E. Moradi, M. Sabeti, N. Shahbazi, Z. Habibi, F. Nejat
Background: Shunt Infection is a common complication of shunt insertion in children which can lead to bad neuro-developmental conditions and impose a considerable economic burden for the health care system. So, identifying predictive factors of shunt infection could help us in the proper improvement of this deteriorating condition. Methods: In this study, related risk factors of 68 patients with history of shunt infection and 80 matched controls without any history of shunt infection, who were all operated in a single referral hospital were assessed. Three machine learning (ML)-based measures including sparsity, correlation, and redundancy along with specialist’s score were applied to select the most important predictive risk factors for shunt infection. ML was determined by summation of sparsity, correlation and redundancy measures, and the final total score was considered as normalization (ML-based score + specialist score). Results: According to the total score, prematurity, first ventriculoperitoneal shunting (VPS) age, intraventricular hemorrhage (IVH), myelomeningocele (MMC) and low birth weight had higher weights as shunt infection risk factors. icterus, trauma, co-infection and tumor had the lowest weights and history of meningitis and number of shunt revisions were defined as intermediate risk factors. Conclusion: The "ML-based clinical adjusted" method may be used as a complementary tool to help neurosurgeons in better patient selection and more accurate follow-up of children with higher risk of shunt infection.
{"title":"Machine Learning-Based Clinical Adjusted Selection of Predicting Risk Factors for Shunt Infection in Children","authors":"E. Moradi, M. Sabeti, N. Shahbazi, Z. Habibi, F. Nejat","doi":"10.34172/icnj.2021.28","DOIUrl":"https://doi.org/10.34172/icnj.2021.28","url":null,"abstract":"Background: Shunt Infection is a common complication of shunt insertion in children which can lead to bad neuro-developmental conditions and impose a considerable economic burden for the health care system. So, identifying predictive factors of shunt infection could help us in the proper improvement of this deteriorating condition. Methods: In this study, related risk factors of 68 patients with history of shunt infection and 80 matched controls without any history of shunt infection, who were all operated in a single referral hospital were assessed. Three machine learning (ML)-based measures including sparsity, correlation, and redundancy along with specialist’s score were applied to select the most important predictive risk factors for shunt infection. ML was determined by summation of sparsity, correlation and redundancy measures, and the final total score was considered as normalization (ML-based score + specialist score). Results: According to the total score, prematurity, first ventriculoperitoneal shunting (VPS) age, intraventricular hemorrhage (IVH), myelomeningocele (MMC) and low birth weight had higher weights as shunt infection risk factors. icterus, trauma, co-infection and tumor had the lowest weights and history of meningitis and number of shunt revisions were defined as intermediate risk factors. Conclusion: The \"ML-based clinical adjusted\" method may be used as a complementary tool to help neurosurgeons in better patient selection and more accurate follow-up of children with higher risk of shunt infection.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48168246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samaneh Shakeri, R. Bidaki, H. Mirhosseini, Mina Kiani
Background: Some experts assert there is an association between traumatic brain injury and cognitive impairments such as attention deficit hyperactivity disorder (ADHD) and depressive disorder. Furthermore, children and adults with ADHD struggle with focusing, organizing tasks, and feeling restless. They might experience sadness, guilt, irritability, low self-confidence and helplessness. In this regard, ADHD and depressive disorder occasionally occur together. We aimed to compare the clinical application of the Bender-Gestalt test (BGT) and electroencephalography in screening brain damage in the patients with the mentioned disorders. Methods: This was a cross-sectional study to assess diagnostic accuracy. Eighty patients with depression (n=35) and ADHD (n=45) resulting from brain damage aged 10-35 years who had been referred by the psychologist or psychiatrist to Imam Hossein Clinic in Yazd. Both the BGT and quantitative electroencephalography (QEEG) results existed in their files. Patients with any serious medical, other psychiatric disorders or history of drug dependency were excluded. Paired t test was used to analyze the differences. Results: The brain damage score was different in the two tests. Based on the paired t test, the BGT was a more valid screening test. Also, the score of the two tests were different in the depression and ADHD mean scores (P<0.05). Conclusion: BGT was a more reliable tool compared to QEEG for diagnosing brain damage within the patients with the mentioned disorders.
