Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-51-57
A. A. Pashchenko, L. Dzhokhadze, Y. Dobrokhotova, T. Kotomina, A. N. Efremov
Interpretation of smears identified group B Streptococcus (S. agalactiae) in various titers in urogenital epithelium depending on gestation term and management of pregnant women requiring antibiotics are still disputable among inpatient and outpatient obstetricians and gynecologists. It was demonstrated that S. agalactiae persistence in pregnant women without timely antibacterial therapy during delivery to eliminate microbes is reliably associated with severe infectious complications in the early neonatal period (e.g., newborn meningitis or sepsis). This paper systematically reviews recent publications and analyzes current clinical guidelines of global professional medical associations on the colonization of the urogenital tract of pregnant women with group B Streptococcus. The authors provide recommendations on managing pregnant women with S. agalactiae infection depending on gestation terms and microbial count to improve the diagnosis and medical treatment algorithms. Principles of rational pharmacotherapy in these pregnant women (including those in the intranatal period) are addressed. KEYWORDS: group B streptococcus, S. agalactia, GBS colonization, systematic review, asymptomatic bacteriuria, rational pharmacotherapy, pregnant women. FOR CITATION: Pashchenko A.A., Dzhokhadze L.S., Dobrokhotova Yu.E. et al. Practical tips on counseling pregnant women with group B Streptococcus infection. Russian Journal of Woman and Child Health. 2022;5(1):51–57 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-51-57.
{"title":"Practical tips on counseling pregnant women with group B Streptococcus infection","authors":"A. A. Pashchenko, L. Dzhokhadze, Y. Dobrokhotova, T. Kotomina, A. N. Efremov","doi":"10.32364/2618-8430-2022-5-1-51-57","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-51-57","url":null,"abstract":"Interpretation of smears identified group B Streptococcus (S. agalactiae) in various titers in urogenital epithelium depending on gestation term and management of pregnant women requiring antibiotics are still disputable among inpatient and outpatient obstetricians and gynecologists. It was demonstrated that S. agalactiae persistence in pregnant women without timely antibacterial therapy during delivery to eliminate microbes is reliably associated with severe infectious complications in the early neonatal period (e.g., newborn meningitis or sepsis). This paper systematically reviews recent publications and analyzes current clinical guidelines of global professional medical associations on the colonization of the urogenital tract of pregnant women with group B Streptococcus. The authors provide recommendations on managing pregnant women with S. agalactiae infection depending on gestation terms and microbial count to improve the diagnosis and medical treatment algorithms. Principles of rational pharmacotherapy in these pregnant women (including those in the intranatal period) are addressed. KEYWORDS: group B streptococcus, S. agalactia, GBS colonization, systematic review, asymptomatic bacteriuria, rational pharmacotherapy, pregnant women. FOR CITATION: Pashchenko A.A., Dzhokhadze L.S., Dobrokhotova Yu.E. et al. Practical tips on counseling pregnant women with group B Streptococcus infection. Russian Journal of Woman and Child Health. 2022;5(1):51–57 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-51-57.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69548839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-85-89
L. I. Mozzhukhina, S.E. Kalgina, L. E. Stroeva, V.A. Teyf
The causes of late hemorrhagic disease of the newborn (HDN) are parenteral nutrition, severe diseases (e.g., biliary atresia, congenital or inherited diseases associated with cholestasis, short bowel syndrome), exclusive breastfeeding, and digestive disorders with malabsorption. Meanwhile, vitamin K deficiency develops in severe malabsorption and digestive disorders resulting from an irrational diet of a nursing mother or viral infections with the intestinal syndrome. Lipidogram of feces was evaluated by thin-layer chromatography in 15 children with late HDN. Lipidogram demonstrated high lipid content (on average, 77.47 μg/g). Moreover, the maximum levels of higher fatty acids, cholesterol, and phospholipids were detected in children with the most severe clinical presentations of bleeding. Clinical manifestations of hemorrhagic syndrome included umbilical cord bleeding (66.7%), gastrointestinal bleeding (28.5%), and intracranial hemorrhage (6.7%). In addition, all children have one or more clinical symptoms of digestive disorders (i.e., frequent bowel movements, excessive pooping, watery diarrhea). Occasionally, bloody streaks were reported. Education of nursing mothers to plan their diet and follow a balanced diet demonstrates that strict adherence to these recommendations significantly reduces the risks of vitamin K deficiency in newborns and late HDN. KEYWORDS: vitamin K, vitamin K deficiency bleeding, breastfeeding, children, lipidogram of feces, late hemorrhagic disease of the newborn, malabsorption. FOR CITATION: Mozzhukhina L.I., Kalgina S.E., Stroeva L.E., Teyf V.A. Role of fat malabsorption during breastfeeding in late hemorrhagic disease of the newborn. Russian Journal of Woman and Child Health. 2022;5(1):85–89 (in Russ.). DOI: 10.32364/2618- 8430-2022-5-1-85-89
