Pub Date : 2023-08-21DOI: 10.1097/jd9.0000000000000340
Xiaoyan Huang, Yi Xiao, D. Jing, M. Shen, Li-Xia Lu
Chronic arsenic exposure causes skin lesions including skin cancers, pigmentary changes, and keratosis. Genetic polymorphism in arsenic metabolism may increase susceptibility to the development of arsenic-related skin lesions. This study was performed to determine whether arsenic metabolism-related gene variants are associated with arsenic-related pigmentary changes. This case–control study involved 189 patients with arsenic-related pigmentary changes and 103 controls. Thirty-eight polymorphisms in 10 genes determined by mass spectrometry assay served as candidate drivers of arsenic-induced pigmentary changes. Urine and plasma arsenic levels were determined by inductively coupled plasma mass spectrometry. Hair arsenic concentrations were measured by nondispersive atomic fluorescence spectrometry. Arsenic metabolites in urine were determined using high-pressure liquid chromatography hyphenated with hydride generation and inductively coupled plasma mass spectrometry. Serum folate was measured using a folate radioassay kit. Analysis of variance, nonparametric test, or the chi-square test was selected according to the data distribution. Spearman correlation analysis was used to determine the correlation between two parameters. Logistic regression was used to estimate the effect size of SNPs. The arsenic concentrations in urine, plasma, and hair and the urine arsenic species were not significantly different between cases and controls. Logistic regression revealed that among the polymorphisms, the methionine synthase (MTR) rs1805087 polymorphism showed a protective effect against arsenic-related pigmentary changes. In the codominant model, the adjusted odds ratio for age, sex, and ethnicity was 0.41 (95% CI, 0.21–0.80; P = 0.008) for the AG genotype and 0.11 (95%CI, 0.02–0.60; P = 0.012) for the GG genotype. MTR polymorphism showed a protective effect against arsenic-related pigmentary changes in the logistic regression model. The effect of MTR rs1805087 might be independent of arsenic metabolism and one-carbon metabolism. More studies are needed to clarify the biological function of MTR rs1805087 and its relationship with the etiology of arsenic-related pigmentary changes.
{"title":"Association of methionine synthase rs1805087 polymorphism with arsenic-related skin pigmentary changes: a population-based case–control study","authors":"Xiaoyan Huang, Yi Xiao, D. Jing, M. Shen, Li-Xia Lu","doi":"10.1097/jd9.0000000000000340","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000340","url":null,"abstract":"\u0000 \u0000 Chronic arsenic exposure causes skin lesions including skin cancers, pigmentary changes, and keratosis. Genetic polymorphism in arsenic metabolism may increase susceptibility to the development of arsenic-related skin lesions. This study was performed to determine whether arsenic metabolism-related gene variants are associated with arsenic-related pigmentary changes.\u0000 \u0000 \u0000 \u0000 This case–control study involved 189 patients with arsenic-related pigmentary changes and 103 controls. Thirty-eight polymorphisms in 10 genes determined by mass spectrometry assay served as candidate drivers of arsenic-induced pigmentary changes. Urine and plasma arsenic levels were determined by inductively coupled plasma mass spectrometry. Hair arsenic concentrations were measured by nondispersive atomic fluorescence spectrometry. Arsenic metabolites in urine were determined using high-pressure liquid chromatography hyphenated with hydride generation and inductively coupled plasma mass spectrometry. Serum folate was measured using a folate radioassay kit. Analysis of variance, nonparametric test, or the chi-square test was selected according to the data distribution. Spearman correlation analysis was used to determine the correlation between two parameters. Logistic regression was used to estimate the effect size of SNPs.