Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-209-214
I. I. Grishin, T. G. Chirvon, O.R. Oguede
Polycystic ovary syndrome (PCOS) is a common endocrine disorder and one of the main causes of anovulation in women of childbearing age. Surgical procedures for infertility treatment in women with PCOS have been used in clinical practice for a long time. As a rule, they are considered as a second-line therapy after the first-line pharmacological treatment. Since recently the focus has shifted to the comparison of different types of surgical treatment techniques, their effects on the ovarian function, and the development of adhesions. The article reviews the most common surgical options for PCOS treatment in various patient groups and the key results obtained in the top importance studies undertaken in this area. Surgical treatment of PCOS in properly selected patients seems to be a cost-effective therapeutic option that has comparable success rates to ovulation induction with gonadotropins. Laparoscopic ovarian drilling is one of the preferable minimally invasive techniques. This procedure is recommended for patients who have other indications for laparoscopy, or if there is a high risk of ovarian hyperstimulation syndrome and multiple pregnancy, or if there are contraindications to multiple pregnancy. At the same time, it is emphasized that the uniform regimens and standards of PCOS surgical treatment have not been optimized so far. Their outcomes are understudied and the issue is still open for discussion. KEYWORDS: laparoscopic ovarian drilling, polycystic ovary syndrome, ovarian hyperstimulation syndrome, anovulation, infertility, adhesions. FOR CITATION: Grishin I.I., Chirvon T.G., Oguede O.R. Current trends in surgical treatment for infertility associated with polycystic ovary syndrome. Russian Journal of Woman and Child Health. 2022;5(3):209–214 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-209-214.
{"title":"Current trends in surgical treatment for infertility associated with polycystic ovary syndrome","authors":"I. I. Grishin, T. G. Chirvon, O.R. Oguede","doi":"10.32364/2618-8430-2022-5-3-209-214","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-209-214","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a common endocrine disorder and one of the main causes of anovulation in women of childbearing age. Surgical procedures for infertility treatment in women with PCOS have been used in clinical practice for a long time. As a rule, they are considered as a second-line therapy after the first-line pharmacological treatment. Since recently the focus has shifted to the comparison of different types of surgical treatment techniques, their effects on the ovarian function, and the development of adhesions. The article reviews the most common surgical options for PCOS treatment in various patient groups and the key results obtained in the top importance studies undertaken in this area. Surgical treatment of PCOS in properly selected patients seems to be a cost-effective therapeutic option that has comparable success rates to ovulation induction with gonadotropins. Laparoscopic ovarian drilling is one of the preferable minimally invasive techniques. This procedure is recommended for patients who have other indications for laparoscopy, or if there is a high risk of ovarian hyperstimulation syndrome and multiple pregnancy, or if there are contraindications to multiple pregnancy. At the same time, it is emphasized that the uniform regimens and standards of PCOS surgical treatment have not been optimized so far. Their outcomes are understudied and the issue is still open for discussion. KEYWORDS: laparoscopic ovarian drilling, polycystic ovary syndrome, ovarian hyperstimulation syndrome, anovulation, infertility, adhesions. FOR CITATION: Grishin I.I., Chirvon T.G., Oguede O.R. Current trends in surgical treatment for infertility associated with polycystic ovary syndrome. Russian Journal of Woman and Child Health. 2022;5(3):209–214 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-209-214.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-28-34
P. Kuznetsov, L. Dzhokhadze, V.V. Shamugiya, O. Kravtsova, Y. Dobrokhotova
This paper reviews current published data on the use of acetylsalicylic acid (ASA) for preventing preeclampsia and its complications and techniques to determine risk groups for im-plementing this preventive treatment. In addition, the authors summarize data on the history of ASA advent and introduction into medical practice (particularly obstetrics) and presumed mech-anisms of its action as first-line therapy to prevent preeclampsia. Recent review papers and guidelines addressing optimal ASA dose, treatment duration, and dosing during pregnancy in Russia and worldwide are discussed. Methods that have been studied as preventive ones for preeclampsia are briefly discussed. It was demonstrated that anamnestic determination of risk groups of early preeclampsia is not always enough. Expanded combined first-trimester screening is a perspective diagnostic tool. Success in determining high-risk groups and optimal prevention of preeclampsia may significantly affect population health by reducing maternal and perinatal mortality and long-term risk of cardiovascular events both in the mother and child. KEYWORDS: preeclampsia, acetylsalicylic acid, screening, placental disorders, trophoblast, fetal growth restriction, prevention of preeclampsia, uterine artery pulsatility index, pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PlGF). FOR CITATION: Kuznetsov P.A., Dzhokhadze L.S., Shamugiya V.V., Kravtsova O.M. Acetylsalicylic acid to prevent preeclampsia and its complications. State-of-the-art of risk groups. Russian Journal of Woman and Child Health. 2022;5(1):28–34 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-28-34.