{"title":"Role of fat malabsorption during breastfeeding in late hemorrhagic disease of the newborn","authors":"L. I. Mozzhukhina, S.E. Kalgina, L. E. Stroeva, V.A. Teyf","doi":"10.32364/2618-8430-2022-5-1-85-89","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-85-89","url":null,"abstract":"The causes of late hemorrhagic disease of the newborn (HDN) are parenteral nutrition, severe diseases (e.g., biliary atresia, congenital or inherited diseases associated with cholestasis, short bowel syndrome), exclusive breastfeeding, and digestive disorders with malabsorption. Meanwhile, vitamin K deficiency develops in severe malabsorption and digestive disorders resulting from an irrational diet of a nursing mother or viral infections with the intestinal syndrome. Lipidogram of feces was evaluated by thin-layer chromatography in 15 children with late HDN. Lipidogram demonstrated high lipid content (on average, 77.47 μg/g). Moreover, the maximum levels of higher fatty acids, cholesterol, and phospholipids were detected in children with the most severe clinical presentations of bleeding. Clinical manifestations of hemorrhagic syndrome included umbilical cord bleeding (66.7%), gastrointestinal bleeding (28.5%), and intracranial hemorrhage (6.7%). In addition, all children have one or more clinical symptoms of digestive disorders (i.e., frequent bowel movements, excessive pooping, watery diarrhea). Occasionally, bloody streaks were reported. Education of nursing mothers to plan their diet and follow a balanced diet demonstrates that strict adherence to these recommendations significantly reduces the risks of vitamin K deficiency in newborns and late HDN. KEYWORDS: vitamin K, vitamin K deficiency bleeding, breastfeeding, children, lipidogram of feces, late hemorrhagic disease of the newborn, malabsorption. FOR CITATION: Mozzhukhina L.I., Kalgina S.E., Stroeva L.E., Teyf V.A. Role of fat malabsorption during breastfeeding in late hemorrhagic disease of the newborn. Russian Journal of Woman and Child Health. 2022;5(1):85–89 (in Russ.). DOI: 10.32364/2618- 8430-2022-5-1-85-89","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"190 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-100-105
E. Kudinova, K.I. Mozharina
Aim: to analyze subjective and objective parameters of eye functioning and evaluate the role of hemostasis abnormalities for shaping groups of high risk for preeclampsia. Patients and Methods: 58 women were examined (history taking, eye and obstetric-gynecological exams, lab tests) to assess their ocular, somatic, and reproductive status and pregnancy course in the third trimester. Twenty-five women were diagnosed with preeclampsia: 13 women without ametropia at baseline were included in group 2, and 12 women with myopia prior to pregnancy were included in group 3. Controls were pregnant women without preeclampsia, i.e., 18 women with healthy pregnancy but no myopia, and 15 pregnant women without preeclampsia but with myopia. In addition, fibrinogen, activated partial thromboplastin time (APTT), soluble fibrin monomer complex (SFMC), and platelets were measured. Results: subjective and objective symptoms of visual disorders in pregnant women associated with hemostatic abnormalities were identified. These signs are considered preeclampsia predictors. The history of reproductive loss, headaches, and visual disorders during pregnancy are typical for preeclampsia women. Most susceptible individuals are women with preeclampsia and myopia who present with complaints of floaters, scotomas, photopsia, and diplopia. These signs illustrate vascular ischemia. Other relevant parameters are reduced platelet count (p<0.01) and APTT (p<0.01), and increased fibrinogen (p<0.01) and SFMC (p<0.002). Conclusion: careful diagnosis of cerebral neurological signs and visual disorders allows for timely diagnostic search and valid peripheral blood and hemostasis testing to improve management of these women and shape risk groups of preeclampsia without lethal complications. KEYWORDS: eye, eye fundus, myopia, photopsia, scotoma, diplopia, reproductive loss, preeclampsia, hemostasis. FOR CITATION: Kudinova E.G., Mozharina K.I. Early prognosis of preeclampsia risk based on visual disorders and hemostatic abnormalities. Russian Journal of Woman and Child Health. 2022;5(2):100–105 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-100-105
{"title":"Early prognosis of preeclampsia risk based on visual disorders and hemostatic abnormalities","authors":"E. Kudinova, K.I. Mozharina","doi":"10.32364/2618-8430-2022-5-2-100-105","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-100-105","url":null,"abstract":"Aim: to analyze subjective and objective parameters of eye functioning and evaluate the role of hemostasis abnormalities for shaping groups of high risk for preeclampsia. Patients and Methods: 58 women were examined (history taking, eye and obstetric-gynecological exams, lab tests) to assess their ocular, somatic, and reproductive status and pregnancy course in the third trimester. Twenty-five women were diagnosed with preeclampsia: 13 women without ametropia at baseline were included in group 2, and 12 women with myopia prior to pregnancy were included in group 3. Controls were pregnant women without preeclampsia, i.e., 18 women with healthy pregnancy but no myopia, and 15 pregnant women without preeclampsia but with myopia. In addition, fibrinogen, activated partial thromboplastin time (APTT), soluble fibrin monomer complex (SFMC), and platelets were measured. Results: subjective and objective symptoms of visual disorders in pregnant women associated with hemostatic abnormalities were identified. These signs are considered preeclampsia predictors. The history of reproductive loss, headaches, and visual disorders during pregnancy are typical for preeclampsia women. Most susceptible individuals are women with preeclampsia and myopia who present with complaints of floaters, scotomas, photopsia, and diplopia. These signs illustrate vascular ischemia. Other relevant parameters are reduced platelet count (p<0.01) and APTT (p<0.01), and increased fibrinogen (p<0.01) and SFMC (p<0.002). Conclusion: careful diagnosis of cerebral neurological signs and visual disorders allows for timely diagnostic search and valid peripheral blood and hemostasis testing to improve management of these women and shape risk groups of preeclampsia without lethal complications. KEYWORDS: eye, eye fundus, myopia, photopsia, scotoma, diplopia, reproductive loss, preeclampsia, hemostasis. FOR CITATION: Kudinova E.G., Mozharina K.I. Early prognosis of preeclampsia risk based on visual disorders and hemostatic abnormalities. Russian Journal of Woman and Child Health. 2022;5(2):100–105 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-100-105","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-1-78-84