\u0000 \u0000 \u0000 \u0000 The arsenic concentrations in urine, plasma, and hair and the urine arsenic species were not significantly different between cases and controls. Logistic regression revealed that among the polymorphisms, the methionine synthase (MTR) rs1805087 polymorphism showed a protective effect against arsenic-related pigmentary changes. In the codominant model, the adjusted odds ratio for age, sex, and ethnicity was 0.41 (95% CI, 0.21–0.80; P = 0.008) for the AG genotype and 0.11 (95%CI, 0.02–0.60; P = 0.012) for the GG genotype.\u0000 \u0000 \u0000 \u0000 \u0000 MTR polymorphism showed a protective effect against arsenic-related pigmentary changes in the logistic regression model. The effect of MTR rs1805087 might be independent of arsenic metabolism and one-carbon metabolism. More studies are needed to clarify the biological function of MTR rs1805087 and its relationship with the etiology of arsenic-related pigmentary changes.\u0000","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41490058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-21DOI: 10.1097/jd9.0000000000000339
B. Beatty, E. Li, Adaeze Anekwe
Beau’s lines, onychorrhexis, and psoriatic lesions of the dorsal nail plate may be missed by photographic methods, indicating a need for surface texture measurement methods that are more quantitative, sensitive, and repeatable than visual inspection or imaging. We conducted this study to evaluate the utility of surface texture measurements of cadaveric nails that can be associated with histopathological studies in the future. The nail plates of four cadaveric right pollices and halluces were cleaned and molded, cast in clear epoxy, and scanned with a Sensofar S Neox optical profilometer. A one-way analysis of variance (ANOVA) was performed to determine statistical significance of findings. Almost no differences were observed between the pollex and hallux scans, and between the distal and proximal regions. The greatest differences were found between individuals. Although lower magnification (5×) is less sensitive than higher magnification (20×), the lower magnification represented and characterized more of the dorsal nail plate. The dorsal nail plate areal roughness has a measurable range of values that may serve as a starting point for evaluating pathological findings, particularly Beau’s lines and psoriatic lesions. The sensitivity of these techniques may be especially valuable in the recognition of less severe states of these diseases that may enable the diagnosis of earlier stages of growth disruptions (Beau’s lines) or psoriasis. Such applications could be especially useful in investigations of the health of wildlife populations or vulnerable human populations with incomplete treatment records.
摄影方法可能会漏掉背甲板的Beau’s纹、甲皱和银屑病病变，这表明需要比目视检查或成像更定量、更灵敏、更可重复的表面纹理测量方法。我们进行这项研究是为了评估尸体指甲表面纹理测量的实用性，这些测量可以与未来的组织病理学研究相关联。对四具尸体右拇趾和拇趾的甲板进行清洁和成型，在透明环氧树脂中浇铸，并用Sensofar S Neox光学轮廓仪进行扫描。采用单因素方差分析（ANOVA）来确定研究结果的统计学意义。在拇趾和拇趾扫描之间以及远端和近端区域之间几乎没有观察到差异。个体之间的差异最大。尽管较低的放大倍数（5×）比较高的放大倍数更不敏感，但较低的放大率更多地代表和表征了背甲板。背甲板表面粗糙度有一个可测量的值范围，可以作为评估病理结果的起点，特别是Beau线和银屑病病变。这些技术的敏感性在识别这些疾病的较轻状态方面可能特别有价值，这些疾病可能能够诊断生长中断（Beau氏线）或银屑病的早期阶段。这种应用在调查野生动物种群或治疗记录不完整的弱势人群的健康方面尤其有用。
{"title":"Areal roughness of the dorsal nail plate","authors":"B. Beatty, E. Li, Adaeze Anekwe","doi":"10.1097/jd9.0000000000000339","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000339","url":null,"abstract":"\u0000 \u0000 Beau’s lines, onychorrhexis, and psoriatic lesions of the dorsal nail plate may be missed by photographic methods, indicating a need for surface texture measurement methods that are more quantitative, sensitive, and repeatable than visual inspection or imaging. We conducted this study to evaluate the utility of surface texture measurements of cadaveric nails that can be associated with histopathological studies in the future.\u0000 \u0000 \u0000 \u0000 The nail plates of four cadaveric right pollices and halluces were cleaned and molded, cast in clear epoxy, and scanned with a Sensofar S Neox optical profilometer. A one-way analysis of variance (ANOVA) was performed to determine statistical significance of findings.\u0000 \u0000 \u0000 \u0000 Almost no differences were observed between the pollex and hallux scans, and between the distal and proximal regions. The greatest differences were found between individuals. Although lower magnification (5×) is less sensitive than higher magnification (20×), the lower magnification represented and characterized more of the dorsal nail plate.