Pub Date : 2021-10-29DOI: 10.21303/2585-6634.2021.002150
K. Ponomarova
The aim of the study: to study retrospective analysis results of the surgical treatment of thymus tumours for predicting long-time results. Methods. Study included 35 patients who were treated at the Department of Thoraco-abdominal Surgery from September 2019 to May 2021. The control group included 20 patients with SVCS were treated with conventional techniques, while the experimental group included 15 patients who underwent a novel bypass surgery developed by us. Results. The venous bypass was mandatorily complemented with cytoreduction. Complications in the post-operative period were reported from the experimental group and included auriculo-subclavian bypass thrombosis, post-operative complications were reported in the control group including haemorrhage from the sternotomy wound in 1 (3.3 %) case, superior vena cava thrombosis in 2 (6.6 %) cases, pneumonia in 2 (6.6 %). The relative risk of complications and lethal outcome was calculated for patients from both groups. It was found that the risk of complications was twice as high in the control group as in the experimental group (standard error of relative risk equals 0.64). Conclusion. The first mandatory step of the radical surgery in patients with thymomas with SVC invasion should be the auriculo-jugular and auriculo-subclavian bypasses, which can reduce the relative risk of post-operative complications by a factor of the risk of lethal by a factor of 3.5
{"title":"Peculiarities of surgical tactics of patients with thymus tumors","authors":"K. Ponomarova","doi":"10.21303/2585-6634.2021.002150","DOIUrl":"https://doi.org/10.21303/2585-6634.2021.002150","url":null,"abstract":"The aim of the study: to study retrospective analysis results of the surgical treatment of thymus tumours for predicting long-time results. \u0000Methods. Study included 35 patients who were treated at the Department of Thoraco-abdominal Surgery from September 2019 to May 2021. The control group included 20 patients with SVCS were treated with conventional techniques, while the experimental group included 15 patients who underwent a novel bypass surgery developed by us. \u0000Results. The venous bypass was mandatorily complemented with cytoreduction. Complications in the post-operative period were reported from the experimental group and included auriculo-subclavian bypass thrombosis, post-operative complications were reported in the control group including haemorrhage from the sternotomy wound in 1 (3.3 %) case, superior vena cava thrombosis in 2 (6.6 %) cases, pneumonia in 2 (6.6 %). The relative risk of complications and lethal outcome was calculated for patients from both groups. It was found that the risk of complications was twice as high in the control group as in the experimental group (standard error of relative risk equals 0.64). \u0000Conclusion. The first mandatory step of the radical surgery in patients with thymomas with SVC invasion should be the auriculo-jugular and auriculo-subclavian bypasses, which can reduce the relative risk of post-operative complications by a factor of the risk of lethal by a factor of 3.5","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78909586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-29DOI: 10.21303/2585-663.2020.001488
L. Babinets, I. Halabitska
The study of the functional capacity of the pancreas in chronic pancreatitis (CP) in comorbidity with type 2 diabetes mellitus (DM2) and primary osteoarthritis (OA) is also relevant given that patients with this combination are associated with the presence of metabolic syndrome. The aim of the study was to investigate the state of functional capacity of the pancreas in patients with comorbid chronic pancreatitis and type 2 diabetes mellitus with osteoarthritis. Material and methods. 117 patients with CP with OA with concomitant DM2 and without it were studied. The main group consisted of 92 outpatients with CP with OA in combination with diabetes in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP with primary OA, and the control group – 30 healthy individuals. Diagnoses of OA, CP and DM2 were established according to generally accepted criteria and protocols Results. Analysis of the data showed that on average in the contingent of studied patients with comorbid OA, CP and DM2 excretory insufficiency of pancreas was significantly more severe than in the group of patients with isolated CP with OA. Conclusions. In the combined course of CP and DM2 with OA, the correlation between fecal α-elastase-1 and glycosylated hemoglobin was statistically significantly stronger than in the group of patients with isolated CP, indicating a mutually aggravating effect of CP and DM2.
