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Prolonged type 1 diabetes honeymoon period: Case report and review of the literature 延长1型糖尿病蜜月期:病例报告及文献回顾
Pub Date : 2020-07-01 DOI: 10.4103/KKUJHS.KKUJHS_23_20
Moeber M. Mahzari
The clinical and biochemical variables of a patient with unusual and relatively long? type 1 diabetes (T1DM) remission are reported. The case is followed by literature review of interventions with a positive impact on T1DM remission. The patient has clinical and biochemical phenotype consistent with T1DM. He refused to take treatment for diabetes. He has been using Trigonella foenum-graecum as the only treatment for diabetes. The patient has not developed diabetic ketoacidosis until the time of this report (34 months after his initial diagnosis), which is unusual for patients with T1DM. The positive effect of Trigonella foenum-graecum on T1DM remission in this patient is not ascertained but possible. Relevant literature of studies and case reports of similar prolonged T1DM remission reviewed and summarized. There is a clear need to continue exploring interventions in prospective studies to induce and prolong T1DM remission.
患者的临床生化指标异常且相对较长?1型糖尿病(T1DM)缓解的报道。病例之后是文献综述干预措施对T1DM缓解的积极影响。患者临床及生化表型符合T1DM。他拒绝接受糖尿病治疗。他一直把葫芦巴菌作为治疗糖尿病的唯一药物。患者在初次诊断34个月后才出现糖尿病酮症酸中毒,这在T1DM患者中并不常见。凹谷trigonella veenum -graecum对该患者T1DM缓解的积极作用尚未确定,但可能。回顾并总结了类似延长T1DM缓解期的相关研究文献和病例报告。显然,有必要在前瞻性研究中继续探索干预措施,以诱导和延长T1DM缓解。
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引用次数: 0
Eosinophilic gastroenteritis presenting as persistent abdominal pain and ascites: A case report 嗜酸性胃肠炎表现为持续腹痛和腹水:1例报告
Pub Date : 2020-07-01 DOI: 10.4103/KKUJHS.KKUJHS_3_20
M. Alzahrani
Eosinophilic gastroenteritis (EGE) is a rare benign inflammatory disease affecting the infant and adult population. It presents by eosinophilic infiltration of the intestinal tract wall including the stomach, small intestines, and rarely the colon. EGE is divided into three subtypes depending on the layers and extent of bowel involved (mucosal, muscular, and serosal). Accurate diagnosis is still considered a challenge to professionals because of the protean manifestations; it needs a combination of clinical, laboratory, radiological, and histological workup. We report here a case of a 35-year-old male with a 3-month history of abdominal pain and distension. On examination, we found mild-to-moderate ascites and peripheral eosinophilia with markedly elevated eosinophils (85%). The imaging studies showed bowel wall thickening involving the entire small bowel and mild duodenitis. The diagnosis was confirmed by duodenal biopsy. The patient was managed with steroids (prednisolone 40 mg) and had an excellent response to the treatment. There is no single laboratory test or procedure to diagnose EGE; it requires a combination of laboratory, radiologic, and endoscopic findings. This report will guide decision-making for the initial phase of treatment and maintenance therapy in a more consistent way.