\u0000 \u0000 \u0000 \u0000 The dorsal nail plate areal roughness has a measurable range of values that may serve as a starting point for evaluating pathological findings, particularly Beau’s lines and psoriatic lesions. The sensitivity of these techniques may be especially valuable in the recognition of less severe states of these diseases that may enable the diagnosis of earlier stages of growth disruptions (Beau’s lines) or psoriasis. Such applications could be especially useful in investigations of the health of wildlife populations or vulnerable human populations with incomplete treatment records.\u0000","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42194220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-17DOI: 10.1097/jd9.0000000000000337
Jingzhan Zhang, Pan-pan Zhang, Yuan Ding, Tingting Li, Xiao-Jing Kang
Psoriasis and vitiligo are common immune-related skin disorders. Patients are often clinically diagnosed with both diseases. However, whether psoriasis and vitiligo share common genetic factors and aberrant signal pathways that predispose patients to both diseases remains unclear. This study was performed to clarify these factors using bioinformatics analysis. Publicly available gene expression profiles for GSE109248 and GSE53552 in psoriasis and GSE75819 and GSE65127 in vitiligo from lesional and non-lesional skin tissues were downloaded from the Gene Expression Omnibus database and analyzed to identify differentially expressed genes (DEGs). Gene Ontology terms analysis, Kyoto Encyclopedia of Genes and Genomes enrichment analysis, and protein–protein interaction analysis was also performed to elucidate the molecular mechanisms. Nine overlapping DEGs were found between psoriasis and vitiligo. They are AKR1B10, CRABP1, FOXC1, GPM6B, KIT, MLPH, SOX10, TAGLN, and TUBB2B, respectively. Except for the upregulation of AKR1B10, others are downregulated. Pathway enrichment analyses revealed that these overlapping DEGs were mainly enriched in melanocyte differentiation; exocrine system development; mesenchymal cell development; stem cell differentiation and development; and neural crest cell differentiation, development, and migration. RT-qPCR was used to verify the expression of the DEGs in lesions compared to adjacent non-lesional tissues from three patients with psoriasis combined with vitiligo. Research confirmed that there were statistically significant differences among AKR1B10, FOXC1, KIT, MLPH and SOX10 in lesions compared to adjacent non-lesional tissues (P<0.05), which was consistent with the bioinformatical results. In this study, we detected potential genes and their associated enriched pathways to help understand the molecular mechanisms underlying the simultaneous occurrence of psoriasis and vitiligo.
{"title":"Identification of key pathways and genes involved in psoriasis and vitiligo using bioinformatics analysis","authors":"Jingzhan Zhang, Pan-pan Zhang, Yuan Ding, Tingting Li, Xiao-Jing Kang","doi":"10.1097/jd9.0000000000000337","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000337","url":null,"abstract":"\u0000 \u0000 Psoriasis and vitiligo are common immune-related skin disorders. Patients are often clinically diagnosed with both diseases. However, whether psoriasis and vitiligo share common genetic factors and aberrant signal pathways that predispose patients to both diseases remains unclear. This study was performed to clarify these factors using bioinformatics analysis.\u0000 \u0000 \u0000 \u0000 Publicly available gene expression profiles for GSE109248 and GSE53552 in psoriasis and GSE75819 and GSE65127 in vitiligo from lesional and non-lesional skin tissues were downloaded from the Gene Expression Omnibus database and analyzed to identify differentially expressed genes (DEGs). Gene Ontology terms analysis, Kyoto Encyclopedia of Genes and Genomes enrichment analysis, and protein–protein interaction analysis was also performed to elucidate the molecular mechanisms.