A. I. Safronova, E. A. Pyr’eva, O. Georgieva
Dietary patterns established at a young age have a significant impact on eating disorders. Therefore, the impact of individual food products is crucial. This paper discusses the use of drinks in early childhood nutrition, given novel ideas on the effects of specific nutrients on a child’s health. The most disputable issue is the intake of simple carbs found in drinks. Currently, no guidelines on controlling added sugars in children under two years are available. The paper addresses the drink types containing carbohydrates included in childhood nutrition and the nutritional value of juices of various substrates. Foreign and Russian recommendations on quantitative limitations of high-carbohydrate beverages in childhood nutrition (given the effect of their overconsumption on the development of metabolic disorders) are highlighted. The authors describe specialized juice-containing beverages for childhood nutrition, requirements for manufacturing, and enrichment with nutrients. The assessment results on the nutrient content of juices for child nutrition are discussed. Finally, current trends in the manufacturing of juice-containing drinks and their role in providing young children with nutrients are uncovered. KEYWORDS: children, juices, drinks, nutrients, simple carbs. FOR CITATION: Safronova A.I., Pyr’eva E.A, Georgieva O.V. Beverages in child nutrition. Russian Journal of Woman and Child Health. 2022;5(1):78–84 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-78-84.
{"title":"Beverages in child nutrition","authors":"A. I. Safronova, E. A. Pyr’eva, O. Georgieva","doi":"10.32364/2618-8430-2022-5-1-78-84","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-1-78-84","url":null,"abstract":"Dietary patterns established at a young age have a significant impact on eating disorders. Therefore, the impact of individual food products is crucial. This paper discusses the use of drinks in early childhood nutrition, given novel ideas on the effects of specific nutrients on a child’s health. The most disputable issue is the intake of simple carbs found in drinks. Currently, no guidelines on controlling added sugars in children under two years are available. The paper addresses the drink types containing carbohydrates included in childhood nutrition and the nutritional value of juices of various substrates. Foreign and Russian recommendations on quantitative limitations of high-carbohydrate beverages in childhood nutrition (given the effect of their overconsumption on the development of metabolic disorders) are highlighted. The authors describe specialized juice-containing beverages for childhood nutrition, requirements for manufacturing, and enrichment with nutrients. The assessment results on the nutrient content of juices for child nutrition are discussed. Finally, current trends in the manufacturing of juice-containing drinks and their role in providing young children with nutrients are uncovered. KEYWORDS: children, juices, drinks, nutrients, simple carbs. FOR CITATION: Safronova A.I., Pyr’eva E.A, Georgieva O.V. Beverages in child nutrition. Russian Journal of Woman and Child Health. 2022;5(1):78–84 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-78-84.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-138-145
A. Savicheva, P. A. Shadrova
nflammatory diseases and dysbiosis provoked by opportunistic microbes currently rank first among lower reproductive tract infections in women. Lactobacilli are predominant in the vaginal microecosystem that is considered the first line of defense against infectious agents. Changes in hormonal profile, the pattern of intimate hygiene and sex life, and other factors impair the vaginal microecosystem. Diseases resulting from the activation of aerobic and anaerobic opportunistic microbes are particularly harmful during pregnancy, since they cause serious reproductive disorders and significantly increase the risks of perinatal complications. Frequent recurrences due to growing antibiotic resistance and the lack of potential antimicrobial treatment in the first trimester of pregnancy force to search for alternative therapeutic tools with good efficacy and safety. Topical agents containing lactic acid decrease vaginal pH and provide unfavorable conditions for the activity of opportunistic microbes, thereby maintaining the protective functions of Lactobacilli. Lactic acid is a natural chemical for this locus. As a result, agents containing this compound are virtually lacking side effects. They can be used along with antibiotics or as monotherapy. KEYWORDS: bacterial vaginosis, aerobic vaginitis, lactic acid, opportunistic microbes, vaginal microbiota, Lactobacilli, dysbiosis, pregnancy, normal flora. FOR CITATION: Savicheva A.M., Shadrova P.A. Potential use of lactic acid in obstetrics and gynecology. Russian Journal of Woman and Child Health. 2022;5(2):138–145 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-138-145.