{"title":"Acetylsalicylic acid to prevent preeclampsia and its complications. State-of-the-art of risk groups","authors":"P. Kuznetsov, L. Dzhokhadze, V.V. Shamugiya, O. Kravtsova, Y. Dobrokhotova","doi":"10.32364/2618-8430-2022-5-1-28-34","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-28-34","url":null,"abstract":"This paper reviews current published data on the use of acetylsalicylic acid (ASA) for preventing preeclampsia and its complications and techniques to determine risk groups for im-plementing this preventive treatment. In addition, the authors summarize data on the history of ASA advent and introduction into medical practice (particularly obstetrics) and presumed mech-anisms of its action as first-line therapy to prevent preeclampsia. Recent review papers and guidelines addressing optimal ASA dose, treatment duration, and dosing during pregnancy in Russia and worldwide are discussed. Methods that have been studied as preventive ones for preeclampsia are briefly discussed. It was demonstrated that anamnestic determination of risk groups of early preeclampsia is not always enough. Expanded combined first-trimester screening is a perspective diagnostic tool. Success in determining high-risk groups and optimal prevention of preeclampsia may significantly affect population health by reducing maternal and perinatal mortality and long-term risk of cardiovascular events both in the mother and child. KEYWORDS: preeclampsia, acetylsalicylic acid, screening, placental disorders, trophoblast, fetal growth restriction, prevention of preeclampsia, uterine artery pulsatility index, pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PlGF). FOR CITATION: Kuznetsov P.A., Dzhokhadze L.S., Shamugiya V.V., Kravtsova O.M. Acetylsalicylic acid to prevent preeclampsia and its complications. State-of-the-art of risk groups. Russian Journal of Woman and Child Health. 2022;5(1):28–34 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-28-34.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69548175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-58-62
I. Sergeeva
Aim: to assess the efficacy of the composition of natural essential oils (inhaler patch) for the prevention and complex treatment of acute respiratory infections (ARIs) in pre-school children. Patients and Methods: this prospective study enrolled 102 children aged 3–7 attending kindergarten. The study was conducted simultaneously in four groups of children attending pre-schools (study and control groups, respectively). Study group children received passive inhalations of essential oils (inhaler patches), i.e., in combination with complex treatment for ARIs (group 1) or as a preventive measure after contact with sick children (group 3). Control group children (groups 2 and 4) did not receive passive inhalations. The rate of ARIs, disease severity, fever duration, catarrhal period duration, and inhaler patch tolerability were assessed. Results: in children who used inhaler patch to prevent ARI but still got sick (group 3), fever duration was 1.5 days (i.e., 2.3 days shorter than in group 4) irrespective of age. The number of sick children in group 3 was 2.2-times lower than in group 4. The disease was mild, not associated with any complications, and characterized by a shorter duration of the catarrhal period. In group 1 (compared to group 2), body temperature was less than 38°C, and more rapid rhinorrhea, nasal congestion, and cough relief were reported. Conclusions: our findings, in combination with the lack of adverse effects, allow us to recommend an inhaler patch to prevent ARIs during epidemics or seasonal peaks in pre-schools as a highly adherent entity characterized by excellent safety, no addiction, and long-term use. KEYWORDS: prevention, ARIs, essential oils, children, efficacy, inhaler patch. FOR CITATION: Sergeeva I.V. Highly adherent essential oils compositions for the prevention and complex treatment of ARIs in pre-school children. Russian Journal of Woman and Child Health. 2022;5(1):58–62 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-58-62.