{"title":"Comparing Bender-Gestalt Test and Quantitative Electroencephalography for Brain Trauma Diagnosis in Depressive and Attention Deficit Hyperactivity Disorders","authors":"Samaneh Shakeri, R. Bidaki, H. Mirhosseini, Mina Kiani","doi":"10.34172/icnj.2021.29","DOIUrl":"https://doi.org/10.34172/icnj.2021.29","url":null,"abstract":"Background: Some experts assert there is an association between traumatic brain injury and cognitive impairments such as attention deficit hyperactivity disorder (ADHD) and depressive disorder. Furthermore, children and adults with ADHD struggle with focusing, organizing tasks, and feeling restless. They might experience sadness, guilt, irritability, low self-confidence and helplessness. In this regard, ADHD and depressive disorder occasionally occur together. We aimed to compare the clinical application of the Bender-Gestalt test (BGT) and electroencephalography in screening brain damage in the patients with the mentioned disorders. Methods: This was a cross-sectional study to assess diagnostic accuracy. Eighty patients with depression (n=35) and ADHD (n=45) resulting from brain damage aged 10-35 years who had been referred by the psychologist or psychiatrist to Imam Hossein Clinic in Yazd. Both the BGT and quantitative electroencephalography (QEEG) results existed in their files. Patients with any serious medical, other psychiatric disorders or history of drug dependency were excluded. Paired t test was used to analyze the differences. Results: The brain damage score was different in the two tests. Based on the paired t test, the BGT was a more valid screening test. Also, the score of the two tests were different in the depression and ADHD mean scores (P<0.05). Conclusion: BGT was a more reliable tool compared to QEEG for diagnosing brain damage within the patients with the mentioned disorders.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41414192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Eftekharian, Sara Rahmati Roodsari, Zahra Arab-Mazar, M. Rahimi
Toxoplasma gondii is an intracellular parasite that has been associated with several mental disorders. It usually causes an inapparent primary infection. Found worldwide, T. gondii is capable of infecting virtually all warm-blooded animals.1-3Schizophrenia is a neurological disorder characterized with long-term and devastating neuropsychological problems, usually presenting in adolescents or young adults. The disease affects almost 1.1% of the global population including all races and ethnic groups with an equal prevalence in both sexes.1 T. gondii seroprevalence is strongly associated with 12-month generalized anxiety disorder but not with other anxiety, depressive, or alcohol-related disorders. Because of the intracellular nature of some parasites, their treatment and development of new drugs is a major challenge for scientists.4 Recently, the use of nanoparticles and nano-scaffolds has suggested for the treatment of parasitic diseases, although limited research has been done in this regard.5-7
{"title":"Schizophrenia: The Dark Side of Toxoplasmosis","authors":"S. Eftekharian, Sara Rahmati Roodsari, Zahra Arab-Mazar, M. Rahimi","doi":"10.34172/icnj.2021.12","DOIUrl":"https://doi.org/10.34172/icnj.2021.12","url":null,"abstract":"Toxoplasma gondii is an intracellular parasite that has been associated with several mental disorders. It usually causes an inapparent primary infection. Found worldwide, T. gondii is capable of infecting virtually all warm-blooded animals.1-3Schizophrenia is a neurological disorder characterized with long-term and devastating neuropsychological problems, usually presenting in adolescents or young adults. The disease affects almost 1.1% of the global population including all races and ethnic groups with an equal prevalence in both sexes.1 T. gondii seroprevalence is strongly associated with 12-month generalized anxiety disorder but not with other anxiety, depressive, or alcohol-related disorders. Because of the intracellular nature of some parasites, their treatment and development of new drugs is a major challenge for scientists.4 Recently, the use of nanoparticles and nano-scaffolds has suggested for the treatment of parasitic diseases, although limited research has been done in this regard.5-7","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45223116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Pir Hayati, Navid Eydivandi, Mehran Khodashenas, Hamid Fallah Torbeh Bar
