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The Effectiveness of Blue-Light-Emitting Glasses in Security Guards Exposed to Night Shift Work on Work-Related and General Fatigue: A Randomised Controlled Cross-Over Study. 蓝色发光眼镜对夜班保安工作疲劳的有效性:一项随机对照交叉研究。
IF 3.1 Q2 Neuroscience Pub Date : 2022-11-24 DOI: 10.3390/clockssleep4040051
Pieter H Helmhout, Stella Timmerman, Alwin van Drongelen, Eric W P Bakker

This study aimed to evaluate the effectiveness of glasses that emit blue light in reducing the need for recovery, general fatigue, and stress levels in security guards who work night shifts. Light manipulation is seen as a promising strategy to mitigate complaints related to shift work, such as sleepiness and impaired cognitive performance. In a randomized controlled cross-over study design, 86 Dutch security guards used light-emitting glasses (exposure duration: 30 min) during night shifts in a five week period versus a five week control period without glasses. Measurements (Need for Recovery Scale; Checklist Individual Strength; stress level assessed by a fitness tracker) were performed at baseline, at five weeks, and again at 11 weeks. The chronotype was measured at baseline as a potential covariate. A mixed model for repeated measure analyses showed no significant reduction in the need for recovery, nor a reduction in general fatigue scores, during the intervention period. Paired Samples T-Test analyses showed no significant changes in stress levels for the intervention period. Conclusively, blue light exposure using light-emitting glasses for security guards during night shifts showed no directly measurable effect on the reduced need for recovery, overall fatigue, and stress levels.

这项研究旨在评估蓝光眼镜在减少夜班保安的恢复需要、一般疲劳和压力水平方面的有效性。光操纵被认为是一种很有前途的策略,可以减轻与轮班工作有关的抱怨,比如嗜睡和认知能力受损。在一项随机对照交叉研究设计中,86名荷兰保安在五周的夜班期间使用发光眼镜(暴露时间:30分钟),而在五周的对照组中不戴眼镜。测量(需要恢复量表;个人力量;压力水平(由健身追踪器评估)分别在基线、第5周和第11周进行。在基线时测量时型作为潜在的协变量。重复测量分析的混合模型显示,在干预期间,恢复需求没有显著减少,总体疲劳评分也没有降低。配对样本t检验分析显示,在干预期间,压力水平没有显著变化。最后,保安员在夜班期间使用发光眼镜暴露在蓝光下,对减少恢复需求、整体疲劳和压力水平没有直接可测量的影响。
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引用次数: 1
Differences in Sleep Offset Timing between Weekdays and Weekends in 79,161 Adult Participants in the UK Biobank. 英国生物银行79161名成年参与者工作日和周末睡眠偏移时间的差异
IF 3.1 Q2 Neuroscience Pub Date : 2022-11-22 DOI: 10.3390/clockssleep4040050
Rachael M Kelly, John H McDermott, Andrew N Coogan

Variability in the timing of daily sleep is increasingly recognized as an important factor in sleep and general physical health. One potential driver of such daily variations in sleep timing is different work and social obligations during the "working week" and weekends. To investigate the nature of weekday/weekend differences in the timing of sleep offset, we examined actigraphy records of 79,161 adult participants in the UK Biobank who wore an actiwatch for 1 week. The time of sleep offset was found to be on average 36 min later on weekends than on weekdays, and when this difference was expressed as an absolute value (i.e., irrespective of sleep offset being either later or earlier on weekends), it was 63 min. Younger age, more socioeconomic disadvantage, currently being in employment, being a smoker, being male, being of non-white ethnicity and later chronotype were associated with greater differences in sleep offset between weekdays and weekend days. Greater differences in sleep offset timing were associated with age-independent small differences in cardiometabolic health indicators of BMI and diastolic blood pressure, but not HbA1c or systolic blood pressure. In a subset of participants with Type 2 Diabetes Mellitus, weekday/weekend sleep offset differences were associated weakly with BMI, systolic blood pressure and physical activity. Overall, this study demonstrates potentially substantive differences in sleep offset timings between weekdays and weekends in a large sample of UK adults, and that such differences may have public health implications.

