI (0.002-0.630)， P= 0.022]，卫生专业人员足部检查[OR= 0.013, 95% CI (0.001-0.183)， P= 0.001]，足部畸形[OR= 0.170, 95% CI (0.042-0.679)， P<0.001]，足部皮肤温度(冷)[OR= 0.003, 95% CI (0.000 - 0.026)， P<0.001]，踏板脉搏[OR= 8.146, 95% CI (1.505-44.081)， P<0.015]对糖尿病足的发展有很高的影响。
结论:年DFU率为29.8%。DFU的独立危险因素为性别、文化程度、既往足部检查史、足部皮肤温度、足脉、足部畸形。这些发现为DFU的多因素病因学提供了支持。
{"title":"Diabetic Foot Risk Factors & level in Diabetes People: A Cross-Sectional Study","authors":"Neşe KOÇAKGÖL, Meryem KILIÇ","doi":"10.18502/ijdo.v15i3.13734","DOIUrl":"https://doi.org/10.18502/ijdo.v15i3.13734","url":null,"abstract":"Objective: Determining diabetic foot risk levels and risk factors and treating foot problems is one of the main components of the prevention of diabetic foot ulcers (DFU). This study aimed to determine diabetic foot risk levels and risk factors in diabetic people.
 Materials and Methods: This descriptive cross-sectional study included 278 participants during September 2020 to March 2021. The patients' general characteristics, peripheral sensory loss (10 g-Semmes-Weinstein monofilament), foot skin temperature (palpation method) and vascular evaluation (pedal pulses) were examined.
 Results: Among 278 patients, 83 cases had DFU. Of those without DFU, 33.3% had risk level “0”, 35.4% had risk level “1”, 23.6% had risk level “2” and 7.7% had risk level “3”. In the regression analysis, male gender [OR= 0.74, 95% CI (0.014-0.338), P= 0.002], education (literate) [OR= 0.38, 95% CI (0.002-0.630), P= 0.022], foot examination by health professional [OR= 0.013, 95% CI (0.001-0.183), P= 0.001], foot deformity [OR= 0.170, 95% CI (0.042-0.679), P< 0.001], foot skin temperature (cold) [OR= 0.003, 95% CI (0.000– 0.026), P< 0.001], and pedal pulse [OR= 8.146, 95% CI (1.505-44.081), P< 0.015] were found to have a high effect on diabetic foot development.
 Conclusion: The annual DFU rate is 29.8%. Independent risk factors of DFU were gender, education, previous history foot examination, foot skin temperature, pedal pulse and foot deformity. These findings provide support for a multifactorial etiology for DFU.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"221 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135198884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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