Background: Parkinson’s disease is a chronic and progressive disease in which patients show symptoms of psychiatric diseases such as anxiety and depression leading to decreased quality of life. So far, few studies have been done in this field in Iran.Methods: The study is a cross-sectional study that investigates the prevalence of anxiety and depression and their related factors in patients with Parkinson’s disease. In this study, 74 patients with Parkinson’s disease and 74 healthy individuals were evaluated and using by Beck’s Depression and Anxiety Inventories.Results: The prevalence of depression and anxiety in patients with Parkinson’s was 37.83% and 78.38%, respectively. The mean score of depression and anxiety was significantly higher in the patient group (P<0.001). Older age, female sex, a higher level of education and a longer duration of illness were significantly associated with more depression and anxiety (P<0.05). Multiple regression models showed that age was a predictive factor in depression. With respect to anxiety, age and duration of the disease were predictive factors.Conclusion: The severity of depression and anxiety were significantly higher in patients with Parkinson’s disease compared to healthy individuals. Age and duration of the disease play a significant role in predicting the severity of depression and anxiety in such patients.
{"title":"Prevalence of Depression and Anxiety and Related Factors in Patients With Parkinson’s Disease","authors":"Mohammad Pir Hayati, Navid Eydivandi, Mehran Khodashenas, Hamid Fallah Torbeh Bar","doi":"10.34172/icnj.2021.18","DOIUrl":"https://doi.org/10.34172/icnj.2021.18","url":null,"abstract":"Background: Parkinson’s disease is a chronic and progressive disease in which patients show symptoms of psychiatric diseases such as anxiety and depression leading to decreased quality of life. So far, few studies have been done in this field in Iran.Methods: The study is a cross-sectional study that investigates the prevalence of anxiety and depression and their related factors in patients with Parkinson’s disease. In this study, 74 patients with Parkinson’s disease and 74 healthy individuals were evaluated and using by Beck’s Depression and Anxiety Inventories.Results: The prevalence of depression and anxiety in patients with Parkinson’s was 37.83% and 78.38%, respectively. The mean score of depression and anxiety was significantly higher in the patient group (P<0.001). Older age, female sex, a higher level of education and a longer duration of illness were significantly associated with more depression and anxiety (P<0.05). Multiple regression models showed that age was a predictive factor in depression. With respect to anxiety, age and duration of the disease were predictive factors.Conclusion: The severity of depression and anxiety were significantly higher in patients with Parkinson’s disease compared to healthy individuals. Age and duration of the disease play a significant role in predicting the severity of depression and anxiety in such patients.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69815108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thi Phuong Hoai Dinh, Dang Thi Mai, Thi Mai Hung Tran, H. Pham, Vinh Phu Nguyen, T. Nguyen
Background:Frontal meningioma is often asymptomatic but patients might experience psychiatric symptoms. Since symptoms are atypical in giant meningioma, to the best of our knowledge, we present a rare clinical scenario. Case Presentation: A 24-year old female patient with no medical history presented with two months of depressive symptoms, personality changes such as easy irritability, and feelings of frustration and mental depression, as well as forgetfulness and blurred vision. Brain magnetic resonance imaging (MRI) revealed a well-defined markedly enhancing lesion in the left frontal region measuring 65 x 70 x 70 mm with mass effects to the adjacent brain tissue and associated surrounding edema which was pressed to the frontal horn of the lateral ventricle. The patient underwent frontal unilateral craniotomy and excision of the tumor. After surgery, the quality of life was improved. Conclusion: Meningioma with psychiatric symptoms is quite rare. This clinical case helps clinicians avoid missing symptoms and use appropriate management strategies for patients with giant meningiomas.
