Pub Date : 2022-10-12DOI: 10.1097/jd9.0000000000000257
Swapnil D. Shah, B. Ankad, Tanuja Rajagopal
{"title":"Anagen effluvium due to azathioprine in a patient with normal thiopurine S-methyltransferase levels: A videodermoscopic analysis","authors":"Swapnil D. Shah, B. Ankad, Tanuja Rajagopal","doi":"10.1097/jd9.0000000000000257","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000257","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48007275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical application of CLSM, dermoscope and Wood’s lamp in diagnosis and differential diagnosis of five hypopigmentation disorders","authors":"Yu Lu, Xiao Wan, Quansheng Lu, Chao Sun, Shanrong Lv, Yizhi Li, Guan Jiang","doi":"10.1097/jd9.0000000000000254","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000254","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47050364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-11DOI: 10.1097/JD9.0000000000000260
Xiaojing Xing, Song Wang, Anqi Li, Zihang Li, Biwen Lin
Objective: The skin manifestations of dermatomyositis (DM) are complex and diverse, with some rashes having diagnostic significance, while others have a certain suggestive effect on the patient’s condition, visceral damage, and prognosis. This case-cohort study was performed to investigate the skin manifestations of 205 adult inpatients with DM. We then analyzed the association between the clinical characteristics and panniculitis in adult patients with DM. Methods: This study was conducted at the First Medical Center of PLA General Hospital, Beijing, China from March 1, 2016 to December 30, 2020 with follow-up until December 31, 2021. This case-cohort study involved 205 eligible participants with DM who met the criteria for idiopathic inflammatory myopathy. Clinical data, cutaneous manifestations, and lesion locations were screened and analyzed. Serum samples were collected, and immunoblotting was used to detect 16 types of myositis-specific antibodies and myositis-associated antibodies. Results: The results showed that 16 (7.8%) of the 205 adult patients with DM had panniculitis. The panniculitis was mainly distributed in the subcutaneous fat of the abdomen, buttocks, and thighs. This condition was often accompanied by skin ulcers, atrophic scars, and calcinosis. Moreover, 9 (72.7%) of the 16 patients with panniculitis were positive for antibodies to nuclear matrix protein 2 (anti-NXP2 antibodies). Conclusion: The data showed that panniculitis is an uncommon skin manifestation in adult patients with DM, with a positivity rate of 7.8%. The appearance of panniculitis is likely associated with anti-NXP2 antibodies.
{"title":"Panniculitis, an Uncommon Skin Manifestation in Adult Dermatomyositis","authors":"Xiaojing Xing, Song Wang, Anqi Li, Zihang Li, Biwen Lin","doi":"10.1097/JD9.0000000000000260","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000260","url":null,"abstract":"Objective: The skin manifestations of dermatomyositis (DM) are complex and diverse, with some rashes having diagnostic significance, while others have a certain suggestive effect on the patient’s condition, visceral damage, and prognosis. This case-cohort study was performed to investigate the skin manifestations of 205 adult inpatients with DM. We then analyzed the association between the clinical characteristics and panniculitis in adult patients with DM. Methods: This study was conducted at the First Medical Center of PLA General Hospital, Beijing, China from March 1, 2016 to December 30, 2020 with follow-up until December 31, 2021. This case-cohort study involved 205 eligible participants with DM who met the criteria for idiopathic inflammatory myopathy. Clinical data, cutaneous manifestations, and lesion locations were screened and analyzed. Serum samples were collected, and immunoblotting was used to detect 16 types of myositis-specific antibodies and myositis-associated antibodies. Results: The results showed that 16 (7.8%) of the 205 adult patients with DM had panniculitis. The panniculitis was mainly distributed in the subcutaneous fat of the abdomen, buttocks, and thighs. This condition was often accompanied by skin ulcers, atrophic scars, and calcinosis. Moreover, 9 (72.7%) of the 16 patients with panniculitis were positive for antibodies to nuclear matrix protein 2 (anti-NXP2 antibodies). Conclusion: The data showed that panniculitis is an uncommon skin manifestation in adult patients with DM, with a positivity rate of 7.8%. The appearance of panniculitis is likely associated with anti-NXP2 antibodies.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"6 1","pages":"96 - 101"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47524846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-11DOI: 10.1097/JD9.0000000000000259
B. Giomi, C. Silvestri, S. Bravi, C. Stasi, Lisa Bertini, Leslie Mechi, Serena Mordini, Nicoletta Zocco, F. Voller, F. Cipriani
Objective: Street-based female sex workers are more likely to practice unprotected sex with multiple partners increases their risk of infection with sexually transmitted diseases. This study was performed to evaluate the understanding of and risk factors for sexually transmitted diseases among street-based female sex workers. Methods: A survey consisted of a sociodemographic section and a health section was conducted from June to August in two consecutive years (2012-2013) using an anonymous questionnaire compiled by street-based female sex workers in the area of Florence (Central Italy). A descriptive analysis of sociodemographic, epidemiological, and anamnestic variables was performed using common methods for proportions; associations between variables were assessed using univariate and bivariate logistic regression. Results: Totally 122 street-based female sex workers (mean age, 24.1 years; age range, 17–45 years) were enrolled, and were from Europe (63.1%) (mainly from Romania [48.4%] and Albania [13.1%]), Africa (31.2%) (specifically Nigeria), and South America (5.7%). Of the 122 street-based female sex workers, 63% were married/engaged and 37% were single. More than half had been living in Italy and Florence for more than 1 year; 72.8% stated that they possessed a residence permit and the others were illegal migrants. Eighteen (15%) street-based female sex workers also worked in the industry in neighboring European countries. Their level of education was generally high: 58.1% had completed secondary school (lower secondary school and upper secondary school). A total of 81.4% stated that they perceived an actual fear of contracting human immunodeficiency virus; in fact, 43.3% had never been tested for any sexually transmitted diseases except for human immunodeficiency virus. Conclusion: Despite the long-time involvement of street-based female sex workers in the commercial sex industry, the large numbers of clients and a strong perception of concerns about sexually transmitted diseases. This study confirms a low rate of condom use and blood screening, and corresponding science education and health screening efforts need to be strengthened in this high risk population.
