Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-320-325
E. Antropova, B. Sharafutdinov, M. I. Mazitova, S. Ryzhkin, I. V. Abdul’yanov, Ya.V. Prokop’ev
Congenital anomalies of the urogenital system constitute approximately 20 to 30% of all birth defects. Renal dystopia means a congenital abnormal location of one or both kidneys. The authors present a clinical case report, demonstrating the efficacy of uterine artery embolization as an alternative method of treatment for patients with uterine fibroids and renal dystopia. Uterine artery embolization is not only an organ- preserving treatment option for women who wish to retain the reproductive organ but also offers a clear visualization of the individual anatomical variations. Taking into consideration a strong patient’s wish to preserve the uterus and her individual vascular anomalies (absence of the left uterine and renal arteries), uterine artery embolization was an alternative treatment option which enabled to preserve both the uterus and the left kidney. The scheduled examination findings demonstrated a 1.87-fold reduction of the uterine volume and a 12.8-fold reduction of the fibroid size from baseline, and color doppler ultrasonography revealed that the uterine fibroid was avascular. For patients with diagnosed congenital anomalies of the urogenital system, the authors recommend using computer tomography and referrals to interdisciplinary specialists for choosing the appropriate uterine fibroid treatment options KEYWORDS: uterine fibroids, pelvic kidney dystopia, uterine artery embolization, organ-preserving treatment methods, congenital anomalies of the urogenital system, computer tomography. FOR CITATION: Antropova E.Yu., Sharafutdinov B.M., Mazitova M.I. et al. Organ-preserving approach to the treatment of patients with uterine fibroids and congenital anomaly of the urinary system (a clinical case). Russian Journal of Woman and Child Health. 2022;5(4):320–325 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-320-325.
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Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-292-296
V. Kuzmin
Aim: to assess the efficacy and safety of Ecofucin® in patients after performing planned gynecologic surgery procedures based on the changes in vaginal microbiota over time amid the use of systemic antimicrobial therapy (AMT). Patients and Methods: this prospective open randomized comparative parallel-group clinical study involved patients without signs of vaginal microbiota dysbiosis — bacterial vaginosis or candidiasis, who were hospitalized for planned surgery procedures. The group 1 patients (n=39) received systemic AMT and Ecofucin® for intravaginal application once a day at the bedtime for 12 days, starting 6 days before the planned surgery and AMT initiation, while the group 2 patients (n=40) received only systemic AMT. The efficacy was assessed a day after the completion of AMT and the use of the tested medication (i.e. on day 13 after the initiation of Ecofucin application) and 30±2 days after the initiation of using the tested drug. Clinical, microbiological and molecular genetic methods were used for the assessment. Results: symptoms common for vaginal microbiota dysbiosis — bacterial vaginosis and candidiasis were reported by 18% and 21% of the group 2 patients at days 13 and 30±2 after the initiation of AMT, while such symptoms were not recorded in any of the group 1 patients (F=0,107, р=0,007). In 100% of the group 1 patients both lactobacilli and bifidobacteria were detected at all endpoints. In group 2, lactobacilli were found at days 13 and 30±2 in 93.8% and 97% of patients, respectively (F=0.035, p=0.2; F=0.017, p=0.458), bifidobacteria — in 84.4% and 81.1% of patients, respectively (F=0.092, р=0.016; F=0.107, р=0,007, respectively). At the baseline, the groups had similar results of the vaginal discharge culture tests. In the group 1 patients, Candida spp. were not identified at any of the endpoints, in group 2 — Candida spp. were found in 22.5% of patients, starting from day 13 (F=0,125, р=0,002). No adverse events were reported. Conclusion: the administration of Ecofucin® vaginal suppositories containing natamycin 100 mg and excipient lactulose is effective for preventing microbiota dysbiosis — bacterial vaginosis and candidiasis in patients receiving antimicrobial therapy. KEYWORDS: vagina, microbiocenosis, antimicrobial therapy, lactobacilli, bifidobacteria, candidiasis, natamycin, lactulose. FOR CITATION: Kuzmin V.N. Ecofucin® for the prevention of vaginal microbiota dysbiosis — bacterial vaginosis and candidiasis amid the use of systemic antimicrobial therapy. Russian Journal of Woman and Child Health. 2022;5(4):292–296 (in Russ.). DOI: 10.32364/2618-8430- 2022-5-4-292-296.