{"title":"INFLUENCE OF EXOCRINE PANCREATIC INSUFFICIENCY ON THE COURSE OF TYPE 2 DIABETES MELLITUS IN PATIENTS WITH PRIMARY OSTEOARTHRITIS","authors":"L. Babinets, I. Halabitska","doi":"10.21303/2585-663.2020.001488","DOIUrl":"https://doi.org/10.21303/2585-663.2020.001488","url":null,"abstract":"The study of the functional capacity of the pancreas in chronic pancreatitis (CP) in comorbidity with type 2 diabetes mellitus (DM2) and primary osteoarthritis (OA) is also relevant given that patients with this combination are associated with the presence of metabolic syndrome. The aim of the study was to investigate the state of functional capacity of the pancreas in patients with comorbid chronic pancreatitis and type 2 diabetes mellitus with osteoarthritis. Material and methods. 117 patients with CP with OA with concomitant DM2 and without it were studied. The main group consisted of 92 outpatients with CP with OA in combination with diabetes in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP with primary OA, and the control group – 30 healthy individuals. Diagnoses of OA, CP and DM2 were established according to generally accepted criteria and protocols Results. Analysis of the data showed that on average in the contingent of studied patients with comorbid OA, CP and DM2 excretory insufficiency of pancreas was significantly more severe than in the group of patients with isolated CP with OA. Conclusions. In the combined course of CP and DM2 with OA, the correlation between fecal α-elastase-1 and glycosylated hemoglobin was statistically significantly stronger than in the group of patients with isolated CP, indicating a mutually aggravating effect of CP and DM2.","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75966601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-29DOI: 10.21303/2585-663.2020.001480
N. Nestertsova, L. Nazarenko
The aim of the study was to clarify obstetric and perinatal risk in women born with low or overweight. Materials and methods. 343 women with birth weight abnormalities were examined. From them 3 groups are made, according to criterion “weight of the woman at a birth”: I – 107 women with low weight at a birth, II – 126 with excess, III – 110 people with normal weight. The anamnesis, in particular, family and own perinatal, as well as nutritional support, anthropometric data, the structure of pregnancy complications, the rate of growth and development of the fetus, perinatal results were determined. Levels of eicosapentaenoic and docosahexaenoic acids were determined as markers of nutritional support of the organism, as indicators of angiogenesis were determined – concentration of vascular endothelial growth factor and placental growth factor in blood, morpho-functional studies of placenta were performed. Results. Women born underweight are more likely to have menstrual disorders (every 4), infertility (every 10), miscarriage (every 5) and gynecological diseases. The pathology of gestation in such women and their mothers is similar in spectrum, which is an example of intrauterine programming. The implementation of this program is facilitated by negative factors of nutritional provision: inadequate breastfeeding, economical type of nutrition in favor of restricting protein foods and deviations in the process of angiogenesis. Conclusions. The importance of perinatal history as a factor that determines the increased risk of menstrual disorders, the frequency of infertility, the pathological course of gestation during pregnancy, the predisposition to placental insufficiency and the birth of a child with low weight. Women born with low birth weight and overweight are a contingent of increased perinatal risk, which is associated with a complicated own perinatal history on the background of obstetric pathology in their mothers. This fact complements the concept of intrauterine programming.
{"title":"FEATURES OF REPRODUCTIVE HEALTH OF WOMEN WITH LOW BIRTH WEIGHT AND OVERWEIGHT AT BIRTH","authors":"N. Nestertsova, L. Nazarenko","doi":"10.21303/2585-663.2020.001480","DOIUrl":"https://doi.org/10.21303/2585-663.2020.001480","url":null,"abstract":"The aim of the study was to clarify obstetric and perinatal risk in women born with low or overweight. Materials and methods. 343 women with birth weight abnormalities were examined. From them 3 groups are made, according to criterion “weight of the woman at a birth”: I – 107 women with low weight at a birth, II – 126 with excess, III – 110 people with normal weight. The anamnesis, in particular, family and own perinatal, as well as nutritional support, anthropometric data, the structure of pregnancy complications, the rate of growth and development of the fetus, perinatal results were determined. Levels of eicosapentaenoic and docosahexaenoic acids were determined as markers of nutritional support of the organism, as indicators of angiogenesis were determined – concentration of vascular endothelial growth factor and placental growth factor in blood, morpho-functional studies of placenta were performed. Results. Women born underweight are more likely to have menstrual disorders (every 4), infertility (every 10), miscarriage (every 5) and gynecological diseases. The pathology of gestation in such women and their mothers is similar in spectrum, which is an example of intrauterine programming. The implementation of this program is facilitated by negative factors of nutritional provision: inadequate breastfeeding, economical type of nutrition in favor of restricting protein foods and deviations in the process of angiogenesis. Conclusions. The importance of perinatal history as a factor that determines the increased risk of menstrual disorders, the frequency of infertility, the pathological course of gestation during pregnancy, the predisposition to placental insufficiency and the birth of a child with low weight. Women born with low birth weight and overweight are a contingent of increased perinatal risk, which is associated with a complicated own perinatal history on the background of obstetric pathology in their mothers. This fact complements the concept of intrauterine programming.","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74117189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-29DOI: 10.21303/2585-663.2020.001448
O. Shkromada, T. Nedzheria
G. duodenalis is the most widespread among the six generally recognized species of giardiasis affecting the gastrointestinal tract of mammals. Destruction of Giardia intestinalis oocysts in the environment mitigates the risk of infection for animals and humans. The objective of the study. The research is aimed at establishing the effectiveness of disinfectants against Giardia intestinalis cysts. Methods. The research involved twelve farms in Ukraine. Fecal samples were taken from the tested calves aged from 1 to 3 weeks. Giardiasis was diagnosed on the basis of laboratory tests of calf feces by the Fulleborn's method. The object of study was represented by cysts of Giardia intestinalis obtained from the feces through combined flotation methods. After exposure for a period of 30 and 60 minutes, the supernatant was drained and the precipitate applied to a glass slide to be stained with Lugol's solution. Cysts were subject to evaluation in terms of their morphological features. Their shape, size, color, nuclei location and axon were determined under a microscope at a magnification of about 10x400. Yodosol, Kontavir, Biocontact and Bioluft were used as a disinfectant. Results. The study carried out at dairy farms of various forms of ownership revealed that 25–50 % of calves at the holdings and 50–75 % of those at the farms were infected with Giardia intestinalis. Experiments established that Kontavir at a concentration of 1 %, as a disinfectant, produced a cytotoxic effect (compressed the cyst membrane) on Giardia intestinalis for 60 minutes. If the drug concentration increases to 2–3 %, Kontravir destroys the cyst shell releasing its contents within 30-60 minutes. Conclusions. The prevalence of Giardia intestinalis has been established through studying dairy farms in four regions of Ukraine. As a disinfectant, Kontavir at a concentration of 1 % produces a cytotoxic effect (compresses the cyst membrane), at a concentration of 2–3 %, it completely destroys the cyst membrane.
