A. Sururi, M. Raihan, Elvira Ratna Aisa, Frisca Nadya Safitri, Irene Cornelia Constaty, Tukiran
Syzygium samarangense is a plant that is rich in flavonoid compounds. Previous researchrevealed that the dichloromethane fraction from the stem bark extract contained fourbioactive compounds, namely, pinocembrin, uvangoletin, stercurensin, and aurentiacin,which had good antioxidant activity. However, research on the potential of these fourcompounds as an anti-inflammatory has not been revealed. This study aims to continueprevious research in revealing the potential of compounds in the dichloromethane fractionof S. samarangense extract as an anti-inflammatory agent in silico COX-2 inhibitors. Thisstudy uses in silico biocomputation, including drug-likeness analysis and molecular dockinganalysis using COX-2 protein and the control drug rofecoxib. The results showed that thereare compounds that have the potential as anti-inflammatory compounds, namelypinocembrin. However, further studies, such as in vitro and in vivo, are still needed to revealits potential as an anti-inflammatory agent
{"title":"ANTI-INFLAMMATORY ACTIVITY OF STEM BARK DICHLOROMETHANE FRACTION Syzygium samarangense EXTRACT AS COX-2 INHIBITOR: A BIOINFORMATICS APPROACH","authors":"A. Sururi, M. Raihan, Elvira Ratna Aisa, Frisca Nadya Safitri, Irene Cornelia Constaty, Tukiran","doi":"10.20473/jkr.v7i2.39662","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.39662","url":null,"abstract":" Syzygium samarangense is a plant that is rich in flavonoid compounds. Previous researchrevealed that the dichloromethane fraction from the stem bark extract contained fourbioactive compounds, namely, pinocembrin, uvangoletin, stercurensin, and aurentiacin,which had good antioxidant activity. However, research on the potential of these fourcompounds as an anti-inflammatory has not been revealed. This study aims to continueprevious research in revealing the potential of compounds in the dichloromethane fractionof S. samarangense extract as an anti-inflammatory agent in silico COX-2 inhibitors. Thisstudy uses in silico biocomputation, including drug-likeness analysis and molecular dockinganalysis using COX-2 protein and the control drug rofecoxib. The results showed that thereare compounds that have the potential as anti-inflammatory compounds, namelypinocembrin. However, further studies, such as in vitro and in vivo, are still needed to revealits potential as an anti-inflammatory agent","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84111702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The research aims to see the effect of sonication on the properties and capacitance of composites made of microcellulose isolated from Oil Palm Empty Fruit Bunches and Polypyrrole (PPy). PPy is a conductive polymer limited by its inflexibility; hence PPy is blended with microcellulose which can serve as a good matrix to increase the flexibility of PPy. The procedure to isolate the microcellulose was done by delignification, bleaching, and hydrolysis. In order to see the effect of sonication, hydrolysis was undertaken in two different ways : (i) without sonication and (ii) using sonication. Besides, the polymerization time for pyrrole was also varied: 4 and 16 hours and simultaneously composited with each microcellulose from (i) and (ii). The results show an increase in cellulose crystallinity from 35.6% without sonication to 40% after sonication, while the diameter of the sonicated microcellulose fibers tends to be smaller than the counterpart. The 4-hour polymerization time shows that the composite containing the unsonicated microcellulose has a higher capacitance than the composite with the sonicated microcellulose, 14.8 nF and 8.8 nF, respectively. Meanwhile, a similar capacitance is measured for the 16-hour polymerization, 1.90 nF and 2.68 nF, using the sonicated and un-sonicated microcellulose. Overall, although the capacitances of the composites are in the nanofarad scale, it can be said that the composite can be potentially used as a capacitor.