{"title":"Highly adherent essential oils compositions for the prevention and complex treatment of ARIs in pre-school children","authors":"I. Sergeeva","doi":"10.32364/2618-8430-2022-5-1-58-62","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-58-62","url":null,"abstract":"Aim: to assess the efficacy of the composition of natural essential oils (inhaler patch) for the prevention and complex treatment of acute respiratory infections (ARIs) in pre-school children. Patients and Methods: this prospective study enrolled 102 children aged 3–7 attending kindergarten. The study was conducted simultaneously in four groups of children attending pre-schools (study and control groups, respectively). Study group children received passive inhalations of essential oils (inhaler patches), i.e., in combination with complex treatment for ARIs (group 1) or as a preventive measure after contact with sick children (group 3). Control group children (groups 2 and 4) did not receive passive inhalations. The rate of ARIs, disease severity, fever duration, catarrhal period duration, and inhaler patch tolerability were assessed. Results: in children who used inhaler patch to prevent ARI but still got sick (group 3), fever duration was 1.5 days (i.e., 2.3 days shorter than in group 4) irrespective of age. The number of sick children in group 3 was 2.2-times lower than in group 4. The disease was mild, not associated with any complications, and characterized by a shorter duration of the catarrhal period. In group 1 (compared to group 2), body temperature was less than 38°C, and more rapid rhinorrhea, nasal congestion, and cough relief were reported. Conclusions: our findings, in combination with the lack of adverse effects, allow us to recommend an inhaler patch to prevent ARIs during epidemics or seasonal peaks in pre-schools as a highly adherent entity characterized by excellent safety, no addiction, and long-term use. KEYWORDS: prevention, ARIs, essential oils, children, efficacy, inhaler patch. FOR CITATION: Sergeeva I.V. Highly adherent essential oils compositions for the prevention and complex treatment of ARIs in pre-school children. Russian Journal of Woman and Child Health. 2022;5(1):58–62 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-58-62.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69548768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-106-111
Y. Dobrokhotova, E. Borovkova, V. Romanovskaya, I.V. Stepanyants
Aim: to assess long-term outcomes of exogenous cytokine therapy in pregnant women with cervical intraepithelial neoplasia (CIN). Patients and Methods: this prospective study included 50 pregnant women with CIN. Women were randomized into two groups. Group 1 women (n=30, mean age 31.6±1.7 years) received vaginal suppositories with Superlymph 25 U. Group 2 women (n=20, mean age 29.8±1.4 years) received rectal suppositories with Superlymph 25 U. Cervical smear cytology (at baseline, 22 days after starting treatment, and 6 weeks after delivery), colposcopy, and cervical biopsy (at baseline and 6 weeks after delivery) were performed. Results: in group 1, cytology revealed high-grade squamous intraepithelial lesion (HSIL) in 43.3%, atypical squamous cells-cannot exclude a high-grade lesion (ASC-H) in 6.7%, and atypical squamous cells of undetermined significance (ASCUS) in 10%. In group 2, cytology revealed low-grade squamous intraepithelial lesion (LSIL) in 25%, HSIL in 45%, ASC-H in 10%, and ASCUS in 20%. After the treatment course, in group 1, a regress from HSIL to LSIL was detected in 6.7%, regress from LSIL to ASCUS in 3.3%, and regress from HSIL to ASC-H in 3.3%. In group 2, NILM was detected in 5%, a regress from HSIL to LSIL in 5%, and regress from LSIL to ASCUS in 5%. Histologically, LSIL was verified in 50% of women of both groups, CIN grade 2 in 36.7% (group 1) and 40% (group 2), CIN grade 3 in 13.3% (group 1) and 10% (group 2). Six weeks after delivery, cytological abnormalities were identified in 30 women of both groups (HSIL in 56.7% and LSIL in 43.3%). Histology detected carcinoma in situ in 3.3% and CIN grade 2–3 in 53.3%. Delivery in time (on average, at 38.4±1.1 weeks of gestation) occurred in all women. Conclusion: trend toward the improvement of cytological parameters irrespective of the mode of drug administration is reported after finishing cytokine therapy. Normalization of cytological findings was reported in 3.3% (group 1) and 5% (group 2), while improvement was reported in 6.6% (group 1) and 10% (group 2). No worsening was reported.
{"title":"Long-term outcomes of cytokine therapy in pregnant women with cervical intraepithelial neoplasia","authors":"Y. Dobrokhotova, E. Borovkova, V. Romanovskaya, I.V. Stepanyants","doi":"10.32364/2618-8430-2022-5-2-106-111","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-106-111","url":null,"abstract":"Aim: to assess long-term outcomes of exogenous cytokine therapy in pregnant women with cervical intraepithelial neoplasia (CIN). Patients and Methods: this prospective study included 50 pregnant women with CIN. Women were randomized into two groups. Group 1 women (n=30, mean age 31.6±1.7 years) received vaginal suppositories with Superlymph 25 U. Group 2 women (n=20, mean age 29.8±1.4 years) received rectal suppositories with Superlymph 25 U. Cervical smear cytology (at baseline, 22 days after starting treatment, and 6 weeks after delivery), colposcopy, and cervical biopsy (at baseline and 6 weeks after delivery) were performed. Results: in group 1, cytology revealed high-grade squamous intraepithelial lesion (HSIL) in 43.3%, atypical squamous cells-cannot exclude a high-grade lesion (ASC-H) in 6.7%, and atypical squamous cells of undetermined significance (ASCUS) in 10%. In group 2, cytology revealed low-grade squamous intraepithelial lesion (LSIL) in 25%, HSIL in 45%, ASC-H in 10%, and ASCUS in 20%. After the treatment course, in group 1, a regress from HSIL to LSIL was detected in 6.7%, regress from LSIL to ASCUS in 3.3%, and regress from HSIL to ASC-H in 3.3%. In group 2, NILM was detected in 5%, a regress from HSIL to LSIL in 5%, and regress from LSIL to ASCUS in 5%. Histologically, LSIL was verified in 50% of women of both groups, CIN grade 2 in 36.7% (group 1) and 40% (group 2), CIN grade 3 in 13.3% (group 1) and 10% (group 2). Six weeks after delivery, cytological abnormalities were identified in 30 women of both groups (HSIL in 56.7% and LSIL in 43.3%). Histology detected carcinoma in situ in 3.3% and CIN grade 2–3 in 53.3%. Delivery in time (on average, at 38.4±1.1 weeks of gestation) occurred in all women. Conclusion: trend toward the improvement of cytological parameters irrespective of the mode of drug administration is reported after finishing cytokine therapy. Normalization of cytological findings was reported in 3.3% (group 1) and 5% (group 2), while improvement was reported in 6.6% (group 1) and 10% (group 2). No worsening was reported.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-153-156
