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Omnidirectional tele-perception enabled by nano-architectured electret skin 纳米结构驻极体皮肤实现全方位远程感知

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-31 DOI: 10.1016/j.isci.2025.114584

Yan Du , Zhiwei Zhang , Zhong Lin Wang , Di Wei

The environmental perception capability of embodied intelligent systems is highly dependent on their physical interactions with the surrounding environment, where tele-perception serves as a key technology enabling adaptive interaction and real-time human-machine interaction (HMI). However, existing tele-perception systems are fundamentally constrained by their underlying physical mechanisms and environmental disturbances, resulting in limited sensing directionality, poor spatial resolution, and inadequate environmental robustness. To address these challenges, this study develops an omnidirectional nano-architectured electret skin (NAES) by precisely tuning charge-trapping units within the established heterogeneous interface of the charge transport layer (CTL) and charge blocking layer (CBL). The proposed architecture arranges NAES units along 0°, 45°, 90°, 135°, and four diagonal orientations, leveraging the anisotropic electrostatic disturbance responses of each unit to achieve high-precision tele-perception of omnidirectional targets in three-dimensional space. This design overcomes the unidirectional sensing limitation of conventional NAES systems, enabling enhanced spatial perception and adaptive omnidirectional interaction in complex, dynamic environments.

嵌入式智能系统的环境感知能力高度依赖于其与周围环境的物理交互，其中远程感知是实现自适应交互和实时人机交互（HMI）的关键技术。然而，现有的远程感知系统从根本上受到其潜在物理机制和环境干扰的限制，导致传感方向性有限，空间分辨率差，环境鲁棒性不足。为了解决这些挑战，本研究通过在电荷传输层（CTL）和电荷阻断层（CBL）的非均质界面内精确调整电荷捕获单元，开发了一种全向纳米结构驻极体皮肤（NAES）。该架构将NAES单元沿0°、45°、90°、135°和四个对角线方向排列，利用各单元的各向异性静电扰动响应，实现三维空间中全向目标的高精度遥测。该设计克服了传统NAES系统单向感知的限制，在复杂、动态的环境中增强了空间感知和自适应全方位交互。

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引用次数: 0

Catching common carp with eDNA in Thailand’s rivers 用eDNA在泰国的河流中捕捉普通鲤鱼

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-31 DOI: 10.1016/j.isci.2025.114583

Maslin Osathanunkul , Sarawut Ounjai , Rossarin Osathanunkul , Panagiotis Madesis

Common carp (Cyprinus carpio) are both ecologically disruptive invaders and economically important aquaculture species in Thailand. This study applied environmental DNA (eDNA) analysis with digital PCR (dPCR) and Bayesian occupancy modeling to assess carp distribution across five major river systems from 2022 to 2024. eDNA was detected at 80% of surveyed sites in 2022, increasing to 96% by 2024, with higher concentrations particularly in the Nan and Ping rivers. Occupancy probabilities remained relatively stable across years, while rising eDNA concentrations indicate greater detectability and possible local increases in biomass. Detection probabilities were high at both field and laboratory stages, confirming methodological reliability. While aquaculture escapes and hydrological drivers are plausible influences, these factors were not directly tested. The findings provide robust baseline evidence of widespread persistence of common carp in Thailand’s rivers and highlight the potential of eDNA as a scalable, cost-effective tool for freshwater monitoring and management.

鲤鱼（Cyprinus carpio）是一种具有生态破坏性的外来入侵物种，也是泰国重要的水产养殖物种。本研究应用环境DNA （eDNA）分析、数字PCR （dPCR）和贝叶斯占用模型对2022 - 2024年五大河流水系的鲤鱼分布进行了评估。2022年，80%的调查地点检测到eDNA，到2024年增加到96%，特别是在南河和平河的浓度较高。多年来，占据概率保持相对稳定，而eDNA浓度的上升表明可探测性更强，生物量可能在局部增加。在现场和实验室阶段的检测概率都很高，证实了方法的可靠性。虽然水产养殖逃逸和水文驱动因素是可能的影响因素，但这些因素没有得到直接测试。这些发现为泰国河流中鲤鱼的广泛持久性提供了强有力的基线证据，并突出了eDNA作为可扩展的、具有成本效益的淡水监测和管理工具的潜力。