{"title":"EFFECT OF SONICATION ON THE PROPERTIES OF COMPOSITE POLYPYRROLE/MICROCELLULOSE AND ITS POTENTIAL AS A CAPACITOR","authors":"Berlian Sitorus, Deni Pranata, Mariana Bara’allo Malino","doi":"10.20473/jkr.v7i2.39416","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.39416","url":null,"abstract":"The research aims to see the effect of sonication on the properties and capacitance of composites made of microcellulose isolated from Oil Palm Empty Fruit Bunches and Polypyrrole (PPy). PPy is a conductive polymer limited by its inflexibility; hence PPy is blended with microcellulose which can serve as a good matrix to increase the flexibility of PPy. The procedure to isolate the microcellulose was done by delignification, bleaching, and hydrolysis. In order to see the effect of sonication, hydrolysis was undertaken in two different ways : (i) without sonication and (ii) using sonication. Besides, the polymerization time for pyrrole was also varied: 4 and 16 hours and simultaneously composited with each microcellulose from (i) and (ii). The results show an increase in cellulose crystallinity from 35.6% without sonication to 40% after sonication, while the diameter of the sonicated microcellulose fibers tends to be smaller than the counterpart. The 4-hour polymerization time shows that the composite containing the unsonicated microcellulose has a higher capacitance than the composite with the sonicated microcellulose, 14.8 nF and 8.8 nF, respectively. Meanwhile, a similar capacitance is measured for the 16-hour polymerization, 1.90 nF and 2.68 nF, using the sonicated and un-sonicated microcellulose. Overall, although the capacitances of the composites are in the nanofarad scale, it can be said that the composite can be potentially used as a capacitor.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85095039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the Zingiber species that has long been used as traditional medicine by local Indonesian people is lempuyang (Zingiber ssp.). In its use as traditional medicine, it is more often used than other types of lempuyang, namely the lempuyang gajah (Zingiber zerumbet (L.) Roscoeex Sm.). Therefore, this study focused on the Zingiber zerumbet (L.) Roscoeex Sm. Most of the biological activities reported for this plant are attributed to phenolic contents and volatile principles. Hence, a detailed investigation of antioxidant activity, flavonoid, and phenolic content of Zingiber zerumbet (L.) Roscoeex Sm. rhizome was carried out. The purpose of this study was to determine the total flavonoid, phenolic, and antioxidant activity of Zingiber zerumbet (L.) Roscoeex Sm. extract in several methods of reducing free radicals DPPH, FIC, FRAP, and ABTS. The extraction method used is maceration extraction with 70% ethanol solvent and concentrated. The total phenolic content was determined by the Folin-Ciocalteu method with gallic acid as the standard, while the total flavonoid content was determined by the quercetin method. Ascorbic acid was used as a positive control of antioxidant activity. The Zingiber zerumbet (L.) Roscoeex Sm. plant used was obtained from the village of Tegal Bulu Banyuwangi. This type of research is an experimental study with the concentration of the extract used, namely 20, 40, 60, 80, and 100 mg/L. The results showed that the ethanol extract of Zingiber zerumbet (L.) Roscoeex Sm. rhizome contained total phenolic and flavonoid content of 23.58±0.25 mgGAE/g and 12.21±0.03 QUE/g extract, respectively. Antioxidant activity with IC50 value in the DPPH free radical reduction method of 11.40 ± 0.23 which is included in the very strong category, FIC of 121.46±2.93 which is included in the medium category, FRAP of 19.38±0.14 which is included in the very strong category, and ABTS of 89.32±0.15 which is included in the strong category. Phenolics and flavonoids are thought to have an important role in the antioxidant activity of Zingiber zerumbet (L.) Roscoeex Sm. rhizome.