{"title":"INTENSITY OF INFECTION AND MEANS OF GIARDIASIS PREVENTION AT THE FARMS OF UKRAINE","authors":"O. Shkromada, T. Nedzheria","doi":"10.21303/2585-663.2020.001448","DOIUrl":"https://doi.org/10.21303/2585-663.2020.001448","url":null,"abstract":"G. duodenalis is the most widespread among the six generally recognized species of giardiasis affecting the gastrointestinal tract of mammals. Destruction of Giardia intestinalis oocysts in the environment mitigates the risk of infection for animals and humans. The objective of the study. The research is aimed at establishing the effectiveness of disinfectants against Giardia intestinalis cysts. Methods. The research involved twelve farms in Ukraine. Fecal samples were taken from the tested calves aged from 1 to 3 weeks. Giardiasis was diagnosed on the basis of laboratory tests of calf feces by the Fulleborn's method. The object of study was represented by cysts of Giardia intestinalis obtained from the feces through combined flotation methods. After exposure for a period of 30 and 60 minutes, the supernatant was drained and the precipitate applied to a glass slide to be stained with Lugol's solution. Cysts were subject to evaluation in terms of their morphological features. Their shape, size, color, nuclei location and axon were determined under a microscope at a magnification of about 10x400. Yodosol, Kontavir, Biocontact and Bioluft were used as a disinfectant. Results. The study carried out at dairy farms of various forms of ownership revealed that 25–50 % of calves at the holdings and 50–75 % of those at the farms were infected with Giardia intestinalis. Experiments established that Kontavir at a concentration of 1 %, as a disinfectant, produced a cytotoxic effect (compressed the cyst membrane) on Giardia intestinalis for 60 minutes. If the drug concentration increases to 2–3 %, Kontravir destroys the cyst shell releasing its contents within 30-60 minutes. Conclusions. The prevalence of Giardia intestinalis has been established through studying dairy farms in four regions of Ukraine. As a disinfectant, Kontavir at a concentration of 1 % produces a cytotoxic effect (compresses the cyst membrane), at a concentration of 2–3 %, it completely destroys the cyst membrane.","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82959575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-29DOI: 10.21303/2585-663.2020.001487
M. Chernenko
Cognitive functions and their disorders in patients with neurodegenerative diseases are an urgent problem of modern neurology. Such functions include memory, attention, praxis, gnosis, language, thinking, control functions. The study of the neuropsychological profile allows a more accurate picture of the involvement in the pathological process of various brain structures and thus facilitate the differential diagnosis. The aim of the research: on the basis of studying of cognitive features of patients with neurodegenerative (demyelinating) pathology to consider possibilities of their psychoneurological adaptation. Materials and methods. The survey data of 104 patients with remitting type of multiple sclerosis, who were treated at the state institution “Institute of Neurology, Psychiatry and Addiction of the National Academy of Medical Sciences of Ukraine” are presented. To study the disorders of verbal memory, the method of A. R. Luria “Memorization of 10 words” was used, which allows to estimate such parameters as the amount of direct memory and the strength of delayed memory (i.e. indicators of short-term and long-term memory). The Schulte Table method was used to study arbitrary attention disorders. This technique allows you to evaluate such characteristics of random attention as volume, functions of concentration distribution and switching of attention. Results. The data obtained indicate that, depending on the severity of relapses, there are significant differences in the course of mnestic processes. It was found that in severe variants of remissions in women with relapsing-remitting multiple sclerosis (RRMS) more pronounced than in men, there is a lack of ability to work and exhaustion. Conclusions. It is concluded that the assessment of cognitive deficit out of connection with personal characteristics and emotional and volitional disorders significantly reduces the informativeness and ability to correct cognitive dysfunction. Timely detection of cognitive and emotional-personal changes can not only improve the quality of life of patients with neurodegenerative diseases, but also act as an independent part of the psychoneurological model of adaptation of this category of patients.
