A. Mukaromah, F. A. Wardoyo, Ayu Rachmawati Sulistyaningtyas, Haikal Naufal Ghazi
Mn (II) is a metal ion commonly used in steel alloys, pigment industries, welding, fertilizers, pesticides, ceramics, and electronics. According to the Regulation of the Minister of Health No. 32 of 2017, the permissible content of Manganese in dug well water is 0.5 mg/L. The purpose of this study was to determine the concentration of Mn (II) ions in water before and after passing through a Moringa Seeds Powder (MSP)-TiO2 membrane 20:1; 20:3; 20:5; 20:7; 20:9 and measure the percentage decrease in the concentration of Mn (II) ions in water after through the MSP-TiO2 membrane. The object of this research is a 55 ppm Mn (II) ion artificial sample at a flow rate of 0.56 mL/minute for 90 minutes with 90-watt radiation UV. The concentration of Mn (II) ion was measured by visible spectrophotometric method, the morphology of MSP, TiO2, and MSP-TiO2 membranes was characterized by SEM-EDX, and its diffraction spectra by X-Ray diffraction. The results obtained that the initial Mn(II) was 55.06 ± 0.031 ppm, the concentration of Mn (II) ions with the MSP-TiO2 membrane of mass MSP-TiO2 were 20:1; 20:3; 20:5; 20:7; 20:9 respectively 36.47±0.00; 44.16±1.15; 44.31±1.04; 44.94±0.94; 42.27±2.61 ppm. The percentage of decrease concentration of Mn (II) ion are 34.19±0.44%; 21.37±0.43%; 20.94±0.85%; 19.24±0.86%; and 19.66±0.86%. The highest percentage decrease in Mn (II) ion concentration was 34.15±0.44% in the variation of mass MSP-TiO2 20:1. This study concludes that the MSP-TiO2 membrane has the potential to reduce the concentration of Mn (II) ions in water.
{"title":"Decreasing of Mangan (II) in The Water Using Membrane of Moringa Seed Powder-TiO2 with Variation of Mass TiO2","authors":"A. Mukaromah, F. A. Wardoyo, Ayu Rachmawati Sulistyaningtyas, Haikal Naufal Ghazi","doi":"10.25077/jrk.v14i1.512","DOIUrl":"https://doi.org/10.25077/jrk.v14i1.512","url":null,"abstract":"Mn (II) is a metal ion commonly used in steel alloys, pigment industries, welding, fertilizers, pesticides, ceramics, and electronics. According to the Regulation of the Minister of Health No. 32 of 2017, the permissible content of Manganese in dug well water is 0.5 mg/L. The purpose of this study was to determine the concentration of Mn (II) ions in water before and after passing through a Moringa Seeds Powder (MSP)-TiO2 membrane 20:1; 20:3; 20:5; 20:7; 20:9 and measure the percentage decrease in the concentration of Mn (II) ions in water after through the MSP-TiO2 membrane. The object of this research is a 55 ppm Mn (II) ion artificial sample at a flow rate of 0.56 mL/minute for 90 minutes with 90-watt radiation UV. The concentration of Mn (II) ion was measured by visible spectrophotometric method, the morphology of MSP, TiO2, and MSP-TiO2 membranes was characterized by SEM-EDX, and its diffraction spectra by X-Ray diffraction. The results obtained that the initial Mn(II) was 55.06 ± 0.031 ppm, the concentration of Mn (II) ions with the MSP-TiO2 membrane of mass MSP-TiO2 were 20:1; 20:3; 20:5; 20:7; 20:9 respectively 36.47±0.00; 44.16±1.15; 44.31±1.04; 44.94±0.94; 42.27±2.61 ppm. The percentage of decrease concentration of Mn (II) ion are 34.19±0.44%; 21.37±0.43%; 20.94±0.85%; 19.24±0.86%; and 19.66±0.86%. The highest percentage decrease in Mn (II) ion concentration was 34.15±0.44% in the variation of mass MSP-TiO2 20:1. This study concludes that the MSP-TiO2 membrane has the potential to reduce the concentration of Mn (II) ions in water.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48164662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutmeg seed shell waste contains 21.34% cellulose, 12.93% lignin, 53.67% crude fiber, 6.16% ash, 0.11% phenol, and 0.38% carbonyl. The content of cellulose and lignin in the nutmeg shell waste is quite large, so it can be used as something of value. Cellulose can be synthesized into cellulose acetate. The use of cellulose acetate is very diverse, such as in the film industry, biodegradable plastics, paper coatings, metals, and glass, as an adhesive for topographic films as the main raw material in membrane synthesis processes. Therefore, it is necessary to characterize cellulose and cellulose acetate from nutmeg shell waste (Myristica fragrance) in South Aceh. The method used is in the form of cellulose isolation using the soxhletation process, then bleaching and hydrolysis processes are carried