Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-35-40
M. Selikhova, A.A. Smol’yaninov
Pelvic inflammatory disease (PID) is an important issue due to its high occurrence in women of reproductive age and adverse effects on reproductive function. In 2021, the Ministry of Health of the Russian Federation had approved clinical guidelines that standardized management and treatment approaches to PID. These novel clinical guidelines focus on rational outpatient antimicrobial therapy using broad-spectrum medications. Treatment is prescribed empirically considering the predominant polymicrobial nature of PID. Opportunistic microbes (i.e., obligatory and facultative anaerobes) increasingly become causative agents of PID. Low titers of these microbes are found in the normal vaginal microflora, favoring broad-spectrum antibiotics effective against gram-positive and gram-negative bacteria. Treatment duration should be at least 10–14 days to completely eradicate the pathogen and prevent chronicity. Attention should be focused on choosing antibiotics with favorable safety profiles. KEYWORDS: pelvic inflammatory disease, clinical guidelines, outpatient treatment, antibiotics, doxycycline, dispersible tablet, adherence. FOR CITATION: Selikhova M.S., Smol’yaninov A.A. State-of-the-art therapy for salpingo-oophoritis from the perspective of novel clinical guidelines. Russian Journal of Woman and Child Health. 2022;5(1):35–40 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-35-40.
{"title":"State-of-the-art therapy for salpingo-oophoritis from the perspective of novel clinical guidelines","authors":"M. Selikhova, A.A. Smol’yaninov","doi":"10.32364/2618-8430-2022-5-1-35-40","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-35-40","url":null,"abstract":"Pelvic inflammatory disease (PID) is an important issue due to its high occurrence in women of reproductive age and adverse effects on reproductive function. In 2021, the Ministry of Health of the Russian Federation had approved clinical guidelines that standardized management and treatment approaches to PID. These novel clinical guidelines focus on rational outpatient antimicrobial therapy using broad-spectrum medications. Treatment is prescribed empirically considering the predominant polymicrobial nature of PID. Opportunistic microbes (i.e., obligatory and facultative anaerobes) increasingly become causative agents of PID. Low titers of these microbes are found in the normal vaginal microflora, favoring broad-spectrum antibiotics effective against gram-positive and gram-negative bacteria. Treatment duration should be at least 10–14 days to completely eradicate the pathogen and prevent chronicity. Attention should be focused on choosing antibiotics with favorable safety profiles. KEYWORDS: pelvic inflammatory disease, clinical guidelines, outpatient treatment, antibiotics, doxycycline, dispersible tablet, adherence. FOR CITATION: Selikhova M.S., Smol’yaninov A.A. State-of-the-art therapy for salpingo-oophoritis from the perspective of novel clinical guidelines. Russian Journal of Woman and Child Health. 2022;5(1):35–40 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-35-40.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69548028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-169-172
N. Akhmina, P.S. Utkin, M. Shalatonin, Z. Chabaidze, A.A. Dement’ev, A. Zaplatnikov
Scleroderma is a rare condition in pediatrics although it ranks third (after juvenile idiopathic arthritis and systemic lupus erythematosus) among rheumatic diseases in children. Congenital scleroderma is considered casuistic since only single case reports are available in publications worldwide. The etiology of congenital scleroderma remains elusive. The principal pathogenic mechanisms are vascular network impairment, immune system dysfunction with abnormal regulation of cytokine release and altered collagen synthesis with fibroblast proliferation and fibrosis. This paper describes a newborn girl with congenital localized nodular scleroderma whose clinical presentations were detected at birth. The authors discuss difficulties with the diagnosis based on clinical and routine lab and instrumental tests. The role of modern morphological studies (given the lack of specific lab tests) to diagnose scleroderma in a newborn is emphasized. Finally, this paper provides a brief review of published data on congenital scleroderma. KEYWORDS: congenital scleroderma, children, diagnostics, differential diagnosis, morphological studies. FOR CITATION: Akhmina N.I., Utkin P.S., Shalatonin M.P. et al. Localized scleroderma in a newborn (case report). Russian Journal of Woman and Child Health. 2022;5(2):169–172 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-169-172.