{"title":"Potential use of lactic acid in obstetrics and gynecology","authors":"A. Savicheva, P. A. Shadrova","doi":"10.32364/2618-8430-2022-5-2-138-145","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-138-145","url":null,"abstract":"nflammatory diseases and dysbiosis provoked by opportunistic microbes currently rank first among lower reproductive tract infections in women. Lactobacilli are predominant in the vaginal microecosystem that is considered the first line of defense against infectious agents. Changes in hormonal profile, the pattern of intimate hygiene and sex life, and other factors impair the vaginal microecosystem. Diseases resulting from the activation of aerobic and anaerobic opportunistic microbes are particularly harmful during pregnancy, since they cause serious reproductive disorders and significantly increase the risks of perinatal complications. Frequent recurrences due to growing antibiotic resistance and the lack of potential antimicrobial treatment in the first trimester of pregnancy force to search for alternative therapeutic tools with good efficacy and safety. Topical agents containing lactic acid decrease vaginal pH and provide unfavorable conditions for the activity of opportunistic microbes, thereby maintaining the protective functions of Lactobacilli. Lactic acid is a natural chemical for this locus. As a result, agents containing this compound are virtually lacking side effects. They can be used along with antibiotics or as monotherapy. KEYWORDS: bacterial vaginosis, aerobic vaginitis, lactic acid, opportunistic microbes, vaginal microbiota, Lactobacilli, dysbiosis, pregnancy, normal flora. FOR CITATION: Savicheva A.M., Shadrova P.A. Potential use of lactic acid in obstetrics and gynecology. Russian Journal of Woman and Child Health. 2022;5(2):138–145 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-138-145.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-4-340-345
G. R. Sagitova, V. A. Shuldais, N. V. Klyueva, E. M. Shaforostova, I.B. Konotopova
Background: currently, the term "post-COVID conditions" has been commonly used in healthcare practices. It includes impairments of multiple human organ systems. Many international and Russian researchers have mentioned in their studies that such patients, including children, are at a higher risk of developing psychoneurological disorders. Aim: to assess the clinical efficacy of a syrup, containing choline, glycine, lysine, B vitamins, zinc, magnesium, lemon balm and mint extracts to cope with the manifestations of anxiety disorders developed in children after COVID-19 infection. Patients and Methods: this prospective study involved 65 children, 7–11 years old, who had mild cases of COVID-19 and developed manifestations of anxiety disorders. All patients were given recommendations including nutritional therapy, sleep and rest routine, walking into the fresh air, and limiting the time children spend on their phones, computers and TV. 40 patients, 20 of whom were girls, of the treatment group (TG) additionally received a biologically active supplement (BAS), "Kidz Syrup with lemon balm and mint", at the dosage of 1 stick (5 ml) 3 times a day for 42 days. 25 children, 16 of whom were girls, were included in the control group (CG), receiving only routine treatment. The duration of follow-up period was 42 days. A questionnaire was filled out by children’s parents to assess the severity of asthenic syndrome. Results: after one month of treatment with the BAS added to the routine therapy, the TG patients demonstrated trends in lower severity of all symptoms of asthenic syndrome vs that at the baseline (р<0.05, unpaired t-test). Such trends were not reported in the control group (р>0.05, unpaired t-test). Parents of the TG children reported more physical activity and interest, better sleep and appetite, normalizing kids’ behavior and improving relationships. In the CG patients, receiving routine therapy, these changes were less pronounced. Seven of 40 patients did not like taking the syrup because of the unpleasant syrup taste. It was the reason why three of 40 patients declined further participation in the study. None of the children reported allergic reactions. Conclusion: a biologically active substance "Kidz syrup with lemon balm and mint" given to the primary school-aged children who survived COVID-19 and developed manifestations of anxiety disorders, helps to improve their ability to manage emotional distress, concentrate attention and memory, and has the protective effect against the increasing mental burdens. KEYWORDS: children, COVID-19, post-COVID conditions, anxiety disorders, biologically active supplement, lemon balm and mint. FOR CITATION: Sagitova G.R., Shuldais V.A., Klyueva N.V. et al. Management of anxiety disorders in children who survived the novel coronavirus infection. Russian Journal of Woman and Child Health. 2022;5(4):340–345 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-340-345.