{"title":"ANTIOXIDANT ACTIVITIES USING DPPH, FIC, FRAP, AND ABTS METHODS FROM ETHANOLIC EXTRACT OF LEMPUYANG GAJAH RHIZOME (Zingiber zerumbet (L.) Roscoeex Sm.)","authors":"J. Rohmah","doi":"10.20473/jkr.v7i2.34493","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.34493","url":null,"abstract":"One of the Zingiber species that has long been used as traditional medicine by local Indonesian people is lempuyang (Zingiber ssp.). In its use as traditional medicine, it is more often used than other types of lempuyang, namely the lempuyang gajah (Zingiber zerumbet (L.) Roscoeex Sm.). Therefore, this study focused on the Zingiber zerumbet (L.) Roscoeex Sm. Most of the biological activities reported for this plant are attributed to phenolic contents and volatile principles. Hence, a detailed investigation of antioxidant activity, flavonoid, and phenolic content of Zingiber zerumbet (L.) Roscoeex Sm. rhizome was carried out. The purpose of this study was to determine the total flavonoid, phenolic, and antioxidant activity of Zingiber zerumbet (L.) Roscoeex Sm. extract in several methods of reducing free radicals DPPH, FIC, FRAP, and ABTS. The extraction method used is maceration extraction with 70% ethanol solvent and concentrated. The total phenolic content was determined by the Folin-Ciocalteu method with gallic acid as the standard, while the total flavonoid content was determined by the quercetin method. Ascorbic acid was used as a positive control of antioxidant activity. The Zingiber zerumbet (L.) Roscoeex Sm. plant used was obtained from the village of Tegal Bulu Banyuwangi. This type of research is an experimental study with the concentration of the extract used, namely 20, 40, 60, 80, and 100 mg/L. The results showed that the ethanol extract of Zingiber zerumbet (L.) Roscoeex Sm. rhizome contained total phenolic and flavonoid content of 23.58±0.25 mgGAE/g and 12.21±0.03 QUE/g extract, respectively. Antioxidant activity with IC50 value in the DPPH free radical reduction method of 11.40 ± 0.23 which is included in the very strong category, FIC of 121.46±2.93 which is included in the medium category, FRAP of 19.38±0.14 which is included in the very strong category, and ABTS of 89.32±0.15 which is included in the strong category. Phenolics and flavonoids are thought to have an important role in the antioxidant activity of Zingiber zerumbet (L.) Roscoeex Sm. rhizome.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80206660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tannins result from plants' secondary metabolism, closely associated with plant defense mechanisms against insects. Condensed tannins can disrupt the life cycle of parasitic nematodes starting from eggs, adult worms, and larvae. Currently, the antiparasitic properties of condensed tannins are being investigated as an alternative for controlling parasites. The people use the young Pisang Ambon (Musa × parasidiaca L.) as an anthelmintic. People generally use this part of the banana peel. Based on this, a study was conducted to determine the tannin content in the peel and fruit of Pisang Ambon (Musa × parasidiaca L.). The research was conducted by extracting the fruit and peel of young Pisang Ambon by maceration method using 96% ethanol as solvent. The Harborne method and Thin Layer Chromatography tested the presence of secondary metabolites. The tannin content was determined by the visible, ultraviolet spectrophotometric method. The qualitative results showed that the peel and fruit of Pisang Ambon contained condensed tannins. Meanwhile, the quantitative results showed that the tannin content of the fruit (54.98% w/w) was higher than the peel (14.32 %w/w).
单宁来源于植物的次生代谢，与植物对昆虫的防御机制密切相关。浓缩单宁可以破坏寄生线虫从卵、成虫和幼虫开始的生命周期。目前，人们正在研究缩合单宁的抗寄生性能，以作为控制寄生虫的替代方法。人们使用年轻的Pisang Ambon (Musa x parasidiaca L.)作为驱虫剂。人们通常使用香蕉皮的这一部分。在此基础上，对枇杷果皮和果实中的单宁含量进行了测定。以96%乙醇为溶剂，采用浸渍法提取枇杷幼果和果皮。Harborne法和薄层色谱法检测了次生代谢物的存在。采用可见、紫外分光光度法测定单宁含量。定性分析结果表明，枇杷果皮和果实中含有浓缩单宁。定量结果表明，果实单宁含量(54.98% w/w)高于果皮(14.32% w/w)。
{"title":"DETERMINING THE TANNIN CONTENT IN PISANG AMBON (Musa × paradisiaca L.) WITH THE POTENTIAL AS ANTHELMINTIC","authors":"Dwi Haryatmi, I. Susilowati","doi":"10.20473/jkr.v7i2.28859","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.28859","url":null,"abstract":"Tannins result from plants' secondary metabolism, closely associated with plant defense mechanisms against insects. Condensed tannins can disrupt the life cycle of parasitic nematodes starting from eggs, adult worms, and larvae. Currently, the antiparasitic properties of condensed tannins are being investigated as an alternative for controlling parasites. The people use the young Pisang Ambon (Musa × parasidiaca L.) as an anthelmintic. People generally use this part of the banana peel. Based on this, a