Pub Date : 2025-06-01DOI: 10.1016/j.radmp.2025.05.002
Haiying Wang, Weijin Zou, Yi Cao
Cellular responses to radiation exposure involve complex and dynamic signaling networks that coordinately regulate cell fate. Senescent cells exhibit irreversible growth arrest and functional alterations, while adaptive response confers cellular protection against subsequent radiation insults. The intricate interplay between the two processes influences radiation resistance and genomic stability, with implications for understanding molecular mechanisms of radiotherapy and cellular stress responses. This review systematically investigates the molecular triggers and signaling pathways underlying radiation-induced cellular senescence and adaptive response, and elucidates the molecular interactions between these phenomena. The findings have significant implications for understanding of cellular stress responses, optimizing radiotherapy protocols, and mitigating radiation-induced cellular dysfunction.
{"title":"Radiation-induced cellular senescence and adaptive response: mechanistic interplay and implications","authors":"Haiying Wang, Weijin Zou, Yi Cao","doi":"10.1016/j.radmp.2025.05.002","DOIUrl":"10.1016/j.radmp.2025.05.002","url":null,"abstract":"<div><div>Cellular responses to radiation exposure involve complex and dynamic signaling networks that coordinately regulate cell fate. Senescent cells exhibit irreversible growth arrest and functional alterations, while adaptive response confers cellular protection against subsequent radiation insults. The intricate interplay between the two processes influences radiation resistance and genomic stability, with implications for understanding molecular mechanisms of radiotherapy and cellular stress responses. This review systematically investigates the molecular triggers and signaling pathways underlying radiation-induced cellular senescence and adaptive response, and elucidates the molecular interactions between these phenomena. The findings have significant implications for understanding of cellular stress responses, optimizing radiotherapy protocols, and mitigating radiation-induced cellular dysfunction.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 132-139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.radmp.2025.04.001
Jie Chen , Lou Liu , Yi Fu, Lu Zhang, Shuyue Li, Juying Zhou, Chenying Ma
Objective
To predict the recurrence risk of cervical cancer after radiotherapy using multi-sequence magnetic resonance imaging (MRI) radiomics.
Methods
A total of 90 cervical cancer patients treated in the First Affiliated Hospital of Soochow University from January 2018 to January 2023 were enrolled in this retrospective study, comprising 29 cases with recurrence and 61 cases without recurrence. The cohort was divided into a training set of 60 cases and a test set of 30 cases. Tumor regions of interest (ROI) were delineated using MRI radiomics scans before and after treatment, and image features were extracted to build predictive models. Ten models were used to predict recurrence risk in the test set, named as combined model T1-weighted imaging (T1WI) sequence, combined model fast gradient-recalled echo (FGRE) sequence, combined model T2 fat suppression sequence, combined model-epi sequence, FGRE sequence-T1WI sequence model, FGRE sequence-T2 fat suppression sequence, FGRE sequence-epi sequence model, T2 fat suppression sequence-T1WI sequence model, T2 fat suppression sequence-epi sequence model and the combined multi-sequence model.
Results
In the training set, compared with the combined multi-sequence model, the receiver operating characteristic (ROC) curves of the T1WI sequence, FGRE sequence, and T2 fat suppression sequence combined with the T1WI sequence model were significantly different (Z = 2.25, 2.66,2.54, P < 0.05). In the test set, the ROC curve of the T1WI sequence model also showed a statistically significant difference from the combined model (Z = 2.21, P < 0.05). The T1WI sequence, FGRE sequence, T2 fat suppression sequence, EPI sequence, and the combined model were all effective in predicting post-radiotherapy cervical cancer recurrence [area under curve (AUC) = 0.731, 0.705, 0.823, 0.754, 0.871, P < 0.05]. Compared with the single-sequence models, the combined multi-sequence model showed the highest AUC value, accuracy, and precision in the ROC curve (AUC = 0.854, P < 0.05).
Conclusion
Multi-sequence MRI radiomics could effectively predict the risk of cervical cancer recurrence after radiotherapy, and the combined multi-sequence model demonstrates enhanced predictive performance.