每天睡眠时间的变化越来越被认为是影响睡眠和一般身体健康的一个重要因素。每天睡眠时间变化的一个潜在驱动因素是“工作日”和周末不同的工作和社会责任。为了调查工作日/周末睡眠抵消时间差异的本质,我们检查了英国生物银行79161名成年参与者的活动记录,他们戴了一周的活动手表。研究发现,周末的睡眠偏移时间平均比工作日晚36分钟,当这种差异以绝对值表示时(即,无论周末的睡眠偏移时间是晚还是早),它是63分钟。年龄更小、社会经济劣势更大、目前有工作、吸烟、男性、非白人种族和较晚的睡眠类型与工作日和周末之间的睡眠偏移差异有关。睡眠补偿时间的较大差异与年龄无关的心脏代谢健康指标BMI和舒张压的微小差异有关,但与HbA1c或收缩压无关。在一部分2型糖尿病患者中,工作日/周末睡眠抵消差异与BMI、收缩压和体力活动的相关性较弱。总的来说,这项研究表明,在英国成年人的大量样本中,工作日和周末的睡眠抵消时间存在潜在的实质性差异,这种差异可能会对公共健康产生影响。
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引用次数: 2
Impact of Solid State Roadway Lighting on Melatonin in Humans. 固态道路照明对人体褪黑激素的影响。
IF 3.1 Q2 Neuroscience Pub Date : 2022-11-18 DOI: 10.3390/clockssleep4040049
Ronald B Gibbons, Rajaram Bhagavathula, Benjamin Warfield, George C Brainard, John P Hanifin

Introduction: In 2009, the World Health Organization identified vehicle crashes, both injury-related and fatal, as a public health hazard. Roadway lighting has long been used to reduce crashes and improve the safety of all road users. Ocular light exposure at night can suppress melatonin levels in humans. At sufficient light levels, all visible light wavelengths can elicit this response, but melatonin suppression is maximally sensitive to visible short wavelength light. With the conversion of roadway lighting to solid state sources that have a greater short wavelength spectrum than traditional sources, there is a potential negative health impact through suppressed melatonin levels to roadway users and those living close to the roadway. This paper presents data on the impact of outdoor roadway lighting on salivary melatonin in three cohorts of participants: drivers, pedestrians, and those experiencing light trespass in their homes.

Methods: In an outdoor naturalistic roadway environment, healthy participants (N = 29) each being assigned to a cohort of either pedestrian, driver, or light trespass experiment, were exposed to five different solid state light sources with differing spectral emissions and one no lighting condition. Salivary melatonin measurements were made under an average roadway luminance of 1.0 cd/m2 (IES RP-18 Roadway Lighting Requirements for expressway roads) with a corneal melanopic Equivalent Daylight Illuminances (EDI) ranging from 0.22 to 0.86 lux.

Results: The results indicate that compared to the no roadway lighting condition, the roadway light source spectral content did not significantly impact salivary melatonin levels in the participants in any of the cohorts.

Conclusions: These data show that recommended levels of street lighting for expressway roads do not elicit an acute suppression of salivary melatonin and suggest that the health benefit of roadway lighting for traffic safety is not compromised by an acute effect on salivary melatonin.

导言:2009年,世界卫生组织将与伤害有关和致命的车辆碰撞确定为一种公共卫生危害。长期以来,道路照明一直被用于减少交通事故和提高所有道路使用者的安全。夜间的眼部光照会抑制人体内的褪黑激素水平。在足够的光照水平下,所有可见光波长都能引起这种反应,但褪黑激素抑制对可见光短波长的光最敏感。随着道路照明转换为比传统光源具有更大短波长光谱的固态光源,通过抑制褪黑素水平对道路使用者和生活在道路附近的人产生潜在的负面健康影响。本文介绍了户外道路照明对三组参与者唾液褪黑素影响的数据:司机、行人和那些在家中经历光侵入的人。方法:在室外自然的道路环境中,健康参与者(N = 29)分别被分配到行人、司机或光侵入实验中,暴露于五种不同光谱发射的固体光源和一种无照明条件下。唾液褪黑素测量在平均道路亮度为1.0 cd/m2 (IES RP-18高速公路道路照明要求)下进行,角膜黑视等效日光照度(EDI)范围为0.22至0.86勒克斯。结果:结果表明,与没有道路照明条件相比,道路光源光谱含量对任何队列参与者的唾液褪黑激素水平都没有显著影响。结论:这些数据表明,高速公路的推荐街道照明水平不会引起唾液褪黑素的急性抑制,并且表明道路照明对交通安全的健康益处不会受到唾液褪黑素的急性影响。
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引用次数: 1
Recovery Sleep Immediately after Prolonged Sleep Deprivation Stimulates the Transcription of Integrated Stress Response-Related Genes in the Liver of Male Rats. 长时间睡眠剥夺后立即恢复睡眠刺激雄性大鼠肝脏综合应激反应相关基因的转录。
IF 3.1 Q2 Neuroscience Pub Date : 2022-11-09 DOI: 10.3390/clockssleep4040048
Keisuke Fukuoka, Yusuke Murata, Tomomi Otomaru, Masayoshi Mori, Kenji Ohe, Kazunori Mine, Munechika Enjoji