目的:评估Ecofucin®在计划妇科手术后患者在使用全身抗菌药物治疗(AMT)期间阴道微生物群随时间变化的有效性和安全性。患者和方法:这项前瞻性、开放、随机、比较平行组临床研究纳入了无阴道菌群失调症状(细菌性阴道病或念珠菌病)的患者，这些患者住院接受计划的手术治疗。组1患者(n=39)接受全身AMT和Ecofucin®阴道内应用，每天1次，睡前12天，从计划手术和AMT开始前6天开始，而组2患者(n=40)仅接受全身AMT。在AMT完成并使用被试药物后第1天(即开始应用Ecofucin后第13天)和开始使用被试药物后30±2天评估疗效。采用临床、微生物学和分子遗传学方法进行评估。结果:在AMT开始后的第13天和第30±2天，18%和21%的2组患者报告了阴道微生物群失调的常见症状-细菌性阴道病和念珠菌病，而1组患者未记录此类症状(F=0,107, r =0,007)。在100%的1组患者中，在所有终点均检测到乳酸菌和双歧杆菌。2组患者在第13天和第30±2天分别有93.8%和97%的患者检出乳酸菌(F=0.035, p=0.2;F=0.017, p=0.458)，双歧杆菌-分别占84.4%和81.1% (F=0.092, p= 0.016;F=0.107, r =0,007)。在基线时，两组的阴道分泌物培养测试结果相似。在1组患者中，在任何终点均未检出念珠菌，在2组患者中，从第13天开始，22.5%的患者中检出念珠菌(F=0,125, r =0,002)。无不良事件报告。结论:Ecofucin阴道栓剂(含纳他霉素100 mg)和辅料乳果糖可有效预防抗菌药物治疗患者的菌群失调-细菌性阴道病和念珠菌病。关键词:阴道，微生物病，抗菌治疗，乳酸菌，双歧杆菌，念珠菌病，那他霉素，乳果糖。Ecofucin®用于预防阴道微生物群失调-细菌性阴道病和念珠菌病在使用全身抗菌治疗。俄罗斯妇女与儿童健康杂志，2022;5(4):292-296。Doi: 10.32364/2618-8430- 2022-5-4-292-296。
{"title":"Ecofucin® for the prevention of vaginal microbiota dysbiosis — bacterial vaginosis and candidiasis amid the use of systemic antimicrobial therapy","authors":"V. Kuzmin","doi":"10.32364/2618-8430-2022-5-4-292-296","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-292-296","url":null,"abstract":"Aim: to assess the efficacy and safety of Ecofucin® in patients after performing planned gynecologic surgery procedures based on the changes in vaginal microbiota over time amid the use of systemic antimicrobial therapy (AMT). Patients and Methods: this prospective open randomized comparative parallel-group clinical study involved patients without signs of vaginal microbiota dysbiosis — bacterial vaginosis or candidiasis, who were hospitalized for planned surgery procedures. The group 1 patients (n=39) received systemic AMT and Ecofucin® for intravaginal application once a day at the bedtime for 12 days, starting 6 days before the planned surgery and AMT initiation, while the group 2 patients (n=40) received only systemic AMT. The efficacy was assessed a day after the completion of AMT and the use of the tested medication (i.e. on day 13 after the initiation of Ecofucin application) and 30±2 days after the initiation of using the tested drug. Clinical, microbiological and molecular genetic methods were used for the assessment. Results: symptoms common for vaginal microbiota dysbiosis — bacterial vaginosis and candidiasis were reported by 18% and 21% of the group 2 patients at days 13 and 30±2 after the initiation of AMT, while such symptoms were not recorded in any of the group 1 patients (F=0,107, р=0,007). In 100% of the group 1 patients both lactobacilli and bifidobacteria were detected at all endpoints. In group 2, lactobacilli were found at days 13 and 30±2 in 93.8% and 97% of patients, respectively (F=0.035, p=0.2; F=0.017, p=0.458), bifidobacteria — in 84.4% and 81.1% of patients, respectively (F=0.092, р=0.016; F=0.107, р=0,007, respectively). At the baseline, the groups had similar results of the vaginal discharge culture tests. In the group 1 patients, Candida spp. were not identified at any of the endpoints, in group 2 — Candida spp. were found in 22.5% of patients, starting from day 13 (F=0,125, р=0,002). No adverse events were reported. Conclusion: the administration of Ecofucin® vaginal suppositories containing natamycin 100 mg and excipient lactulose is effective for preventing microbiota dysbiosis — bacterial vaginosis and candidiasis in patients receiving antimicrobial therapy. KEYWORDS: vagina, microbiocenosis, antimicrobial therapy, lactobacilli, bifidobacteria, candidiasis, natamycin, lactulose. FOR CITATION: Kuzmin V.N. Ecofucin® for the prevention of vaginal microbiota dysbiosis — bacterial vaginosis and candidiasis amid the use of systemic antimicrobial therapy. Russian Journal of Woman and Child Health. 2022;5(4):292–296 (in Russ.). DOI: 10.32364/2618-8430- 2022-5-4-292-296.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-118-121
L. V. Saprykina, M. R. Narimanova, D. M. Ibragimova
Background: polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 10% of women of reproductive age. Combined oral contraceptive pills (COCP) are effective in PCOS. Drospirenone is a new progestin with properties similar to natural progesterone (including anti-mineralocorticoid and antiandrogenic activities). Aim: to evaluate the effect of drospirenone-containing COCP (20 μg ethinylestradiol and 3 mg drospirenone) on anthropometric and sonographic characteristics, and carbohydrate metabolism parameters in women with PCOS. Patients and Methods: this prospective study enrolled 22 women of reproductive age (mean age 22.1±0.5 years) with PCOS. All females were treated during six cycles (28 days each). At baseline and 6 months after starting treatment, anthropometric (body mass index/BMI, waist-to- hip ratio/WHR) and sonographic (ovary volume) characteristics, and carbohydrate metabolism parameters (plasma insulin, fasting glucose, homeostasis model assessment of insulin resistance/HOMA-IR) were assessed. Results: 6 months after starting treatment, a significant (p<0.05) reduction in BMI (from 22.54±0.43 kg/m2 to 20.86±0.26 kg/m2), WHR (from 0.81±0.01 to 0.78±0.01), and ovary volume (left ovary: from 12.75±0.43 cm3 to 8.05±0.15 cm3; right ovary: from 13.0±0.54 cm3 to 8.63±0.14 cm3) was reported. Meanwhile, no significant (р>0.05) changes in plasma insulin concentration (9.91±0.42 μU/ml vs. 9.52±0.31 μU/ml), fasting blood glucose (4.95±0.08 mmol/l vs. 4.9±0.07 mmol/l), and HOMA-IR (3.2±1.12 vs. 3.06±0.07) compared to baseline levels were reported. The most common side effects were headache or dizziness (n=3, 13.6%), nausea (n=2, 9.1%) and irregular bleeding (n=3, 13.6%). Conclusion: drospirenone-containing COCP has a beneficial effect on anthropometric paramaters and ovary volume but does not affect carbohydrate metabolism. This drug is characterized by excellent compliance. KEYWORDS: polycystic ovary syndrome, drospirenone, body mass index, waist-hip ratio, reproductive age, ovary volume, glucose, insulin, carbohydrates, HOMA-IR. FOR CITATION: Saprykina L.V., Narimanova M.R., Ibragimova D.M. Effect of drospirenone-containing combined oral contraceptive pills on anthropometric and sonographic characteristics and carbohydrate metabolism parameters in women with polycystic ovary syndrome. Russian Journal of Woman and Child Health. 2022;5(2):118–121 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-118-121.