目的应用多序列磁共振成像（MRI）放射组学技术预测宫颈癌放疗后复发风险。方法回顾性分析2018年1月至2023年1月苏州大学第一附属医院收治的90例宫颈癌患者，其中复发29例，未复发61例。该队列分为训练组60例和测试组30例。在治疗前后使用MRI放射组学扫描描绘肿瘤感兴趣区域（ROI），并提取图像特征以建立预测模型。使用10个模型预测测试集中的复发风险，分别为组合模型t1加权成像（T1WI）序列、组合模型快速梯度回忆回波（FGRE）序列、组合模型T2脂肪抑制序列、组合模型-epi序列、FGRE序列-T1WI序列模型、FGRE序列-T2脂肪抑制序列、FGRE序列-epi序列模型、T2脂肪抑制序列-T1WI序列模型。T2脂肪抑制序列-epi序列模型及多序列组合模型。结果在训练集中，与多序列联合模型相比，T1WI序列、FGRE序列和T2脂肪抑制序列与T1WI序列模型联合的受试者工作特征（ROC）曲线差异有统计学意义(Z = 2.25、2.66、2.54,P <；0.05)。在检验集中，T1WI序列模型的ROC曲线与组合模型的差异也有统计学意义(Z = 2.21, P <；0.05)。T1WI序列、FGRE序列、T2脂肪抑制序列、EPI序列及联合模型预测放疗后宫颈癌复发均有效[曲线下面积(AUC) = 0.731、0.705、0.823、0.754、0.871,P <；0.05]。与单序列模型相比，多序列组合模型在ROC曲线上的AUC值、准确度和精密度最高(AUC = 0.854, P <；0.05)。结论多序列MRI放射组学可有效预测宫颈癌放疗后复发风险，多序列联合模型预测效果更佳。
{"title":"Prediction of recurrence risk of cervical cancer after radiotherapy using multi-sequence MRI radiomics","authors":"Jie Chen , Lou Liu , Yi Fu, Lu Zhang, Shuyue Li, Juying Zhou, Chenying Ma","doi":"10.1016/j.radmp.2025.04.001","DOIUrl":"10.1016/j.radmp.2025.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>To predict the recurrence risk of cervical cancer after radiotherapy using multi-sequence magnetic resonance imaging (MRI) radiomics.</div></div><div><h3>Methods</h3><div>A total of 90 cervical cancer patients treated in the First Affiliated Hospital of Soochow University from January 2018 to January 2023 were enrolled in this retrospective study, comprising 29 cases with recurrence and 61 cases without recurrence. The cohort was divided into a training set of 60 cases and a test set of 30 cases. Tumor regions of interest (ROI) were delineated using MRI radiomics scans before and after treatment, and image features were extracted to build predictive models. Ten models were used to predict recurrence risk in the test set, named as combined model T1-weighted imaging (T1WI) sequence, combined model fast gradient-recalled echo (FGRE) sequence, combined model T2 fat suppression sequence, combined model-epi sequence, FGRE sequence-T1WI sequence model, FGRE sequence-T2 fat suppression sequence, FGRE sequence-epi sequence model, T2 fat suppression sequence-T1WI sequence model, T2 fat suppression sequence-epi sequence model and the combined multi-sequence model.</div></div><div><h3>Results</h3><div>In the training set, compared with the combined multi-sequence model, the receiver operating characteristic (ROC) curves of the T1WI sequence, FGRE sequence, and T2 fat suppression sequence combined with the T1WI sequence model were significantly different (<em>Z</em> = 2.25, 2.66,2.54, <em>P</em> < 0.05). In the test set, the ROC curve of the T1WI sequence model also showed a statistically significant difference from the combined model (<em>Z</em> = 2.21, <em>P</em> < 0.05). The T1WI sequence, FGRE sequence, T2 fat suppression sequence, EPI sequence, and the combined model were all effective in predicting post-radiotherapy cervical cancer recurrence [area under curve (AUC) = 0.731, 0.705, 0.823, 0.754, 0.871, <em>P</em> < 0.05]. Compared with the single-sequence models, the combined multi-sequence model showed the highest AUC value, accuracy, and precision in the ROC curve (AUC = 0.854, <em>P</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>Multi-sequence MRI radiomics could effectively predict the risk of cervical cancer recurrence after radiotherapy, and the combined multi-sequence model demonstrates enhanced predictive performance.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 169-174"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To perform a comprehensive physical-level assessment of 13 contrast agents, including those with potential applications in CT imaging, focusing on their radiation shielding characteristics and transport behaviors—such as energy deposition, collision frequency, and attenuation performance—under low-energy X-ray conditions.
Methods
A dual-method framework was adopted. Geant4 Monte Carlo simulations were used to construct an X-ray tube model and simulate contrast agent interactions in a breast-equivalent water phantom, enabling analysis of microscopic radiation transport parameters including energy deposition, track length, and collision frequency. In parallel, Phy-X/PSD software was used to calculate macroscopic attenuation indices, including the linear attenuation coefficient (LAC), mass attenuation coefficient (MAC), mean free path (MFP), half-value layer (HVL), and exposure buildup factor (EBF), over a wide photon energy range.