S. B. Kerchelaeva, V.V. Dergunova, N. Ivannikov, O. Yushina
Extragenital diseases currently hold one of the leading positions among the causes of maternal death. Brain arteriovenous malformation (AVM) is a congenital anomaly of the vascular system, which is a pathological direct connection between small arteries and small veins without an interim capillary network. This phenomenon is a prerequisite for vessel rupture and hemorrhage that is potentially lethal or results in severe disability. Brain AVMs cause intracranial hemorrhages in 23% of pregnant women and maternal death in 5–12%. The authors share their experience with brain AVM in a pregnant woman with favorable maternal and fetal outcomes. Management approaches are discussed. Timely diagnosis of AVM during pregnancy, multimodal management approach to pregnancy, delivery, and postnatal period, and the development of medical care algorithm reduce the rate of maternal death and morbidity and improve perinatal outcomes. KEYWORDS: pregnancy, delivery, postnatal period, arteriovenous malformation, hemorrhage, multimodal approach. FOR CITATION: Kerchelaeva S.B., Dergunova V.V., Ivannikov N.Yu., Yushina O.Yu. Multimodal approach to the management of pregnant women with brain arteriovenous malformation. Russian Journal of Woman and Child Health. 2022;5(2):153–156 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-153-156
{"title":"Multimodal approach to the management of pregnant women with brain arteriovenous malformation","authors":"S. B. Kerchelaeva, V.V. Dergunova, N. Ivannikov, O. Yushina","doi":"10.32364/2618-8430-2022-5-2-153-156","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-153-156","url":null,"abstract":"Extragenital diseases currently hold one of the leading positions among the causes of maternal death. Brain arteriovenous malformation (AVM) is a congenital anomaly of the vascular system, which is a pathological direct connection between small arteries and small veins without an interim capillary network. This phenomenon is a prerequisite for vessel rupture and hemorrhage that is potentially lethal or results in severe disability. Brain AVMs cause intracranial hemorrhages in 23% of pregnant women and maternal death in 5–12%. The authors share their experience with brain AVM in a pregnant woman with favorable maternal and fetal outcomes. Management approaches are discussed. Timely diagnosis of AVM during pregnancy, multimodal management approach to pregnancy, delivery, and postnatal period, and the development of medical care algorithm reduce the rate of maternal death and morbidity and improve perinatal outcomes. KEYWORDS: pregnancy, delivery, postnatal period, arteriovenous malformation, hemorrhage, multimodal approach. FOR CITATION: Kerchelaeva S.B., Dergunova V.V., Ivannikov N.Yu., Yushina O.Yu. Multimodal approach to the management of pregnant women with brain arteriovenous malformation. Russian Journal of Woman and Child Health. 2022;5(2):153–156 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-153-156","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-223-227
E. O. Boyko, Y. Vasyanina, Yu.A. Mylnikova, E.K. Aleksanyan
Background: according to the World Health Organization (WHO), every year about 700,000 people die as a result of suicide. In the age group of 15–19 years, suicide is the fourth leading cause of death. In 2011 UNICEF released the report based on the Federal Service for State Statistics (Rosstat) data, according to which every twelfth teenager aged 13–17 years is trying to commit suicide in Russia. Aim: to study the frequency and case structure of suicidal activity in children and adolescents in the Krasnodar Territory for further improvement of measures to reduce the risk of autoaggressive behavior. Patients and Methods: the article presents the analysis of indicators concerning suicidal activity in children and adolescents of the Krasnodar Territory for the period 2020–2021. The data were obtained from specialists of the psychiatric and pediatric service of the Krasnodar Territory, the Directorate of the Federal Service for State Statistics of the Krasnodar Territory and the Republic of Adygea (Krasnodarstat), and the Directorate for Registry Offices of the Krasnodar Territory with the support of Medical Information and Analytical Center. Results: in 2020, 98 cases of autoaggressive behavior were registered. Of these, 70 (71.4%) cases of incomplete suicide attempts, 25 (25.5%) cases of suicidal statements and 3 (3.1%) completed suicides. In 2021, there were 138 cases of suicidal behavior of minor residents registered in the Krasnodar Territory, of which 91 (65.9%) cases of incomplete suicide attempts, 40 (29%) cases of suicidal statements, intentions and threats without committing a suicide attempt, and 7 (5.1%) cases of completed suicides. In the contingent of persons with incomplete suicidal attempts (90 minors), there was a significant predominance of females 79 (85.9%) and 75 (83.3%) people in 2020 and 2021, respectively, as well as the predominance of the age group of 15–17 years old 48 (69.6%) and 68 (75.6%) people in 2020 and 2021, respectively. In the structure of the methods concerning committing incomplete suicidal attempts, the administration of medications and other substances, as well as self-harm, were most commonly recorded. Conclusion: incomplete suicide attempts and the number of suicide deaths among children and adolescents of the Krasnodar Territory were analyzed by age and sex. The main ways of implementing auto-aggressive behavior, representation in various regions of the Krasnodar Territory, as well as the measures conducted by outpatient and inpatient psychiatric services in order to prevent suicidal behavior in the study cohort were identified. KEYWORDS: suicidal activity, autoaggressive activity, completed suicide, suicidal attempt, children, adolescents. FOR CITATION: Boyko E.O., Vasyanina Yu.Sh., Mylnikova Yu.A., Aleksanyan E.K. Prevalence of suicidal behavior in children and adolescents of the Krasnodar Territory. Russian Journal of Woman and Child Health. 2022;5(3):223–227 (in Russ.). DOI: 10.32364/2618- 8430-2022-5-3