引用次数: 0

Microplastic contamination in the pristine waters of Tilicho Lake, Nepal: A groundbreaking study in the high-altitude himalayas 尼泊尔提利哥湖原始水域的微塑料污染：一项在高海拔喜马拉雅山的开创性研究

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-31 DOI: 10.1016/j.isci.2025.114595

Sahil Shrestha , Ajaya Subedi , Michael J. Angove , Kedar Rijal , Pramod Poudel , Shukra Raj Paudel

Microplastics (MPs) are studied extensively in various environments worldwide; however, their presence in remote, high-altitude freshwater lakes remains underreported. These alpine lakes serve as both upstream water sources and sinks for MPs, highlighting the urgent need for scientific investigation. In this study, we present the first assessment of MP contamination in Tilicho Lake—located at an elevation of 4,917 m.a.s.l., among the world’s highest lakes and a popular destination for Himalayan trekkers. Surface water samples from six different nearshore locations revealed an average MP concentration of 42 ± 18 particles per liter. Spatial variability in MP levels showed a strong correlation with the level of tourist accessibility, indicating that tourism and associated plastic waste are significant sources of MP contamination. This growing MP pollution, intensified by increasing tourism and climate change, highlights the pressing need for strengthened policies and environmentally sustainable practices to protect these ecologically sensitive alpine environments.

微塑料（MPs）在世界各地的各种环境中被广泛研究；然而，它们在偏远的高海拔淡水湖中的存在仍然被低估。这些高山湖泊既是上游的水源，也是MPs的汇，这凸显了科学调查的迫切需要。在这项研究中，我们提出了第一个对Tilicho湖的MP污染的评估，该湖位于海拔4917米的地方，是世界上最高的湖泊之一，也是喜马拉雅徒步旅行者的热门目的地。来自六个不同近岸地点的地表水样本显示，每升平均MP浓度为42±18个颗粒。MP水平的空间变异性与旅游可达性水平有很强的相关性，表明旅游业和相关的塑料废物是MP污染的重要来源。随着旅游业的发展和气候变化的加剧，日益严重的山地污染凸显了加强政策和环境可持续做法的迫切需要，以保护这些生态敏感的高山环境。

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引用次数: 0

Study on sodium ion supplementation performance of CNT-coated sodium oxalate in sodium ion batteries 碳纳米管包覆草酸钠在钠离子电池中的钠离子补充性能研究

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-31 DOI: 10.1016/j.isci.2025.114581

Shengdong Tao , Yanyan Xuan , Jian Li , Kewei Lei , Zulv Huang , Guowen He , Kun Shen , Zheng Liu , Zhifang Yin

Low initial coulombic efficiency of hard carbon anodes and irreversible sodium loss during cycling in sodium-ion batteries (SIBs) lead to reduced specific capacity and shortened cycle life. Introducing sodium supplementation can effectively enhance the specific capacity and cycle life of SIBs. Na₂C₂O₄ was selected as the sodium compensation agent owing to its high theoretical capacity, excellent chemical stability, and environmental friendliness. To improve conductivity and reduce decomposition voltage of Na₂C₂O₄, carbon nanotubes (CNTs) were employed for coating. The optimized 10% CNT-coated sodium oxalate (CNT-10@Na₂C₂O₄) exhibited a reduced initial decomposition voltage of 3.82 V (vs. Na⁺/Na) and delivered an irreversible (sodium compensation) capacity of 392.65 mAh g⁻¹. NNFMO-CN||HC full cells were assembled using NaNi_1/3Fe_1/3Mn_1/3O₂ cathode containing 10% CNT-10@Na₂C₂O₄ and hard carbon anode, demonstrating a discharge retention capacity of 38.35 mAh g⁻¹ after 100 cycles, higher than the retained capacity of only 15.16 mAh g⁻¹ of the NNFMO||Na cell without CNT-10@Na₂C₂O₄. These results indicate that CNT-10@Na₂C₂O₄ significantly improves the specific capacity and cycling performance of SIBs.