out, then it is synthesized into cellulose acetate. Characterization of cellulose by determining % yield, cellulose content, ash content, moisture content, FTIR, XRD. Characterization of cellulose acetate by determining the acetyl content and FTIR. The characterization results obtained ash content of 3.04%, moisture content of 15.55%, yield of 35.36% and 5.29% cellulose content. XRD characterization obtained a diffractogram peak at an angle of 2θ = 22.2111o, a crystallinity of 96% and a crystal size of 0.5292 nm. Characterization of the functional groups of cellulose in the form of stretching O-H, C-H and C-O groups which are at wave numbers 3331.04 cm-1, 2871.29 cm-1 and 1024.96 cm-1. Functional groups of cellulose acetate in the form of O-H, C=O, acetyl C-O, bent C-H and C-O groups are at wave numbers 3348.82 cm-1, 1719.61 cm-1, 1227.23 cm-1, 1369.50 cm-1 and 1028.62. The acetyl content is 39.18% and the degree of substitution is 2.65%.
{"title":"Karakterisasi Selulosa dan Selulosa Asetat dari Limbah Cangkang Biji Pala (Myristica Fragransi) Aceh Selatan","authors":"Bhayu Gita Bhernama","doi":"10.25077/jrk.v14i1.579","DOIUrl":"https://doi.org/10.25077/jrk.v14i1.579","url":null,"abstract":"Nutmeg seed shell waste contains 21.34% cellulose, 12.93% lignin, 53.67% crude fiber, 6.16% ash, 0.11% phenol, and 0.38% carbonyl. The content of cellulose and lignin in the nutmeg shell waste is quite large, so it can be used as something of value. Cellulose can be synthesized into cellulose acetate. The use of cellulose acetate is very diverse, such as in the film industry, biodegradable plastics, paper coatings, metals, and glass, as an adhesive for topographic films as the main raw material in membrane synthesis processes. Therefore, it is necessary to characterize cellulose and cellulose acetate from nutmeg shell waste (Myristica fragrance) in South Aceh. The method used is in the form of cellulose isolation using the soxhletation process, then bleaching and hydrolysis processes are carried out, then it is synthesized into cellulose acetate. Characterization of cellulose by determining % yield, cellulose content, ash content, moisture content, FTIR, XRD. Characterization of cellulose acetate by determining the acetyl content and FTIR. The characterization results obtained ash content of 3.04%, moisture content of 15.55%, yield of 35.36% and 5.29% cellulose content. XRD characterization obtained a diffractogram peak at an angle of 2θ = 22.2111o, a crystallinity of 96% and a crystal size of 0.5292 nm. Characterization of the functional groups of cellulose in the form of stretching O-H, C-H and C-O groups which are at wave numbers 3331.04 cm-1, 2871.29 cm-1 and 1024.96 cm-1. Functional groups of cellulose acetate in the form of O-H, C=O, acetyl C-O, bent C-H and C-O groups are at wave numbers 3348.82 cm-1, 1719.61 cm-1, 1227.23 cm-1, 1369.50 cm-1 and 1028.62. The acetyl content is 39.18% and the degree of substitution is 2.65%.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48325378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The attack of the Colletotrichum gloeosporioides fungus causes losses to farmers. The prolonged use of synthetic fungicides to treat this fungus harms the environment and consumers. Soursop leaves (Annona muricata L.) contain antioxidant compounds that act as antifeedants, contact poisons, and stomach poisons for plant pests and can potentially become a vegetable fungicide as a growth inhibitor for Colletotrichum gloeosporioides in postharvest horticulture. This study used a multilevel extraction method with solvents of n-hexane, ethyl acetate, and 95% ethanol. Tests for the content of secondary metabolites of soursop leaf extract in the form of alkaloids, flavonoids, saponins, and tannins were carried out qualitatively and quantitatively using a UV-Vis Shimadzu 1800 spectrophotometer. The inhibition test of the extract against the fungus Colletotrichum gloeosporioides was carried out using disc paper soaked with soursop leaf extract for a certain time. The qualitative test results of soursop leaf extract showed that it contained alkaloids, flavonoids, saponins, and tannins. The fungal inhibition zone test showed the most optimal results on soursop leaf extract with a long extraction time of 144 hours and a content of 50%, indicated by the largest diameter of the inhibition zone against the fungus Colletotrichum gloeosporioides, namely 1.7 cm.