{"title":"Localized scleroderma in a newborn (case report)","authors":"N. Akhmina, P.S. Utkin, M. Shalatonin, Z. Chabaidze, A.A. Dement’ev, A. Zaplatnikov","doi":"10.32364/2618-8430-2022-5-2-169-172","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-169-172","url":null,"abstract":"Scleroderma is a rare condition in pediatrics although it ranks third (after juvenile idiopathic arthritis and systemic lupus erythematosus) among rheumatic diseases in children. Congenital scleroderma is considered casuistic since only single case reports are available in publications worldwide. The etiology of congenital scleroderma remains elusive. The principal pathogenic mechanisms are vascular network impairment, immune system dysfunction with abnormal regulation of cytokine release and altered collagen synthesis with fibroblast proliferation and fibrosis. This paper describes a newborn girl with congenital localized nodular scleroderma whose clinical presentations were detected at birth. The authors discuss difficulties with the diagnosis based on clinical and routine lab and instrumental tests. The role of modern morphological studies (given the lack of specific lab tests) to diagnose scleroderma in a newborn is emphasized. Finally, this paper provides a brief review of published data on congenital scleroderma. KEYWORDS: congenital scleroderma, children, diagnostics, differential diagnosis, morphological studies. FOR CITATION: Akhmina N.I., Utkin P.S., Shalatonin M.P. et al. Localized scleroderma in a newborn (case report). Russian Journal of Woman and Child Health. 2022;5(2):169–172 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-169-172.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-41-45
M. Selikhova, T. I. Kostenko, A.A. Smol’yaninov
Vaginal discharge is the most common reason for referral to a gynecologist. Given the polyetiological nature of vaginal infections, broad- spectrum medications are selected for treatment. Antiseptic solutions (whose efficacy is similar to antibiotics) included in Russian clinical guidelines for obstetrics and gynecology are now more favored. Chlorohexidine is the most studied antiseptic solution with established efficacy in obstetrics and gynecology, whose hallmark is the lack of inhibiting effects on Lactobacilli and local immunity. Combining chlorohexidine and dexpanthenol is one of the most promising therapeutic tools for bacterial vaginosis and vaginal infections. Dexpanthenol stimulates reparation and recovering vaginal and cervical mucosal integrity. This property is crucial for reducing inflammation and preventing recurrences. Recent multicenter randomized and observational study results have demonstrated high efficacy, safety, and good tolerability of combined preparation for vulvovaginitis of different etiologies and vaginal dysbiosis in women of reproductive age, postmenopausal and pregnant women, and while breastfeeding. KEYWORDS: vaginal dysbiosis, vulvovaginitis, antiseptic, broad-spectrum, Lactobacilli, reparative. FOR CITATION: Selikhova M.S., Kostenko T.I., Smol’yaninov A.A. Rational therapy for vaginal infections is a gynecologist’s choice. Russian Journal of Woman and Child Health. 2022;5(1):41–45 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-41-45.
{"title":"Rational therapy for vaginal infections is a gynecologist’s choice","authors":"M. Selikhova, T. I. Kostenko, A.A. Smol’yaninov","doi":"10.32364/2618-8430-2022-5-1-41-45","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-41-45","url":null,"abstract":"Vaginal discharge is the most common reason for referral to a gynecologist. Given the polyetiological nature of vaginal infections, broad- spectrum medications are selected for treatment. Antiseptic solutions (whose efficacy is similar to antibiotics) included in Russian clinical guidelines for obstetrics and gynecology are now more favored. Chlorohexidine is the most studied antiseptic solution with established efficacy in obstetrics and gynecology, whose hallmark is the lack of inhibiting effects on Lactobacilli and local immunity. Combining chlorohexidine and dexpanthenol is one of the most promising therapeutic tools for bacterial vaginosis and vaginal infections. Dexpanthenol stimulates reparation and recovering vaginal and cervical mucosal integrity. This property is crucial for reducing inflammation and preventing recurrences. Recent multicenter randomized and observational study results have demonstrated high efficacy, safety, and good tolerability of combined preparation for vulvovaginitis of different etiologies and vaginal dysbiosis in women of reproductive age, postmenopausal and pregnant women, and while breastfeeding. KEYWORDS: vaginal dysbiosis, vulvovaginitis, antiseptic, broad-spectrum, Lactobacilli, reparative. FOR CITATION: Selikhova M.S., Kostenko T.I., Smol’yaninov A.A. Rational therapy for vaginal infections is a gynecologist’s choice. Russian Journal of Woman and Child Health. 2022;5(1):41–45 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-41-45.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69548091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-194-200
A. V. Smirnova, A. Malyshkina, I.A. Kolganova, N.V. Shekhlova, Z.S. Abdullaeva