钠离子电池中硬碳阳极初始库仑效率低，循环过程中不可逆的钠损失导致比容量降低，循环寿命缩短。添加钠能有效提高SIBs的比容量和循环寿命。Na2C2O4具有理论容量高、化学稳定性好、环境友好等优点，被选为钠补偿剂。为了提高Na2C2O4的电导率和降低分解电压，采用碳纳米管（CNTs）进行涂层处理。优化后的10%碳纳米管包被草酸钠（CNT-10@Na2C2O4）的初始分解电压降低了3.82 V (vs. Na+/Na)，并且提供了392.65 mAh g−1的不可逆（钠补偿）容量。使用含有10% CNT-10@Na2C2O4的NaNi1/3Fe1/3Mn1/3O2阴极和硬碳阳极组装NNFMO- cn ||全HC电池，在100次循环后的放电保持容量为38.35 mAh g−1，高于不含CNT-10@Na2C2O4的NNFMO||Na电池的15.16 mAh g−1。结果表明，CNT-10@Na2C2O4显著提高了sib的比容量和循环性能。

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引用次数: 0

Targeting Piezo1 can improve endometrial fibrosis by inhibiting ferroptosis in endothelial cells 靶向Piezo1可通过抑制内皮细胞铁下垂改善子宫内膜纤维化

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-31 DOI: 10.1016/j.isci.2025.114540

Huan Yang , Chaoxun Dou , Ruohong Pan , Yaoyao Xu , Kaixuan Zeng , Jiayu Huang , Lu Sun , Yuqing Yao , Jiancheng Wang

Intrauterine adhesion (IUA) is a fibrotic disorder characterized by excessive extracellular matrix deposition, leading to menstrual abnormalities, infertility, and recurrent miscarriage, for which effective treatments are lacking. Here, we employed single-cell RNA sequencing to analyze murine IUA models, revealing for the first time a significant reduction in endometrial endothelial cells accompanied by markedly upregulated Piezo1 expression. Functional enrichment analysis demonstrated ferroptosis as the most prominently activated cell death pathway in IUA endometrial endothelial cells versus controls. Mechanistically, elevated matrix stiffness activates Piezo1 in endometrial endothelial cells, inducing iron overload, lipid peroxidation, and mitochondrial dysfunction, culminating in ferroptosis. Intrauterine administration of the Piezo1 inhibitor GsMTx4 attenuated stiffness-induced ferroptosis and significantly reduced endometrial fibrosis in murine IUA models. Collectively, matrix stiffness represents a therapeutic target for IUA, and targeting mechanotransduction pathways effectively counteracts endothelial ferroptosis to ameliorate endometrial fibrosis.

宫内粘连（IUA）是一种以细胞外基质过度沉积为特征的纤维化疾病，可导致月经异常、不孕症和反复流产，目前缺乏有效的治疗方法。在这里，我们使用单细胞RNA测序来分析小鼠IUA模型，首次揭示子宫内膜内皮细胞的显著减少伴随着Piezo1表达的显著上调。功能富集分析表明，与对照组相比，IUA子宫内膜内皮细胞中，铁下垂是最显著的激活细胞死亡途径。从机制上说，升高的基质刚度激活了子宫内膜内皮细胞中的Piezo1，诱导铁超载、脂质过氧化和线粒体功能障碍，最终导致铁垂亡。在小鼠IUA模型中，子宫内给予Piezo1抑制剂GsMTx4可减轻刚性诱导的铁上吊，并显著减少子宫内膜纤维化。总的来说，基质硬度代表了IUA的治疗靶点，靶向机械转导途径有效地抵消内皮铁下垂以改善子宫内膜纤维化。

