Infection Prevention in Practice最新文献_第10页

Determinants of transmission prevention behavior among Tuberculosis patients in Surabaya, Indonesia 印度尼西亚泗水肺结核患者预防传播行为的决定因素

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1016/j.infpip.2024.100404

Ni Njoman Juliasih , Luluk Fadhoh Sakinah , Reny Mareta Sari , Hudi Winarso , Salmon Charles P.T. Siahaan , Erik Jaya Gunawan

Background

Tuberculosis (TB) is associated with significant morbidity and mortality, causing significant health challenges globally. Meanwhile, Indonesia ranks second worldwide in terms of TB prevalence, with East Java being among the most affected provinces. Surabaya, in particular, a major city reported approximately 4.628 cases in 2021, underscoring the urgent need to prevent transmission through behavior of patients. Therefore, this study aimed to analyze determinants of transmission behavior among TB patients in Surabaya, Indonesia.

Methods

The methodology used in this study was a cross-sectional design and the participants were 144 TB patients at three community health centers in Surabaya, selected using simple random sampling. Variables including knowledge level, supportive behavior, and medication adherence were analyzed and data collection was carried out using a structured questionnaire. Additionally, data analysis was performed with statistical methods to determine the significance of variables.

Results

The results showed that knowledge (P-value = <0.001), supportive behavior (P-value = 0.001), and medication adherence (P-value = 0.004) had a significant effect on transmission prevention behavior among TB patients.

Conclusion

Based on our results, it was concluded that higher knowledge level, supportive behavior, and medication adherence had a significant correlation with increased social support provided by patients in preventing and controlling TB transmission. Therefore, there is a need to implement targeted programs to enhance prevention behavior.

背景肺结核（TB）与严重的发病率和死亡率相关，在全球范围内造成了重大的健康挑战。与此同时，印度尼西亚的结核病发病率在全球排名第二，东爪哇省是受影响最严重的省份之一。尤其是泗水，这座大城市在 2021 年报告了约 4628 例病例，这凸显了通过患者行为预防传播的迫切性。因此，本研究旨在分析印度尼西亚泗水肺结核患者传播行为的决定因素。方法本研究采用横断面设计，参与者为泗水三个社区医疗中心的 144 名肺结核患者，采用简单随机抽样法选出。研究分析了包括知识水平、支持行为和服药依从性在内的变量，并使用结构化问卷进行了数据收集。结果结果显示，知识水平（P 值 = <0.001）、支持行为（P 值 = 0.001）和服药依从性（P 值 = 0.004）对肺结核患者的传播预防行为有显著影响。因此，有必要实施有针对性的计划来加强预防行为。

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引用次数: 0

Rapid implementation of a clinical decision-support workflow during the national blood culture bottle shortage 在全国血液培养瓶短缺期间快速实施临床决策支持工作流程

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-11-02 DOI: 10.1016/j.infpip.2024.100417

Saira Butt , Amy B. Kressel , Brian L. Haines , Katherine Merrill , Amber M. Ryan , Kenneth C. Gavina , Bree Weaver , Michael Kays , Molly Tieman , Margaret Muciarelli , Phillip Clapham

Background

The United States Food and Drug Administration recently announced a national blood culture (BC) bottle shortage; the exact date of restoration is still being determined.

Aim

Implement a workflow to mitigate the BC bottle shortage at our hospital.

Methods

We created the following clinical decision support workflow in electronic medical record to help mitigate BC bottle use: (a) limit to two BC in 24 hours, (b) only repeat BC if 72 hours have passed from the prior sets, (c) do not repeat BC for coagulase-negative Staphylococcus bacteremia when considered a contaminant (i.e., no implanted vascular device), (d) do not repeat BC for Streptococcus bacteremia, (e) do not repeat cultures for Gram-negative rod bacteremia unless an unknown source, immunosuppression, or clinical worsening.

Findings

Post implementation, our weekly average BC bottle use decreased to 29.5%.

Conclusion

Within three weeks of the BC bottle shortage announcement, we successfully deployed evidence-based BC restrictions in the electronic medical record (EMR), reducing our BC orders by 29.5%. We encourage others to consider and potentially replicate our workflow to contribute to diagnostic stewardship.