{"title":"EVALUATION OF COGNITIVE FUNCTIONS IN NEURODEGENERATION","authors":"M. Chernenko","doi":"10.21303/2585-663.2020.001487","DOIUrl":"https://doi.org/10.21303/2585-663.2020.001487","url":null,"abstract":"Cognitive functions and their disorders in patients with neurodegenerative diseases are an urgent problem of modern neurology. Such functions include memory, attention, praxis, gnosis, language, thinking, control functions. The study of the neuropsychological profile allows a more accurate picture of the involvement in the pathological process of various brain structures and thus facilitate the differential diagnosis. The aim of the research: on the basis of studying of cognitive features of patients with neurodegenerative (demyelinating) pathology to consider possibilities of their psychoneurological adaptation. Materials and methods. The survey data of 104 patients with remitting type of multiple sclerosis, who were treated at the state institution “Institute of Neurology, Psychiatry and Addiction of the National Academy of Medical Sciences of Ukraine” are presented. To study the disorders of verbal memory, the method of A. R. Luria “Memorization of 10 words” was used, which allows to estimate such parameters as the amount of direct memory and the strength of delayed memory (i.e. indicators of short-term and long-term memory). The Schulte Table method was used to study arbitrary attention disorders. This technique allows you to evaluate such characteristics of random attention as volume, functions of concentration distribution and switching of attention. Results. The data obtained indicate that, depending on the severity of relapses, there are significant differences in the course of mnestic processes. It was found that in severe variants of remissions in women with relapsing-remitting multiple sclerosis (RRMS) more pronounced than in men, there is a lack of ability to work and exhaustion. Conclusions. It is concluded that the assessment of cognitive deficit out of connection with personal characteristics and emotional and volitional disorders significantly reduces the informativeness and ability to correct cognitive dysfunction. Timely detection of cognitive and emotional-personal changes can not only improve the quality of life of patients with neurodegenerative diseases, but also act as an independent part of the psychoneurological model of adaptation of this category of patients.","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77427161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-09DOI: 10.21303/2585-663.2019.001058
N. Idashkina
Delayed union of bone tissue in patients with mandibular fractures is observed in 2.4 – 26 % of clinical cases. Solution of this problem yet very much far from the final solutio and there is an urgent requirement in the comprehensive analysis of role of general and local factors of origin of delayed union MF. Methods. Modern clinical, laboratory and microbiological research methods were used in the work. Densitometry conducted on computed tomograph Planmeca Promax 3d (Finland) (85 kV 5–7 mA). The basal values of immunoglobulins of the main classes and interleukins IL-1β, FNT-α, IL-4, MDA, SOD and catalase activity, POL, β-Cross Laps and osteocalcin in peripheral blood were determined in 74 patients with delayed consolidation of the mandibular fractures. Correlation analysis of local and general (concomitant somatic pathology) factors, and clinic-laboratorial parameters in patients with delayed consolidation of the mandibular fractures is conducted. Results. There is a high correlation between β-Cross Laps (negative) and osteocalcin (positive) and bone mineral density. The mean inverse correlation relationship was established between the MDA and catalase activity and BMD (r=–0.57), and the high correlation of these indices with markers of bone remodeling (positive to β-Cross Laps (r=0.80 and r=0.87, respectively) and negative to osteocalcin (r=–0.80 and r=–0.84, respectively). High direct correlation between FNT-α indices and POL, MDA, and catalase indices, as well as very strong with β-Cross Laps (positive) and osteocalcin (negative), and also with high-correlation ligaments of sIgA and IL-1β. Discussion. Convincing clinical and laboratory data were obtained that the combined effect of local and general (concomitant somatic pathology) factors on the basis of the activation of inflammation processes, which increase the indirect influence on immune factors, processes of radical oxidation and bone metabolism, is resulted to delayed union. It was also found that clinical signs of the development of consolidation complications in patients with MF include increased signs of inflammation (oedema, exudation, etc.) up to the 3rd day and preservation of even moderate signs of inflammation (inflation, local hyperemia, and others) after the 7th day, BMD below 600 HU. Among the local factors that increase the infectious risk and inflammatory reaction, the following clinical situations should be distinguished: comminuted fracture; the presence of a tooth in the line of fractures; partially edentulous with loss of antagonist teeth (according to Eichner); complete adentia with mandible atrophy.