\u0000 \u0000 \u0000 \u0000 Nine overlapping DEGs were found between psoriasis and vitiligo. They are AKR1B10, CRABP1, FOXC1, GPM6B, KIT, MLPH, SOX10, TAGLN, and TUBB2B, respectively. Except for the upregulation of AKR1B10, others are downregulated. Pathway enrichment analyses revealed that these overlapping DEGs were mainly enriched in melanocyte differentiation; exocrine system development; mesenchymal cell development; stem cell differentiation and development; and neural crest cell differentiation, development, and migration. RT-qPCR was used to verify the expression of the DEGs in lesions compared to adjacent non-lesional tissues from three patients with psoriasis combined with vitiligo. Research confirmed that there were statistically significant differences among AKR1B10, FOXC1, KIT, MLPH and SOX10 in lesions compared to adjacent non-lesional tissues (P<0.05), which was consistent with the bioinformatical results.\u0000 \u0000 \u0000 \u0000 In this study, we detected potential genes and their associated enriched pathways to help understand the molecular mechanisms underlying the simultaneous occurrence of psoriasis and vitiligo.\u0000","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47781832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-17DOI: 10.1097/jd9.0000000000000338
L. Xiang, Bo Yu, Jianbin Yu, Xiao-qin Wang, Gang Wang, Bao-xi Wang, R. Yin, Yong‐Bin Liu, Guo-yan Liu, Yan Yan, Ai'er Xu, Q. Sun, Cheng-Xin Li, Shanshan Li, Heng-jin Li, Bin Yang, R. Xiao, Yan Wu, Li He, Liu-Qing Chen, Xun Zhou, Zhi-zhong Zheng, Z. Yao, H. Jin, H. Gu, Xing-Hua Gao, J. Tao, Xian Jiang, Wei-hui Zeng, W. Lai, X. Man, Q. Ju
Aminolevulinic acid-based photodynamic therapy (ALA⁃PDT) is a safe and effective physical therapy for acne vulgaris that is widely used in clinical practice. To further standardize the clinical application of ALA⁃PDT in the treatment of acne, we created this updated consensus based on the 2011 version of the consensus on ALA⁃PDT for the treatment of acne vulgaris. In this document, we summarize the mechanisms of action of ALA-PDT and provide practical standards for patient selection, treatment parameters, administration procedures, and management of adverse reactions. Our aim was to provide guidance and treatment regimens for using ALA-PDT for acne vulgaris in clinical practice.
{"title":"Expert consensus on the clinical application of aminolevulinic acid-based photodynamic therapy for acne vulgaris (2022)#","authors":"L. Xiang, Bo Yu, Jianbin Yu, Xiao-qin Wang, Gang Wang, Bao-xi Wang, R. Yin, Yong‐Bin Liu, Guo-yan Liu, Yan Yan, Ai'er Xu, Q. Sun, Cheng-Xin Li, Shanshan Li, Heng-jin Li, Bin Yang, R. Xiao, Yan Wu, Li He, Liu-Qing Chen, Xun Zhou, Zhi-zhong Zheng, Z. Yao, H. Jin, H. Gu, Xing-Hua Gao, J. Tao, Xian Jiang, Wei-hui Zeng, W. Lai, X. Man, Q. Ju","doi":"10.1097/jd9.0000000000000338","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000338","url":null,"abstract":"Aminolevulinic acid-based photodynamic therapy (ALA⁃PDT) is a safe and effective physical therapy for acne vulgaris that is widely used in clinical practice. To further standardize the clinical application of ALA⁃PDT in the treatment of acne, we created this updated consensus based on the 2011 version of the consensus on ALA⁃PDT for the treatment of acne vulgaris. In this document, we summarize the mechanisms of action of ALA-PDT and provide practical standards for patient selection, treatment parameters, administration procedures, and management of adverse reactions. Our aim was to provide guidance and treatment regimens for using ALA-PDT for acne vulgaris in clinical practice.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42789658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.1097/jd9.0000000000000336
Qing-Jie Hu, Jing-jing Chen, X. Yao
Acquired reactive perforating collagenosis(ARPC) is a rare dermatosis that usually associated with systemic disease. The associations, characteristics and treatment rigemen of ARPC are not well understood.This study was performed to retrospectively evaluate the diagnosis and treatment statuses of acquired reactive perforating collagenosis (ARPC). A systematic review of the PubMed, Embase, and Scopus databases was independently performed by two reviewers. Data were extracted and qualitatively analyzed. The quality of the articles was assessed by using the Newcastle–Ottawa scale. The data are described in the manuscript. The study was registered with PROSPERO, CRD 42023448576. In total, 189 patients (98 women, 91 men) in 124 studies were