背景:多囊卵巢综合征(PCOS)是一种影响10%育龄妇女的内分泌疾病。复方口服避孕药(COCP)对多囊卵巢综合征(PCOS)有效。屈螺酮是一种新型黄体酮，具有与天然黄体酮相似的特性(包括抗矿化皮质激素和抗雄激素活性)。目的:评价含屈螺酮COCP (20 μg炔雌醇加3 mg屈螺酮)对PCOS女性人体测量、超声特征及碳水化合物代谢参数的影响。患者和方法:本前瞻性研究纳入22名育龄妇女(平均年龄22.1±0.5岁)多囊卵巢综合征。所有的雌性在6个周期(每个28天)内治疗。在基线和开始治疗后6个月，评估人体测量(体重指数/BMI，腰臀比/WHR)和超声(卵巢体积)特征，以及碳水化合物代谢参数(血浆胰岛素，空腹血糖，胰岛素抵抗的稳态模型评估/HOMA-IR)。结果:开始治疗6个月后，血浆胰岛素浓度(9.91±0.42 μU/ml vs. 9.52±0.31 μU/ml)、空腹血糖(4.95±0.08 mmol/l vs. 4.9±0.07 mmol/l)、HOMA-IR(3.2±1.12 vs. 3.06±0.07)与基线水平相比有显著(p0.05)变化。最常见的副作用是头痛或头晕(n=3, 13.6%)、恶心(n=2, 9.1%)和不规则出血(n=3, 13.6%)。结论:含螺螺酮的COCP对人体测量参数和卵巢体积有有益影响，但不影响碳水化合物代谢。该药的特点是极好的顺应性。关键词:多囊卵巢综合征、降螺酮、体重指数、腰臀比、生育年龄、卵巢体积、葡萄糖、胰岛素、碳水化合物、HOMA-IR。引用本文:Saprykina l.v.， Narimanova m.r.， Ibragimova D.M.含多螺旋酮联合口服避孕药对多囊卵巢综合征女性人体测量、超声特征及碳水化合物代谢参数的影响。俄罗斯妇幼卫生杂志，2022;5(2):118-121。DOI: 10.32364 / 2618-8430-2022-5-2-118-121。
{"title":"Effect of drospirenone-containing combined oral contraceptive pills on anthropometric and sonographic characteristics and carbohydrate metabolism parameters in women with polycystic ovary syndrome","authors":"L. V. Saprykina, M. R. Narimanova, D. M. Ibragimova","doi":"10.32364/2618-8430-2022-5-2-118-121","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-118-121","url":null,"abstract":"Background: polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 10% of women of reproductive age. Combined oral contraceptive pills (COCP) are effective in PCOS. Drospirenone is a new progestin with properties similar to natural progesterone (including anti-mineralocorticoid and antiandrogenic activities). Aim: to evaluate the effect of drospirenone-containing COCP (20 μg ethinylestradiol and 3 mg drospirenone) on anthropometric and sonographic characteristics, and carbohydrate metabolism parameters in women with PCOS. Patients and Methods: this prospective study enrolled 22 women of reproductive age (mean age 22.1±0.5 years) with PCOS. All females were treated during six cycles (28 days each). At baseline and 6 months after starting treatment, anthropometric (body mass index/BMI, waist-to- hip ratio/WHR) and sonographic (ovary volume) characteristics, and carbohydrate metabolism parameters (plasma insulin, fasting glucose, homeostasis model assessment of insulin resistance/HOMA-IR) were assessed. Results: 6 months after starting treatment, a significant (p<0.05) reduction in BMI (from 22.54±0.43 kg/m2 to 20.86±0.26 kg/m2), WHR (from 0.81±0.01 to 0.78±0.01), and ovary volume (left ovary: from 12.75±0.43 cm3 to 8.05±0.15 cm3; right ovary: from 13.0±0.54 cm3 to 8.63±0.14 cm3) was reported. Meanwhile, no significant (р>0.05) changes in plasma insulin concentration (9.91±0.42 μU/ml vs. 9.52±0.31 μU/ml), fasting blood glucose (4.95±0.08 mmol/l vs. 4.9±0.07 mmol/l), and HOMA-IR (3.2±1.12 vs. 3.06±0.07) compared to baseline levels were reported. The most common side effects were headache or dizziness (n=3, 13.6%), nausea (n=2, 9.1%) and irregular bleeding (n=3, 13.6%). Conclusion: drospirenone-containing COCP has a beneficial effect on anthropometric paramaters and ovary volume but does not affect carbohydrate metabolism. This drug is characterized by excellent compliance. KEYWORDS: polycystic ovary syndrome, drospirenone, body mass index, waist-hip ratio, reproductive age, ovary volume, glucose, insulin, carbohydrates, HOMA-IR. FOR CITATION: Saprykina L.V., Narimanova M.R., Ibragimova D.M. Effect of drospirenone-containing combined oral contraceptive pills on anthropometric and sonographic characteristics and carbohydrate metabolism parameters in women with polycystic ovary syndrome. Russian Journal of Woman and Child Health. 2022;5(2):118–121 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-118-121.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-157-163
I. Alexandrova, M.V. Ayzatova
Aim: to provide a physiological hygienic basis and regulation for using interactive panels (IP) in class to ensure safe learning in the digital environment. Patients and Methods: the following goals were set: (1) to compare the effects of interactive panels versus school board on the functional state of the body (FSB) of schoolchildren; (2) to analyze FSB of schoolchildren after classes with various duration of IP use. FSB of schoolchildren (mental and visual performance) in classes with the use of IPs (experimental class, n=28) or a classic chalk board (control class, n=26) were compared. A complex of hygienic, physiological, and statistical methods was applied. Results: based on a comparative analysis of mental capacity (MC) indicators of two classes, the tendency of lessons with the use of IPs showed the obvious and excessive fatigue more commonly registered among first-grade pupils (p<0.05), and the number of characters viewed in tests was decreased. The integral performance indicator of the class team changed more significantly after lessons with the use of IPs, reflecting the prevalence of "unsatisfactory" and "poor" proportions of performed proofreading tests over the number of "excellent" and "good". The specified indicator in the experimental class, being twice as high at the beginning of the school day, became 2 times lower by the end of classes versus the control class. The decrease in the parameters of the critical flicker fusion frequency (CFFF), indicating a deterioration in the functional state of the visual system, was more noticeable in the experimental class (p<0.01). The analysis of the average weekly MC indicators also revealed that the control class made fewer mistakes in the tests, they had significantly fewer signs of obvious and excessive fatigue. Conclusion: schoolchildren with unregulated use of IPs (versus the control class equipped with the classic chalk board) commonly had adverse indicators of mental and visual performance. The permissible time for the use of IPs during the lesson was justified, the excess of which leads to a significantly more negative trend among children’s FSB indicators. KEYWORDS: prevention, schoolchildren, hygienic regulations, excessive fatigue, interactive panels. FOR CITATION: Alexandrova I.E., Ayzatova M.V. Functional state of the body of elementary schoolchildren when using e-learning tools. Russian Journal of Woman and Child Health. 2022;5(2):157–163 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-157-163.