背景:额叶脑膜瘤通常无症状，但患者可能会出现精神症状。由于巨大脑膜瘤的症状是非典型的，据我们所知，我们提出了一个罕见的临床情况。病例介绍:24岁女性，无病史，表现为抑郁症状2个月，易烦躁、沮丧、精神抑郁等人格改变，健忘、视力模糊。脑磁共振成像(MRI)显示左侧额叶区有一个明确的明显增强的病变，面积为65 x 70 x 70 mm，对邻近脑组织和相关的周围水肿有肿块效应，并压迫到侧脑室额角。患者接受单侧额叶开颅手术及肿瘤切除。术后患者的生活质量得到改善。结论:脑膜瘤伴精神症状相当罕见。本临床病例有助于临床医生避免遗漏症状，并对巨大脑膜瘤患者采取适当的治疗策略。
{"title":"A Giant Frontal Meningioma with Psychiatric Symptoms in a Young Woman: A Case Report","authors":"Thi Phuong Hoai Dinh, Dang Thi Mai, Thi Mai Hung Tran, H. Pham, Vinh Phu Nguyen, T. Nguyen","doi":"10.34172/icnj.2021.21","DOIUrl":"https://doi.org/10.34172/icnj.2021.21","url":null,"abstract":"Background:Frontal meningioma is often asymptomatic but patients might experience psychiatric symptoms. Since symptoms are atypical in giant meningioma, to the best of our knowledge, we present a rare clinical scenario. \u0000Case Presentation: A 24-year old female patient with no medical history presented with two months of depressive symptoms, personality changes such as easy irritability, and feelings of frustration and mental depression, as well as forgetfulness and blurred vision. Brain magnetic resonance imaging (MRI) revealed a well-defined markedly enhancing lesion in the left frontal region measuring 65 x 70 x 70 mm with mass effects to the adjacent brain tissue and associated surrounding edema which was pressed to the frontal horn of the lateral ventricle. The patient underwent frontal unilateral craniotomy and excision of the tumor. After surgery, the quality of life was improved. \u0000Conclusion: Meningioma with psychiatric symptoms is quite rare. This clinical case helps clinicians avoid missing symptoms and use appropriate management strategies for patients with giant meningiomas.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47856575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Akhlaghdoust, Poorya Davoodi, Atousa Hashemi, Farzan Fathalizade, M. Baghani, Fatemeh Kamalipoor, Yasaman Rajaee, Sara Mohammadi Doust, Tooba Ebadi Fard Azar, Faeze Eslami, F. Ghasemi, Mahdi Akhlaghdoost
Background: Mental health is a significant problem in developed and developing countries which influences all aspects of life. We aimed to evaluate the status of Iranian students’ mental health. Methods: This cross-sectional study was performed on 2052 elementary school students located in Tehran, Iran, in September 2018. We used the Census sampling method for sampling and the general health questionnaire comprising 28 items. For statistical analysis SPSS software, version 21 was used. Results: A total of 2052 elementary school students (1373 girls and 679 boys) participated in this study. The mean ± standard deviation (SD) ages of the girls and boys were 14.1±1.7 and 13.9±1.1 years, respectively. The mean ± SD of anxiety, social dysfunction, and depression scores were 7.42±4.92, 7.35±3.33, 6.83±2.26 in the girls and 5.65±3.89, 6.30±3.09, 4.61±1.74 in the boys, respectively. The mean ± SD total scores in boys and girls were 20.48±12.31 and 27.90±14.66, respectively. Conclusion: The mental health status of elementary school students was generally low, especially in male students.