study was conducted to determine the tannin content in the peel and fruit of Pisang Ambon (Musa × parasidiaca L.). The research was conducted by extracting the fruit and peel of young Pisang Ambon by maceration method using 96% ethanol as solvent. The Harborne method and Thin Layer Chromatography tested the presence of secondary metabolites. The tannin content was determined by the visible, ultraviolet spectrophotometric method. The qualitative results showed that the peel and fruit of Pisang Ambon contained condensed tannins. Meanwhile, the quantitative results showed that the tannin content of the fruit (54.98% w/w) was higher than the peel (14.32 %w/w).","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82876001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A long period of drug administration in breast cancer chemotherapy can cause various side effects. These situations encourage researchers to search for and develop alternative anticancer drugs through various approaches. This study aimed to synthesize a flavonol derivative (TF4) and to study the interactions of the synthesized compound with ER-α as one of the targeted receptors in breast cancer treatment. The synthesis was carried out using the stirring method and the study of interactions of TF4 with ER-α was performed through molecular docking against ER-α crystal structures bound to an antagonist (PDB ID: 3ERT) and agonist (PDB ID: 1A52). The synthesis of TF4 produced crude product in 58 % yield and pure product in 6 % yield. The structure of TF4 was confirmed by spectroscopic analyses including UV, FT-IR, 1D, and 2D NMR. The docking results showed that the TF4 does not form any conventional hydrogen bond with ER-α. However, it can form carbon-hydrogen (C--H) bonds and van der Walls interactions with several important residues on the active site of ER-α. In addition, the binding free energy values of TF4 (-9.14 and -9.50 kcal/mol) are more negative than estradiol (E2) as one of the natural ligands for ER-α. Thus, it can be estimated that TF4 can be bounded easier on the active site of ER-α than its natural ligand. It may presume that it can act as an estrogen antagonist because of the similarity in interactions and binding poses compared to TAM, TOR, dan 4-OHT as reference drug molecules.
{"title":"Sintesis, Karakterisasi Struktur, dan Kajian Molecular Docking Senyawa Turunan 4’-Metoksi Flavonol sebagai Antagonis Reseptor Estrogen Alpha (ER-a) pada Kanker Payudara","authors":"Ihsan Ikhtiarudin, Rahma Dona, Neni Frimayanti, R. Utami, Nurul Susianti, Abdi Wira Septama","doi":"10.25077/jrk.v13i2.553","DOIUrl":"https://doi.org/10.25077/jrk.v13i2.553","url":null,"abstract":"A long period of drug administration in breast cancer chemotherapy can cause various side effects. These situations encourage researchers to search for and develop alternative anticancer drugs through various approaches. This study aimed to synthesize a flavonol derivative (TF4) and to study the interactions of the synthesized compound with ER-α as one of the targeted receptors in breast cancer treatment. The synthesis was carried out using the stirring method and the study of interactions of TF4 with ER-α was performed through molecular docking against ER-α crystal structures bound to an antagonist (PDB ID: 3ERT) and agonist (PDB ID: 1A52). The synthesis of TF4 produced crude product in 58 % yield and pure product in 6 % yield. The structure of TF4 was confirmed by spectroscopic analyses including UV, FT-IR, 1D, and 2D NMR. The docking results showed that the TF4 does not form any conventional hydrogen bond with ER-α. However, it can form carbon-hydrogen (C--H) bonds and van der Walls interactions with several important residues on the active site of ER-α. In addition, the binding free energy values of TF4 (-9.14 and -9.50 kcal/mol) are more negative than estradiol (E2) as one of the natural ligands for ER-α. Thus, it can be estimated that TF4 can be bounded easier on the active site of ER-α than its natural ligand. It may presume that it can act as an estrogen antagonist because of the similarity in interactions and binding poses compared to TAM, TOR, dan 4-OHT as reference drug molecules.