{"title":"Functional state of the body of elementary schoolchildren when using e-learning tools","authors":"I. Alexandrova, M.V. Ayzatova","doi":"10.32364/2618-8430-2022-5-2-157-163","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-157-163","url":null,"abstract":"Aim: to provide a physiological hygienic basis and regulation for using interactive panels (IP) in class to ensure safe learning in the digital environment. Patients and Methods: the following goals were set: (1) to compare the effects of interactive panels versus school board on the functional state of the body (FSB) of schoolchildren; (2) to analyze FSB of schoolchildren after classes with various duration of IP use. FSB of schoolchildren (mental and visual performance) in classes with the use of IPs (experimental class, n=28) or a classic chalk board (control class, n=26) were compared. A complex of hygienic, physiological, and statistical methods was applied. Results: based on a comparative analysis of mental capacity (MC) indicators of two classes, the tendency of lessons with the use of IPs showed the obvious and excessive fatigue more commonly registered among first-grade pupils (p<0.05), and the number of characters viewed in tests was decreased. The integral performance indicator of the class team changed more significantly after lessons with the use of IPs, reflecting the prevalence of \"unsatisfactory\" and \"poor\" proportions of performed proofreading tests over the number of \"excellent\" and \"good\". The specified indicator in the experimental class, being twice as high at the beginning of the school day, became 2 times lower by the end of classes versus the control class. The decrease in the parameters of the critical flicker fusion frequency (CFFF), indicating a deterioration in the functional state of the visual system, was more noticeable in the experimental class (p<0.01). The analysis of the average weekly MC indicators also revealed that the control class made fewer mistakes in the tests, they had significantly fewer signs of obvious and excessive fatigue. Conclusion: schoolchildren with unregulated use of IPs (versus the control class equipped with the classic chalk board) commonly had adverse indicators of mental and visual performance. The permissible time for the use of IPs during the lesson was justified, the excess of which leads to a significantly more negative trend among children’s FSB indicators. KEYWORDS: prevention, schoolchildren, hygienic regulations, excessive fatigue, interactive panels. FOR CITATION: Alexandrova I.E., Ayzatova M.V. Functional state of the body of elementary schoolchildren when using e-learning tools. Russian Journal of Woman and Child Health. 2022;5(2):157–163 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-157-163.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-164-168
V. V. Platonov, T. A. Dubinina, E. Patrakeeva, Alexander P Rezvykh, N. V. Kazachenko
Aim: to assess the potential effect of switching from original insulins (lispro and glargine) to Russian biosimilars on glycemic control in adolescents with type 1 diabetes (T1D). Patients and Methods: this 24-week observational clinical trial enrolled 24 adolescents with T1D aged 12–15 (mean age 13.4±1.1 years), 13 boys (54.2%, mean age 13.1±1.1 years) and 11 girls (45.8%, mean age 13.0±0.9 years). Disease duration was 4.0±1.1 years in boys and 4.3±1.8 years in girls. Insulin therapy included original multiple daily injections (MDI) of insulins lispro and glargine. Patients were switched to biosimilars at a ratio of 1:1, doses were adjusted by the patients themselves. Blood sugar levels were measured by flash glucose monitoring (FGM). Time in the target range (TIR), time above the target range (TAR), time below the target range (TBR), and glycated hemoglobin (HbA1c) in the original insulin therapy and 3 and 6 months after switching to Russian biosimilars were evaluated. Results: three and six months after switching of T1D adolescents to Russian biosimilars, no clinically significant worsening of glycemic control parameters was reported, i.e., HbA1c (3 months) 7.6±1.1%, HbA1c (6 months) 7.5±0.9% (p>0.05), TIR (3 months) 65.1±10.6%, TIR (6 months) 66.5±10.7% (р>0.05), TAR (3 months) 26.8±10.9%, TAR (6 months) 25.5±11.1% (p>0.05), TBR (3 months) 8.1±4.3%, TBR (6 months) 7.9±4.5% (p>0,05). No significant differences in the parameters studied between boys and girls 3 and 6 months after therapy switching were reported. No significant changes in the total daily Insulin dose (TDI) were reported, i.e., TDI (3 months) 1.4±0.3 U/kg, TDI (6 months) 1.3±0.3 U/kg. Conclusion: Russian biosimilars of insulins lispro and glargine for T1D in adolescents are not associated with either an increase in TDI or worsening of glycemic control parameters, e.g., HbA1c, TIR, TAR, and TBR. KEYWORDS: type 1 diabetes, insulin, biosimilars, lispro, glargine, glycated hemoglobin, glycemic control, time in the range. FOR CITATION: Platonov V.V., Dubinina T.A., Patrakeeva E.M. et al. Efficacy of Russian insulin biosimilars for type 1 diabetes in adolescents. Russian Journal of Woman and Child Health. 2022;5(2):165–168 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-165-168.