{"title":"Management of anxiety disorders in children who survived the novel coronavirus infection","authors":"G. R. Sagitova, V. A. Shuldais, N. V. Klyueva, E. M. Shaforostova, I.B. Konotopova","doi":"10.32364/2618-8430-2022-5-4-340-345","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-4-340-345","url":null,"abstract":"Background: currently, the term \"post-COVID conditions\" has been commonly used in healthcare practices. It includes impairments of multiple human organ systems. Many international and Russian researchers have mentioned in their studies that such patients, including children, are at a higher risk of developing psychoneurological disorders. Aim: to assess the clinical efficacy of a syrup, containing choline, glycine, lysine, B vitamins, zinc, magnesium, lemon balm and mint extracts to cope with the manifestations of anxiety disorders developed in children after COVID-19 infection. Patients and Methods: this prospective study involved 65 children, 7–11 years old, who had mild cases of COVID-19 and developed manifestations of anxiety disorders. All patients were given recommendations including nutritional therapy, sleep and rest routine, walking into the fresh air, and limiting the time children spend on their phones, computers and TV. 40 patients, 20 of whom were girls, of the treatment group (TG) additionally received a biologically active supplement (BAS), \"Kidz Syrup with lemon balm and mint\", at the dosage of 1 stick (5 ml) 3 times a day for 42 days. 25 children, 16 of whom were girls, were included in the control group (CG), receiving only routine treatment. The duration of follow-up period was 42 days. A questionnaire was filled out by children’s parents to assess the severity of asthenic syndrome. Results: after one month of treatment with the BAS added to the routine therapy, the TG patients demonstrated trends in lower severity of all symptoms of asthenic syndrome vs that at the baseline (р<0.05, unpaired t-test). Such trends were not reported in the control group (р>0.05, unpaired t-test). Parents of the TG children reported more physical activity and interest, better sleep and appetite, normalizing kids’ behavior and improving relationships. In the CG patients, receiving routine therapy, these changes were less pronounced. Seven of 40 patients did not like taking the syrup because of the unpleasant syrup taste. It was the reason why three of 40 patients declined further participation in the study. None of the children reported allergic reactions. Conclusion: a biologically active substance \"Kidz syrup with lemon balm and mint\" given to the primary school-aged children who survived COVID-19 and developed manifestations of anxiety disorders, helps to improve their ability to manage emotional distress, concentrate attention and memory, and has the protective effect against the increasing mental burdens. KEYWORDS: children, COVID-19, post-COVID conditions, anxiety disorders, biologically active supplement, lemon balm and mint. FOR CITATION: Sagitova G.R., Shuldais V.A., Klyueva N.V. et al. Management of anxiety disorders in children who survived the novel coronavirus infection. Russian Journal of Woman and Child Health. 2022;5(4):340–345 (in Russ.). DOI: 10.32364/2618-8430-2022-5-4-340-345.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69551121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-122-128
A. A. Paschenko, Y. Dobrokhotova, D. Fomina, M.G. Pashchenko
The article presents the analysis of literature data on the pathogenesis, course and pharmacotherapy in pregnancy during respiratory allergic diseases. The article also considers the systematized ARIA recommendations (Updated 2020) on the diagnosis and pharmacotherapy of allergic rhinitis (AR) in pregnancy, differential diagnosis concerning nasal breathing disorders of atopic and non-atopic etiology during gestation, and the developed therapeutic methods for the patient management (in particular, pregnant women) with an allergic phenotype (a combination of asthma with allergic rhinitis and/or atopic dermatitis). The association between the uncontrolled course of allergic rhinitis in pregnant women and the risk of the bronchial asthma onset has been proven. Of utmost importance, for improving perinatal outcomes is the optimization of therapy and symptom control of allergic diseases during pregnancy in the interdisciplinary practice of an obstetrician-gynecologist and allergist/immunologist. AR in pregnancy should be differentiated from the most common form of nasal breathing disorders in pregnant women — vasomotor rhinitis. Severe uncontrolled vasomotor rhinitis in pregnant women, as an individual nosological form, can worsen the existing AR and bronchial asthma course. The authors present a mathod for the AR step therapy based on pharmacological characteristics and safety profile of drugs in pregnancy. KEYWORDS: allergic rhinitis, bronchial asthma, pregnancy, vasomotor rhinitis of pregnant women, pharmacotherapy, obstetric complications. FOR CITATION: Paschenko A.A., Dobrokhotova Yu.E., Fomina D.S., Pashchenko M.G. Uncontrolled course of respiratory allergic diseases in pregnant women. Russian Journal of Woman and Child Health. 2022;5(2):122–128 (in Russ.). DOI: 10.32364/2618-8430- 2022-5-2-122-128.