Background: descent of pelvic organs (genital prolapse, GP) of different severity is a significant medical and social problem. The key clinical manifestations in patients with GP comprise the impairment of pelvic organ functions which seriously affects the social adaptation of such patients. Aim: to assess specific clinical characteristics of the functional disorders of pelvic organs in patients with GP admitted for surgical treatment and to review changes in symptoms over time after surgery. Patients and Methods: a non-randomized prospective cohort study was carried out. The study group included 40 patients with different forms of GP, Grades II-IV under POP-Q classification system. All patients were interviewed before and 6 months after the surgical treatment using a new short version of PFDI-20 Questionnaire. Results: urinations disorders with a duration shorter than one year were reported in 19 (47%) women, from 1 year to 5 years — in 13(32,5%), from 5 to 10 years — in 1 (2,5%), and in 4 (10%) women the symptoms lasted for more than 10 years. It was found that 12(30%) of the interviewed women suffered from constipation, and 11 (27.5%) of patients had the feeling of incomplete defecation. Twelve (30%) patients complained of fecal and flatus incontinence. Six months after the operation, 7 (17.5%) patients mentioned some pain and discomfort in the lower abdomen. Urination disorders (urine dribble and incontinence, urethrodynia). Flatus incontinence remained in 3 (7.5) of the studied patients.
{"title":"Characteristics of the pelvic organ dysfunctions in patients before and after genital prolapse surgery","authors":"A. V. Smirnova, A. Malyshkina, I.A. Kolganova, N.V. Shekhlova, Z.S. Abdullaeva","doi":"10.32364/2618-8430-2022-5-3-194-200","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-194-200","url":null,"abstract":"Background: descent of pelvic organs (genital prolapse, GP) of different severity is a significant medical and social problem. The key clinical manifestations in patients with GP comprise the impairment of pelvic organ functions which seriously affects the social adaptation of such patients. Aim: to assess specific clinical characteristics of the functional disorders of pelvic organs in patients with GP admitted for surgical treatment and to review changes in symptoms over time after surgery. Patients and Methods: a non-randomized prospective cohort study was carried out. The study group included 40 patients with different forms of GP, Grades II-IV under POP-Q classification system. All patients were interviewed before and 6 months after the surgical treatment using a new short version of PFDI-20 Questionnaire. Results: urinations disorders with a duration shorter than one year were reported in 19 (47%) women, from 1 year to 5 years — in 13(32,5%), from 5 to 10 years — in 1 (2,5%), and in 4 (10%) women the symptoms lasted for more than 10 years. It was found that 12(30%) of the interviewed women suffered from constipation, and 11 (27.5%) of patients had the feeling of incomplete defecation. Twelve (30%) patients complained of fecal and flatus incontinence. Six months after the operation, 7 (17.5%) patients mentioned some pain and discomfort in the lower abdomen. Urination disorders (urine dribble and incontinence, urethrodynia). Flatus incontinence remained in 3 (7.5) of the studied patients.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-201-208
Y. Dobrokhotova, E. Markova
Nowadays, iron-deficiency anemia (IDA) in pregnant and perimenopausal women has become an important social and healthcare problem. Despite the implementation of various projects and the availability of multiple clinical guidelines on early anemia diagnosis and prevention, no significant reduction in the global prevalence of IDA is observed. The article discusses the clinical efficacy of a new combination drug, containing ferrous sulfate and folic acid which is used for the treatment of iron deficiency during pregnancy, and the assessment of ferrous sulfate efficacy in perimenopausal women. The article presents a review of literature sources published in the last five years which describe the trials of sustained-release bivalent iron formulations with and without folic acid. The drugs were administered to women with gynecologic diseases that caused a chronic iron loss during menopause and to patients with iron deficiency during pregnancy. The authors discuss the most important findings of the clinical trials assessing sustained-release bivalent iron formulation and its combination with folic acid which were used for treating pregnant women and gynecological patients of different ages. The literature data demonstrate that the combination drug, containing ferrous sulfate and folic acid is characterized by high clinical efficacy in the studied female populations with IDA. KEYWORDS: sideropenia, iron deficiency, iron-deficiency anemia, pregnancy, bivalent iron, folic acid, menopause, perimenopause, gynecological diseases. FOR CITATION: Dobrokhotova Yu.E., Markova E.A. New treatment options for iron deficiency in women of different ages. Russian Journal of Woman and Child Health. 2022;5(3):201–208 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-201-208.