{"title":"Potensi Daun Sirsak (Annona Muricata L.) sebagai Kandidat Fungisida Nabati Penghambat Pertumbuhan Cendawan Patogen Colletotrichum Gloeosporioides","authors":"Potensi Daun, Sirsak Annona, .. MuricataL, sebagai Kandidat, Fungisida Nabati, Penghambat Pertumbuhan, Cendawan Patogen, Colletotrichum Gloeosporioides, Syayyidah Fatimatuz, Lailatul Zahro, R. Putri, Galuh Istiqomah, Citra Cahya, Rohmana Denise Ayu, Christyfani Yustikaningrum, Sindhuwati, Christyfani Sindhuwati","doi":"10.25077/jrk.v14i1.590","DOIUrl":"https://doi.org/10.25077/jrk.v14i1.590","url":null,"abstract":"The attack of the Colletotrichum gloeosporioides fungus causes losses to farmers. The prolonged use of synthetic fungicides to treat this fungus harms the environment and consumers. Soursop leaves (Annona muricata L.) contain antioxidant compounds that act as antifeedants, contact poisons, and stomach poisons for plant pests and can potentially become a vegetable fungicide as a growth inhibitor for Colletotrichum gloeosporioides in postharvest horticulture. This study used a multilevel extraction method with solvents of n-hexane, ethyl acetate, and 95% ethanol. Tests for the content of secondary metabolites of soursop leaf extract in the form of alkaloids, flavonoids, saponins, and tannins were carried out qualitatively and quantitatively using a UV-Vis Shimadzu 1800 spectrophotometer. The inhibition test of the extract against the fungus Colletotrichum gloeosporioides was carried out using disc paper soaked with soursop leaf extract for a certain time. The qualitative test results of soursop leaf extract showed that it contained alkaloids, flavonoids, saponins, and tannins. The fungal inhibition zone test showed the most optimal results on soursop leaf extract with a long extraction time of 144 hours and a content of 50%, indicated by the largest diameter of the inhibition zone against the fungus Colletotrichum gloeosporioides, namely 1.7 cm.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42547104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Infection is a disease caused by bacteria. Some bacteria that can cause infection are Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis. Infection can be prevented by antibiotic therapy. Excessive use of antibiotics such as misuse of indications, free use in the community, inappropriate doses, and timing of application will cause new problems such as increasing bacterial resistance to antibiotics. The prevalence of drug-resistant bacteria is increasing in many parts of the world. However, this increase is accompanied by a downward trend in the development of new antibiotics. Thus, to overcome this problem new antibiotics have to be developed. This study aimed to synthesize a new antibiotic, namely to test amoxicillin/CuO and its antibacterial activity against E. coli, S. typhi, S. aureus, and B. subtilis. Antibacterial activity test using disc diffusion method. The XRD characterization results showed that the diffraction peaks of amoxicillin/CuO in the image above started from 21.13; 29.54; 30.67; 36.82; 39.5; 42.05; and 47.88. The SEM results of the Amoxicillin/CuO compound showed that the particle size of the compound was still in the form of a graph of 196-345 nm. The results of testing the antibacterial activity of amoxicillin/CuO compounds against E. coli, S. typhi, B. subtilis, and S. aureus showed that amoxicillin/CuO compounds had activity against all bacterial samples. Thus, amoxicillin/CuO compounds can be used as antibacterial therapy.