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46246649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the effects of storage time and dilution of black liquor (BL) from Acacia mangium kraft pulping on the characteristics of isolated Lignin. Lignin isolation was carried out by 1 and 2 steps of isolation using HCL 1M to precipitate Lignin, diluted before isolation. Isolated Lignin was analyzed for its acid-soluble Lignin (ASL), insoluble acid lignin (AIL), functional groups by FTIR, solubility in dioxane and NaOH and thermal properties. The effect of BL storage time was also evaluated on the characteristics of the Lignin produced. The results suggest that the longer BL is stored, the higher the lignin yield. When compared to the isolation approach without dilution, the dilution process produced a higher yield and ash content up to 84% and 21%, respectively. Without dilution, the AIL isolated was lower than the dilution during BL storage. The longer the storage duration, the higher the lignin purity. Compared to two-step lignin isolation, dilution treatment in single-step isolation improves yield and purity. The thermal stability of lignin isolation without dilution (184 ⁰C and 167 ⁰C for 1 and 2 steps, respectively) was higher than that of isolated Lignin with dilution (154.8 ⁰C and 160.9 ⁰C for 1 and 2 steps, respectively), according to thermal study. Both lignin isolates with and without dilution have comparable functional groups, as shown by FTIR spectra. Due to the high yield and purity of isolated Lignin, BL dilution could be a viable alternative in lignin isolation from BL. Moreover, the properties of isolated Lignin are also influenced by BL storage.
{"title":"Pengaruh Lama Penyimpanan dan Pengenceran Lindi Hitam Terhadap Karakteristik Lignin Kraft Acacia mangium","authors":"Faizatul Falah, Rikna Naila Salsabila, Wita Pradiani, Azizatul Karimah, Muhammad Adly Rahandi Lubis, A. Prianto, Nissa Nurfajrin Solihat, Fahriya Puspita Sari, Rita Rusman, Irawan Kusuma Wijaya, Widya Fatriasari","doi":"10.25077/jrk.v13i2.506","DOIUrl":"https://doi.org/10.25077/jrk.v13i2.506","url":null,"abstract":"This study aimed to investigate the effects of storage time and dilution of black liquor (BL) from Acacia mangium kraft pulping on the characteristics of isolated Lignin. Lignin isolation was carried out by 1 and 2 steps of isolation using HCL 1M to precipitate Lignin, diluted before isolation. Isolated Lignin was analyzed for its acid-soluble Lignin (ASL), insoluble acid lignin (AIL), functional groups by FTIR, solubility in dioxane and NaOH and thermal properties. The effect of BL storage time was also evaluated on the characteristics of the Lignin produced. The results suggest that the longer BL is stored, the higher the lignin yield. When compared to the isolation approach without dilution, the dilution process produced a higher yield and ash content up to 84% and 21%, respectively. Without dilution, the AIL isolated was lower than the dilution during BL storage. The longer the storage duration, the higher the lignin purity. Compared to two-step lignin isolation, dilution treatment in single-step isolation improves yield and purity. The thermal stability of lignin isolation without dilution (184 ⁰C and 167 ⁰C for 1 and 2 steps, respectively) was higher than that of isolated Lignin with dilution (154.8 ⁰C and 160.9 ⁰C for 1 and 2 steps, respectively), according to thermal study. Both lignin isolates with and without dilution have comparable functional groups, as shown by FTIR spectra. Due to the high yield and purity of isolated Lignin, BL dilution could be a viable alternative in lignin isolation from BL. Moreover, the properties of isolated Lignin are also influenced by BL storage.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42294510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity is a major public health problem in developing countries and is a significant risk factor for metabolic disorders. Microalgae Scenedesmus dimorphus (S. dimorphus) contains bioactive compounds such as pigment function as antioxidants, and omega-3 and omega-6 PUFAs have potential as nutraceuticals. The study aimed to evaluate the lipid profile and liver function after the administration of S. dimorphus in obese mice. The research design uses mice which are divided into 6 groups; Group 1 (G1) normal control, G2 control Obesity, G3 treatment with Orlistat, G4 treatment S. dimorphus (0.25mg/g BW), G5 treatment S. dimorphus (0.5 mg/g BW) and G6 treatment S. dimorphus (0.75 mg/g BW) each group consisted of 5 mice and 21 days of observation time. The parameters observed were lipid profile and liver function of mice. Based on the results of the study, the effective dose for treating obesity is a dose of S. dimorphus 0.75 mg/g (BW) can reduce cholesterol, triglycerides, and LDL levels, respectively 67.7 mg/dl, 49.2 mg/dl, 10 , 2 mg/dl, and increased HDL, 68.32 mg/dl compared to control of obesity (G2), respectively 108.7 mg/dl, 139.1 mg/dl, 20.6 mg/dl and HDL 60, 28 mg/dl, this dose is also effective for improving the function of blood pressure by reducing AST and ALT 15.6 U/L and 18.8 U/L, respectively, compared to the obesity group (G2), which is 26.6 U/L, and 29,7 U/L. Based on the results of the study it can be concluded that S. dimorphus is useful for anti-obesity for mice (Mus musculus).