背景美国食品和药物管理局最近宣布全国性血液培养（BC）瓶短缺；具体恢复日期仍在确定中。方法我们在电子病历中创建了以下临床决策支持工作流程，以帮助减少 BC 瓶的使用：(a) 限制在 24 小时内进行两次 BC，(b) 只有在距离上一次 BC 已过去 72 小时时才重复 BC，(c) 如果认为凝固酶阴性葡萄球菌菌血症是污染物（即：没有植入血管装置），则不重复 BC、结论在 BC 瓶短缺公告发布后的三周内，我们成功地在电子病历 (EMR) 中部署了循证 BC 限制，将 BC 订单减少了 29.5%。我们鼓励其他人考虑并有可能复制我们的工作流程，为诊断监管做出贡献。

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引用次数: 0

Knowledge, attitudes and practices on prevention and control of high-consequence infectious diseases and critical care among intensive care personnel in Rwanda: a cross-sectional survey 卢旺达重症监护人员对高危传染病防控和重症监护的认识、态度和做法：横断面调查

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1016/j.infpip.2024.100398

L. Schneider , M. Umutoni , V. Ndagijimana , M. Abdelrhman , T. Cronen , M. Nkeshimana , P. Banguti , C. Karamira , E. Seruyange , T. Piening , A. Phuti , T. Paerisch , F. Mockenhaupt , C. Mambo Muvunyi , M. Gertler , E. Rwagasore

Introduction

Intensive care personnel in countries prone to outbreaks of high-consequence infectious diseases (HCIDs), such as Ebola virus disease, stand at the forefront of caring for affected patients. This study describes the knowledge, attitudes and practices (KAP) of intensive care personnel in Rwanda on the management and infection prevention and control (IPC) of HCIDs.

Methods

A cross-sectional survey was carried out among staff working in the 4 operational intensive care units in September 2022. The self-administered questionnaire collected information on participants' background and their KAP on critical care (CC), HCIDs and IPC.

Results

Of the 107 participants, 67 (62.6%) had less than 4 years' work experience in CC. 41 (38.3%) of them had attended trainings on IPC since 2020. In univariate analyses, a higher knowledge score was associated with being a physician, years of working in CC and differed by hospital. A large proportion perceived their knowledge on CC as good or very good (58.0%) and their everyday risk of acquiring an infection as at least high (48.6%). Overall, 72.9% reported compliance with hand hygiene measures. However, around a quarter of participants reported rarely or never avoiding recapping of needles or never or rarely taking additional precautions during aerosol-generating procedures.

Conclusions

Staff had a moderate knowledge base and might benefit from continuous learning on CC and HCIDs. The perception of high risk of infection at work stands in contrast with lack of compliance with basic IPC practices which should be reinforced to avoid preventable and potentially fatal infections.

引言在埃博拉病毒病等高致病性传染病（HCID）容易爆发的国家，重症监护人员站在护理受影响病人的最前沿。本研究描述了卢旺达重症监护人员对 HCIDs 的管理和感染预防与控制 (IPC) 的知识、态度和实践 (KAP)。方法：2022 年 9 月，对在 4 个运行中的重症监护病房工作的人员进行了横断面调查。结果在 107 名参与者中，67 人（62.6%）拥有少于 4 年的重症监护工作经验。其中 41 人（38.3%）自 2020 年以来参加过 IPC 培训。在单变量分析中，较高的知识得分与医生身份、在社区卫生中心的工作年限有关，并因医院而异。很大一部分人认为他们对 CC 的了解程度为良好或非常好（58.0%），而他们日常感染的风险至少为高（48.6%）。总体而言，72.9%的参与者表示遵守了手部卫生措施。然而，约四分之一的参与者表示很少或从未避免重新盖针，或从未或很少在产生气溶胶的程序中采取额外的预防措施。他们认为工作场所感染的风险很高，但却不遵守基本的 IPC 操作规范，而这些规范应得到加强，以避免可预防的、可能致命的感染。

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引用次数: 0

Successful control of an outbreak of Panton–Valentine leucocidin positive meticillin resistant Staphylococcus aureus in a National Burns Unit through early detection by whole genome sequencing 通过全基因组测序及早发现耐甲氧西林金黄色葡萄球菌，成功控制国家烧伤科爆发潘通-瓦伦丁白细胞介素阳性耐甲氧西林金黄色葡萄球菌疫情

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI: 10.1016/j.infpip.2024.100400

R. Traynor , G.I. Brennan , T. Hoban , A.M. Dolan , B. Boyle , B. O’ Connell , O. Shelley , T.K. Teoh

We report an outbreak of PVL-producing MRSA in the Irish National Burns Unit in 2022 involving seven patients, two staff members and two positive environmental samples. This outbreak was successfully controlled using a range of measures including staff screening, environmental screening and enhanced cleaning. The use of real time whole genome sequencing (WGS) allowed for rapid identification of relatedness and for a rapid outbreak response. We share our successful approach to control this outbreak.