analyzed. Their mean age was 57.31 ± 15.21 years. A total of 88.89% (n = 168) of the patients had one or more systemic diseases, of which 57.67% (n = 109) had diabetes mellitus, 29.10% (n = 55) had chronic renal failure, 25.93% (n = 49) had hypertension, and 13.76% had malignancy (n = 26). The most frequently affected area was the lower extremities (72.49%, n = 137), followed by the trunk (70.37%, n = 133) and the upper extremities (63.49%, n = 120). One hundred sixty (84.66%) patients had pruritus, and 32.80% (n = 62) of them were positive for the Koebner phenomenon. Oral antihistamines and topical steroids were the most common treatments in this study, followed by narrow-band ultraviolet B therapy and allopurinol. Management of concomitant systemic diseases also resulted in improvement of ARPC. In this review, ARPC was frequently associated with systemic diseases, especially diabetes mellitus, renal failure, hypertension, and malignancy. The lower extremities and trunk were the most frequently affected areas, and pruritus usually appeared. Antihistamines and topical steroids were the most commonly used treatments, and we recommend narrow-band ultraviolet B therapy as the first-line treatment. Management of systemic diseases and relief of pruritus should be considered simultaneously.
{"title":"Systematic review and meta-analysis Literature-based Clinical Retrospective Analysis of Acquired Reactive Perforating Collagenosis","authors":"Qing-Jie Hu, Jing-jing Chen, X. Yao","doi":"10.1097/jd9.0000000000000336","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000336","url":null,"abstract":"\u0000 \u0000 Acquired reactive perforating collagenosis(ARPC) is a rare dermatosis that usually associated with systemic disease. The associations, characteristics and treatment rigemen of ARPC are not well understood.This study was performed to retrospectively evaluate the diagnosis and treatment statuses of acquired reactive perforating collagenosis (ARPC).\u0000 \u0000 \u0000 \u0000 A systematic review of the PubMed, Embase, and Scopus databases was independently performed by two reviewers. Data were extracted and qualitatively analyzed. The quality of the articles was assessed by using the Newcastle–Ottawa scale. The data are described in the manuscript. The study was registered with PROSPERO, CRD 42023448576.\u0000 \u0000 \u0000 \u0000 In total, 189 patients (98 women, 91 men) in 124 studies were analyzed. Their mean age was 57.31 ± 15.21 years. A total of 88.89% (n = 168) of the patients had one or more systemic diseases, of which 57.67% (n = 109) had diabetes mellitus, 29.10% (n = 55) had chronic renal failure, 25.93% (n = 49) had hypertension, and 13.76% had malignancy (n = 26). The most frequently affected area was the lower extremities (72.49%, n = 137), followed by the trunk (70.37%, n = 133) and the upper extremities (63.49%, n = 120). One hundred sixty (84.66%) patients had pruritus, and 32.80% (n = 62) of them were positive for the Koebner phenomenon. Oral antihistamines and topical steroids were the most common treatments in this study, followed by narrow-band ultraviolet B therapy and allopurinol. Management of concomitant systemic diseases also resulted in improvement of ARPC.\u0000 \u0000 \u0000 \u0000 In this review, ARPC was frequently associated with systemic diseases, especially diabetes mellitus, renal failure, hypertension, and malignancy. The lower extremities and trunk were the most frequently affected areas, and pruritus usually appeared. Antihistamines and topical steroids were the most commonly used treatments, and we recommend narrow-band ultraviolet B therapy as the first-line treatment. Management of systemic diseases and relief of pruritus should be considered simultaneously.\u0000","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46862744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-02DOI: 10.1097/jd9.0000000000000334
Ming-Yang Wu, Xu Yao
The skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers. In this review, we discuss the host–microbiota interactions in barrier maintenance and disruption, implications for skin disorders such as atopic dermatitis, psoriasis, and rosacea, and the latest strategies for targeting the skin microbiota to improve the skin barrier.