{"title":"Prevalence of suicidal behavior in children and adolescents of the Krasnodar Territory","authors":"E. O. Boyko, Y. Vasyanina, Yu.A. Mylnikova, E.K. Aleksanyan","doi":"10.32364/2618-8430-2022-5-3-223-227","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-223-227","url":null,"abstract":"Background: according to the World Health Organization (WHO), every year about 700,000 people die as a result of suicide. In the age group of 15–19 years, suicide is the fourth leading cause of death. In 2011 UNICEF released the report based on the Federal Service for State Statistics (Rosstat) data, according to which every twelfth teenager aged 13–17 years is trying to commit suicide in Russia. Aim: to study the frequency and case structure of suicidal activity in children and adolescents in the Krasnodar Territory for further improvement of measures to reduce the risk of autoaggressive behavior. Patients and Methods: the article presents the analysis of indicators concerning suicidal activity in children and adolescents of the Krasnodar Territory for the period 2020–2021. The data were obtained from specialists of the psychiatric and pediatric service of the Krasnodar Territory, the Directorate of the Federal Service for State Statistics of the Krasnodar Territory and the Republic of Adygea (Krasnodarstat), and the Directorate for Registry Offices of the Krasnodar Territory with the support of Medical Information and Analytical Center. Results: in 2020, 98 cases of autoaggressive behavior were registered. Of these, 70 (71.4%) cases of incomplete suicide attempts, 25 (25.5%) cases of suicidal statements and 3 (3.1%) completed suicides. In 2021, there were 138 cases of suicidal behavior of minor residents registered in the Krasnodar Territory, of which 91 (65.9%) cases of incomplete suicide attempts, 40 (29%) cases of suicidal statements, intentions and threats without committing a suicide attempt, and 7 (5.1%) cases of completed suicides. In the contingent of persons with incomplete suicidal attempts (90 minors), there was a significant predominance of females 79 (85.9%) and 75 (83.3%) people in 2020 and 2021, respectively, as well as the predominance of the age group of 15–17 years old 48 (69.6%) and 68 (75.6%) people in 2020 and 2021, respectively. In the structure of the methods concerning committing incomplete suicidal attempts, the administration of medications and other substances, as well as self-harm, were most commonly recorded. Conclusion: incomplete suicide attempts and the number of suicide deaths among children and adolescents of the Krasnodar Territory were analyzed by age and sex. The main ways of implementing auto-aggressive behavior, representation in various regions of the Krasnodar Territory, as well as the measures conducted by outpatient and inpatient psychiatric services in order to prevent suicidal behavior in the study cohort were identified. KEYWORDS: suicidal activity, autoaggressive activity, completed suicide, suicidal attempt, children, adolescents. FOR CITATION: Boyko E.O., Vasyanina Yu.Sh., Mylnikova Yu.A., Aleksanyan E.K. Prevalence of suicidal behavior in children and adolescents of the Krasnodar Territory. Russian Journal of Woman and Child Health. 2022;5(3):223–227 (in Russ.). DOI: 10.32364/2618- 8430-2022-5-3","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-228-236
E. Radtsig, A. V. Gurov
The article presents a brief review of the current issues relating to the treatment of acute infectious inflammatory diseases associated with sore throat. Painful throat is one of the most common reasons for the administration of systemic antibacterial drugs as a baseline therapy which, in turn, may facilitate a rise in antibiotic resistance. Recently the focus has shifted to the antibacterial therapy impact on the qualitative and quantitative composition of the microbiota. The review elucidates the opportunities of successful etiotropic therapy amid a low risk of the antibiotic resistance development and a lack of the adverse effects on the oropharyngeal microbiota. Updated information is provided characterizing the pharmacological activity of a bacterium-produced non-ribosomal antimicrobial peptide Gramicidin S and Cetylpyridinium chloride, an antiseptic agent. The highest potency of topical medications can be achieved due to the combined action of multiple synergistic components. A potential combined use of Gramicidin S and Cetylpyridinium chloride is discussed in the review from the standpoint of the risk of antibiotic resistance and the impact on microbiota. The authors conclude that for the treatment of infectious inflammatory diseases of the upper respiratory tract associated with sore throat it is advisable to select biocenosis-saving topical etiotropic therapy. KEYWORDS: Gramicidin S, non-ribosomal antimicrobial peptides, Cetylpyridinium chloride, topical etiotropic therapy, bactericidal activity, antibiotic resistance, microbiocenosis-saving therapy, pharyngitis, tonsillopharyngitis. FOR CITATION: Radtsig E.Yu., Gurov A.V. Sore throat. Crossing problems and finding solutions. Russian Journal of Woman and Child Health. 2022;5(3):228–236 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-228-236.