嗜酸性胃肠炎(EGE)是一种罕见的影响婴儿和成人的良性炎症性疾病。表现为嗜酸性粒细胞浸润肠壁,包括胃、小肠,很少出现结肠。根据肠的层数和受累程度(粘膜、肌肉和浆膜),EGE可分为三种亚型。由于表现多变,准确的诊断仍然被认为是对专业人员的挑战;它需要临床、实验室、放射学和组织学检查的结合。我们在此报告一例35岁男性,腹痛和腹胀3个月的病史。在检查中,我们发现轻度至中度腹水和外周嗜酸性粒细胞明显升高(85%)。影像学检查显示肠壁增厚累及整个小肠和轻度十二指肠炎。诊断经十二指肠活检证实。患者接受类固醇治疗(强的松龙40mg),治疗效果良好。没有单一的实验室测试或程序来诊断EGE;它需要结合实验室、放射学和内窥镜检查结果。该报告将以更一致的方式指导初始阶段治疗和维持治疗的决策。
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引用次数: 0
The clinical utility of red blood cells and reticulocyte-related indices for early detection of latent Iron deficiency 红细胞及网织红细胞相关指标在早期检测潜伏性缺铁中的临床应用
Pub Date : 2020-07-01 DOI: 10.4103/KKUJHS.KKUJHS_6_20
Husain Y. Alkhaldy
Background: Iron deficiency (ID) with and without anemia is common among young women of childbearing age. Screening and early diagnosis of ID before anemia develops are relevant to manage before the symptomatic stage. Several automated red blood cell (RBC) and reticulocyte indices have been investigated to identify early ID. Objectives: To explore the clinical utility of both old (MCV, MCH, and MCHC) and new (Ret-He and IFR) indices for detecting latent ID before the symptomatic anemia stage develops. Methods: A group of female college students at high altitude southern Saudi Arabia was assessed for iron status and associated anemia. Three groups were identified, ID anemia (IDA) group, ID without anemia (i.e., latent ID), and normal group. The lab generated RBC related indices (mean corpuscular volume [MCV], mean corpuscular hemoglobin [MCH], and mean corpuscular hemoglobin concentration), And reticulocyte count and their derived indices (reticulocyte hemoglobin content [RET-He] and immature reticulocyte fraction [IRF]) were collected. The RBC and Reticulocyte indices were compared between the normal, ID and IDA groups in order to identify possible distinguishing parameters of early ID state. Descriptive analysis and significance testing were performed. Results: Ninety-two of two hundred participants (46%) were found to have a latent ID and 30 (15%) had IDA. Hemoglobin, MCV, and MCH showed progressive decrement on their values from the iron replete through iron deplete state to full-blown anemia state. Reticulocytes count and MCV/MCH were significantly lower in the latent ID group compared to the normal group. RET-He and IRF showed no statistical difference between the latent ID and normal groups. Conclusion: Latent ID, before anemia develops, is associated with significant RBC indices, MCV/MCH, changes. These changes can be used to follow-up and detect early recurrence of ID. At our setting of high altitude, Ret-He shows no clinical utility in early diagnosis of ID state. Reticulocyte count drops early before qualitative reticulocyte indices like RET-He, a finding that could be attributed to baseline high-altitude-associated erythrocytosis.
背景:铁缺乏(ID)伴或不伴贫血在年轻育龄妇女中很常见。在贫血发生前的筛查和早期诊断与症状期前的治疗有关。几种自动红细胞(RBC)和网织红细胞指数已被研究用于识别早期ID。目的:探讨旧指标(MCV、MCH和MCHC)和新指标(Ret-He和IFR)在症状性贫血阶段发展前检测潜伏性ID的临床应用价值。方法:对沙特阿拉伯南部高海拔地区的一组女大学生进行铁含量和相关贫血的评估。分为三组,ID贫血(IDA)组、ID无贫血(即潜伏性ID)组和正常组。收集实验室生成的红细胞相关指标(平均红细胞体积[MCV]、平均红细胞血红蛋白[MCH]、平均红细胞血红蛋白浓度),网织红细胞计数及其衍生指标(网织红细胞血红蛋白含量[RET-He]、未成熟网织红细胞分数[IRF])。比较正常组、ID组和IDA组红细胞和网织红细胞指数,以确定早期ID状态的可能区分参数。进行描述性分析和显著性检验。结果:200名参与者中有92人(46%)被发现有潜在的ID, 30人(15%)有IDA。血红蛋白、MCV和MCH从缺铁→补铁→全面贫血状态呈进行性递减。与正常组相比,潜伏性ID组的网织红细胞计数和MCV/MCH显著降低。RET-He和IRF在潜伏性ID组与正常组之间无统计学差异。结论:贫血发生前的潜伏性ID与红细胞MCV/MCH变化相关。这些变化可用于随访和早期发现ID复发。在我们的高海拔环境下,Ret-He在早期诊断ID状态方面没有临床应用价值。网织红细胞计数早于定性网织红细胞指数(如RET-He)下降,这一发现可能归因于基线高海拔相关性红细胞增多。
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引用次数: 0
Knowledge, attitude, awareness, and motivation of blood donation among academic staff in health colleges in the southern region of Saudi Arabia 沙特阿拉伯南部地区卫生院校学术人员献血的知识、态度、意识和动机
Pub Date : 2018-07-01 DOI: 10.4103/1658-743x.291948
Hassan A. Hamali
Objectives: The current study aimed to investigate and evaluate the knowledge, attitude, awareness, and motivation about blood donation among academic staff in health colleges in Southern region of Saudi Arabia. Methods: A cross-sectional descriptive study was conducted in two universities in the Southern region of Saudi Arabia. The participants were the academic staff in health colleges at King Khalid University, Abha, and Jazan University, Jazan, during 2016. A validated, well-structured questionnaire was used to collectdata. Bivariate logistic regression analysis and odds ratio (OR) were used to assess the knowledge, attitude, awareness, and motivation about blood donation among the study participants. Results: The results showed vast knowledge about blood groups among academic staff, which was significantly associated with their educational level (OR, 4.161; 95% confidence interval [CI], 2.313— 7.484). Knowledge of the Rhesus blood group system is highly significantly associated with age and educational level of academic staff (OR, 0.018; 95% CI, 0.002–0.142 and OR, 0.311;95% CI, 0.1500.643). Awareness of the minimum requirements of blood donation is significantly associated with educational level and profession among academic staff (OR, 1.919;95% CI, 1.482-2.485 and OR, 1.258;95% CI, 1.059-1.494). Conclusion: This study provides a deep insight into the blood donation process among academic staff members in health colleges. The outcome of the study currentreflects an extensive knowledge and positive attitude toward blood donation. The academic staff could play a key role in increasing the awareness about blood donation among their students, which could possibly reflect on the society.