{"title":"DELAYED UNION OF MANDIBULAR FRACTURES: ANALYSIS OF 74 CLINICAL CASES","authors":"N. Idashkina","doi":"10.21303/2585-663.2019.001058","DOIUrl":"https://doi.org/10.21303/2585-663.2019.001058","url":null,"abstract":"Delayed union of bone tissue in patients with mandibular fractures is observed in 2.4 – 26 % of clinical cases. Solution of this problem yet very much far from the final solutio and there is an urgent requirement in the comprehensive analysis of role of general and local factors of origin of delayed union MF. Methods. Modern clinical, laboratory and microbiological research methods were used in the work. Densitometry conducted on computed tomograph Planmeca Promax 3d (Finland) (85 kV 5–7 mA). The basal values of immunoglobulins of the main classes and interleukins IL-1β, FNT-α, IL-4, MDA, SOD and catalase activity, POL, β-Cross Laps and osteocalcin in peripheral blood were determined in 74 patients with delayed consolidation of the mandibular fractures. Correlation analysis of local and general (concomitant somatic pathology) factors, and clinic-laboratorial parameters in patients with delayed consolidation of the mandibular fractures is conducted. Results. There is a high correlation between β-Cross Laps (negative) and osteocalcin (positive) and bone mineral density. The mean inverse correlation relationship was established between the MDA and catalase activity and BMD (r=–0.57), and the high correlation of these indices with markers of bone remodeling (positive to β-Cross Laps (r=0.80 and r=0.87, respectively) and negative to osteocalcin (r=–0.80 and r=–0.84, respectively). High direct correlation between FNT-α indices and POL, MDA, and catalase indices, as well as very strong with β-Cross Laps (positive) and osteocalcin (negative), and also with high-correlation ligaments of sIgA and IL-1β. Discussion. Convincing clinical and laboratory data were obtained that the combined effect of local and general (concomitant somatic pathology) factors on the basis of the activation of inflammation processes, which increase the indirect influence on immune factors, processes of radical oxidation and bone metabolism, is resulted to delayed union. It was also found that clinical signs of the development of consolidation complications in patients with MF include increased signs of inflammation (oedema, exudation, etc.) up to the 3rd day and preservation of even moderate signs of inflammation (inflation, local hyperemia, and others) after the 7th day, BMD below 600 HU. Among the local factors that increase the infectious risk and inflammatory reaction, the following clinical situations should be distinguished: comminuted fracture; the presence of a tooth in the line of fractures; partially edentulous with loss of antagonist teeth (according to Eichner); complete adentia with mandible atrophy.","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73844412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-09DOI: 10.21303/2585-663.2019.001050
V. Tseluyko, L. Yakovleva, Fedia ben Salem
Our aim was to study the predictive value of NT proBNP regarding the risk of AF and clinical features in acute phase of ST-segment elevation MI (STEMI). Methods. We examined 56 patients with STEMI and AF who did undergo the primary PCI. 35 (62.5 %) of patients had the new-onset AF (group 1), 21 (37.5 %) had pre-existing AF (group 2). Control group consisted of 60 patients with STEMI without AF (group 3). Results. Group 3 patients were more likely to be smokers than patients in group 2. They had lower admission heart rate and glycemia, lower NT proBNP, higher hemoglobin and ejection fraction. Patients in group 1 were more likely to have anterior MI, left anterior descending artery as an infarction-related artery (IRA) and adverse cardiac events (MACEs). Patients in group 2 had higher left atrium end-systolic diameter and were more likely to have three-vessel injury. NT proBNP correlated positively with age, admission glycemia, mean PA pressure and negatively – with GFR. ROC analysis had shown the cut-off point of NT proBNP level for prediction of AF was >1050 pg/ml. Cut-off point for prediction of the risk of MACE in STEMI complicated with AF was >2189 pg/ml. Discussion. It was shown that NT proBNP is higher in STEMI patients who have AF. Increased NT proBNP is associated with the risk of adverse events in acute STEMI phase. NT proBNP level can be utilized as AF predictor in STEMI patients and as predictor of MACEs in patients with STEMI and AF.