Sleep loss induces performance impairment and fatigue. The reactivation of human herpesvirus-6, which is related to the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), is one candidate for use as an objective biomarker of fatigue. Phosphorylated eIF2α is a key regulator in integrated stress response (ISR), an intracellular stress response system. However, the relation between sleep/sleep loss and ISR is unclear. The purpose of the current study was to evaluate the effect of prolonged sleep deprivation and recovery sleep on ISR-related gene expression in rat liver. Eight-week-old male Sprague-Dawley rats were subjected to a 96-hour sleep deprivation using a flowerpot technique. The rats were sacrificed, and the liver was collected immediately or 6 or 72 h after the end of the sleep deprivation. RT-qPCR was used to analyze the expression levels of ISR-related gene transcripts in the rat liver. The transcript levels of the Atf3, Ddit3, Hmox-1, and Ppp15a1r genes were markedly increased early in the recovery sleep period after the termination of sleep deprivation. These results indicate that both activation and inactivation of ISRs in the rat liver occur simultaneously in the early phase of recovery sleep.

睡眠不足会导致行为障碍和疲劳。人疱疹病毒-6的再激活与真核翻译起始因子2α (eIF2α)的磷酸化有关,是用作疲劳客观生物标志物的一个候选物。磷酸化的eIF2α是细胞内应激反应系统综合应激反应(integrated stress response, ISR)的关键调控因子。然而,睡眠/睡眠不足与ISR之间的关系尚不清楚。本研究旨在探讨长时间睡眠剥夺和恢复性睡眠对大鼠肝脏isr相关基因表达的影响。八周大的雄性Sprague-Dawley大鼠使用花盆技术进行了96小时的睡眠剥夺。处死大鼠,在剥夺睡眠结束后立即或6、72 h取肝。RT-qPCR分析大鼠肝脏中isr相关基因转录本的表达水平。Atf3、Ddit3、Hmox-1和Ppp15a1r基因转录水平在睡眠剥夺结束后的恢复期早期显著升高。这些结果表明,大鼠肝脏isr的激活和失活同时发生在恢复性睡眠的早期阶段。
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引用次数: 0
Impact of Evening Light Exposures with Different Solid Angles on Circadian Melatonin Rhythms, Alertness, and Visual Comfort in an Automotive Setting. 汽车环境下不同立体角夜间光照对褪黑素昼夜节律、警觉性和视觉舒适度的影响
IF 3.1 Q2 Neuroscience Pub Date : 2022-10-26 DOI: 10.3390/clockssleep4040047
Michael Weng, Isabel Schöllhorn, Maryia Kazhura, Brian B Cardini, Oliver Stefani

Future automotive interior lighting might have the potential to go beyond decorative purposes by influencing alertness, circadian physiology, and sleep. As the available space in the interior of an automobile for lighting applications is limited, understanding the impact of various luminous surface sizes on non-image-forming effects is fundamental in this field. In a laboratory study using a within-subject design, 18 participants were exposed to two bright light conditions with different solid angles and one dim light condition in a balanced, randomized order during the course of the evening. Our results demonstrate that both light conditions significantly increased subjective alertness and reduced salivary melatonin concentration but not cognitive performance compared to dim light. The solid angle of light exposure at constant corneal illuminance only affected visual comfort. While subjective alertness can be increased and melatonin can be attenuated with rather small luminaires, larger solid angles should be considered if visual comfort is a priority.

