Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-1-30-32
L. Kaliuzhna
The goal is to demonstrate a clinical case of serpiginous perforating elastosis for better awareness of doctors.The hallmark of the perforating diseases is the transepidermal elimination of degraded dermal componenrs. The material extruded may represent abnormally constituded collagen, elastic fibers or other matrix components. Four classical forms of primary perforating dermatosis are described: reactive perforating collagenosis, Kyrle’s disease, perforating folliculitis and elastosis perforans serpiginosa.
{"title":"THE APPROACH TO DIAGNOSIS OF PERFORATING ELASTOSIS SERPIGINOSA","authors":"L. Kaliuzhna","doi":"10.33743/2308-1066-2023-1-30-32","DOIUrl":"https://doi.org/10.33743/2308-1066-2023-1-30-32","url":null,"abstract":"The goal is to demonstrate a clinical case of serpiginous perforating elastosis for better awareness of doctors.The hallmark of the perforating diseases is the transepidermal elimination of degraded dermal componenrs. The material extruded may represent abnormally constituded collagen, elastic fibers or other matrix components. Four classical forms of primary perforating dermatosis are described: reactive perforating collagenosis, Kyrle’s disease, perforating folliculitis and elastosis perforans serpiginosa.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75790681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/1066-2023-1-7-10
M. Vitkovska
Based on a review of the scientific literature, the main data on the history of human coronavirus infections are given. Modern views on the etiology of COVID‑19, its epidemiology, pathogenesis, main clinical variants and their manifestations are described. The goal is to increase the awareness of patients, doctors and medical personnel about the epidemic of the new viral disease COVID‑19.
{"title":"COVID-19: CHARACTERISTICS, THERAPY AND CURRENT ISSUES","authors":"M. Vitkovska","doi":"10.33743/1066-2023-1-7-10","DOIUrl":"https://doi.org/10.33743/1066-2023-1-7-10","url":null,"abstract":"Based on a review of the scientific literature, the main data on the history of human coronavirus infections are given. Modern views on the etiology of COVID‑19, its epidemiology, pathogenesis, main clinical variants and their manifestations are described. The goal is to increase the awareness of patients, doctors and medical personnel about the epidemic of the new viral disease COVID‑19.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"81 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83155635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-2-7-10
Y. Kutasevych, S. Dzhoraieva, M. Lyapunov, E. Khoroshun, M.S. Birukov, V. Kupriyanchuk, S. Shipilov, I. Mashtakova, V. Goncharenko, O. Ivantsova
The problems of treating victims with gunshot wounds are determined by the issue of prevention and treatment of purulent complications, because wounds received during hostilities are a priori infected, and the most dangerous complication of wounds is the development of purulent infection. The purpose of the research is to study the peculiarities of the microbial landscape of combat wounds and the antimicrobial activity of certain drugs in relation to extensively resistant and polyresistant microbial agents in order to develop algorithms in external therapy within the framework of complex treatment of these injuries Materials and methods. The data of microbiological studies of 32 victims with gunshot wounds were used in the work. Research results: Based on the results of monitoring the causative agents of purulent-inflammatory complications of wound injuries, a range of leading types of microorganisms was established: K. pneumoniae E. faecalis, S. haemolyticus, P. aeruginosa, E. coli. The isolation of flora resistant to most antibiotics from wounds dictates the need to change the strategy of infection control with strengthening measures to prevent nosocomial transmission and should be taken into account in the process of prescribing antibiotic therapy. Conclusion. The obtained results of the pilot study demonstrate the microbiological effectiveness of dioxidin, partially mupirocin and fusidin, which can be used in the complex treatment of microbial complications of wound injuries and the development of optimal tactics for providing medical care and treatment of the wounded, and can also serve as a basis for the development of a method of complex treatment for certain phases wound process, which allow simultaneous influence on several factors of pathogenesis.