{"title":"Evaluation of Lipid Profile and Liver Function After Administration of Scenedesmus dimorphus in Obese Mice","authors":"Armaini Armaini, Siti Hajir, Y. Rilda","doi":"10.25077/jrk.v13i2.503","DOIUrl":"https://doi.org/10.25077/jrk.v13i2.503","url":null,"abstract":"Obesity is a major public health problem in developing countries and is a significant risk factor for metabolic disorders. Microalgae Scenedesmus dimorphus (S. dimorphus) contains bioactive compounds such as pigment function as antioxidants, and omega-3 and omega-6 PUFAs have potential as nutraceuticals. The study aimed to evaluate the lipid profile and liver function after the administration of S. dimorphus in obese mice. The research design uses mice which are divided into 6 groups; Group 1 (G1) normal control, G2 control Obesity, G3 treatment with Orlistat, G4 treatment S. dimorphus (0.25mg/g BW), G5 treatment S. dimorphus (0.5 mg/g BW) and G6 treatment S. dimorphus (0.75 mg/g BW) each group consisted of 5 mice and 21 days of observation time. The parameters observed were lipid profile and liver function of mice. Based on the results of the study, the effective dose for treating obesity is a dose of S. dimorphus 0.75 mg/g (BW) can reduce cholesterol, triglycerides, and LDL levels, respectively 67.7 mg/dl, 49.2 mg/dl, 10 , 2 mg/dl, and increased HDL, 68.32 mg/dl compared to control of obesity (G2), respectively 108.7 mg/dl, 139.1 mg/dl, 20.6 mg/dl and HDL 60, 28 mg/dl, this dose is also effective for improving the function of blood pressure by reducing AST and ALT 15.6 U/L and 18.8 U/L, respectively, compared to the obesity group (G2), which is 26.6 U/L, and 29,7 U/L. Based on the results of the study it can be concluded that S. dimorphus is useful for anti-obesity for mice (Mus musculus).","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43128598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurhamidah Nurhamidah, Rima Fadillah, Elvinawati Elvinawati, D. Handayani
Consuming food containing high level of purin leads to increase uric acid in the blood which, in turn, cause hyperuricemia or high uric acid level. The use of improper allopurinol for hyperuricemia medication that doesn’t follow medical doctor’s prescription can give harmful side effect. It is therefore required to use an alternative safe medication. Uncaria cordata (Lour.) Merr.) is a plant often used for medication of high levels of blood uric acid by communities in Pasar Ngalam village, Bengkulu Province. This research aims to evaluate the potency of extracted compounds from Uncaria cordata (Lour.) Merr.) in reducing uric acid of Mus musculus suffering from hyperuricemia. This research is a laboratory experiment using completed random design. As many as 25 Mus musculus were divided into 5 groups of treatment: PN = normal treatment, PA = treated with allopurinol, P1 – P3 = treated with extracted compound of Uncaria cordata (Lour.) Merr.) with a dose of 5.3 mg/30gBW (P1); 10.6 mg/30gBW (P2); and 21.2 mg/30gBW (P3). In order for Mus musculus to suffer from high uric acid level, potassium oxonate-induced hyperuricemia was injected. The result showed that extracted compounds of Uncaria cordata (Lour.) Merr.) using ethanol exhibited antihyperuricemia proven by decline of uric acid level of Mus musculus from hyperuricemia on each given dose. Decreasing uric acid level for each given dose of ethanol extract (5.3 mg/30gBW, 10.6mg/30gBW and 21.2mg/30gBW) was not significant different (0.541; with a ³0.05).