我们报告了 2022 年爱尔兰国家烧伤科爆发的 PVL 产 MRSA疫情，涉及 7 名患者、2 名工作人员和 2 份阳性环境样本。我们采取了一系列措施，包括员工筛查、环境筛查和加强清洁，成功控制了疫情。实时全基因组测序 (WGS) 的使用可快速识别相关性并快速应对疫情。我们分享了控制疫情的成功方法。

引用次数: 0

Evaluation of the antimicrobial effect of a far-uv radiation lamp in a real-life environment 评估远紫外辐射灯在真实环境中的抗菌效果

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-08-18 DOI: 10.1016/j.infpip.2024.100390

Szava Bansaghi , Jörn Klein

Background

Using far-Ultraviolet-C (UVC) radiation with an emission maximum of 222 nm, has the potential to kill bacteria while not being harmful to humans and can be used continuously in public areas. Elevators pose a high risk of infection transmission, as they are small, crowded spaces with poor ventilation. In such a setting continuous decontamination would be very useful. This study aimed to measure the effectiveness of a far-UVC lamp installed in a frequently used elevator by comparing the bacterial load found in that elevator with the bacterial load in a control elevator.

Methods

Microbial load was measured by different methods; ATP bioluminescence, surface samples were collected by contact slides, contact plates, and swabbing. Air samples were also collected.

Results

No significant differences were found in the microbial content between the control elevator and the UV-lamp elevator, regardless of whether the UV-lamp was always on, or was used with a motion sensor to turn off when someone entered the elevator.

Conclusions

The results suggest that the far-UVC requires a longer time to kill the bacteria, while the people traffic were continuously re-contaminating the elevators.

背景使用最大发射波长为 222 纳米的远紫外线-C（UVC）辐射有可能杀死细菌，同时对人体无害，而且可以在公共场所持续使用。电梯空间狭小、拥挤、通风不良，因此感染传播的风险很高。在这样的环境中，持续净化将非常有用。本研究旨在通过比较电梯中发现的细菌量和对照电梯中的细菌量，来衡量安装在常用电梯中的远紫外灯的效果。结果无论紫外线灯是一直开着，还是使用运动传感器在有人进入电梯时关闭，对照电梯和紫外线灯电梯中的微生物含量都没有发现明显差异。

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引用次数: 0

Susceptibility patterns of Candida species collected from intensive care units in Portugal: a prospective study in 2020–2022 从葡萄牙重症监护室采集的念珠菌菌种的易感性模式：2020-2022 年前瞻性研究

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI: 10.1016/j.infpip.2024.100403

Teresa Nascimento , João Inácio , Daniela Guerreiro , Priscila Diaz , Patrícia Patrício , Luís Proença , Cristina Toscano , Helena Barroso

Background

For Candida infections antifungal therapy is often empirical and mainly depends on locally antifungal surveillance data, which differs between geographic regions.

Aims

To monitor the epidemiology and antifungal susceptibility of Candida spp. from combined axillar-groin samples in intensive care unit (ICU) patients on admission (day1, D1), day 5 (D5) and day 8 (D8).

Methods

From 2020 to 2022, 675 patients from three ICUs were enrolled. Candida isolates were identified by MALDI-TOF MS and PCR. In vitro antifungals susceptibility tests (AFST) were performed for fluconazole, voriconazole, amphotericin B and anidulafungin, by concentration gradient Etest® strip technique.

Results

Out of 988 swabs, 355 isolates were identified as Candida species from 232 patients, being 89 isolates retrieved from patients that remained colonised at D5 and D8. AFST was conducted for all Candida isolates. The overall rate of resistance to fluconazole was 2.7%, with 3 out of 133 C. albicans, 2 out of 89 C. parapsilosis and 2 out of 24 C. glabrata isolates identified as resistant. Voriconazole susceptibility was observed in 99.2% of the isolates, with only one C. albicans isolate identified as resistant to this triazole. All isolates were susceptible to amphotericin B and 98.5% to anidulafungin. Three Candida spp. exhibited resistance to anidulafungin, C. albicans, C. tropicalis, and C. parapsilosis.