{"title":"COMPARATIVE ASSESSMENT OF THE SENSITIVITY OF CAUSES OF WOUND INFECTIONS TO TOPICAL ANTIBACTERIAL DRUGS","authors":"Y. Kutasevych, S. Dzhoraieva, M. Lyapunov, E. Khoroshun, M.S. Birukov, V. Kupriyanchuk, S. Shipilov, I. Mashtakova, V. Goncharenko, O. Ivantsova","doi":"10.33743/2308-1066-2023-2-7-10","DOIUrl":"https://doi.org/10.33743/2308-1066-2023-2-7-10","url":null,"abstract":"The problems of treating victims with gunshot wounds are determined by the issue of prevention and treatment of purulent complications, because wounds received during hostilities are a priori infected, and the most dangerous complication of wounds is the development of purulent infection. The purpose of the research is to study the peculiarities of the microbial landscape of combat wounds and the antimicrobial activity of certain drugs in relation to extensively resistant and polyresistant microbial agents in order to develop algorithms in external therapy within the framework of complex treatment of these injuries Materials and methods. The data of microbiological studies of 32 victims with gunshot wounds were used in the work. Research results: Based on the results of monitoring the causative agents of purulent-inflammatory complications of wound injuries, a range of leading types of microorganisms was established: K. pneumoniae E. faecalis, S. haemolyticus, P. aeruginosa, E. coli. The isolation of flora resistant to most antibiotics from wounds dictates the need to change the strategy of infection control with strengthening measures to prevent nosocomial transmission and should be taken into account in the process of prescribing antibiotic therapy. Conclusion. The obtained results of the pilot study demonstrate the microbiological effectiveness of dioxidin, partially mupirocin and fusidin, which can be used in the complex treatment of microbial complications of wound injuries and the development of optimal tactics for providing medical care and treatment of the wounded, and can also serve as a basis for the development of a method of complex treatment for certain phases wound process, which allow simultaneous influence on several factors of pathogenesis.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84202639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-2-27-31
O. I. Oliinyk
The aim of the work was to evaluate the impact of immunosuppressive therapy with glucocorticoids and cytostatic drugs on the course and prognosis of chronic dermatoses. Materials and methods. 192 patients with severe chronic dermatoses (psoriasis – 169 people, pemphigus vulgaris – 23) were involved in the study. The examined cohort included 90 females (46.9%) and 102 males (53.1%), as well as a control group of 17 clinically healthy individuals. 67 patients with psoriasis (34.9%) previously received immunosuppressive therapy (21 (31.3%) – cytostatic immunosuppressants + systemic glucocorticosteroids, 16 (23.9%) – systemic glucocorticosteroids, 30 (44.8%) – cytostatic immunosuppressants). All patients with pemphigus vulgaris previously received immunosuppressive therapy, and 13 patients (56.5%) received systemic glucocorticosteroids, 10 (43.5%) received a combination of systemic glucocorticosteroids and cytostatic immunosuppressants. The results. The frequency of infectious bacterial complications in different groups of patients with psoriasis was distributed as follows: in 37.5% of patients treated with systemic glucocorticosteroids and 19.0% of patients with a combination of systemic glucocorticosteroids and cytostatic immunosuppressants, on the other hand, 3.9% did not prevail among patients who received immunosuppressive therapy. And in patients with pemphigus vulgaris, we noted manifestations of pyoderma in almost all patients – in 92.3% of patients receiving systemic glucocorticosteroids, and in 70% of patients receiving combined therapy of systemic glucocorticosteroids and cytostatic immunosuppressants. Conclusions. Available treatment methods lead to an increase in the torpid course, the development of complications as a result of treatment, and a shortening of the remission period. It is necessary to develop and improve methods of therapy and prevention of its complications.
{"title":"FEATURES OF THE COURSE OF CHRONIC DERMATOSES IN PATIENTS WHO RECEIVED IMMUNOSUPPRESSIVE THERAPY","authors":"O. I. Oliinyk","doi":"10.33743/2308-1066-2023-2-27-31","DOIUrl":"https://doi.org/10.33743/2308-1066-2023-2-27-31","url":null,"abstract":"The aim of the work was to evaluate the impact of immunosuppressive therapy with glucocorticoids and cytostatic drugs on the course and prognosis of chronic dermatoses. Materials and methods. 192 patients with severe chronic dermatoses (psoriasis – 169 people, pemphigus vulgaris – 23) were involved in the study. The examined cohort included 90 females (46.9%) and 102 males (53.1%), as well as a control group of 17 clinically healthy individuals. 