{"title":"Uncontrolled course of respiratory allergic diseases in pregnant women","authors":"A. A. Paschenko, Y. Dobrokhotova, D. Fomina, M.G. Pashchenko","doi":"10.32364/2618-8430-2022-5-2-122-128","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-122-128","url":null,"abstract":"The article presents the analysis of literature data on the pathogenesis, course and pharmacotherapy in pregnancy during respiratory allergic diseases. The article also considers the systematized ARIA recommendations (Updated 2020) on the diagnosis and pharmacotherapy of allergic rhinitis (AR) in pregnancy, differential diagnosis concerning nasal breathing disorders of atopic and non-atopic etiology during gestation, and the developed therapeutic methods for the patient management (in particular, pregnant women) with an allergic phenotype (a combination of asthma with allergic rhinitis and/or atopic dermatitis). The association between the uncontrolled course of allergic rhinitis in pregnant women and the risk of the bronchial asthma onset has been proven. Of utmost importance, for improving perinatal outcomes is the optimization of therapy and symptom control of allergic diseases during pregnancy in the interdisciplinary practice of an obstetrician-gynecologist and allergist/immunologist. AR in pregnancy should be differentiated from the most common form of nasal breathing disorders in pregnant women — vasomotor rhinitis. Severe uncontrolled vasomotor rhinitis in pregnant women, as an individual nosological form, can worsen the existing AR and bronchial asthma course. The authors present a mathod for the AR step therapy based on pharmacological characteristics and safety profile of drugs in pregnancy. KEYWORDS: allergic rhinitis, bronchial asthma, pregnancy, vasomotor rhinitis of pregnant women, pharmacotherapy, obstetric complications. FOR CITATION: Paschenko A.A., Dobrokhotova Yu.E., Fomina D.S., Pashchenko M.G. Uncontrolled course of respiratory allergic diseases in pregnant women. Russian Journal of Woman and Child Health. 2022;5(2):122–128 (in Russ.). DOI: 10.32364/2618-8430- 2022-5-2-122-128.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-3-188-193
I. Il'ina, Y. Dobrokhotova
Aim: to improve outcomes of the surgical management of cervix disorders by using a hemostatic agent with antimicrobial activity. Patients and Methods: the study included 47 women, 25–45 years of age, with CIN II/III to whom cervical radiofrequency ablation was performed. The main group comprised 26 (55.3%) patients. During the ablation procedure, a 1% aqueous solution of incomplete polyacrylic acid silver salt with integrated nanoparticles was used as an additional treatment for this group of patients. The control group consisted of 21 (44.7%) patients for whom the standard ablation technique was used. The assessed criteria included the clinical course and laboratory test results before and three months after the surgical treatment, as well as the bleeding rates. Results: in the main group of patients, the mean leucocyte number in the smear after the treatment was 9.2±1.2 per field of vision, in the control group — 18.5±2.9; pH of the vaginal discharge — 4.2±0.2 (from 3.8 to 4.5) and 4.7±0.2 (from 4.2 to 5.8), respectively. Intraoperative bleeding from the surgical wound which required additional manipulations was reported in 2 (7.7%) patients of the main group and 2 (9.5%) patients of the control group. Ten days after the surgery, one patient (3.8%) from the main group had complaints on heavy bloody vaginal discharge. Three (14,3%) patients from the control group had the same complaint 11–13 days after the surgery (3.7 relative risk, 95% confidence interval (CI) 1,0–18,2) which required the use of tranexamic acid as tablets for oral administration. Three months after the surgery the clue cells were found in one (3.8%) patient of the main group and in 7 (33.3%) patients of the control group (8.7 relative risk, 95% CI 1.2–16.5), and the fungal mycelia — only in 8 (38.1%) patients of the control group. Conclusion: the use of a 1% aqueous solution of incomplete polyacrylic acid silver salt with integrated nanoparticles during the cervical ablation resulted in a statistically significant reduction of the bleeding risk and improved the vaginal microflora profile in postoperative period. KEYWORDS: cervical dysplasia, cervical excision, cervical conization, bacterial vaginosis, hemostatic agent, bleeding. FOR CITATION: Il’ina I.Yu., Dobrokhotova Yu.E. Optimizing surgical management of uterine cervix disorders. Russian Journal of Woman and Child Health. 2022;5(3):188–193 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-188-193.