Conclusions

This study highlights the importance of C. albicans as a frequent coloniser and showed that antifungal resistance remains uncommon among Candida isolates from ICUs in Portugal. The results may contribute to better management within institutions to guide therapeutic decision making.

Aims To monitor the epidemiology and antifungal susceptibility of Candida spp.从重症监护病房（ICU）患者入院（第1天，D1）、第5天（D5）和第8天（D8）的腋窝-胃液联合样本中监测念珠菌属的流行病学和抗真菌敏感性。通过 MALDI-TOF MS 和 PCR 鉴定念珠菌分离物。结果在 988 份拭子中，232 名患者的 355 份分离物被鉴定为念珠菌，其中 89 份分离物来自在第 5 天和第 8 天仍有定植的患者。对所有念珠菌分离物进行了 AFST 检测。对氟康唑的总体耐药率为 2.7%，133 个白色念珠菌分离株中有 3 个、89 个副丝状念珠菌分离株中有 2 个、24 个格氏念珠菌分离株中有 2 个被鉴定为耐药。99.2%的分离株对伏立康唑有敏感性，只有一个白僵菌分离株对该三唑类药物有抗药性。所有分离株都对两性霉素 B 敏感，98.5%对阿尼芬净敏感。该研究强调了白念珠菌作为一种常见定植菌的重要性，并表明抗真菌耐药性在葡萄牙重症监护病房分离出的念珠菌中仍不常见。研究结果可能有助于改善医疗机构的管理，为治疗决策提供指导。

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引用次数: 0

Status of infection prevention and control in Cameroon healthcare facilities: lessons learned from the WHO COVID-19 scorecard tool under the hierarchy of control model 喀麦隆医疗机构的感染预防和控制现状：从世卫组织 COVID-19 计分卡工具中汲取的分级控制模式的经验教训

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.infpip.2024.100407

Boris Arnaud Kouomogne Nteungue , Erick Tandi , Chanceline Bilounga Ndongo , Tania Bissouma-Ledjou , Alphonse Acho , Jeffrey Campbell , Dieudonnée Reine Ndougou , Reverien Habimana , Ambomo Sylvie Myriam , Bertolt Brecht Kouam Nteungue , Oyono Yannick , Louis Joss Bitang , Georges Alain Etoundi Mballa , Yap Boum

Background

Infection prevention and control (IPC) helps prevent disease transmission in healthcare facilities. There is a dearth of information on the implementation of IPC during the COVID-19 outbreak in Cameroon using the recommended WHO COVID-19 IPC scorecard tool. The present study assessed healthcare facilities' compliance to IPC by continuous assessments, with an evaluation of the tool using the hierarchy of control theory.

Methods

This cross-sectional study was conducted in the 10 administrative regions of Cameroon by evaluating healthcare facilities prioritized by the Ministry of Public Health as high-risk facilities between March 2020 and November 2023. Comparisons were made regarding the facilities' ownership, level and status.

Results

2,188 assessments from 1,358 healthcare facilities were collected. The median IPC scores at each evaluation were between the intermediate and advanced level, with a bias linked with decreasing selection of facilities. However, only 172 (13%) healthcare facilities achieved advanced IPC score (≥75%). Higher IPC scores were found in hospitals (p<0.001) and in private facilities (p=0.02). Predictors of good IPC compliance were hospital (OR=3.7, CI: 1.4–9.8) and private facility (OR=2.3, CI: 1.6–3.3). The tool met the five domains of the hierarchy of control model.

Conclusion

Repeated IPC assessments using recommended tools contribute to a better compliance of IPC by healthcare facilities in resources constrained settings.

背景感染预防与控制（IPC）有助于防止疾病在医疗机构中传播。关于喀麦隆在 COVID-19 爆发期间使用世界卫生组织推荐的 COVID-19 IPC 计分卡工具实施 IPC 的情况，目前还缺乏相关信息。这项横断面研究在喀麦隆的 10 个行政区进行，对公共卫生部在 2020 年 3 月至 2023 年 11 月期间优先考虑的高风险医疗机构进行了评估。结果收集了来自 1,358 家医疗机构的 2,188 份评估报告。每次评估的 IPC 得分中位数介于中级和高级之间，其中的偏差与设施选择的减少有关。然而，只有 172 家（13%）医疗机构达到了 IPC 高级水平（≥75%）。医院（p<0.001）和私营机构（p=0.02）的 IPC 得分更高。医院（OR=3.7，CI：1.4-9.8）和私营机构（OR=2.3，CI：1.6-3.3）是IPC符合性良好的预测因素。结论在资源有限的环境中，使用推荐工具重复进行 IPC 评估有助于医疗机构更好地遵守 IPC。