{"title":"SYNTHESIS, CHARACTERIZATION, AND ACTIVITY ASSESSMENT OF AMOXICYLIN/CuO COMPOUNDS AGAINST PATHOGENIC BACTERIA","authors":"Hadi Barru Hakam Fajar Siddiq, S. Azizah","doi":"10.20473/jkr.v7i2.36816","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.36816","url":null,"abstract":"Infection is a disease caused by bacteria. Some bacteria that can cause infection are Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis. Infection can be prevented by antibiotic therapy. Excessive use of antibiotics such as misuse of indications, free use in the community, inappropriate doses, and timing of application will cause new problems such as increasing bacterial resistance to antibiotics. The prevalence of drug-resistant bacteria is increasing in many parts of the world. However, this increase is accompanied by a downward trend in the development of new antibiotics. Thus, to overcome this problem new antibiotics have to be developed. This study aimed to synthesize a new antibiotic, namely to test amoxicillin/CuO and its antibacterial activity against E. coli, S. typhi, S. aureus, and B. subtilis. Antibacterial activity test using disc diffusion method. The XRD characterization results showed that the diffraction peaks of amoxicillin/CuO in the image above started from 21.13; 29.54; 30.67; 36.82; 39.5; 42.05; and 47.88. The SEM results of the Amoxicillin/CuO compound showed that the particle size of the compound was still in the form of a graph of 196-345 nm. The results of testing the antibacterial activity of amoxicillin/CuO compounds against E. coli, S. typhi, B. subtilis, and S. aureus showed that amoxicillin/CuO compounds had activity against all bacterial samples. Thus, amoxicillin/CuO compounds can be used as antibacterial therapy.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":"233 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72494395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gracilaria gracilis (red macroalgae) was collected from Sayang Heulang Beach, Garut, West Java. It has a number of secondary metabolites that potentially serve as a source of natural antioxidants. The objective of this study was to compare the optimal extraction method in particular time variation for producing the highest percent of yield, antioxidant activity, and toxicity of G. gracilis methanol extract. This study was conducted experimentally, including macroalgae sampling and preparation, phytochemical screening, extraction of G. gracilis by maceration and UAE methods, antioxidant activity testing based on the DPPH test (2.2 diphenyl-1-picrylhydrazyl) and toxicity testing using the BSLT (Brine Shrimp Lethality) method. The results indicated that the methanol extract of G. gracilis contains flavonoids and steroids, with yield percentages of 12.93% for maceration and 12.1% for UAE. The antioxidant activity (IC50) of maceration was 86.46 ppm, whereas the UAE was 59.01 ppm. Then, the toxicity test (LC50) for maceration was 28.35 ppm whereas the UAE was 27.76 ppm. Macerated methanol extract and UAE G. gracilis have the potential to be powerful antioxidants based on their IC50 values. Then, macerated methanol extract and UAE are included in the highly toxic category.