{"title":"Optimizing surgical management of uterine cervix disorders","authors":"I. Il'ina, Y. Dobrokhotova","doi":"10.32364/2618-8430-2022-5-3-188-193","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-3-188-193","url":null,"abstract":"Aim: to improve outcomes of the surgical management of cervix disorders by using a hemostatic agent with antimicrobial activity. Patients and Methods: the study included 47 women, 25–45 years of age, with CIN II/III to whom cervical radiofrequency ablation was performed. The main group comprised 26 (55.3%) patients. During the ablation procedure, a 1% aqueous solution of incomplete polyacrylic acid silver salt with integrated nanoparticles was used as an additional treatment for this group of patients. The control group consisted of 21 (44.7%) patients for whom the standard ablation technique was used. The assessed criteria included the clinical course and laboratory test results before and three months after the surgical treatment, as well as the bleeding rates. Results: in the main group of patients, the mean leucocyte number in the smear after the treatment was 9.2±1.2 per field of vision, in the control group — 18.5±2.9; pH of the vaginal discharge — 4.2±0.2 (from 3.8 to 4.5) and 4.7±0.2 (from 4.2 to 5.8), respectively. Intraoperative bleeding from the surgical wound which required additional manipulations was reported in 2 (7.7%) patients of the main group and 2 (9.5%) patients of the control group. Ten days after the surgery, one patient (3.8%) from the main group had complaints on heavy bloody vaginal discharge. Three (14,3%) patients from the control group had the same complaint 11–13 days after the surgery (3.7 relative risk, 95% confidence interval (CI) 1,0–18,2) which required the use of tranexamic acid as tablets for oral administration. Three months after the surgery the clue cells were found in one (3.8%) patient of the main group and in 7 (33.3%) patients of the control group (8.7 relative risk, 95% CI 1.2–16.5), and the fungal mycelia — only in 8 (38.1%) patients of the control group. Conclusion: the use of a 1% aqueous solution of incomplete polyacrylic acid silver salt with integrated nanoparticles during the cervical ablation resulted in a statistically significant reduction of the bleeding risk and improved the vaginal microflora profile in postoperative period. KEYWORDS: cervical dysplasia, cervical excision, cervical conization, bacterial vaginosis, hemostatic agent, bleeding. FOR CITATION: Il’ina I.Yu., Dobrokhotova Yu.E. Optimizing surgical management of uterine cervix disorders. Russian Journal of Woman and Child Health. 2022;5(3):188–193 (in Russ.). DOI: 10.32364/2618-8430-2022-5-3-188-193.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-129-137
Ar.A. Mikhelson, E. Lebedenko, O. Gayda, Al.A. Mikhelson, T. Feoktistova, A. Mikhelson
Deficiency or excess of microelements and vitamins significantly affects the vital activity at each step of human life. This is particularly significant during pregnancy because of immediate and long-term effects on the fetus and newborn. Iron is one of the essential microelements and plays an important role in the mechanisms of biological oxidation. Iron metabolism in the human body is quite complex and impossible without synergy with other metals and vitamins. Iron is most closely related to folic acid and is critical for many vital processes, including embryogenesis. Considering that iron and folic acid deficiencies (leading to anemias in extreme cases) negatively affect pregnancy course, its favorable outcome, and prognosis for a newborn, these conditions are to be addressed. Medications are diverse, they should be selected based on the specificity of iron and folic acid metabolism. Among preparations currently available in Russia, combined ones best meet the requirements (iron valence, iron compounds, association with synergid components, dosage form). KEYWORDS: iron, folic acid, iron-deficiency anemia, folate-deficiency anemia, therapy, combined preparations. FOR CITATION: Mikhelson Ar.A., Lebedenko E.Yu., Gayda O.V. et al. Iron deficiencies in obstetric-gynecologic practice. Russian Journal of Woman and Child Health. 2022;5(2):129–137 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-129-137.