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引用次数: 0

The role of arachidonic acid metabolites in the subtype classification and pathogenesis of primary aldosteronism 花生四烯酸代谢物在原发性醛固酮增多症亚型、分类和发病机制中的作用

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-31 DOI: 10.1016/j.isci.2025.114598

Mei You , Li Li , Xintao Tan , Xiaoli Liu , Lijuan Wang , Tingbing Cao , Bowen Wang , Min Liu , Yue Gao , Qing Zhou , Ruomei Yang , Weihua Lan , Peng Gao , Zhiming Zhu , Zhencheng Yan

Primary aldosteronism (PA) is a common form of secondary hypertension with a complex diagnostic process and incompletely understood pathogenesis. In this controlled cross-sectional study, metabolomic profiling of 37 patients with bilateral PA, 38 with unilateral PA, and 20 with essential hypertension (EH) revealed that the most prominent metabolic difference lies in lipid metabolism, particularly arachidonic acid (AA) metabolism. We identified a panel of AA metabolites that improved PA subtyping. Additionally, levels of most AA metabolites were markedly reduced in PA patients after curative adrenal ablation. Mechanistically, treatment with AA enhanced the uptake of calcium ions and stimulated the proliferation and migration of adrenal cortical cells, with increased expressions of aldosterone synthase CYP11B2 and the calcium ion channel transient receptor potential canonical 3 (TRPC3). Furthermore, an inhibitor of TRPC3, pyr3, blocked these effects of AA. These findings elucidate the role of AA metabolites in PA pathogenesis and highlight them as potential targets for therapeutic intervention.

原发性醛固酮增多症（PA）是一种常见的继发性高血压，诊断过程复杂，发病机制尚不完全清楚。在这项对照横断面研究中，对37例双侧PA患者、38例单侧PA患者和20例原发性高血压（EH）患者的代谢组学分析显示，最显著的代谢差异在于脂质代谢，尤其是花生四烯酸（AA）代谢。我们发现一组AA代谢物可以改善PA亚型。此外，在治疗性肾上腺消融后，PA患者的大多数AA代谢物水平显著降低。机制上，AA增强钙离子的摄取，刺激肾上腺皮质细胞的增殖和迁移，醛固酮合成酶CYP11B2和钙离子通道瞬时受体电位规范3 （TRPC3）的表达增加。此外，TRPC3的抑制剂pyr3阻断了AA的这些作用。这些发现阐明了AA代谢物在PA发病机制中的作用，并强调它们是治疗干预的潜在靶点。

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引用次数: 0

Switchable electrosynthesis of C-1-unsubstituted imidazopyridines c -1-未取代咪唑吡啶的可切换电合成

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-30 DOI: 10.1016/j.isci.2025.114588

Jinlin Hang , Meng Chen , Weibin Ma , Zefu Zheng , Zheng Fang , Ning Zhu , Chengkou Liu

Oxidative coupling and cyclocondensation reactions to produce imidazopyridine have been attractive methodologies because of their inherent atom- and step-economy, which have been well established using exogenous oxidants, especially I₂. However, the straightforward and efficient preparation of C-1-unsubstituted-imidazopyridine remains an unsolved challenge, because the core features of imidazopyridine are low oxidation potential and can be easily oxidized to give the C-1-substituted byproduct. Herein, we developed a highly efficient and clean electrosynthesis of C-1-unsubstituted imidazo[1,5-a]pyridine using a user-friendly undivided cell under exogenous oxidant- and transition metal-free conditions. Moreover, the switchable access to imidazo[1,5-a]pyridine was achieved from the oxidative cyclization of two equivalents of pyridin-2-ylmethylamine or the oxidative cyclocondensation of pyridin-2-ylmethylamine and aryl methyl ketones.