{"title":"CLINICAL IMPLICATIONS OF NT PROBNP LEVEL IN PATIENTS WITH MYOCARDIAL INFARCTION COMPLICATED BY ATRIAL FIBRILLATION","authors":"V. Tseluyko, L. Yakovleva, Fedia ben Salem","doi":"10.21303/2585-663.2019.001050","DOIUrl":"https://doi.org/10.21303/2585-663.2019.001050","url":null,"abstract":"Our aim was to study the predictive value of NT proBNP regarding the risk of AF and clinical features in acute phase of ST-segment elevation MI (STEMI). Methods. We examined 56 patients with STEMI and AF who did undergo the primary PCI. 35 (62.5 %) of patients had the new-onset AF (group 1), 21 (37.5 %) had pre-existing AF (group 2). Control group consisted of 60 patients with STEMI without AF (group 3). Results. Group 3 patients were more likely to be smokers than patients in group 2. They had lower admission heart rate and glycemia, lower NT proBNP, higher hemoglobin and ejection fraction. Patients in group 1 were more likely to have anterior MI, left anterior descending artery as an infarction-related artery (IRA) and adverse cardiac events (MACEs). Patients in group 2 had higher left atrium end-systolic diameter and were more likely to have three-vessel injury. NT proBNP correlated positively with age, admission glycemia, mean PA pressure and negatively – with GFR. ROC analysis had shown the cut-off point of NT proBNP level for prediction of AF was >1050 pg/ml. Cut-off point for prediction of the risk of MACE in STEMI complicated with AF was >2189 pg/ml. Discussion. It was shown that NT proBNP is higher in STEMI patients who have AF. Increased NT proBNP is associated with the risk of adverse events in acute STEMI phase. NT proBNP level can be utilized as AF predictor in STEMI patients and as predictor of MACEs in patients with STEMI and AF.","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75431421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-09DOI: 10.21303/2585-663.2019.001059
Y. Shushkovska, O. Afanasiuk
One of the pressing problems of modern cardiology is the study of the etiological and risk factors for sudden cardiac death (SCD). Arrhythmias, which in most cases correlate with signs of myocardial hypertrophy, are important for its occurrence. The most common cause of left ventricular hypertrophy (LVH) is hypertension. However, an equally important trigger mechanism for malignant arrhythmias is coronary heart disease (CHD). It is known that LVH is considered as an independent risk factor for cardiovascular complications. Methods. The study design included an assessment of the effect of cardiac remodelling, the degree of LVH, and the degree of dilatation of left atrium (LA) on the development of malignant disorders of rhythm and conduction of the heart (DRCH). 78 patients with II degree of hypertension were examined. Patients were divided into two groups depending on the presence of CHD. In each group, there were malignant rhythm and conduction disorders. The control group consisted of 20 healthy people. Results and discussion. The stages of LVH were equally represented in both groups, but the concentric LVH, the initial degree of LVH, and the dilatation of LA predominated. In patients with malignant DRCH, a moderate degree of LVH predominated. Significantly, more likely malignant DRCH occurred in the second group and presented with high-grade ventricular extrasystoles, prolonged QT interval, and sinus node weakness syndrome.
{"title":"LEFT VENTRICULAR HYPERTROPHY AND LEFT ATRIAL DILATATION AS MARKERS OF MALIGNANT ARRHYTHMIAS DEVELOPMENT","authors":"Y. Shushkovska, O. Afanasiuk","doi":"10.21303/2585-663.2019.001059","DOIUrl":"https://doi.org/10.21303/2585-663.2019.001059","url":null,"abstract":"One of the pressing problems of modern cardiology is the study of the etiological and risk factors for sudden cardiac death (SCD). Arrhythmias, which in most cases correlate with signs of myocardial hypertrophy, are important for its occurrence. The most common cause of left ventricular hypertrophy (LVH) is hypertension. However, an equally important trigger mechanism for malignant arrhythmias is coronary heart disease (CHD). It is known that LVH is considered as an independent risk factor for cardiovascular complications. Methods. The study design included an assessment of the effect of cardiac remodelling, the degree of LVH, and the degree of dilatation of left atrium (LA) on the development of malignant disorders of rhythm and conduction of the heart (DRCH). 78 patients with II degree of hypertension were examined. Patients were divided into two groups depending on the presence of CHD. In each group, there were malignant rhythm and conduction disorders. The control group consisted of 20 healthy people. Results and discussion. The stages of LVH were equally represented in both groups, but the concentric LVH, the initial degree of LVH, and the dilatation of LA predominated. In patients with malignant DRCH, a moderate degree of LVH predominated. Significantly, more likely malignant DRCH occurred in the second group and presented with high-grade ventricular extrasystoles, prolonged QT interval, and sinus node weakness syndrome.","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"331 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75239284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-09DOI: 10.21303/2585-663.2019.001069
S. Semenenko, A. Semenenko
The development and introduction into practice of emergency neurology of new drugs capable of influencing secondary neuronal damage in patients with traumatic brain injury (TBI) has made a significant impact on the recovery of such patients. Aim of the work was to evaluate the magnitude of cerebroprotective action of amantadine sulfate in terms of impaired carbohydrate metabolism of the brain against the background of experimental TBI. Materials and methods. The experimental model of severe TBI was caused by the action of a carbon dioxide flow under pressure, which was created using a gas balloon of pneumatic gun. The therapeutic effect of amantadine sulfate on TBI model was evaluated with a 5 mg/kg dose. The pseudo-operated animals and control group received 0.9 % NaCl solution at a dose of 2 ml/kg with IV administration. Results. The obtained results confirm the formation of a hypo-energetic state in the brain cells of rats on the background of TBI, which is probably a consequence of the suppression of the processes of oxidative phosphorylation and its conjugation with tissue respiration. TBI is accompanied by activation of anaerobic glycolysis and inhibition of aerobic glucose oxidation, proving that there is an imbalance between the levels of lactate and pyruvate intermediates. 8-day infusion of rats with traumatic brain injury of amantadine sulfate, inhibited anaerobic glycolysis hyperactivation, stimulated tissue respiration processes, reduced signs of lactic acidosis and development of secondary alteration of brain cells by non-oxidized products. Conclusions. In the course of the experiment, it was found that the treatment of rats, with TBI model, with 0.9 % NaCl solution did not significantly contribute to the restoration of impaired energy metabolism (p<0.05) and did not reduce the manifestation of metabolic acidosis in the damaged brain (p<0.05). The use of amantadine sulphate in TBI rats significantly corrects carbohydrate metabolism disorders than 0.9 % NaCl solution and contributes to the reduction of metabolic acidosis in the damaged brain (p<0.05).