{"title":"Skin Microbiota and the Skin Barrier","authors":"Ming-Yang Wu, Xu Yao","doi":"10.1097/jd9.0000000000000334","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000334","url":null,"abstract":"The skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers. In this review, we discuss the host–microbiota interactions in barrier maintenance and disruption, implications for skin disorders such as atopic dermatitis, psoriasis, and rosacea, and the latest strategies for targeting the skin microbiota to improve the skin barrier.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43462747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-02DOI: 10.1097/jd9.0000000000000335
F. Venturi, B. Melotti, M. Lambertini, A. Alessandrini, A. Ardizzoni, E. Dika
Immune-related adverse events induced by immune checkpoint inhibitors are quite common. Cutaneous lichenoid immune-related adverse events are among the most frequent. However, oral lichenoid adverse reactions are extremely rare. We herein describe a patient who was treated with pembrolizumab for metastatic lung cancer and developed an erosive oral lichenoid reaction induced by immunotherapy. An 87-year-old man treated with pembrolizumab for metastatic lung adenocarcinoma (stage IVa based on AJCC 2018) developed multifocal erosions of the oral mucosa mainly located on the buccal mucosa, palate, and inner portion of the lips with multiple small, irregular, hyperkeratotic areas. Histopathological examination showed epithelial necrosis and a dense band-like layer of an inflammatory infiltrate of lymphocytes and histiocytes within the upper dermis. Direct immunofluorescence was negative for both IgG and C3. A diagnosis of erosive oral lichenoid reaction of the mucosa induced by immunotherapy was established. Given the severity of the condition, pembrolizumab treatment was withheld and concomitant topical and systemic steroids were started. After 1 month, the drug-related toxicity was ameliorated and immunotherapy was re-introduced. Only one other case of pembrolizumab-induced erosive lichen planus of the oral mucosa has been described to date. Previously reported drug-induced lichenoid rashes were mainly localized on the skin. Clinically, the main differential diagnoses of lichenoid erosive lesions are bullous immune-related disorders and should be excluded. In our patient, histological examination combined with negative results of both direct immunofluorescence and enzyme-linked immunosorbent assays confirmed the diagnosis of erosive lichenoid drug reaction. Clinicians should be aware of lichenoid involvement of the oral mucosa because related pain and food intake difficulties may seriously compromise treatment compliance. Prompt treatment of oral drug-related reactions may prevent interruption of immunotherapy and improve patients’ quality of life.
{"title":"Pembrolizumab-induced erosive lichenoid reaction in a patient with metastatic lung adenocarcinoma: A case report","authors":"F. Venturi, B. Melotti, M. Lambertini, A. Alessandrini, A. Ardizzoni, E. Dika","doi":"10.1097/jd9.0000000000000335","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000335","url":null,"abstract":"\u0000 \u0000 Immune-related adverse events induced by immune checkpoint inhibitors are quite common. Cutaneous lichenoid immune-related adverse events are among the most frequent. However, oral lichenoid adverse reactions are extremely rare.\u0000 We herein describe a patient who was treated with pembrolizumab for metastatic lung cancer and developed an erosive oral lichenoid reaction induced by immunotherapy.\u0000 \u0000 \u0000 \u0000 An 87-year-old man treated with pembrolizumab for metastatic lung adenocarcinoma (stage IVa based on AJCC 2018) developed multifocal erosions of the oral mucosa mainly located on the buccal mucosa, palate, and inner portion of the lips with multiple small, irregular, hyperkeratotic areas. Histopathological examination showed epithelial necrosis and a dense band-like layer of an inflammatory infiltrate of lymphocytes and histiocytes within the upper dermis. Direct immunofluorescence was negative for both IgG and C3. A diagnosis of erosive oral lichenoid reaction of the mucosa induced by immunotherapy was established. Given the severity of the condition, pembrolizumab treatment was withheld and concomitant topical and systemic steroids were started. After 1 month, the drug-related toxicity was ameliorated and immunotherapy was re-introduced.