{"title":"Sexual Behavior and Awareness of Sexually Transmitted Diseases Among Street-Based Female Sex Workers in the Florence Area, Central Italy","authors":"B. Giomi, C. Silvestri, S. Bravi, C. Stasi, Lisa Bertini, Leslie Mechi, Serena Mordini, Nicoletta Zocco, F. Voller, F. Cipriani","doi":"10.1097/JD9.0000000000000259","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000259","url":null,"abstract":"Objective: Street-based female sex workers are more likely to practice unprotected sex with multiple partners increases their risk of infection with sexually transmitted diseases. This study was performed to evaluate the understanding of and risk factors for sexually transmitted diseases among street-based female sex workers. Methods: A survey consisted of a sociodemographic section and a health section was conducted from June to August in two consecutive years (2012-2013) using an anonymous questionnaire compiled by street-based female sex workers in the area of Florence (Central Italy). A descriptive analysis of sociodemographic, epidemiological, and anamnestic variables was performed using common methods for proportions; associations between variables were assessed using univariate and bivariate logistic regression. Results: Totally 122 street-based female sex workers (mean age, 24.1 years; age range, 17–45 years) were enrolled, and were from Europe (63.1%) (mainly from Romania [48.4%] and Albania [13.1%]), Africa (31.2%) (specifically Nigeria), and South America (5.7%). Of the 122 street-based female sex workers, 63% were married/engaged and 37% were single. More than half had been living in Italy and Florence for more than 1 year; 72.8% stated that they possessed a residence permit and the others were illegal migrants. Eighteen (15%) street-based female sex workers also worked in the industry in neighboring European countries. Their level of education was generally high: 58.1% had completed secondary school (lower secondary school and upper secondary school). A total of 81.4% stated that they perceived an actual fear of contracting human immunodeficiency virus; in fact, 43.3% had never been tested for any sexually transmitted diseases except for human immunodeficiency virus. Conclusion: Despite the long-time involvement of street-based female sex workers in the commercial sex industry, the large numbers of clients and a strong perception of concerns about sexually transmitted diseases. This study confirms a low rate of condom use and blood screening, and corresponding science education and health screening efforts need to be strengthened in this high risk population.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"5 1","pages":"226 - 230"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46800410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-11DOI: 10.1097/JD9.0000000000000264
Yan Zhao, Li-ming Wu, Q. Lu, Xing-Hua Gao, Xiaolin Zhu, X. Yao, Linfeng Li, Wei Li, Yangfeng Ding, Zhi-qiang Song, Ling-ling Liu, N. Dang, Chunfeng Zhang, Xiao-Ming Liu, J. Gu, Jin-Yan Wang, S. Geng, Quanzhong Liu, Yifeng Guo, Li-Li Dong, Shell Li, Christine R. Xu, J. O’Malley, E. Laws, N. Amin, A. Bansal, Min Wang, Jian-Zhong Zhang
Objective: Limited information is available on the use of dupilumab for the treatment of atopic dermatitis (AD) in the Chinese population. Methods: We analyzed laboratory data from a previously published randomized, double-blind phase III trial (NCT03912259) to provide further insight into the safety of dupilumab in Chinese adults with moderate to severe AD. The trial participants received either 300 mg of dupilumab or placebo every 2 weeks for 16 weeks. Hematology, blood chemistry, serum thymus and activation-regulated chemokine (TARC), and total immunoglobulin E (IgE) were evaluated. Results: In total, 82 participants received dupilumab and 83 received placebo. With the exception of eosinophil counts of >0.8 × 109/L, which were found less frequently with dupilumab (9.8%) than with placebo (18.7%), the hematology and blood chemistry values were generally stable in both treatment groups. There were no clinically significant differences between the dupilumab and placebo groups, and no participants developed treatment-emergent abnormalities of potential clinical significance. However, compared with placebo, greater decreases in serum lactate dehydrogenase (mean change, −97.4 vs. −33.5 IU/L), TARC (median percent change, −78.6% vs. −30.8%), and total IgE (median percent change, −53.4% vs. −0.2%) were observed with dupilumab than placebo at week 16. Conclusion: Dupilumab demonstrated a favorable laboratory safety profile in Chinese adults with moderate to severe AD.