{"title":"Efficacy of Russian insulin biosimilars for type 1 diabetes in adolescents","authors":"V. V. Platonov, T. A. Dubinina, E. Patrakeeva, Alexander P Rezvykh, N. V. Kazachenko","doi":"10.32364/2618-8430-2022-5-2-164-168","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-164-168","url":null,"abstract":"Aim: to assess the potential effect of switching from original insulins (lispro and glargine) to Russian biosimilars on glycemic control in adolescents with type 1 diabetes (T1D). Patients and Methods: this 24-week observational clinical trial enrolled 24 adolescents with T1D aged 12–15 (mean age 13.4±1.1 years), 13 boys (54.2%, mean age 13.1±1.1 years) and 11 girls (45.8%, mean age 13.0±0.9 years). Disease duration was 4.0±1.1 years in boys and 4.3±1.8 years in girls. Insulin therapy included original multiple daily injections (MDI) of insulins lispro and glargine. Patients were switched to biosimilars at a ratio of 1:1, doses were adjusted by the patients themselves. Blood sugar levels were measured by flash glucose monitoring (FGM). Time in the target range (TIR), time above the target range (TAR), time below the target range (TBR), and glycated hemoglobin (HbA1c) in the original insulin therapy and 3 and 6 months after switching to Russian biosimilars were evaluated. Results: three and six months after switching of T1D adolescents to Russian biosimilars, no clinically significant worsening of glycemic control parameters was reported, i.e., HbA1c (3 months) 7.6±1.1%, HbA1c (6 months) 7.5±0.9% (p>0.05), TIR (3 months) 65.1±10.6%, TIR (6 months) 66.5±10.7% (р>0.05), TAR (3 months) 26.8±10.9%, TAR (6 months) 25.5±11.1% (p>0.05), TBR (3 months) 8.1±4.3%, TBR (6 months) 7.9±4.5% (p>0,05). No significant differences in the parameters studied between boys and girls 3 and 6 months after therapy switching were reported. No significant changes in the total daily Insulin dose (TDI) were reported, i.e., TDI (3 months) 1.4±0.3 U/kg, TDI (6 months) 1.3±0.3 U/kg. Conclusion: Russian biosimilars of insulins lispro and glargine for T1D in adolescents are not associated with either an increase in TDI or worsening of glycemic control parameters, e.g., HbA1c, TIR, TAR, and TBR. KEYWORDS: type 1 diabetes, insulin, biosimilars, lispro, glargine, glycated hemoglobin, glycemic control, time in the range. FOR CITATION: Platonov V.V., Dubinina T.A., Patrakeeva E.M. et al. Efficacy of Russian insulin biosimilars for type 1 diabetes in adolescents. Russian Journal of Woman and Child Health. 2022;5(2):165–168 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-165-168.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-287-291
I. Tihonenko
Aim: to assess the outcomes of prenatally diagnosed ovarian cysts and to identify ultrasound features associated with the prognosis of surgical treatment Patients and Methods: this retrospective study evaluated 59 fetal ovarian cysts diagnosed during ultrasound screening in the prenatal ultrasound center. The following parameters were reviewed: parity, maternal age, time of prenatal diagnosis, ultrasound cystic features and structure, and the outcomes of fetal ovarian cysts. Results: fetal ovarian cysts were detected during pregnancy in women with a median age of 30.6 years (17–42 years), 40.7% of them were primipara. A median gestational age at the date of prenatal cyst diagnosis was 33.5 (21.2–38) weeks of pregnancy. In 25.4% of cases the ovarian cysts had complex echotexture, and in 33.2% of cases a cyst diameter was ≥40 mm. In 32.2% of cases, the cysts were located at some distance from the bladder; 39% of the cysts were fully or partially visualized in the abdomen. The spontaneous cyst resolution by the time of delivery was reported in 37.3% of cases, including 40% of complex cysts. After birth, 35.6% of ovarian cysts disappeared and 20% of complex cysts demonstrated regression. Also, the regression occurred in 26.3% of cysts ≥ 40 mm. Overall, spontaneous resolution was reported for 60% of complex cysts, 42.1% of cysts ≥40 mm, 52.6% of cysts distinct from the bladder and 56.5% of cysts located in the abdomen. Postnatal surgery was performed in 27.1% of the newborn girls. The likelihood of surgical treatment was higher in the newborns with prenatal cysts ≥ 40 mm comparing to cysts < 40 mm (odds ratio (OR), 7.78 (95% confidence interval (CI), 2.12–28.53)) and cysts located in the abdomen comparing to cysts located in the fetal pelvis (OR, 16.25 (95% CI, 3.84–68.82)). No correlation was found between ultrasound features of ovarian cysts and torsion Conclusion: the ultrasound features of prenatally diagnosed ovarian cysts which are important for predicting a higher risk of postnatal surgical procedures include the cyst diameter (≥ 40 mm) and the location (especially in the abdomen). These factors should be taken into consideration for choosing a maternity hospital and prenatal consulting of parents. KEYWORDS: fetal ovarian cyst, prenatal diagnosis, ultrasound features, outcome, prognosis. FOR CITATION: Tihonenko I.V. Ultrasound features of prenatally diagnosed ovarian cysts: what is important for the prognosis. Russian Journal of Woman and Child Health. 2022;5(4):287–291 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-287-291.