{"title":"Evaluation of Iranian Students’ Mental Health: A Cross-sectional Survey","authors":"M. Akhlaghdoust, Poorya Davoodi, Atousa Hashemi, Farzan Fathalizade, M. Baghani, Fatemeh Kamalipoor, Yasaman Rajaee, Sara Mohammadi Doust, Tooba Ebadi Fard Azar, Faeze Eslami, F. Ghasemi, Mahdi Akhlaghdoost","doi":"10.34172/icnj.2021.16","DOIUrl":"https://doi.org/10.34172/icnj.2021.16","url":null,"abstract":"Background: Mental health is a significant problem in developed and developing countries which influences all aspects of life. We aimed to evaluate the status of Iranian students’ mental health. \u0000Methods: This cross-sectional study was performed on 2052 elementary school students located in Tehran, Iran, in September 2018. We used the Census sampling method for sampling and the general health questionnaire comprising 28 items. For statistical analysis SPSS software, version 21 was used. \u0000Results: A total of 2052 elementary school students (1373 girls and 679 boys) participated in this study. The mean ± standard deviation (SD) ages of the girls and boys were 14.1±1.7 and 13.9±1.1 years, respectively. The mean ± SD of anxiety, social dysfunction, and depression scores were 7.42±4.92, 7.35±3.33, 6.83±2.26 in the girls and 5.65±3.89, 6.30±3.09, 4.61±1.74 in the boys, respectively. The mean ± SD total scores in boys and girls were 20.48±12.31 and 27.90±14.66, respectively. \u0000Conclusion: The mental health status of elementary school students was generally low, especially in male students.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43678534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Somaye Roshannia, Somayeh Maleki-Karamolah, Z. Akhlaghi, Parastou Kordestani-Moghadam
Attention deficit hyperactivity disorder is one of the most common childhood neurodevelopmental disorders characterized by levels of attention deficit disorder, irregularity, or hyperactivity/impulsivity. Some research has shown that only a fraction of children with attention deficit hyperactivity disorder, and not all of them, suffer from performance-related impairments; but recently it has become clear that all people with this disorder are impaired in executive functions. In other words attention deficit hyperactivity disorder is fundamentally a developmental disorder of executive functions. Poor inhibitory control, continuous attention deficit, problem-solving, and behavioral inhibition are cognitive deficits in children with attention deficit hyperactivity disorder that they are exhibit in tests related to executive functions. Evidences suggest differences in some executive functions, such as behavioral inhibition between boys and girls. Attention deficit hyperactivity disorder has its neurobiological basis and most empirical evidence indicates delayed frontal lobe development in children with this disorder. Therefore, the purpose of this study was to review cognitive disorders in children with attention deficit hyperactivity disorder with an emphasis on executive functions.
{"title":"A Review of Cognitive Disorders in Attention Deficit Hyperactivity Disorder with Emphasis on Executive Functions and Brain Structures","authors":"Somaye Roshannia, Somayeh Maleki-Karamolah, Z. Akhlaghi, Parastou Kordestani-Moghadam","doi":"10.34172/icnj.2021.14","DOIUrl":"https://doi.org/10.34172/icnj.2021.14","url":null,"abstract":"Attention deficit hyperactivity disorder is one of the most common childhood neurodevelopmental disorders characterized by levels of attention deficit disorder, irregularity, or hyperactivity/impulsivity. Some research has shown that only a fraction of children with attention deficit hyperactivity disorder, and not all of them, suffer from performance-related impairments; but recently it has become clear that all people with this disorder are impaired in executive functions. In other words attention deficit hyperactivity disorder is fundamentally a developmental disorder of executive functions. \u0000Poor inhibitory control, continuous attention deficit, problem-solving, and behavioral inhibition are cognitive deficits in children with attention deficit hyperactivity disorder that they are exhibit in tests related to executive functions. Evidences suggest differences in some executive functions, such as behavioral inhibition between boys and girls. Attention deficit hyperactivity disorder has its neurobiological basis and most empirical evidence indicates delayed frontal lobe development in children with this disorder. \u0000Therefore, the purpose of this study was to review cognitive disorders in children with attention deficit hyperactivity disorder with an emphasis on executive functions.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44623677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sayedali Ahmadi, Saeid Safari, M. Chardoli, M. Mirsalehi
Diffuse glioma is a primary brain tumor that originates from glial supportive cells and is the most common type of intra-axial brain tumor. Open tumor resection is the first step in the treatment of diffuse gliomas. The extent of resection (EOR) directly influences clinical outcomes in glioma surgery. However, resection of diffuse glioma is encountered with the problem of macroscopic and even microscopic similarity of normal brain and tumor. Furthermore, maximizing EOR requires attention because a mistake in identifying and preserving normal brain regions in complete resection can lead to catastrophic complications.