\u0000 \u0000 \u0000 \u0000 Only one other case of pembrolizumab-induced erosive lichen planus of the oral mucosa has been described to date. Previously reported drug-induced lichenoid rashes were mainly localized on the skin. Clinically, the main differential diagnoses of lichenoid erosive lesions are bullous immune-related disorders and should be excluded. In our patient, histological examination combined with negative results of both direct immunofluorescence and enzyme-linked immunosorbent assays confirmed the diagnosis of erosive lichenoid drug reaction.\u0000 \u0000 \u0000 \u0000 Clinicians should be aware of lichenoid involvement of the oral mucosa because related pain and food intake difficulties may seriously compromise treatment compliance. Prompt treatment of oral drug-related reactions may prevent interruption of immunotherapy and improve patients’ quality of life.\u0000","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46291271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.1097/jd9.0000000000000333
K. Andrew
{"title":"The role of Interleukin-6 in Pemphigus Vulgaris","authors":"K. Andrew","doi":"10.1097/jd9.0000000000000333","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000333","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46408923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.1097/jd9.0000000000000332
R. Lim, Nicole A. Negbenebor, E. Lin, Sara D. Ragi, L. Robinson-Bostom, Cathy M Massoud
Cutaneous pyoderma gangrenosum (PG) is an ulcerating autoinflammatory neutrophilic dermatosis often associated with inflammatory bowel disease, hematologic diseases, or arthritis. PG secondary to systemic medications is less commonly reported. PG is a diagnosis of exclusion that requires investigation of other causes of cutaneous ulcers prior to final diagnosis. We herein describe a case of cocaine-induced PG with atypical features (recurrent ulcerations limited to the lower extremities and perinuclear anti-neutrophil cytoplasmic antibody negativity) following years of abstinence from cocaine. PG is a rare autoinflammatory neutrophilic dermatosis and a diagnosis of exclusion because of its nonspecific clinical presentation. Drug-induced PG is less common but presents an opportunity to further research the pathogenesis of PG. This unusual case reinforces that drug-induced PG may have non-classical features and may serve as an indicator of past or present substance abuse, allowing for patient education and counseling.
{"title":"Cocaine-induced pyoderma gangrenosum with negative anti-neutrophil cytoplasmic antibodies: A case report","authors":"R. Lim, Nicole A. Negbenebor, E. Lin, Sara D. Ragi, L. Robinson-Bostom, Cathy M Massoud","doi":"10.1097/jd9.0000000000000332","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000332","url":null,"abstract":"\u0000 \u0000 Cutaneous pyoderma gangrenosum (PG) is an ulcerating autoinflammatory neutrophilic dermatosis often associated with inflammatory bowel disease, hematologic diseases, or arthritis. PG secondary to systemic medications is less commonly reported. PG is a diagnosis of exclusion that requires investigation of other causes of cutaneous ulcers prior to final diagnosis.\u0000 \u0000 \u0000 \u0000 We herein describe a case of cocaine-induced PG with atypical features (recurrent ulcerations limited to the lower extremities and perinuclear anti-neutrophil cytoplasmic antibody negativity) following years of abstinence from cocaine.\u0000 \u0000 \u0000 \u0000 PG is a rare autoinflammatory neutrophilic dermatosis and a diagnosis of exclusion because of its nonspecific clinical presentation. Drug-induced PG is less common but presents an opportunity to further research the pathogenesis of PG.\u0000 \u0000 \u0000 \u0000 This unusual case reinforces that drug-induced PG may have non-classical features and may serve as an indicator of past or present substance abuse, allowing for patient education and counseling.\u0000","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.1097/jd9.0000000000000329
{"title":"Dermatoscopy in Vulvar Basal Cell Carcinoma: Case Report: Erratum","authors":"","doi":"10.1097/jd9.0000000000000329","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000329","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41630631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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