{"title":"Aktivitas Anti Hiperurisemia Ekstrak Akar Kaik-kaik (Uncaria cordata. L. Merr) pada Mencit (Mus muscullus) yang Diinduksi Kalium Oksonat","authors":"Nurhamidah Nurhamidah, Rima Fadillah, Elvinawati Elvinawati, D. Handayani","doi":"10.25077/jrk.v13i2.517","DOIUrl":"https://doi.org/10.25077/jrk.v13i2.517","url":null,"abstract":"Consuming food containing high level of purin leads to increase uric acid in the blood which, in turn, cause hyperuricemia or high uric acid level. The use of improper allopurinol for hyperuricemia medication that doesn’t follow medical doctor’s prescription can give harmful side effect. It is therefore required to use an alternative safe medication. Uncaria cordata (Lour.) Merr.) is a plant often used for medication of high levels of blood uric acid by communities in Pasar Ngalam village, Bengkulu Province. This research aims to evaluate the potency of extracted compounds from Uncaria cordata (Lour.) Merr.) in reducing uric acid of Mus musculus suffering from hyperuricemia. This research is a laboratory experiment using completed random design. As many as 25 Mus musculus were divided into 5 groups of treatment: PN = normal treatment, PA = treated with allopurinol, P1 – P3 = treated with extracted compound of Uncaria cordata (Lour.) Merr.) with a dose of 5.3 mg/30gBW (P1); 10.6 mg/30gBW (P2); and 21.2 mg/30gBW (P3). In order for Mus musculus to suffer from high uric acid level, potassium oxonate-induced hyperuricemia was injected. The result showed that extracted compounds of Uncaria cordata (Lour.) Merr.) using ethanol exhibited antihyperuricemia proven by decline of uric acid level of Mus musculus from hyperuricemia on each given dose. Decreasing uric acid level for each given dose of ethanol extract (5.3 mg/30gBW, 10.6mg/30gBW and 21.2mg/30gBW) was not significant different (0.541; with a ³0.05).","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44631602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Refilda Refilda, Riga Habib Ngestu, Emil Salim, Yefrida
The synthetic chemicals is a common substance used to extend the shelf life of postharvest fruit. But it can have health impact. The use of edible coatings from natural ingredients has begun to be developed. Modification of aloe vera gel by guava leaf extract as the edible coating to increase guava fruit shelf life has not been reported yet. Guava fruit coated by several compositions of aloe vera gel and guava leaf extract have been carried out. Observations on physichochemical in fruit on the days 0, 3, 6, 9, 12 and 15 were evaluated. The best quality found on guava fruit treated with the compotition of aloe vera gel:ethanol guava leaf extract: CMC:glycerol (90: 5:0.25: 0.5) on the day 15. It had a weight loss of 9.88%, a spoilage of 3.33%, the decrease of water content 11.61%, titratable acidity 0.5%, total antioxidant 1.08 mg AA/g FW, total phenolic 0.51 mg GAE/g FW, and increase of total dissolved solids 3.01 oBrix. This result was significantly better than the uncoated fruit. It can be concluded that guava leaf extract can be used to maintain the physicochemical properties during storage.