{"title":"Intraoperative Ultrasonography in Resection of Diffuse Glioma","authors":"Sayedali Ahmadi, Saeid Safari, M. Chardoli, M. Mirsalehi","doi":"10.34172/icnj.2021.11","DOIUrl":"https://doi.org/10.34172/icnj.2021.11","url":null,"abstract":"Diffuse glioma is a primary brain tumor that originates from glial supportive cells and is the most common type of intra-axial brain tumor. Open tumor resection is the first step in the treatment of diffuse gliomas. The extent of resection (EOR) directly influences clinical outcomes in glioma surgery. However, resection of diffuse glioma is encountered with the problem of macroscopic and even microscopic similarity of normal brain and tumor. Furthermore, maximizing EOR requires attention because a mistake in identifying and preserving normal brain regions in complete resection can lead to catastrophic complications.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44738934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farnoosh Sadat Etminan, K. Haji Alizadeh, Seyed Abdul Wahab Samavi
Background: Considering the importance of quality of life which is related to various physical, psychological, social, and political dimensions of the individual and the importance of the class which plays a decisive role in forming a successful and healthy society. Also, considering the importance of high-risk behaviors in today’s society and the harm that these behaviors create, five variables of quality of life, type of parent-child relationship and sensation seeking, self-efficacy, and high-risk sexual behaviors have been studied together.Methods: The research method was descriptive-correlational with structural equation modeling (SEM). The statistical population included all male and female undergraduate students of Bandar Abbas Branch of Azad University who were studying in the first semester of the 2018-2019 academic year. 260 people were selected through purposive sampling. The inclusion criteria were being an undergraduate student, conscious satisfaction with the implementation method and research process. Data were gathered by the Child-Parent Relationship Quality Questionnaire (PCRS), Zuckerman Sensation Seeking Scale, Quality of Life Questionnaire, High-Risk Sexual Behaviors Questionnaire and Emotional Self-efficacy Scale. Data were analyzed using structural equations with Amos software, version 8.80.Results: The path coefficient between high-risk sexual behaviors and quality of life was -0.84, which indicates the negative and inverse effect of high-risk sexual behaviors and quality of life. The path coefficient between the quality of the parent-child relationship and high-risk sexual behaviors was -0.86, which indicates the negative and inverse effect of the quality of the parent-child relationship and high-risk sexual behaviors.Conclusion: High-risk sexual behaviors mediate the quality of the parent-child relationship and the quality of life of students.