{"title":"ANTIOXIDANT AND TOXICITY ACTIVITIES of Gracilaria gracilis METHANOL EXTRACT BASED ON DIFFERENT EXTRACTION METHODS","authors":"Riong seulina Panjaitan, Windri Yuliana","doi":"10.20473/jkr.v7i2.38255","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.38255","url":null,"abstract":"Gracilaria gracilis (red macroalgae) was collected from Sayang Heulang Beach, Garut, West Java. It has a number of secondary metabolites that potentially serve as a source of natural antioxidants. The objective of this study was to compare the optimal extraction method in particular time variation for producing the highest percent of yield, antioxidant activity, and toxicity of G. gracilis methanol extract. This study was conducted experimentally, including macroalgae sampling and preparation, phytochemical screening, extraction of G. gracilis by maceration and UAE methods, antioxidant activity testing based on the DPPH test (2.2 diphenyl-1-picrylhydrazyl) and toxicity testing using the BSLT (Brine Shrimp Lethality) method. The results indicated that the methanol extract of G. gracilis contains flavonoids and steroids, with yield percentages of 12.93% for maceration and 12.1% for UAE. The antioxidant activity (IC50) of maceration was 86.46 ppm, whereas the UAE was 59.01 ppm. Then, the toxicity test (LC50) for maceration was 28.35 ppm whereas the UAE was 27.76 ppm. Macerated methanol extract and UAE G. gracilis have the potential to be powerful antioxidants based on their IC50 values. Then, macerated methanol extract and UAE are included in the highly toxic category.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78905382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TZeolization of coal waste was carried out as an adsorbent for Cu(II) ions. Fly ash tailings were collected from Lati Steam Power Plant (SPP) Berau and tested using SEM instruments, X-ray diffraction and AAS. Synthetic zeolites are prepared by hydrothermal reaction under alkaline and alkaline conditions. Characterization of the synthetic zeolite using SEM has formed a zeolite material with a pore size >10 µm and shows an increase in the amount of Na from 3.06% to 11.82%. XRD results show that Na-P1 zeolite is formed at the main top of 2θ16, 30, 33, 10 and 40, 80, and the relative intensities are 34, 31 and 36, respectively. In addition, elemental materials such as silica and mullite are continuously formed on the main top of 2θ26.50 and 26.10, the relative strength of silica is 100, and the relative strength of mullite is 57.9. The optimum adsorption capacity of zeolite for maximum copper ion was 80.330% at pH=4, 97.958% at 150 mg adsorbent weight, and 94.550% at 50 min contact time. The formation of these new materials significantly improved the adsorption capacity of fly ash under optimal conditions of pH = 4, sorbent weight of 150 mg, and contact time of 50 min.
{"title":"ZEOLITIZATION OF COAL WASTE AS Cu(II) ION ADSORBENT","authors":"Nura Hamid, D. Tarigan, Chairul Saleh","doi":"10.20473/jkr.v7i2.34281","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.34281","url":null,"abstract":"TZeolization of coal waste was carried out as an adsorbent for Cu(II) ions. Fly ash tailings were collected from Lati Steam Power Plant (SPP) Berau and tested using SEM instruments, X-ray diffraction and AAS. Synthetic zeolites are prepared by hydrothermal reaction under alkaline and alkaline conditions. Characterization of the synthetic zeolite using SEM has formed a zeolite material with a pore size >10 µm and shows an increase in the amount of Na from 3.06% to 11.82%. XRD results show that Na-P1 zeolite is formed at the main top of 2θ16, 30, 33, 10 and 40, 80, and the relative intensities are 34, 31 and 36, respectively. In addition, elemental materials such as silica and mullite are continuously formed on the main top of 2θ26.50 and 26.10, the relative strength of silica is 100, and the relative strength of mullite is 57.9. The optimum adsorption capacity of zeolite for maximum copper ion was 80.330% at pH=4, 97.958% at 150 mg adsorbent weight, and 94.550% at 50 min contact time. The formation of these new materials significantly improved the adsorption capacity of fly ash under optimal conditions of pH = 4, sorbent weight of 150 mg, and contact time of 50 min.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86434066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baiq Amelia Riyandari, Yupita Tri Rizki, M. Ramdani
This research aims to synthesize the polyelectrolyte complex (PEC) using chitosan and alginate as matrix film with the addition of kelor leaves extract (Moringa oleifera). The preparation of PEC films of chitosan-alginate by addition of kelor leaves extract (Moringa oleifera) had been implemented. The kelor leaves was prepared by drying process under the sun for removing water content and the dried kelor leaves was extracted using maceration technique. The final concentrations of film solution used in this study were 0.0% (Film E0), 0.50% (Film E1), 0.75% (Film E2), and 1.00% (Film E3). The PEC chitosan-alginate films with addition of kelor extract were prepared in room temperature (± 25 °C) and pH of film solution was ± 4.0. The result of film’s characterization using FTIR spectrophotometer showed that PEC films of chitosan-alginate were formed through the molecular interaction between chitosan which protonated into amine groups (–NH3+) and alginate which dissociated into carboxylate groups (–COO−). Based on FTIR spectrum, it also showed that there were some wavenumber shifts after addition of kelor leaves extract into PEC films of chitosan-alginate. It was confirmed that there were the changing of molecular interaction between PEC chitosan-alginate films due to presence of kelor extract, indicating that PEC chitosan-alginate films with kelor extract had been formed. Morphological analysis using a scanning electron microscope (SEM) displayed both porous and heterogeneous distribution on the surface after addition of kelor extract.