氧化偶联和环缩合反应制备咪唑吡啶的方法因其固有的原子经济性和阶梯经济性而备受关注，这些方法已经在使用外源氧化剂，特别是I2的情况下得到了很好的证实。然而，直接高效地制备c -1-未取代咪唑吡啶仍然是一个未解决的挑战，因为咪唑吡啶的核心特征是低氧化电位，很容易氧化得到c -1取代的副产物。在此，我们开发了一种高效、清洁的电合成c -1-未取代咪唑[1,5-a]吡啶的方法，使用用户友好的未分裂电池，在外源无氧化剂和无过渡金属的条件下。此外，咪唑[1,5-a]吡啶可通过两种吡啶-2-基甲胺的氧化环化反应或吡啶-2-基甲胺和芳基甲基酮的氧化环缩合反应获得。

引用次数: 0

Fission yeast Whi5 represses MBF-dependent transcription in quiescent cells 裂变酵母wh5在静止细胞中抑制mbf依赖性转录

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-30 DOI: 10.1016/j.isci.2025.114576

Celia Gálvez-Merchán , Rafael López-San Segundo , M. Belén Suárez , Daniel González-Álvarez , José Ayté , Livia Pérez-Hidalgo , Sergio Moreno

When cells arrest in G1 to enter quiescence, the transcriptional machinery that drives the G1/S transition must be inactivated. In budding yeast and mammals, this repression is mediated by the Whi5 and Retinoblastoma (Rb) proteins, which inhibit the SBF and E2F transcription factors, respectively. In fission yeast, the MBF complex is functionally analogous to SBF and E2F, and Whi5/Mug54 has been predicted to act as a G1/S transcriptional repressor. Here, we show that upon nitrogen starvation, Whi5 accumulates in the nucleus and is required to repress MBF-dependent genes during quiescence. Mass spectrometry and bimolecular fluorescence complementation (BiFC) demonstrate that Whi5 physically associates with components of both the MBF complex and the histone deacetylase Clr6-I complex. Moreover, Whi5 is required for the interaction between MBF and Clr6-I, supporting a model in which Whi5 represses MBF-dependent genes in quiescent cells by recruiting HDAC activity to their promoters.

当细胞在G1期停止进入静止状态时，驱动G1/S转变的转录机制必须失活。在出芽酵母和哺乳动物中，这种抑制是由wh5和视网膜母细胞瘤（Rb）蛋白介导的，它们分别抑制SBF和E2F转录因子。在裂变酵母中，MBF复合物的功能类似于SBF和E2F，并且wh5 /Mug54被预测为G1/S转录抑制因子。在这里，我们发现在氮饥饿时，wh5在细胞核中积累，并且在静止期间需要抑制mbf依赖基因。质谱和双分子荧光互补（BiFC）表明，wh5与MBF复合物和组蛋白去乙酰化酶Clr6-I复合物的组分都有物理关联。此外，wh5是MBF和Clr6-I之间相互作用所必需的，这支持了wh5通过将HDAC活性募集到启动子中来抑制静止细胞中MBF依赖基因的模型。

引用次数: 0

Circadian ADCY3 Ser107Pro variant bridges difficulty awakening in the morning and adiposity 昼夜ADCY3 Ser107Pro变异连接了早晨难以醒来和肥胖

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-30 DOI: 10.1016/j.isci.2025.114587

Cynthia Tchio , Matthew Maher , Christopher Moth , Jens Meiler , Jacqueline M. Lane , Herman A. Taylor , Jonathan S. Williams , Richa Saxena

Modern lifestyles often disturb circadian rhythms, yet the genetic circuits that convert this stress into metabolic dysfunction remain poorly defined. Here, we identify a missense variant in ADCY3 (rs11676272; Ser107Pro) as a pleiotropic regulator of circadian preference and adiposity. Using genome-wide pleiotropy analysis in ∼480,000 UK Biobank participants, we show that the G risk allele (Pro107) increases eveningness, BMI, and fat mass in European (n = 451,324) and African (n = 8,738) ancestry groups, with behavioral amplification by morning difficulty awakening in Europeans and power-limited modeling in other populations. Structural modeling and transcriptomic analysis suggest this allele alters adipose-specific splicing and expression and destabilizes ADCY3 protein. In mice, Adcy3 is rhythmically expressed in adipose tissue, with BMAL1 binding near the orthologous residue 107 site. Human adipose ADCY3 expression also increases after weight loss. Together, these findings reveal a genotype-dependent, behaviorally modifiable axis connecting difficulty awakening to metabolic risk through circadian and adipose regulatory pathways.