{"title":"Sore throat. Crossing problems and finding solutions","authors":"E. Radtsig, A. V. Gurov","doi":"10.32364/2618-8430-2022-5-3-228-236","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-228-236","url":null,"abstract":"The article presents a brief review of the current issues relating to the treatment of acute infectious inflammatory diseases associated with sore throat. Painful throat is one of the most common reasons for the administration of systemic antibacterial drugs as a baseline therapy which, in turn, may facilitate a rise in antibiotic resistance. Recently the focus has shifted to the antibacterial therapy impact on the qualitative and quantitative composition of the microbiota. The review elucidates the opportunities of successful etiotropic therapy amid a low risk of the antibiotic resistance development and a lack of the adverse effects on the oropharyngeal microbiota. Updated information is provided characterizing the pharmacological activity of a bacterium-produced non-ribosomal antimicrobial peptide Gramicidin S and Cetylpyridinium chloride, an antiseptic agent. The highest potency of topical medications can be achieved due to the combined action of multiple synergistic components. A potential combined use of Gramicidin S and Cetylpyridinium chloride is discussed in the review from the standpoint of the risk of antibiotic resistance and the impact on microbiota. The authors conclude that for the treatment of infectious inflammatory diseases of the upper respiratory tract associated with sore throat it is advisable to select biocenosis-saving topical etiotropic therapy. KEYWORDS: Gramicidin S, non-ribosomal antimicrobial peptides, Cetylpyridinium chloride, topical etiotropic therapy, bactericidal activity, antibiotic resistance, microbiocenosis-saving therapy, pharyngitis, tonsillopharyngitis. FOR CITATION: Radtsig E.Yu., Gurov A.V. Sore throat. Crossing problems and finding solutions. Russian Journal of Woman and Child Health. 2022;5(3):228–236 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-228-236.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-303-308
G. Minkina, K. R. Bondarenko, M. Selikhova, P. Soltys
One of the promising options for reducing the prevalence of inflammatory diseases of the genital organs and preventing their recurrence is to achieve and maintain a normal vaginal microbiome as the first line of natural protection against infections. Medications comprising antibacterial and/or antifungal agents which are widely used in the treatment of abnormal vaginal discharges may cause a substantial decrease in woman’s own lactobacilli. Over the last decade, researchers have focused on probiotics which increase the efficacy of treatment and reduce the rate of disease recurrences. As known, the human gut microbiota plays a central role in the development of healthy microbiome of its host and biotopes of various locations. Thus, the currently preferred oral probiotics include combination products for oral intake which contain multiple symbiont bacterial strains and prebiotic components An oral probiotic comprising a combination of two lactic acid bacteria with synergistic effect, Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 that remain viable after passing through the gastrointestinal tract and maintain ability to colonize the vagina as well as other organs and are characterized by a high level of adhesion to vaginal epithelial cells, helps to increase the lactobacilli count, normalizing microbiome in the woman’s vagina. The recent clinical trials have demonstrated the efficacy of oral administration of the combination of two strains of lactic acid bacteria, L. rhamnosus HN001 and L. acidophilus La-14, in the prevention of recurrences of bacterial vaginosis and vulvovaginal candidiasis with the aim of maintaining and normalizing vaginal microbiome; this combination is approved for taking during pregnancy and breastfeeding. KEYWORDS: vaginal infections, microbiome, probiotics, oral intake, symbiont bacterial strains, normal vaginal biocenosis. FOR CITATION: Minkina G.N., Bondarenko K.R., Selikhova M.S., Soltys P.A. Renaissance of the vaginal microbiota: reframing clinical paradigms. Russian Journal of Woman and Child Health. 2022;5(4):303–308 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-303-308.