{"title":"Iron deficiencies in obstetric-gynecologic practice","authors":"Ar.A. Mikhelson, E. Lebedenko, O. Gayda, Al.A. Mikhelson, T. Feoktistova, A. Mikhelson","doi":"10.32364/2618-8430-2022-5-2-129-137","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-129-137","url":null,"abstract":"Deficiency or excess of microelements and vitamins significantly affects the vital activity at each step of human life. This is particularly significant during pregnancy because of immediate and long-term effects on the fetus and newborn. Iron is one of the essential microelements and plays an important role in the mechanisms of biological oxidation. Iron metabolism in the human body is quite complex and impossible without synergy with other metals and vitamins. Iron is most closely related to folic acid and is critical for many vital processes, including embryogenesis. Considering that iron and folic acid deficiencies (leading to anemias in extreme cases) negatively affect pregnancy course, its favorable outcome, and prognosis for a newborn, these conditions are to be addressed. Medications are diverse, they should be selected based on the specificity of iron and folic acid metabolism. Among preparations currently available in Russia, combined ones best meet the requirements (iron valence, iron compounds, association with synergid components, dosage form). KEYWORDS: iron, folic acid, iron-deficiency anemia, folate-deficiency anemia, therapy, combined preparations. FOR CITATION: Mikhelson Ar.A., Lebedenko E.Yu., Gayda O.V. et al. Iron deficiencies in obstetric-gynecologic practice. Russian Journal of Woman and Child Health. 2022;5(2):129–137 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-129-137.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.32364/2618-8430-2022-5-2-146-152
Y. Chebotareva, Y. Petrov
Dysmenorrhea is a complex of symptoms that most commonly occurs a day before or on the first day of menstruation. This paper describes in detail risk factors and prevalence of the primary and secondary dysmenorrhea. The authors discuss the etiology and pathogenesis of period pain, the mechanism of analgesic action of combined analgesic, and its use for primary dysmenorrhea depending on its severity. Systematic reviews of the comparative analysis of the efficacy of management strategies for primary dysmenorrhea have demonstrated that NSAIDs are beneficial for moderate-to-severe pelvic pain. A broad effect of NSAIDs on pain relief is mediated by reducing the production of prostaglandins (inflammatory mediators). NSAIDs or antispasmodics are most commonly used to reduce dysmenorrhea symptoms. Russian scientists focus on fixed-dose combinations of NSAIDs and myotropic antispasmodics, e.g., ibuprofen, pitofenone hydrochloride (myotropic antispasmodic), and fenpiverinium bromide (M-cholinoblocker with central and peripheral action). The pathogenic basis for the use of this combination for primary dysmenorrhea is addressed. KEYWORDS: primary dysmenorrhea, pelvic pain, NSAIDs, menstrual pain, myotropic antispasmodic, M-cholinoblocker, fixed-dose combination. FOR CITATION: Chebotareva Yu.Yu., Petrov Yu.A. Pathogenic basis for the use of a combined analgesic for pain relief in primary dysmenorrhea. Russian Journal of Woman and Child Health. 2022;5(2):146–152 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-146-152.
{"title":"Pathogenic basis for the use of a combined analgesic for pain relief in primary dysmenorrhea","authors":"Y. Chebotareva, Y. Petrov","doi":"10.32364/2618-8430-2022-5-2-146-152","DOIUrl":"https://doi.org/10.32364/2618-8430-2022-5-2-146-152","url":null,"abstract":"Dysmenorrhea is a complex of symptoms that most commonly occurs a day before or on the first day of menstruation. This paper describes in detail risk factors and prevalence of the primary and secondary dysmenorrhea. The authors discuss the etiology and pathogenesis of period pain, the mechanism of analgesic action of combined analgesic, and its use for primary dysmenorrhea depending on its severity. Systematic reviews of the comparative analysis of the efficacy of management strategies for primary dysmenorrhea have demonstrated that NSAIDs are beneficial for moderate-to-severe pelvic pain. A broad effect of NSAIDs on pain relief is mediated by reducing the production of prostaglandins (inflammatory mediators). NSAIDs or antispasmodics are most commonly used to reduce dysmenorrhea symptoms. Russian scientists focus on fixed-dose combinations of NSAIDs and myotropic antispasmodics, e.g., ibuprofen, pitofenone hydrochloride (myotropic antispasmodic), and fenpiverinium bromide (M-cholinoblocker with central and peripheral action). The pathogenic basis for the use of this combination for primary dysmenorrhea is addressed. KEYWORDS: primary dysmenorrhea, pelvic pain, NSAIDs, menstrual pain, myotropic antispasmodic, M-cholinoblocker, fixed-dose combination. FOR CITATION: Chebotareva Yu.Yu., Petrov Yu.A. Pathogenic basis for the use of a combined analgesic for pain relief in primary dysmenorrhea. Russian Journal of Woman and Child Health. 2022;5(2):146–152 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-146-152.","PeriodicalId":34075,"journal":{"name":"RMZh Mat'' i ditia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69549883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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