未来的汽车内部照明可能会通过影响警觉性、昼夜生理和睡眠来超越装饰目的。由于汽车内部用于照明的可用空间有限,因此了解不同发光表面尺寸对非图像形成效果的影响是该领域的基础。在一项采用受试者内部设计的实验室研究中,18名参与者在晚上以平衡、随机的顺序暴露在两种不同立体角的强光条件下和一种昏暗的光线条件下。我们的研究结果表明,与昏暗的光线相比,两种光照条件都显著提高了主观警觉性,降低了唾液褪黑素浓度,但没有提高认知能力。在恒定的角膜照度下,光照射的立体角只影响视觉舒适。虽然较小的灯具可以增加主观警觉性,褪黑素可以减弱,但如果视觉舒适是优先考虑的,则应考虑较大的立体角。
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引用次数: 1
Associations among Alcohol Drinking, Smoking, and Nonrestorative Sleep: A Population-Based Study in Japan. 饮酒、吸烟和非恢复性睡眠之间的关系:日本一项基于人群的研究
IF 3.1 Q2 Neuroscience Pub Date : 2022-10-24 DOI: 10.3390/clockssleep4040046
Yuichiro Otsuka, Ohki Takeshima, Osamu Itani, Yuuki Matsumoto, Yoshitaka Kaneita

Nonrestorative sleep (NRS) is a common sleep disorder. It is associated with several unhealthy lifestyle factors, such as skipping breakfast and lack of exercise. However, the associations between alcohol drinking, smoking, and NRS are unclear. This study examined the prevalence of NRS within the Japanese general population and the relationships among alcohol drinking, smoking, and NRS. We analyzed an anonymized dataset from a 2013 nationwide population survey (35,717 men and 39,911 women). NRS was assessed through a single-item question, and socio-demographic and lifestyle factors were assessed through self-reports. Multivariable logistic regression analyses were used to examine the associations between alcohol drinking, smoking, and NRS. The total prevalence of NRS was 22.2% (95% CI 21.8-22.7) in men and 23.4% (95% CI 23.0-23.8) in women. Further, we found that sleep duration and prevalence of NRS shared an inverse J-shaped relationship. Heavy alcohol drinking was significantly associated with NRS in both sexes. Short sleep duration and certain socioeconomic factors modified the effect of smoking on NRS in men. These results could be useful in the development of more effective sleep health policies to establish better sleep hygiene.

非恢复性睡眠(NRS)是一种常见的睡眠障碍。它与几种不健康的生活方式因素有关,比如不吃早餐和缺乏锻炼。然而,饮酒、吸烟和NRS之间的关系尚不清楚。本研究调查了日本普通人群中NRS的患病率以及饮酒、吸烟与NRS之间的关系。我们分析了2013年全国人口调查的匿名数据集(35,717名男性和39,911名女性)。NRS通过单项问题进行评估,社会人口和生活方式因素通过自我报告进行评估。多变量logistic回归分析用于检验饮酒、吸烟和NRS之间的关系。NRS的总患病率男性为22.2% (95% CI 21.8-22.7),女性为23.4% (95% CI 23.0-23.8)。此外,我们发现睡眠时间和NRS患病率呈反j型关系。在两性中,大量饮酒与NRS显著相关。短睡眠时间和某些社会经济因素改变了吸烟对男性NRS的影响。这些结果可能有助于制定更有效的睡眠健康政策,以建立更好的睡眠卫生。
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引用次数: 2
Brighter Time: A Smartphone App Recording Cognitive Task Performance and Illuminance in Everyday Life. 更亮的时间:一款记录日常生活中认知任务表现和照明的智能手机应用程序。
IF 3.1 Q2 Neuroscience Pub Date : 2022-10-21 DOI: 10.3390/clockssleep4040045
Marina Gardesevic, Altug Didikoglu, Samuel J D Lawrence, Céline Vetter, Timothy M Brown, Annette E Allen, Robert J Lucas