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引用次数: 0

Asymptomatic bacteriuria and urinary tract infection in geriatric inpatients after indwelling urinary catheter removal: a descriptive two-centre study 老年住院病人拔除留置导尿管后的无症状菌尿和尿路感染：一项描述性双中心研究

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.infpip.2024.100411

Aysel Kulbay , Eva Joelsson-Alm , Karin Amilon , Ann Tammelin

Background

Patients with indwelling urinary catheters (IUC) are common in geriatric care. Catheterization increases the risk of asymptomatic bacteriuria (ASB) and urinary tract infection (UTI). The prevalence of ASB after IUC-removal is only sparsely studied. This study aimed to compare the occurrence of ASB and UTI in geriatric patients with and without a history of catheterization and to explore factors associated with ASB.

Methods

Patients were included at two geriatric rehabilitation wards in Stockholm, Sweden. Data were collected about history of catheterization, antibiotic treatment, and diabetes mellitus. Urine samples were analysed. Occurrence of UTI during inpatient care was identified by patient records.

Results

In total 196 asymptomatic patients were included in the analysis. Asymptomatic bacteriuria was significantly more common in patients with a history of catheterization (38/104, 36.5%) compared to those without IUC during the past four weeks (19/92, 20.6%, P=0.018). Enterococci were more commonly found in patients with a history of catheterization. Of 124 patients possible to follow up, five UTI-cases were found during hospital stay. All cases had had ASB and 4/5 had had an IUC on admission.

Catheterization was significantly associated with ASB after adjustment for confounders (OR 2.79, CI 1.31–5.91, P=0.008).

Conclusions

Catheterization is associated with ASB, this persists after IUC-removal. The results indicate that colonisation by Enterococcus species linked to catheterization may persist for at least four weeks after IUC-removal.

Trial registration

The study is registered at clinicaltrials.gov with the identification number NCT05039203 (09/09/2021).

背景在老年护理中，留置导尿管（IUC）的患者很常见。导尿会增加无症状菌尿（ASB）和尿路感染（UTI）的风险。关于 IUC 拔除后 ASB 的发生率的研究很少。本研究旨在比较有导尿史和无导尿史的老年患者ASB和UTI的发生率，并探讨与ASB相关的因素。收集了有关导尿史、抗生素治疗和糖尿病的数据。对尿液样本进行了分析。住院期间发生的尿路感染通过患者记录进行确认。与过去四周内未使用 IUC 的患者（19/92，20.6%，P=0.018）相比，有导尿史的患者（38/104，36.5%）更容易出现无症状菌尿（19/92，20.6%，P=0.018）。有导管插入史的患者更常发现肠球菌。在 124 名可能接受随访的患者中，住院期间发现了 5 例尿路感染病例。在对混杂因素进行调整后，导管插入与 ASB 有显著相关性（OR 2.79，CI 1.31-5.91，P=0.008）。试验注册该研究已在 clinicaltrials.gov 注册，识别号为 NCT05039203 (09/09/2021).

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引用次数: 0

An assessment of infection prevention and control implementation in Malawian hospitals using the WHO Infection Prevention and Control Assessment Framework (IPCAF) tool 利用世界卫生组织感染预防与控制评估框架（IPCAF）工具评估马拉维医院的感染预防与控制实施情况

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-08-22 DOI: 10.1016/j.infpip.2024.100388

Dorica Ng'ambi , Thomasena O'Byrne , Emmie Jingini , Hope Chadwala , Owen Musopole , Wala Kamchedzera , Tara Tancred , Nicholas Feasey

Background

Infection prevention and control (IPC) is important for the reduction of healthcare-associated infections (HAI). The World Health Organization (WHO) developed the IPC Assessment Framework (IPCAF) tool to assess the level of IPC implementation and to identify areas for improvement in healthcare facilities.