Results
The study revealed a strong consistency between radiation shielding metrics and transport characteristics across the same energy ranges. For instance, iothalamate meglumine exhibited the highest energy deposition (0.085 60 MeV), shortest MFP (1.13 cm), and highest collision frequency (5.24 × 108), indicating excellent attenuation potential in the low-energy CT range. Gadolinium- and iron-based agents, while traditionally used in MR imaging, showed distinctive and stable transport behavior at medium-to-high energies, suggesting promising utility in CT or dual-modality applications.
Conclusions
These findings highlight the importance of integrating microscopic transport analysis with macroscopic shielding evaluation to fully characterize contrast agent performance. The study provides a validated theoretical foundation for contrast agent screening and optimization in X-ray imaging, and supports future research into clinical applicability and biological safety of emerging contrast materials.
{"title":"Comprehensive physical evaluation of potential CT contrast agents: Integrating Monte Carlo transport simulation and radiation shielding Analysis","authors":"Yadong Zhang, Jinjia Cao, Yulong Zhang, Xiaochang Zheng, Wei Chen, Yanjun Wang","doi":"10.1016/j.radmp.2025.04.005","DOIUrl":"10.1016/j.radmp.2025.04.005","url":null,"abstract":"<div><h3>Objective</h3><div>To perform a comprehensive physical-level assessment of 13 contrast agents, including those with potential applications in CT imaging, focusing on their radiation shielding characteristics and transport behaviors—such as energy deposition, collision frequency, and attenuation performance—under low-energy X-ray conditions.</div></div><div><h3>Methods</h3><div>A dual-method framework was adopted. Geant4 Monte Carlo simulations were used to construct an X-ray tube model and simulate contrast agent interactions in a breast-equivalent water phantom, enabling analysis of microscopic radiation transport parameters including energy deposition, track length, and collision frequency. In parallel, Phy-X/PSD software was used to calculate macroscopic attenuation indices, including the linear attenuation coefficient (LAC), mass attenuation coefficient (MAC), mean free path (MFP), half-value layer (HVL), and exposure buildup factor (EBF), over a wide photon energy range.</div></div><div><h3>Results</h3><div>The study revealed a strong consistency between radiation shielding metrics and transport characteristics across the same energy ranges. For instance, iothalamate meglumine exhibited the highest energy deposition (0.085 60 MeV), shortest MFP (1.13 cm), and highest collision frequency (5.24 × 10<sup>8</sup>), indicating excellent attenuation potential in the low-energy CT range. Gadolinium- and iron-based agents, while traditionally used in MR imaging, showed distinctive and stable transport behavior at medium-to-high energies, suggesting promising utility in CT or dual-modality applications.</div></div><div><h3>Conclusions</h3><div>These findings highlight the importance of integrating microscopic transport analysis with macroscopic shielding evaluation to fully characterize contrast agent performance. The study provides a validated theoretical foundation for contrast agent screening and optimization in X-ray imaging, and supports future research into clinical applicability and biological safety of emerging contrast materials.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 175-182"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.radmp.2025.04.003
Chen Li , Liqiu Ma
Radiation-induced vascular damage has attracted significant attention in various fields, including healthcare (radiotherapy), the nuclear industry (nuclear facilities and devices), and space exploration. Recent studies have indicated a close relationship between such damage and aging, involving multiple signaling pathways and biological targets. This review aims to summarize the potential mechanisms underlying radiation-induced vascular damage, explore key molecular targets and related signaling pathways during the aging process, and provide a theoretical foundation for developing future therapeutic strategies. The review discusses direct mechanisms of radiation-induced vascular damage, such as apoptosis, necrosis, endothelial dysfunction, and alterations in the extracellular matrix. It also delves into the biological links between vascular damage and aging, including changes in the expression of aging markers, telomere shortening, and immune responses. Key molecular targets, such as the p53 pathway, nuclear factor-kappa B (NF-κB) signaling pathway, and silent information regulator 2-related enzyme 1 (SIRT1), are examined for their roles in mediating vascular damage and aging. Additionally, major signaling pathways such as MAPK, PI3K/Akt, and Wnt/β-catenin are analyzed for their involvement in cellular stress responses and vascular repair mechanisms. The review also summarizes the evaluation of current clinical treatments, discusses the potential therapeutic value of new targets, and outlines future research directions and challenges in the field.