67 patients with psoriasis (34.9%) previously received immunosuppressive therapy (21 (31.3%) – cytostatic immunosuppressants + systemic glucocorticosteroids, 16 (23.9%) – systemic glucocorticosteroids, 30 (44.8%) – cytostatic immunosuppressants). All patients with pemphigus vulgaris previously received immunosuppressive therapy, and 13 patients (56.5%) received systemic glucocorticosteroids, 10 (43.5%) received a combination of systemic glucocorticosteroids and cytostatic immunosuppressants. The results. The frequency of infectious bacterial complications in different groups of patients with psoriasis was distributed as follows: in 37.5% of patients treated with systemic glucocorticosteroids and 19.0% of patients with a combination of systemic glucocorticosteroids and cytostatic immunosuppressants, on the other hand, 3.9% did not prevail among patients who received immunosuppressive therapy. And in patients with pemphigus vulgaris, we noted manifestations of pyoderma in almost all patients – in 92.3% of patients receiving systemic glucocorticosteroids, and in 70% of patients receiving combined therapy of systemic glucocorticosteroids and cytostatic immunosuppressants. Conclusions. Available treatment methods lead to an increase in the torpid course, the development of complications as a result of treatment, and a shortening of the remission period. It is necessary to develop and improve methods of therapy and prevention of its complications.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77621357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-1-20-24
V. Tsepkolenko, K. Karpenko
Vitiligo is a chronic acquired disorder of skin pigmentation, characterized by the presence of sharply limited depigmented areas of the skin as a result of the progressive loss of melanocytes. The purpose of the work: increasing the effectiveness of treatment of patients with vitiligo by shortening the treatment period, ensuring the stability of results and reducing the number of complications with combined methods of treatment of a stable form of vitiligo with the use of cultured melanocytes and keratinocytes compared to methods approved by European standards and domestic orders. Study object and methods: 107 vitiligo patients aged 19 to 65 were under our observation. Depending on the method of treatment, the patients were randomly selected into two representative groups: the main group, which received treatment according to the developed method, and the comparison group, which received traditional treatment. When evaluating the results of treatment in examined patients 8 and 16 weeks after the start of therapy, more pronounced positive dynamics were found in patients of the main group, whose complex therapy included melanocyte-keratinocyte suspension (MCS) and automesoconcentrate (AMK). Conclusions: the analysis of the results of treatment of patients with vitiligo proved not only good tolerance, but also high efficiency of treatment when using, along with traditional therapy, cellular technologies.
{"title":"PHOTOTHERAPY AND CELLULAR TECHNOLOGIES APPLICATION IN COMPLEX VITILIGO THERAPY. OWN EXPERIENCE","authors":"V. Tsepkolenko, K. Karpenko","doi":"10.33743/2308-1066-2023-1-20-24","DOIUrl":"https://doi.org/10.33743/2308-1066-2023-1-20-24","url":null,"abstract":"Vitiligo is a chronic acquired disorder of skin pigmentation, characterized by the presence of sharply limited depigmented areas of the skin as a result of the progressive loss of melanocytes. The purpose of the work: increasing the effectiveness of treatment of patients with vitiligo by shortening the treatment period, ensuring the stability of results and reducing the number of complications with combined methods of treatment of a stable form of vitiligo with the use of cultured melanocytes and keratinocytes compared to methods approved by European standards and domestic orders. Study object and methods: 107 vitiligo patients aged 19 to 65 were under our observation. Depending on the method of treatment, the patients were randomly selected into two representative groups: the main group, which received treatment according to the developed method, and the comparison group, which received traditional treatment. When evaluating the results of treatment in examined patients 8 and 16 weeks after the start of therapy, more pronounced positive dynamics were found in patients of the main group, whose complex therapy included melanocyte-keratinocyte suspension (MCS) and automesoconcentrate (AMK). Conclusions: the analysis of the results of treatment of patients with vitiligo proved not only good tolerance, but also high efficiency of treatment when using, along with traditional therapy, cellular technologies.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78777718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-2-11-14
Y. Kutasevych, I. Oliinyk, K.H. Suprun, O. Sokol
The work provides justification for the need to improve the diagnosing methods of the life activity of fungi in the sanogenesis process of onychomycosis. The proprietary technique based on the detection of complementary DNA by reverse transcription of the polymerase chain reaction is proposed. The algorithm for evaluating the elimination of onychomycosis pathogens has been given.