{"title":"SYNTHESIS OF POLYELECTROLYTE COMPLEX FILMS OF CHITOSAN-ALGINATE BY ADDITION OF KELOR LEAVES EXTRACT (Moringa oleifera) FOR FOOD PACKAGING","authors":"Baiq Amelia Riyandari, Yupita Tri Rizki, M. Ramdani","doi":"10.20473/jkr.v7i2.28954","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.28954","url":null,"abstract":"This research aims to synthesize the polyelectrolyte complex (PEC) using chitosan and alginate as matrix film with the addition of kelor leaves extract (Moringa oleifera). The preparation of PEC films of chitosan-alginate by addition of kelor leaves extract (Moringa oleifera) had been implemented. The kelor leaves was prepared by drying process under the sun for removing water content and the dried kelor leaves was extracted using maceration technique. The final concentrations of film solution used in this study were 0.0% (Film E0), 0.50% (Film E1), 0.75% (Film E2), and 1.00% (Film E3). The PEC chitosan-alginate films with addition of kelor extract were prepared in room temperature (± 25 °C) and pH of film solution was ± 4.0. The result of film’s characterization using FTIR spectrophotometer showed that PEC films of chitosan-alginate were formed through the molecular interaction between chitosan which protonated into amine groups (–NH3+) and alginate which dissociated into carboxylate groups (–COO−). Based on FTIR spectrum, it also showed that there were some wavenumber shifts after addition of kelor leaves extract into PEC films of chitosan-alginate. It was confirmed that there were the changing of molecular interaction between PEC chitosan-alginate films due to presence of kelor extract, indicating that PEC chitosan-alginate films with kelor extract had been formed. Morphological analysis using a scanning electron microscope (SEM) displayed both porous and heterogeneous distribution on the surface after addition of kelor extract.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87561690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer is a disease caused by protein mutations, which cause cells to proliferate uncontrollably. Inhibiting the action of protein kinases is one method of preventing the signal that initiates the process of uncontrolled cell proliferation. This research aimed to determine the affinity of thiourea-derived compound ligands with the protein tyrosine kinase enzyme (PDB ID: 5LMA). The binding energy between each ligand and the tyrosine kinase receptor ranged from -87,62 to -95,26 kcal/mol. The percentage of ligand interactions varies above 80%. On the active site of the amino acid residues Leu 456, Leu 495, Ala 496, Ala 497, Arg 498, and Val 500, the tyrosine kinase enzyme binds to the ligands of thiourea-derived compounds via hydrogen, pi alkyl, and alkyl bonds. Pharmacokinetic, toxicity, and Lipinski regulation of thiourea-derived compounds yielded significant results as anticancer drug candidates.