{"title":"Ultrasound features of prenatally diagnosed ovarian cysts: what is important for the prognosis","authors":"I. Tihonenko","doi":"10.32364/2618-8430-2022-5-4-287-291","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-287-291","url":null,"abstract":"Aim: to assess the outcomes of prenatally diagnosed ovarian cysts and to identify ultrasound features associated with the prognosis of surgical treatment Patients and Methods: this retrospective study evaluated 59 fetal ovarian cysts diagnosed during ultrasound screening in the prenatal ultrasound center. The following parameters were reviewed: parity, maternal age, time of prenatal diagnosis, ultrasound cystic features and structure, and the outcomes of fetal ovarian cysts. Results: fetal ovarian cysts were detected during pregnancy in women with a median age of 30.6 years (17–42 years), 40.7% of them were primipara. A median gestational age at the date of prenatal cyst diagnosis was 33.5 (21.2–38) weeks of pregnancy. In 25.4% of cases the ovarian cysts had complex echotexture, and in 33.2% of cases a cyst diameter was ≥40 mm. In 32.2% of cases, the cysts were located at some distance from the bladder; 39% of the cysts were fully or partially visualized in the abdomen. The spontaneous cyst resolution by the time of delivery was reported in 37.3% of cases, including 40% of complex cysts. After birth, 35.6% of ovarian cysts disappeared and 20% of complex cysts demonstrated regression. Also, the regression occurred in 26.3% of cysts ≥ 40 mm. Overall, spontaneous resolution was reported for 60% of complex cysts, 42.1% of cysts ≥40 mm, 52.6% of cysts distinct from the bladder and 56.5% of cysts located in the abdomen. Postnatal surgery was performed in 27.1% of the newborn girls. The likelihood of surgical treatment was higher in the newborns with prenatal cysts ≥ 40 mm comparing to cysts < 40 mm (odds ratio (OR), 7.78 (95% confidence interval (CI), 2.12–28.53)) and cysts located in the abdomen comparing to cysts located in the fetal pelvis (OR, 16.25 (95% CI, 3.84–68.82)). No correlation was found between ultrasound features of ovarian cysts and torsion Conclusion: the ultrasound features of prenatally diagnosed ovarian cysts which are important for predicting a higher risk of postnatal surgical procedures include the cyst diameter (≥ 40 mm) and the location (especially in the abdomen). These factors should be taken into consideration for choosing a maternity hospital and prenatal consulting of parents. KEYWORDS: fetal ovarian cyst, prenatal diagnosis, ultrasound features, outcome, prognosis. FOR CITATION: Tihonenko I.V. Ultrasound features of prenatally diagnosed ovarian cysts: what is important for the prognosis. Russian Journal of Woman and Child Health. 2022;5(4):287–291 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-287-291.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-11-17
N. A. Nashivochnikova, V. Krupin, S. Zubova, V. E. Leanovich
Aim: to assess the effect of "Pregnoton" food supplement on pelvic venous hemodynamics in women with pelvic congestion syndrome, risk of urogenital infection recurrences during preparing for pregnancy, and sperm motility in the female genital tract. Patients and Methods: the study enrolled 87 women with recurrent cystitis (disease duration 1–5 years) secondary to pelvic congestion syndrome. Sixty-two women received "Pregnoton" to improve pelvic venous tone and prevent detrusor muscle ischemia. Later, pregnancy occurred in 20 women included in the study group. The control group included 25 women with recurrent cystitis secondary to pelvic congestion syndrome who did not receive "Pregnoton". Sperm motility was evaluated by postcoital test. In addition, pain severity, chronic cystitis recurrence rate, and pelvic venous hemodynamics were assessed. Results: women who received "Pregnoton" reported significant pain reduction during the pregnancy (from 6.3 to 3.1 points by pain scale) compared to control group women who reported more severe pain (from 5.8 to 7.8 points). In addition, improvement of pelvic venous hemodynamics (associated with further reduction in inflammation of the lower urinary tract) was detected in the study group. The therapeutic efficacy of preparation for pregnancy in women with recurrent cystitis secondary to pelvic congestion syndrome was 90% in the study group. Exacerbations of chronic cystitis were identified in two women (10%) of the study group and ten women (40%) of the control group. Conclusion: preparation for pregnancy in women with chronic recurrent cystitis and pelvic congestion syndrome using complex "Pregnoton" improves hemodynamics, lab test results, and clinical signs of bladder inflammation and reduces pain severity. KEYWORDS: food supplement, pelvic congestion syndrome, cystitis, preparation for pregnancy, treatment. FOR CITATION: Nashivochnikova N.A., Krupin V.N., Zubova S.Yu., Leanovich V.E. Complex preparation for pregnancy of women with chronic recurrent cystitis and pelvic congestion syndrome. Russian Journal of Woman and Child Health. 2022;5(1):11–17 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-11-17.