Light is an influential regulator of behavioural and physiological state in mammals. Features of cognitive performance such as memory, vigilance and alertness can be altered by bright light exposure under laboratory and field conditions. However, the importance of light as a regulator of performance in everyday life is hard to assess and has so far remained largely unclear. We set out to address this uncertainty by developing a tool to capture measures of cognitive performance and light exposure, at scale, and during everyday life. To this end, we generated an app (Brighter Time) which incorporated a psychomotor vigilance (PVT), an N-back and a visual search task with questionnaire-based assessments of demographic characteristics, general health, chronotype and sleep. The app also measured illuminance during task completion using the smartphone's intrinsic light meter. We undertook a pilot feasibility study of Brighter Time based on 91-week-long acquisition phases within a convenience sample (recruited by local advertisements and word of mouth) running Brighter Time on their own smartphones over two study phases in winter and summer. Study compliance was suitable (median = 20/21 requested task completions per subject). Statistically significant associations were observed between subjective sleepiness and performance in all tasks. Significant daily variations in PVT and visual search performance were also observed. Higher illuminance was associated with reduced reaction time and lower inverse efficiency score in the visual search. Brighter Time thus represents a viable option for large-scale collection of cognitive task data in everyday life, and is able to reveal associations between task performance and sleepiness, time of day and current illuminance. Brighter Time's utility could be extended to exploring associations with longer-term patterns of light exposure and/or other light metrics by integrating with wearable light meters.

光是哺乳动物行为和生理状态的重要调节因子。认知表现的特征,如记忆、警觉性和警觉性,可以在实验室和现场条件下通过强光照射而改变。然而,光在日常生活中作为行为调节器的重要性很难评估,到目前为止,它在很大程度上仍不清楚。为了解决这种不确定性,我们开始开发一种工具,在日常生活中大规模地捕捉认知表现和光照的测量方法。为此,我们开发了一款应用程序(Brighter Time),其中包括精神运动警觉性(PVT)、N-back和视觉搜索任务,以及基于问卷的人口特征、总体健康状况、时型和睡眠评估。该应用程序还使用智能手机的内置测光仪测量任务完成时的照度。我们在一个方便的样本(通过当地广告和口口相传招募)中进行了为期91周的获取阶段,在冬季和夏季两个研究阶段在他们自己的智能手机上运行Brighter Time进行了试点可行性研究。研究依从性是合适的(中位数=每个受试者20/21个要求完成的任务)。主观困倦与所有任务的表现之间存在统计学上的显著关联。还观察到PVT和视觉搜索性能的显著日常变化。在视觉搜索中,较高的照度与较短的反应时间和较低的反效率得分有关。因此,“更亮的时间”为日常生活中大规模收集认知任务数据提供了一个可行的选择,并能够揭示任务表现与困倦、一天中的时间和当前照明之间的关联。通过与可穿戴式测光表集成,Brighter Time的应用可以扩展到探索与长期光照模式和/或其他光照指标的关联。
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引用次数: 3
The Intention to React to Sounds Induces Sleep Disturbances and Alters Brain Responses to Sounds during Sleep: A Pilot Study. 对声音作出反应的意图引起睡眠障碍并改变睡眠期间大脑对声音的反应:一项初步研究。
IF 3.1 Q2 Neuroscience Pub Date : 2022-10-19 DOI: 10.3390/clockssleep4040044
Selina Ladina Combertaldi, Anna Zoé Wick, Björn Rasch

Background: Pre-sleep intentions to react to stimuli during sleep affect sleep processes in spite of reductions in conscious awareness. Here, we compare influences of sounds presented during sleep (with and without intentions to react) with the effect of pre-sleep intentions on sleep (with and without sounds being present during sleep).

Methods: Twenty-six young, healthy participants spent two experimental nights in the sleep laboratory. On one night, they were instructed to react to sounds during sleep ("on call"); on the other night, not ("neutral"). Unknown to the subjects, sounds were presented at a low volume in both nights in one group. No sound was presented in any of the two nights in the other group.

Results: The instruction of being "on call" decreased objective sleep efficiency independently of sounds being present or not. In addition, event-related responses to sounds as well as slow-wave activity were reduced when being "on call".

Conclusions: Pre-sleep intentions to react impair sleep independently of sounds actually being present and influence brain responses to sounds during sleep. Our results highlight the importance of subjective relevance for reducing negative impact of external noise sources such as traffic or church bells.