{"title":"New treatment options for iron deficiency in women of different ages","authors":"Y. Dobrokhotova, E. Markova","doi":"10.32364/2618-8430-2022-5-3-201-208","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-201-208","url":null,"abstract":"Nowadays, iron-deficiency anemia (IDA) in pregnant and perimenopausal women has become an important social and healthcare problem. Despite the implementation of various projects and the availability of multiple clinical guidelines on early anemia diagnosis and prevention, no significant reduction in the global prevalence of IDA is observed. The article discusses the clinical efficacy of a new combination drug, containing ferrous sulfate and folic acid which is used for the treatment of iron deficiency during pregnancy, and the assessment of ferrous sulfate efficacy in perimenopausal women. The article presents a review of literature sources published in the last five years which describe the trials of sustained-release bivalent iron formulations with and without folic acid. The drugs were administered to women with gynecologic diseases that caused a chronic iron loss during menopause and to patients with iron deficiency during pregnancy. The authors discuss the most important findings of the clinical trials assessing sustained-release bivalent iron formulation and its combination with folic acid which were used for treating pregnant women and gynecological patients of different ages. The literature data demonstrate that the combination drug, containing ferrous sulfate and folic acid is characterized by high clinical efficacy in the studied female populations with IDA. KEYWORDS: sideropenia, iron deficiency, iron-deficiency anemia, pregnancy, bivalent iron, folic acid, menopause, perimenopause, gynecological diseases. FOR CITATION: Dobrokhotova Yu.E., Markova E.A. New treatment options for iron deficiency in women of different ages. Russian Journal of Woman and Child Health. 2022;5(3):201–208 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-201-208.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-270-276
N. A. Polyanskaya, A. Gorbunova, E. Pavlinova, O. Savchenko, I. Kirshina, M. Bagaeva, T. Strokova
Aim: to present the treatment results and the trend of clinical and biochemical parameters in two patients with lysosomal acid lipase deficiency (LALD) during enzyme replacement therapy (ERT). The reasons for the in-depth study of patients were the periorbital "shadows of intoxication" (hyperpigmentation), an increase in the liver and spleen sizes, revealed during medical examination, as well as the long-term subfebrility. Nonspecific clinical disease manifestations required an extended diagnostic search. LALD diagnosis, confirmed by the molecular genetic study results, was made at the age of 7 and 12 years. In both clinical cases, the prescription of pathogenetically based therapy provided positive trend in the form of improvement in physical development, reduction in the liver and spleen sizes, and persistent relief of hepatic cytolysis. The article considers the difficulties that a medical practitioner may face when monitoring patients with LALD receiving pathogenetic therapy. Special attention is paid to the possible causes of insufficiently effective reduction of cholesterol levels during ERT. The article also notes the importance of timely diagnosis of LALD, characterized by continuous pathological storage of cholesteryl esters in lysosomes, which is associated with the risk of irreversible lesions of organs and tissues. KEYWORDS: children, Lysosomal acid lipase deficiency, cholesteryl ester storage disease, dyslipidemia, cytolysis, sebelipase alfa, enzyme replacement therapy. FOR CITATION: Polyanskaya N.A., Gorbunova A.A., Pavlinova E.B. et al. Lysosomal acid lipase deficiency: analysis of enzyme replacement therapy. Russian Journal of Woman and Child Health. 2022;5(3):270–276 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-270-276.