{"title":"Radiation-induced vascular damage and aging: a review of potential therapeutic targets and key signaling pathways","authors":"Chen Li , Liqiu Ma","doi":"10.1016/j.radmp.2025.04.003","DOIUrl":"10.1016/j.radmp.2025.04.003","url":null,"abstract":"<div><div>Radiation-induced vascular damage has attracted significant attention in various fields, including healthcare (radiotherapy), the nuclear industry (nuclear facilities and devices), and space exploration. Recent studies have indicated a close relationship between such damage and aging, involving multiple signaling pathways and biological targets. This review aims to summarize the potential mechanisms underlying radiation-induced vascular damage, explore key molecular targets and related signaling pathways during the aging process, and provide a theoretical foundation for developing future therapeutic strategies. The review discusses direct mechanisms of radiation-induced vascular damage, such as apoptosis, necrosis, endothelial dysfunction, and alterations in the extracellular matrix. It also delves into the biological links between vascular damage and aging, including changes in the expression of aging markers, telomere shortening, and immune responses. Key molecular targets, such as the p53 pathway, nuclear factor-kappa B (NF-κB) signaling pathway, and silent information regulator 2-related enzyme 1 (SIRT1), are examined for their roles in mediating vascular damage and aging. Additionally, major signaling pathways such as MAPK, PI3K/Akt, and Wnt/β-catenin are analyzed for their involvement in cellular stress responses and vascular repair mechanisms. The review also summarizes the evaluation of current clinical treatments, discusses the potential therapeutic value of new targets, and outlines future research directions and challenges in the field.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 140-146"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.radmp.2025.03.001
Xindi Wei , Wei Chen , Jin Wang , Zihao Zhang , Yuji Miao , Yuanyuan Zhou , Xiangyong Fan , Jinhan Wang , Yeqing Gu
Objective
To investigate the relationship between occupational X-ray exposure and cancer risk in medical X-ray diagnostic workers, a cohort study was conducted in medical X-ray diagnostic workers in Jiangsu province, China, based on Chinese Medical X-ray Workers Cohort, in order to provide scientific evidence for the improvement of occupational radiation protection in medical X-ray diagnostic workers.
Methods
From 2011 to 2021, a retrospective cohort study was conducted in 2,984 medical X-ray diagnostic workers who worked in the radiology departments of all hospitals in Jiangsu during 1950–1980 and were alive by June 30, 2011 (radiation group) and 2,601 medical workers who worked in other departments of the same hospitals during the same period and were alive by June 30, 2011 (control group). Basic information and cancer incidence were collected from the study participants. The person-years of observation in the study participants during 2011–2021 was calculated. Cox regression model was used to calculate the relative risk for cancers such as solid cancer, lung cancer, and lymphomas in the radiation group after adjustment for sex, age, year of birth, and year to start working, and stratified analyses on the risks for total cancer and solid cancer in the radiation group were performed for confounders such as sex.
Results
The total number of person-years of follow-up was 52,327, and the loss to follow-up rate was 3.15%. A total of 544 cancer cases were detected in follow-up during this period. Compared with the control group, the hazard ratio (HR) of total cancer was 1.13 (95% CI: 0.93–1.37), and the HR of solid cancer was 1.11 (95% CI: 0.91–1.36) in the radiation group. Compared with the control group, the radiation group had significantly higher risk for lymphoma (HR = 10.36, 95% CI:1.27–84.27). Stratified analyses showed that the medical X-ray workers who started to working before 1970 had higher risks for solid cancer (HR = 1.26, 95% CI:1.01–1.59) and total cancer (HR = 1.29, 95% CI:1.04–1.62) compared with those who started working after 1970.
Conclusion
The risk for lymphoma was high in the medical X-ray workers in Jiangsu, suggesting that it is necessaryt to strengthen the occupational radiation protection for medical X-ray workers.
{"title":"Analysis on occupational exposure associated cancer risk in medical X-ray diagnostic workers in Jiangsu province, China, 2011–2021: A cohort study","authors":"Xindi Wei , Wei Chen , Jin Wang , Zihao Zhang , Yuji Miao , Yuanyuan Zhou , Xiangyong Fan , Jinhan Wang , Yeqing Gu","doi":"10.1016/j.radmp.2025.03.001","DOIUrl":"10.1016/j.radmp.2025.03.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between occupational X-ray exposure and cancer risk in medical X-ray diagnostic workers, a cohort study was conducted in medical X-ray diagnostic workers in Jiangsu province, China, based on Chinese Medical X-ray Workers Cohort, in order to provide scientific evidence for the improvement of occupational radiation protection in medical X-ray diagnostic workers.</div></div><div><h3>Methods</h3><div>From 2011 to 2021, a retrospective cohort study was conducted in 2,984 medical X-ray diagnostic workers who worked in the radiology departments of all hospitals in Jiangsu during 1950–1980 and were alive by June 30, 2011 (radiation group) and 2,601 medical workers who worked in other departments of the same hospitals during the same period and were alive by June 30, 2011 (control group). Basic information and cancer incidence were collected from the study participants. The person-years of observation in the study participants during 2011–2021 was calculated. Cox regression model was used to calculate the relative risk for cancers such as solid cancer, lung cancer, and lymphomas in the radiation group after adjustment for sex, age, year of birth, and year to start working, and stratified analyses on the risks for total cancer and solid cancer in the radiation group were performed for confounders such as sex.</div></div><div><h3>Results</h3><div>The total number of person-years of follow-up was 52,327, and the loss to follow-up rate was 3.15%. A total of 544 cancer cases were detected in follow-up during this period. Compared with the control group, the hazard ratio (<em>HR)</em> of total cancer was 1.13 (95% <em>CI</em>: 0.93–1.37), and the <em>HR</em> of solid cancer was 1.11 (95% <em>CI</em>: 0.91–1.36) in the radiation group. Compared with the control group, the radiation group had significantly higher risk for lymphoma (<em>HR</em> = 10.36, 95% <em>CI</em>:1.27–84.27). Stratified analyses showed that the medical X-ray workers who started to working before 1970 had higher risks for solid cancer (<em>HR</em> = 1.26, 95% <em>CI</em>:1.01–1.59) and total cancer (<em>HR</em> = 1.29, 95% <em>CI</em>:1.04–1.62) compared with those who started working after 1970.</div></div><div><h3>Conclusion</h3><div>The risk for lymphoma was high in the medical X-ray workers in Jiangsu, suggesting that it is necessaryt to strengthen the occupational radiation protection for medical X-ray workers.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 69-74"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.radmp.2025.01.001
Liren Qian, Yu Liu, Xiaoxuan Lu, Jiaxin Liu
Objective
To investigate the therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) on acute radiation injury.