背景:睡眠中对刺激反应的睡前意图影响睡眠过程,尽管意识意识减少。在这里,我们比较了睡眠中出现的声音(有和没有反应的意图)和睡前意图对睡眠的影响(有和没有在睡眠中出现的声音)。方法:26名年轻健康的参与者在睡眠实验室度过了两个实验夜。一天晚上,他们被要求在睡眠中对声音做出反应(“随叫随到”);在另一个晚上,没有(“中立”)。受试者不知道的是,其中一组在两个晚上都以低音量播放声音。另一组在两个晚上都没有声音。结果:“随叫随到”的指示降低了客观睡眠效率,与声音存在与否无关。此外,当“随叫随到”时,对声音的事件相关反应以及慢波活动都会减少。结论:睡前意图的反应会独立于声音的存在而损害睡眠,并影响睡眠期间大脑对声音的反应。我们的研究结果强调了主观相关性对于减少外部噪声源(如交通或教堂钟声)的负面影响的重要性。
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引用次数: 0
NREM Sleep Parasomnias Commencing in Childhood: Trauma and Atopy as Perpetuating Factors. 始于儿童期的 NREM 睡眠妄想症:创伤和过敏是诱发因素
IF 2.1 Q3 CLINICAL NEUROLOGY Pub Date : 2022-10-17 DOI: 10.3390/clockssleep4040043
Cara Walsh, Lee Mitchell, Maria Hrozanova, Serafeim-Chrysovalantis Kotoulas, Christopher Derry, Ian Morrison, Renata L Riha

Objective/Background: Phenotyping of non-rapid-eye-movement (NREM) parasomnias is currently poorly undertaken. This study aimed to determine whether there are differences phenotypically among childhood-, adolescent-, and adult-onset NREM parasomnias continuing into and presenting in adulthood. Patients/Methods: A retrospective, cohort study of patients presenting with NREM parasomnia between 2008 and 2019 (n = 307) was conducted. Disorders included sleepwalking (n = 231), night terrors (n = 150), sexualised behaviour in sleep (n = 50), and sleep-related eating disorder (n = 28). Results: Compared to the adult-onset NREM behaviours group, the childhood- and adolescent-onset groups were more likely to have a family history of NREM behaviours (p < 0.001), experience a greater spectrum of NREM disorders (p = 0.001), and report a history of sleep-talking significantly more frequently (p = 0.014). Atopy was most prevalent in the childhood-onset group (p = 0.001). Those with childhood-onset NREM parasomnias were significantly more likely to arouse from N3 sleep on video polysomnography (p = 0.0003). Psychiatric disorders were more likely to be comorbid in the adult-onset group (p = 0.012). A history of trauma coinciding with onset of NREM behaviours was significantly more common in the childhood- and adolescent-onset groups (p < 0.001). Conclusions: Significant differences exist across childhood-, adolescent-, and adult-onset NREM parasomnia presenting in adulthood. This study suggests that adult-onset slow-wave sleep disorders may be confounded by psychiatric disorders resulting in nocturnal sleep disruption and that unresolved traumatic life experiences perpetuate NREM disorders arising in childhood and comprise one of the strongest external risk factors for triggering and perpetuating these disorders in adolescence.

目的/背景:目前,非快速眼动(NREM)寄生虫的表型研究很少。本研究旨在确定儿童期、青少年期和成年期发病的非快速眼动(NREM)寄生虫病在表型上是否存在差异。患者/方法:对 2008 年至 2019 年期间出现 NREM 寄生虫病的患者(n = 307)进行了一项回顾性队列研究。疾病包括梦游(n = 231)、夜惊(n = 150)、睡眠中的性行为(n = 50)和睡眠相关饮食紊乱(n = 28)。研究结果与成人非快速眼动行为组相比,儿童和青少年非快速眼动行为组更有可能有非快速眼动行为家族史(p < 0.001),经历的非快速眼动障碍范围更大(p = 0.001),报告梦话史的频率更高(p = 0.014)。儿童期发病组中,过敏性鼻炎的发病率最高(p = 0.001)。患有儿童期NREM寄生虫病的患者在视频多导睡眠图上从N3睡眠中唤醒的几率明显更高(p = 0.0003)。成人发病组更有可能合并精神疾病(p = 0.012)。在儿童和青少年发病组中,在NREM行为开始的同时有外伤史的患者明显较多(p < 0.001)。结论儿童期、青少年期和成年期发病的 NREM 寄生虫性失眠症在成年后表现出显著差异。这项研究表明,成年后发病的慢波睡眠障碍可能与导致夜间睡眠中断的精神障碍有关,而未解决的创伤性生活经历会使童年时期出现的 NREM 障碍持续存在,并且是引发这些障碍并使其在青少年时期持续存在的最主要外部风险因素之一。
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引用次数: 0
STOP-Bang Score and Prediction of Severity of Obstructive Sleep Apnea in a First Nation Community in Saskatchewan, Canada. STOP-Bang评分与加拿大萨斯喀彻温省第一民族社区阻塞性睡眠呼吸暂停严重程度的预测。
IF 3.1 Q2 Neuroscience Pub Date : 2022-10-12 DOI: 10.3390/clockssleep4040042
James A Dosman, Chandima P Karunanayake, Mark Fenton, Vivian R Ramsden, Jeremy Seeseequasis, Delano Mike, Warren Seesequasis, Marie Neubuhr, Robert Skomro, Shelley Kirychuk, Donna C Rennie, Kathleen McMullin, Brooke P Russell, Niels Koehncke, Sylvia Abonyi, Malcolm King, Punam Pahwa