{"title":"Lysosomal acid lipase deficiency: analysis of enzyme replacement therapy","authors":"N. A. Polyanskaya, A. Gorbunova, E. Pavlinova, O. Savchenko, I. Kirshina, M. Bagaeva, T. Strokova","doi":"10.32364/2618-8430-2022-5-3-270-276","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-270-276","url":null,"abstract":"Aim: to present the treatment results and the trend of clinical and biochemical parameters in two patients with lysosomal acid lipase deficiency (LALD) during enzyme replacement therapy (ERT). The reasons for the in-depth study of patients were the periorbital \"shadows of intoxication\" (hyperpigmentation), an increase in the liver and spleen sizes, revealed during medical examination, as well as the long-term subfebrility. Nonspecific clinical disease manifestations required an extended diagnostic search. LALD diagnosis, confirmed by the molecular genetic study results, was made at the age of 7 and 12 years. In both clinical cases, the prescription of pathogenetically based therapy provided positive trend in the form of improvement in physical development, reduction in the liver and spleen sizes, and persistent relief of hepatic cytolysis. The article considers the difficulties that a medical practitioner may face when monitoring patients with LALD receiving pathogenetic therapy. Special attention is paid to the possible causes of insufficiently effective reduction of cholesterol levels during ERT. The article also notes the importance of timely diagnosis of LALD, characterized by continuous pathological storage of cholesteryl esters in lysosomes, which is associated with the risk of irreversible lesions of organs and tissues. KEYWORDS: children, Lysosomal acid lipase deficiency, cholesteryl ester storage disease, dyslipidemia, cytolysis, sebelipase alfa, enzyme replacement therapy. FOR CITATION: Polyanskaya N.A., Gorbunova A.A., Pavlinova E.B. et al. Lysosomal acid lipase deficiency: analysis of enzyme replacement therapy. Russian Journal of Woman and Child Health. 2022;5(3):270–276 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-270-276.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-277-283
T. A. Bokova, E. S. Vakurova, A. N. Verbovsky, A. S. Bevz, A.R. Temendarov, O. A. Bokova
The article describes a clinical case of late-diagnosed bronchial foreign body aspiration in a 14-year-old girl. The unusual clinical course and patient’s complaints, the lack of primary care physicians’ awareness caused the diagnostic delay and underpinned the initial misdiagnosis (pneumonia, acute tracheitis, bronchitis, lung abscess, TB-infection suspicion). The diagnostic errors led to the improper case management and the unjustified administration of repeated courses of antibiotics, and multiple X-ray examinations. Bronchoscopy which helped to make the final diagnosis and allowed removing the foreign body from the bronchus, was performed only nine months after the onset of clinical symptoms and patient’s complaints. The article is discussing all stages of diagnostic process, both during outpatient follow-up and in hospital settings. The emphasis is put on the importance of collecting patient’s health history which led to the suspicion for an airway foreign body. The bronchoscopy tactics are described as the main diagnostic and therapeutic method for identifying and removing a foreign body from the respiratory tract. Based on the appropriate sequence of steps and the accuracy of manipulation, all bronchoscopy stages were completed without complications, and all clinical symptoms relieved. KEYWORDS: foreign body, children, tracheobronchial tree, bronchoscopy, lavage. FOR CITATION: Bokova T.A., Vakurova E.S., Verbovsky A.N. et al. Late diagnosis of bronchial foreign body aspiration in a 14-year-old teenager. Russian Journal of Woman and Child Health. 2022;5(3):277–283 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-277-283.