Methods

A cross -sectional survey was conducted using the WHO IPCAF tool from May to June 2023. The aim was to provide a baseline assessment of the IPC programme and activities within health care facilities in Malawi. Forty healthcare facilities were invited to participate. IPC teams were requested to complete the IPCAF and return the scores. The IPCAF tool scores were assessed as recommended in the WHO IPCAF tool.

Results

The response rate was 82.5%. The median IPCAF score was 445 out of 800 corresponding to an intermediate IPC implementation level. The results revealed that 66.7% facilities were at intermediate level, 26.4% at basic level, and 6.9% at advanced level. Most facilities (76%) had an IPC program in place with clear objectives and an IPC focal person. Few had a dedicated budget for IPC. The IPCAF domain “monitoring/audit of IPC practices and feedback” had the lowest median score of 15/100, and in 90% of facilities, no monitoring, audit, and feedback was done. HAI surveillance median score was 40/100, workload, staffing and bed occupancy median score was 45/100.

Conclusions

Whilst there has been some degree of implementation of WHO IPC guidelines in Malawi's healthcare system, there is significant room for improvement. The IPCAF tool revealed that monitoring/audit and feedback, HAI surveillance and workload, staffing and bed occupancy need to be strengthened. The IPCAF scoring system may need reconsidering given the centrality of these domains to IPC.

背景感染预防与控制（IPC）对于减少医疗相关感染（HAI）非常重要。世界卫生组织（WHO）开发了IPC评估框架（IPCAF）工具，用于评估医疗机构实施IPC的水平，并确定需要改进的领域。目的是对马拉维医疗机构的 IPC 计划和活动进行基线评估。40 家医疗机构应邀参加了调查。要求 IPC 小组完成 IPCAF 并交回分数。按照世界卫生组织 IPCAF 工具的建议，对 IPCAF 工具得分进行了评估。IPCAF 分数的中位数为 445 分（满分 800 分），处于 IPC 实施的中等水平。结果显示，66.7%的机构处于中级水平，26.4%处于基础水平，6.9%处于高级水平。大多数医疗机构（76%）都制定了 IPC 计划，并有明确的目标和 IPC 联络人。很少有机构为 IPC 划拨了专项预算。IPCAF领域 "IPC实践的监测/审计和反馈 "的中位数得分最低，仅为15/100，90%的机构没有进行监测、审计和反馈。HAI 监测的中位数得分为 40/100，工作量、人员配备和床位占用率的中位数得分为 45/100。IPCAF 工具显示，监测/审计和反馈、HAI 监测和工作量、人员配备和床位占用率需要加强。鉴于这些领域对 IPC 的核心作用，IPCAF 评分系统可能需要重新考虑。

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引用次数: 0

Low prevalence of borderline oxacillin resistant Staphylococcus aureus (BORSA) in a tertiary care hospital in South Carolina 南卡罗来纳州一家三级护理医院中耐受奥沙西林的金黄色葡萄球菌（BORSA）的低流行率

IF 1.8 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice

Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.infpip.2024.100414

Connor Horne , Gabrielle DiMattia , Nicholas Perkins , Prerana Roth

Prompt treatment for Staphylococcus aureus bloodstream infections is often dependent on known diagnostic testing modalities to differentiate between methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). Borderline-oxacillin resistant S. aureus (BORSA), a rare, non-mecA mediated phenotype, has unclear resistance mechanisms but potentially significant consequences as it is frequently misidentified as MSSA but behaves more like MRSA. A retrospective analysis was performed of MSSA bloodstream infections to determine the prevalence of BORSA. Our institution found BORSA prevalence of 0.1%, consistent with literature. Though prevalence is low, due to unclear mechanisms and unreliable detection methods, BORSA may pose a therapeutic and epidemiological threat.

金黄色葡萄球菌血流感染的及时治疗通常取决于已知的诊断检测方法，以区分甲氧西林敏感金黄色葡萄球菌（MSSA）和耐甲氧西林金黄色葡萄球菌（MRSA）。耐边界奥沙西林金黄色葡萄球菌（BORSA）是一种罕见的、非mecA介导的表型，其耐药机制尚不清楚，但可能会产生重大影响，因为它经常被误认为是MSSA，但表现得更像MRSA。我们对 MSSA 血流感染进行了回顾性分析，以确定 BORSA 的流行率。我院发现 BORSA 感染率为 0.1%，与文献报道一致。虽然流行率较低，但由于机制不明确和检测方法不可靠，BORSA 可能会对治疗和流行病学构成威胁。

引用次数: 0