{"title":"The Relationship Between Emotional Self-efficacy, Sensation Seeking, and the Quality of Child-Parent Relationships With Quality of Life Mediated by High-Risk Sexual Behaviors in Students","authors":"Farnoosh Sadat Etminan, K. Haji Alizadeh, Seyed Abdul Wahab Samavi","doi":"10.34172/icnj.2021.19","DOIUrl":"https://doi.org/10.34172/icnj.2021.19","url":null,"abstract":"Background: Considering the importance of quality of life which is related to various physical, psychological, social, and political dimensions of the individual and the importance of the class which plays a decisive role in forming a successful and healthy society. Also, considering the importance of high-risk behaviors in today’s society and the harm that these behaviors create, five variables of quality of life, type of parent-child relationship and sensation seeking, self-efficacy, and high-risk sexual behaviors have been studied together.Methods: The research method was descriptive-correlational with structural equation modeling (SEM). The statistical population included all male and female undergraduate students of Bandar Abbas Branch of Azad University who were studying in the first semester of the 2018-2019 academic year. 260 people were selected through purposive sampling. The inclusion criteria were being an undergraduate student, conscious satisfaction with the implementation method and research process. Data were gathered by the Child-Parent Relationship Quality Questionnaire (PCRS), Zuckerman Sensation Seeking Scale, Quality of Life Questionnaire, High-Risk Sexual Behaviors Questionnaire and Emotional Self-efficacy Scale. Data were analyzed using structural equations with Amos software, version 8.80.Results: The path coefficient between high-risk sexual behaviors and quality of life was -0.84, which indicates the negative and inverse effect of high-risk sexual behaviors and quality of life. The path coefficient between the quality of the parent-child relationship and high-risk sexual behaviors was -0.86, which indicates the negative and inverse effect of the quality of the parent-child relationship and high-risk sexual behaviors.Conclusion: High-risk sexual behaviors mediate the quality of the parent-child relationship and the quality of life of students.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49633542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alzheimer’s disease is known as a most common dementia disorder in the world. The famous hypothesis about the cause of this disease is beta-amyloid (Aβ ) accumulation in the brain. There is a widespread neuroinflammation in the patient’s brain, leading to neuronal apoptosis and brain atrophy. Curcumin is a well-known anti-inflammation and anti-oxidant ingredient. It can easily cross the blood-brain barrier. There are controversial results about the effects of curcumin on Aβ clearance and metabolism in Alzheimer’s disease and the elderly. The aim of this meta-analysis and systematic review was to review the effect of curcumin on Aβ clearance in clinical studies. We performed a systematic review and meta-analysis on the three randomized clinical trials (RCTs) and one pilot study that assessed the effect of curcumin on Aβ plasma level in Alzheimer’s disease. For this purpose, we searched PubMed and Scopus databases up to December 2020. Our result showed there was no significant change in serum Aβ level (weighted mean difference [WMD]: 5.3, 95% CI: 0.78-9.97) following curcumin consumption in patients with Alzheimer’s disease. Further clinical trials should be done to evaluate the effects of curcumin in Aβ level in Alzheimer’s disease.
{"title":"Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis","authors":"S. Mehrabadi, Azam Alinaghpour, E. Zahedi","doi":"10.34172/icnj.2021.13","DOIUrl":"https://doi.org/10.34172/icnj.2021.13","url":null,"abstract":"Alzheimer’s disease is known as a most common dementia disorder in the world. The famous hypothesis about the cause of this disease is beta-amyloid (Aβ ) accumulation in the brain. There is a widespread neuroinflammation in the patient’s brain, leading to neuronal apoptosis and brain atrophy. Curcumin is a well-known anti-inflammation and anti-oxidant ingredient. It can easily cross the blood-brain barrier. There are controversial results about the effects of curcumin on Aβ clearance and metabolism in Alzheimer’s disease and the elderly. The aim of this meta-analysis and systematic review was to review the effect of curcumin on Aβ clearance in clinical studies. We performed a systematic review and meta-analysis on the three randomized clinical trials (RCTs) and one pilot study that assessed the effect of curcumin on Aβ plasma level in Alzheimer’s disease. For this purpose, we searched PubMed and Scopus databases up to December 2020. Our result showed there was no significant change in serum Aβ level (weighted mean difference [WMD]: 5.3, 95% CI: 0.78-9.97) following curcumin consumption in patients with Alzheimer’s disease. Further clinical trials should be done to evaluate the effects of curcumin in Aβ level in Alzheimer’s disease.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69815051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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