{"title":"Renaissance of the vaginal microbiota: reframing clinical paradigms","authors":"G. Minkina, K. R. Bondarenko, M. Selikhova, P. Soltys","doi":"10.32364/2618-8430-2022-5-4-303-308","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-303-308","url":null,"abstract":"One of the promising options for reducing the prevalence of inflammatory diseases of the genital organs and preventing their recurrence is to achieve and maintain a normal vaginal microbiome as the first line of natural protection against infections. Medications comprising antibacterial and/or antifungal agents which are widely used in the treatment of abnormal vaginal discharges may cause a substantial decrease in woman’s own lactobacilli. Over the last decade, researchers have focused on probiotics which increase the efficacy of treatment and reduce the rate of disease recurrences. As known, the human gut microbiota plays a central role in the development of healthy microbiome of its host and biotopes of various locations. Thus, the currently preferred oral probiotics include combination products for oral intake which contain multiple symbiont bacterial strains and prebiotic components An oral probiotic comprising a combination of two lactic acid bacteria with synergistic effect, Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 that remain viable after passing through the gastrointestinal tract and maintain ability to colonize the vagina as well as other organs and are characterized by a high level of adhesion to vaginal epithelial cells, helps to increase the lactobacilli count, normalizing microbiome in the woman’s vagina. The recent clinical trials have demonstrated the efficacy of oral administration of the combination of two strains of lactic acid bacteria, L. rhamnosus HN001 and L. acidophilus La-14, in the prevention of recurrences of bacterial vaginosis and vulvovaginal candidiasis with the aim of maintaining and normalizing vaginal microbiome; this combination is approved for taking during pregnancy and breastfeeding. KEYWORDS: vaginal infections, microbiome, probiotics, oral intake, symbiont bacterial strains, normal vaginal biocenosis. FOR CITATION: Minkina G.N., Bondarenko K.R., Selikhova M.S., Soltys P.A. Renaissance of the vaginal microbiota: reframing clinical paradigms. Russian Journal of Woman and Child Health. 2022;5(4):303–308 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-303-308.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.32364/2618-8430-2021-4-3-254-259
K. A. Pugolovkin, E. Efimova, E. A. Dombrovskaya, I.Yu. Platonova, A. A. Solov’ev
Aim: to assess brain circulation in the regions supplied by the basilar artery (BA) in children with movement disorders and motor skill delay in the late rehabilitative period after hypoxic ischemic encephalopathy and its importance for the objectivity of clinical data and evaluation of rehabilitative effect. Patients and Methods: 28 children (mean age one year seven months) with movement disorders and motor skill delay (after hypoxic ischemic CNS lesion in the perinatal period) without lower extremity paraparesis or Willis circle abnormalities (by Doppler ultrasound) were examined. Doppler ultrasound was performed using the suboccipital approach at 3–8 months with 3–4-month intervals. The parameters of blood flow in BA, i.e., resistivity index (RI) and mean blood flow velocity (Vm), were measured. Retrospectively, children were divided into three groups based on motor skill delay severity (mild, moderate, or severe) and time for standing unaided to walking. Mean values in the groups and relative deviations (increase/decrease) from reference values in a given age group were compared. Results: motor skill delay severity and predicting time for standing unaided to walking correlated with RI and Vm. RI was a diagnostically valuable parameter whose reference values differed from motor skill delay severity. Isolated increase in Vm and normal RI were reported in children with motor skill delay 1–3 months before standing unaided to walking. This type of blood circulation is a transitional one during clinical improvement in some children. Conclusions: a set of instrumental data allow for describing motor skill delay severity depending on RI deviations from normal values in the regions supplied by BA. The sequence of brain circulation parameter changes is in line with the clinical course, e.g., RI normalization and further gradual recovery of blood flow velocity. KEYWORDS: movement disorders, motor skill delay, Transcranial Doppler ultrasound, basilar artery, resistivity index RI, mean blood flow velocity Vm. FOR CITATION: Pugolovkin K.A., Efimova E.A., Dombrovskaya E.A. et al. Transcranial Doppler ultrasound is a diagnostic and predicting tool for movement disorders in children after hypoxic ischemic encephalopathy. Russian Journal of Woman and Child Health. 2021;4(3):254–259 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-254-259.