{"title":"Late diagnosis of bronchial foreign body aspiration in a 14-year-old teenager","authors":"T. A. Bokova, E. S. Vakurova, A. N. Verbovsky, A. S. Bevz, A.R. Temendarov, O. A. Bokova","doi":"10.32364/2618-8430-2022-5-3-277-283","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-277-283","url":null,"abstract":"The article describes a clinical case of late-diagnosed bronchial foreign body aspiration in a 14-year-old girl. The unusual clinical course and patient’s complaints, the lack of primary care physicians’ awareness caused the diagnostic delay and underpinned the initial misdiagnosis (pneumonia, acute tracheitis, bronchitis, lung abscess, TB-infection suspicion). The diagnostic errors led to the improper case management and the unjustified administration of repeated courses of antibiotics, and multiple X-ray examinations. Bronchoscopy which helped to make the final diagnosis and allowed removing the foreign body from the bronchus, was performed only nine months after the onset of clinical symptoms and patient’s complaints. The article is discussing all stages of diagnostic process, both during outpatient follow-up and in hospital settings. The emphasis is put on the importance of collecting patient’s health history which led to the suspicion for an airway foreign body. The bronchoscopy tactics are described as the main diagnostic and therapeutic method for identifying and removing a foreign body from the respiratory tract. Based on the appropriate sequence of steps and the accuracy of manipulation, all bronchoscopy stages were completed without complications, and all clinical symptoms relieved. KEYWORDS: foreign body, children, tracheobronchial tree, bronchoscopy, lavage. FOR CITATION: Bokova T.A., Vakurova E.S., Verbovsky A.N. et al. Late diagnosis of bronchial foreign body aspiration in a 14-year-old teenager. Russian Journal of Woman and Child Health. 2022;5(3):277–283 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-277-283.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-326-331
O.V Barakina, T. Markova, S. G. Ismailova, I. Godkov, V.M. Grabovsky, P. Kozlov
The authors present a clinical case of partial hypopituitarism developed in a 31-year-old patient during the first trimester of pregnancy after the surgical treatment of hemorrhagic pituitary adenoma. The onset of the diseases was recorded on the 12th week of pregnancy and was characterized by such specific clinical manifestations as severe headache, multiple spells of vomiting, diplopia and right-sided ptosis. The contrast-enhanced MRI revealed a pituitary adenoma with a "fresh" hemorrhage and the destruction of anterior wall and floor of the sella turcica, and the invasion into the sphenoid and right cavernous sinuses. The patient underwent emergency surgery – the endoscopic endonasal approach for total resection of pituitary adenoma. Hypopituitarism manifestations identified in the postoperative period were relieved by hormone replacement therapy. A timely diagnosis and prompt decision on the surgical treatment of pituitary adenoma, as well as a multidisciplinary team approach to patient care ensured the appropriate management of the underlying disease, successful pregnancy, childbirth outcome and high maternal quality of life. KEYWORDS: pituitary adenoma, pregnancy, management practices, hemorrhage, pituitary apoplexy, hypopituitarism, surgical treatment. FOR CITATION: Barakina O.V., Markova T.N., Ismailova S.G. et al. Successful pregnancy and delivery outcome after the surgical treatment of pituitary adenoma in the first trimester of pregnancy (a clinical case). Russian Journal of Woman and Child Health. 2022;5(4):326–331 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-326-331.
{"title":"Successful pregnancy and delivery outcome after the surgical treatment of pituitary adenoma in the first trimester of pregnancy (a clinical case)","authors":"O.V Barakina, T. Markova, S. G. Ismailova, I. Godkov, V.M. Grabovsky, P. Kozlov","doi":"10.32364/2618-8430-2022-5-4-326-331","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-326-331","url":null,"abstract":"The authors present a clinical case of partial hypopituitarism developed in a 31-year-old patient during the first trimester of pregnancy after the surgical treatment of hemorrhagic pituitary adenoma. The onset of the diseases was recorded on the 12th week of pregnancy and was characterized by such specific clinical manifestations as severe headache, multiple spells of vomiting, diplopia and right-sided ptosis. The contrast-enhanced MRI revealed a pituitary adenoma with a \"fresh\" hemorrhage and the destruction of anterior wall and floor of the sella turcica, and the invasion into the sphenoid and right cavernous sinuses. The patient underwent emergency surgery – the endoscopic endonasal approach for total resection of pituitary adenoma. Hypopituitarism manifestations identified in the postoperative period were relieved by hormone replacement therapy. A timely diagnosis and prompt decision on the surgical treatment of pituitary adenoma, as well as a multidisciplinary team approach to patient care ensured the appropriate management of the underlying disease, successful pregnancy, childbirth outcome and high maternal quality of life. KEYWORDS: pituitary adenoma, pregnancy, management practices, hemorrhage, pituitary apoplexy, hypopituitarism, surgical treatment. FOR CITATION: Barakina O.V., Markova T.N., Ismailova S.G. et al. Successful pregnancy and delivery outcome after the surgical treatment of pituitary adenoma in the first trimester of pregnancy (a clinical case). Russian Journal of Woman and Child Health. 2022;5(4):326–331 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-326-331.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-297-302