{"title":"Laboratory Safety of Dupilumab, and Its Effect on Inflammatory Biomarkers, in Chinese Adults With Moderate-to-Severe Atopic Dermatitis: An Analysis of a Randomized, Double-Blind Phase III Study","authors":"Yan Zhao, Li-ming Wu, Q. Lu, Xing-Hua Gao, Xiaolin Zhu, X. Yao, Linfeng Li, Wei Li, Yangfeng Ding, Zhi-qiang Song, Ling-ling Liu, N. Dang, Chunfeng Zhang, Xiao-Ming Liu, J. Gu, Jin-Yan Wang, S. Geng, Quanzhong Liu, Yifeng Guo, Li-Li Dong, Shell Li, Christine R. Xu, J. O’Malley, E. Laws, N. Amin, A. Bansal, Min Wang, Jian-Zhong Zhang","doi":"10.1097/JD9.0000000000000264","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000264","url":null,"abstract":"Objective: Limited information is available on the use of dupilumab for the treatment of atopic dermatitis (AD) in the Chinese population. Methods: We analyzed laboratory data from a previously published randomized, double-blind phase III trial (NCT03912259) to provide further insight into the safety of dupilumab in Chinese adults with moderate to severe AD. The trial participants received either 300 mg of dupilumab or placebo every 2 weeks for 16 weeks. Hematology, blood chemistry, serum thymus and activation-regulated chemokine (TARC), and total immunoglobulin E (IgE) were evaluated. Results: In total, 82 participants received dupilumab and 83 received placebo. With the exception of eosinophil counts of >0.8 × 109/L, which were found less frequently with dupilumab (9.8%) than with placebo (18.7%), the hematology and blood chemistry values were generally stable in both treatment groups. There were no clinically significant differences between the dupilumab and placebo groups, and no participants developed treatment-emergent abnormalities of potential clinical significance. However, compared with placebo, greater decreases in serum lactate dehydrogenase (mean change, −97.4 vs. −33.5 IU/L), TARC (median percent change, −78.6% vs. −30.8%), and total IgE (median percent change, −53.4% vs. −0.2%) were observed with dupilumab than placebo at week 16. Conclusion: Dupilumab demonstrated a favorable laboratory safety profile in Chinese adults with moderate to severe AD.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"5 1","pages":"218 - 225"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41479720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-11DOI: 10.1097/jd9.0000000000000262
Yi-Ping Ma, H. Jia
{"title":"Secukinumab efficacy in the treatment of pediatricpsoriasis in China: a case series","authors":"Yi-Ping Ma, H. Jia","doi":"10.1097/jd9.0000000000000262","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000262","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47345145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-11DOI: 10.1097/jd9.0000000000000265
Hira Tariq, Shahbano Jawad, S. Aman, Anjum Saeed, H. Cheema
{"title":"Lipoid Proteinosis Due to Homozygous Nonsense Mutation in Extracellular Matrix Protein 1 (ECM1) Gene in Three Pakistani Siblings","authors":"Hira Tariq, Shahbano Jawad, S. Aman, Anjum Saeed, H. Cheema","doi":"10.1097/jd9.0000000000000265","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000265","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46086166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of Basal Cell Carcinoma Involving the Medial Canthus by Multiple Local Flaps: A Case Report","authors":"Yang-Honghong Fei, Jian Jin, Hua-Feng Sun, H. Fan, X. Hong, Ai-fen Chen, Hai-shan Lu, Jin-fang Wu","doi":"10.1097/jd9.0000000000000266","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000266","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42206146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-11DOI: 10.1097/jd9.0000000000000263
Lihong Chen, Jie Zheng, Xia Li
{"title":"Anemia and thrombocytosis associated with erythrodermic psoriasis successfully treated with ixekizumab: A case report","authors":"Lihong Chen, Jie Zheng, Xia Li","doi":"10.1097/jd9.0000000000000263","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000263","url":null,"abstract":"","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45835583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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