{"title":"DEVELOPMENT OF THE METHOD FOR ASSESSING THE VIABILITY OF FUNGI USING THE POLYMERASE CHAIN REACTION","authors":"Y. Kutasevych, I. Oliinyk, K.H. Suprun, O. Sokol","doi":"10.33743/2308-1066-2023-2-11-14","DOIUrl":"https://doi.org/10.33743/2308-1066-2023-2-11-14","url":null,"abstract":"The work provides justification for the need to improve the diagnosing methods of the life activity of fungi in the sanogenesis process of onychomycosis. The proprietary technique based on the detection of complementary DNA by reverse transcription of the polymerase chain reaction is proposed. The algorithm for evaluating the elimination of onychomycosis pathogens has been given.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74963869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-2-15-18
I. Ziuban
The purpose of the work is to increase the effectiveness of treatment of patients with atopic dermatitis by improving phototherapy methods as part of complex therapy. Materials and methods. 48 patients with atopic dermatitis, who were divided into two groups of 24 people each, were included in the study. I group of patients received basic therapy using the cream with ceramides and phototherapy with broadband ultraviolet radiation. Patients included in the II group received basic therapy using the cream with ceramides and narrow-spectrum phototherapy UVB311 nm. Results. In patients of the I group the level of hydration before treatment was (24.3 ± 2.4) conventional units and did not differ by this indicator in the II group – (21.4 ± 2.3) conventional units, which characterized the skin before treatment in both groups as dehydrated. The moisture of the epidermis after 15 procedures of the complex of medical measures improved to the normal level and amounted to (28.1 ± 1.4) conventional units in the I group, and in the II group – (34.7 ± 1.3) conventional units. Thus, patients who received baseline therapy and narrow-spectrum UVB311 nm phototherapy had better rates of skin hydration recovery compared to patients who did not receive it. Conclusions. The use of narrow-spectrum UVB311 nm phototherapy has been proven to be more effective, including in patients with a severe form of atopic dermatitis, compared to the use of broadband phototherapy.
{"title":"DYNAMICS OF SKIN MOISTURE INDICATORS AS A RESULT USE OF UVB THERAPY AS PART OF THE COMPLEX TREATMENT OF PATIENTS WITH ATOPIC DERMATITIS","authors":"I. Ziuban","doi":"10.33743/2308-1066-2023-2-15-18","DOIUrl":"https://doi.org/10.33743/2308-1066-2023-2-15-18","url":null,"abstract":"The purpose of the work is to increase the effectiveness of treatment of patients with atopic dermatitis by improving phototherapy methods as part of complex therapy. Materials and methods. 48 patients with atopic dermatitis, who were divided into two groups of 24 people each, were included in the study. I group of patients received basic therapy using the cream with ceramides and phototherapy with broadband ultraviolet radiation. Patients included in the II group received basic therapy using the cream with ceramides and narrow-spectrum phototherapy UVB311 nm. Results. In patients of the I group the level of hydration before treatment was (24.3 ± 2.4) conventional units and did not differ by this indicator in the II group – (21.4 ± 2.3) conventional units, which characterized the skin before treatment in both groups as dehydrated. The moisture of the epidermis after 15 procedures of the complex of medical measures improved to the normal level and amounted to (28.1 ± 1.4) conventional units in the I group, and in the II group – (34.7 ± 1.3) conventional units. Thus, patients who received baseline therapy and narrow-spectrum UVB311 nm phototherapy had better rates of skin hydration recovery compared to patients who did not receive it. Conclusions. The use of narrow-spectrum UVB311 nm phototherapy has been proven to be more effective, including in patients with a severe form of atopic dermatitis, compared to the use of broadband phototherapy.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87274685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-1-14-19
Y. Kutasevych, I. Ziuban, S. Dzhoraeva
Atopic dermatitis (AD) is a hereditary disease, the degree of clinical manifestations of which largely depends on the influence of environmental factors and the body’s resistance. The modern pathogenetic model of AD can be represented as a chain, the genetic links of which are considered to be: a set of predisposition genes, a reduced skin barrier function, a violation of innate immunity, which are joined by external factors and features of the adaptive immune response. The most significant genetically determined disorders in this disease are changes in the immune system and skin barrier, the dysfunction of which is a favorable background for the development of AD. The second group of factors that influence the development of the disease is the triggers of the external environment: various chemical substances, food and medicinal irritants, infectious agents, etc. Bacteriological research data indicate high rates of colonization density of lesions and conditionally intact skin areas of AD patients with moderately severe and severe severity [(6.5±0.2) lg CFU/cm2 and (6.3±0.1) lg CFU/cm2 and (6.9±0.2) lg CFU/cm2 and (6.8±0.2) lg CFU/cm2, respectively, against 4.1±0.1 lg CFU/cm2 on the skin of healthy persons, p ≤ 0.05]. When using narrow-spectrum UVB therapy as part of complex treatment of severe forms of AD, regression of clinical signs of pyococcal infection was noted in 72.2% of people. Clinical remission was achieved in 27.7% of patients, significant improvement in 55.5%, improvement in 16.7%.