Y. Dobrokhotova, P. A. Shadrova
Background: the research is still focused on bacterial vaginosis (BV) in view of its high prevalence among women and potential damaging effects on fertility The treatment regimens which are presented in the current guidelines and available for obstetricians and gynecologists may cause adverse local and systemic effects. In addition, female patients frequently experience BV recurrences. Aim: to assess the efficacy of taking secnidazole once as a single dose in the treatment of BV based on clinical findings and laboratory-based test results Patients and Methods: the study included 40 female patients with diagnosed BV. The patients were split into two groups, 20 women in each group. The treatment group patients received secnidazole 2 g once as a single dose, and the control group patients received the standard treatment with metronidazole 500 mg twice daily for 7 days. The evaluation of patients included the vaginal pH value and laboratory-based diagnostic tests, such as microscopy of the vaginal discharge and Florocenosis/Bacterial vaginosis-FRT PCR assay whose prognostic value indicators are comparable with the international clinical and laboratory-based diagnostic criteria. Results: before therapy, the mean leucocyte count in the vaginal smear in the treatment group patients was 12.4±3.0 per field of vision and in the control group patients — 11.3±1.8; after therapy — 9.2±1.2 and 10.1±4.4, respectively. A statistically significant decrease (р<0.05) in vaginal pH was recorded after the therapy: to 4.4±0.1 in the treatment group and 4.3±0.1 in the control group. The average concentration of BV-associated species after the administered therapy was lower than that at the baseline (the difference was statistically significant). Conclusion: сonsidering the comparable clinical and microbiological outcomes of the alternative and standard BV treatment regimens, as well as the convenience of administration associated with single-dose therapy, secnidazole can be used to treat bacterial vaginosis. KEYWORDS: bacterial vaginosis, microbiota, pelvic inflammatory disease, secnidazole, metronidazole. FOR CITATION: Dobrokhotova Yu.E., Shadrova P.A. Therapeutic capabilities of secnidazole in the treatment of bacterial vaginosis. Russian Journal of Woman and Child Health. 2022;5(4):297–302 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-297-302.
{"title":"Therapeutic capabilities of secnidazole in the treatment of bacterial vaginosis","authors":"Y. Dobrokhotova, P. A. Shadrova","doi":"10.32364/2618-8430-2022-5-4-297-302","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-297-302","url":null,"abstract":"Background: the research is still focused on bacterial vaginosis (BV) in view of its high prevalence among women and potential damaging effects on fertility The treatment regimens which are presented in the current guidelines and available for obstetricians and gynecologists may cause adverse local and systemic effects. In addition, female patients frequently experience BV recurrences. Aim: to assess the efficacy of taking secnidazole once as a single dose in the treatment of BV based on clinical findings and laboratory-based test results Patients and Methods: the study included 40 female patients with diagnosed BV. The patients were split into two groups, 20 women in each group. The treatment group patients received secnidazole 2 g once as a single dose, and the control group patients received the standard treatment with metronidazole 500 mg twice daily for 7 days. The evaluation of patients included the vaginal pH value and laboratory-based diagnostic tests, such as microscopy of the vaginal discharge and Florocenosis/Bacterial vaginosis-FRT PCR assay whose prognostic value indicators are comparable with the international clinical and laboratory-based diagnostic criteria. Results: before therapy, the mean leucocyte count in the vaginal smear in the treatment group patients was 12.4±3.0 per field of vision and in the control group patients — 11.3±1.8; after therapy — 9.2±1.2 and 10.1±4.4, respectively. A statistically significant decrease (р<0.05) in vaginal pH was recorded after the therapy: to 4.4±0.1 in the treatment group and 4.3±0.1 in the control group. The average concentration of BV-associated species after the administered therapy was lower than that at the baseline (the difference was statistically significant). Conclusion: сonsidering the comparable clinical and microbiological outcomes of the alternative and standard BV treatment regimens, as well as the convenience of administration associated with single-dose therapy, secnidazole can be used to treat bacterial vaginosis. KEYWORDS: bacterial vaginosis, microbiota, pelvic inflammatory disease, secnidazole, metronidazole. FOR CITATION: Dobrokhotova Yu.E., Shadrova P.A. Therapeutic capabilities of secnidazole in the treatment of bacterial vaginosis. Russian Journal of Woman and Child Health. 2022;5(4):297–302 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-297-302.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-373-381