{"title":"STUDY IN SILICO OF THIOUREA-DERIVED COMPOUNDS AS TYROSINE KINASE RECEPTOR INHIBITORS","authors":"Budi Mulyati, Sri Sutjiningtyas, Herlina","doi":"10.20473/jkr.v7i2.40036","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.40036","url":null,"abstract":"Cancer is a disease caused by protein mutations, which cause cells to proliferate uncontrollably. Inhibiting the action of protein kinases is one method of preventing the signal that initiates the process of uncontrolled cell proliferation. This research aimed to determine the affinity of thiourea-derived compound ligands with the protein tyrosine kinase enzyme (PDB ID: 5LMA). The binding energy between each ligand and the tyrosine kinase receptor ranged from -87,62 to -95,26 kcal/mol. The percentage of ligand interactions varies above 80%. On the active site of the amino acid residues Leu 456, Leu 495, Ala 496, Ala 497, Arg 498, and Val 500, the tyrosine kinase enzyme binds to the ligands of thiourea-derived compounds via hydrogen, pi alkyl, and alkyl bonds. Pharmacokinetic, toxicity, and Lipinski regulation of thiourea-derived compounds yielded significant results as anticancer drug candidates.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85708176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fawait Afnani, W. Pratiwi, Makhfud Effendy, Novi Indriyawati, Vellia Yoseva
The mineral content of seawater is a natural raw material to produce rich mineral sea salt. Rich mineral sea salt is a consumption salt with a NaCl content of <50% used to live a low sodium diet for a healthy lifestyle. In general, traditional sea salt was produced with the multistage evaporation method to obtain a NaCl content of ≥ 94.7%, whereas the production of rich mineral sea salt uses a total evaporation method and then removes the salt flower at a certain concentration to get low sodium chlorine and contain other natural minerals. This study aims to analyze the chemical content of the raw material of rich mineral sea salt. The location of seawater used as raw material for rich mineral sea salt is Camplong District, Sampang Regency. Samples were obtained from sea level with a distance of ± 400 m from the coastline and carried out during high tide conditions. The chemical analysis of seawater samples consists of Na, Mg, Ca, K, Fe, Cl− dan SO42−. The analysis method is based on the Indonesian National Standard of environmental quality test. The results of the major mineral analysis showed that the largest mineral content of seawater was calcium (Ca2+) at 492.350±10.395 mg/L and Sodium (Na+) at 482,000±1.979 mg/L. In contrast, the smallest mineral content is iron mineral (Fe2+) of < 0.08 mg/L. These results will be used for preliminary data before producing naturally rich mineral sea salt.
{"title":"ANALYSIS OF CHEMICAL CONTENTS IN RAW MATERIAL OF RICH MINERALS SEA SALT","authors":"Fawait Afnani, W. Pratiwi, Makhfud Effendy, Novi Indriyawati, Vellia Yoseva","doi":"10.20473/jkr.v7i2.38742","DOIUrl":"https://doi.org/10.20473/jkr.v7i2.38742","url":null,"abstract":"The mineral content of seawater is a natural raw material to produce rich mineral sea salt. Rich mineral sea salt is a consumption salt with a NaCl content of <50% used to live a low sodium diet for a healthy lifestyle. In general, traditional sea salt was produced with the multistage evaporation method to obtain a NaCl content of ≥ 94.7%, whereas the production of rich mineral sea salt uses a total evaporation method and then removes the salt flower at a certain concentration to get low sodium chlorine and contain other natural minerals. This study aims to analyze the chemical content of the raw material of rich mineral sea salt. The location of seawater used as raw material for rich mineral sea salt is Camplong District, Sampang Regency. Samples were obtained from sea level with a distance of ± 400 m from the coastline and carried out during high tide conditions. The chemical analysis of seawater samples consists of Na, Mg, Ca, K, Fe, Cl− dan SO42−. The analysis method is based on the Indonesian National Standard of environmental quality test. The results of the major mineral analysis showed that the largest mineral content of seawater was calcium (Ca2+) at 492.350±10.395 mg/L and Sodium (Na+) at 482,000±1.979 mg/L. In contrast, the smallest mineral content is iron mineral (Fe2+) of < 0.08 mg/L. These results will be used for preliminary data before producing naturally rich mineral sea salt.","PeriodicalId":33366,"journal":{"name":"Jurnal Riset Kimia","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85379673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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