{"title":"EFFECTIVENESS OF CORRECTION OF DISCUSSION OF CARBOHYDRATE METABOLISM IN RATS WITH CRANIOCEREBRAL INJURY","authors":"S. Semenenko, A. Semenenko","doi":"10.21303/2585-663.2019.001069","DOIUrl":"https://doi.org/10.21303/2585-663.2019.001069","url":null,"abstract":"The development and introduction into practice of emergency neurology of new drugs capable of influencing secondary neuronal damage in patients with traumatic brain injury (TBI) has made a significant impact on the recovery of such patients. Aim of the work was to evaluate the magnitude of cerebroprotective action of amantadine sulfate in terms of impaired carbohydrate metabolism of the brain against the background of experimental TBI. Materials and methods. The experimental model of severe TBI was caused by the action of a carbon dioxide flow under pressure, which was created using a gas balloon of pneumatic gun. The therapeutic effect of amantadine sulfate on TBI model was evaluated with a 5 mg/kg dose. The pseudo-operated animals and control group received 0.9 % NaCl solution at a dose of 2 ml/kg with IV administration. Results. The obtained results confirm the formation of a hypo-energetic state in the brain cells of rats on the background of TBI, which is probably a consequence of the suppression of the processes of oxidative phosphorylation and its conjugation with tissue respiration. TBI is accompanied by activation of anaerobic glycolysis and inhibition of aerobic glucose oxidation, proving that there is an imbalance between the levels of lactate and pyruvate intermediates. 8-day infusion of rats with traumatic brain injury of amantadine sulfate, inhibited anaerobic glycolysis hyperactivation, stimulated tissue respiration processes, reduced signs of lactic acidosis and development of secondary alteration of brain cells by non-oxidized products. Conclusions. In the course of the experiment, it was found that the treatment of rats, with TBI model, with 0.9 % NaCl solution did not significantly contribute to the restoration of impaired energy metabolism (p<0.05) and did not reduce the manifestation of metabolic acidosis in the damaged brain (p<0.05). The use of amantadine sulphate in TBI rats significantly corrects carbohydrate metabolism disorders than 0.9 % NaCl solution and contributes to the reduction of metabolic acidosis in the damaged brain (p<0.05).","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73683117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-09DOI: 10.21303/2585-663.2019.001095
L. Semeniuk, L. Demianenko
According to the Princeton Consensus, female sexual dysfunction can be a sign of androgen deficiency (AD) in women of reproductive age, which necessitates the inclusion of appropriate therapy in fertility rehabilitation protocols for patients with biochemically confirmed AD. Most often, AD is associated with ovarian dysfunction. With ovarian hypofunction of autoimmune origin, an increase in inhibin B production occurs, in contrast to ovarian insufficiency of another etiology, which is due to selective damage to theca interna cells, while granulosa cells synthesizing inhibin B remain intact. Aim of the research. The study of the value of inhibin B as a prognostic marker of fertility recovery in women with androgen deficiency and sexual dysfunction. Materials and methods. The study design included 77 women of reproductive age of the main group with sexual dysfunction and androgen deficiency: 45 women with sexual dysfunction and the presence of thyroperoxidase Ak (I-a group), I-b group of 32 women with sexual dysfunction without antibodies to any organism tissues. Control group – 31 healthy women of reproductive age. Diagnostic laparoscopy was performed on anOLYMPUS device using a standard technique. Hormone testing was performed using a Johnson & Johnson Vitros automated system. Blood samples for the study were taken in the morning (8–11) on an empty stomach with venipuncture of the ulnar vein in the 1st phase of the menstrual cycle. Ultrasound test was performed on an Aloka Hitachi apparatus (Japan) with a sensor frequency of 7 MHz. Sexual dysfunction was determined by the Skindex-16V questionnaire. The diagnosis of the examined “Violation of female sexual desire / arousal” was done according to the classification DSM-5. Clinical manifestation of sexual dysfunction was >6 months. Results. The average age of the examined main group was 32.3±1.7 years, in the control group – 33.9±1.6 years. The average age of menarche for women of both groups was 13–14 years (in