O.S. Pen’tkovskaya, S. I. Bardenikova
Dynamic intestinal obstruction (DIO) is one of the disorders reported after gastrointestinal (GI) surgical procedures. DIO raises special concerns, as it affects patients’ condition in the postoperative period and increases the duration of hospital treatment. The review section of the article is focused on DIO pathogenetic mechanisms, clinical manifestations, diagnostic criteria, and treatment strategies. In addition to diet therapy and the use of cholinesterase inhibitors, the conservative therapy in children includes various physiotherapy treatment techniques, facilitating intestinal motility The comparative analysis shows that their ultimate efficiency is not the same and that there are significant limitations and differences associated with the access to the optimal areas for electrode placement The article presents the results of introducing an original technique of dynamic electrical stimulation of the intestine with point paravertebral massage which was used in the early postoperative period for 117 children. The children had undergone either emergency surgeries in cases of acute surgical conditions or planned (stage-by- stage) intestinal reconstruction surgeries for preventing DIO.The data have demonstrated the efficacy of electrical stimulation used both as monotherapy and in combination with proserine (the number of required injections was decreased to 1 or 2). Restoration of the intestinal passage was achieved in 95% of cases within the first 24–36 hours after surgery (spontaneous defecation occurred in 70% of patients by the end of the first day). A later response to electrical stimulation with the restoration of peristalsis was determined after small intestine surgeries: spontaneous emptying of the intestine on the first day occurred only in 43% of children versus 52% after surgery of the lower portion of the abdominal cavity KEYWORDS: postoperative intestinal paresis; children; clinical course; diagnostics; electrical stimulation; original technique; acupressure device FOR CITATION: Pen’tkovskaya O.S., Bardenikova S.I. Prevention and treatment of enteroparesis in children. Russian Journal of Woman and Child Health. 2022;5(4):373–381 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-373-381.
{"title":"Prevention and treatment of enteroparesis in children","authors":"O.S. Pen’tkovskaya, S. I. Bardenikova","doi":"10.32364/2618-8430-2022-5-4-373-381","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-373-381","url":null,"abstract":"Dynamic intestinal obstruction (DIO) is one of the disorders reported after gastrointestinal (GI) surgical procedures. DIO raises special concerns, as it affects patients’ condition in the postoperative period and increases the duration of hospital treatment. The review section of the article is focused on DIO pathogenetic mechanisms, clinical manifestations, diagnostic criteria, and treatment strategies. In addition to diet therapy and the use of cholinesterase inhibitors, the conservative therapy in children includes various physiotherapy treatment techniques, facilitating intestinal motility The comparative analysis shows that their ultimate efficiency is not the same and that there are significant limitations and differences associated with the access to the optimal areas for electrode placement The article presents the results of introducing an original technique of dynamic electrical stimulation of the intestine with point paravertebral massage which was used in the early postoperative period for 117 children. The children had undergone either emergency surgeries in cases of acute surgical conditions or planned (stage-by- stage) intestinal reconstruction surgeries for preventing DIO.The data have demonstrated the efficacy of electrical stimulation used both as monotherapy and in combination with proserine (the number of required injections was decreased to 1 or 2). Restoration of the intestinal passage was achieved in 95% of cases within the first 24–36 hours after surgery (spontaneous defecation occurred in 70% of patients by the end of the first day). A later response to electrical stimulation with the restoration of peristalsis was determined after small intestine surgeries: spontaneous emptying of the intestine on the first day occurred only in 43% of children versus 52% after surgery of the lower portion of the abdominal cavity KEYWORDS: postoperative intestinal paresis; children; clinical course; diagnostics; electrical stimulation; original technique; acupressure device FOR CITATION: Pen’tkovskaya O.S., Bardenikova S.I. Prevention and treatment of enteroparesis in children. Russian Journal of Woman and Child Health. 2022;5(4):373–381 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-373-381.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69551147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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