Methods
Irradiated mice were randomly divided into six groups, i.e., the control group, the irradiation group, and groups treated with transplantation at 0, 4, 8, and 12 d post-irradiation, with 10 mice in each group. The survival rates, graft versus host disease (GvHD), and chimerism of the mice in various groups were assessed.
Results
The maximum 60 d survival rate of mice treated with non-preconditioning allo-HSCT at 0, 4, and 8 d after 6.5 Gy radiation increased to 70% and 80%, respectively, significantly higher than that of mice that did not undergo non-preconditioning allo-HSCT (50%; P < 0.05). The survival rate of mice undergoing non-preconditioning allo-HSCT at 12 d after radiation no longer significantly decreased. No pronounced GvHD was observed in the mice. The mice treated with non-preconditioning allo-HSCT at 0, 4, 8, and 12 d post-radiation exhibited chimerism rates of 80.53%, 92.75%, 80.46%, and 80.87%, respectively, at 56 d post-transplantation. At 28 d after non-preconditioning allo-HSCT, the donor-derived fluorescent cells in recipient mice increased significantly (P < 0.05).
Conclusions
This study will fill the gap in the field of radiation medicine and hematopoietic stem cell transplantation (HSCT) by addressing challenges that hinder the application of traditional HSCT, such as donor shortage, toxicity of preconditioning chemotherapy, the occurrence of GvHD, and the administration of post-transplantation immunosuppressants. The results would provide theoretical value and application prospects for research on radiation medicine and HSCT.
{"title":"Therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation on acute radiation injury","authors":"Liren Qian, Yu Liu, Xiaoxuan Lu, Jiaxin Liu","doi":"10.1016/j.radmp.2025.01.001","DOIUrl":"10.1016/j.radmp.2025.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) on acute radiation injury.</div></div><div><h3>Methods</h3><div>Irradiated mice were randomly divided into six groups, i.e., the control group, the irradiation group, and groups treated with transplantation at 0, 4, 8, and 12 d post-irradiation, with 10 mice in each group. The survival rates, graft versus host disease (GvHD), and chimerism of the mice in various groups were assessed.</div></div><div><h3>Results</h3><div>The maximum 60 d survival rate of mice treated with non-preconditioning allo-HSCT at 0, 4, and 8 d after 6.5 Gy radiation increased to 70% and 80%, respectively, significantly higher than that of mice that did not undergo non-preconditioning allo-HSCT (50%; <em>P <</em> 0.05). The survival rate of mice undergoing non-preconditioning allo-HSCT at 12 d after radiation no longer significantly decreased. No pronounced GvHD was observed in the mice. The mice treated with non-preconditioning allo-HSCT at 0, 4, 8, and 12 d post-radiation exhibited chimerism rates of 80.53%, 92.75%, 80.46%, and 80.87%, respectively, at 56 d post-transplantation. At 28 d after non-preconditioning allo-HSCT, the donor-derived fluorescent cells in recipient mice increased significantly (<em>P</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>This study will fill the gap in the field of radiation medicine and hematopoietic stem cell transplantation (HSCT) by addressing challenges that hinder the application of traditional HSCT, such as donor shortage, toxicity of preconditioning chemotherapy, the occurrence of GvHD, and the administration of post-transplantation immunosuppressants. The results would provide theoretical value and application prospects for research on radiation medicine and HSCT.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 103-106"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.radmp.2025.02.003
S. Semghouli , M. El Fahssi , M. Zerfaoui , A. Hadaoui , B. Amaoui
Objective
To explore the perception of Moroccan medical physicists regarding the use of Artificial Intelligent (AI) in medical imaging and in radiotherapy.