现代生活方式经常扰乱昼夜节律，但将这种压力转化为代谢功能障碍的基因回路仍不明确。在这里，我们发现ADCY3的一个错义变体（rs11676272; Ser107Pro）是昼夜节律偏好和肥胖的多效调节因子。通过对48万名英国生物银行参与者的全基因组多效性分析，研究人员发现，G风险等位基因（Pro107）在欧洲（n = 451,324）和非洲（n = 8,738）祖先群体中增加了夜间性、BMI和脂肪量，在欧洲人中出现了早晨难以醒来的行为放大，在其他人群中出现了能量受限模型。结构建模和转录组学分析表明，该等位基因改变了脂肪特异性剪接和表达，并使ADCY3蛋白不稳定。在小鼠中，Adcy3在脂肪组织中有节律地表达，BMAL1在同源残基107位点附近结合。人脂肪ADCY3的表达也在减肥后增加。总之，这些发现揭示了一个基因型依赖的、行为可改变的轴，通过昼夜节律和脂肪调节途径将唤醒困难与代谢风险联系起来。

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引用次数: 0

Small proteins from prokaryotes in the marine water column at full ocean depth 原核生物的小蛋白质在海洋深处的海水中

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience

Pub Date : 2025-12-30 DOI: 10.1016/j.isci.2025.114585

Qing-Mei Li , Li-Sheng He , Yong Wang

Small proteins (SPs, ≤50 aa) are often overlooked in genomics. We conducted the first systematic analysis of prokaryotic SPs across the full ocean-depth gradient. From 433,311 short open reading frames (sORFs) predicted from 71 western Pacific metagenomes, we identified 193,281 SP clusters. Filtration yielded 75,581 prevalent SPs, including 4,307 high-confidence clusters (RfSPs). Notably, 87.09% of RfSPs lacked non-marine homologs, and ∼70% contained unknown domains. While most (65.57%) were phylum-specific, twelve were distributed across ≥5 phyla, and some were prophage-associated. Geographically, twenty-three core RfSPs were universally present. Co-occurrence analysis revealed that interacting RfSPs typically originated from the same or adjacent zones. Finally, we confirmed the transcription of 8.20% RfSP clusters in deep-sea metatranscriptomes. The zone-specific transcription of certain RfSPs suggests adaptive functions, such as stress response and molecular chaperoning, in distinct marine environments. Our study reveals SPs as a critical strategy for prokaryotic adaptation to deep-sea stressors.

小蛋白（SPs,≤50 aa）在基因组学中经常被忽视。我们首次对整个海洋深度梯度的原核SPs进行了系统分析。从71个西太平洋宏基因组预测的433311个短开放阅读帧（sorf）中，我们确定了193281个SP集群。过滤得到75,581个流行SPs，包括4,307个高置信度集群（RfSPs）。值得注意的是，87.09%的RfSPs缺乏非海洋同源物，约70%含有未知结构域。大多数（65.57%）是门特异性的，12个分布在≥5门，一些是与噬菌体相关的。从地理上看，23个核心rfsp普遍存在。共现分析表明，相互作用的rfsp通常来自相同或相邻区域。最后，我们确认了8.20%的RfSP簇在深海亚转录组中的转录。某些RfSPs的区域特异性转录表明在不同的海洋环境中具有适应性功能，如应激反应和分子陪伴。我们的研究揭示了SPs是原核生物适应深海应激源的关键策略。

引用次数: 0

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