{"title":"Complex preparation for pregnancy of women with chronic recurrent cystitis and pelvic congestion syndrome","authors":"N. A. Nashivochnikova, V. Krupin, S. Zubova, V. E. Leanovich","doi":"10.32364/2618-8430-2022-5-1-11-17","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-11-17","url":null,"abstract":"Aim: to assess the effect of \"Pregnoton\" food supplement on pelvic venous hemodynamics in women with pelvic congestion syndrome, risk of urogenital infection recurrences during preparing for pregnancy, and sperm motility in the female genital tract. Patients and Methods: the study enrolled 87 women with recurrent cystitis (disease duration 1–5 years) secondary to pelvic congestion syndrome. Sixty-two women received \"Pregnoton\" to improve pelvic venous tone and prevent detrusor muscle ischemia. Later, pregnancy occurred in 20 women included in the study group. The control group included 25 women with recurrent cystitis secondary to pelvic congestion syndrome who did not receive \"Pregnoton\". Sperm motility was evaluated by postcoital test. In addition, pain severity, chronic cystitis recurrence rate, and pelvic venous hemodynamics were assessed. Results: women who received \"Pregnoton\" reported significant pain reduction during the pregnancy (from 6.3 to 3.1 points by pain scale) compared to control group women who reported more severe pain (from 5.8 to 7.8 points). In addition, improvement of pelvic venous hemodynamics (associated with further reduction in inflammation of the lower urinary tract) was detected in the study group. The therapeutic efficacy of preparation for pregnancy in women with recurrent cystitis secondary to pelvic congestion syndrome was 90% in the study group. Exacerbations of chronic cystitis were identified in two women (10%) of the study group and ten women (40%) of the control group. Conclusion: preparation for pregnancy in women with chronic recurrent cystitis and pelvic congestion syndrome using complex \"Pregnoton\" improves hemodynamics, lab test results, and clinical signs of bladder inflammation and reduces pain severity. KEYWORDS: food supplement, pelvic congestion syndrome, cystitis, preparation for pregnancy, treatment. FOR CITATION: Nashivochnikova N.A., Krupin V.N., Zubova S.Yu., Leanovich V.E. Complex preparation for pregnancy of women with chronic recurrent cystitis and pelvic congestion syndrome. Russian Journal of Woman and Child Health. 2022;5(1):11–17 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-11-17.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69548131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-237-243
D. Usenko
Acute otitis media (AOM) is one of the most common diseases in children and adults, as well as the most frequent reasons for prescribing antibacterial therapy (routinely unjustified). The review presents data on the incidence of AOM among the child population in the Russian Federation, discusses the most common viral and bacterial disease pathogens. The review also introduces the term "orthotropic" viral pathogens capable of causing the AOM development with a higher probability. The review discusses the role of microbiota in the AOM development, the difficulties of diagnosis and AOM in children. It also considers the issues of AOM treatment in detail. In clinical practice, preference is given to the combination of lidocaine + phenazone due to the broad evidence base and long-term experience. The recommendation to use topical analgesic drugs as the first-line therapy in AOM during the pre-perforation period of the disease allows to implement a watchful waiting regarding the use of antibacterial drugs, as well as to avoid adverse events of systemic NSAIDs, such as gastrointestinal disorders and nausea. The review focuses on the use of antibiotic therapy in the treatment of AOM. Rational treatment tactics of AOM allows to avoid the development of complications and the inconsistent use of antimicrobials, which will help to prevent bacterial colonization in the nasopharynx and tympanic cavity, as well as the antibiotic resistance development. KEYWORDS: acute otitis media, inflammatory diseases, otopathogen, lidocaine, phenazone, NSAIDs, antibiotic therapy. FOR CITATION: Usenko D.V. Rational therapy of acute otitis media in children based on evidence-based medicine. Russian Journal of Woman and Child Health. 2022;5(3):237–243 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-237-243.
{"title":"Rational therapy of acute otitis media in children based on evidence-based medicine","authors":"D. Usenko","doi":"10.32364/2618-8430-2022-5-3-237-243","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-237-243","url":null,"abstract":"Acute otitis media (AOM) is one of the most common diseases in children and adults, as well as the most frequent reasons for prescribing antibacterial therapy (routinely unjustified). The review presents data on the incidence of AOM among the child population in the Russian Federation, discusses the most common viral and bacterial disease pathogens. The review also introduces the term \"orthotropic\" viral pathogens capable of causing the AOM development with a higher probability. The review discusses the role of microbiota in the AOM development, the difficulties of diagnosis and AOM in children. It also considers the issues of AOM treatment in detail. In clinical practice, preference is given to the combination of lidocaine + phenazone due to the broad evidence base and long-term experience. The recommendation to use topical analgesic drugs as the first-line therapy in AOM during the pre-perforation period of the disease allows to implement a watchful waiting regarding the use of antibacterial drugs, as well as to avoid adverse events of systemic NSAIDs, such as gastrointestinal disorders and nausea. The review focuses on the use of antibiotic therapy in the treatment of AOM. Rational treatment tactics of AOM allows to avoid the development of complications and the inconsistent use of antimicrobials, which will help to prevent bacterial colonization in the nasopharynx and tympanic cavity, as well as the antibiotic resistance development. KEYWORDS: acute otitis media, inflammatory diseases, otopathogen, lidocaine, phenazone, NSAIDs, antibiotic therapy. FOR CITATION: Usenko D.V. Rational therapy of acute otitis media in children based on evidence-based medicine. Russian Journal of Woman and Child Health. 2022;5(3):237–243 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-237-243.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69550350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-366-372
L. Balykova, M. Shirmankina, D. Vladimirov, E. I. Naumenko, E. Samoshkina, R. A. Chernyshova
Post-COVID-19 syndrome is an important challenge for modern medicine, requiring the involvement of different health professionals. This multidisciplinary approach is underpinned by the variety of clinical manifestations and the need for comprehensive rehabilitation of patients, including children and adolescents. The review highlights clinical manifestations of post-COVID-19 syndrome. Currently, a symptom management approach has been established for improving post-COVID-19 conditions. Also, appropriate lifestyle changes, such as adequate rest and sleep hygiene, may be useful. Rehabilitation interventions for post-COVID-19 syndrome may include physiotherapy exercises and various psychotherapy techniques. Since mitochondrial dysfunction, energy supply deficit, oxidative stress, endothelial dysfunction, and immune dysregulation profoundly impact the pathogenesis of post-COVID-19 syndrome, the use of L-carnitine which plays a crucial role in energy production, is considered as a promising method in the management of such patients. L-carnitine may have cardioprotective, anabolic and neuroprotective effects. The authors present a case report of post-COVID-19 condition in their own patient, a 4-year-old boy who survived multisystem inflammatory syndrome. As a result of combination therapy, including L-carnitine, the patient’s sense of well-being significantly improved: he had no complaints, the muscle weakness and asthenization became less pronounced, and his spirits rose. The described clinical case illustrated the effectiveness of using L-carnitine in the combined therapy of post-COVID-19 syndrome in children KEYWORDS: COVID-19, post-COVID syndrome, multisystem inflammatory syndrome, L-carnitine, children, rehabilitation, asthenization, anxiety disorder FOR CITATION: Balykova L.A., Shirmankina M.V., Vladimirov D.O. et al. Post-COVID syndrome in children and adolescents: a literature review and clinical case. Russian Journal of Woman and Child Health. 2022;5(4):366–372 (in Russ.). DOI: 10.32364/2618-8430-2022- 5-4-366-372.