特应性皮炎(AD)是一种遗传性疾病，其临床表现的程度在很大程度上取决于环境因素的影响和机体的抵抗力。阿尔茨海默病的现代发病模式可以用一个链条来表示，其遗传环节被认为是:一组易感基因、皮肤屏障功能降低、先天免疫受到侵犯，这些因素与外部因素和适应性免疫反应的特征相连接。该疾病中最重要的遗传决定疾病是免疫系统和皮肤屏障的改变，其功能障碍是AD发展的有利背景。影响疾病发展的第二组因素是外部环境的触发因素:各种化学物质、食物和药物刺激物、传染因子等。细菌学研究数据表明，中度和重度AD患者病变和条件完整皮肤区域的定植密度较高[分别为(6.5±0.2)lg CFU/cm2和(6.3±0.1)lg CFU/cm2和(6.9±0.2)lg CFU/cm2和(6.8±0.2)lg CFU/cm2，健康人皮肤为4.1±0.1 lg CFU/cm2, p≤0.05]。当使用窄谱UVB治疗作为严重AD的综合治疗的一部分时，72.2%的患者脓球菌感染的临床症状消退。临床缓解率为27.7%，显著改善率为55.5%，改善率为16.7%。
{"title":"EVALUATION OF THE EFFICIENCY OF THE USE OF UVB THERAPY AS PART OF THE COMPLEX TREATMENT OF PATIENTS WITH ATOPIC DERMATITIS TAKING INTO ACCOUNT THE STATE OF SKIN MICROBIOCENOSIS","authors":"Y. Kutasevych, I. Ziuban, S. Dzhoraeva","doi":"10.33743/2308-1066-2023-1-14-19","DOIUrl":"https://doi.org/10.33743/2308-1066-2023-1-14-19","url":null,"abstract":"Atopic dermatitis (AD) is a hereditary disease, the degree of clinical manifestations of which largely depends on the influence of environmental factors and the body’s resistance. The modern pathogenetic model of AD can be represented as a chain, the genetic links of which are considered to be: a set of predisposition genes, a reduced skin barrier function, a violation of innate immunity, which are joined by external factors and features of the adaptive immune response. The most significant genetically determined disorders in this disease are changes in the immune system and skin barrier, the dysfunction of which is a favorable background for the development of AD. The second group of factors that influence the development of the disease is the triggers of the external environment: various chemical substances, food and medicinal irritants, infectious agents, etc. Bacteriological research data indicate high rates of colonization density of lesions and conditionally intact skin areas of AD patients with moderately severe and severe severity [(6.5±0.2) lg CFU/cm2 and (6.3±0.1) lg CFU/cm2 and (6.9±0.2) lg CFU/cm2 and (6.8±0.2) lg CFU/cm2, respectively, against 4.1±0.1 lg CFU/cm2 on the skin of healthy persons, p ≤ 0.05]. When using narrow-spectrum UVB therapy as part of complex treatment of severe forms of AD, regression of clinical signs of pyococcal infection was noted in 72.2% of people. Clinical remission was achieved in 27.7% of patients, significant improvement in 55.5%, improvement in 16.7%.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80381090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-2-23-26
K. Lysenko
The purpose of the study is to analyze the effect of drugs with immunomodulatory effect on the changed indicators of the immune system of patients with idiopathic eczema (IE) and microbial eczema (ME). Materials and methods. 43 patients with chronic eczema (19 with idiopathic and 24 with microbial) aged 18–63 were examined. Eczema severity was assessed using the EASI. The immunological study carried out before and after treatment included the determination of the subpopulation composition of blood lymphocytes (CD3+, CD4+ and CD8+) by flow cytofluorimetry, interleukins (IL)- 4, –10, –17 and interferon (IFN) γ, lactoferrin (LF) and human β-defensin 2 (hBD2) by immunoenzymatic method using appropriate commercial test systems. The innate immune system was assessed by the phagocytic index (PhI), phagocytic number (PhN) and phagocytosis completion index (PhCI). Patients with IE against the background of traditional therapy additionally received cholecalciferol (vitamin D3), ME – glucosaminylmuramylpentapeptide (GMPP), than cholecalciferol. The duration of HMPP administration and the dose of vitamin D3 depended on the severity of the dermatosis. Results and conclusions. The developed therapy contributed to regression of clinical manifestations, reduction of EASI. With IE and ME, clinical remission was achieved in 31.6% and 29.2%, significant improvement in 57.9% and 54.1%, and improvement in 10.5% and 16.7% of patients, respectively. Under the influence of immunomodulatory agents, it was possible to normalize most indicators of immunity, except for some parameters of innate immunity (PhCI and LF in ME), the level of IL (IL-17 in IE).
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Pub Date : 2023-01-01DOI: 10.33743/2308-1066-2023-1-33-34
I. Oliinyk, I. Mashtakova
The case of generalized local scleroderma with the positive effect as a result of the therapy is described. The goal is to evaluate the therapeutic effectiveness of complex treatment using antifibrotic agents in a clinical case of generalized focal scleroderma.
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