the main 13.3±0.34, in the control – 13.0±0.23 (p>0.05). The study of the hormonal background showed a pronounced, statistically significant in compare with healthy women, a decrease in the concentrations of not only estradiol, but also androgens, total testosterone, free testosterone, as well as dehydroepiandrosterone sulfate. Concentrations of sex steroids directly and statistically significantly correlated with the I-a group with concentrations of gonadotropins (luteinizing hormone (LH) and estradiol r=0.67; follicle-stimulating hormone (FSH) and estradiol r=0.64; LH and total testosterone r=0.47; FSH and total testosterone r=0.42; for all p <0.001). LH and DHEA-S p=0 <33 (p=0 <02), FSH and DHEA-S p=0<27 (p=0 <03). In group I-b, LH correlation and total testosterone r=0.58 p<0.001 were noted. Diagnostic laparoscopy with ovarian biopsy was performed in 12 women of group I-a and group 23 of group I-b. At the same time, the presence of lymphoid infiltration, autoantibodies and complement on
{"title":"INHIBIN B AS MARKER OF ANDROGEN INSUFFICIENCY IN WOMEN OF REPRODUCTIVE AGE WITH SEXUAL DYSFUNCTION","authors":"L. Semeniuk, L. Demianenko","doi":"10.21303/2585-663.2019.001095","DOIUrl":"https://doi.org/10.21303/2585-663.2019.001095","url":null,"abstract":"According to the Princeton Consensus, female sexual dysfunction can be a sign of androgen deficiency (AD) in women of reproductive age, which necessitates the inclusion of appropriate therapy in fertility rehabilitation protocols for patients with biochemically confirmed AD. Most often, AD is associated with ovarian dysfunction. With ovarian hypofunction of autoimmune origin, an increase in inhibin B production occurs, in contrast to ovarian insufficiency of another etiology, which is due to selective damage to theca interna cells, while granulosa cells synthesizing inhibin B remain intact. Aim of the research. The study of the value of inhibin B as a prognostic marker of fertility recovery in women with androgen deficiency and sexual dysfunction. Materials and methods. The study design included 77 women of reproductive age of the main group with sexual dysfunction and androgen deficiency: 45 women with sexual dysfunction and the presence of thyroperoxidase Ak (I-a group), I-b group of 32 women with sexual dysfunction without antibodies to any organism tissues. Control group – 31 healthy women of reproductive age. Diagnostic laparoscopy was performed on anOLYMPUS device using a standard technique. Hormone testing was performed using a Johnson & Johnson Vitros automated system. Blood samples for the study were taken in the morning (8–11) on an empty stomach with venipuncture of the ulnar vein in the 1st phase of the menstrual cycle. Ultrasound test was performed on an Aloka Hitachi apparatus (Japan) with a sensor frequency of 7 MHz. Sexual dysfunction was determined by the Skindex-16V questionnaire. The diagnosis of the examined “Violation of female sexual desire / arousal” was done according to the classification DSM-5. Clinical manifestation of sexual dysfunction was >6 months. Results. The average age of the examined main group was 32.3±1.7 years, in the control group – 33.9±1.6 years. The average age of menarche for women of both groups was 13–14 years (in the main 13.3±0.34, in the control – 13.0±0.23 (p>0.05). The study of the hormonal background showed a pronounced, statistically significant in compare with healthy women, a decrease in the concentrations of not only estradiol, but also androgens, total testosterone, free testosterone, as well as dehydroepiandrosterone sulfate. Concentrations of sex steroids directly and statistically significantly correlated with the I-a group with concentrations of gonadotropins (luteinizing hormone (LH) and estradiol r=0.67; follicle-stimulating hormone (FSH) and estradiol r=0.64; LH and total testosterone r=0.47; FSH and total testosterone r=0.42; for all p <0.001). LH and DHEA-S p=0 <33 (p=0 <02), FSH and DHEA-S p=0<27 (p=0 <03). In group I-b, LH correlation and total testosterone r=0.58 p<0.001 were noted. Diagnostic laparoscopy with ovarian biopsy was performed in 12 women of group I-a and group 23 of group I-b. At the same time, the presence of lymphoid infiltration, autoantibodies and complement on ","PeriodicalId":33846,"journal":{"name":"Technology Transfer Innovative Solutions in Medicine","volume":"389 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73136395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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