{"title":"Post-COVID syndrome in children and adolescents: a literature review and clinical case","authors":"L. Balykova, M. Shirmankina, D. Vladimirov, E. I. Naumenko, E. Samoshkina, R. A. Chernyshova","doi":"10.32364/2618-8430-2022-5-4-366-372","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-366-372","url":null,"abstract":"Post-COVID-19 syndrome is an important challenge for modern medicine, requiring the involvement of different health professionals. This multidisciplinary approach is underpinned by the variety of clinical manifestations and the need for comprehensive rehabilitation of patients, including children and adolescents. The review highlights clinical manifestations of post-COVID-19 syndrome. Currently, a symptom management approach has been established for improving post-COVID-19 conditions. Also, appropriate lifestyle changes, such as adequate rest and sleep hygiene, may be useful. Rehabilitation interventions for post-COVID-19 syndrome may include physiotherapy exercises and various psychotherapy techniques. Since mitochondrial dysfunction, energy supply deficit, oxidative stress, endothelial dysfunction, and immune dysregulation profoundly impact the pathogenesis of post-COVID-19 syndrome, the use of L-carnitine which plays a crucial role in energy production, is considered as a promising method in the management of such patients. L-carnitine may have cardioprotective, anabolic and neuroprotective effects. The authors present a case report of post-COVID-19 condition in their own patient, a 4-year-old boy who survived multisystem inflammatory syndrome. As a result of combination therapy, including L-carnitine, the patient’s sense of well-being significantly improved: he had no complaints, the muscle weakness and asthenization became less pronounced, and his spirits rose. The described clinical case illustrated the effectiveness of using L-carnitine in the combined therapy of post-COVID-19 syndrome in children KEYWORDS: COVID-19, post-COVID syndrome, multisystem inflammatory syndrome, L-carnitine, children, rehabilitation, asthenization, anxiety disorder FOR CITATION: Balykova L.A., Shirmankina M.V., Vladimirov D.O. et al. Post-COVID syndrome in children and adolescents: a literature review and clinical case. Russian Journal of Woman and Child Health. 2022;5(4):366–372 (in Russ.). DOI: 10.32364/2618-8430-2022- 5-4-366-372.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69551087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-346-350
V. Kotlyarov, M.A. Kalinina, G.V. Kozlovskaya, G.N. Shimonova
The article presents a short literature review highlighting a potential genesis of the disease and genetic background of congenital connective tissue dysplasia, as well as its association with certain congenital biochemical and mediator abnormalities. Over the past years, there has been a substantial growth of publications discussing a close relationship between connective tissue diseases and psychic deviations in children with autism and other endogenous disorders. Thus, the today’s agenda focuses on a thorough investigation of abnormalities which may serve as somatic predictors of psychic disorders This aspect is of particular importance for pediatricians who will be the first doctors dealing with such patients and may raise the issue of providing medical care rehabilitation care to them KEYWORDS: children, connective tissue dysplasia, mitral valve prolapse, diathesis, schizophrenia spectrum disorders. FOR CITATION: Kotlyarov V.L., Kalinina M.A., Kozlovskaya G.V., Shimonova G.N. Congenital connective tissue dysplasia and minor heart defects in children as a risk factor of psychic disorders. Russian Journal of Woman and Child Health. 2022;5(4):346–350 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-346-350.
{"title":"Врожденная дисплазия соединительной ткани и малые аномалии развития сердца у детей как фактор риска развития психической патологии","authors":"V. Kotlyarov, M.A. Kalinina, G.V. Kozlovskaya, G.N. Shimonova","doi":"10.32364/2618-8430-2022-5-4-346-350","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-346-350","url":null,"abstract":"The article presents a short literature review highlighting a potential genesis of the disease and genetic background of congenital connective tissue dysplasia, as well as its association with certain congenital biochemical and mediator abnormalities. Over the past years, there has been a substantial growth of publications discussing a close relationship between connective tissue diseases and psychic deviations in children with autism and other endogenous disorders. Thus, the today’s agenda focuses on a thorough investigation of abnormalities which may serve as somatic predictors of psychic disorders This aspect is of particular importance for pediatricians who will be the first doctors dealing with such patients and may raise the issue of providing medical care rehabilitation care to them KEYWORDS: children, connective tissue dysplasia, mitral valve prolapse, diathesis, schizophrenia spectrum disorders. FOR CITATION: Kotlyarov V.L., Kalinina M.A., Kozlovskaya G.V., Shimonova G.N. Congenital connective tissue dysplasia and minor heart defects in children as a risk factor of psychic disorders. Russian Journal of Woman and Child Health. 2022;5(4):346–350 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-346-350.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69551071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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