Methods
A standardized anonymous questionnaire of 24 questions was sent to our target population, medical physics PhDs (G1), medical physics PhD students (G2) and Master's students in medical physics (G3). It covers their knowledge and skills in artificial intelligence, their training in the field as well as their practices, and the threats and limits of AI.
Results
The three groups shared almost the same opinions on the training program for medical physicists and that more than 87.50% of the three groups thought that AI should be taught in their training program. Over 81.3% of the three groups share the same opinion regarding the role of AI in medical physicists. They strongly agreed or agreed that they were ready to learn and apply AI in their practice. In addition, 50% of G1s, 68.8% of G2s, and 87.5% of G3s strongly agree or agree that more and more tasks, such as quality control and treatment planning, will be performed by AI. Furthermore, 62.5% of G1s, 81.3% of G2s, and 75.0% of G3s strongly agree or agree that AI solutions will make it possible to considerably reduce radiation doses in the field of imaging in the next few years.
Conclusion
The reinforcement of continuous training and the introduction of training modules in the curriculum of Moroccan medical physicists’ as well as a broad awareness of the benefits of AI are guarantees for the successful implementation of this innovative technology.
{"title":"Knowledge and perceptions of Moroccan medical physicists regarding the contribution of artificial intelligence in medical imaging and radiotherapy","authors":"S. Semghouli , M. El Fahssi , M. Zerfaoui , A. Hadaoui , B. Amaoui","doi":"10.1016/j.radmp.2025.02.003","DOIUrl":"10.1016/j.radmp.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the perception of Moroccan medical physicists regarding the use of Artificial Intelligent (AI) in medical imaging and in radiotherapy.</div></div><div><h3>Methods</h3><div>A standardized anonymous questionnaire of 24 questions was sent to our target population, medical physics PhDs (G1), medical physics PhD students (G2) and Master's students in medical physics (G3). It covers their knowledge and skills in artificial intelligence, their training in the field as well as their practices, and the threats and limits of AI.</div></div><div><h3>Results</h3><div>The three groups shared almost the same opinions on the training program for medical physicists and that more than 87.50% of the three groups thought that AI should be taught in their training program. Over 81.3% of the three groups share the same opinion regarding the role of AI in medical physicists. They strongly agreed or agreed that they were ready to learn and apply AI in their practice. In addition, 50% of G1s, 68.8% of G2s, and 87.5% of G3s strongly agree or agree that more and more tasks, such as quality control and treatment planning, will be performed by AI. Furthermore, 62.5% of G1s, 81.3% of G2s, and 75.0% of G3s strongly agree or agree that AI solutions will make it possible to considerably reduce radiation doses in the field of imaging in the next few years.</div></div><div><h3>Conclusion</h3><div>The reinforcement of continuous training and the introduction of training modules in the curriculum of Moroccan medical physicists’ as well as a broad awareness of the benefits of AI are guarantees for the successful implementation of this innovative technology.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 75-80"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.radmp.2024.09.001
Haiying Wang, Weijin Zou, Yi Cao
Bioelectromagnetic signaling, a fundamental aspect of biological systems, has gained increasing attention in recent years. This review synthesizes current knowledge and recent advancements in bioelectromagnetic research, covering principles, evidence, and emerging applications. We discuss the generation, reception, and roles of bioelectromagnetic fields in living organisms, focusing on intercellular and organism-level communication. The review also examines therapeutic applications, and technological innovations arising from our understanding of bioelectromagnetic phenomena. Finally, we outline future research directions that promise to deepen our comprehension of life's electromagnetic dimensions and potentially revolutionize medicine and technology.
{"title":"Bioelectromagnetic fields as signaling currents of life","authors":"Haiying Wang, Weijin Zou, Yi Cao","doi":"10.1016/j.radmp.2024.09.001","DOIUrl":"10.1016/j.radmp.2024.09.001","url":null,"abstract":"<div><div>Bioelectromagnetic signaling, a fundamental aspect of biological systems, has gained increasing attention in recent years. This review synthesizes current knowledge and recent advancements in bioelectromagnetic research, covering principles, evidence, and emerging applications. We discuss the generation, reception, and roles of bioelectromagnetic fields in living organisms, focusing on intercellular and organism-level communication. The review also examines therapeutic applications, and technological innovations arising from our understanding of bioelectromagnetic phenomena. Finally, we outline future research directions that promise to deepen our comprehension of life's electromagnetic dimensions and potentially revolutionize medicine and technology.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 112-118"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the workload management and guarantee the technical concerns for an appropriate radiation protection method in non-destructive testing (NDT) industries in Bangladesh.