The STOP-Bang questionnaire is an easy-to-administer scoring model to screen and identify patients at high risk of obstructive sleep apnea (OSA). However, its diagnostic utility has never been tested with First Nation peoples. The objective was to determine the predictive parameters and the utility of the STOP-Bang questionnaire as an OSA screening tool in a First Nation community in Saskatchewan. The baseline survey of the First Nations Sleep Health Project (FNSHP) was completed between 2018 and 2019. Of the available 233 sleep apnea tests, 215 participants completed the STOP-Bang score questionnaire. A proportional odds ordinal logistic regression analysis was conducted using the total score of the STOP-Bang as the independent variable with equal weight given to each response. Predicted probabilities for each score at cut-off points of the Apnea Hypopnea Index (AHI) were calculated and plotted. To assess the performance of the STOP-Bang questionnaire, sensitivity, specificity, positive predictive values (PPVs), negative predictive values (NPVs), and area under the curve (AUC) were calculated. These data suggest that a STOP-Bang score ≥ 5 will allow healthcare professionals to identify individuals with an increased probability of moderate-to-severe OSA, with high specificity (93.7%) and NPV (91.8%). For the STOP-Bang score cut-off ≥ 3, the sensitivity was 53.1% for all OSA and 72.0% for moderate-to-severe OSA. For the STOP-Bang score cut-off ≥ 3, the specificity was 68.4% for all OSA and 62.6% for moderate-to-severe OSA. The STOP-Bang score was modestly superior to the symptom of loud snoring, or loud snoring plus obesity in this population. Analysis by sex suggested that a STOP-Bang score ≥ 5 was able to identify individuals with increased probability of moderate-to-severe OSA, for males with acceptable diagnostic test accuracy for detecting participants with OSA, but there was no diagnostic test accuracy for females.

STOP-Bang问卷是一种易于管理的评分模型,用于筛选和识别阻塞性睡眠呼吸暂停(OSA)高风险患者。然而,它的诊断效用从未在原住民身上进行过测试。目的是确定预测参数和STOP-Bang问卷作为OSA筛查工具在萨斯喀彻温省第一民族社区的效用。第一民族睡眠健康项目(FNSHP)的基线调查于2018年至2019年完成。在233项睡眠呼吸暂停测试中,215名参与者完成了STOP-Bang评分问卷。使用STOP-Bang总分作为自变量,对每个应答给予同等权重,进行比例odds序数logistic回归分析。计算并绘制呼吸暂停低通气指数(AHI)分值的预测概率。为了评估STOP-Bang问卷的性能,我们计算了敏感性、特异性、阳性预测值(PPVs)、阴性预测值(npv)和曲线下面积(AUC)。这些数据表明,STOP-Bang评分≥5将使医疗保健专业人员能够以高特异性(93.7%)和NPV(91.8%)识别中重度OSA概率增加的个体。对于STOP-Bang评分临界值≥3,所有OSA的敏感性为53.1%,中重度OSA的敏感性为72.0%。对于STOP-Bang评分截止值≥3,所有OSA的特异性为68.4%,中重度OSA的特异性为62.6%。在这个人群中,STOP-Bang评分略微优于大声打鼾的症状,或者大声打鼾加肥胖的症状。性别分析表明,STOP-Bang评分≥5能够识别出中度至重度OSA的个体,对于男性来说,诊断测试的准确性可以接受,但对于女性没有诊断测试的准确性。
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引用次数: 2
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Clocks & Sleep
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