目的:本研究旨在调查和评价沙特阿拉伯南部地区卫生院校教职员工献血的知识、态度、意识和动机。方法:在沙特阿拉伯南部地区的两所大学进行了横断面描述性研究。参与者是2016年阿卜哈哈国王哈立德大学和吉赞大学卫生学院的学术人员。使用一份经过验证的、结构良好的问卷来收集数据。采用双变量logistic回归分析和比值比(OR)对研究对象献血的知识、态度、意识和动机进行评估。结果:科研人员血型知识知晓率高,与学历水平显著相关(OR = 4.161;95%置信区间[CI], 2.313 - 7.484)。恒河猴血型系统的知识与学术人员的年龄和教育水平高度显著相关(OR, 0.018;95% CI, 0.002-0.142, OR, 0.311;95% CI, 0.1500 - 643)。学术人员对献血最低要求的认识与教育水平和职业显著相关(OR, 1.919;95% CI, 1.482-2.485; OR, 1.258;95% CI, 1.059-1.494)。结论:本研究对卫生院校教职员的献血过程有深入的了解。研究结果目前反映了广泛的知识和积极的献血态度。学术人员可以在提高学生的献血意识方面发挥关键作用,这可能会对社会产生影响。
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引用次数: 0
The role of Whatsapp in scientific education at the college of applied medical sciences at Imam Abdulrahman bin Faisal University Whatsapp在伊玛目阿卜杜勒拉赫曼·本·费萨尔大学应用医学学院的科学教育中的作用
Pub Date : 1900-01-01 DOI: 10.4103/1658-743x.292038
H. Alsleem, Raghad Alsleem, M. Adam, Khalid Ibrahim, Mohammed. Saad., NadiayhH Almohiy, NoufH Abu Hadi
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引用次数: 1
Awareness of sexually transmitted diseases among male medical students in King Khalid University, Abha 哈立德国王大学男医科学生对性传播疾病的认识
Pub Date : 1900-01-01 DOI: 10.4103/1658-743x.291934
RishiKr Bharti, AwadS Samaghan, Hassan Al-Musa, Shweta M. Chaudhary, AbdulelahA H. Alqahtani, NaifD A. Alshehri, AbdulmajeedA A. Abuhabshah, AbdulrhmanJ D. Abuhabshah
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引用次数: 0
LIP repositioning surgery and its sequelae in the treatment of a gummy smile: A case report 唇部复位手术治疗粘笑的后遗症1例报告
Pub Date : 1900-01-01 DOI: 10.4103/1658-743x.292031
S. Alqahtani
Excessive gingival display, also known as “gummy smile” has several etiologies. A gummy smile is a drawback for the esthetics and social behavior of various patients. Lip repositioning surgery confers predictable results. However, lip repositioning surgery is indicated in patients with a hyperactive upper lip, while gummy smile owing to altered passive tooth eruption and vertical maxillary excess need to be addressed with crown lengthening and orthognathic surgeries, respectively. Lip repositioning surgery is an uncomplicated procedure, which reduces the muscular pull on the upper lip to achieve minimal display of dento-gingival unit while smiling. Nonetheless, few authors question the relapse of the lip position. This report describes a case showing satisfactory results with lip repositioning surgery and after 1 year follow-up shows a nonsignificant relapse in the position of the upper lip. Hence, lip repositioning surgery is a safe and predictable approach for gummy smiles with negligible relapse.