Methods
The radiation exposure for 721 workers was investigated in industrial radiography through Bangladesh during 2019–2022. A thermoluminescence dosimeter (TLD-100) was used to measure the occupational exposure with the operational dose quantity Hp(10). All the readout procedures were completed using the Harshaw TLD reader (model 4500).
Results
The collective effective dose was 75.73, 115.35, 150.18, and 96 mSv in year 2019, 2020, 2021, and 2022, respectively. The maximum effective dose received among the workers was 19.45, 3.8, 19.19, and 19.53 mSv, respectively, which remained within the stipulated dose limits imposed by Nuclear Safety and Radiation Control (NSRC) Rules-1997, Bangladesh and International Commission on Radiological Protection (ICRP-103). The mean annual individual dose was 0.53, 0.8, 0.83, and 0.39 mSv in 2019, 2020, 2021, and 2022, respectively. The mean value of excess life-time cancer risk (ELCR) was found 1.12 × 10−3.
Conclusion
The industrial radiography facilities of Bangladesh may be certain that their current safety protocols are adequate. Additionally, few recommendations for safe industrial radiography practices have also been offered.
{"title":"Occupational radiation exposure analysis in industrial radiography in Bangladesh","authors":"Mehedi Hassan, Shahadat Hossain, M.M. Mahfuz Siraz, Shikha Pervin, Nazneen Sultana, Md Zakir Hossain, Selina Yeasmin","doi":"10.1016/j.radmp.2025.03.002","DOIUrl":"10.1016/j.radmp.2025.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the workload management and guarantee the technical concerns for an appropriate radiation protection method in non-destructive testing (NDT) industries in Bangladesh.</div></div><div><h3>Methods</h3><div>The radiation exposure for 721 workers was investigated in industrial radiography through Bangladesh during 2019–2022. A thermoluminescence dosimeter (TLD-100) was used to measure the occupational exposure with the operational dose quantity <em>H</em><sub>p</sub>(10). All the readout procedures were completed using the Harshaw TLD reader (model 4500).</div></div><div><h3>Results</h3><div>The collective effective dose was 75.73, 115.35, 150.18, and 96 mSv in year 2019, 2020, 2021, and 2022, respectively. The maximum effective dose received among the workers was 19.45, 3.8, 19.19, and 19.53 mSv, respectively, which remained within the stipulated dose limits imposed by Nuclear Safety and Radiation Control (NSRC) Rules-1997, Bangladesh and International Commission on Radiological Protection (ICRP-103). The mean annual individual dose was 0.53, 0.8, 0.83, and 0.39 mSv in 2019, 2020, 2021, and 2022, respectively. The mean value of excess life-time cancer risk (ELCR) was found 1.12 × 10<sup>−3</sup>.</div></div><div><h3>Conclusion</h3><div>The industrial radiography facilities of Bangladesh may be certain that their current safety protocols are adequate. Additionally, few recommendations for safe industrial radiography practices have also been offered.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 107-111"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.radmp.2025.02.001
Jialing Wen , Xiangdi Meng , Wenchao Gu , Shenke Zhang , Li Sui , Gang Guo , Liang Yan , Wangcai Ren , Xuanzhang Tu , Kensuke Osada , Takashi Shimokawa , Yang Li , Liqiu Ma
Objective
To compare the efficacy and toxicity of four treatment strategies in patients with MBMs.
Methods
A systematic literature search of the Cochrane, PubMed, Embase, Web of Science, and OVID Medline databases was performed until July 24, 2024. A total of four therapeutic modalities for MBMs, including immune checkpoint inhibitor (ICI) monotherapy, radiotherapy (RT) alone, ICI combined with RT (ICI + RT), and dual ICI therapy (ICI + ICI), were evaluated by the overall survival (OS), intracranial progression-free survival (iPFS), and adverse effect (AE). The meta-analysis was performed using R language and registered in PROSPERO (registration no. CRD42023480912).
Results
This study included 33 studies comprising 2,496 patients with MBMs. ICI combined with RT and dual ICI therapy improved the 6 and 12-month OS rates compared with ICI monotherapy and RT alone. There was no significant difference in OS between the ICI + RT group and the ICI + ICI group. Similar results were observed for iPFS, with the combination treatment groups showing a significant difference compared with the treatment groups alone. However, no significant difference was observed in 1-year iPFS between the ICI + RT group and the ICI + ICI group (P = 0.07), whereas the ICI + ICI group demonstrated superior 2-year iPFS compared with the ICI + RT group (P < 0.05). Furthermore, the survival advantages of combination therapy gradually decreased with increasing duration of treatment. Additionally, compared with ICI monotherapy, dual ICI therapy significantly increased the incidence of AEs over grade 3 (ICI + ICI: 57% vs. ICI: 11%, P < 0.0001), whereas ICI combined with RT did not significantly differ (ICI + RT: 19% vs. ICI: 11%, P = 0.14).