{"title":"Transcranial Doppler ultrasound is a diagnostic and predicting tool for movement disorders in children after hypoxic ischemic encephalopathy","authors":"K. A. Pugolovkin, E. Efimova, E. A. Dombrovskaya, I.Yu. Platonova, A. A. Solov’ev","doi":"10.32364/2618-8430-2021-4-3-254-259","DOIUrl":"https://doi.org/10.32364/2618-8430-2021-4-3-254-259","url":null,"abstract":"Aim: to assess brain circulation in the regions supplied by the basilar artery (BA) in children with movement disorders and motor skill delay in the late rehabilitative period after hypoxic ischemic encephalopathy and its importance for the objectivity of clinical data and evaluation of rehabilitative effect. Patients and Methods: 28 children (mean age one year seven months) with movement disorders and motor skill delay (after hypoxic ischemic CNS lesion in the perinatal period) without lower extremity paraparesis or Willis circle abnormalities (by Doppler ultrasound) were examined. Doppler ultrasound was performed using the suboccipital approach at 3–8 months with 3–4-month intervals. The parameters of blood flow in BA, i.e., resistivity index (RI) and mean blood flow velocity (Vm), were measured. Retrospectively, children were divided into three groups based on motor skill delay severity (mild, moderate, or severe) and time for standing unaided to walking. Mean values in the groups and relative deviations (increase/decrease) from reference values in a given age group were compared. Results: motor skill delay severity and predicting time for standing unaided to walking correlated with RI and Vm. RI was a diagnostically valuable parameter whose reference values differed from motor skill delay severity. Isolated increase in Vm and normal RI were reported in children with motor skill delay 1–3 months before standing unaided to walking. This type of blood circulation is a transitional one during clinical improvement in some children. Conclusions: a set of instrumental data allow for describing motor skill delay severity depending on RI deviations from normal values in the regions supplied by BA. The sequence of brain circulation parameter changes is in line with the clinical course, e.g., RI normalization and further gradual recovery of blood flow velocity. KEYWORDS: movement disorders, motor skill delay, Transcranial Doppler ultrasound, basilar artery, resistivity index RI, mean blood flow velocity Vm. FOR CITATION: Pugolovkin K.A., Efimova E.A., Dombrovskaya E.A. et al. Transcranial Doppler ultrasound is a diagnostic and predicting tool for movement disorders in children after hypoxic ischemic encephalopathy. Russian Journal of Woman and Child Health. 2021;4(3):254–259 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-254-259.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69542541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.32364/2618-8430-2021-4-3-302-307
G. S. Karpovich, I. V. Kuimova, E. Krasnova, D. S. Maramygin, A.Yu. Enikeev
Toxic shock syndrome (TSS) is a complex of symptoms that includes fever, exanthem, multiple organ dysfunction syndrome, and hypotension. The most common causative agents are S. aureus and group A Streptococcus. TSS is characterized by severe course and high mortality in the lack of specific complex treatment. This article addresses a case report of staphylococcal TSS in a 5-year-old girl. The primary focus of infection (infected right leg wound) and breakthrough factors (the lack of adequate wound care) resulted in the dissemination of causative agent and TSS development. Despite disease severity, early complex etiological (antibiotics) and pathogenically-oriented (infusions, corticosteroids) treatment improved the patient’s condition and promoted recovery. This case report illustrating the classic presentations of staphylococcal TSS in children is helpful for pediatricians in terms of awareness of this pathological condition. KEYWORDS: infectious diseases, staphylococcus aureus, toxic shock syndrome, cytokine storm, multiple organ failure syndrome, pediatrics. FOR CITATION: Karpovich G.S., Kuimova I.V., Krasnova E.I. et al. Staphylococcal toxic shock syndrome in a child. Case report. Russian Journal of Woman and Child Health. 2021;4(3):302–307 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-302-307.
{"title":"Staphylococcal toxic shock syndrome in a child. Case report","authors":"G. S. Karpovich, I. V. Kuimova, E. Krasnova, D. S. Maramygin, A.Yu. Enikeev","doi":"10.32364/2618-8430-2021-4-3-302-307","DOIUrl":"https://doi.org/10.32364/2618-8430-2021-4-3-302-307","url":null,"abstract":"Toxic shock syndrome (TSS) is a complex of symptoms that includes fever, exanthem, multiple organ dysfunction syndrome, and hypotension. The most common causative agents are S. aureus and group A Streptococcus. TSS is characterized by severe course and high mortality in the lack of specific complex treatment. This article addresses a case report of staphylococcal TSS in a 5-year-old girl. The primary focus of infection (infected right leg wound) and breakthrough factors (the lack of adequate wound care) resulted in the dissemination of causative agent and TSS development. Despite disease severity, early complex etiological (antibiotics) and pathogenically-oriented (infusions, corticosteroids) treatment improved the patient’s condition and promoted recovery. This case report illustrating the classic presentations of staphylococcal TSS in children is helpful for pediatricians in terms of awareness of this pathological condition. KEYWORDS: infectious diseases, staphylococcus aureus, toxic shock syndrome, cytokine storm, multiple organ failure syndrome, pediatrics. FOR CITATION: Karpovich G.S., Kuimova I.V., Krasnova E.I. et al. Staphylococcal toxic shock syndrome in a child. Case report. Russian Journal of Woman and Child Health. 2021;4(3):302–307 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-302-307.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69542852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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