牙龈过度露出,也被称为“软糖微笑”,有几种病因。粘人的笑容对许多病人的审美和社会行为都是不利的。唇部复位手术的结果是可以预测的。然而,唇部复位手术适用于上唇过度活跃的患者,而由于被动牙萌出改变和上颌垂直过度而导致的牙龈微笑需要分别通过冠延长和正颌手术来解决。唇复位手术是一种简单的手术,它减少了上唇的肌肉牵拉,使微笑时牙牙龈单元的显示最小。尽管如此,很少有作者质疑唇位的复发。本报告描述了一个病例,显示满意的结果,重新定位手术和1年后的随访显示,在上唇的位置无明显复发。因此,唇部复位手术是一种安全、可预测的治疗粘笑的方法,复发很小。
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引用次数: 0
Reliability and validity of light-based screening techniques in detection of oral premalignant lesions 光基筛查技术在口腔癌前病变检测中的可靠性和有效性
Pub Date : 1900-01-01 DOI: 10.4103/1658-743X.291943
S. Kaleem, S. Asif, M. Z. Kota, A. Kareem, A. Othman, M. Alhusin, Ali Hudian
Objective: To assess and create awareness towards risk factors like Kath chewing and other tobacco related habits and prevalence of premalignant lesions and early detection through light based Screening tool. Methodology: -First stage comprised of an interview to get demographic and preliminary data for the study. In the second stage, the entire recruited participants underwent an oral examination, and suspected lesions were further seen by specialist dental surgeon. Exclusion is done by a specialist dentist to group them into clinical types based on clinical provisional diagnosis and are referred for histopathologic examination for further management. Third stage all suspected red and white lesions, inconspicuous lesions are screened by Acetic acid and VElscope to identify & confirm visible changes which required histopathological examination for further definitive treatment options. Result: 75% study subjects showed Aceto-whitening, 9.3% subjects showed negative result and 11.4% subjects showed false positive results and 2.8% projected as No Abnormality Detected in acetic acid test. In VElscope examination, 65.6% Showed Positive Dark areas, followed by 34.3 % False Positive results. There were no negative finding. Positive Predictive Value stands more with age old Acetic acid test (75%) when compared with advance methods like VELscope (65.6%). Conclusion: The oral cavity should be carefully examined in tobacco users. Any changes in color or texture of oral mucosa should arouse suspicion of the presence pre malignant lesions and/or oral cancer. Devices like VELscope can be used as a diagnostic aid for identification of these lesions. However, we have to realize that still the histopathological examination is the most accurate method to confirm the diagnosis.
目的:通过基于光的筛查工具,评估和提高对Kath咀嚼和其他烟草相关习惯等危险因素和癌前病变患病率的认识和早期发现。方法:-第一阶段包括访谈,以获得研究的人口统计和初步数据。在第二阶段,所有被招募的参与者都接受了口腔检查,并由专业牙科医生进一步观察可疑的病变。排除由专科牙医根据临床临时诊断将其分组为临床类型,并转介进行组织病理学检查以作进一步处理。第三阶段,所有可疑的红色和白色病变,不明显的病变,用醋酸和VElscope筛查,以识别和确认可见的变化,需要进行组织病理学检查,以进一步确定治疗方案。结果:75%的研究对象醋酸美白,9.3%的研究对象为阴性,11.4%的研究对象为假阳性,2.8%的研究对象醋酸试验无异常。VElscope检查中,65.6%为暗区阳性,34.3%为假阳性。无阴性结果。与VELscope等先进方法(65.6%)相比,老式醋酸试验(75%)的阳性预测值更高。结论:吸烟人群应仔细检查口腔。口腔黏膜颜色或质地的任何变化都应引起对恶性病变和/或口腔癌的怀疑。像VELscope这样的设备可以作为诊断工具来识别这些病变。然而,我们必须认识到,组织病理学检查仍然是最准确的诊断方法。
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引用次数: 0
A study of student awareness of radiation protection skills at jazan university 吉赞大学学生辐射防护技能意识的研究
Pub Date : 1900-01-01 DOI: 10.4103/1658-743x.292033
N. Abuhadi
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引用次数: 1
Application of topical timolol 0.5% solution for management of rosacea-related flushing and erythema: A case report 局部应用0.5%噻莫洛尔溶液治疗酒渣鼻相关潮红和红斑1例报告
Pub Date : 1900-01-01 DOI: 10.4103/1658-743x.291936
TahaniS Magliah, Esraa Turkistani
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引用次数: 2
期刊
King Khalid University Journal of Health Sciences
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