Conclusion
The combination of ICI with RT offers superior survival benefits without increasing toxicity in patients with MBMs. However, this survival benefit decreases over time, and further optimizing the treatment strategy is essential for improving the outcomes of patients with MBMs.
目的比较四种治疗方案对骨髓瘤的疗效和毒副作用。方法系统检索Cochrane、PubMed、Embase、Web of Science、OVID Medline数据库，检索时间截止到2024年7月24日。通过总生存期（OS）、颅内无进展生存期（iPFS）和不良反应（AE）评估四种治疗方式，包括免疫检查点抑制剂（ICI）单药治疗、单独放疗（RT）、ICI联合放疗（ICI + RT）和双重ICI治疗（ICI + ICI）。meta分析使用R语言进行，并在PROSPERO注册(注册号：CRD42023480912)。结果本研究纳入33项研究，包括2496例MBMs患者。与ICI单药治疗和单独RT相比，ICI联合RT和双ICI治疗提高了6个月和12个月的OS率。ICI + RT组与ICI + ICI组的OS无显著差异。iPFS也观察到类似的结果，联合治疗组与单独治疗组相比有显著差异。然而，ICI + RT组和ICI + ICI组的1年iPFS没有显著差异（P = 0.07），而ICI + ICI组的2年iPFS优于ICI + RT组(P <；0.05)。此外，联合治疗的生存优势随着治疗时间的增加而逐渐降低。此外，与ICI单药治疗相比，双重ICI治疗显著增加了3级以上ae的发生率(ICI + ICI: 57% vs. ICI: 11%, P <；0.0001)，而ICI联合RT无显著差异（ICI + RT: 19% vs ICI: 11%, P = 0.14）。结论：在不增加毒性的情况下，ICI联合RT治疗对MBMs患者有更好的生存益处。然而，这种生存益处随着时间的推移而减少，进一步优化治疗策略对于改善MBMs患者的预后至关重要。
{"title":"Survival benefits and toxicity effects of radiotherapy and immunotherapy treatments in melanoma patients with brain metastases: A meta-analysis","authors":"Jialing Wen , Xiangdi Meng , Wenchao Gu , Shenke Zhang , Li Sui , Gang Guo , Liang Yan , Wangcai Ren , Xuanzhang Tu , Kensuke Osada , Takashi Shimokawa , Yang Li , Liqiu Ma","doi":"10.1016/j.radmp.2025.02.001","DOIUrl":"10.1016/j.radmp.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the efficacy and toxicity of four treatment strategies in patients with MBMs.</div></div><div><h3>Methods</h3><div>A systematic literature search of the Cochrane, PubMed, Embase, Web of Science, and OVID Medline databases was performed until July 24, 2024. A total of four therapeutic modalities for MBMs, including immune checkpoint inhibitor (ICI) monotherapy, radiotherapy (RT) alone, ICI combined with RT (ICI + RT), and dual ICI therapy (ICI + ICI), were evaluated by the overall survival (OS), intracranial progression-free survival (iPFS), and adverse effect (AE). The meta-analysis was performed using R language and registered in PROSPERO (registration no. CRD42023480912).</div></div><div><h3>Results</h3><div>This study included 33 studies comprising 2,496 patients with MBMs. ICI combined with RT and dual ICI therapy improved the 6 and 12-month OS rates compared with ICI monotherapy and RT alone. There was no significant difference in OS between the ICI + RT group and the ICI + ICI group. Similar results were observed for iPFS, with the combination treatment groups showing a significant difference compared with the treatment groups alone. However, no significant difference was observed in 1-year iPFS between the ICI + RT group and the ICI + ICI group (<em>P</em> = 0.07), whereas the ICI + ICI group demonstrated superior 2-year iPFS compared with the ICI + RT group (<em>P</em> < 0.05). Furthermore, the survival advantages of combination therapy gradually decreased with increasing duration of treatment. Additionally, compared with ICI monotherapy, dual ICI therapy significantly increased the incidence of AEs over grade 3 (ICI + ICI: 57% <em>vs.</em> ICI: 11%, <em>P</em> < 0.0001), whereas ICI combined with RT did not significantly differ (ICI + RT: 19% <em>vs.</em> ICI: 11%, <em>P</em> = 0.14).</div></div><div><h3>Conclusion</h3><div>The combination of ICI with RT offers superior survival benefits without increasing toxicity in patients with MBMs. However, this survival benefit decreases over time, and further optimizing the treatment strategy is essential for improving the outcomes of patients with MBMs.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 91-102"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号