{"title":"Teknik Edible Coating dengan menggunakan Campuran Gel Lidah Buaya dan Ekstrak Daun Psidium guajava L. untuk Mempertahankan Sifat Fisikokimia Buah Jambu Biji","authors":"Refilda Refilda, Riga Habib Ngestu, Emil Salim, Yefrida","doi":"10.25077/jrk.v13i2.501","DOIUrl":"https://doi.org/10.25077/jrk.v13i2.501","url":null,"abstract":"The synthetic chemicals is a common substance used to extend the shelf life of postharvest fruit. But it can have health impact. The use of edible coatings from natural ingredients has begun to be developed. Modification of aloe vera gel by guava leaf extract as the edible coating to increase guava fruit shelf life has not been reported yet. Guava fruit coated by several compositions of aloe vera gel and guava leaf extract have been carried out. Observations on physichochemical in fruit on the days 0, 3, 6, 9, 12 and 15 were evaluated. The best quality found on guava fruit treated with the compotition of aloe vera gel:ethanol guava leaf extract: CMC:glycerol (90: 5:0.25: 0.5) on the day 15. It had a weight loss of 9.88%, a spoilage of 3.33%, the decrease of water content 11.61%, titratable acidity 0.5%, total antioxidant 1.08 mg AA/g FW, total phenolic 0.51 mg GAE/g FW, and increase of total dissolved solids 3.01 oBrix. This result was significantly better than the uncoated fruit. It can be concluded that guava leaf extract can be used to maintain the physicochemical properties during storage.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41877040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The thermal properties of the double perovskite SmBa0.5Sr0.5Co2O5+δ (70%) + SDC (30%) have been investigated as potential cathodes for intermediate-temperature solid oxide fuel cells (IT-SOFC). This study also includes the oxygen content and electrochemical performance of long-term tests carried out to evaluate the electrochemical stability. Cathode powder is fabricated by a simple and relatively inexpensive solid-state reaction. Oxygen content decreased gradually from room temperature to 800oC by 18.3%. Doping 30% SDC into SBSC oxide can reduce the thermal expansion coefficients (TEC) value from 19.80 x 10-6 (K-1) to 18.17 x 10-6 (K-1) or a decrease of 8.23%. The activation energy (Ea) identified by the electrochemical impedance spectroscopy (EIS), low field (LF), and high field (HF) techniques were 125.3 kJ mol-1, 60.6 kJ mol-1, and 62.5 kJ mol-1, respectively. The SBSC73|SDC|SBSC73 symmetric cell test for 96 hours at 600oC showed an increase in the average polarization resistance value of 0.30% h-1. The cathode grains are evenly distributed with a size of 2-3 µm and tend to be porous. These results exhibit that SmBa0.5Sr0.5Co2O5+δ (70%) + SDC (30%) is a promising cathode material for IT-SOFCs.
{"title":"Ekspansi Termal, Oxygen Content, dan Sifat Elektrokimia Oksida SmBa0.5Sr0.5Co2O5+δ (70%) + SDC (30%) Sebagai Katoda SOFC","authors":"Adi Subardi, Yen-Pei Fu","doi":"10.25077/jrk.v13i2.557","DOIUrl":"https://doi.org/10.25077/jrk.v13i2.557","url":null,"abstract":"The thermal properties of the double perovskite SmBa0.5Sr0.5Co2O5+δ (70%) + SDC (30%) have been investigated as potential cathodes for intermediate-temperature solid oxide fuel cells (IT-SOFC). This study also includes the oxygen content and electrochemical performance of long-term tests carried out to evaluate the electrochemical stability. Cathode powder is fabricated by a simple and relatively inexpensive solid-state reaction. Oxygen content decreased gradually from room temperature to 800oC by 18.3%. Doping 30% SDC into SBSC oxide can reduce the thermal expansion coefficients (TEC) value from 19.80 x 10-6 (K-1) to 18.17 x 10-6 (K-1) or a decrease of 8.23%. The activation energy (Ea) identified by the electrochemical impedance spectroscopy (EIS), low field (LF), and high field (HF) techniques were 125.3 kJ mol-1, 60.6 kJ mol-1, and 62.5 kJ mol-1, respectively. The SBSC73|SDC|SBSC73 symmetric cell test for 96 hours at 600oC showed an increase in the average polarization resistance value of 0.30% h-1. The cathode grains are evenly distributed with a size of 2-3 µm and tend to be porous. These results exhibit that SmBa0.5Sr0.5Co2O5+δ (70%) + SDC (30%) is a promising cathode material for IT-SOFCs.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41493461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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